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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:heterocyclic fatty acid
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Accession:CHEBI:48847 term browser browse the term
Definition:Any fatty acid containing a ring composed of atoms including at least one heteroatom.
Synonyms:related_synonym: heterocyclic fatty acids



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(R)-lipoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions ISO [Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein CTD PMID:29128272 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ACADL acyl-CoA dehydrogenase long chain multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACADL mRNA] CTD PMID:22464149 NCBI chr 2:210,187,923...210,225,447
Ensembl chr 2:210,187,126...210,225,447
JBrowse link
G ACE angiotensin I converting enzyme multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE]
Thioctic Acid affects the reaction [Dietary Fats affects the activity of ACE protein]; Thioctic Acid affects the reaction [Dietary Fats affects the expression of ACE mRNA]
CTD PMID:26518973 PMID:27260466 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G ACHE acetylcholinesterase (Yt blood group) multiple interactions ISO [Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein]
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of ACHE protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]
CTD PMID:19669875 PMID:20663516 PMID:20730314 PMID:32911022 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACOX1 acyl-CoA oxidase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] CTD PMID:22464149 NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177
JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO Thioctic Acid inhibits the reaction [Mitogens results in increased expression of ACTA2 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of ACTA2 protein]
CTD PMID:21251946 PMID:24704557 PMID:29760339 PMID:34252510 PMID:35187969 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ADA adenosine deaminase multiple interactions ISO [Thioctic Acid co-treated with Valproic Acid] results in decreased activity of ADA protein CTD PMID:32662911 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]
Thioctic Acid results in increased expression of ADIPOQ mRNA; Thioctic Acid results in increased expression of ADIPOQ protein
CTD PMID:22664981 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AGT angiotensinogen multiple interactions ISO [Thioctic Acid co-treated with Dietary Fats] results in decreased expression of AGT mRNA CTD PMID:27260466 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G AGTR1 angiotensin II receptor type 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of AGTR1]
Thioctic Acid affects the reaction [Dietary Fats affects the expression of AGTR1A mRNA]
CTD PMID:26518973 PMID:27260466 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO Thioctic Acid results in decreased phosphorylation of AKT1 protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of AKT1 mRNA]
CTD PMID:21351249 PMID:27260466 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALAD aminolevulinate dehydratase multiple interactions ISO Thioctic Acid inhibits the reaction [gallium arsenide results in decreased activity of ALAD protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] CTD PMID:19798568 PMID:20026167 PMID:20584200 PMID:21783994 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G ALB albumin multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ALB protein]
ALB protein results in increased uptake of [Thioctic Acid binds to Gold]
CTD PMID:24704557 PMID:28433809 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G APLN apelin multiple interactions
increases secretion
increases expression
ISO acadesine inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA]; acadesine inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] CTD PMID:21461750 NCBI chr  X:129,645,259...129,654,956
Ensembl chr  X:129,645,259...129,654,956
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein]
CTD PMID:23892647 PMID:30605698 NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,683
JBrowse link
G ATF6 activating transcription factor 6 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF6 mRNA] CTD PMID:23892647 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574
JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in decreased expression of ATP1A2 mRNA] CTD PMID:34252510 NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591
JBrowse link
G ATP1B1 ATPase Na+/K+ transporting subunit beta 1 multiple interactions ISO Thioctic Acid affects the reaction [Dietary Fats affects the expression of ATP1B1 mRNA] CTD PMID:27260466 NCBI chr 1:169,106,690...169,132,719
Ensembl chr 1:169,105,697...169,310,992
JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO Thioctic Acid promotes the reaction [Dietary Fats results in decreased expression of ATP2A2 mRNA] CTD PMID:27260466 NCBI chr12:110,280,616...110,351,093
Ensembl chr12:110,280,756...110,351,093
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased localization of BAX protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of BAX protein]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BAX mRNA]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of BAX mRNA; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX protein]
CTD PMID:15735709 PMID:23830814 PMID:23892647 PMID:27544635 PMID:30605698 More... NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BBC3 mRNA] CTD PMID:23892647 NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCHE butyrylcholinesterase multiple interactions ISO [Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein]
Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of BCHE protein]
CTD PMID:20663516 PMID:32911022 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases response to substance
EXP
ISO
Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in decreased expression of BCL2 protein]; Thioctic Acid results in increased degradation of and results in decreased expression of BCL2 protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA]
Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 protein]
BCL2 protein results in decreased susceptibility to Thioctic Acid
CTD PMID:16990509 PMID:21600978 PMID:23830814 PMID:27260466 PMID:27544635 More... NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of BCL2L1 mRNA CTD PMID:23830814 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BRCA2 BRCA2 DNA repair associated multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of BRCA2 mRNA] CTD PMID:23608068 NCBI chr13:32,315,508...32,400,268
Ensembl chr13:32,315,086...32,400,268
JBrowse link
G C1QA complement C1q A chain decreases expression ISO Thioctic Acid results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,635,077...22,639,678
JBrowse link
G C4B complement C4B (Chido/Rodgers blood group) decreases expression ISO Thioctic Acid results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr 6:32,014,795...32,035,418
Ensembl chr 6:32,014,795...32,035,418
JBrowse link
G CALB2 calbindin 2 multiple interactions ISO Thioctic Acid affects the reaction [Propylthiouracil results in increased expression of CALB2 mRNA] CTD PMID:31068541 NCBI chr16:71,358,723...71,390,433
Ensembl chr16:71,358,713...71,390,436
JBrowse link
G CALM1 calmodulin 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of CALM1 mRNA] CTD PMID:26165643 NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268
JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of CAMK2A protein] CTD PMID:37739047 NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
increases activity
ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
Thioctic Acid results in increased expression of CASP3 protein modified form
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]
Thioctic Acid results in increased activity of CASP3 protein
[Ryanodine co-treated with Thioctic Acid] results in decreased activity of CASP3 protein; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP3 protein modified form]; Thioctic Acid inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]
CTD PMID:15909127 PMID:17079870 PMID:19951573 PMID:21062633 PMID:21763304 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP8 caspase 8 multiple interactions ISO
EXP
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]
CTD PMID:23830814 PMID:27544635 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
JBrowse link
G CASP9 caspase 9 increases activity
multiple interactions
EXP
ISO
Thioctic Acid results in increased activity of CASP9 protein
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CASP9 mRNA; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP9 protein modified form]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]
CTD PMID:16990509 PMID:19951573 PMID:23830814 PMID:27544635 PMID:30605698 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions
increases expression
increases activity
ISO
EXP
Thioctic Acid inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of CAT mRNA]
Thioctic Acid results in increased expression of CAT mRNA
[Paraquat co-treated with Thioctic Acid] results in increased expression of CAT mRNA
Thioctic Acid results in increased activity of CAT protein
[acetovanillone results in increased susceptibility to Thioctic Acid] inhibits the reaction [Mitogens results in decreased activity of CAT protein]; Succimer promotes the reaction [Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Valproic Acid results in decreased activity of CAT protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]]; Thioctic Acid promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]
CTD PMID:15998567 PMID:19368863 PMID:19699728 PMID:19715735 PMID:21763304 More... NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of CCL2 mRNA] CTD PMID:22488045 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
JBrowse link
G CCND1 cyclin D1 multiple interactions EXP Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein] CTD PMID:21600978 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CD36 CD36 molecule (CD36 blood group) multiple interactions EXP Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]] CTD PMID:21315065 NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CD86 CD86 molecule increases expression EXP Thioctic Acid results in increased expression of CD86 protein CTD PMID:19033392 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
JBrowse link
G CD8A CD8 subunit alpha multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA CTD PMID:23830814 NCBI chr 2:86,784,605...86,808,396
Ensembl chr 2:86,784,610...86,808,396
JBrowse link
G CDX4 caudal type homeobox 4 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of CDX4 mRNA] CTD PMID:23608068 NCBI chr  X:73,447,053...73,455,171
Ensembl chr  X:73,447,053...73,455,171
JBrowse link
G CHAT choline O-acetyltransferase multiple interactions ISO [Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein CTD PMID:19669875 NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942
JBrowse link
G CNTF ciliary neurotrophic factor multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone results in decreased activity of CNTF protein] CTD PMID:19635391 NCBI chr11:58,622,665...58,625,733
Ensembl chr11:58,622,665...58,625,733
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of COL1A1 mRNA; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL1A1 mRNA]
CTD PMID:21251946 PMID:23830814 PMID:34252510 PMID:35187969 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G COL3A1 collagen type III alpha 1 chain multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL3A1 mRNA] CTD PMID:34252510 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
JBrowse link
G COX4I1 cytochrome c oxidase subunit 4I1 multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in decreased expression of COX4I1 mRNA] CTD PMID:34252510 NCBI chr16:85,799,695...85,807,068
Ensembl chr16:85,798,633...85,807,068
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:22464149 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of CREB1 protein] CTD PMID:32061141 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CRP C-reactive protein multiple interactions ISO Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein] CTD PMID:26276312 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CRYAA crystallin alpha A multiple interactions ISO Thioctic Acid inhibits the reaction [naphthalene results in increased cleavage of CRYAA protein] CTD PMID:20597648 NCBI chr21:43,169,008...43,172,810
Ensembl chr21:43,169,008...43,172,805
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of CTNNB1 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of CTNNB1 protein] CTD PMID:34133789 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CTSD cathepsin D multiple interactions ISO Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] CTD PMID:12841641 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573
JBrowse link
G CTSS cathepsin S decreases expression ISO Thioctic Acid results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,079...150,765,957
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Thioctic Acid inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of CXCL8 mRNA] CTD PMID:30758914 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G CYBA cytochrome b-245 alpha chain multiple interactions ISO Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of CYBA mRNA] CTD PMID:35187969 NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB] CTD PMID:26518973 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461
JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO Thioctic Acid inhibits the reaction [Streptozocin affects the localization of CYCS protein] CTD PMID:19951573 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] CTD PMID:21932800 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions ISO
EXP
[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
CTD PMID:21932800 PMID:24120545 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions EXP Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 multiple interactions EXP Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions EXP Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 multiple interactions EXP Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO Thioctic Acid affects the reaction [cyanoginosin LR affects the expression of CYP2E1 protein] CTD PMID:32061150 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DAB1 DAB adaptor protein 1 multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of DAB1 mRNA CTD PMID:31068541 NCBI chr 1:56,994,778...58,546,726
Ensembl chr 1:56,994,778...58,546,734
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of DDIT3 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein]
CTD PMID:23892647 PMID:30605698 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DGAT2 diacylglycerol O-acyltransferase 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of DGAT2 mRNA] CTD PMID:22464149 NCBI chr11:75,768,778...75,801,534
Ensembl chr11:75,759,512...75,801,535
JBrowse link
G DIO1 iodothyronine deiodinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of DIO1 mRNA] CTD PMID:27260466 NCBI chr 1:53,894,187...53,911,086
Ensembl chr 1:53,891,239...53,911,086
JBrowse link
G DLD dihydrolipoamide dehydrogenase multiple interactions ISO [5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid] CTD PMID:21551353 NCBI chr 7:107,891,107...107,921,198
