|
G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein |
CTD |
PMID:29128272 |
|
NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
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G |
ACADL |
acyl-CoA dehydrogenase long chain |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACADL mRNA] |
CTD |
PMID:22464149 |
|
NCBI chr 2:210,187,923...210,225,447
Ensembl chr 2:210,187,126...210,225,447
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G |
ACE |
angiotensin I converting enzyme |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE] Thioctic Acid affects the reaction [Dietary Fats affects the activity of ACE protein]; Thioctic Acid affects the reaction [Dietary Fats affects the expression of ACE mRNA] |
CTD |
PMID:26518973 PMID:27260466 |
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NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
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G |
ACHE |
acetylcholinesterase (Yt blood group) |
multiple interactions |
ISO |
[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein] [Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of ACHE protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein] |
CTD |
PMID:19669875 PMID:20663516 PMID:20730314 PMID:32911022 |
|
NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
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G |
ACOX1 |
acyl-CoA oxidase 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] |
CTD |
PMID:22464149 |
|
NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177
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G |
ACTA2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Mitogens results in increased expression of ACTA2 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of ACTA2 protein] |
CTD |
PMID:21251946 PMID:24704557 PMID:29760339 PMID:34252510 PMID:35187969 |
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NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339
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G |
ADA |
adenosine deaminase |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Valproic Acid] results in decreased activity of ADA protein |
CTD |
PMID:32662911 |
|
NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252
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G |
ADIPOQ |
adiponectin, C1Q and collagen domain containing |
multiple interactions increases expression |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] Thioctic Acid results in increased expression of ADIPOQ mRNA; Thioctic Acid results in increased expression of ADIPOQ protein |
CTD |
PMID:22664981 |
|
NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
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|
G |
AGT |
angiotensinogen |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Dietary Fats] results in decreased expression of AGT mRNA |
CTD |
PMID:27260466 |
|
NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
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|
G |
AGTR1 |
angiotensin II receptor type 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of AGTR1] Thioctic Acid affects the reaction [Dietary Fats affects the expression of AGTR1A mRNA] |
CTD |
PMID:26518973 PMID:27260466 |
|
NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
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G |
AKT1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
Thioctic Acid results in decreased phosphorylation of AKT1 protein Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of AKT1 mRNA] |
CTD |
PMID:21351249 PMID:27260466 |
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NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
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G |
ALAD |
aminolevulinate dehydratase |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [gallium arsenide results in decreased activity of ALAD protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] |
CTD |
PMID:19798568 PMID:20026167 PMID:20584200 PMID:21783994 |
|
NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290
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G |
ALB |
albumin |
multiple interactions |
ISO EXP |
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ALB protein] ALB protein results in increased uptake of [Thioctic Acid binds to Gold] |
CTD |
PMID:24704557 PMID:28433809 |
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NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
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G |
APLN |
apelin |
multiple interactions increases secretion increases expression |
ISO |
acadesine inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA]; acadesine inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] |
CTD |
PMID:21461750 |
|
NCBI chr X:129,645,259...129,654,956
Ensembl chr X:129,645,259...129,654,956
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G |
ATF4 |
activating transcription factor 4 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein] Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein] |
CTD |
PMID:23892647 PMID:30605698 |
|
NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,683
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G |
ATF6 |
activating transcription factor 6 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF6 mRNA] |
CTD |
PMID:23892647 |
|
NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574
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G |
ATP1A2 |
ATPase Na+/K+ transporting subunit alpha 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Silicon results in decreased expression of ATP1A2 mRNA] |
CTD |
PMID:34252510 |
|
NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591
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G |
ATP1B1 |
ATPase Na+/K+ transporting subunit beta 1 |
multiple interactions |
ISO |
Thioctic Acid affects the reaction [Dietary Fats affects the expression of ATP1B1 mRNA] |
CTD |
PMID:27260466 |
|
NCBI chr 1:169,106,690...169,132,719
Ensembl chr 1:169,105,697...169,310,992
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G |
ATP2A2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
multiple interactions |
ISO |
Thioctic Acid promotes the reaction [Dietary Fats results in decreased expression of ATP2A2 mRNA] |
CTD |
PMID:27260466 |
|
NCBI chr12:110,280,616...110,351,093
Ensembl chr12:110,280,756...110,351,093
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G |
BAX |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased localization of BAX protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of BAX protein] Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BAX mRNA] [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of BAX mRNA; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX protein] |
CTD |
PMID:15735709 PMID:23830814 PMID:23892647 PMID:27544635 PMID:30605698 PMID:32061141 PMID:34133789 More...
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|
NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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G |
BBC3 |
BCL2 binding component 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BBC3 mRNA] |
CTD |
PMID:23892647 |
|
NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766
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G |
BCHE |
butyrylcholinesterase |
multiple interactions |
ISO |
[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein] Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of BCHE protein] |
CTD |
PMID:20663516 PMID:32911022 |
|
NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
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G |
BCL2 |
BCL2 apoptosis regulator |
multiple interactions decreases response to substance |
EXP ISO |
Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in decreased expression of BCL2 protein]; Thioctic Acid results in increased degradation of and results in decreased expression of BCL2 protein Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA] Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 protein] BCL2 protein results in decreased susceptibility to Thioctic Acid |
CTD |
PMID:16990509 PMID:21600978 PMID:23830814 PMID:27260466 PMID:27544635 PMID:30605698 PMID:32061141 PMID:34133789 More...
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NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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G |
BCL2L1 |
BCL2 like 1 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of BCL2L1 mRNA |
CTD |
PMID:23830814 |
|
NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
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G |
BRCA2 |
BRCA2 DNA repair associated |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of BRCA2 mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr13:32,315,508...32,400,268
Ensembl chr13:32,315,086...32,400,268
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G |
C1QA |
complement C1q A chain |
decreases expression |
ISO |
Thioctic Acid results in decreased expression of C1QA mRNA |
CTD |
PMID:19555370 |
|
NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,635,077...22,639,678
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G |
C4B |
complement C4B (Chido/Rodgers blood group) |
decreases expression |
ISO |
Thioctic Acid results in decreased expression of C4B mRNA |
CTD |
PMID:19555370 |
|
NCBI chr 6:32,014,795...32,035,418
Ensembl chr 6:32,014,795...32,035,418
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G |
CALB2 |
calbindin 2 |
multiple interactions |
ISO |
Thioctic Acid affects the reaction [Propylthiouracil results in increased expression of CALB2 mRNA] |
CTD |
PMID:31068541 |
|
NCBI chr16:71,358,723...71,390,433
Ensembl chr16:71,358,713...71,390,436
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G |
CALM1 |
calmodulin 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of CALM1 mRNA] |
CTD |
PMID:26165643 |
|
NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268
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G |
CAMK2A |
calcium/calmodulin dependent protein kinase II alpha |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of CAMK2A protein] |
CTD |
PMID:37739047 |
|
NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093
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G |
CASP3 |
caspase 3 |
multiple interactions increases expression increases activity |
ISO EXP |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein] Thioctic Acid results in increased expression of CASP3 protein modified form Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein] Thioctic Acid results in increased activity of CASP3 protein [Ryanodine co-treated with Thioctic Acid] results in decreased activity of CASP3 protein; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP3 protein modified form]; Thioctic Acid inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein] |
CTD |
PMID:15909127 PMID:17079870 PMID:19951573 PMID:21062633 PMID:21763304 PMID:23892647 PMID:27544635 PMID:29214690 PMID:30605698 PMID:32061141 PMID:34133789 More...
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CASP8 |
caspase 8 |
multiple interactions |
ISO EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein] |
CTD |
PMID:23830814 PMID:27544635 |
|
NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
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G |
CASP9 |
caspase 9 |
increases activity multiple interactions |
EXP ISO |
Thioctic Acid results in increased activity of CASP9 protein Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein] [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CASP9 mRNA; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP9 protein modified form]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP9 protein] |
CTD |
PMID:16990509 PMID:19951573 PMID:23830814 PMID:27544635 PMID:30605698 |
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NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
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G |
CAT |
catalase |
multiple interactions increases expression increases activity |
ISO EXP |
Thioctic Acid inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of CAT mRNA] Thioctic Acid results in increased expression of CAT mRNA [Paraquat co-treated with Thioctic Acid] results in increased expression of CAT mRNA Thioctic Acid results in increased activity of CAT protein [acetovanillone results in increased susceptibility to Thioctic Acid] inhibits the reaction [Mitogens results in decreased activity of CAT protein]; Succimer promotes the reaction [Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Valproic Acid results in decreased activity of CAT protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]]; Thioctic Acid promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]] |
CTD |
PMID:15998567 PMID:19368863 PMID:19699728 PMID:19715735 PMID:21763304 PMID:22623521 PMID:23649336 PMID:26276312 PMID:27260466 PMID:27581792 PMID:28880400 PMID:29214690 PMID:29760339 PMID:32662911 PMID:34252510 More...
