nicotinic antagonist - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	nicotinic antagonist	go back to main search page
Accession:	CHEBI:48878	browse the term
Definition:	An antagonist at the nicotinic cholinergic receptor.
Synonyms:	related_synonym:	agente antinicotinico; agentes antinicotinicos; agents antinicotiniques; antinicotinicos; nicotinic acetylcholine receptor antagonist; nicotinic acetylcholine receptor antagonists; nicotinic antagonists; nicotinic cholinergic antagonist; nicotinic cholinergic antagonists
	xref:	Wikipedia:Nicotinic_antagonist

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Rat (210) Mouse (212) Human (212) Chinchilla (0) Bonobo (0) Dog (2) Squirrel (0) Pig (1) Green Monkey (0) Naked Mole-rat (0) All
Genes (210)

(R,R)-tramadol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

increases expression

Tramadol results in increased expression of ADRA1A protein

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression

Vitamin E inhibits the reaction [Tramadol results in increased expression of ALPL protein]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

BCL2 associated X, apoptosis regulator

increases expression

Tramadol results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

decreases activity

Tramadol results in decreased activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

caspase 3

affects activity
multiple interactions
increases expression
decreases activity

Tramadol affects the activity of CASP3 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
Tramadol results in decreased activity of CASP3 protein

PMID:27317026 PMID:28499616 PMID:31618080

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

decreases expression
multiple interactions

Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]

PMID:25550769 PMID:31618080

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

creatine kinase B

decreases expression
multiple interactions

Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

PMID:27317026 PMID:33645892

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

creatine kinase, M-type

multiple interactions

Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity

Tramadol results in decreased activity of CYP17A1 protein

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
affects methylation
multiple interactions
decreases methylation
affects response to substance
decreases response to substance
increases response to substance
increases metabolic processing

CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol

PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More...

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

desmin

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of DES protein]

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

dopamine receptor D2

increases expression

Tramadol results in increased expression of DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

increases expression

Tramadol results in increased expression of DRD3 protein

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

gap junction protein, alpha 1

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein]

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glutamic-oxaloacetic transaminase 1

multiple interactions
increases expression

Vitamin E inhibits the reaction [Tramadol results in increased expression of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

increases activity
multiple interactions
increases expression

Tramadol results in increased activity of GPT protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]

PMID:28689766 PMID:31618080

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

5-hydroxytryptamine receptor 2A

increases activity
increases expression
multiple interactions

Tramadol results in increased activity of HTR2A protein
Tramadol results in increased expression of HTR2A mRNA
Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

interferon gamma

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

lactate dehydrogenase A

decreases expression

Tramadol results in decreased expression of LDHA mRNA

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

NADH:ubiquinone oxidoreductase core subunit S1

decreases expression

Tramadol results in decreased expression of NDUFS1 mRNA

NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893

G

opioid receptor, delta 1

affects binding
multiple interactions

Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

affects binding
multiple interactions

Tramadol binds to OPRK1 protein
[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

affects binding
multiple interactions

Tramadol binds to OPRM1 protein
[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

pyruvate dehydrogenase kinase 3

increases expression

Tramadol results in increased expression of PDK3 mRNA

NCBI chr X:58,486,699...58,553,533
Ensembl chr X:58,486,554...58,553,557

G

prodynorphin

decreases expression

Tramadol results in decreased expression of PDYN mRNA

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

solute carrier family 2 member 4

multiple interactions

Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 47 member 1

multiple interactions

Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

superoxide dismutase 1

decreases expression
multiple interactions

Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]

PMID:25550769 PMID:31618080

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
decreases expression

Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

secreted phosphoprotein 1

multiple interactions
increases expression

Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

tumor necrosis factor

multiple interactions
increases expression

[Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein]

PMID:17377112 PMID:31618080 PMID:33645892

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

troponin I3, cardiac type

multiple interactions
increases expression

Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

G

vimentin

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

3beta-(2-diethylaminoethoxy)androst-5-en-17-one hydrochloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glypican 1

decreases degradation

3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one results in decreased degradation of GPC1 protein

NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047

atracurium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

Atracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]

NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

cholinergic receptor nicotinic beta 4 subunit

multiple interactions

Atracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027

G

hexosaminidase subunit beta

increases secretion

Atracurium results in increased secretion of HEXB protein

NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223

cisatracurium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cadherin 1

multiple interactions
increases expression

CXCR4 protein inhibits the reaction [cisatracurium results in increased expression of CDH1 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in increased expression of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

decreases expression
multiple interactions

cisatracurium results in decreased expression of CDH2 protein
CXCR4 protein inhibits the reaction [cisatracurium results in decreased expression of CDH2 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of CDH2 protein]

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

cisatracurium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]

NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

cholinergic receptor nicotinic beta 4 subunit

multiple interactions

cisatracurium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027

G

C-X-C motif chemokine receptor 4

decreases expression
decreases expression
multiple interactions

cisatracurium results in decreased expression of CXCR4 mRNA; cisatracurium results in decreased expression of CXCR4 protein
cisatracurium decreases expression of CXCR4 mRNA and protein in colonic epithelium
CXCR4 protein inhibits the reaction [cisatracurium results in decreased expression of CDH2 protein]; CXCR4 protein inhibits the reaction [cisatracurium results in decreased expression of VIM protein]; CXCR4 protein inhibits the reaction [cisatracurium results in increased expression of CDH1 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of CXCR4 protein]

