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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alkyloxynaphthalene
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Accession:CHEBI:48850 term browser browse the term
Definition:Naphthalenes in which one or more alkyloxy groups are bonded to a naphthalene ring system.
Synonyms:related_synonym: alkoxynaphthalenes;   alkyloxynaphthalenes


show annotations for term's descendants           Sort by:
nabumetone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO nabumetone results in decreased expression of BCL2 protein CTD PMID:16019514 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO nabumetone results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO nabumetone results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity EXP nabumetone metabolite results in decreased activity of PTGS1 protein CTD PMID:9258749 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity EXP nabumetone metabolite results in decreased activity of PTGS2 protein CTD PMID:9258749 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Sell selectin L affects expression ISO nabumetone affects the expression of SELL protein CTD PMID:12147693 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600 		JBrowse link
G Utrn utrophin increases expression ISO nabumetone results in increased expression of UTRN mRNA; nabumetone results in increased expression of UTRN protein CTD PMID:22028826 NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:8,542,798...9,044,487 		JBrowse link
naproxen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity 		ISO Naproxen inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Naproxen results in decreased activity of ABCB11 protein 		CTD PMID:24014644 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects expression ISO Naproxen affects the expression of ABCB1 mRNA CTD PMID:18581209 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects expression
affects activity 		ISO Naproxen affects the expression of ABCG2 protein
Naproxen affects the activity of ABCG2 protein 		CTD PMID:18581209 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Naproxen results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Naproxen results in increased expression of ADIPOQ protein CTD PMID:23784744 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Naproxen results in decreased activity of AKR1C1 protein CTD PMID:19010312 NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Naproxen results in decreased activity of AKR1C2 protein CTD PMID:19010312 NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Naproxen results in decreased activity of AKR1C3 protein CTD PMID:19010312 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438 		JBrowse link
G Alb albumin affects binding ISO
EXP 		[Naproxen binds to Cobalt] which binds to ALB protein; Naproxen binds to ALB protein CTD PMID:9353694 PMID:22178666 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Bace1 beta-secretase 1 decreases expression ISO Naproxen results in decreased expression of BACE1 mRNA CTD PMID:16407166 NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of BDNF protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of BDNF protein] CTD PMID:22150557 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Cat catalase decreases expression EXP Naproxen results in decreased expression of CAT protein CTD PMID:25034942 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CCL2 protein] CTD PMID:22150557 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CCL20 protein] CTD PMID:22150557 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CCL22 protein] CTD PMID:22150557 NCBI chr19:10,263,589...10,270,359
Ensembl chr19:10,263,589...10,270,359 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL3 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CCL3 protein] CTD PMID:22150557 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Naproxen inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:15489888 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCR4 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CCR4 protein] CTD PMID:22150557 NCBI chr 8:123,054,505...123,060,244
Ensembl chr 8:123,054,324...123,077,642 		JBrowse link
G Cd80 Cd80 molecule multiple interactions EXP [Naproxen co-treated with Sumatriptan] affects the reaction [Capsaicin results in increased expression of CD80 protein]; Naproxen affects the reaction [Capsaicin results in increased expression of CD80 protein] CTD PMID:22150557 NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540 		JBrowse link
G Cilk1 ciliogenesis associated kinase 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CILK1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CILK1 protein] CTD PMID:22150557 NCBI chr 8:87,868,294...87,922,995
Ensembl chr 8:87,868,156...87,922,995 		JBrowse link
G Cntf ciliary neurotrophic factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTF protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CNTF protein] CTD PMID:22150557 NCBI chr 1:219,312,512...219,314,535
Ensembl chr 1:219,312,512...219,314,488 		JBrowse link
G Cntfr ciliary neurotrophic factor receptor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTFR protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CNTFR protein] CTD PMID:22150557 NCBI chr 5:61,619,326...61,657,359
Ensembl chr 5:61,619,326...61,645,795 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CSF2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CSF2 protein] CTD PMID:22150557 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CTNNB1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CTNNB1 protein] CTD PMID:22150557 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein] CTD PMID:22150557 NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL10 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CXCL10 protein] CTD PMID:22150557 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CXCL2 protein] CTD PMID:22150557 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein] CTD PMID:22150557 NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of ERRFI1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of ERRFI1 protein] CTD PMID:22150557 NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:166,606,834...166,620,432 		JBrowse link