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NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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G |
CCL2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of CCL2 mRNA] |
CTD |
PMID:22488045 |
|
NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
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G |
CCND1 |
cyclin D1 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein] |
CTD |
PMID:21600978 |
|
NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
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G |
CD36 |
CD36 molecule (CD36 blood group) |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]] |
CTD |
PMID:21315065 |
|
NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277
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G |
CD86 |
CD86 molecule |
increases expression |
EXP |
Thioctic Acid results in increased expression of CD86 protein |
CTD |
PMID:19033392 |
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NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
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G |
CD8A |
CD8 subunit alpha |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA |
CTD |
PMID:23830814 |
|
NCBI chr 2:86,784,605...86,808,396
Ensembl chr 2:86,784,610...86,808,396
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G |
CDX4 |
caudal type homeobox 4 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of CDX4 mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr X:73,447,053...73,455,171
Ensembl chr X:73,447,053...73,455,171
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G |
CHAT |
choline O-acetyltransferase |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein |
CTD |
PMID:19669875 |
|
NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942
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G |
CNTF |
ciliary neurotrophic factor |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone results in decreased activity of CNTF protein] |
CTD |
PMID:19635391 |
|
NCBI chr11:58,622,665...58,625,733
Ensembl chr11:58,622,665...58,625,733
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G |
COL1A1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of COL1A1 mRNA; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA] Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL1A1 mRNA] |
CTD |
PMID:21251946 PMID:23830814 PMID:34252510 PMID:35187969 |
|
NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
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G |
COL3A1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL3A1 mRNA] |
CTD |
PMID:34252510 |
|
NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
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G |
COX4I1 |
cytochrome c oxidase subunit 4I1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Silicon results in decreased expression of COX4I1 mRNA] |
CTD |
PMID:34252510 |
|
NCBI chr16:85,799,695...85,807,068
Ensembl chr16:85,798,633...85,807,068
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G |
CPT1A |
carnitine palmitoyltransferase 1A |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] |
CTD |
PMID:22464149 |
|
NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410
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G |
CREB1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:32061141 |
|
NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988
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G |
CRP |
C-reactive protein |
multiple interactions |
ISO |
Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein] |
CTD |
PMID:26276312 |
|
NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
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G |
CRYAA |
crystallin alpha A |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [naphthalene results in increased cleavage of CRYAA protein] |
CTD |
PMID:20597648 |
|
NCBI chr21:43,169,008...43,172,810
Ensembl chr21:43,169,008...43,172,805
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G |
CTNNB1 |
catenin beta 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of CTNNB1 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of CTNNB1 protein] |
CTD |
PMID:34133789 |
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NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
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G |
CTSD |
cathepsin D |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] |
CTD |
PMID:12841641 |
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NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573
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G |
CTSS |
cathepsin S |
decreases expression |
ISO |
Thioctic Acid results in decreased expression of CTSS mRNA |
CTD |
PMID:19555370 |
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NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,079...150,765,957
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G |
CXCL8 |
C-X-C motif chemokine ligand 8 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of CXCL8 mRNA] |
CTD |
PMID:30758914 |
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NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
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G |
CYBA |
cytochrome b-245 alpha chain |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of CYBA mRNA] |
CTD |
PMID:35187969 |
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NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083
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G |
CYBB |
cytochrome b-245 beta chain |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB] |
CTD |
PMID:26518973 |
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NCBI chr X:37,780,059...37,813,461
Ensembl chr X:37,780,018...37,813,461
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G |
CYCS |
cytochrome c, somatic |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Streptozocin affects the localization of CYCS protein] |
CTD |
PMID:19951573 |
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NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
multiple interactions |
ISO |
[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] |
CTD |
PMID:21932800 |
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NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
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G |
CYP1A2 |
cytochrome P450 family 1 subfamily A member 2 |
multiple interactions |
ISO EXP |
[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:21932800 PMID:24120545 |
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NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
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G |
CYP2C19 |
cytochrome P450 family 2 subfamily C member 19 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:24120545 |
|
NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
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G |
CYP2C8 |
cytochrome P450 family 2 subfamily C member 8 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:24120545 |
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NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
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G |
CYP2C9 |
cytochrome P450 family 2 subfamily C member 9 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:24120545 |
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NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
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G |
CYP2D6 |
cytochrome P450 family 2 subfamily D member 6 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:24120545 |
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NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
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G |
CYP2E1 |
cytochrome P450 family 2 subfamily E member 1 |
multiple interactions |
ISO |
Thioctic Acid affects the reaction [cyanoginosin LR affects the expression of CYP2E1 protein] |
CTD |
PMID:32061150 |
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NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:24120545 |
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NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
DAB1 |
DAB adaptor protein 1 |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of DAB1 mRNA |
CTD |
PMID:31068541 |
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NCBI chr 1:56,994,778...58,546,726
Ensembl chr 1:56,994,778...58,546,734
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G |
DDIT3 |
DNA damage inducible transcript 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of DDIT3 protein] Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein] |
CTD |
PMID:23892647 PMID:30605698 |
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NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
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G |
DGAT2 |
diacylglycerol O-acyltransferase 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of DGAT2 mRNA] |
CTD |
PMID:22464149 |
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NCBI chr11:75,768,778...75,801,534
Ensembl chr11:75,759,512...75,801,535
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G |
DIO1 |
iodothyronine deiodinase 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of DIO1 mRNA] |
CTD |
PMID:27260466 |
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NCBI chr 1:53,894,187...53,911,086
Ensembl chr 1:53,891,239...53,911,086
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G |
DLD |
dihydrolipoamide dehydrogenase |
multiple interactions |
ISO |
[5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid] |
CTD |
PMID:21551353 |
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NCBI chr 7:107,891,107...107,921,198
Ensembl chr 7:107,891,162...107,931,730
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G |
DLG4 |
discs large MAGUK scaffold protein 4 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of DLG4 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of DLG4 protein] |
CTD |
PMID:34133789 |
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NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,841
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G |
DNM1L |
dynamin 1 like |
multiple interactions decreases expression |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L mRNA]; Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L protein] Thioctic Acid results in decreased expression of DNM1L mRNA |
CTD |
PMID:37739047 |
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NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650
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G |
DRD2 |
dopamine receptor D2 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]; Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein] |
CTD |
PMID:20730801 |
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NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
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G |
EIF2A |
eukaryotic translation initiation factor 2A |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2A protein] |
CTD |
PMID:23892647 |
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NCBI chr 3:150,546,787...150,586,016
Ensembl chr 3:150,546,678...150,586,016
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G |
EIF2S1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form] |
CTD |
PMID:30605698 |
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NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516
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G |
FAS |
Fas cell surface death receptor |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein] |
CTD |
PMID:27544635 |
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NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
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G |
FIS1 |
fission, mitochondrial 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of FIS1 mRNA] |
CTD |
PMID:37739047 |
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NCBI chr 7:101,239,472...101,245,081
Ensembl chr 7:101,239,458...101,252,316
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G |
FLT1 |
fms related receptor tyrosine kinase 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA] |
CTD |
PMID:23608068 |
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NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145
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G |
FN1 |
fibronectin 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Diazinon results in decreased expression of FN1 protein] Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA] |
CTD |
PMID:32911022 PMID:35187969 |
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NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073
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G |
FOS |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of FOS mRNA |
CTD |
PMID:31068541 |
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NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
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G |
FOXO3 |
forkhead box O3 |
decreases acetylation multiple interactions |
ISO |
Thioctic Acid results in decreased acetylation of FOXO3 protein [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein |
CTD |
PMID:22327056 |
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NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
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G |
FRAS1 |
Fraser extracellular matrix complex subunit 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FRAS1 mRNA] |
CTD |
PMID:23608068 |
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NCBI chr 4:78,057,323...78,544,269
Ensembl chr 4:78,057,323...78,544,269
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G |
FSHB |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of FSHB protein] |
CTD |
PMID:20957662 |
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NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261
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G |
FZD2 |
frizzled class receptor 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of FZD2 protein] |
CTD |
PMID:34133789 |
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NCBI chr17:44,557,484...44,561,262
Ensembl chr17:44,557,484...44,561,262
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G |
GAD1 |
glutamate decarboxylase 1 |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GAD1 mRNA |
CTD |
PMID:31068541 |
|
NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151
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G |
GCLC |
glutamate-cysteine ligase catalytic subunit |
increases expression multiple interactions |
EXP ISO |
Thioctic Acid results in increased expression of GCLC mRNA Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA]; Thioctic Acid results in increased expression of and results in increased activity of GCLC protein Thioctic Acid inhibits the reaction [Silicon results in decreased expression of GCLC protein] Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein] |
CTD |
PMID:16249512 PMID:17940886 PMID:26365678 PMID:27298056 PMID:32061141 PMID:34252510 More...
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NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
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G |
GCLM |
glutamate-cysteine ligase modifier subunit |
increases expression multiple interactions |
EXP ISO |
Thioctic Acid results in increased expression of GCLM mRNA; Thioctic Acid results in increased expression of GCLM protein Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM mRNA]; Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM protein] Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM protein] |
CTD |
PMID:16249512 PMID:26365678 PMID:32061141 |
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NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456
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G |
GFAP |
glial fibrillary acidic protein |
decreases expression |
ISO |
Thioctic Acid results in decreased expression of GFAP mRNA |
CTD |
PMID:19555370 |
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NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
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G |
GGT1 |
gamma-glutamyltransferase 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein] |
CTD |
PMID:24704557 |
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NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,594,811...24,629,005
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G |
GJA1 |
gap junction protein alpha 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Cadmium affects the localization of GJA1 protein]; Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of GJA1 mRNA] Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA] |
CTD |
PMID:26165643 PMID:27260466 |
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NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
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G |
GLS |
glutaminase |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GLS protein] |
CTD |
PMID:32061141 |
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NCBI chr 2:190,880,821...190,965,552
Ensembl chr 2:190,880,821...190,965,552
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G |
GNRHR |
gonadotropin releasing hormone receptor |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GNRHR mRNA] |
CTD |
PMID:28070105 |
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NCBI chr 4:67,737,118...67,754,388
Ensembl chr 4:67,737,118...67,754,388
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G |
GPT |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GPT protein] Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of GPT protein] |
CTD |
PMID:24704557 PMID:37739047 |
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NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
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G |
GPX1 |
glutathione peroxidase 1 |
increases expression multiple interactions |
EXP ISO |
Thioctic Acid results in increased expression of GPX1 mRNA Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GPX1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GPX1 mRNA] |
CTD |
PMID:23649336 PMID:32061141 |
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NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
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G |
GPX2 |
glutathione peroxidase 2 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GPX2 mRNA |
CTD |
PMID:23830814 |
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NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746
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G |
GPX3 |
glutathione peroxidase 3 |
increases expression multiple interactions |
EXP |
Thioctic Acid results in increased expression of GPX3 mRNA [Paraquat co-treated with Thioctic Acid] results in increased expression of GPX3 mRNA |
CTD |
PMID:23649336 |
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NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988
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G |
GPX5 |
glutathione peroxidase 5 |
increases expression |
EXP |
Thioctic Acid results in increased expression of GPX5 mRNA |
CTD |
PMID:23649336 |
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NCBI chr 6:28,525,881...28,534,955
Ensembl chr 6:28,525,881...28,534,955
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G |
GRIN1 |
glutamate ionotropic receptor NMDA type subunit 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 protein] |
CTD |
PMID:32061141 |
|
NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756
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G |
GRIN2A |
glutamate ionotropic receptor NMDA type subunit 2A |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GRIN2A mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A protein] |
CTD |
PMID:31068541 PMID:32061141 |
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NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928
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G |
GSK3B |
glycogen synthase kinase 3 beta |
increases phosphorylation multiple interactions |
ISO |
Thioctic Acid results in increased phosphorylation of GSK3B protein Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of GSK3B protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of GSK3B protein] Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA] |
CTD |
PMID:19879292 PMID:27260466 PMID:34133789 |
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NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
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G |
GSR |
glutathione-disulfide reductase |
multiple interactions increases expression |
ISO EXP |
Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of GSR protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GSR protein] Thioctic Acid inhibits the reaction [cyanoginosin LR results in decreased activity of GSR protein] Thioctic Acid results in increased expression of GSR mRNA |
CTD |
PMID:19699728 PMID:22623521 PMID:23649336 PMID:27581792 PMID:32061150 |
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NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
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G |
GSS |
glutathione synthetase |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of GSS protein] |
CTD |
PMID:32061141 |
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NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027
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G |
GSTM1 |
glutathione S-transferase mu 1 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA [Dietary Fats co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA |
CTD |
PMID:18367378 PMID:23830814 |
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NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
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G |
GSTP1 |
glutathione S-transferase pi 1 |
multiple interactions increases expression |
ISO |
[Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; Thioctic Acid results in increased expression of and results in increased activity of GSTP1 protein Thioctic Acid results in increased expression of GSTP1 mRNA |
CTD |
PMID:20237067 |
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NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
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G |
GUSB |
glucuronidase beta |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GUSB protein] |
CTD |
PMID:19699728 |
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NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215
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G |
HAVCR1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
EXP |
[Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein |
CTD |
PMID:28433809 |
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NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396
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G |
HMOX1 |
heme oxygenase 1 |
multiple interactions increases expression |
EXP ISO |
[Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of HMOX1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein] Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 protein] Thioctic Acid results in increased expression of HMOX1 mRNA; Thioctic Acid results in increased expression of HMOX1 protein Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of HMOX1 mRNA] |
CTD |
PMID:19033392 PMID:21315065 PMID:22488045 PMID:23649336 PMID:23942037 PMID:24361488 PMID:27260466 PMID:27298056 PMID:30758914 PMID:31319135 PMID:32061141 More...
