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ONTOLOGY REPORT - ANNOTATIONS


Term:ethionamide
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Accession:CHEBI:4885 term browser browse the term
Definition:A thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide.
Synonyms:exact_synonym: 2-ethylpyridine-4-carbothioamide
 related_synonym: 2-ethyl-4-thiopyridylamide;   ETH;   ETP;   Ethinamide;   Ethioniamide;   Ethylisothiamide;   Ethyonomide;   Etionamid;   Etionamide;   Etioniamid;   Formula=C8H10N2S;   InChI=1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11);   InChIKey=AEOCXXJPGCBFJA-UHFFFAOYSA-N;   SMILES=CCc1cc(ccn1)C(N)=S;   Trecator;   ethionamidum;   etionamida
 xref: Beilstein:116474 "Beilstein";   CAS:536-33-4 "ChemIDplus";   CAS:536-33-4 "KEGG COMPOUND";   CAS:536-33-4 "NIST Chemistry WebBook";   DrugBank:DB00609;   Drug_Central:1083 "DrugCentral";   HMDB:HMDB0014747;   KEGG:C07665;   KEGG:D00591;   LINCS:LSM-5620
 xref_mesh: MESH:D005000
 xref: PMID:14651620 "Europe PMC";   PMID:15673755 "Europe PMC";   PMID:15850780 "Europe PMC";   Patent:GB800250;   Reaxys:116474 "Reaxys";   Wikipedia:Ethionamide


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ethionamide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6480464
G Fmo2 flavin containing dimethylaniline monoxygenase 2 JBrowse link 13 80,752,526 80,775,264 RGD:6480464
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Keap1 Kelch-like ECH-associated protein 1 JBrowse link 8 22,250,518 22,259,868 RGD:6480464
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Srxn1 sulfiredoxin 1 JBrowse link 3 147,608,850 147,614,410 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      application 19220
        pro-agent 8766
          prodrug 8563
            ethionamide 17
              ethionamide S-oxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic molecule 19327
                              organic cyclic compound 19076
                                organic heterocyclic compound 18151
                                  organic heteromonocyclic compound 16250
                                    pyridines 8319
                                      ethionamide 17
                                        ethionamide S-oxide 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.