G Fadd Fas associated via death domain multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FADD protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of FADD protein] CTD PMID:22150557 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FAS protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of FAS protein] CTD PMID:22150557 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Faslg Fas ligand multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FASLG protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of FASLG protein] CTD PMID:22150557 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Fgfbp1 fibroblast growth factor binding protein 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein] CTD PMID:22150557 NCBI chr14:71,316,171...71,319,965
Ensembl chr14:71,317,065...71,320,309 		JBrowse link
G Fgl1 fibrinogen-like 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FGL1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of FGL1 protein] CTD PMID:22150557 NCBI chr16:57,824,127...57,854,413
Ensembl chr16:57,824,200...57,854,429 		JBrowse link
G Fstl1 follistatin-like 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein] CTD PMID:22150557 NCBI chr11:76,400,870...76,454,053
Ensembl chr11:76,391,315...76,455,126 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Naproxen results in increased expression of GCLC mRNA CTD PMID:11909699 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Naproxen results in increased expression of GCLM mRNA CTD PMID:11909699 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003 		JBrowse link
G Gfra1 GDNF family receptor alpha 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of GFRA1 protein] CTD PMID:22150557 NCBI chr 1:267,325,297...267,557,037
Ensembl chr 1:267,326,817...267,556,501 		JBrowse link
G Gfra2 GDNF family receptor alpha 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA2 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of GFRA2 protein] CTD PMID:22150557 NCBI chr15:52,351,499...52,443,369
Ensembl chr15:52,351,514...52,477,782 		JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GH1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of GH1 protein] CTD PMID:22150557 NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,727,884...91,729,859 		JBrowse link
G Ghr growth hormone receptor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GHR protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of GHR protein] CTD PMID:22150557 NCBI chr 2:54,269,066...54,532,595
Ensembl chr 2:54,270,206...54,532,331 		JBrowse link
G Hcrt hypocretin neuropeptide precursor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of HCRT protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of HCRT protein] CTD PMID:22150557 NCBI chr10:86,190,289...86,191,524
Ensembl chr10:86,189,775...86,191,524 		JBrowse link
G Ide insulin degrading enzyme multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IDE protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of IDE protein] CTD PMID:22150557 NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:244,416,343...244,514,526 		JBrowse link
G Ifng interferon gamma multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IFNG protein]; Naproxen inhibits the reaction [Capsaicin results in decreased expression of IFNG protein] CTD PMID:22150557 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL10 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL10 protein] CTD PMID:22150557 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580 		JBrowse link
G Il13 interleukin 13 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL13 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL13 protein] CTD PMID:22150557 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IL1A protein]; Naproxen inhibits the reaction [Capsaicin results in decreased expression of IL1A protein] CTD PMID:22150557 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP 		Naproxen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Naproxen promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Naproxen promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; tert-Butylhydroperoxide inhibits the reaction [Naproxen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL1B protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of IL1B protein] 		CTD PMID:14762100 PMID:15705740 PMID:22150557 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL2 protein] CTD PMID:22150557 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Il3 interleukin 3 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL3 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of IL3 protein] CTD PMID:22150557 NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,906,460...38,908,810 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL4 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL4 protein] CTD PMID:22150557 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il5 interleukin 5 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL5 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL5 protein] CTD PMID:22150557 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL6 protein] CTD PMID:22150557 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Inhba inhibin subunit beta A multiple interactions EXP Naproxen inhibits the reaction [Capsaicin results in increased expression of INHBA protein] CTD PMID:22150557 NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508 		JBrowse link
G Ins1 insulin 1 increases expression
multiple interactions 		ISO
EXP 		Naproxen results in increased expression of INS1 protein
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of INS1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of INS1 protein] 		CTD PMID:22150557 PMID:23784744 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Lep leptin multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of LEP protein] CTD PMID:22150557 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MIF protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of MIF protein] CTD PMID:22150557 NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121
