Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethotoin
go back to main search page
Accession:CHEBI:4888 term browser browse the term
Definition:An imidazolidine-2,4-dione that is hydantoin substituted by ethyl and phenyl at positions 3 and 5, respectively. An antiepileptic, it is less toxic than phenytoin but also less effective.
Synonyms:exact_synonym: 3-ethyl-5-phenylimidazolidine-2,4-dione
 related_synonym: 1-ethyl-2,5-dioxo-4-phenylimidazolidine;   3-Ethyl-5-phenyl-imidazolidine-2,4-dione;   3-ethyl-5-phenyl-2,4-imidazolidinedione;   3-ethyl-5-phenylhydantoin;   3-ethyl-5-phenylimidazolidin-2,4-dione;   Formula=C11H12N2O2;   InChI=1S/C11H12N2O2/c1-2-13-10(14)9(12-11(13)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H,12,15);   InChIKey=SZQIFWWUIBRPBZ-UHFFFAOYSA-N;   SMILES=CCN1C(=O)NC(C1=O)c1ccccc1;   ethotoine;   ethotoinum;   etotoina
 alt_id: CHEBI:250452
 xref: CAS:86-35-1;   DrugBank:DB00754;   Drug_Central:1088;   HMDB:HMDB0014892;   KEGG:C07839;   KEGG:D00708;   LINCS:LSM-1440
 xref_mesh: MESH:C084606
 xref: PMID:1350205;   PMID:13553007;   PMID:6105055;   PMID:6145119;   Patent:US2793157;   Reaxys:188272;   Wikipedia:Ethotoin


show annotations for term's descendants           Sort by:
 
ethotoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO ethotoin binds to and results in increased activity of NR1I2 protein CTD PMID:15039302 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      application 19494
        pharmaceutical 19364
          drug 19364
            central nervous system drug 16506
              central nervous system depressant 16038
                anticonvulsant 15171
                  ethotoin 1
                    (R)-ethotoin 0
                    (S)-ethotoin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                organic heterocyclic compound 18511
                                  organic heteromonocyclic compound 16621
                                    diazolidine 588
                                      imidazolidines 578
                                        imidazolidinone 479
                                          imidazolidine-2,4-dione 458
                                            ethotoin 1
                                              (R)-ethotoin 0
                                              (S)-ethotoin 0
paths to the root