|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
decreases expression
|
ISO
|
nabumetone results in decreased expression of BCL2 protein
|
CTD |
PMID:16019514 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
increases expression
|
ISO
|
nabumetone results in increased expression of FOS mRNA
|
CTD |
PMID:12730611 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
|
|
G
|
Nr1i2
|
nuclear receptor subfamily 1, group I, member 2
|
increases activity
|
ISO
|
nabumetone results in increased activity of NR1I2 protein
|
CTD |
PMID:25455453 |
|
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
|
|
G
|
Ptgs1
|
prostaglandin-endoperoxide synthase 1
|
decreases activity
|
EXP
|
nabumetone metabolite results in decreased activity of PTGS1 protein
|
CTD |
PMID:9258749 |
|
NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
decreases activity
|
EXP
|
nabumetone metabolite results in decreased activity of PTGS2 protein
|
CTD |
PMID:9258749 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
|
|
G
|
Sell
|
selectin L
|
affects expression
|
ISO
|
nabumetone affects the expression of SELL protein
|
CTD |
PMID:12147693 |
|
NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600
|
|
G
|
Utrn
|
utrophin
|
increases expression
|
ISO
|
nabumetone results in increased expression of UTRN mRNA; nabumetone results in increased expression of UTRN protein
|
CTD |
PMID:22028826 |
|
NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:8,542,798...9,044,487
|
|
|
G
|
Abcb11
|
ATP binding cassette subfamily B member 11
|
multiple interactions decreases activity
|
ISO
|
Naproxen inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Naproxen results in decreased activity of ABCB11 protein
|
CTD |
PMID:24014644 |
|
NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581
|
|
G
|
Abcb1a
|
ATP binding cassette subfamily B member 1A
|
affects expression
|
ISO
|
Naproxen affects the expression of ABCB1 mRNA
|
CTD |
PMID:18581209 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
|
|
G
|
Abcg2
|
ATP binding cassette subfamily G member 2
|
affects expression affects activity
|
ISO
|
Naproxen affects the expression of ABCG2 protein Naproxen affects the activity of ABCG2 protein
|
CTD |
PMID:18581209 |
|
NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493
|
|
G
|
Ace2
|
angiotensin converting enzyme 2
|
decreases expression
|
ISO
|
Naproxen results in decreased expression of ACE2 mRNA
|
CTD |
PMID:32808185 |
|
NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596
|
|
G
|
Adipoq
|
adiponectin, C1Q and collagen domain containing
|
increases expression
|
ISO
|
Naproxen results in increased expression of ADIPOQ protein
|
CTD |
PMID:23784744 |
|
NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169
|
|
G
|
Akr1c1
|
aldo-keto reductase family 1, member C1
|
decreases activity
|
ISO
|
Naproxen results in decreased activity of AKR1C1 protein
|
CTD |
PMID:19010312 |
|
NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247
|
|
G
|
Akr1c2
|
aldo-keto reductase family 1, member C2
|
decreases activity
|
ISO
|
Naproxen results in decreased activity of AKR1C2 protein
|
CTD |
PMID:19010312 |
|
NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686
|
|
G
|
Akr1c3
|
aldo-keto reductase family 1, member C3
|
decreases activity
|
ISO
|
Naproxen results in decreased activity of AKR1C3 protein
|
CTD |
PMID:19010312 |
|
NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438
|
|
G
|
Alb
|
albumin
|
affects binding
|
ISO EXP
|
[Naproxen binds to Cobalt] which binds to ALB protein; Naproxen binds to ALB protein
|
CTD |
PMID:9353694 PMID:22178666 |
|
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
|
|
G
|
Bace1
|
beta-secretase 1
|
decreases expression
|
ISO
|
Naproxen results in decreased expression of BACE1 mRNA
|
CTD |
PMID:16407166 |
|
NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918
|
|
G
|
Bdnf
|
brain-derived neurotrophic factor
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of BDNF protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of BDNF protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
|
|
G
|
Cat
|
catalase
|
decreases expression
|
EXP
|
Naproxen results in decreased expression of CAT protein
|
CTD |
PMID:25034942 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Ccl2
|
C-C motif chemokine ligand 2
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CCL2 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
|
|
G
|
Ccl20
|
C-C motif chemokine ligand 20
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CCL20 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736
|
|
G
|
Ccl22
|
C-C motif chemokine ligand 22
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CCL22 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr19:10,263,589...10,270,359
Ensembl chr19:10,263,589...10,270,359
|
|
G
|
Ccl3
|
C-C motif chemokine ligand 3
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCL3 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CCL3 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439
|
|
G
|
Ccnd1
|
cyclin D1
|
multiple interactions
|
ISO
|
Naproxen inhibits the reaction [TNF protein results in increased expression of CCND1 protein]
|
CTD |
PMID:15489888 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
|
|
G
|
Ccr4
|
C-C motif chemokine receptor 4
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CCR4 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CCR4 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 8:123,054,505...123,060,244
Ensembl chr 8:123,054,324...123,077,642
|
|
G
|
Cd80
|
Cd80 molecule
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] affects the reaction [Capsaicin results in increased expression of CD80 protein]; Naproxen affects the reaction [Capsaicin results in increased expression of CD80 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr11:75,760,073...75,798,978
Ensembl chr11:75,760,147...75,797,540
|
|
G
|
Cilk1
|
ciliogenesis associated kinase 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CILK1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CILK1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 8:87,868,294...87,922,995
Ensembl chr 8:87,868,156...87,922,995
|
|
G
|
Cntf
|
ciliary neurotrophic factor
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTF protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CNTF protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 1:219,312,512...219,314,535
Ensembl chr 1:219,312,512...219,314,488
|
|
G
|
Cntfr
|
ciliary neurotrophic factor receptor
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTFR protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CNTFR protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 5:61,619,326...61,657,359
Ensembl chr 5:61,619,326...61,645,795
|
|
G
|
Csf2
|
colony stimulating factor 2
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CSF2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CSF2 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031
|
|
G
|
Ctnnb1
|
catenin beta 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CTNNB1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CTNNB1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
|
|
G
|
Cx3cl1
|
C-X3-C motif chemokine ligand 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of CX3CL1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999
|
|
G
|
Cxcl10
|
C-X-C motif chemokine ligand 10
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL10 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CXCL10 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261
|
|
G
|
Cxcl2
|
C-X-C motif chemokine ligand 2
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CXCL2 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255
|
|
G
|
Cxcr4
|
C-X-C motif chemokine receptor 4
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CXCR4 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459
|
|
G
|
Errfi1
|
ERBB receptor feedback inhibitor 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of ERRFI1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of ERRFI1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:166,606,834...166,620,432
|
|
G
|
Fadd
|
Fas associated via death domain
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FADD protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of FADD protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976
|
|
G
|
Fas
|
Fas cell surface death receptor
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FAS protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of FAS protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
|
|
G
|
Faslg
|
Fas ligand
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FASLG protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of FASLG protein]
|
CTD |
PMID:22150557 |
|
NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503
|
|
G
|
Fgfbp1
|
fibroblast growth factor binding protein 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of FGFBP1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr14:71,316,171...71,319,965
Ensembl chr14:71,317,065...71,320,309
|
|
G
|
Fgl1
|
fibrinogen-like 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FGL1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of FGL1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr16:57,824,127...57,854,413
Ensembl chr16:57,824,200...57,854,429
|
|
G
|
Fstl1
|
follistatin-like 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of FSTL1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr11:76,400,870...76,454,053
