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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethosuximide
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Accession:CHEBI:4887 term browser browse the term
Definition:A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Synonyms:exact_synonym: 3-ethyl-3-methylpyrrolidine-2,5-dione
 related_synonym: 2-ethyl-2-methylsuccinimide;   2-methyl-2-ethylsuccinimide;   3-ethyl-3-methyl-2,5-pyrrolidinedione;   3-ethyl-3-methylsuccinimide;   3-methyl-3-ethylpyrrolidine-2,5-dione;   3-methyl-3-ethylsuccinimide;   Aethosuximide;   Formula=C7H11NO2;   InChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10);   InChIKey=HAPOVYFOVVWLRS-UHFFFAOYSA-N;   SMILES=CCC1(C)CC(=O)NC1=O;   alpha-ethyl-alpha-methylsuccinimide;   alpha-methyl-alpha-ethylsuccinimide;   ethosuximidum;   etosuximida;   gamma-methyl-gamma-ethyl-succinimide
 alt_id: CHEBI:131811
 xref: CAS:77-67-8;   DrugBank:DB00593;   Drug_Central:1087;   HMDB:HMDB0014731;   KEGG:C07505;   KEGG:D00539;   LINCS:LSM-5195
 xref_mesh: MESH:D005013
 xref: PMID:12873507;   PMID:1681105;   PMID:17011080;   PMID:17046248;   PMID:17451232;   PMID:17481896;   PMID:1847429;   PMID:19005061;   PMID:1992141;   PMID:2061925;   PMID:21332949;   PMID:21945797;   PMID:2296016;   PMID:2308142;   PMID:3336019;   PMID:3820228;   PMID:8246220;   PMID:8627613;   PMID:8691481;   PMID:9016327;   Reaxys:117054;   Wikipedia:Ethosuximide


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ethosuximide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway increases expression
multiple interactions
EXP Ethosuximide results in increased expression of APC mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of APC mRNA]
CTD PMID:26420483 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of APC mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of AXIN1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of CCND1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of CTNNB1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of DCX mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of FZD1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of LEF1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of LRP6 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of NES mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of NEUROD1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of PAX6 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of STAT3 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT3 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of DKK1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of GSK3B mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of WIF1 mRNA] CTD PMID:26420483 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Axin1 axin 1 multiple interactions
increases expression
EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of AXIN1 mRNA]
Ethosuximide results in increased expression of AXIN1 mRNA
CTD PMID:26420483
G Ccnd1 cyclin D1 multiple interactions
increases expression
EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of CCND1 mRNA]
Ethosuximide results in increased expression of CCND1 mRNA
CTD PMID:26420483 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
decreases phosphorylation
EXP
ISO
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of CTNNB1 mRNA]
Ethosuximide results in increased expression of CTNNB1 mRNA
Ethosuximide results in decreased phosphorylation of CTNNB1 protein
DKK1 protein inhibits the reaction [Ethosuximide results in decreased phosphorylation of CTNNB1 protein]
CTD PMID:26420483 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Ethosuximide results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects metabolic processing EXP CYP2E1 protein affects the metabolism of Ethosuximide CTD PMID:1438522 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dcx doublecortin multiple interactions
increases expression
EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of DCX mRNA]
Ethosuximide results in increased expression of DCX mRNA
CTD PMID:26420483 NCBI chr  X:115,098,675...115,175,515
Ensembl chr  X:115,098,675...115,175,299
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions
decreases expression
ISO
EXP
DKK1 protein inhibits the reaction [Ethosuximide results in decreased phosphorylation of CTNNB1 protein]; DKK1 protein inhibits the reaction [Ethosuximide results in increased phosphorylation of GSK3B protein]
Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of DKK1 mRNA]
Ethosuximide results in decreased expression of DKK1 mRNA
CTD PMID:26420483 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Fzd1 frizzled class receptor 1 increases expression
multiple interactions
EXP Ethosuximide results in increased expression of FZD1 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of FZD1 mRNA]
CTD PMID:26420483 NCBI chr 4:26,470,864...26,475,262
Ensembl chr 4:26,470,864...26,475,262
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases expression
increases phosphorylation
EXP
ISO
Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of GSK3B mRNA]
Ethosuximide results in decreased expression of GSK3B mRNA
Ethosuximide results in increased phosphorylation of GSK3B protein
DKK1 protein inhibits the reaction [Ethosuximide results in increased phosphorylation of GSK3B protein]
CTD PMID:26420483 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions EXP
ISO
Ethosuximide inhibits the reaction [[KCNJ5 protein binds to KCNJ3 protein] which results in increased transport of Potassium]; Ethosuximide inhibits the reaction [Ethanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]]
Ethosuximide inhibits the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]
CTD PMID:18977371 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions EXP Ethosuximide inhibits the reaction [[KCNJ5 protein binds to KCNJ3 protein] which results in increased transport of Potassium] CTD PMID:18977371 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO
EXP
Ethosuximide inhibits the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]
Ethosuximide inhibits the reaction [Ethanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]]
CTD PMID:18977371 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 increases expression
multiple interactions
EXP Ethosuximide results in increased expression of LEF1 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of LEF1 mRNA]
CTD PMID:26420483 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
JBrowse link
G Lrp6 LDL receptor related protein 6 increases expression
multiple interactions
EXP Ethosuximide results in increased expression of LRP6 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of LRP6 mRNA]
CTD PMID:26420483 NCBI chr 4:168,194,054...168,323,962
Ensembl chr 4:168,194,927...168,323,751
JBrowse link
G Nes nestin increases expression
multiple interactions
EXP Ethosuximide results in increased expression of NES mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of NES mRNA]
CTD PMID:26420483 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969
JBrowse link
G Neurod1 neuronal differentiation 1 increases expression
multiple interactions
EXP Ethosuximide results in increased expression of NEUROD1 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of NEUROD1 mRNA]
CTD PMID:26420483 NCBI chr 3:66,414,314...66,417,617
Ensembl chr 3:66,414,308...66,417,741
JBrowse link
G Pax6 paired box 6 increases expression
multiple interactions
EXP Ethosuximide results in increased expression of PAX6 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of PAX6 mRNA]
CTD PMID:26420483 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624
JBrowse link
G RT1-DMb RT1 class II, locus DMb affects expression ISO Ethosuximide affects the expression of HLA-DMB mRNA CTD PMID:25811541 NCBI chr20:3,945,383...3,952,838
Ensembl chr20:5,227,045...5,234,290
Ensembl chr20:5,227,045...5,234,290
JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Ethosuximide affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:3,875,478...3,885,140
Ensembl chr20:3,875,706...3,881,461
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression
multiple interactions
EXP Ethosuximide results in increased expression of STAT3 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of STAT3 mRNA]
CTD PMID:26420483 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Wif1 Wnt inhibitory factor 1 multiple interactions EXP Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of WIF1 mRNA] CTD PMID:26420483 NCBI chr 7:63,094,955...63,165,158
Ensembl chr 7:63,094,911...63,165,159
JBrowse link
G Wnt1 Wnt family member 1 multiple interactions
increases expression
EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT1 mRNA]
Ethosuximide results in increased expression of WNT1 mRNA
CTD PMID:26420483 NCBI chr 7:140,464,999...140,469,046
Ensembl chr 7:140,464,999...140,469,046
JBrowse link
G Wnt3 Wnt family member 3 multiple interactions
increases expression
EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT3 mRNA]
Ethosuximide results in increased expression of WNT3 mRNA
CTD PMID:26420483 NCBI chr10:91,830,709...91,874,907
Ensembl chr10:91,830,654...91,874,793
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      biological role 19723
        biophysical role 12659
          membrane transport modulator 12458
            calcium channel modulator 7874
              calcium channel blocker 6616
                ethosuximide 25
                  (R)-ethosuximide 0
                  (S)-ethosuximide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic molecule 19505
                              organic cyclic compound 19332
                                organic heterocyclic compound 18519
                                  organic heteromonocyclic compound 16987
                                    pyrrolidines 2246
                                      pyrrolidinone 165
                                        ethosuximide 25
                                          (R)-ethosuximide 0
                                          (S)-ethosuximide 0
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