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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethotoin
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Accession:CHEBI:4888 term browser browse the term
Definition:An imidazolidine-2,4-dione that is hydantoin substituted by ethyl and phenyl at positions 3 and 5, respectively. An antiepileptic, it is less toxic than phenytoin but also less effective.
Synonyms:exact_synonym: 3-ethyl-5-phenylimidazolidine-2,4-dione
 related_synonym: 1-ethyl-2,5-dioxo-4-phenylimidazolidine;   3-Ethyl-5-phenyl-imidazolidine-2,4-dione;   3-ethyl-5-phenyl-2,4-imidazolidinedione;   3-ethyl-5-phenylhydantoin;   3-ethyl-5-phenylimidazolidin-2,4-dione;   Formula=C11H12N2O2;   InChI=1S/C11H12N2O2/c1-2-13-10(14)9(12-11(13)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,12,15);   InChIKey=SZQIFWWUIBRPBZ-UHFFFAOYSA-N;   SMILES=CCN1C(=O)NC(C1=O)c1ccccc1;   ethotoine;   ethotoinum;   etotoina
 alt_id: CHEBI:250452
 xref: CAS:86-35-1;   DrugBank:DB00754;   Drug_Central:1088;   HMDB:HMDB0014892;   KEGG:C07839;   KEGG:D00708;   LINCS:LSM-1440
 xref_mesh: MESH:C084606
 xref: PMID:1350205;   PMID:13553007;   PMID:6105055;   PMID:6145119;   Patent:US2793157;   Reaxys:188272;   Wikipedia:Ethotoin



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ethotoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO ethotoin binds to and results in increased activity of NR1I2 protein CTD PMID:15039302 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Path 1
Term Annotations click to browse term
  CHEBI ontology 20039
    role 19990
      application 19729
        pharmaceutical 19603
          drug 19603
            central nervous system drug 16581
              central nervous system depressant 16080
                anticonvulsant 15200
                  ethotoin 1
                    (R)-ethotoin 0
                    (S)-ethotoin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20039
    subatomic particle 20037
      composite particle 20037
        hadron 20037
          baryon 20037
            nucleon 20037
              atomic nucleus 20037
                atom 20037
                  main group element atom 19938
                    p-block element atom 19938
                      carbon group element atom 19861
                        carbon atom 19852
                          organic molecular entity 19852
                            organic molecule 19798
                              organic cyclic compound 19560
                                organic heterocyclic compound 18776
                                  organic heteromonocyclic compound 17161
                                    diazolidine 988
                                      imidazolidines 979
                                        imidazolidinone 613
                                          imidazolidine-2,4-dione 478
                                            ethotoin 1
                                              (R)-ethotoin 0
                                              (S)-ethotoin 0
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