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NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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G |
HS1BP3 |
HCLS1 binding protein 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of HS1BP3 mRNA] |
CTD |
PMID:23608068 |
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NCBI chr 2:20,553,861...20,651,098
Ensembl chr 2:20,560,448...20,651,130
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G |
HSPA1A |
heat shock protein family A (Hsp70) member 1A |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA] |
CTD |
PMID:28880400 |
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NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
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G |
HSPA5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HSPA5 protein] Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein] |
CTD |
PMID:23892647 PMID:30605698 |
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NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
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G |
IGFBP3 |
insulin like growth factor binding protein 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA] |
CTD |
PMID:28880400 |
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NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874
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G |
IL10 |
interleukin 10 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of IL10]; Thioctic Acid promotes the reaction [Carrageenan results in increased expression of IL10 mRNA] |
CTD |
PMID:19735303 PMID:26518973 |
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NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
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G |
IL1A |
interleukin 1 alpha |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of IL1A mRNA |
CTD |
PMID:31068541 |
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NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
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G |
IL1B |
interleukin 1 beta |
multiple interactions |
ISO EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL1B mRNA; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL1B] Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] |
CTD |
PMID:23830814 PMID:24975507 PMID:26518973 |
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NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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G |
IL2 |
interleukin 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL2 protein] |
CTD |
PMID:21195065 |
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NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
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G |
IL22RA2 |
interleukin 22 receptor subunit alpha 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of IL22RA2 mRNA] |
CTD |
PMID:23608068 |
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NCBI chr 6:137,143,820...137,173,644
Ensembl chr 6:137,143,820...137,173,648
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G |
IL4 |
interleukin 4 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL4 mRNA |
CTD |
PMID:23830814 |
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NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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G |
IL6 |
interleukin 6 |
multiple interactions |
ISO EXP |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of IL6 mRNA] [Thioctic Acid binds to Gold] which results in increased expression of IL6 protein acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL6]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]] |
CTD |
PMID:22488045 PMID:26518973 PMID:28433809 PMID:29233029 PMID:29760339 |
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NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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G |
INS |
insulin |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein] |
CTD |
PMID:16505238 |
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NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
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G |
INS-IGF2 |
INS-IGF2 readthrough |
multiple interactions |
ISO |
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased secretion of INS1 protein]] |
CTD |
PMID:21461750 PMID:29760339 |
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NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
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G |
IRF1 |
interferon regulatory factor 1 |
multiple interactions |
EXP |
Thioctic Acid results in increased sumoylation of and results in decreased activity of IRF1 protein |
CTD |
PMID:24975507 |
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NCBI chr 5:132,481,609...132,490,773
Ensembl chr 5:132,440,440...132,508,719
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression increases activity |
ISO |
[Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer] Thioctic Acid results in increased expression of JUN protein Thioctic Acid results in increased activity of JUN protein |
CTD |
PMID:20237067 |
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NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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G |
KEAP1 |
kelch like ECH associated protein 1 |
increases expression multiple interactions |
EXP ISO |
Thioctic Acid results in increased expression of KEAP1 protein Thioctic Acid inhibits the reaction [Silicon results in increased expression of KEAP1 protein] |
CTD |
PMID:19033392 PMID:34252510 |
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NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
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G |
LDHC |
lactate dehydrogenase C |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of LDHC protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased expression of LDHC protein] |
CTD |
PMID:21195065 PMID:27581792 |
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NCBI chr11:18,412,318...18,452,063
Ensembl chr11:18,412,318...18,452,063
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G |
LEP |
leptin |
decreases secretion decreases expression |
ISO |
Thioctic Acid results in decreased secretion of LEP protein Thioctic Acid results in decreased expression of LEP mRNA; Thioctic Acid results in decreased expression of LEP protein |
CTD |
PMID:21351249 |
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NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629
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G |
LHB |
luteinizing hormone subunit beta |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of LHB protein]; Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LHB mRNA] |
CTD |
PMID:20957662 PMID:28070105 |
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NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091
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G |
LIPE |
lipase E, hormone sensitive type |
multiple interactions increases phosphorylation |
ISO |
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Thioctic Acid results in increased phosphorylation of LIPE protein] |
CTD |
PMID:22941773 |
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NCBI chr19:42,401,514...42,427,388
Ensembl chr19:42,401,514...42,427,388
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
affects activity multiple interactions |
ISO |
Thioctic Acid affects the activity of MAPK1 protein Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK1 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK1 protein] |
CTD |
PMID:15909127 PMID:21251946 PMID:32061141 |
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NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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G |
MAPK14 |
mitogen-activated protein kinase 14 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK14 mRNA |
CTD |
PMID:23830814 |
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NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK3 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK3 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK3 protein] |
CTD |
PMID:21251946 PMID:23830814 PMID:32061141 |
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NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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G |
MAPK8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK8 mRNA |
CTD |
PMID:23830814 |
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NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
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G |
MAPT |
microtubule associated protein tau |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of MAPT protein] |
CTD |
PMID:34133789 |
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NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334
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G |
MFF |
mitochondrial fission factor |
multiple interactions decreases expression |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFF mRNA] Thioctic Acid results in decreased expression of MFF mRNA |
CTD |
PMID:37739047 |
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NCBI chr 2:227,325,251...227,357,836
Ensembl chr 2:227,325,151...227,357,833
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G |
MFN2 |
mitofusin 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFN2 mRNA] |
CTD |
PMID:37739047 |
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NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211
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G |
MIR21 |
microRNA 21 |
multiple interactions |
ISO |
Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA] |
CTD |
PMID:26276312 |
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NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
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G |
MIR210 |
microRNA 210 |
multiple interactions |
ISO |
[Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]] |
CTD |
PMID:26276312 |
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NCBI chr11:568,089...568,198
Ensembl chr11:568,089...568,198
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G |
MMP12 |
matrix metallopeptidase 12 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA |
CTD |
PMID:23830814 |
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NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982
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G |
MMP13 |
matrix metallopeptidase 13 |
multiple interactions |
EXP ISO |
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein] Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA] |
CTD |
PMID:24975507 PMID:29233029 |
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NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
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G |
MMP2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of MMP2 mRNA |
CTD |
PMID:23830814 |
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NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
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G |
MMP3 |
matrix metallopeptidase 3 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] |
CTD |
PMID:24975507 |
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NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
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G |
MSR1 |
macrophage scavenger receptor 1 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]] |
CTD |
PMID:21315065 |
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NCBI chr 8:16,107,881...16,192,651
Ensembl chr 8:16,107,878...16,567,490
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G |
MT1X |
metallothionein 1X |
multiple interactions |
ISO |
[Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MT1 mRNA |
CTD |
PMID:18367378 |
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NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
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G |
MVD |
mevalonate diphosphate decarboxylase |
multiple interactions |
ISO |
[Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MVD mRNA |
CTD |
PMID:18367378 |
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NCBI chr16:88,651,940...88,663,091
Ensembl chr16:88,651,935...88,663,161
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G |
MYC |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of MYC protein] |
CTD |
PMID:21600978 |
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NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
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G |
NCF1 |
neutrophil cytosolic factor 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of NCF1] |
CTD |
PMID:26518973 |
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NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315
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G |
NFE2L2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions affects localization increases expression increases activity decreases expression |
EXP ISO |
[Paraquat co-treated with Thioctic Acid] results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NFE2L2 mRNA]; Thioctic Acid promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thioctic Acid results in increased expression of and affects the localization of NFE2L2 protein Thioctic Acid affects the localization of NFE2L2 protein Thioctic Acid results in increased expression of NFE2L2 mRNA; Thioctic Acid results in increased expression of NFE2L2 protein Thioctic Acid results in increased activity of NFE2L2 protein [Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer] Thioctic Acid results in decreased expression of NFE2L2 mRNA; Thioctic Acid results in decreased expression of NFE2L2 protein [Thioctic Acid co-treated with cyanoginosin LR] results in increased expression of NFE2L2 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of NFE2L2 protein] |
CTD |
PMID:17197552 PMID:18258206 PMID:20237067 PMID:22488045 PMID:23649336 PMID:24361488 PMID:27260466 PMID:27298056 PMID:30758914 PMID:31319135 PMID:32061141 PMID:32061150 PMID:34252510 PMID:36880193 More...
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NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
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G |
NFKB1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
EXP ISO |
Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein] [Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA |
CTD |
PMID:21600978 PMID:31068541 |
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NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
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G |
NFKBIA |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of NFKBIA protein] |
CTD |
PMID:34133789 |
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NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
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G |
NGFR |
nerve growth factor receptor |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TNFRSF10B mRNA] |
CTD |
PMID:23608068 |
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NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008
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G |
NOS2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of NOS2]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA] |
CTD |
PMID:15453632 PMID:21763304 PMID:29233029 |
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NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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G |
NOS3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] |
CTD |
PMID:27260466 |
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NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
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G |
NOX1 |
NADPH oxidase 1 |
multiple interactions |
ISO |
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]] |
CTD |
PMID:29760339 |
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NCBI chr X:100,843,324...100,874,359
Ensembl chr X:100,843,324...100,874,359
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G |
NOX4 |
NADPH oxidase 4 |
multiple interactions |
ISO |
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]] Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA] |
CTD |
PMID:29760339 PMID:35187969 |
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NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
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G |
NQO1 |
NAD(P)H quinone dehydrogenase 1 |
increases activity increases expression multiple interactions |
EXP ISO |
Thioctic Acid results in increased activity of NQO1 protein Thioctic Acid results in increased expression of NQO1 mRNA; Thioctic Acid results in increased expression of NQO1 protein [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 protein] [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA] |
CTD |
PMID:12180195 PMID:17940886 PMID:19033392 PMID:23649336 PMID:23830814 PMID:30758914 PMID:31068541 PMID:31319135 More...
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NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
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G |
OPA1 |
OPA1 mitochondrial dynamin like GTPase |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of OPA1 mRNA] |
CTD |
PMID:37739047 |
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NCBI chr 3:193,593,208...193,697,811
Ensembl chr 3:193,593,144...193,697,811
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G |
OTX2 |
orthodenticle homeobox 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA] |
CTD |
PMID:31068541 |
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NCBI chr14:56,799,905...56,810,479
Ensembl chr14:56,799,905...56,816,693
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G |
PAH |
phenylalanine hydroxylase |
decreases expression |
ISO |
Thioctic Acid results in decreased expression of PAH mRNA |
CTD |
PMID:19555370 |
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NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
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G |
PCDHB6 |
protocadherin beta 6 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of PCDHB6 mRNA] |
CTD |
PMID:23608068 |
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NCBI chr 5:141,150,057...141,153,287
Ensembl chr 5:141,150,057...141,153,287
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G |
PCNA |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of PCNA protein] |
CTD |
PMID:21251946 |
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NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
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G |
PINK1 |
PTEN induced kinase 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PINK1 mRNA] |
CTD |
PMID:37739047 |
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NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511
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G |
PLAAT3 |
phospholipase A and acyltransferase 3 |
decreases activity decreases expression |
ISO |
Thioctic Acid results in decreased activity of PLAAT3 protein Thioctic Acid results in decreased expression of PLAAT3 mRNA |
CTD |
PMID:22941773 |
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NCBI chr11:63,574,462...63,616,927
Ensembl chr11:63,573,195...63,616,883
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G |
PLIN1 |
perilipin 1 |
increases phosphorylation |
ISO |
Thioctic Acid results in increased phosphorylation of PLIN1 protein |
CTD |
PMID:22941773 |
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NCBI chr15:89,664,367...89,679,367
Ensembl chr15:89,664,367...89,679,427
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G |
POR |
cytochrome p450 oxidoreductase |
multiple interactions decreases activity |
ISO EXP |
[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; [Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:16391466 PMID:21932800 PMID:24120545 |
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NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
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G |
PPARA |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA] |
CTD |
PMID:22464149 |
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NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755
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G |
PPARG |
peroxisome proliferator activated receptor gamma |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Dietary Fats] results in increased expression of PPARG mRNA |