CTD
RGD

PMID:33617803 PMID:33617803

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

transforming growth factor, beta 1

multiple interactions
decreases expression

TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of CDH2 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of CXCR4 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of TGFBR1 protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of VIM protein]; TGFB1 protein inhibits the reaction [cisatracurium results in increased expression of CDH1 protein]
cisatracurium results in decreased expression of TGFB1 protein

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 1

decreases expression
multiple interactions

cisatracurium results in decreased expression of TGFBR1 protein
TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of TGFBR1 protein]

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

vimentin

decreases expression
multiple interactions

cisatracurium results in decreased expression of VIM protein
CXCR4 protein inhibits the reaction [cisatracurium results in decreased expression of VIM protein]; TGFB1 protein inhibits the reaction [cisatracurium results in decreased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

dihydro-beta-erythroidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

atonal bHLH transcription factor 1

multiple interactions

Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of ATOH1 mRNA]

NCBI chr 4:93,912,068...93,914,163
Ensembl chr 4:93,912,068...93,914,154

G

cyclin D1

multiple interactions

Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CCND1 mRNA]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase 4

multiple interactions

Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cholinergic receptor nicotinic alpha 2 subunit

multiple interactions

dihydro-beta-erythroidine affects binding to Chrna2 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrna2 protein] in rat retina

RGD

NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Dihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
dihydro-beta-erythroidine affects binding [Epibatidine binds to Chrna3 protein]

CTD
RGD

PMID:9687574 PMID:16129735 PMID:15016836

RGD:2303195, RGD:2303194

NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions
affects binding

Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
dihydro-beta-erythroidine affects binding to Chrna4 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrna4 protein] in rat retina
dihydro-beta-erythroidine affects binding to Chrna4 protein; dihydro-beta-erythroidine competes with [Epibatidine binds to Chrna4 protein]
[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; Dihydro-beta-Erythroidine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of CHRNA4 mRNA]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
[CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-Erythroidine

CTD
RGD

PMID:9687574 PMID:10945867 PMID:11600638 PMID:12604691 PMID:14645658 More...

RGD:2303195, RGD:2303194

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

increases activity
multiple interactions
affects response to substance

Dihydro-beta-Erythroidine results in increased activity of CHRNA7 protein mutant form
Dihydro-beta-Erythroidine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]
CHRNA7 protein mutant form affects the susceptibility to Dihydro-beta-Erythroidine
Dihydro-beta-Erythroidine binds to and results in decreased activity of CHRNA7 protein

PMID:10082212 PMID:19448648

NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
dihydro-beta-erythroidine affects binding to Chrnb2 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrnb2 protein] in rat retina
dihydro-beta-erythroidine affects binding to Chrnb2 protein; dihydro-beta-erythroidine competes with [Epibatidine binds to Chrnb2 protein]
Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; Dihydro-beta-Erythroidine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

CTD
RGD

PMID:10945867 PMID:11600638 PMID:12604691 PMID:14645658 PMID:16569710 More...

RGD:2303195, RGD:2303194

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

cholinergic receptor nicotinic beta 3 subunit

multiple interactions

dihydro-beta-erythroidine affects binding to Chrnb3 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrnb3 protein] in rat retina

RGD

NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360

G

cholinergic receptor nicotinic beta 4 subunit

affects binding
multiple interactions

[CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-Erythroidine
Dihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]

NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027

G

C-X-C motif chemokine receptor 4

multiple interactions

[Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein]

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

DNA methyltransferase 1

multiple interactions

Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in decreased expression of DNMT1 mRNA]

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

glutamate decarboxylase 1

multiple interactions

Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of GAD1 mRNA]

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

solute carrier family 6 member 3

multiple interactions

Dihydro-beta-Erythroidine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein]

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

TNF receptor superfamily member 11B

multiple interactions

Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of TNFRSF11B mRNA]

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF superfamily member 11

multiple interactions

Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of TNFSF11 mRNA]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

dizocilpine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

dopamine receptor D2

affects binding

Dizocilpine binds to Drd2 protein

RGD

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

glutamate ionotropic receptor AMPA type subunit 1

multiple interactions

Dizocilpine inhibits the reaction [Cocaine increases expression of Gria1 protein in the nucleus accumbens]

RGD

NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283

G

sirtuin 1

increases expression

dizocilpine cotreated with cocaine increases expression of Sirt1 protein in nucleus accumbens

RGD

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

dizocilpine maleate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine A3 receptor

multiple interactions

[N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Dizocilpine Maleate

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

G

adenosylhomocysteinase-like 2

increases expression

Dizocilpine Maleate results in increased expression of AHCYL2 protein

NCBI chr 4:58,381,290...58,531,061
Ensembl chr 4:58,381,218...58,531,060

G

aryl hydrocarbon receptor

multiple interactions

Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists affects the localization of AIFM1 protein]

