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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethosuximide
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Accession:CHEBI:4887 term browser browse the term
Definition:A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.
Synonyms:exact_synonym: 3-ethyl-3-methylpyrrolidine-2,5-dione
 related_synonym: 2-ethyl-2-methylsuccinimide;   2-methyl-2-ethylsuccinimide;   3-ethyl-3-methyl-2,5-pyrrolidinedione;   3-ethyl-3-methylsuccinimide;   3-methyl-3-ethylpyrrolidine-2,5-dione;   3-methyl-3-ethylsuccinimide;   Aethosuximide;   Formula=C7H11NO2;   InChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10);   InChIKey=HAPOVYFOVVWLRS-UHFFFAOYSA-N;   SMILES=CCC1(C)CC(=O)NC1=O;   alpha-ethyl-alpha-methylsuccinimide;   alpha-methyl-alpha-ethylsuccinimide;   ethosuximidum;   etosuximida;   gamma-methyl-gamma-ethyl-succinimide
 alt_id: CHEBI:131811
 xref: CAS:77-67-8;   Chemspider:3175;   DrugBank:DB00593;   Drug_Central:1087;   HMDB:HMDB0014731;   KEGG:C07505;   KEGG:D00539;   LINCS:LSM-5195
 xref_mesh: MESH:D005013
 xref: PMID:12873507;   PMID:16606760;   PMID:1681105;   PMID:17011080;   PMID:17046248;   PMID:17451232;   PMID:17481896;   PMID:1847429;   PMID:18949032;   PMID:19005061;   PMID:1992141;   PMID:2061925;   PMID:21332949;   PMID:21945797;   PMID:2296016;   PMID:2308142;   PMID:3336019;   PMID:3820228;   PMID:8246220;   PMID:8627613;   PMID:8691481;   PMID:9016327;   Reaxys:117054;   Wikipedia:Ethosuximide



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ethosuximide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway increases expression
multiple interactions
EXP Ethosuximide results in increased expression of APC mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of APC mRNA]
CTD PMID:26420483 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of APC mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of AXIN1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of CCND1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of CTNNB1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of DCX mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of FZD1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of LEF1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of LRP6 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of NES mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of NEUROD1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of PAX6 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of STAT3 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT3 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of DKK1 mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of GSK3B mRNA]; Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of WIF1 mRNA] CTD PMID:26420483 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Axin1 axin 1 multiple interactions
increases expression
EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of AXIN1 mRNA]
Ethosuximide results in increased expression of AXIN1 mRNA
CTD PMID:26420483 NCBI chr10:15,163,684...15,215,615
Ensembl chr10:15,163,684...15,215,615
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of CCND1 mRNA]
Ethosuximide results in increased expression of CCND1 mRNA
CTD PMID:26420483 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
decreases phosphorylation
EXP
ISO
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of CTNNB1 mRNA]
Ethosuximide results in increased expression of CTNNB1 mRNA
Ethosuximide results in decreased phosphorylation of CTNNB1 protein
DKK1 protein inhibits the reaction [Ethosuximide results in decreased phosphorylation of CTNNB1 protein]
CTD PMID:26420483 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Ethosuximide results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects metabolic processing EXP CYP2E1 protein affects the metabolism of Ethosuximide CTD PMID:1438522 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Dcx doublecortin multiple interactions
increases expression
EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of DCX mRNA]
Ethosuximide results in increased expression of DCX mRNA
CTD PMID:26420483 NCBI chr  X:107,430,767...107,573,612
Ensembl chr  X:107,430,767...107,507,476
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions
decreases expression
ISO
EXP
DKK1 protein inhibits the reaction [Ethosuximide results in decreased phosphorylation of CTNNB1 protein]; DKK1 protein inhibits the reaction [Ethosuximide results in increased phosphorylation of GSK3B protein]
Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of DKK1 mRNA]
Ethosuximide results in decreased expression of DKK1 mRNA
CTD PMID:26420483 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
G Fzd1 frizzled class receptor 1 increases expression
multiple interactions
EXP Ethosuximide results in increased expression of FZD1 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of FZD1 mRNA]
CTD PMID:26420483 NCBI chr 4:29,310,303...29,314,701 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases expression
increases phosphorylation
EXP