Ensembl chr 7:107,891,162...107,931,730
JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of DLG4 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of DLG4 protein] CTD PMID:34133789 NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,841
JBrowse link
G DNM1L dynamin 1 like multiple interactions
decreases expression
ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L mRNA]; Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L protein]
Thioctic Acid results in decreased expression of DNM1L mRNA
CTD PMID:37739047 NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650
JBrowse link
G DRD2 dopamine receptor D2 multiple interactions EXP Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]; Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein] CTD PMID:20730801 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2A protein] CTD PMID:23892647 NCBI chr 3:150,546,787...150,586,016
Ensembl chr 3:150,546,678...150,586,016
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form] CTD PMID:30605698 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516
JBrowse link
G FAS Fas cell surface death receptor multiple interactions EXP Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein] CTD PMID:27544635 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G FIS1 fission, mitochondrial 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of FIS1 mRNA] CTD PMID:37739047 NCBI chr 7:101,239,472...101,245,081
Ensembl chr 7:101,239,458...101,252,316
JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA] CTD PMID:23608068 NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145
JBrowse link
G FN1 fibronectin 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Diazinon results in decreased expression of FN1 protein]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA]
CTD PMID:32911022 PMID:35187969 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of FOS mRNA CTD PMID:31068541 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOXO3 forkhead box O3 decreases acetylation
multiple interactions
ISO Thioctic Acid results in decreased acetylation of FOXO3 protein
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein
CTD PMID:22327056 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G FRAS1 Fraser extracellular matrix complex subunit 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FRAS1 mRNA] CTD PMID:23608068 NCBI chr 4:78,057,323...78,544,269
Ensembl chr 4:78,057,323...78,544,269
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of FSHB protein] CTD PMID:20957662 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261
JBrowse link
G FZD2 frizzled class receptor 2 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of FZD2 protein] CTD PMID:34133789 NCBI chr17:44,557,484...44,561,262
Ensembl chr17:44,557,484...44,561,262
JBrowse link
G GAD1 glutamate decarboxylase 1 multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GAD1 mRNA CTD PMID:31068541 NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
multiple interactions
EXP
ISO
Thioctic Acid results in increased expression of GCLC mRNA
Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA]; Thioctic Acid results in increased expression of and results in increased activity of GCLC protein
Thioctic Acid inhibits the reaction [Silicon results in decreased expression of GCLC protein]
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein]
CTD PMID:16249512 PMID:17940886 PMID:26365678 PMID:27298056 PMID:32061141 More... NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression
multiple interactions
EXP
ISO
Thioctic Acid results in increased expression of GCLM mRNA; Thioctic Acid results in increased expression of GCLM protein
Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM mRNA]; Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM protein]
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM protein]
CTD PMID:16249512 PMID:26365678 PMID:32061141 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GFAP glial fibrillary acidic protein decreases expression ISO Thioctic Acid results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GGT1 gamma-glutamyltransferase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein] CTD PMID:24704557 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,594,811...24,629,005
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium affects the localization of GJA1 protein]; Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of GJA1 mRNA]
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]
CTD PMID:26165643 PMID:27260466 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GLS glutaminase multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GLS protein] CTD PMID:32061141 NCBI chr 2:190,880,821...190,965,552
Ensembl chr 2:190,880,821...190,965,552
JBrowse link
G GNRHR gonadotropin releasing hormone receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GNRHR mRNA] CTD PMID:28070105 NCBI chr 4:67,737,118...67,754,388
Ensembl chr 4:67,737,118...67,754,388
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GPT protein]
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of GPT protein]
CTD PMID:24704557 PMID:37739047 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GPX1 glutathione peroxidase 1 increases expression
multiple interactions
EXP
ISO
Thioctic Acid results in increased expression of GPX1 mRNA
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GPX1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GPX1 mRNA]
CTD PMID:23649336 PMID:32061141 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
JBrowse link
G GPX2 glutathione peroxidase 2 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GPX2 mRNA CTD PMID:23830814 NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746
JBrowse link
G GPX3 glutathione peroxidase 3 increases expression
multiple interactions
EXP Thioctic Acid results in increased expression of GPX3 mRNA
[Paraquat co-treated with Thioctic Acid] results in increased expression of GPX3 mRNA
CTD PMID:23649336 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988
JBrowse link
G GPX5 glutathione peroxidase 5 increases expression EXP Thioctic Acid results in increased expression of GPX5 mRNA CTD PMID:23649336 NCBI chr 6:28,525,881...28,534,955
Ensembl chr 6:28,525,881...28,534,955
JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 protein] CTD PMID:32061141 NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756
JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GRIN2A mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A protein] CTD PMID:31068541 PMID:32061141 NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928
JBrowse link
G GSK3B glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
ISO Thioctic Acid results in increased phosphorylation of GSK3B protein
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of GSK3B protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of GSK3B protein]
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]
CTD PMID:19879292 PMID:27260466 PMID:34133789 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions
increases expression
ISO
EXP
Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of GSR protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GSR protein]
Thioctic Acid inhibits the reaction [cyanoginosin LR results in decreased activity of GSR protein]
Thioctic Acid results in increased expression of GSR mRNA
CTD PMID:19699728 PMID:22623521 PMID:23649336 PMID:27581792 PMID:32061150 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSS glutathione synthetase multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of GSS protein] CTD PMID:32061141 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027