Ensembl chr11:76,391,315...76,455,126
|
|
G
|
Gclc
|
glutamate-cysteine ligase, catalytic subunit
|
increases expression
|
ISO
|
Naproxen results in increased expression of GCLC mRNA
|
CTD |
PMID:11909699 |
|
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
|
|
G
|
Gclm
|
glutamate cysteine ligase, modifier subunit
|
increases expression
|
ISO
|
Naproxen results in increased expression of GCLM mRNA
|
CTD |
PMID:11909699 |
|
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
|
|
G
|
Gfra1
|
GDNF family receptor alpha 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of GFRA1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 1:267,325,297...267,557,037
Ensembl chr 1:267,326,817...267,556,501
|
|
G
|
Gfra2
|
GDNF family receptor alpha 2
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of GFRA2 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of GFRA2 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr15:52,351,499...52,443,369
Ensembl chr15:52,351,514...52,477,782
|
|
G
|
Gh1
|
growth hormone 1
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GH1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of GH1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,727,884...91,729,859
|
|
G
|
Ghr
|
growth hormone receptor
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GHR protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of GHR protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 2:54,269,066...54,532,595
Ensembl chr 2:54,270,206...54,532,331
|
|
G
|
Hcrt
|
hypocretin neuropeptide precursor
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of HCRT protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of HCRT protein]
|
CTD |
PMID:22150557 |
|
NCBI chr10:86,190,289...86,191,524
Ensembl chr10:86,189,775...86,191,524
|
|
G
|
Ide
|
insulin degrading enzyme
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IDE protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of IDE protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:244,416,343...244,514,526
|
|
G
|
Ifng
|
interferon gamma
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IFNG protein]; Naproxen inhibits the reaction [Capsaicin results in decreased expression of IFNG protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
|
|
G
|
Il10
|
interleukin 10
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL10 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL10 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
|
|
G
|
Il13
|
interleukin 13
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL13 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL13 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483
|
|
G
|
Il1a
|
interleukin 1 alpha
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in decreased expression of IL1A protein]; Naproxen inhibits the reaction [Capsaicin results in decreased expression of IL1A protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
ISO EXP
|
Naproxen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Naproxen promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Naproxen promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; tert-Butylhydroperoxide inhibits the reaction [Naproxen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]] [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL1B protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of IL1B protein]
|
CTD |
PMID:14762100 PMID:15705740 PMID:22150557 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Il2
|
interleukin 2
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL2 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
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G
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Il3
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interleukin 3
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL3 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of IL3 protein]
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CTD |
PMID:22150557 |
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NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,906,460...38,908,810
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G
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Il4
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interleukin 4
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL4 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL4 protein]
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CTD |
PMID:22150557 |
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NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
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G
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Il5
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interleukin 5
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL5 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL5 protein]
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CTD |
PMID:22150557 |
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NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003
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G
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Il6
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interleukin 6
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of IL6 protein]
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CTD |
PMID:22150557 |
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
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G
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Inhba
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inhibin subunit beta A
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multiple interactions
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EXP
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Naproxen inhibits the reaction [Capsaicin results in increased expression of INHBA protein]
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CTD |
PMID:22150557 |
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NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508
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G
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Ins1
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insulin 1
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increases expression multiple interactions
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ISO EXP
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Naproxen results in increased expression of INS1 protein [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of INS1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of INS1 protein]
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CTD |
PMID:22150557 PMID:23784744 |
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NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
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G
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Lep
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leptin
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of LEP protein]
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CTD |
PMID:22150557 |
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NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
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G
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Mif
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macrophage migration inhibitory factor
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MIF protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of MIF protein]
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CTD |
PMID:22150557 |
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NCBI chr20:12,767,138...12,791,222
Ensembl chr 4:134,041,774...134,042,121 Ensembl chr20:134,041,774...134,042,121
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G
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Mmp13
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matrix metallopeptidase 13
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]
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CTD |
PMID:22150557 |
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NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105
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G
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Mmp2
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matrix metallopeptidase 2
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of MMP2 protein]
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CTD |
PMID:22150557 |
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NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
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G
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Mpo
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myeloperoxidase
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multiple interactions
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ISO
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[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of and results in increased susceptibility to Naproxen
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CTD |
PMID:28754375 |
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NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
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G