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

aldolase, fructose-bisphosphate C

increases expression

Dizocilpine Maleate results in increased expression of ALDOC protein

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

amyloid beta precursor protein

multiple interactions

Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

activity-regulated cytoskeleton-associated protein

multiple interactions

Dizocilpine Maleate inhibits the reaction [phosphinothricin results in increased expression of ARC mRNA]

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Dizocilpine Maleate results in increased expression of BAX protein
Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of BAX protein]; Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of BAX protein]

PMID:19201465 PMID:19759125 PMID:25937004 PMID:28916251

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Dizocilpine Maleate results in decreased expression of BCL2 protein
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]
Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in decreased expression of BCL2 protein]

PMID:10859492 PMID:19879923 PMID:29151189

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2L1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

brain-derived neurotrophic factor

decreases expression
affects expression
multiple interactions

Dizocilpine Maleate results in decreased expression of BDNF mRNA
Dizocilpine Maleate affects the expression of BDNF mRNA
Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of and results in increased localization of BDNF mRNA]; Pentobarbital inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]; Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]

PMID:8247360 PMID:8405262 PMID:15282290

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

calcium/calmodulin-dependent protein kinase II alpha

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

calcium/calmodulin-dependent protein kinase IV

multiple interactions

Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein]

NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487

G

caspase 3

multiple interactions
increases expression
increases activity

Dizocilpine Maleate inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased activity of and results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]
Dizocilpine Maleate results in increased expression of CASP3 protein modified form
Dizocilpine Maleate results in increased activity of CASP3 protein

PMID:19759125 PMID:21873648 PMID:22824136 PMID:25937004 PMID:28916251 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases activity

Dizocilpine Maleate results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

[bastadin 12 co-treated with Ryanodine co-treated with Dizocilpine Maleate] inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein]; Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of CAT protein]

PMID:12885441 PMID:27718046

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cholecystokinin

multiple interactions
decreases expression

Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein]
Dizocilpine Maleate results in decreased expression of CCK mRNA; Dizocilpine Maleate results in decreased expression of CCK protein

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

choline O-acetyltransferase

multiple interactions

Dizocilpine Maleate inhibits the reaction [Quinolinic Acid results in decreased activity of CHAT protein]

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

cannabinoid receptor 1

affects response to substance

CNR1 protein affects the susceptibility to Dizocilpine Maleate

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

collagen type I alpha 1 chain

multiple interactions
increases expression

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of COL1A1 mRNA]
Dizocilpine Maleate results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of COL3A1 mRNA]

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

cAMP responsive element binding protein 1

increases phosphorylation
multiple interactions
decreases phosphorylation

Dizocilpine Maleate results in increased phosphorylation of CREB1 protein
Dizocilpine Maleate inhibits the reaction [Sodium Glutamate results in increased expression of CREB1 mRNA]
Dizocilpine Maleate inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein]; Dizocilpine Maleate inhibits the reaction [Dopamine results in increased phosphorylation of CREB1 protein]; Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]]
Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of CREB1 mRNA]
Dizocilpine Maleate results in decreased phosphorylation of CREB1 protein

PMID:14622123 PMID:15877933 PMID:17434604 PMID:17973980 PMID:31981724

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

catenin beta 1

decreases expression
multiple interactions

Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA
Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]; Olanzapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 2

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased activity of CXCL2 protein]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 46, subfamily a, polypeptide 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Sodium Glutamate results in increased expression of CYP46A1 mRNA]; Dizocilpine Maleate inhibits the reaction [Sodium Glutamate results in increased expression of CYP46A1 protein]

NCBI chr 6:127,247,543...127,274,765
Ensembl chr 6:127,243,315...127,274,760

G

discs large MAGUK scaffold protein 1

increases expression

Dizocilpine Maleate results in increased expression of DLG1 mRNA

NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689

G

discs large MAGUK scaffold protein 4

increases expression

Dizocilpine Maleate results in increased expression of DLG4 mRNA

NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153

G

dynamin 1-like

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of DNM1L protein]

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

dopamine receptor D1

multiple interactions

[[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Dizocilpine Maleate] co-treated with [1-hydroxy-3-amino-2-pyrrolidone results in increased activity of DRD1 protein]] results in increased susceptibility to Pilocarpine; Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD1 mRNA]

PMID:7906944 PMID:17434604

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

multiple interactions

Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD2 mRNA]

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

dual specificity phosphatase 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Methamphetamine results in increased expression of DUSP1 mRNA]

NCBI chr10:16,680,478...16,683,275

G

dual specificity phosphatase 6

multiple interactions

Dizocilpine Maleate inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA]

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

early growth response 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Zinc results in increased expression of EGR1 protein]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

multiple interactions

Dizocilpine Maleate inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of ERN1 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

fatty acid amide hydrolase

decreases activity

Dizocilpine Maleate results in decreased activity of FAAH protein

NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677

G

fibroblast growth factor 2

increases expression

Dizocilpine Maleate results in increased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression
decreases expression

[Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Haloperidol results in increased expression of FOS protein]
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Dextroamphetamine results in increased expression of FOS mRNA]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
Dizocilpine Maleate results in increased expression of FOS mRNA
Dizocilpine Maleate results in decreased expression of FOS mRNA; Dizocilpine Maleate results in decreased expression of FOS protein

PMID:7984056 PMID:8404677 PMID:11421588 PMID:12401322 PMID:12807422 More...