JBrowse link
G GSTM1 glutathione S-transferase mu 1 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA
[Dietary Fats co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA
CTD PMID:18367378 PMID:23830814 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions
increases expression
ISO [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; Thioctic Acid results in increased expression of and results in increased activity of GSTP1 protein
Thioctic Acid results in increased expression of GSTP1 mRNA
CTD PMID:20237067 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G GUSB glucuronidase beta multiple interactions ISO Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GUSB protein] CTD PMID:19699728 NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 multiple interactions EXP [Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein CTD PMID:28433809 NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
EXP
ISO
[Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of HMOX1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein]
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 protein]
Thioctic Acid results in increased expression of HMOX1 mRNA; Thioctic Acid results in increased expression of HMOX1 protein
Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of HMOX1 mRNA]
CTD PMID:19033392 PMID:21315065 PMID:22488045 PMID:23649336 PMID:23942037 More... NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HS1BP3 HCLS1 binding protein 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of HS1BP3 mRNA] CTD PMID:23608068 NCBI chr 2:20,553,861...20,651,098
Ensembl chr 2:20,560,448...20,651,130
JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A multiple interactions ISO Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA] CTD PMID:28880400 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HSPA5 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]
CTD PMID:23892647 PMID:30605698 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA] CTD PMID:28880400 NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874
JBrowse link
G IL10 interleukin 10 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of IL10]; Thioctic Acid promotes the reaction [Carrageenan results in increased expression of IL10 mRNA] CTD PMID:19735303 PMID:26518973 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1A interleukin 1 alpha multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of IL1A mRNA CTD PMID:31068541 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO
EXP
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL1B mRNA; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL1B]
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]
CTD PMID:23830814 PMID:24975507 PMID:26518973 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL2 protein] CTD PMID:21195065 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL22RA2 interleukin 22 receptor subunit alpha 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of IL22RA2 mRNA] CTD PMID:23608068 NCBI chr 6:137,143,820...137,173,644
Ensembl chr 6:137,143,820...137,173,648
JBrowse link
G IL4 interleukin 4 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL4 mRNA CTD PMID:23830814 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of IL6 mRNA]
[Thioctic Acid binds to Gold] which results in increased expression of IL6 protein
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL6]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]]
CTD PMID:22488045 PMID:26518973 PMID:28433809 PMID:29233029 PMID:29760339 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS insulin multiple interactions EXP Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased secretion of INS1 protein]] CTD PMID:21461750 PMID:29760339 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G IRF1 interferon regulatory factor 1 multiple interactions EXP Thioctic Acid results in increased sumoylation of and results in decreased activity of IRF1 protein CTD PMID:24975507 NCBI chr 5:132,481,609...132,490,773
Ensembl chr 5:132,440,440...132,508,719
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
increases activity
ISO [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]
Thioctic Acid results in increased expression of JUN protein
Thioctic Acid results in increased activity of JUN protein
CTD PMID:20237067 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G KEAP1 kelch like ECH associated protein 1 increases expression
multiple interactions
EXP
ISO
Thioctic Acid results in increased expression of KEAP1 protein
Thioctic Acid inhibits the reaction [Silicon results in increased expression of KEAP1 protein]
CTD PMID:19033392 PMID:34252510 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G LDHC lactate dehydrogenase C multiple interactions ISO Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of LDHC protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased expression of LDHC protein] CTD PMID:21195065 PMID:27581792 NCBI chr11:18,412,318...18,452,063
Ensembl chr11:18,412,318...18,452,063
JBrowse link
G LEP leptin decreases secretion
decreases expression
ISO Thioctic Acid results in decreased secretion of LEP protein
Thioctic Acid results in decreased expression of LEP mRNA; Thioctic Acid results in decreased expression of LEP protein
CTD PMID:21351249 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of LHB protein]; Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LHB mRNA] CTD PMID:20957662 PMID:28070105 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091
JBrowse link
G LIPE lipase E, hormone sensitive type multiple interactions
increases phosphorylation
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Thioctic Acid results in increased phosphorylation of LIPE protein] CTD PMID:22941773 NCBI chr19:42,401,514...42,427,388
Ensembl chr19:42,401,514...42,427,388
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 affects activity
multiple interactions
ISO Thioctic Acid affects the activity of MAPK1 protein
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK1 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK1 protein]
CTD PMID:15909127 PMID:21251946 PMID:32061141 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK14 mRNA CTD PMID:23830814 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK3 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK3 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK3 protein] CTD PMID:21251946 PMID:23830814 PMID:32061141 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK8 mRNA CTD PMID:23830814 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPT microtubule associated protein tau multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of MAPT protein] CTD PMID:34133789 NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334
JBrowse link
G MFF mitochondrial fission factor multiple interactions
decreases expression
ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFF mRNA]
Thioctic Acid results in decreased expression of MFF mRNA
CTD PMID:37739047 NCBI chr 2:227,325,251...227,357,836
Ensembl chr 2:227,325,151...227,357,833
JBrowse link
G MFN2 mitofusin 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFN2 mRNA] CTD PMID:37739047 NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211
JBrowse link
G MIR21 microRNA 21 multiple interactions ISO Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA] CTD PMID:26276312 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
JBrowse link
G MIR210 microRNA 210 multiple interactions ISO [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]] CTD PMID:26276312 NCBI chr11:568,089...568,198
Ensembl chr11:568,089...568,198
JBrowse link
G MMP12 matrix metallopeptidase 12 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA CTD PMID:23830814 NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982