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Musk
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muscle associated receptor tyrosine kinase
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MUSK protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of MUSK protein]
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CTD |
PMID:22150557 |
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NCBI chr 5:77,853,560...77,967,653
Ensembl chr 5:77,853,736...77,964,338
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G
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Nfkb1
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nuclear factor kappa B subunit 1
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multiple interactions
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ISO
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Naproxen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Naproxen inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
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CTD |
PMID:15489888 |
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NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
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G
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Ngf
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nerve growth factor
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGF protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of NGF protein]
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CTD |
PMID:22150557 |
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NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
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G
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Ngfr
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nerve growth factor receptor
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increases expression multiple interactions
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ISO EXP
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Naproxen results in increased expression of NGFR protein [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NGFR protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of NGFR protein]
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CTD |
PMID:17409433 PMID:22150557 |
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NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305
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G
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Nos2
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nitric oxide synthase 2
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increases expression
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EXP
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Naproxen results in increased expression of NOS2 mRNA
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CTD |
PMID:16944022 |
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NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
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G
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Nrp1
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neuropilin 1
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of NRP1 protein]
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CTD |
PMID:22150557 |
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NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702
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G
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Pdgfa
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platelet derived growth factor subunit A
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]
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CTD |
PMID:22150557 |
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NCBI chr12:20,759,366...20,780,337
Ensembl chr12:20,754,208...20,780,322
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G
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Plin2
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perilipin 2
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of PLIN2 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of PLIN2 protein]
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CTD |
PMID:22150557 |
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NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878
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G
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Pomc
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proopiomelanocortin
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of POMC protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of POMC protein]
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CTD |
PMID:22150557 |
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NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
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G
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Ppara
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peroxisome proliferator activated receptor alpha
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increases activity
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EXP
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Naproxen results in increased activity of PPARA protein
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CTD |
PMID:11755111 |
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NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714
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G
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Pparg
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peroxisome proliferator-activated receptor gamma
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increases activity
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EXP
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Naproxen results in increased activity of PPARG protein
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CTD |
PMID:11755111 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
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G
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Prkaa1
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protein kinase AMP-activated catalytic subunit alpha 1
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multiple interactions
|
EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of PRKAA1 protein]
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CTD |
PMID:22150557 |
|
NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450
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G
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Prlr
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prolactin receptor
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PRLR protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of PRLR protein]
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CTD |
PMID:22150557 |
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NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882
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G
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Prok1
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prokineticin 1
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]
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CTD |
PMID:22150557 |
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NCBI chr 2:197,538,747...197,547,550
Ensembl chr 2:197,537,068...197,547,550
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G
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Ptgs1
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prostaglandin-endoperoxide synthase 1
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decreases activity
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ISO EXP
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Naproxen results in decreased activity of PTGS1 protein
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CTD |
PMID:9258749 PMID:17164136 PMID:25034942 |
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NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990
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G
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Ptgs2
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prostaglandin-endoperoxide synthase 2
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multiple interactions decreases activity increases expression
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ISO EXP
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Naproxen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Naproxen inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; tert-Butylhydroperoxide inhibits the reaction [Naproxen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]] Naproxen results in decreased activity of PTGS2 protein Naproxen results in increased expression of PTGS2
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CTD |
PMID:9258749 PMID:11840453 PMID:15489888 PMID:15705740 PMID:17164136 |
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NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
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G
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Rela
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RELA proto-oncogene, NF-kB subunit