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases response to substance

FOSB protein modified form results in increased susceptibility to Dizocilpine Maleate

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

glutamate decarboxylase 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Oxygen deficiency results in decreased expression of GAD1 protein]

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

galanin and GMAP prepropeptide

multiple interactions

Dizocilpine Maleate inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of GAL mRNA]

NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959

G

growth associated protein 43

multiple interactions

Dizocilpine Maleate inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA]

NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

Dizocilpine Maleate results in increased expression of GAPDH protein

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glial fibrillary acidic protein

multiple interactions

Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein]

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

glutamate ionotropic receptor AMPA type subunit 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIA1 protein]

NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283

G

glutamate ionotropic receptor NMDA type subunit 1

decreases activity
multiple interactions
increases expression
affects binding

Dizocilpine Maleate results in decreased activity of GRIN1 protein
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN1 protein]; Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in increased expression of GRIN1 protein]; Dizocilpine Maleate promotes the reaction [GRIN1 protein binds to SRC protein]
[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Dizocilpine Maleate; [GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to Dizocilpine Maleate; Dizocilpine Maleate inhibits the reaction [[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists]
Dizocilpine Maleate results in increased expression of GRIN1 mRNA
Dizocilpine Maleate binds to GRIN1 protein

PMID:11249956 PMID:11801363 PMID:19224577 PMID:19788891 PMID:20406136 More...

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2A

multiple interactions
increases phosphorylation

Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of GRIN2A mRNA]
Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in increased expression of GRIN2A protein]
[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Dizocilpine Maleate; Dizocilpine Maleate inhibits the reaction [[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists]
Dizocilpine Maleate results in increased phosphorylation of GRIN2A protein

PMID:11249956 PMID:17434604 PMID:19224577 PMID:20406136

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions
decreases expression

Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]
[GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to Dizocilpine Maleate
Dizocilpine Maleate results in decreased expression of GRIN2B mRNA

PMID:11169168 PMID:11801363 PMID:19224577 PMID:28916251

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

glutamate ionotropic receptor NMDA type subunit 2C

decreases expression

Dizocilpine Maleate results in decreased expression of GRIN2C mRNA

NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427

G

glycogen synthase kinase 3 beta

multiple interactions
increases phosphorylation
increases expression

3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein; Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Famotidine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]; Olanzapine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]
Dizocilpine Maleate results in increased phosphorylation of GSK3B protein

PMID:15877933 PMID:31563592

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein]

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

interleukin 1 beta

multiple interactions

Dizocilpine Maleate inhibits the reaction [Ibotenic Acid results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

Dizocilpine Maleate inhibits the reaction [Ibotenic Acid results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibin subunit beta A

multiple interactions

Dizocilpine Maleate inhibits the reaction [Ibotenic Acid results in increased expression of INHBA protein]

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Dizocilpine Maleate inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of JUNB mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]

PMID:7984056 PMID:9890435

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

monoamine oxidase A

multiple interactions

Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased activity of MAOA protein]

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

[Dizocilpine Maleate co-treated with 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline] inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
Dizocilpine Maleate results in decreased phosphorylation of MAPK1 protein
Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK1 protein]

PMID:11553284 PMID:11923223 PMID:12657697 PMID:15086530 PMID:15385614 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions

Dizocilpine Maleate results in decreased phosphorylation of MAPK3 protein
[Dizocilpine Maleate co-treated with 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline] inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK3 protein]
Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK3 protein]

PMID:11553284 PMID:11923223 PMID:12657697 PMID:15086530 PMID:15385614 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

multiple interactions

Dizocilpine Maleate inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPT protein]
Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased expression of and affects the phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased cleavage of MAPT protein]

PMID:21976409 PMID:30822420

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

mitofusin 2

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of MFN2 protein]

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

matrix metallopeptidase 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in decreased expression of MMP1 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein]

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 9

multiple interactions

Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in decreased expression of MMP9 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

neurofilament light chain

multiple interactions

Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Dizocilpine Maleate inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA]

PMID:21863293 PMID:31969611

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

neurofilament medium chain

multiple interactions

Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein]

NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755

G

NFKB inhibitor alpha

multiple interactions

Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NME/NM23 nucleoside diphosphate kinase 1

increases expression

Dizocilpine Maleate results in increased expression of NME1 protein

NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408

G

nitric oxide synthase 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of NOS1 protein]

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

multiple interactions

Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

neuropeptide S

decreases activity
multiple interactions

NPS protein results in decreased activity of Dizocilpine Maleate
3-oxo-1,1-diphenyltetrahydrooxazolo(3,4-a)pyrazine-7-carboxylic acid 4-fluorobenzylamide inhibits the reaction [NPS protein results in decreased activity of Dizocilpine Maleate]