JBrowse link
G MMP13 matrix metallopeptidase 13 multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA]
CTD PMID:24975507 PMID:29233029 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of MMP2 mRNA CTD PMID:23830814 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP3 matrix metallopeptidase 3 multiple interactions EXP Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] CTD PMID:24975507 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
JBrowse link
G MSR1 macrophage scavenger receptor 1 multiple interactions EXP Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]] CTD PMID:21315065 NCBI chr 8:16,107,881...16,192,651
Ensembl chr 8:16,107,878...16,567,490
JBrowse link
G MT1X metallothionein 1X multiple interactions ISO [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MT1 mRNA CTD PMID:18367378 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G MVD mevalonate diphosphate decarboxylase multiple interactions ISO [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MVD mRNA CTD PMID:18367378 NCBI chr16:88,651,940...88,663,091
Ensembl chr16:88,651,935...88,663,161
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of MYC protein] CTD PMID:21600978 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of NCF1] CTD PMID:26518973 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization
increases expression
increases activity
decreases expression
EXP
ISO
[Paraquat co-treated with Thioctic Acid] results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NFE2L2 mRNA]; Thioctic Acid promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thioctic Acid results in increased expression of and affects the localization of NFE2L2 protein
Thioctic Acid affects the localization of NFE2L2 protein
Thioctic Acid results in increased expression of NFE2L2 mRNA; Thioctic Acid results in increased expression of NFE2L2 protein
Thioctic Acid results in increased activity of NFE2L2 protein
[Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]
Thioctic Acid results in decreased expression of NFE2L2 mRNA; Thioctic Acid results in decreased expression of NFE2L2 protein
[Thioctic Acid co-treated with cyanoginosin LR] results in increased expression of NFE2L2 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of NFE2L2 protein]
CTD PMID:17197552 PMID:18258206 PMID:20237067 PMID:22488045 PMID:23649336 More... NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein]
[Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA
CTD PMID:21600978 PMID:31068541 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of NFKBIA protein] CTD PMID:34133789 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
JBrowse link
G NGFR nerve growth factor receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TNFRSF10B mRNA] CTD PMID:23608068 NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of NOS2]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]
CTD PMID:15453632 PMID:21763304 PMID:29233029 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] CTD PMID:27260466 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G NOX1 NADPH oxidase 1 multiple interactions ISO acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]] CTD PMID:29760339 NCBI chr  X:100,843,324...100,874,359
Ensembl chr  X:100,843,324...100,874,359
JBrowse link
G NOX4 NADPH oxidase 4 multiple interactions ISO acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA]
CTD PMID:29760339 PMID:35187969 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
multiple interactions
EXP
ISO
Thioctic Acid results in increased activity of NQO1 protein
Thioctic Acid results in increased expression of NQO1 mRNA; Thioctic Acid results in increased expression of NQO1 protein
[Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 protein]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA]
CTD PMID:12180195 PMID:17940886 PMID:19033392 PMID:23649336 PMID:23830814 More... NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of OPA1 mRNA] CTD PMID:37739047 NCBI chr 3:193,593,208...193,697,811
Ensembl chr 3:193,593,144...193,697,811
JBrowse link
G OTX2 orthodenticle homeobox 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA] CTD PMID:31068541 NCBI chr14:56,799,905...56,810,479
Ensembl chr14:56,799,905...56,816,693
JBrowse link
G PAH phenylalanine hydroxylase decreases expression ISO Thioctic Acid results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
JBrowse link
G PCDHB6 protocadherin beta 6 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of PCDHB6 mRNA] CTD PMID:23608068 NCBI chr 5:141,150,057...141,153,287
Ensembl chr 5:141,150,057...141,153,287
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of PCNA protein] CTD PMID:21251946 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PINK1 PTEN induced kinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PINK1 mRNA] CTD PMID:37739047 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511
JBrowse link
G PLAAT3 phospholipase A and acyltransferase 3 decreases activity
decreases expression
ISO Thioctic Acid results in decreased activity of PLAAT3 protein
Thioctic Acid results in decreased expression of PLAAT3 mRNA
CTD PMID:22941773 NCBI chr11:63,574,462...63,616,927
Ensembl chr11:63,573,195...63,616,883
JBrowse link
G PLIN1 perilipin 1 increases phosphorylation ISO Thioctic Acid results in increased phosphorylation of PLIN1 protein CTD PMID:22941773 NCBI chr15:89,664,367...89,679,367
Ensembl chr15:89,664,367...89,679,427
JBrowse link
G POR cytochrome p450 oxidoreductase multiple interactions
decreases activity
ISO
EXP
[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; [Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
CTD PMID:16391466 PMID:21932800 PMID:24120545 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA] CTD PMID:22464149 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO [Thioctic Acid co-treated with Dietary Fats] results in increased expression of PPARG mRNA CTD PMID:22464149 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions
decreases expression
increases expression
EXP
ISO
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein
Thioctic Acid results in decreased expression of PPARGC1A protein
[Thioctic Acid co-treated with Silicon] results in increased expression of PPARGC1A protein; Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of PPARGC1A mRNA]
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]
Thioctic Acid results in increased expression of PPARGC1A protein
CTD PMID:20414966 PMID:22464149 PMID:34252510 PMID:37739047 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PPARGC1B PPARG coactivator 1 beta multiple interactions
decreases acetylation
ISO [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA]
Thioctic Acid results in decreased acetylation of PPARGC1B protein
CTD PMID:22327056 PMID:22464149 NCBI chr 5:149,730,310...149,857,959
Ensembl chr 5:149,730,298...149,855,022
JBrowse link
G PRDX3 peroxiredoxin 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRDX3 mRNA] CTD PMID:37739047 NCBI chr10:119,167,720...119,178,812
Ensembl chr10:119,167,720...119,178,812
JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO [Thioctic Acid co-treated with Silicon] results in increased expression of PRKAA2 mRNA CTD PMID:34252510 NCBI chr 1:56,645,314...56,715,335
Ensembl chr 1:56,645,314...56,715,335
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRKN mRNA] CTD PMID:37739047 NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775
JBrowse link
G PSEN1 presenilin 1 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of PSEN1 protein] CTD PMID:34133789 NCBI chr14:73,136,417...73,223,691
Ensembl chr14:73,136,418...73,223,691