CTD |
PMID:22464149 |
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NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
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G |
PPARGC1A |
PPARG coactivator 1 alpha |
multiple interactions decreases expression increases expression |
EXP ISO |
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein Thioctic Acid results in decreased expression of PPARGC1A protein [Thioctic Acid co-treated with Silicon] results in increased expression of PPARGC1A protein; Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of PPARGC1A mRNA] Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA] Thioctic Acid results in increased expression of PPARGC1A protein |
CTD |
PMID:20414966 PMID:22464149 PMID:34252510 PMID:37739047 |
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NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
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G |
PPARGC1B |
PPARG coactivator 1 beta |
multiple interactions decreases acetylation |
ISO |
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA] Thioctic Acid results in decreased acetylation of PPARGC1B protein |
CTD |
PMID:22327056 PMID:22464149 |
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NCBI chr 5:149,730,310...149,857,959
Ensembl chr 5:149,730,298...149,855,022
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G |
PRDX3 |
peroxiredoxin 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRDX3 mRNA] |
CTD |
PMID:37739047 |
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NCBI chr10:119,167,720...119,178,812
Ensembl chr10:119,167,720...119,178,812
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G |
PRKAA2 |
protein kinase AMP-activated catalytic subunit alpha 2 |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Silicon] results in increased expression of PRKAA2 mRNA |
CTD |
PMID:34252510 |
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NCBI chr 1:56,645,314...56,715,335
Ensembl chr 1:56,645,314...56,715,335
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G |
PRKN |
parkin RBR E3 ubiquitin protein ligase |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRKN mRNA] |
CTD |
PMID:37739047 |
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NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775
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G |
PSEN1 |
presenilin 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of PSEN1 protein] |
CTD |
PMID:34133789 |
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NCBI chr14:73,136,417...73,223,691
Ensembl chr14:73,136,418...73,223,691
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]]; Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]] |
CTD |
PMID:19735303 PMID:23830814 PMID:26276312 |
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NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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G |
RELA |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases phosphorylation |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of RELA protein] Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of RELA protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA mRNA] Thioctic Acid results in decreased phosphorylation of RELA protein |
CTD |
PMID:22488045 PMID:29233029 PMID:34133789 |
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NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
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G |
RELN |
reelin |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of RELN mRNA |
CTD |
PMID:31068541 |
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NCBI chr 7:103,471,789...103,989,658
Ensembl chr 7:103,471,381...103,989,658
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G |
S100B |
S100 calcium binding protein B |
multiple interactions |
ISO |
[Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein] |
CTD |
PMID:23880158 |
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NCBI chr21:46,598,604...46,605,082
Ensembl chr21:46,598,604...46,605,208
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G |
SEMA5A |
semaphorin 5A |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of SEMA5A mRNA] |
CTD |
PMID:23608068 |
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NCBI chr 5:9,035,033...9,546,075
Ensembl chr 5:9,035,033...9,546,075
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G |
SERPINE1 |
serpin family E member 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Silicon results in increased expression of SERPINE1 protein] |
CTD |
PMID:34252510 |
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NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
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G |
SERPINH1 |
serpin family H member 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA] |
CTD |
PMID:24704557 |
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NCBI chr11:75,562,253...75,572,783
Ensembl chr11:75,562,056...75,572,783
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G |
SFTPA1 |
surfactant protein A1 |
multiple interactions |
ISO |
Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPA1 mRNA] |
CTD |
PMID:25215149 |
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NCBI chr10:79,610,939...79,615,455
Ensembl chr10:79,610,939...79,615,455
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G |
SFTPB |
surfactant protein B |
multiple interactions |
ISO |
Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPB mRNA] |
CTD |
PMID:25215149 |
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NCBI chr 2:85,657,307...85,668,741
Ensembl chr 2:85,657,314...85,668,741
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G |
SIRT1 |
sirtuin 1 |
increases expression multiple interactions |
ISO |
Thioctic Acid results in increased expression of SIRT1 protein Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT1 mRNA] Thioctic Acid results in increased expression of SIRT1 mRNA [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA] |
CTD |
PMID:22327056 PMID:37739047 |
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NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
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G |
SIRT3 |
sirtuin 3 |
multiple interactions increases expression |
ISO |
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 mRNA] Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT3 mRNA] Thioctic Acid results in increased expression of SIRT3 protein |
CTD |
PMID:22327056 PMID:37739047 |
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NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931
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G |
SLC12A2 |
solute carrier family 12 member 2 |
multiple interactions affects activity |
ISO |
[Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] promotes the reaction [Thioctic Acid results in decreased activity of Ammonia] Thioctic Acid affects the activity of SLC12A2 protein |
CTD |
PMID:23880158 |
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NCBI chr 5:128,083,766...128,189,677
Ensembl chr 5:128,083,766...128,189,677
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G |
SLC1A1 |
solute carrier family 1 member 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC1A1 mRNA] |
CTD |
PMID:32061141 |
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NCBI chr 9:4,490,468...4,587,469
Ensembl chr 9:4,490,468...4,587,469
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G |
SLC38A2 |
solute carrier family 38 member 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA] |
CTD |
PMID:23892647 |
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NCBI chr12:46,358,188...46,372,773
Ensembl chr12:46,358,188...46,372,773
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G |
SLC5A6 |
solute carrier family 5 member 6 |
increases transport multiple interactions |
EXP ISO |
SLC5A6 results in increased transport of Thioctic Acid Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Biotin]; Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid] Sodium affects the reaction [SLC5A6 results in increased transport of Thioctic Acid] |
CTD |
PMID:9516450 PMID:10329687 |
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NCBI chr 2:27,199,587...27,212,787
Ensembl chr 2:27,199,587...27,212,958
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G |
SLC7A11 |
solute carrier family 7 member 11 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC7A11 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC7A11 mRNA] |
CTD |
PMID:32061141 |
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NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349
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G |
SMAD2 |
SMAD family member 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] |
CTD |
PMID:35187969 |
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NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146
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G |
SMAD3 |
SMAD family member 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:35187969 |
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NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173
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G |
SNCA |
synuclein alpha |
multiple interactions |
EXP |
[Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Thioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein] |
CTD |
PMID:20414966 |
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NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
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G |
SOD1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of SOD1] |
CTD |
PMID:15804455 PMID:26518973 |
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NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
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G |
SOD2 |
superoxide dismutase 2 |
multiple interactions increases activity |
ISO |
Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein] [Thioctic Acid co-treated with Dietary Fats] results in decreased expression of SOD2 mRNA; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of SOD2 mRNA] Thioctic Acid results in increased activity of SOD2 protein |
CTD |
PMID:15804455 PMID:19951573 PMID:22327056 PMID:27260466 PMID:34252510 |
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NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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G |
SP1 |
Sp1 transcription factor |
multiple interactions |
ISO |
Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein |
CTD |
PMID:21351249 |
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NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
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G |
SREBF1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] |
CTD |
PMID:22464149 |
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NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
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G |
STAR |
steroidogenic acute regulatory protein |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STAR mRNA] |
CTD |
PMID:28070105 |
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NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
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G |
STAT1 |
signal transducer and activator of transcription 1 |
multiple interactions |
EXP |
Thioctic Acid affects the reaction [Zinc deficiency affects the phosphorylation of STAT1 protein]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT1 protein] |
CTD |
PMID:19635391 PMID:28086195 |
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NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960
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G |
STAT3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT3 protein] |
CTD |
PMID:19635391 PMID:28086195 |
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NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
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G |
STK11 |
serine/threonine kinase 11 |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Silicon] results in increased expression of STK11 mRNA |
CTD |
PMID:34252510 |
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NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431
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G |
SUMO1 |
small ubiquitin like modifier 1 |
increases expression |
EXP |
Thioctic Acid results in increased expression of SUMO1 protein |
CTD |
PMID:24975507 |
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NCBI chr 2:202,206,171...202,238,597
Ensembl chr 2:202,206,182...202,238,599
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G |
TFAM |
transcription factor A, mitochondrial |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Silicon results in decreased expression of TFAM mRNA] |
CTD |
PMID:34252510 |
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NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220
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G |
TGFA |
transforming growth factor alpha |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFA mRNA] |
CTD |
PMID:29233029 |
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NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
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G |
TGFB1 |
transforming growth factor beta 1 |
multiple interactions |
ISO |
Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA] Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of TGFB1 protein] |
CTD |
PMID:15309289 PMID:21251946 PMID:24704557 PMID:26276312 PMID:29760339 PMID:34252510 PMID:35187969 More...
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NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
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G |
TGFB1I1 |
transforming growth factor beta 1 induced transcript 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TGFB1I1 mRNA] |
CTD |
PMID:23608068 |
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NCBI chr16:31,472,152...31,477,960
Ensembl chr16:31,471,585...31,477,960
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G |
TGFB2 |
transforming growth factor beta 2 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TGFB2 mRNA; [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of TGFB2 mRNA |
CTD |
PMID:23830814 PMID:31068541 |
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NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
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G |
THRA |
thyroid hormone receptor alpha |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of THRA mRNA] |
CTD |
PMID:27260466 |
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NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867
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G |
TNF |
tumor necrosis factor |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TNF mRNA; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]]; Thioctic Acid affects the reaction [Paraquat affects the expression of TNF protein]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]] Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TNF mRNA] |
CTD |
PMID:15309289 PMID:23830814 PMID:25215149 PMID:26276312 PMID:29233029 PMID:29760339 PMID:35187969 More...
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NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
TNFRSF10C |
TNF receptor superfamily member 10c |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TNFRSF10B mRNA] |
CTD |
PMID:23830814 |
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NCBI chr 8:23,102,921...23,117,445
Ensembl chr 8:23,102,921...23,117,445
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G |
TNFSF10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of TNFSF10 mRNA |
CTD |
PMID:23830814 |
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NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
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G |
TNNI3 |
troponin I3, cardiac type |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] |
CTD |
PMID:21034734 |
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NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773
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G |
TP53 |
tumor protein p53 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Methotrexate results in increased expression of TP53 protein] |
CTD |
PMID:19900424 |
|
NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
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G |
TRIB3 |
tribbles pseudokinase 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA]; Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of TRIB3 mRNA] |
CTD |
PMID:23608068 PMID:23892647 |
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NCBI chr20:380,760...397,559
Ensembl chr20:362,835...397,559
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G |
TXN |
thioredoxin |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of TXN1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA] |
CTD |
PMID:23830814 PMID:31068541 |
|
NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
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G |
TXNRD1 |
thioredoxin reductase 1 |
increases reduction multiple interactions |
EXP ISO |
TXNRD1 protein results in increased reduction of Thioctic Acid Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein] |
CTD |
PMID:20810785 PMID:21172426 |
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NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
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G |
UCP2 |
uncoupling protein 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA] |
CTD |
PMID:22327056 PMID:22464149 |
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NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843
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G |
VEGFA |
vascular endothelial growth factor A |
multiple interactions increases expression |
ISO |
Cyclosporine inhibits the reaction [Thioctic Acid results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased expression of VEGFA mRNA] Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of VEGFA mRNA] |
CTD |
PMID:11596663 PMID:22488045 PMID:26276312 |
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NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
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G |
WNT5A |
Wnt family member 5A |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of WNT5A protein] |
CTD |
PMID:37739047 |
|
NCBI chr 3:55,465,715...55,505,263
Ensembl chr 3:55,465,715...55,490,539
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G |
XDH |
xanthine dehydrogenase |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Valproic Acid results in increased activity of XDH protein] |
CTD |
PMID:32662911 |
|
NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
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G |
ACE |
angiotensin I converting enzyme |
decreases activity |
ISO |
14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased activity of ACE protein |
CTD |
PMID:27428043 |
|
NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
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G |
ACE2 |
angiotensin converting enzyme 2 |
multiple interactions |
ISO |
14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased expression of ACE2 protein] |
CTD |
PMID:27428043 |
|
NCBI chr X:15,518,197...15,607,211
Ensembl chr X:15,494,566...15,607,236
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G |
AGT |
angiotensinogen |
multiple interactions decreases expression increases cleavage |
ISO |
14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form] 14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased expression of AGT protein modified form [14,15-epoxy-5,8,11-eicosatrienoic acid analog results in increased cleavage of AGT protein modified form] which results in increased abundance of angiotensin I (1-7) |
CTD |
PMID:27428043 |
|
NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
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G |
AKT1 |
AKT serine/threonine kinase 1 |
increases phosphorylation |
EXP |
14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of AKT1 protein |
CTD |
PMID:16286479 |
|
NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
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G |
CYP2C8 |
cytochrome P450 family 2 subfamily C member 8 |
increases chemical synthesis |
EXP |
CYP2C8 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid |
CTD |
PMID:12675279 |
|
NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