NCBI chr 1:190,077,040...190,080,821
Ensembl chr 1:190,077,040...190,080,821

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

increases expression

Dizocilpine Maleate results in increased expression of NSF protein

NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386

G

occludin

multiple interactions

Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of OCLN protein]

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

opioid receptor, mu 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

poly (ADP-ribose) polymerase 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phosphodiesterase 2A

multiple interactions

Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of PDE2A mRNA]

NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434

G

phosphodiesterase 5A

multiple interactions

Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of PDE5A mRNA]

NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701

G

proenkephalin

multiple interactions

Dizocilpine Maleate inhibits the reaction [Amphetamine results in increased expression of PENK mRNA]

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

G

proopiomelanocortin

multiple interactions

Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased secretion of POMC protein]

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

protein kinase C, alpha

multiple interactions

Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, gamma

increases expression
multiple interactions

Dizocilpine Maleate results in increased expression of PRKCG mRNA
Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]

PMID:11169168 PMID:18652891

NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384

G

prolactin

decreases expression

Dizocilpine Maleate results in decreased expression of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

proline dehydrogenase

affects response to substance

PRODH protein affects the susceptibility to Dizocilpine Maleate

NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Dizocilpine Maleate inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

pleiotrophin

multiple interactions

Dizocilpine Maleate promotes the reaction [Amphetamine results in increased expression of PTN mRNA]

NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456

G

Rac family small GTPase 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [bisphenol A results in increased expression of RAC1 protein]; Dizocilpine Maleate inhibits the reaction [Estradiol results in increased expression of RAC1 protein]

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

retinoic acid receptor, alpha

multiple interactions

Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]]

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

ras homolog family member A

multiple interactions

Dizocilpine Maleate inhibits the reaction [bisphenol A results in decreased expression of RHOA protein]; Dizocilpine Maleate inhibits the reaction [Estradiol results in decreased expression of RHOA protein]

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

sirtuin 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

superoxide dismutase 2

multiple interactions

Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of SOD2 protein]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions
increases activity
increases expression

Dizocilpine Maleate promotes the reaction [GRIN1 protein binds to SRC protein]; Dizocilpine Maleate results in increased phosphorylation of and results in increased activity of SRC protein
Dizocilpine Maleate results in increased activity of SRC protein
Dizocilpine Maleate results in increased expression of SRC mRNA; Dizocilpine Maleate results in increased expression of SRC protein

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

somatostatin

decreases expression
multiple interactions

Dizocilpine Maleate results in decreased expression of SST mRNA; Dizocilpine Maleate results in decreased expression of SST protein
Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein]

NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173

G

tachykinin, precursor 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of TAC1 protein modified form]

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

transforming growth factor alpha

multiple interactions

Dizocilpine Maleate inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFA]

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

TIMP metallopeptidase inhibitor 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 protein]

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tight junction protein 1

multiple interactions

Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

triosephosphate isomerase 1

increases expression

Dizocilpine Maleate results in increased expression of TPI1 protein

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

vimentin

multiple interactions

Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

xanthine dehydrogenase

multiple interactions

Dizocilpine Maleate inhibits the reaction [ammonium acetate affects the activity of XDH protein]

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

kynurenic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

Kynurenic Acid inhibits the reaction [ABCB11 protein results in increased uptake of Taurocholic Acid]

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily C member 4

multiple interactions

Kynurenic Acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily G member 2

multiple interactions

Kynurenic Acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

aryl hydrocarbon receptor

multiple interactions
increases activity

AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; Kynurenic Acid binds to and results in increased activity of AHR protein
Kynurenic Acid analog results in increased activity of AHR protein; Kynurenic Acid results in increased activity of AHR protein

PMID:20106948 PMID:27020609 PMID:28336214

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

collagen type II alpha 1 chain

multiple interactions

[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Kynurenic Acid

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression
increases activity

[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]
Kynurenic Acid results in increased expression of CYP1A1 mRNA
Kynurenic Acid results in increased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

fibroblast growth factor 1

decreases secretion

Kynurenic Acid results in decreased secretion of FGF1 protein

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

G protein-coupled receptor 35

multiple interactions

Kynurenic Acid binds to and results in increased activity of GPR35 protein

NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:93,527,127...93,539,299

G

interleukin 1 beta

multiple interactions

[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; IL1B protein promotes the reaction [Kynurenic Acid results in increased expression of IL6 mRNA]
Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL1B protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]

PMID:20106948 PMID:35123988

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
increases expression

AHR protein affects the reaction [[Kynurenic Acid co-treated with IL1B protein] results in increased expression of IL6 mRNA]; IL1B protein promotes the reaction [Kynurenic Acid results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 2

multiple interactions

Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased chemical synthesis of Nitric Oxide]; Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

kynurenine 3-monooxygenase

multiple interactions

[Ro 61-8048 results in decreased activity of KMO protein] which results in increased abundance of Kynurenic Acid

NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881

G

myeloperoxidase

multiple interactions

Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

NFKB inhibitor alpha

multiple interactions

Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

occludin

multiple interactions

Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of OCLN protein]

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]; Kynurenic Acid promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 2 member 3

multiple interactions

Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased expression of SLC2A3 protein]

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

G

tight junction protein 1

multiple interactions

Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of TJP1 protein]

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

tumor necrosis factor

multiple interactions

Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; methyl 5-((tert-butylcarbamothioylhydrazinylidene)methyl)-1-(2,4-difluorophenyl)pyrazole-4-carboxylate inhibits the reaction [Kynurenic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

pancuronium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

Pancuronium results in decreased activity of ACHE protein

PMID:24157926 PMID:25522658

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

cholinergic receptor, muscarinic 1

multiple interactions

Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]

NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356

G

cholinergic receptor, muscarinic 2

multiple interactions

Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]

NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

multiple interactions

Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]

NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278

G

cholinergic receptor, muscarinic 4

multiple interactions

Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]

NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159

G

cholinergic receptor, muscarinic 5

multiple interactions

Pancuronium inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]

NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

PMID:14645658 PMID:16931985

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

Pancuronium inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]

NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

PMID:14645658 PMID:16931985

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

cholinergic receptor nicotinic beta 4 subunit

multiple interactions

Pancuronium inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027

tramadol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

increases expression

Tramadol results in increased expression of ADRA1A protein

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression

Vitamin E inhibits the reaction [Tramadol results in increased expression of ALPL protein]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

BCL2 associated X, apoptosis regulator

increases expression

Tramadol results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

decreases activity

Tramadol results in decreased activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

caspase 3

affects activity
increases expression
multiple interactions
decreases activity

Tramadol affects the activity of CASP3 protein
Tramadol results in increased expression of CASP3 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
Tramadol results in decreased activity of CASP3 protein

PMID:27317026 PMID:28499616 PMID:31618080

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

decreases expression
multiple interactions

Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]

PMID:25550769 PMID:31618080

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

creatine kinase B

decreases expression
multiple interactions

Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

PMID:27317026 PMID:33645892

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

creatine kinase, M-type

multiple interactions

Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

cAMP responsive element binding protein 1

increases phosphorylation

tramadol increases phosphorylation of Creb1 protein in Prefrontal Cortex and nucleus accumbens

RGD

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity

Tramadol results in decreased activity of CYP17A1 protein

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases response to substance
affects methylation
increases metabolic processing
decreases methylation
multiple interactions
affects response to substance
decreases response to substance
affects metabolic processing

CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 protein affects the methylation of Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol

PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More...

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

desmin

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of DES protein]

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

dopamine receptor D2

increases expression

Tramadol results in increased expression of DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

increases expression

Tramadol results in increased expression of DRD3 protein

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

Tramadol increases expression of Fosb protein in Prefrontal Cortex and nucleus accumbens

RGD

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

gap junction protein, alpha 1

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein]

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glutamic-oxaloacetic transaminase 1

increases expression
multiple interactions

Tramadol results in increased expression of GOT1 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

increases activity
multiple interactions
increases expression

Tramadol results in increased activity of GPT protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]

PMID:28689766 PMID:31618080

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

5-hydroxytryptamine receptor 2A

multiple interactions
increases activity
increases expression

Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]
Tramadol results in increased expression of HTR2A mRNA

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

interferon gamma

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

lactate dehydrogenase A

decreases expression

Tramadol results in decreased expression of LDHA mRNA

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

NADH:ubiquinone oxidoreductase core subunit S1

decreases expression

Tramadol results in decreased expression of NDUFS1 mRNA

NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893

G

opioid receptor, delta 1

affects binding
multiple interactions

Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

multiple interactions
affects binding

[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

multiple interactions
affects binding

[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

pyruvate dehydrogenase kinase 3

increases expression

Tramadol results in increased expression of PDK3 mRNA

NCBI chr X:58,486,699...58,553,533
Ensembl chr X:58,486,554...58,553,557

G

prodynorphin

decreases expression

Tramadol results in decreased expression of PDYN mRNA

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

solute carrier family 2 member 4

multiple interactions

Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 47 member 1

multiple interactions

Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

superoxide dismutase 1

decreases expression
multiple interactions

Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]

PMID:25550769 PMID:31618080

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
decreases expression

Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

secreted phosphoprotein 1

multiple interactions
increases expression

Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

tumor necrosis factor

multiple interactions
increases expression

[Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein]

PMID:17377112 PMID:31618080 PMID:33645892

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

troponin I3, cardiac type

increases expression
multiple interactions

Tramadol results in increased expression of TNNI3 protein
Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

G

vimentin

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

trimethaphan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

sialophorin

decreases response to substance

SPN protein results in decreased susceptibility to Trimethaphan

NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628

tubocurarine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions

Tubocurarine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [haloxon results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

amyloid beta precursor protein

multiple interactions

Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form]; Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

BCL2, apoptosis regulator

multiple interactions

Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone gamma-carboxyglutamate protein

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased expression of BGLAP]

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

complement C7

multiple interactions
decreases expression

Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]
Tubocurarine results in decreased expression of C7 mRNA

NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535

G

cyclin-dependent kinase 4

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cholinergic receptor nicotinic alpha 1 subunit

multiple interactions

Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein]

NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840

G

cholinergic receptor nicotinic alpha 2 subunit

multiple interactions

Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]

NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]

PMID:7808438 PMID:9687574 PMID:16931985 PMID:34628512

NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNA4 protein]

PMID:7756618 PMID:11711029 PMID:14645658 PMID:16931985

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

Tubocurarine binds to and results in decreased activity of CHRNA7 protein; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; Tubocurarine inhibits the reaction [Bungarotoxins binds to CHRNA7 protein]

PMID:10082212 PMID:10216184 PMID:16931985

NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Tubocurarine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [Ethinyl Estradiol promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]]; Tubocurarine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA2 protein]]; Tubocurarine inhibits the reaction [Acetylcholine binds to and results in increased activity of [CHRNB2 protein binds to CHRNA3 protein]]
Tubocurarine inhibits the reaction [Nicotine results in increased expression of CHRNB2 protein]

PMID:7756618 PMID:7808438 PMID:11711029 PMID:14645658 PMID:16931985

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

cholinergic receptor nicotinic beta 4 subunit

multiple interactions

Tubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]
Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]

PMID:7808438 PMID:9687574 PMID:16931985 PMID:34628512

NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027

G

contactin 1

increases expression
decreases expression
multiple interactions

Tubocurarine results in increased expression of CNTN1 mRNA
Tubocurarine results in decreased expression of CNTN1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]

PMID:12588870 PMID:16949557

NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541

G

colony stimulating factor 2

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased secretion of CSF2 protein]

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

dihydrofolate reductase

multiple interactions
decreases expression

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]
Tubocurarine results in decreased expression of DHFR mRNA

NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713

G

EMAP like 4

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of EML4 mRNA]

NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879

G

Fas cell surface death receptor

multiple interactions

Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fasciculation and elongation protein zeta 1

multiple interactions
decreases expression

Tubocurarine promotes the reaction [Nicotine results in decreased expression of FEZ1 mRNA]
Tubocurarine results in decreased expression of FEZ1 mRNA

NCBI chr 8:36,544,462...36,589,684
Ensembl chr 8:36,544,535...36,589,683

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased expression of FOS]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

golgin A4

decreases expression
multiple interactions

Tubocurarine results in decreased expression of GOLGA4 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of GOLGA4 mRNA]

NCBI chr 8:118,208,200...118,285,003

G

interleukin 1 beta

multiple interactions

Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased expression of CXCL8 mRNA]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [IL1B protein results in increased secretion of CXCL8 protein]]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

potassium calcium-activated channel subfamily N member 1

decreases activity

Tubocurarine results in decreased activity of KCNN1 protein

NCBI chr16:18,574,858...18,598,585
Ensembl chr16:18,585,992...18,597,482

G

potassium calcium-activated channel subfamily N member 2

decreases activity

Tubocurarine results in decreased activity of KCNN2 protein

PMID:10696100 PMID:10991935

NCBI chr18:37,817,966...38,258,347
Ensembl chr18:37,817,957...38,258,347

G

lysine methyltransferase 2C

multiple interactions
decreases expression

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]
Tubocurarine results in decreased expression of KMT2C mRNA

NCBI chr 4:9,620,638...9,834,787
Ensembl chr 4:9,609,627...9,833,539

G

lipopolysaccharide-induced TNF factor

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of LITAF mRNA]

NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763

G

mitogen activated protein kinase 1

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 1

multiple interactions

Tubocurarine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP1 protein]]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of MMP1 protein]

PMID:17151781 PMID:18986645

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

ninein

multiple interactions
decreases expression

Tubocurarine inhibits the reaction [Nicotine results in increased expression of NIN mRNA]
Tubocurarine results in decreased expression of NIN mRNA

NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639

G

plasminogen activator, urokinase

multiple interactions

Tubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein]

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

POU class 5 homeobox 1

decreases expression
multiple interactions

Tubocurarine results in decreased expression of POU5F1 mRNA
Tubocurarine inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]

PMID:15612475 PMID:15749260

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

parkin RBR E3 ubiquitin protein ligase

decreases expression

Tubocurarine results in decreased expression of PRKN mRNA

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

prothymosin alpha

multiple interactions

Tubocurarine inhibits the reaction [PTMA protein results in decreased expression of BCL2]; Tubocurarine inhibits the reaction [PTMA protein results in increased expression of FAS]

NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333

G

protein tyrosine phosphatase, receptor type, A

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of PTPRA mRNA]

NCBI chr 3:117,650,146...117,759,744
Ensembl chr 3:117,650,183...117,759,728

G

RB binding protein 6, ubiquitin ligase

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of RBBP6 mRNA]

NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678

G

surfactant protein A1

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPA1 mRNA]

NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685

G

surfactant protein C

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased expression of SFTPC mRNA]

NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777

G

SOS Ras/Rac guanine nucleotide exchange factor 1

multiple interactions
decreases expression

Tubocurarine inhibits the reaction [Nicotine results in increased expression of SOS1 mRNA]
Tubocurarine results in decreased expression of SOS1 mRNA