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]]; Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]] CTD PMID:19735303 PMID:23830814 PMID:26276312 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation
ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of RELA protein]
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of RELA protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA mRNA]
Thioctic Acid results in decreased phosphorylation of RELA protein
CTD PMID:22488045 PMID:29233029 PMID:34133789 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RELN reelin multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of RELN mRNA CTD PMID:31068541 NCBI chr 7:103,471,789...103,989,658
Ensembl chr 7:103,471,381...103,989,658
JBrowse link
G S100B S100 calcium binding protein B multiple interactions ISO [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein] CTD PMID:23880158 NCBI chr21:46,598,604...46,605,082
Ensembl chr21:46,598,604...46,605,208
JBrowse link
G SEMA5A semaphorin 5A multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of SEMA5A mRNA] CTD PMID:23608068 NCBI chr 5:9,035,033...9,546,075
Ensembl chr 5:9,035,033...9,546,075
JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in increased expression of SERPINE1 protein] CTD PMID:34252510 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SERPINH1 serpin family H member 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA] CTD PMID:24704557 NCBI chr11:75,562,253...75,572,783
Ensembl chr11:75,562,056...75,572,783
JBrowse link
G SFTPA1 surfactant protein A1 multiple interactions ISO Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPA1 mRNA] CTD PMID:25215149 NCBI chr10:79,610,939...79,615,455
Ensembl chr10:79,610,939...79,615,455
JBrowse link
G SFTPB surfactant protein B multiple interactions ISO Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPB mRNA] CTD PMID:25215149 NCBI chr 2:85,657,307...85,668,741
Ensembl chr 2:85,657,314...85,668,741
JBrowse link
G SIRT1 sirtuin 1 increases expression
multiple interactions
ISO Thioctic Acid results in increased expression of SIRT1 protein
Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT1 mRNA]
Thioctic Acid results in increased expression of SIRT1 mRNA
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA]
CTD PMID:22327056 PMID:37739047 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SIRT3 sirtuin 3 multiple interactions
increases expression
ISO [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 mRNA]
Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT3 mRNA]
Thioctic Acid results in increased expression of SIRT3 protein
CTD PMID:22327056 PMID:37739047 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931
JBrowse link
G SLC12A2 solute carrier family 12 member 2 multiple interactions
affects activity
ISO [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] promotes the reaction [Thioctic Acid results in decreased activity of Ammonia]
Thioctic Acid affects the activity of SLC12A2 protein
CTD PMID:23880158 NCBI chr 5:128,083,766...128,189,677
Ensembl chr 5:128,083,766...128,189,677
JBrowse link
G SLC1A1 solute carrier family 1 member 1 multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC1A1 mRNA] CTD PMID:32061141 NCBI chr 9:4,490,468...4,587,469
Ensembl chr 9:4,490,468...4,587,469
JBrowse link
G SLC38A2 solute carrier family 38 member 2 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA] CTD PMID:23892647 NCBI chr12:46,358,188...46,372,773
Ensembl chr12:46,358,188...46,372,773
JBrowse link
G SLC5A6 solute carrier family 5 member 6 increases transport
multiple interactions
EXP
ISO
SLC5A6 results in increased transport of Thioctic Acid
Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Biotin]; Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
Sodium affects the reaction [SLC5A6 results in increased transport of Thioctic Acid]
CTD PMID:9516450 PMID:10329687 NCBI chr 2:27,199,587...27,212,787
Ensembl chr 2:27,199,587...27,212,958
JBrowse link
G SLC7A11 solute carrier family 7 member 11 multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC7A11 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC7A11 mRNA] CTD PMID:32061141 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SMAD2 SMAD family member 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] CTD PMID:35187969 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146
JBrowse link
G SMAD3 SMAD family member 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] CTD PMID:35187969 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173
JBrowse link
G SNCA synuclein alpha multiple interactions EXP [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Thioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:20414966 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of SOD1] CTD PMID:15804455 PMID:26518973 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
increases activity
ISO Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein]
[Thioctic Acid co-treated with Dietary Fats] results in decreased expression of SOD2 mRNA; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of SOD2 mRNA]
Thioctic Acid results in increased activity of SOD2 protein
CTD PMID:15804455 PMID:19951573 PMID:22327056 PMID:27260466 PMID:34252510 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SP1 Sp1 transcription factor multiple interactions ISO Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein CTD PMID:21351249 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:22464149 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions ISO Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STAR mRNA] CTD PMID:28070105 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP Thioctic Acid affects the reaction [Zinc deficiency affects the phosphorylation of STAT1 protein]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT1 protein] CTD PMID:19635391 PMID:28086195 NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT3 protein] CTD PMID:19635391 PMID:28086195 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
G STK11 serine/threonine kinase 11 multiple interactions ISO [Thioctic Acid co-treated with Silicon] results in increased expression of STK11 mRNA CTD PMID:34252510 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431
JBrowse link
G SUMO1 small ubiquitin like modifier 1 increases expression EXP Thioctic Acid results in increased expression of SUMO1 protein CTD PMID:24975507 NCBI chr 2:202,206,171...202,238,597
Ensembl chr 2:202,206,182...202,238,599
JBrowse link
G TFAM transcription factor A, mitochondrial multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in decreased expression of TFAM mRNA] CTD PMID:34252510 NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220
JBrowse link
G TGFA transforming growth factor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFA mRNA] CTD PMID:29233029 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of TGFB1 protein]
CTD PMID:15309289 PMID:21251946 PMID:24704557 PMID:26276312 PMID:29760339 More... NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TGFB1I1 transforming growth factor beta 1 induced transcript 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TGFB1I1 mRNA] CTD PMID:23608068 NCBI chr16:31,472,152...31,477,960
Ensembl chr16:31,471,585...31,477,960
JBrowse link
G TGFB2 transforming growth factor beta 2 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TGFB2 mRNA; [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of TGFB2 mRNA CTD PMID:23830814 PMID:31068541 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G THRA thyroid hormone receptor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of THRA mRNA] CTD PMID:27260466 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TNF mRNA; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]]; Thioctic Acid affects the reaction [Paraquat affects the expression of TNF protein]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]