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G |
CYP2C9 |
cytochrome P450 family 2 subfamily C member 9 |
increases chemical synthesis multiple interactions |
EXP |
CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid] |
CTD |
PMID:12675279 |
|
NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
increases chemical synthesis multiple interactions |
EXP |
CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid] |
CTD |
PMID:12675279 |
|
NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
EPHX2 |
epoxide hydrolase 2 |
multiple interactions increases abundance |
ISO |
[Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid; [Mercuric Chloride results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid EPHX2 gene mutant form results in increased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid |
CTD |
PMID:19896470 PMID:22680237 PMID:24472606 |
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NCBI chr 8:27,491,143...27,548,626
Ensembl chr 8:27,490,781...27,545,564
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G |
FGF2 |
fibroblast growth factor 2 |
increases expression |
EXP |
14,15-epoxy-5,8,11-eicosatrienoic acid results in increased expression of FGF2 protein |
CTD |
PMID:16286479 |
|
NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
increases phosphorylation |
ISO |
14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:19464254 |
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NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
increases phosphorylation |
ISO |
14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:19464254 |
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NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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G |
RPS6KB1 |
ribosomal protein S6 kinase B1 |
increases phosphorylation |
EXP |
14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of RPS6KB1 protein |
CTD |
PMID:16286479 |
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NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
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G |
TGFB1 |
transforming growth factor beta 1 |
multiple interactions decreases secretion |
EXP |
12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [TGFB1 protein results in decreased secretion of 14,15-epoxy-5,8,11-eicosatrienoic acid] |
CTD |
PMID:28694203 |
|
NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
multiple interactions increases chemical synthesis |
EXP |
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid] |
CTD |
PMID:12675279 |
|
NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
EPHX2 |
epoxide hydrolase 2 |
increases abundance |
ISO |
EPHX2 gene mutant form results in increased abundance of 5,6-epoxy-8,11,14-eicosatrienoic acid |
CTD |
PMID:19896470 |
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NCBI chr 8:27,491,143...27,548,626
Ensembl chr 8:27,490,781...27,545,564
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G |
CYP2C9 |
cytochrome P450 family 2 subfamily C member 9 |
increases chemical synthesis multiple interactions |
EXP |
CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid] |
CTD |
PMID:12675279 |
|
NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
increases chemical synthesis multiple interactions |
EXP |
CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid] |
CTD |
PMID:12675279 |
|
NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
EPHX1 |
epoxide hydrolase 1 |
affects hydrolysis |
ISO |
EPHX1 protein affects the hydrolysis of 8,9-epoxyeicosatrienoic acid |
CTD |
PMID:28975360 |
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NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563
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G |
EPHX2 |
epoxide hydrolase 2 |
increases abundance |
ISO |
EPHX2 gene mutant form results in increased abundance of 8,9-epoxyeicosatrienoic acid |
CTD |
PMID:19896470 |
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NCBI chr 8:27,491,143...27,548,626
Ensembl chr 8:27,490,781...27,545,564
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G |
ABCC2 |
ATP binding cassette subfamily C member 2 |
increases export |
ISO |
ABCC2 protein results in increased export of 8-hydroxy-11,12-epoxyeicosa-5,9,14-trienoic acid |
CTD |
PMID:30102254 |
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NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594
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G |
ALOX5 |
arachidonate 5-lipoxygenase |
increases chemical synthesis |
EXP |
ALOX5 protein results in increased chemical synthesis of Leukotriene A4 |
CTD |
PMID:18295198 |
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NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119
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G |
LTA4H |
leukotriene A4 hydrolase |
multiple interactions increases hydrolysis |
EXP |
cyclohexene inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Oxygen inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Piperonyl Butoxide inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; propanethiol inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4] |
CTD |
PMID:2827578 |
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NCBI chr12:96,000,753...96,043,520
Ensembl chr12:96,000,753...96,043,520
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G |
MGST1 |
microsomal glutathione S-transferase 1 |
decreases activity |
ISO |
Leukotriene A4 results in decreased activity of MGST1 protein |
CTD |
PMID:9890956 |
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NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259
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G |
NFE2L2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
lipoamide inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein] |
CTD |
PMID:18258206 |
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NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
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G |
TXNRD1 |
thioredoxin reductase 1 |
increases reduction |
EXP |
TXNRD1 protein results in increased reduction of lipoamide |
CTD |
PMID:21172426 |
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NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
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G |
TXNRD2 |
thioredoxin reductase 2 |
increases reduction |
EXP |
TXNRD2 protein results in increased reduction of lipoamide |
CTD |
PMID:21172426 |
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NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820
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G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein |
CTD |
PMID:29128272 |
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NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
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G |
ACADL |
acyl-CoA dehydrogenase long chain |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACADL mRNA] |
CTD |
PMID:22464149 |
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NCBI chr 2:210,187,923...210,225,447
Ensembl chr 2:210,187,126...210,225,447
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G |
ACE |
angiotensin I converting enzyme |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE] Thioctic Acid affects the reaction [Dietary Fats affects the activity of ACE protein]; Thioctic Acid affects the reaction [Dietary Fats affects the expression of ACE mRNA] |
CTD |
PMID:26518973 PMID:27260466 |
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NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
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G |
ACHE |
acetylcholinesterase (Yt blood group) |
multiple interactions |
ISO |
[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein] [Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of ACHE protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein] |
CTD |
PMID:19669875 PMID:20663516 PMID:20730314 PMID:32911022 |
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NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
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G |
ACOX1 |
acyl-CoA oxidase 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] |
CTD |
PMID:22464149 |
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NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177
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G |
ACTA2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Mitogens results in increased expression of ACTA2 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of ACTA2 protein] |
CTD |
PMID:21251946 PMID:24704557 PMID:29760339 PMID:34252510 PMID:35187969 |
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NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339
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G |
ADA |
adenosine deaminase |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Valproic Acid] results in decreased activity of ADA protein |
CTD |
PMID:32662911 |
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NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252
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G |
ADIPOQ |
adiponectin, C1Q and collagen domain containing |
multiple interactions increases expression |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] Thioctic Acid results in increased expression of ADIPOQ mRNA; Thioctic Acid results in increased expression of ADIPOQ protein |
CTD |
PMID:22664981 |
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NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
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G |
AGT |
angiotensinogen |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Dietary Fats] results in decreased expression of AGT mRNA |
CTD |
PMID:27260466 |
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NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
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G |
AGTR1 |
angiotensin II receptor type 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of AGTR1] Thioctic Acid affects the reaction [Dietary Fats affects the expression of AGTR1A mRNA] |
CTD |
PMID:26518973 PMID:27260466 |
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NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
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G |
AKT1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
Thioctic Acid results in decreased phosphorylation of AKT1 protein Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of AKT1 mRNA] |
CTD |
PMID:21351249 PMID:27260466 |
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NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
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G |
ALAD |
aminolevulinate dehydratase |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [gallium arsenide results in decreased activity of ALAD protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] |
CTD |
PMID:19798568 PMID:20026167 PMID:20584200 PMID:21783994 |
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NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290
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G |
ALB |
albumin |
multiple interactions |
ISO EXP |
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ALB protein] ALB protein results in increased uptake of [Thioctic Acid binds to Gold] |
CTD |
PMID:24704557 PMID:28433809 |
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NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
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G |
APLN |
apelin |
multiple interactions increases secretion increases expression |
ISO |
acadesine inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA]; acadesine inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] |
CTD |
PMID:21461750 |
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NCBI chr X:129,645,259...129,654,956
Ensembl chr X:129,645,259...129,654,956
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G |
ATF4 |
activating transcription factor 4 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein] Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein] |
CTD |
PMID:23892647 PMID:30605698 |
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NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,683
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G |
ATF6 |
activating transcription factor 6 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF6 mRNA] |
CTD |
PMID:23892647 |
|
NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574
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G |
ATP1A2 |
ATPase Na+/K+ transporting subunit alpha 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Silicon results in decreased expression of ATP1A2 mRNA] |
CTD |
PMID:34252510 |
|
NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591
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G |
ATP1B1 |
ATPase Na+/K+ transporting subunit beta 1 |
multiple interactions |
ISO |
Thioctic Acid affects the reaction [Dietary Fats affects the expression of ATP1B1 mRNA] |
CTD |
PMID:27260466 |
|
NCBI chr 1:169,106,690...169,132,719
Ensembl chr 1:169,105,697...169,310,992
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G |
ATP2A2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
multiple interactions |
ISO |
Thioctic Acid promotes the reaction [Dietary Fats results in decreased expression of ATP2A2 mRNA] |
CTD |
PMID:27260466 |
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NCBI chr12:110,280,616...110,351,093
Ensembl chr12:110,280,756...110,351,093
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G |
BAX |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased localization of BAX protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of BAX protein] Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BAX mRNA] [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of BAX mRNA; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX protein] |
CTD |
PMID:15735709 PMID:23830814 PMID:23892647 PMID:27544635 PMID:30605698 PMID:32061141 PMID:34133789 More...
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NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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G |
BBC3 |
BCL2 binding component 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BBC3 mRNA] |
CTD |
PMID:23892647 |
|
NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766
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G |
BCHE |
butyrylcholinesterase |
multiple interactions |
ISO |
[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein] Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of BCHE protein] |
CTD |
PMID:20663516 PMID:32911022 |
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NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
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G |
BCL2 |
BCL2 apoptosis regulator |
multiple interactions decreases response to substance |
EXP ISO |
Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in decreased expression of BCL2 protein]; Thioctic Acid results in increased degradation of and results in decreased expression of BCL2 protein Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA] Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 protein] BCL2 protein results in decreased susceptibility to Thioctic Acid |
CTD |
PMID:16990509 PMID:21600978 PMID:23830814 PMID:27260466 PMID:27544635 PMID:30605698 PMID:32061141 PMID:34133789 More...
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NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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G |
BCL2L1 |
BCL2 like 1 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of BCL2L1 mRNA |
CTD |
PMID:23830814 |
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NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
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G |
BRCA2 |
BRCA2 DNA repair associated |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of BRCA2 mRNA] |
CTD |
PMID:23608068 |
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NCBI chr13:32,315,508...32,400,268
Ensembl chr13:32,315,086...32,400,268
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G |
C1QA |
complement C1q A chain |
decreases expression |
ISO |
Thioctic Acid results in decreased expression of C1QA mRNA |
CTD |
PMID:19555370 |
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NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,635,077...22,639,678
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G |
C4B |
complement C4B (Chido/Rodgers blood group) |
decreases expression |
ISO |
Thioctic Acid results in decreased expression of C4B mRNA |
CTD |
PMID:19555370 |
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NCBI chr 6:32,014,795...32,035,418
Ensembl chr 6:32,014,795...32,035,418
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G |
CALB2 |
calbindin 2 |
multiple interactions |
ISO |
Thioctic Acid affects the reaction [Propylthiouracil results in increased expression of CALB2 mRNA] |
CTD |
PMID:31068541 |
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NCBI chr16:71,358,723...71,390,433
Ensembl chr16:71,358,713...71,390,436
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G |
CALM1 |
calmodulin 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of CALM1 mRNA] |
CTD |
PMID:26165643 |
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NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268
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G |
CAMK2A |
calcium/calmodulin dependent protein kinase II alpha |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of CAMK2A protein] |
CTD |
PMID:37739047 |
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NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093
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G |
CASP3 |
caspase 3 |
multiple interactions increases expression increases activity |
ISO EXP |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein] Thioctic Acid results in increased expression of CASP3 protein modified form Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein] Thioctic Acid results in increased activity of CASP3 protein [Ryanodine co-treated with Thioctic Acid] results in decreased activity of CASP3 protein; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP3 protein modified form]; Thioctic Acid inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein] |
CTD |
PMID:15909127 PMID:17079870 PMID:19951573 PMID:21062633 PMID:21763304 PMID:23892647 PMID:27544635 PMID:29214690 PMID:30605698 PMID:32061141 PMID:34133789 More...
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CASP8 |
caspase 8 |
multiple interactions |
ISO EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein] |
CTD |
PMID:23830814 PMID:27544635 |
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NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
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G |
CASP9 |
caspase 9 |
increases activity multiple interactions |
EXP ISO |
Thioctic Acid results in increased activity of CASP9 protein Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein] [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CASP9 mRNA; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP9 protein modified form]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP9 protein] |
CTD |
PMID:16990509 PMID:19951573 PMID:23830814 PMID:27544635 PMID:30605698 |
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NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
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G |
CAT |
catalase |
multiple interactions increases expression increases activity |
ISO EXP |
Thioctic Acid inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of CAT mRNA] Thioctic Acid results in increased expression of CAT mRNA [Paraquat co-treated with Thioctic Acid] results in increased expression of CAT mRNA Thioctic Acid results in increased activity of CAT protein [acetovanillone results in increased susceptibility to Thioctic Acid] inhibits the reaction [Mitogens results in decreased activity of CAT protein]; Succimer promotes the reaction [Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Valproic Acid results in decreased activity of CAT protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]]; Thioctic Acid promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]] |
CTD |
PMID:15998567 PMID:19368863 PMID:19699728 PMID:19715735 PMID:21763304 PMID:22623521 PMID:23649336 PMID:26276312 PMID:27260466 PMID:27581792 PMID:28880400 PMID:29214690 PMID:29760339 PMID:32662911 PMID:34252510 More...
