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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ethosuximide
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Accession:CHEBI:4887 term browser browse the term
Definition:A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Synonyms:exact_synonym: 3-ethyl-3-methylpyrrolidine-2,5-dione
 related_synonym: 2-ethyl-2-methylsuccinimide;   2-methyl-2-ethylsuccinimide;   3-ethyl-3-methyl-2,5-pyrrolidinedione;   3-ethyl-3-methylsuccinimide;   3-methyl-3-ethylpyrrolidine-2,5-dione;   3-methyl-3-ethylsuccinimide;   Aethosuximide;   Formula=C7H11NO2;   InChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10);   InChIKey=HAPOVYFOVVWLRS-UHFFFAOYSA-N;   SMILES=CCC1(C)CC(=O)NC1=O;   alpha-ethyl-alpha-methylsuccinimide;   alpha-methyl-alpha-ethylsuccinimide;   ethosuximidum;   etosuximida;   gamma-methyl-gamma-ethyl-succinimide
 alt_id: CHEBI:131811
 xref: CAS:77-67-8;   Chemspider:3175;   DrugBank:DB00593;   Drug_Central:1087;   HMDB:HMDB0014731;   KEGG:C07505;   KEGG:D00539;   LINCS:LSM-5195
 xref_mesh: MESH:D005013
 xref: PMID:12873507;   PMID:16606760;   PMID:1681105;   PMID:17011080;   PMID:17046248;   PMID:17451232;   PMID:17481896;   PMID:1847429;   PMID:18949032;   PMID:19005061;   PMID:1992141;   PMID:2061925;   PMID:21332949;   PMID:21945797;   PMID:2296016;   PMID:2308142;   PMID:3336019;   PMID:3820228;   PMID:8246220;   PMID:8627613;   PMID:8691481;   PMID:9016327;   Reaxys:117054;   Wikipedia:Ethosuximide


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ethosuximide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway increases expression
multiple interactions		 EXP Ethosuximide results in increased expression of APC mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of APC mRNA]		 CTD PMID:26420483 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of APC mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of AXIN1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of CCND1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of CTNNB1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of DCX mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of FZD1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of LEF1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of LRP6 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of NES mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of NEUROD1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of PAX6 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of STAT3 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT3 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of DKK1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of GSK3B mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of WIF1 mRNA] CTD PMID:26420483 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Axin1 axin 1 multiple interactions
increases expression		 EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of AXIN1 mRNA]
Ethosuximide results in increased expression of AXIN1 mRNA		 CTD PMID:26420483 NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression		 EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of CCND1 mRNA]
Ethosuximide results in increased expression of CCND1 mRNA		 CTD PMID:26420483 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases phosphorylation
increases expression		 EXP
ISO		 Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of CTNNB1 mRNA]
DKK1 protein inhibits the reaction [Ethosuximide results in decreased phosphorylation of CTNNB1 protein]
Ethosuximide results in increased expression of CTNNB1 mRNA		 CTD PMID:26420483 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Ethosuximide results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects metabolic processing EXP CYP2E1 protein affects the metabolism of Ethosuximide CTD PMID:1438522 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dcx doublecortin multiple interactions
increases expression		 EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of DCX mRNA]
Ethosuximide results in increased expression of DCX mRNA		 CTD PMID:26420483 NCBI chr  X:107,430,767...107,573,612
Ensembl chr  X:107,430,767...107,507,476 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions
decreases expression		 ISO
EXP		 DKK1 protein inhibits the reaction [Ethosuximide results in decreased phosphorylation of CTNNB1 protein]; DKK1 protein inhibits the reaction [Ethosuximide results in increased phosphorylation of GSK3B protein]
Ethosuximide results in decreased expression of DKK1 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of DKK1 mRNA]		 CTD PMID:26420483 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Fzd1 frizzled class receptor 1 increases expression
multiple interactions		 EXP Ethosuximide results in increased expression of FZD1 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of FZD1 mRNA]		 CTD PMID:26420483 NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643
Ensembl chr 4:29,310,091...29,312,643 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
decreases expression		 EXP
ISO		 Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of GSK3B mRNA]
DKK1 protein inhibits the reaction [Ethosuximide results in increased phosphorylation of GSK3B protein]
Ethosuximide results in decreased expression of GSK3B mRNA		 CTD PMID:26420483 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions EXP
ISO		 Ethosuximide inhibits the reaction [[KCNJ5 protein binds to KCNJ3 protein] which results in increased transport of Potassium]; Ethosuximide inhibits the reaction [Ethanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]]
Ethosuximide inhibits the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]		 CTD PMID:18977371 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124 		JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions EXP Ethosuximide inhibits the reaction [[KCNJ5 protein binds to KCNJ3 protein] which results in increased transport of Potassium] CTD PMID:18977371 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO
EXP		 Ethosuximide inhibits the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]
Ethosuximide inhibits the reaction [Ethanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]]		 CTD PMID:18977371 NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 increases expression
multiple interactions		 EXP Ethosuximide results in increased expression of LEF1 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of LEF1 mRNA]		 CTD PMID:26420483 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Lrp6 LDL receptor related protein 6 increases expression
multiple interactions		 EXP Ethosuximide results in increased expression of LRP6 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of LRP6 mRNA]		 CTD PMID:26420483 NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Nes nestin increases expression
multiple interactions		 EXP Ethosuximide results in increased expression of NES mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of NES mRNA]		 CTD PMID:26420483 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777 		JBrowse link
G Neurod1 neuronal differentiation 1 increases expression
multiple interactions		 EXP Ethosuximide results in increased expression of NEUROD1 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of NEUROD1 mRNA]		 CTD PMID:26420483 NCBI chr 3:64,359,554...64,363,526
Ensembl chr 3:64,359,395...64,363,649 		JBrowse link
G Pax6 paired box 6 increases expression
multiple interactions		 EXP Ethosuximide results in increased expression of PAX6 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of PAX6 mRNA]		 CTD PMID:26420483 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
G RT1-DMb RT1 class II, locus DMb affects expression ISO Ethosuximide affects the expression of HLA-DMB mRNA CTD PMID:25811541 NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340 		JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Ethosuximide affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:4,760,631...4,770,662
Ensembl chr20:4,760,118...4,770,244 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression
multiple interactions		 EXP Ethosuximide results in increased expression of STAT3 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of STAT3 mRNA]		 CTD PMID:26420483 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Wif1 Wnt inhibitory factor 1 multiple interactions EXP Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of WIF1 mRNA] CTD PMID:26420483 NCBI chr 7:56,548,060...56,618,364
Ensembl chr 7:56,548,053...56,618,360 		JBrowse link
G Wnt1 Wnt family member 1 multiple interactions
increases expression		 EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT1 mRNA]
Ethosuximide results in increased expression of WNT1 mRNA		 CTD PMID:26420483 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
G Wnt3 Wnt family member 3 multiple interactions
increases expression		 EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT3 mRNA]
Ethosuximide results in increased expression of WNT3 mRNA		 CTD PMID:26420483 NCBI chr10:88,680,198...88,724,170
Ensembl chr10:88,680,248...88,724,099 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      application 19630
        pharmaceutical 19503
          drug 19471
            protective agent 18183
              geroprotector 17352
                ethosuximide 25
                  (R)-ethosuximide 0
                  (S)-ethosuximide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                organic heterocyclic compound 18862
                                  organic heteromonocyclic compound 17772
                                    pyrrolidines 2317
                                      pyrrolidinone 189
                                        ethosuximide 25
                                          (R)-ethosuximide 0
                                          (S)-ethosuximide 0
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