Ensembl chr20:134,041,774...134,042,121 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of MMP13 protein] CTD PMID:22150557 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of MMP2 protein] CTD PMID:22150557 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to Naproxen CTD PMID:28754375 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Musk muscle associated receptor tyrosine kinase multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MUSK protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of MUSK protein] CTD PMID:22150557 NCBI chr 5:77,853,560...77,967,653
Ensembl chr 5:77,853,736...77,964,338 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Naproxen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Naproxen inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15489888 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGF protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of NGF protein] CTD PMID:22150557 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Ngfr nerve growth factor receptor increases expression
multiple interactions 		ISO
EXP 		Naproxen results in increased expression of NGFR protein
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGFR protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of NGFR protein] 		CTD PMID:17409433 PMID:22150557 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Naproxen results in increased expression of NOS2 mRNA CTD PMID:16944022 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nrp1 neuropilin 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of NRP1 protein] CTD PMID:22150557 NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702 		JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of PDGFA protein] CTD PMID:22150557 NCBI chr12:20,759,366...20,780,337
Ensembl chr12:20,754,208...20,780,322 		JBrowse link
G Plin2 perilipin 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of PLIN2 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of PLIN2 protein] CTD PMID:22150557 NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878 		JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of POMC protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of POMC protein] CTD PMID:22150557 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity EXP Naproxen results in increased activity of PPARA protein CTD PMID:11755111 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity EXP Naproxen results in increased activity of PPARG protein CTD PMID:11755111 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein] CTD PMID:22150557 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450 		JBrowse link
G Prlr prolactin receptor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRLR protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of PRLR protein] CTD PMID:22150557 NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882 		JBrowse link
G Prok1 prokineticin 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of PROK1 protein] CTD PMID:22150557 NCBI chr 2:197,538,747...197,547,550
Ensembl chr 2:197,537,068...197,547,550 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO
EXP 		Naproxen results in decreased activity of PTGS1 protein CTD PMID:9258749 PMID:17164136 PMID:25034942 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
increases expression 		ISO
EXP 		Naproxen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Naproxen inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; tert-Butylhydroperoxide inhibits the reaction [Naproxen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
Naproxen results in decreased activity of PTGS2 protein
Naproxen results in increased expression of PTGS2 		CTD PMID:9258749 PMID:11840453 PMID:15489888 PMID:15705740 PMID:17164136 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Naproxen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Naproxen inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:15489888 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Ren renin decreases activity ISO Naproxen results in decreased activity of REN protein CTD PMID:2203262 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Retn resistin multiple interactions
decreases expression 		EXP
ISO 		[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of RETN protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of RETN protein]
Naproxen results in decreased expression of RETN protein 		CTD PMID:22150557 PMID:23784744 NCBI chr12:6,508,653...6,511,115
Ensembl chr12:6,508,801...6,511,116 		JBrowse link
G Retnlb resistin like beta multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of RETNLB protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of RETNLB protein] CTD PMID:22150557 NCBI chr11:65,446,433...65,448,319
Ensembl chr11:65,446,434...65,448,319 		JBrowse link
G RT1-DMb RT1 class II, locus DMb affects expression ISO Naproxen affects the expression of HLA-DMB mRNA CTD PMID:25811541 NCBI chr20:4,695,009...4,702,560
Ensembl chr20:4,695,010...4,702,246 		JBrowse link
G Sele selectin E multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELE protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of SELE protein] CTD PMID:22150557 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903 		JBrowse link
G Sell selectin L multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELL protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of SELL protein] CTD PMID:22150557 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO Naproxen results in decreased activity of SLC22A2 protein CTD PMID:12388633 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases activity ISO Naproxen results in decreased activity of SLC22A9 protein CTD PMID:12388633 NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:214,767,837...214,862,340 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO Naproxen results in decreased activity of SLC22A6 protein CTD PMID:12388633 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases activity ISO Naproxen results in decreased activity of SLC22A7 protein CTD PMID:12388633 NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 multiple interactions