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multiple interactions
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ISO
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Naproxen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Naproxen inhibits the reaction [TNF protein results in increased activity of RELA protein]
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CTD |
PMID:15489888 |
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NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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G
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Ren
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renin
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decreases activity
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ISO
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Naproxen results in decreased activity of REN protein
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CTD |
PMID:2203262 |
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NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543
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G
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Retn
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resistin
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multiple interactions decreases expression
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EXP ISO
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of RETN protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of RETN protein] Naproxen results in decreased expression of RETN protein
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CTD |
PMID:22150557 PMID:23784744 |
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NCBI chr12:6,508,653...6,511,115
Ensembl chr12:6,508,801...6,511,116
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G
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Retnlb
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resistin like beta
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of RETNLB protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of RETNLB protein]
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CTD |
PMID:22150557 |
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NCBI chr11:65,446,433...65,448,319
Ensembl chr11:65,446,434...65,448,319
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G
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RT1-DMb
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RT1 class II, locus DMb
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affects expression
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ISO
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Naproxen affects the expression of HLA-DMB mRNA
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CTD |
PMID:25811541 |
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NCBI chr20:4,695,009...4,702,560
Ensembl chr20:4,695,010...4,702,246
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G
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Sele
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selectin E
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELE protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of SELE protein]
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CTD |
PMID:22150557 |
|
NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903
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G
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Sell
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selectin L
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SELL protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of SELL protein]
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CTD |
PMID:22150557 |
|
NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600
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G
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Slc22a2
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solute carrier family 22 member 2
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decreases activity
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ISO
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Naproxen results in decreased activity of SLC22A2 protein
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CTD |
PMID:12388633 |
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NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
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G
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Slc22a25
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solute carrier family 22, member 25
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decreases activity
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ISO
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Naproxen results in decreased activity of SLC22A9 protein
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CTD |
PMID:12388633 |
|
NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:214,767,837...214,862,340
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G
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Slc22a6
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solute carrier family 22 member 6
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decreases activity
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ISO
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Naproxen results in decreased activity of SLC22A6 protein
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CTD |
PMID:12388633 |
|
NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311
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G
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Slc22a7
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solute carrier family 22 member 7
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decreases activity
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ISO
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Naproxen results in decreased activity of SLC22A7 protein
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CTD |
PMID:12388633 |
|
NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681
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G
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Slco1a1
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solute carrier organic anion transporter family, member 1a1
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multiple interactions decreases activity
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EXP
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Naproxen inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide] Naproxen results in decreased activity of SLCO1A1 protein
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CTD |
PMID:11883641 |
|
NCBI chr 4:176,606,924...176,682,027
Ensembl chr 4:176,607,687...176,681,992
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G
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Slco2a1
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solute carrier organic anion transporter family, member 2a1
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multiple interactions
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ISO
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Naproxen promotes the reaction [SLCO2A1 protein results in increased transport of Dinoprostone]
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CTD |
PMID:19843975 |
|
NCBI chr 8:112,467,739...112,551,923
Ensembl chr 8:112,467,160...112,551,921
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G
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Spp1
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secreted phosphoprotein 1
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of SPP1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of SPP1 protein]
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CTD |
PMID:22150557 |
|
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
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G
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Tal1
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TAL bHLH transcription factor 1, erythroid differentiation factor
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TAL1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TAL1 protein]
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CTD |
PMID:22150557 |
|
NCBI chr 5:133,823,093...133,837,737
Ensembl chr 5:133,826,003...133,837,738
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G
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Tek
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TEK receptor tyrosine kinase
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TEK protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TEK protein]
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CTD |
PMID:22150557 |
|
NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:114,723,006...114,849,991
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G
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Tgfb1
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transforming growth factor, beta 1
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TGFB1 protein]
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CTD |
PMID:22150557 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
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G