CTD PMID:15309289 PMID:23830814 PMID:25215149 PMID:26276312 PMID:29233029 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF10C TNF receptor superfamily member 10c multiple interactions ISO Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TNFRSF10B mRNA] CTD PMID:23830814 NCBI chr 8:23,102,921...23,117,445
Ensembl chr 8:23,102,921...23,117,445
JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of TNFSF10 mRNA CTD PMID:23830814 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
JBrowse link
G TNNI3 troponin I3, cardiac type multiple interactions ISO Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] CTD PMID:21034734 NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773
JBrowse link
G TP53 tumor protein p53 multiple interactions ISO Thioctic Acid inhibits the reaction [Methotrexate results in increased expression of TP53 protein] CTD PMID:19900424 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRIB3 tribbles pseudokinase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA]; Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of TRIB3 mRNA] CTD PMID:23608068 PMID:23892647 NCBI chr20:380,760...397,559
Ensembl chr20:362,835...397,559
JBrowse link
G TXN thioredoxin multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of TXN1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA] CTD PMID:23830814 PMID:31068541 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases reduction
multiple interactions
EXP
ISO
TXNRD1 protein results in increased reduction of Thioctic Acid
Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]
CTD PMID:20810785 PMID:21172426 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G UCP2 uncoupling protein 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA] CTD PMID:22327056 PMID:22464149 NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions
increases expression
ISO Cyclosporine inhibits the reaction [Thioctic Acid results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased expression of VEGFA mRNA]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of VEGFA mRNA]
CTD PMID:11596663 PMID:22488045 PMID:26276312 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G WNT5A Wnt family member 5A multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of WNT5A protein] CTD PMID:37739047 NCBI chr 3:55,465,715...55,505,263
Ensembl chr 3:55,465,715...55,490,539
JBrowse link
G XDH xanthine dehydrogenase multiple interactions ISO Thioctic Acid inhibits the reaction [Valproic Acid results in increased activity of XDH protein] CTD PMID:32662911 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
14,15-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme decreases activity ISO 14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased activity of ACE protein CTD PMID:27428043 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G ACE2 angiotensin converting enzyme 2 multiple interactions ISO 14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased expression of ACE2 protein] CTD PMID:27428043 NCBI chr  X:15,518,197...15,607,211
Ensembl chr  X:15,494,566...15,607,236
JBrowse link
G AGT angiotensinogen multiple interactions
decreases expression
increases cleavage
ISO 14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form]
14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased expression of AGT protein modified form
[14,15-epoxy-5,8,11-eicosatrienoic acid analog results in increased cleavage of AGT protein modified form] which results in increased abundance of angiotensin I (1-7)
CTD PMID:27428043 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases phosphorylation EXP 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of AKT1 protein CTD PMID:16286479 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 increases chemical synthesis EXP CYP2C8 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid CTD PMID:12675279 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases chemical synthesis
multiple interactions
EXP CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid
Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD PMID:12675279 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases chemical synthesis
multiple interactions
EXP CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD PMID:12675279 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G EPHX2 epoxide hydrolase 2 multiple interactions
increases abundance
ISO [Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid; [Mercuric Chloride results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
EPHX2 gene mutant form results in increased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
CTD PMID:19896470 PMID:22680237 PMID:24472606 NCBI chr 8:27,491,143...27,548,626
Ensembl chr 8:27,490,781...27,545,564
JBrowse link
G FGF2 fibroblast growth factor 2 increases expression EXP 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased expression of FGF2 protein CTD PMID:16286479 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK1 protein CTD PMID:19464254 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK3 protein CTD PMID:19464254 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 increases phosphorylation EXP 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of RPS6KB1 protein CTD PMID:16286479 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
decreases secretion
EXP 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [TGFB1 protein results in decreased secretion of 14,15-epoxy-5,8,11-eicosatrienoic acid] CTD PMID:28694203 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
5,6-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
increases chemical synthesis
EXP Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid] CTD PMID:12675279 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G EPHX2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 5,6-epoxy-8,11,14-eicosatrienoic acid CTD PMID:19896470 NCBI chr 8:27,491,143...27,548,626
Ensembl chr 8:27,490,781...27,545,564
JBrowse link
8,9-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases chemical synthesis
multiple interactions
EXP CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid
Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]
CTD PMID:12675279 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases chemical synthesis
multiple interactions
EXP CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]
CTD PMID:12675279 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G EPHX1 epoxide hydrolase 1 affects hydrolysis ISO EPHX1 protein affects the hydrolysis of 8,9-epoxyeicosatrienoic acid CTD PMID:28975360 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563
JBrowse link
G EPHX2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 8,9-epoxyeicosatrienoic acid CTD PMID:19896470 NCBI chr 8:27,491,143...27,548,626
Ensembl chr 8:27,490,781...27,545,564
JBrowse link
hepoxilin A3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 increases export ISO ABCC2 protein results in increased export of 8-hydroxy-11,12-epoxyeicosa-5,9,14-trienoic acid CTD PMID:30102254 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594
JBrowse link
leukotriene A4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase increases chemical synthesis EXP ALOX5 protein results in increased chemical synthesis of Leukotriene A4 CTD PMID:18295198 NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G LTA4H leukotriene A4 hydrolase multiple interactions
increases hydrolysis