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NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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G |
CCL2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of CCL2 mRNA] |
CTD |
PMID:22488045 |
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NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
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G |
CCND1 |
cyclin D1 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein] |
CTD |
PMID:21600978 |
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NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
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G |
CD36 |
CD36 molecule (CD36 blood group) |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]] |
CTD |
PMID:21315065 |
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NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277
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G |
CD86 |
CD86 molecule |
increases expression |
EXP |
Thioctic Acid results in increased expression of CD86 protein |
CTD |
PMID:19033392 |
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NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
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G |
CD8A |
CD8 subunit alpha |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA |
CTD |
PMID:23830814 |
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NCBI chr 2:86,784,605...86,808,396
Ensembl chr 2:86,784,610...86,808,396
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G |
CDX4 |
caudal type homeobox 4 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of CDX4 mRNA] |
CTD |
PMID:23608068 |
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NCBI chr X:73,447,053...73,455,171
Ensembl chr X:73,447,053...73,455,171
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G |
CHAT |
choline O-acetyltransferase |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein |
CTD |
PMID:19669875 |
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NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942
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G |
CNTF |
ciliary neurotrophic factor |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone results in decreased activity of CNTF protein] |
CTD |
PMID:19635391 |
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NCBI chr11:58,622,665...58,625,733
Ensembl chr11:58,622,665...58,625,733
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G |
COL1A1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of COL1A1 mRNA; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA] Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL1A1 mRNA] |
CTD |
PMID:21251946 PMID:23830814 PMID:34252510 PMID:35187969 |
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NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
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G |
COL3A1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL3A1 mRNA] |
CTD |
PMID:34252510 |
|
NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
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G |
COX4I1 |
cytochrome c oxidase subunit 4I1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Silicon results in decreased expression of COX4I1 mRNA] |
CTD |
PMID:34252510 |
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NCBI chr16:85,799,695...85,807,068
Ensembl chr16:85,798,633...85,807,068
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G |
CPT1A |
carnitine palmitoyltransferase 1A |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] |
CTD |
PMID:22464149 |
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NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410
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G |
CREB1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:32061141 |
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NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988
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G |
CRP |
C-reactive protein |
multiple interactions |
ISO |
Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein] |
CTD |
PMID:26276312 |
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NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
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G |
CRYAA |
crystallin alpha A |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [naphthalene results in increased cleavage of CRYAA protein] |
CTD |
PMID:20597648 |
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NCBI chr21:43,169,008...43,172,810
Ensembl chr21:43,169,008...43,172,805
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G |
CTNNB1 |
catenin beta 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of CTNNB1 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of CTNNB1 protein] |
CTD |
PMID:34133789 |
|
NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
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G |
CTSD |
cathepsin D |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] |
CTD |
PMID:12841641 |
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NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573
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G |
CTSS |
cathepsin S |
decreases expression |
ISO |
Thioctic Acid results in decreased expression of CTSS mRNA |
CTD |
PMID:19555370 |
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NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,079...150,765,957
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G |
CXCL8 |
C-X-C motif chemokine ligand 8 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of CXCL8 mRNA] |
CTD |
PMID:30758914 |
|
NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
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G |
CYBA |
cytochrome b-245 alpha chain |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of CYBA mRNA] |
CTD |
PMID:35187969 |
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NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083
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G |
CYBB |
cytochrome b-245 beta chain |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB] |
CTD |
PMID:26518973 |
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NCBI chr X:37,780,059...37,813,461
Ensembl chr X:37,780,018...37,813,461
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G |
CYCS |
cytochrome c, somatic |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Streptozocin affects the localization of CYCS protein] |
CTD |
PMID:19951573 |
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NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
multiple interactions |
ISO |
[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] |
CTD |
PMID:21932800 |
|
NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
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G |
CYP1A2 |
cytochrome P450 family 1 subfamily A member 2 |
multiple interactions |
ISO EXP |
[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:21932800 PMID:24120545 |
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NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
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G |
CYP2C19 |
cytochrome P450 family 2 subfamily C member 19 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:24120545 |
|
NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
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G |
CYP2C8 |
cytochrome P450 family 2 subfamily C member 8 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:24120545 |
|
NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
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G |
CYP2C9 |
cytochrome P450 family 2 subfamily C member 9 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:24120545 |
|
NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
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G |
CYP2D6 |
cytochrome P450 family 2 subfamily D member 6 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:24120545 |
|
NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
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G |
CYP2E1 |
cytochrome P450 family 2 subfamily E member 1 |
multiple interactions |
ISO |
Thioctic Acid affects the reaction [cyanoginosin LR affects the expression of CYP2E1 protein] |
CTD |
PMID:32061150 |
|
NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:24120545 |
|
NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
DAB1 |
DAB adaptor protein 1 |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of DAB1 mRNA |
CTD |
PMID:31068541 |
|
NCBI chr 1:56,994,778...58,546,726
Ensembl chr 1:56,994,778...58,546,734
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G |
DDIT3 |
DNA damage inducible transcript 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of DDIT3 protein] Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein] |
CTD |
PMID:23892647 PMID:30605698 |
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NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
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G |
DGAT2 |
diacylglycerol O-acyltransferase 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of DGAT2 mRNA] |
CTD |
PMID:22464149 |
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NCBI chr11:75,768,778...75,801,534
Ensembl chr11:75,759,512...75,801,535
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G |
DIO1 |
iodothyronine deiodinase 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of DIO1 mRNA] |
CTD |
PMID:27260466 |
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NCBI chr 1:53,894,187...53,911,086
Ensembl chr 1:53,891,239...53,911,086
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G |
DLD |
dihydrolipoamide dehydrogenase |
multiple interactions |
ISO |
[5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid] |
CTD |
PMID:21551353 |
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NCBI chr 7:107,891,107...107,921,198
Ensembl chr 7:107,891,162...107,931,730
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G |
DLG4 |
discs large MAGUK scaffold protein 4 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of DLG4 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of DLG4 protein] |
CTD |
PMID:34133789 |
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NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,841
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G |
DNM1L |
dynamin 1 like |
decreases expression multiple interactions |
ISO |
Thioctic Acid results in decreased expression of DNM1L mRNA Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L mRNA]; Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L protein] |
CTD |
PMID:37739047 |
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NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650
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G |
DRD2 |
dopamine receptor D2 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]; Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein] |
CTD |
PMID:20730801 |
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NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
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G |
EIF2A |
eukaryotic translation initiation factor 2A |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2A protein] |
CTD |
PMID:23892647 |
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NCBI chr 3:150,546,787...150,586,016
Ensembl chr 3:150,546,678...150,586,016
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G |
EIF2S1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form] |
CTD |
PMID:30605698 |
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NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516
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G |
FAS |
Fas cell surface death receptor |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein] |
CTD |
PMID:27544635 |
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NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
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G |
FIS1 |
fission, mitochondrial 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of FIS1 mRNA] |
CTD |
PMID:37739047 |
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NCBI chr 7:101,239,472...101,245,081
Ensembl chr 7:101,239,458...101,252,316
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G |
FLT1 |
fms related receptor tyrosine kinase 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA] |
CTD |
PMID:23608068 |
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NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145
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G |
FN1 |
fibronectin 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Diazinon results in decreased expression of FN1 protein] Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA] |
CTD |
PMID:32911022 PMID:35187969 |
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NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073
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G |
FOS |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of FOS mRNA |
CTD |
PMID:31068541 |
|
NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
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G |
FOXO3 |
forkhead box O3 |
decreases acetylation multiple interactions |
ISO |
Thioctic Acid results in decreased acetylation of FOXO3 protein [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein |
CTD |
PMID:22327056 |
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NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
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G |
FRAS1 |
Fraser extracellular matrix complex subunit 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FRAS1 mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr 4:78,057,323...78,544,269
Ensembl chr 4:78,057,323...78,544,269
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G |
FSHB |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of FSHB protein] |
CTD |
PMID:20957662 |
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NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261
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G |
FZD2 |
frizzled class receptor 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of FZD2 protein] |
CTD |
PMID:34133789 |
|
NCBI chr17:44,557,484...44,561,262
Ensembl chr17:44,557,484...44,561,262
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G |
GAD1 |
glutamate decarboxylase 1 |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GAD1 mRNA |
CTD |
PMID:31068541 |
|
NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151
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G |
GCLC |
glutamate-cysteine ligase catalytic subunit |
increases expression multiple interactions |
EXP ISO |
Thioctic Acid results in increased expression of GCLC mRNA Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA]; Thioctic Acid results in increased expression of and results in increased activity of GCLC protein Thioctic Acid inhibits the reaction [Silicon results in decreased expression of GCLC protein] Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein] |
CTD |
PMID:16249512 PMID:17940886 PMID:26365678 PMID:27298056 PMID:32061141 PMID:34252510 More...
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NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
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G |
GCLM |
glutamate-cysteine ligase modifier subunit |
increases expression multiple interactions |
EXP ISO |
Thioctic Acid results in increased expression of GCLM mRNA; Thioctic Acid results in increased expression of GCLM protein Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM mRNA]; Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM protein] Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM protein] |
CTD |
PMID:16249512 PMID:26365678 PMID:32061141 |
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NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456
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G |
GFAP |
glial fibrillary acidic protein |
decreases expression |
ISO |
Thioctic Acid results in decreased expression of GFAP mRNA |
CTD |
PMID:19555370 |
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NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
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G |
GGT1 |
gamma-glutamyltransferase 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein] |
CTD |
PMID:24704557 |
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NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,594,811...24,629,005
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G |
GJA1 |
gap junction protein alpha 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Cadmium affects the localization of GJA1 protein]; Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of GJA1 mRNA] Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA] |
CTD |
PMID:26165643 PMID:27260466 |
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NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
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G |
GLS |
glutaminase |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GLS protein] |
CTD |
PMID:32061141 |
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NCBI chr 2:190,880,821...190,965,552
Ensembl chr 2:190,880,821...190,965,552
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G |
GNRHR |
gonadotropin releasing hormone receptor |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GNRHR mRNA] |
CTD |
PMID:28070105 |
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NCBI chr 4:67,737,118...67,754,388
Ensembl chr 4:67,737,118...67,754,388
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G |
GPT |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GPT protein] Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of GPT protein] |
CTD |
PMID:24704557 PMID:37739047 |
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NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
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G |
GPX1 |
glutathione peroxidase 1 |
increases expression multiple interactions |
EXP ISO |
Thioctic Acid results in increased expression of GPX1 mRNA Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GPX1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GPX1 mRNA] |
CTD |
PMID:23649336 PMID:32061141 |
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NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
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G |
GPX2 |
glutathione peroxidase 2 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GPX2 mRNA |
CTD |
PMID:23830814 |
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NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746
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G |
GPX3 |
glutathione peroxidase 3 |
increases expression multiple interactions |
EXP |
Thioctic Acid results in increased expression of GPX3 mRNA [Paraquat co-treated with Thioctic Acid] results in increased expression of GPX3 mRNA |
CTD |
PMID:23649336 |
|
NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988
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G |
GPX5 |
glutathione peroxidase 5 |
increases expression |
EXP |
Thioctic Acid results in increased expression of GPX5 mRNA |
CTD |
PMID:23649336 |
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NCBI chr 6:28,525,881...28,534,955
Ensembl chr 6:28,525,881...28,534,955
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G |
GRIN1 |
glutamate ionotropic receptor NMDA type subunit 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 protein] |
CTD |
PMID:32061141 |
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NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756
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G |
GRIN2A |
glutamate ionotropic receptor NMDA type subunit 2A |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GRIN2A mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A protein] |
CTD |
PMID:31068541 PMID:32061141 |
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NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928
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G |
GSK3B |
glycogen synthase kinase 3 beta |
increases phosphorylation multiple interactions |
ISO |
Thioctic Acid results in increased phosphorylation of GSK3B protein Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of GSK3B protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of GSK3B protein] Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA] |
CTD |
PMID:19879292 PMID:27260466 PMID:34133789 |
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NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
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G |
GSR |
glutathione-disulfide reductase |
multiple interactions increases expression |
ISO EXP |
Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of GSR protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GSR protein] Thioctic Acid inhibits the reaction [cyanoginosin LR results in decreased activity of GSR protein] Thioctic Acid results in increased expression of GSR mRNA |
CTD |
PMID:19699728 PMID:22623521 PMID:23649336 PMID:27581792 PMID:32061150 |
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NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
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G |
GSS |
glutathione synthetase |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of GSS protein] |
CTD |
PMID:32061141 |
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NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027
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G |
GSTM1 |
glutathione S-transferase mu 1 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA [Dietary Fats co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA |
CTD |
PMID:18367378 PMID:23830814 |
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NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
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G |
GSTP1 |
glutathione S-transferase pi 1 |
multiple interactions increases expression |
ISO |
[Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; Thioctic Acid results in increased expression of and results in increased activity of GSTP1 protein Thioctic Acid results in increased expression of GSTP1 mRNA |
CTD |
PMID:20237067 |
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NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
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G |
GUSB |
glucuronidase beta |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GUSB protein] |
CTD |
PMID:19699728 |
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NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215
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G |
HAVCR1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
EXP |
[Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein |
CTD |
PMID:28433809 |
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NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396
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G |
HMOX1 |
heme oxygenase 1 |
multiple interactions increases expression |
EXP ISO |
[Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of HMOX1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein] Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 protein] Thioctic Acid results in increased expression of HMOX1 mRNA; Thioctic Acid results in increased expression of HMOX1 protein Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of HMOX1 mRNA] |
CTD |
PMID:19033392 PMID:21315065 PMID:22488045 PMID:23649336 PMID:23942037 PMID:24361488 PMID:27260466 PMID:27298056 PMID:30758914 PMID:31319135 PMID:32061141 More...