ISO
Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of GSK3B mRNA]
Ethosuximide results in decreased expression of GSK3B mRNA
Ethosuximide results in increased phosphorylation of GSK3B protein
DKK1 protein inhibits the reaction [Ethosuximide results in increased phosphorylation of GSK3B protein]
CTD PMID:26420483 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions EXP
ISO
Ethosuximide inhibits the reaction [[KCNJ5 protein binds to KCNJ3 protein] which results in increased transport of Potassium]; Ethosuximide inhibits the reaction [Ethanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]]
Ethosuximide inhibits the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]
CTD PMID:18977371 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions EXP Ethosuximide inhibits the reaction [[KCNJ5 protein binds to KCNJ3 protein] which results in increased transport of Potassium] CTD PMID:18977371 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO
EXP
Ethosuximide inhibits the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]
Ethosuximide inhibits the reaction [Ethanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]]
CTD PMID:18977371 NCBI chr11:34,061,705...34,309,128
Ensembl chr11:34,061,708...34,308,758
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 increases expression
multiple interactions
EXP Ethosuximide results in increased expression of LEF1 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of LEF1 mRNA]
CTD PMID:26420483 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G Lrp6 LDL receptor related protein 6 increases expression
multiple interactions
EXP Ethosuximide results in increased expression of LRP6 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of LRP6 mRNA]
CTD PMID:26420483 NCBI chr 4:167,266,581...167,400,155
Ensembl chr 4:167,270,353...167,400,497
JBrowse link
G Nes nestin increases expression
multiple interactions
EXP Ethosuximide results in increased expression of NES mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of NES mRNA]
CTD PMID:26420483 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Neurod1 neuronal differentiation 1 increases expression
multiple interactions
EXP Ethosuximide results in increased expression of NEUROD1 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of NEUROD1 mRNA]
CTD PMID:26420483 NCBI chr 3:64,360,222...64,363,526
Ensembl chr 3:64,359,395...64,363,649
JBrowse link
G Pax6 paired box 6 increases expression
multiple interactions
EXP Ethosuximide results in increased expression of PAX6 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of PAX6 mRNA]
CTD PMID:26420483 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
G RT1-DMb RT1 class II, locus DMb affects expression ISO Ethosuximide affects the expression of HLA-DMB mRNA CTD PMID:25811541 NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340
JBrowse link
G RT1-Ha RT1 class II, locus Ha affects expression ISO Ethosuximide affects the expression of HLA-DPA1 mRNA CTD PMID:25811541 NCBI chr20:4,760,631...4,770,662 JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression
multiple interactions
EXP Ethosuximide results in increased expression of STAT3 mRNA
Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of STAT3 mRNA]
CTD PMID:26420483 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Wif1 Wnt inhibitory factor 1 multiple interactions EXP Ethosuximide inhibits the reaction [APP protein modified form results in increased expression of WIF1 mRNA] CTD PMID:26420483 NCBI chr 7:56,548,058...56,618,364
Ensembl chr 7:56,548,053...56,618,360
JBrowse link
G Wnt1 Wnt family member 1 multiple interactions
increases expression
EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT1 mRNA]
Ethosuximide results in increased expression of WNT1 mRNA
CTD PMID:26420483 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link
G Wnt3 Wnt family member 3 multiple interactions
increases expression
EXP Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of WNT3 mRNA]
Ethosuximide results in increased expression of WNT3 mRNA
CTD PMID:26420483 NCBI chr10:88,680,248...88,724,170
Ensembl chr10:88,680,248...88,724,099
JBrowse link

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  CHEBI ontology 19795
    role 19746
      application 19492
        pharmaceutical 19351
          drug 19351
            protective agent 17738
              geroprotector 16519
                ethosuximide 25
                  (R)-ethosuximide 0
                  (S)-ethosuximide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic molecule 19545
                              organic cyclic compound 19339
                                organic heterocyclic compound 18579
                                  organic heteromonocyclic compound 17121
                                    pyrrolidines 2267
                                      pyrrolidinone 166
                                        ethosuximide 25
                                          (R)-ethosuximide 0
                                          (S)-ethosuximide 0
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