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Tgfb2
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transforming growth factor, beta 2
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TGFB2 protein]
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CTD |
PMID:22150557 |
|
NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856
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G
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Tgfb3
|
transforming growth factor, beta 3
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multiple interactions
|
EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TGFB3 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946
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G
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Timp1
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TIMP metallopeptidase inhibitor 1
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multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TIMP1 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135
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G
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Timp2
|
TIMP metallopeptidase inhibitor 2
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multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TIMP2 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214
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G
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Timp3
|
TIMP metallopeptidase inhibitor 3
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TIMP3 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547
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G
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Tlr4
|
toll-like receptor 4
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multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TLR4 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TLR4 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
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G
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Tnf
|
tumor necrosis factor
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multiple interactions
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ISO EXP
|
Naproxen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Naproxen inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Naproxen inhibits the reaction [TNF protein results in increased activity of RELA protein]; Naproxen inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Naproxen inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TNF protein]
|
CTD |
PMID:15489888 PMID:22150557 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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G
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Tnfrsf19
|
TNF receptor superfamily member 19
|
multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of TNFRSF19 protein]; Naproxen inhibits the reaction [Capsaicin affects the expression of TNFRSF19 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr15:39,268,305...39,334,566
Ensembl chr15:39,268,305...39,356,438
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G
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Tnfsf10
|
TNF superfamily member 10
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multiple interactions
|
EXP
|
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TNFSF10 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of TNFSF10 protein]
|
CTD |
PMID:22150557 |
|
NCBI chr 2:112,136,550...112,155,903
|
|
G
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Ugt1a1
|
UDP glucuronosyltransferase family 1 member A1
|
decreases activity increases glucuronidation
|
ISO
|
Naproxen results in decreased activity of UGT1A1 protein UGT1A1 protein results in increased glucuronidation of Naproxen
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CTD |
PMID:15593333 PMID:15843492 |
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NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
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G
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Ugt1a2
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UDP glucuronosyltransferase 1 family, polypeptide A2
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increases glucuronidation
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ISO
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UGT1A3 protein results in increased glucuronidation of Naproxen
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CTD |
PMID:15535975 PMID:15843492 |
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NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264
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G
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Ugt1a6
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UDP glucuronosyltransferase family 1 member A6
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increases glucuronidation
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ISO
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UGT1A6 protein results in increased glucuronidation of Naproxen
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CTD |
PMID:15843492 |
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NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264
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G
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Ugt1a9
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UDP glucuronosyltransferase family 1 member A9
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increases glucuronidation
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ISO
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UGT1A9 protein results in increased glucuronidation of Naproxen
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CTD |
PMID:15535975 |
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NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
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G
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Ugt2b1
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UDP glucuronosyltransferase 2 family, polypeptide B1
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increases glucuronidation
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EXP
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UGT2B1 protein results in increased glucuronidation of Naproxen
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CTD |
PMID:8302279 |
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NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331
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G
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Ugt2b7
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UDP glucuronosyltransferase family 2 member B7
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multiple interactions increases glucuronidation
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ISO
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Naproxen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Naproxen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] UGT2B7 protein alternative form results in increased glucuronidation of Naproxen; UGT2B7 protein results in increased glucuronidation of Naproxen
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CTD |
PMID:8423545 PMID:8517101 PMID:15535975 PMID:15843492 PMID:19740398 |
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NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451
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G
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Vcam1
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vascular cell adhesion molecule 1
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of VCAM1 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of VCAM1 protein]
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CTD |
PMID:22150557 |
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NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
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G
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Vegfa
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vascular endothelial growth factor A
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of VEGFA protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of VEGFA protein]
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CTD |
PMID:22150557 |
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NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
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G
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Zfp866
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zinc finger protein 866
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multiple interactions
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EXP
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[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CXCL5 protein]; Naproxen inhibits the reaction [Capsaicin results in increased expression of CXCL5 protein]
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CTD |
PMID:22150557 |
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NCBI chr16:19,687,869...19,710,407
Ensembl chr16:19,702,297...19,709,330
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