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NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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G |
HS1BP3 |
HCLS1 binding protein 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of HS1BP3 mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr 2:20,553,861...20,651,098
Ensembl chr 2:20,560,448...20,651,130
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G |
HSPA1A |
heat shock protein family A (Hsp70) member 1A |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA] |
CTD |
PMID:28880400 |
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NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
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G |
HSPA5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HSPA5 protein] Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein] |
CTD |
PMID:23892647 PMID:30605698 |
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NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
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G |
IGFBP3 |
insulin like growth factor binding protein 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA] |
CTD |
PMID:28880400 |
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NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874
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G |
IL10 |
interleukin 10 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of IL10]; Thioctic Acid promotes the reaction [Carrageenan results in increased expression of IL10 mRNA] |
CTD |
PMID:19735303 PMID:26518973 |
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NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
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G |
IL1A |
interleukin 1 alpha |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of IL1A mRNA |
CTD |
PMID:31068541 |
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NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
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G |
IL1B |
interleukin 1 beta |
multiple interactions |
ISO EXP |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL1B mRNA; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL1B] Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] |
CTD |
PMID:23830814 PMID:24975507 PMID:26518973 |
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NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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G |
IL2 |
interleukin 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL2 protein] |
CTD |
PMID:21195065 |
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NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
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G |
IL22RA2 |
interleukin 22 receptor subunit alpha 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of IL22RA2 mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr 6:137,143,820...137,173,644
Ensembl chr 6:137,143,820...137,173,648
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G |
IL4 |
interleukin 4 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL4 mRNA |
CTD |
PMID:23830814 |
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NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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G |
IL6 |
interleukin 6 |
multiple interactions |
ISO EXP |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of IL6 mRNA] [Thioctic Acid binds to Gold] which results in increased expression of IL6 protein acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL6]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]] |
CTD |
PMID:22488045 PMID:26518973 PMID:28433809 PMID:29233029 PMID:29760339 |
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NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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G |
INS |
insulin |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein] |
CTD |
PMID:16505238 |
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NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
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G |
INS-IGF2 |
INS-IGF2 readthrough |
multiple interactions |
ISO |
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased secretion of INS1 protein]] |
CTD |
PMID:21461750 PMID:29760339 |
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NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
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G |
IRF1 |
interferon regulatory factor 1 |
multiple interactions |
EXP |
Thioctic Acid results in increased sumoylation of and results in decreased activity of IRF1 protein |
CTD |
PMID:24975507 |
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NCBI chr 5:132,481,609...132,490,773
Ensembl chr 5:132,440,440...132,508,719
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression increases activity |
ISO |
[Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer] Thioctic Acid results in increased expression of JUN protein Thioctic Acid results in increased activity of JUN protein |
CTD |
PMID:20237067 |
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NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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G |
KEAP1 |
kelch like ECH associated protein 1 |
increases expression multiple interactions |
EXP ISO |
Thioctic Acid results in increased expression of KEAP1 protein Thioctic Acid inhibits the reaction [Silicon results in increased expression of KEAP1 protein] |
CTD |
PMID:19033392 PMID:34252510 |
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NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
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G |
LDHC |
lactate dehydrogenase C |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of LDHC protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased expression of LDHC protein] |
CTD |
PMID:21195065 PMID:27581792 |
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NCBI chr11:18,412,318...18,452,063
Ensembl chr11:18,412,318...18,452,063
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G |
LEP |
leptin |
decreases secretion decreases expression |
ISO |
Thioctic Acid results in decreased secretion of LEP protein Thioctic Acid results in decreased expression of LEP mRNA; Thioctic Acid results in decreased expression of LEP protein |
CTD |
PMID:21351249 |
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NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629
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G |
LHB |
luteinizing hormone subunit beta |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of LHB protein]; Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LHB mRNA] |
CTD |
PMID:20957662 PMID:28070105 |
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NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091
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G |
LIPE |
lipase E, hormone sensitive type |
multiple interactions increases phosphorylation |
ISO |
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Thioctic Acid results in increased phosphorylation of LIPE protein] |
CTD |
PMID:22941773 |
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NCBI chr19:42,401,514...42,427,388
Ensembl chr19:42,401,514...42,427,388
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
affects activity multiple interactions |
ISO |
Thioctic Acid affects the activity of MAPK1 protein Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK1 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK1 protein] |
CTD |
PMID:15909127 PMID:21251946 PMID:32061141 |
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NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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G |
MAPK14 |
mitogen-activated protein kinase 14 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK14 mRNA |
CTD |
PMID:23830814 |
|
NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK3 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK3 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK3 protein] |
CTD |
PMID:21251946 PMID:23830814 PMID:32061141 |
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NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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G |
MAPK8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK8 mRNA |
CTD |
PMID:23830814 |
|
NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
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G |
MAPT |
microtubule associated protein tau |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of MAPT protein] |
CTD |
PMID:34133789 |
|
NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334
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G |
MFF |
mitochondrial fission factor |
multiple interactions decreases expression |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFF mRNA] Thioctic Acid results in decreased expression of MFF mRNA |
CTD |
PMID:37739047 |
|
NCBI chr 2:227,325,251...227,357,836
Ensembl chr 2:227,325,151...227,357,833
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G |
MFN2 |
mitofusin 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFN2 mRNA] |
CTD |
PMID:37739047 |
|
NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211
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G |
MIR21 |
microRNA 21 |
multiple interactions |
ISO |
Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA] |
CTD |
PMID:26276312 |
|
NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
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G |
MIR210 |
microRNA 210 |
multiple interactions |
ISO |
[Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]] |
CTD |
PMID:26276312 |
|
NCBI chr11:568,089...568,198
Ensembl chr11:568,089...568,198
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G |
MMP12 |
matrix metallopeptidase 12 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA |
CTD |
PMID:23830814 |
|
NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982
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G |
MMP13 |
matrix metallopeptidase 13 |
multiple interactions |
EXP ISO |
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein] Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA] |
CTD |
PMID:24975507 PMID:29233029 |
|
NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
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G |
MMP2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of MMP2 mRNA |
CTD |
PMID:23830814 |
|
NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
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G |
MMP3 |
matrix metallopeptidase 3 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] |
CTD |
PMID:24975507 |
|
NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
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G |
MSR1 |
macrophage scavenger receptor 1 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]] |
CTD |
PMID:21315065 |
|
NCBI chr 8:16,107,881...16,192,651
Ensembl chr 8:16,107,878...16,567,490
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G |
MT1X |
metallothionein 1X |
multiple interactions |
ISO |
[Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MT1 mRNA |
CTD |
PMID:18367378 |
|
NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
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G |
MVD |
mevalonate diphosphate decarboxylase |
multiple interactions |
ISO |
[Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MVD mRNA |
CTD |
PMID:18367378 |
|
NCBI chr16:88,651,940...88,663,091
Ensembl chr16:88,651,935...88,663,161
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G |
MYC |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of MYC protein] |
CTD |
PMID:21600978 |
|
NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
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G |
NCF1 |
neutrophil cytosolic factor 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of NCF1] |
CTD |
PMID:26518973 |
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NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315
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G |
NFE2L2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions affects localization increases expression increases activity decreases expression |
EXP ISO |
[Paraquat co-treated with Thioctic Acid] results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NFE2L2 mRNA]; Thioctic Acid promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thioctic Acid results in increased expression of and affects the localization of NFE2L2 protein Thioctic Acid affects the localization of NFE2L2 protein Thioctic Acid results in increased expression of NFE2L2 mRNA; Thioctic Acid results in increased expression of NFE2L2 protein Thioctic Acid results in increased activity of NFE2L2 protein [Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer] Thioctic Acid results in decreased expression of NFE2L2 mRNA; Thioctic Acid results in decreased expression of NFE2L2 protein [Thioctic Acid co-treated with cyanoginosin LR] results in increased expression of NFE2L2 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of NFE2L2 protein] |
CTD |
PMID:17197552 PMID:18258206 PMID:20237067 PMID:22488045 PMID:23649336 PMID:24361488 PMID:27260466 PMID:27298056 PMID:30758914 PMID:31319135 PMID:32061141 PMID:32061150 PMID:34252510 PMID:36880193 More...
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NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
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G |
NFKB1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
EXP ISO |
Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein] [Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA |
CTD |
PMID:21600978 PMID:31068541 |
|
NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
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G |
NFKBIA |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of NFKBIA protein] |
CTD |
PMID:34133789 |
|
NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
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G |
NGFR |
nerve growth factor receptor |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TNFRSF10B mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008
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G |
NOS2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of NOS2]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA] |
CTD |
PMID:15453632 PMID:21763304 PMID:29233029 |
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NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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G |
NOS3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] |
CTD |
PMID:27260466 |
|
NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
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G |
NOX1 |
NADPH oxidase 1 |
multiple interactions |
ISO |
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]] |
CTD |
PMID:29760339 |
|
NCBI chr X:100,843,324...100,874,359
Ensembl chr X:100,843,324...100,874,359
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G |
NOX4 |
NADPH oxidase 4 |
multiple interactions |
ISO |
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]] Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA] |
CTD |
PMID:29760339 PMID:35187969 |
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NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
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G |
NQO1 |
NAD(P)H quinone dehydrogenase 1 |
increases activity increases expression multiple interactions |
EXP ISO |
Thioctic Acid results in increased activity of NQO1 protein Thioctic Acid results in increased expression of NQO1 mRNA; Thioctic Acid results in increased expression of NQO1 protein [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 protein] [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA] |
CTD |
PMID:12180195 PMID:17940886 PMID:19033392 PMID:23649336 PMID:23830814 PMID:30758914 PMID:31068541 PMID:31319135 More...
