Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethionamide
go back to main search page
Accession:CHEBI:4885 term browser browse the term
Definition:A thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide.
Synonyms:exact_synonym: 2-ethylpyridine-4-carbothioamide
 related_synonym: 2-ethyl-4-thiopyridylamide;   ETH;   ETP;   Ethinamide;   Ethioniamide;   Ethylisothiamide;   Ethyonomide;   Etionamid;   Etionamide;   Etioniamid;   Formula=C8H10N2S;   InChI=1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11);   InChIKey=AEOCXXJPGCBFJA-UHFFFAOYSA-N;   SMILES=CCc1cc(ccn1)C(N)=S;   Trecator;   ethionamidum;   etionamida
 xref: Beilstein:116474;   CAS:536-33-4;   DrugBank:DB00609;   Drug_Central:1083;   HMDB:HMDB0014747;   KEGG:C07665;   KEGG:D00591;   LINCS:LSM-5620
 xref_mesh: MESH:D005000
 xref: PMID:14651620;   PMID:15673755;   PMID:15850780;   Patent:GB800250;   Reaxys:116474;   Wikipedia:Ethionamide



show annotations for term's descendants           Sort by:
 
ethionamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO Ethionamide results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Ethionamide results in increased expression of CCL2 mRNA; Ethionamide results in increased expression of CCL2 protein CTD PMID:25051504 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 affects expression EXP Ethionamide affects the expression of CCL5 protein CTD PMID:25051504 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression EXP Ethionamide results in decreased expression of CXCL10 protein CTD PMID:25051504 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases oxidation ISO FMO2 protein results in increased oxidation of Ethionamide CTD PMID:26062974 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO Ethionamide inhibits the reaction [arsenic trioxide results in increased expression of GCLM mRNA] CTD PMID:26708503 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Ethionamide inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA] CTD PMID:26708503 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il10 interleukin 10 decreases expression EXP Ethionamide results in decreased expression of IL10 protein CTD PMID:25051504 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B increases expression EXP Ethionamide results in increased expression of IL12B protein CTD PMID:25051504 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1a interleukin 1 alpha increases expression EXP Ethionamide results in increased expression of IL1A protein CTD PMID:25051504 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases expression
affects expression
EXP Ethionamide results in increased expression of IL1B mRNA
Ethionamide affects the expression of IL1B protein
CTD PMID:25051504 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression EXP Ethionamide results in decreased expression of IL6 protein CTD PMID:25051504 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO KEAP1 mRNA inhibits the reaction [Ethionamide results in increased susceptibility to arsenic trioxide] CTD PMID:26708503 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Lep leptin decreases expression EXP Ethionamide results in decreased expression of LEP protein CTD PMID:25051504 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 mRNA promotes the reaction [Ethionamide results in increased susceptibility to arsenic trioxide] CTD PMID:26708503 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Srxn1 sulfiredoxin 1 multiple interactions ISO Ethionamide inhibits the reaction [arsenic trioxide results in increased expression of SRXN1 mRNA] CTD PMID:26708503 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Ethionamide results in increased expression of TNF protein CTD PMID:25051504 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP Ethionamide results in increased expression of VEGFA protein CTD PMID:25051504 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        pro-agent 10115
          prodrug 9918
            ethionamide 18
              ethionamide S-oxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteromonocyclic compound 17120
                                    pyridines 9156
                                      ethionamide 18
                                        ethionamide S-oxide 0
paths to the root