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

secreted phosphoprotein 1

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased expression of SPP1 protein]

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

stress-induced phosphoprotein 1

multiple interactions
decreases expression

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of STIP1 mRNA]
Tubocurarine results in decreased expression of STIP1 mRNA

NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476

G

ubiquitin-conjugating enzyme E2C

multiple interactions
decreases expression

Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE2C mRNA]
Tubocurarine results in decreased expression of UBE2C mRNA

NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339

G

ubiquitin protein ligase E3A

increases expression
multiple interactions

Tubocurarine results in increased expression of UBE3A mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of UBE3A mRNA]

NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250

G

xanthine dehydrogenase

multiple interactions

Tubocurarine inhibits the reaction [Isoflurophate results in increased expression of XDH protein alternative form]

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

G

zinc finger protein 42

multiple interactions

Tubocurarine inhibits the reaction [Nicotine results in increased expression of ZFP42 mRNA]

NCBI chr16:48,836,463...48,845,443
Ensembl chr16:48,836,648...48,845,401

G

zinc finger RNA binding protein

decreases expression
multiple interactions

Tubocurarine results in decreased expression of ZFR mRNA
Tubocurarine inhibits the reaction [Nicotine results in decreased expression of ZFR mRNA]

NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322

vecuronium bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCA1 protein]

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily G member 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of ABCG1 protein]

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

cholinergic receptor, muscarinic 1

multiple interactions

Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]

NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356

G

cholinergic receptor, muscarinic 2

multiple interactions

Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM2 protein]

NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103

G

cholinergic receptor, muscarinic 3

multiple interactions

Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM3 protein]

NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278

G

cholinergic receptor, muscarinic 4

multiple interactions

Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM4 protein]

NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159

G

cholinergic receptor, muscarinic 5

multiple interactions

Vecuronium Bromide inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]

NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

PMID:14645658 PMID:16931985

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]

NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]

PMID:14645658 PMID:16931985

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

cholinergic receptor nicotinic beta 4 subunit

multiple interactions

Vecuronium Bromide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]

NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP11A1 protein]

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of CYP19A1 protein]

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

early growth response 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of EGR1 protein]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

ETS transcription factor ELK1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of ELK1 protein]

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

histone deacetylase 4

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in increased expression of HDAC4 protein]

NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164

G

hexosaminidase subunit beta

increases secretion

Vecuronium Bromide results in increased secretion of HEXB protein

NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223

G

hydroxysteroid 11-beta dehydrogenase 2

increases expression
multiple interactions

Vecuronium Bromide results in increased expression of HSD11B2 mRNA; Vecuronium Bromide results in increased expression of HSD11B2 protein
Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

mitogen activated protein kinase 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

nuclear receptor subfamily 1, group H, member 2

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H2 protein]

NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377

G

nuclear receptor subfamily 1, group H, member 3

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of NR1H3 protein]

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

G

scavenger receptor class B, member 1

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of SCARB1 protein]

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

steroidogenic acute regulatory protein

multiple interactions

Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR mRNA]; Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of STAR protein]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19932
role	19904
biological role	19902
pharmacological role	19120
neurotransmitter agent	16808
cholinergic drug	5347
cholinergic antagonist	4297
nicotinic antagonist	210
(R,R)-tramadol +	38
(R,R)-tramadol hydrochloride +	0
(S,S)-tramadol +	38
3beta-(2-diethylaminoethoxy)androst-5-en-17-one	0
3beta-(2-diethylaminoethoxy)androst-5-en-17-one hydrochloride	1
atracurium +	6
atracurium besylate +	0
cisatracurium +	11
cisatracurium besylate	0
dihydro-beta-erythroidine	17
dizocilpine	3
dizocilpine maleate	102
erysodine	0
kynurenic acid +	19
pancuronium +	11
pancuronium bromide	0
tramadol	38
tramadol hydrochloride	0
trimethaphan +	1
tubocurarine	46
vecuronium +	25
vecuronium bromide	25
Path 2
Term	Annotations
CHEBI ontology	19932
role	19904
application	19741
pharmaceutical	19579
drug	19579
neurotransmitter agent	16808
cholinergic drug	5347
cholinergic antagonist	4297
nicotinic antagonist	210
(R,R)-tramadol +	38
(R,R)-tramadol hydrochloride +	0
(S,S)-tramadol +	38
3beta-(2-diethylaminoethoxy)androst-5-en-17-one	0
3beta-(2-diethylaminoethoxy)androst-5-en-17-one hydrochloride	1
atracurium +	6
atracurium besylate +	0
cisatracurium +	11
cisatracurium besylate	0
dihydro-beta-erythroidine	17
dizocilpine	3
dizocilpine maleate	102
erysodine	0
kynurenic acid +	19
pancuronium +	11
pancuronium bromide	0
tramadol	38
tramadol hydrochloride	0
trimethaphan +	1
tubocurarine	46
vecuronium +	25
vecuronium bromide	25

paths to the root