decreases activity 		EXP Naproxen inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide]
Naproxen results in decreased activity of SLCO1A1 protein 		CTD PMID:11883641 NCBI chr 4:176,606,924...176,682,027
Ensembl chr 4:176,607,687...176,681,992 		JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 multiple interactions ISO Naproxen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone] CTD PMID:19843975 NCBI chr 8:112,467,739...112,551,923
Ensembl chr 8:112,467,160...112,551,921 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SPP1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of SPP1 protein] CTD PMID:22150557 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TAL1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TAL1 protein] CTD PMID:22150557 NCBI chr 5:133,823,093...133,837,737
Ensembl chr 5:133,826,003...133,837,738 		JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TEK protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TEK protein] CTD PMID:22150557 NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:114,723,006...114,849,991 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TGFB1 protein] CTD PMID:22150557 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein] CTD PMID:22150557 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein] CTD PMID:22150557 NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TIMP1 protein] CTD PMID:22150557 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein] CTD PMID:22150557 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein] CTD PMID:22150557 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TLR4 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TLR4 protein] CTD PMID:22150557 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		Naproxen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Naproxen inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Naproxen inhibits the reaction [TNF protein results in increased activity of RELA protein]; Naproxen inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Naproxen inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TNF protein] 		CTD PMID:15489888 PMID:22150557 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf19 TNF receptor superfamily member 19 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of TNFRSF19 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of TNFRSF19 protein] CTD PMID:22150557 NCBI chr15:39,268,305...39,334,566
Ensembl chr15:39,268,305...39,356,438 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TNFSF10 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TNFSF10 protein] CTD PMID:22150557 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 decreases activity
increases glucuronidation 		ISO Naproxen results in decreased activity of UGT1A1 protein
UGT1A1 protein results in increased glucuronidation of Naproxen 		CTD PMID:15593333 PMID:15843492 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Naproxen CTD PMID:15535975 PMID:15843492 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Naproxen CTD PMID:15843492 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Naproxen CTD PMID:15535975 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of Naproxen CTD PMID:8302279 NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation 		ISO Naproxen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Naproxen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]
UGT2B7 protein alternative form results in increased glucuronidation of Naproxen; UGT2B7 protein results in increased glucuronidation of Naproxen 		CTD PMID:8423545 PMID:8517101 PMID:15535975 PMID:15843492 PMID:19740398 NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of VCAM1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of VCAM1 protein] CTD PMID:22150557 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of VEGFA protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of VEGFA protein] CTD PMID:22150557 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Zfp866 zinc finger protein 866 multiple interactions EXP [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL5 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CXCL5 protein] CTD PMID:22150557 NCBI chr16:19,687,869...19,710,407
Ensembl chr16:19,702,297...19,709,330 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20873
    chemical entity 20871
      molecular entity 20870
        polyatomic entity 20815
          molecule 20686
            cyclic compound 20441
              bicyclic compound 17599
                carbobicyclic compound 5954
                  naphthalenes 3918
                    alkyloxynaphthalene 115
                      7-\{2-hydroxy-3-[(naphthalen-1-yl)oxy]propyl\}-3-methyl-8-(morpholin-4-yl)-3,7-dihydropurine-2,6-dione 0
                      methoxynaphthalene + 115
Path 2
Term Annotations click to browse term
  CHEBI ontology 20873
    subatomic particle 20871
      composite particle 20871
        hadron 20871
          baryon 20871
            nucleon 20871
              atomic nucleus 20871
                atom 20871
                  main group element atom 20794
                    p-block element atom 20794
                      carbon group element atom 20727
                        carbon atom 20722
                          organic molecular entity 20722
                            organic molecule 20666
                              organic cyclic compound 20416
                                carbocyclic compound 18962
                                  carbopolycyclic compound 17261
                                    carbobicyclic compound 5954
                                      naphthalenes 3918
                                        alkyloxynaphthalene 115
                                          7-\{2-hydroxy-3-[(naphthalen-1-yl)oxy]propyl\}-3-methyl-8-(morpholin-4-yl)-3,7-dihydropurine-2,6-dione 0
                                          methoxynaphthalene + 115
paths to the root