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NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
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G |
OPA1 |
OPA1 mitochondrial dynamin like GTPase |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of OPA1 mRNA] |
CTD |
PMID:37739047 |
|
NCBI chr 3:193,593,208...193,697,811
Ensembl chr 3:193,593,144...193,697,811
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G |
OTX2 |
orthodenticle homeobox 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA] |
CTD |
PMID:31068541 |
|
NCBI chr14:56,799,905...56,810,479
Ensembl chr14:56,799,905...56,816,693
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G |
PAH |
phenylalanine hydroxylase |
decreases expression |
ISO |
Thioctic Acid results in decreased expression of PAH mRNA |
CTD |
PMID:19555370 |
|
NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
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G |
PCDHB6 |
protocadherin beta 6 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of PCDHB6 mRNA] |
CTD |
PMID:23608068 |
|
NCBI chr 5:141,150,057...141,153,287
Ensembl chr 5:141,150,057...141,153,287
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G |
PCNA |
proliferating cell nuclear antigen |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of PCNA protein] |
CTD |
PMID:21251946 |
|
NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
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G |
PINK1 |
PTEN induced kinase 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PINK1 mRNA] |
CTD |
PMID:37739047 |
|
NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511
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G |
PLAAT3 |
phospholipase A and acyltransferase 3 |
decreases activity decreases expression |
ISO |
Thioctic Acid results in decreased activity of PLAAT3 protein Thioctic Acid results in decreased expression of PLAAT3 mRNA |
CTD |
PMID:22941773 |
|
NCBI chr11:63,574,462...63,616,927
Ensembl chr11:63,573,195...63,616,883
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G |
PLIN1 |
perilipin 1 |
increases phosphorylation |
ISO |
Thioctic Acid results in increased phosphorylation of PLIN1 protein |
CTD |
PMID:22941773 |
|
NCBI chr15:89,664,367...89,679,367
Ensembl chr15:89,664,367...89,679,427
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G |
POR |
cytochrome p450 oxidoreductase |
multiple interactions decreases activity |
ISO EXP |
[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; [Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:16391466 PMID:21932800 PMID:24120545 |
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NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
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G |
PPARA |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA] |
CTD |
PMID:22464149 |
|
NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755
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G |
PPARG |
peroxisome proliferator activated receptor gamma |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Dietary Fats] results in increased expression of PPARG mRNA |
CTD |
PMID:22464149 |
|
NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
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G |
PPARGC1A |
PPARG coactivator 1 alpha |
multiple interactions decreases expression increases expression |
EXP ISO |
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein Thioctic Acid results in decreased expression of PPARGC1A protein [Thioctic Acid co-treated with Silicon] results in increased expression of PPARGC1A protein; Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of PPARGC1A mRNA] Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA] Thioctic Acid results in increased expression of PPARGC1A protein |
CTD |
PMID:20414966 PMID:22464149 PMID:34252510 PMID:37739047 |
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NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
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G |
PPARGC1B |
PPARG coactivator 1 beta |
multiple interactions decreases acetylation |
ISO |
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA] Thioctic Acid results in decreased acetylation of PPARGC1B protein |
CTD |
PMID:22327056 PMID:22464149 |
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NCBI chr 5:149,730,310...149,857,959
Ensembl chr 5:149,730,298...149,855,022
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G |
PRDX3 |
peroxiredoxin 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRDX3 mRNA] |
CTD |
PMID:37739047 |
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NCBI chr10:119,167,720...119,178,812
Ensembl chr10:119,167,720...119,178,812
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G |
PRKAA2 |
protein kinase AMP-activated catalytic subunit alpha 2 |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Silicon] results in increased expression of PRKAA2 mRNA |
CTD |
PMID:34252510 |
|
NCBI chr 1:56,645,314...56,715,335
Ensembl chr 1:56,645,314...56,715,335
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G |
PRKN |
parkin RBR E3 ubiquitin protein ligase |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRKN mRNA] |
CTD |
PMID:37739047 |
|
NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775
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G |
PSEN1 |
presenilin 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of PSEN1 protein] |
CTD |
PMID:34133789 |
|
NCBI chr14:73,136,417...73,223,691
Ensembl chr14:73,136,418...73,223,691
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]]; Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]] |
CTD |
PMID:19735303 PMID:23830814 PMID:26276312 |
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NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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G |
RELA |
RELA proto-oncogene, NF-kB subunit |
multiple interactions decreases phosphorylation |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of RELA protein] Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of RELA protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA mRNA] Thioctic Acid results in decreased phosphorylation of RELA protein |
CTD |
PMID:22488045 PMID:29233029 PMID:34133789 |
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NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
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G |
RELN |
reelin |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Propylthiouracil] results in increased expression of RELN mRNA |
CTD |
PMID:31068541 |
|
NCBI chr 7:103,471,789...103,989,658
Ensembl chr 7:103,471,381...103,989,658
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G |
S100B |
S100 calcium binding protein B |
multiple interactions |
ISO |
[Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein] |
CTD |
PMID:23880158 |
|
NCBI chr21:46,598,604...46,605,082
Ensembl chr21:46,598,604...46,605,208
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G |
SEMA5A |
semaphorin 5A |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of SEMA5A mRNA] |
CTD |
PMID:23608068 |
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NCBI chr 5:9,035,033...9,546,075
Ensembl chr 5:9,035,033...9,546,075
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G |
SERPINE1 |
serpin family E member 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Silicon results in increased expression of SERPINE1 protein] |
CTD |
PMID:34252510 |
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NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
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G |
SERPINH1 |
serpin family H member 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA] |
CTD |
PMID:24704557 |
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NCBI chr11:75,562,253...75,572,783
Ensembl chr11:75,562,056...75,572,783
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G |
SFTPA1 |
surfactant protein A1 |
multiple interactions |
ISO |
Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPA1 mRNA] |
CTD |
PMID:25215149 |
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NCBI chr10:79,610,939...79,615,455
Ensembl chr10:79,610,939...79,615,455
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G |
SFTPB |
surfactant protein B |
multiple interactions |
ISO |
Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPB mRNA] |
CTD |
PMID:25215149 |
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NCBI chr 2:85,657,307...85,668,741
Ensembl chr 2:85,657,314...85,668,741
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G |
SIRT1 |
sirtuin 1 |
increases expression multiple interactions |
ISO |
Thioctic Acid results in increased expression of SIRT1 protein Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT1 mRNA] Thioctic Acid results in increased expression of SIRT1 mRNA [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA] |
CTD |
PMID:22327056 PMID:37739047 |
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NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
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G |
SIRT3 |
sirtuin 3 |
multiple interactions increases expression |
ISO |
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 mRNA] Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT3 mRNA] Thioctic Acid results in increased expression of SIRT3 protein |
CTD |
PMID:22327056 PMID:37739047 |
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NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931
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G |
SLC12A2 |
solute carrier family 12 member 2 |
multiple interactions affects activity |
ISO |
[Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] promotes the reaction [Thioctic Acid results in decreased activity of Ammonia] Thioctic Acid affects the activity of SLC12A2 protein |
CTD |
PMID:23880158 |
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NCBI chr 5:128,083,766...128,189,677
Ensembl chr 5:128,083,766...128,189,677
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G |
SLC1A1 |
solute carrier family 1 member 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC1A1 mRNA] |
CTD |
PMID:32061141 |
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NCBI chr 9:4,490,468...4,587,469
Ensembl chr 9:4,490,468...4,587,469
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G |
SLC38A2 |
solute carrier family 38 member 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA] |
CTD |
PMID:23892647 |
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NCBI chr12:46,358,188...46,372,773
Ensembl chr12:46,358,188...46,372,773
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G |
SLC5A6 |
solute carrier family 5 member 6 |
increases transport multiple interactions |
EXP ISO |
SLC5A6 results in increased transport of Thioctic Acid Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Biotin]; Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid] Sodium affects the reaction [SLC5A6 results in increased transport of Thioctic Acid] |
CTD |
PMID:9516450 PMID:10329687 |
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NCBI chr 2:27,199,587...27,212,787
Ensembl chr 2:27,199,587...27,212,958
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G |
SLC7A11 |
solute carrier family 7 member 11 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC7A11 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC7A11 mRNA] |
CTD |
PMID:32061141 |
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NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349
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G |
SMAD2 |
SMAD family member 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] |
CTD |
PMID:35187969 |
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NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146
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G |
SMAD3 |
SMAD family member 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:35187969 |
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NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173
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G |
SNCA |
synuclein alpha |
multiple interactions |
EXP |
[Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Thioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein] |
CTD |
PMID:20414966 |
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NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
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G |
SOD1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of SOD1] |
CTD |
PMID:15804455 PMID:26518973 |
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NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
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G |
SOD2 |
superoxide dismutase 2 |
multiple interactions increases activity |
ISO |
Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein] [Thioctic Acid co-treated with Dietary Fats] results in decreased expression of SOD2 mRNA; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of SOD2 mRNA] Thioctic Acid results in increased activity of SOD2 protein |
CTD |
PMID:15804455 PMID:19951573 PMID:22327056 PMID:27260466 PMID:34252510 |
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NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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G |
SP1 |
Sp1 transcription factor |
multiple interactions |
ISO |
Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein |
CTD |
PMID:21351249 |
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NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
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G |
SREBF1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] |
CTD |
PMID:22464149 |
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NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
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G |
STAR |
steroidogenic acute regulatory protein |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STAR mRNA] |
CTD |
PMID:28070105 |
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NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
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G |
STAT1 |
signal transducer and activator of transcription 1 |
multiple interactions |
EXP |
Thioctic Acid affects the reaction [Zinc deficiency affects the phosphorylation of STAT1 protein]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT1 protein] |
CTD |
PMID:19635391 PMID:28086195 |
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NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960
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G |
STAT3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP |
Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT3 protein] |
CTD |
PMID:19635391 PMID:28086195 |
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NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
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G |
STK11 |
serine/threonine kinase 11 |
multiple interactions |
ISO |
[Thioctic Acid co-treated with Silicon] results in increased expression of STK11 mRNA |
CTD |
PMID:34252510 |
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NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431
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G |
SUMO1 |
small ubiquitin like modifier 1 |
increases expression |
EXP |
Thioctic Acid results in increased expression of SUMO1 protein |
CTD |
PMID:24975507 |
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NCBI chr 2:202,206,171...202,238,597
Ensembl chr 2:202,206,182...202,238,599
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G |
TFAM |
transcription factor A, mitochondrial |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Silicon results in decreased expression of TFAM mRNA] |
CTD |
PMID:34252510 |
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NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220
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G |
TGFA |
transforming growth factor alpha |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFA mRNA] |
CTD |
PMID:29233029 |
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NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
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G |
TGFB1 |
transforming growth factor beta 1 |
multiple interactions |
ISO |
Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA] Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of TGFB1 protein] |
CTD |
PMID:15309289 PMID:21251946 PMID:24704557 PMID:26276312 PMID:29760339 PMID:34252510 PMID:35187969 More...
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NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
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G |
TGFB1I1 |
transforming growth factor beta 1 induced transcript 1 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TGFB1I1 mRNA] |
CTD |
PMID:23608068 |
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NCBI chr16:31,472,152...31,477,960
Ensembl chr16:31,471,585...31,477,960
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G |
TGFB2 |
transforming growth factor beta 2 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TGFB2 mRNA; [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of TGFB2 mRNA |
CTD |
PMID:23830814 PMID:31068541 |
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NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
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G |
THRA |
thyroid hormone receptor alpha |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of THRA mRNA] |
CTD |
PMID:27260466 |
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NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867
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G |
TNF |
tumor necrosis factor |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TNF mRNA; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]]; Thioctic Acid affects the reaction [Paraquat affects the expression of TNF protein]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]] Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TNF mRNA] |
CTD |
PMID:15309289 PMID:23830814 PMID:25215149 PMID:26276312 PMID:29233029 PMID:29760339 PMID:35187969 More...
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NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
TNFRSF10C |
TNF receptor superfamily member 10c |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TNFRSF10B mRNA] |
CTD |
PMID:23830814 |
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NCBI chr 8:23,102,921...23,117,445
Ensembl chr 8:23,102,921...23,117,445
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G |
TNFSF10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of TNFSF10 mRNA |
CTD |
PMID:23830814 |
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NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
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G |
TNNI3 |
troponin I3, cardiac type |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] |
CTD |
PMID:21034734 |
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NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773
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G |
TP53 |
tumor protein p53 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Methotrexate results in increased expression of TP53 protein] |
CTD |
PMID:19900424 |
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NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
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G |
TRIB3 |
tribbles pseudokinase 3 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA]; Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of TRIB3 mRNA] |
CTD |
PMID:23608068 PMID:23892647 |
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NCBI chr20:380,760...397,559
Ensembl chr20:362,835...397,559
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G |
TXN |
thioredoxin |
multiple interactions |
ISO |
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of TXN1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA] |
CTD |
PMID:23830814 PMID:31068541 |
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NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
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G |
TXNRD1 |
thioredoxin reductase 1 |
increases reduction multiple interactions |
EXP ISO |
TXNRD1 protein results in increased reduction of Thioctic Acid Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein] |
CTD |
PMID:20810785 PMID:21172426 |
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NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
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G |
UCP2 |
uncoupling protein 2 |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA] |
CTD |
PMID:22327056 PMID:22464149 |
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NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843
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G |
VEGFA |
vascular endothelial growth factor A |
multiple interactions increases expression |
ISO |
Cyclosporine inhibits the reaction [Thioctic Acid results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased expression of VEGFA mRNA] Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of VEGFA mRNA] |
CTD |
PMID:11596663 PMID:22488045 PMID:26276312 |
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NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
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G |
WNT5A |
Wnt family member 5A |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of WNT5A protein] |
CTD |
PMID:37739047 |
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NCBI chr 3:55,465,715...55,505,263
Ensembl chr 3:55,465,715...55,490,539
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G |
XDH |
xanthine dehydrogenase |
multiple interactions |
ISO |
Thioctic Acid inhibits the reaction [Valproic Acid results in increased activity of XDH protein] |
CTD |
PMID:32662911 |
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NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
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