EXP cyclohexene inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Oxygen inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Piperonyl Butoxide inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; propanethiol inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4] CTD PMID:2827578 NCBI chr12:96,000,753...96,043,520
Ensembl chr12:96,000,753...96,043,520
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 decreases activity ISO Leukotriene A4 results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259
JBrowse link
lipoamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP lipoamide inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein] CTD PMID:18258206 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases reduction EXP TXNRD1 protein results in increased reduction of lipoamide CTD PMID:21172426 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G TXNRD2 thioredoxin reductase 2 increases reduction EXP TXNRD2 protein results in increased reduction of lipoamide CTD PMID:21172426 NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820
JBrowse link
lipoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions ISO [Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein CTD PMID:29128272 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ACADL acyl-CoA dehydrogenase long chain multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACADL mRNA] CTD PMID:22464149 NCBI chr 2:210,187,923...210,225,447
Ensembl chr 2:210,187,126...210,225,447
JBrowse link
G ACE angiotensin I converting enzyme multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of ACE]
Thioctic Acid affects the reaction [Dietary Fats affects the activity of ACE protein]; Thioctic Acid affects the reaction [Dietary Fats affects the expression of ACE mRNA]
CTD PMID:26518973 PMID:27260466 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G ACHE acetylcholinesterase (Yt blood group) multiple interactions ISO [Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein]
[Thioctic Acid co-treated with Pilocarpine] results in increased activity of ACHE protein; Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of ACHE protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ACHE protein]
CTD PMID:19669875 PMID:20663516 PMID:20730314 PMID:32911022 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACOX1 acyl-CoA oxidase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA] CTD PMID:22464149 NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177
JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO Thioctic Acid inhibits the reaction [Mitogens results in increased expression of ACTA2 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of ACTA2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of ACTA2 protein]
CTD PMID:21251946 PMID:24704557 PMID:29760339 PMID:34252510 PMID:35187969 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ADA adenosine deaminase multiple interactions ISO [Thioctic Acid co-treated with Valproic Acid] results in decreased activity of ADA protein CTD PMID:32662911 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]
Thioctic Acid results in increased expression of ADIPOQ mRNA; Thioctic Acid results in increased expression of ADIPOQ protein
CTD PMID:22664981 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AGT angiotensinogen multiple interactions ISO [Thioctic Acid co-treated with Dietary Fats] results in decreased expression of AGT mRNA CTD PMID:27260466 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G AGTR1 angiotensin II receptor type 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of AGTR1]
Thioctic Acid affects the reaction [Dietary Fats affects the expression of AGTR1A mRNA]
CTD PMID:26518973 PMID:27260466 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO Thioctic Acid results in decreased phosphorylation of AKT1 protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of AKT1 mRNA]
CTD PMID:21351249 PMID:27260466 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALAD aminolevulinate dehydratase multiple interactions ISO Thioctic Acid inhibits the reaction [gallium arsenide results in decreased activity of ALAD protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in decreased expression of ALAD protein] CTD PMID:19798568 PMID:20026167 PMID:20584200 PMID:21783994 NCBI chr 9:113,386,312...113,401,284
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G ALB albumin multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of ALB protein]
ALB protein results in increased uptake of [Thioctic Acid binds to Gold]
CTD PMID:24704557 PMID:28433809 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G APLN apelin multiple interactions
increases secretion
increases expression
ISO acadesine inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA]; acadesine inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] CTD PMID:21461750 NCBI chr  X:129,645,259...129,654,956
Ensembl chr  X:129,645,259...129,654,956
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein]
CTD PMID:23892647 PMID:30605698 NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,683
JBrowse link
G ATF6 activating transcription factor 6 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of and results in increased cleavage of ATF6 protein]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF6 mRNA] CTD PMID:23892647 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574
JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in decreased expression of ATP1A2 mRNA] CTD PMID:34252510 NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591
JBrowse link
G ATP1B1 ATPase Na+/K+ transporting subunit beta 1 multiple interactions ISO Thioctic Acid affects the reaction [Dietary Fats affects the expression of ATP1B1 mRNA] CTD PMID:27260466 NCBI chr 1:169,106,690...169,132,719
Ensembl chr 1:169,105,697...169,310,992
JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO Thioctic Acid promotes the reaction [Dietary Fats results in decreased expression of ATP2A2 mRNA] CTD PMID:27260466 NCBI chr12:110,280,616...110,351,093
Ensembl chr12:110,280,756...110,351,093
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased localization of BAX protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of BAX protein]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BAX mRNA]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of BAX mRNA; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of BAX protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of BAX protein]
CTD PMID:15735709 PMID:23830814 PMID:23892647 PMID:27544635 PMID:30605698 More... NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of BBC3 mRNA] CTD PMID:23892647 NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCHE butyrylcholinesterase multiple interactions ISO [Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein; Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein]
Thioctic Acid inhibits the reaction [Diazinon results in decreased activity of BCHE protein]
CTD PMID:20663516 PMID:32911022 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases response to substance
EXP
ISO
Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [Zinc Oxide analog results in decreased expression of BCL2 protein]; Thioctic Acid results in increased degradation of and results in decreased expression of BCL2 protein
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA]
Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of BCL2 protein]
BCL2 protein results in decreased susceptibility to Thioctic Acid
CTD PMID:16990509 PMID:21600978 PMID:23830814 PMID:27260466 PMID:27544635 More... NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of BCL2L1 mRNA CTD PMID:23830814 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BRCA2 BRCA2 DNA repair associated multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of BRCA2 mRNA] CTD PMID:23608068 NCBI chr13:32,315,508...32,400,268
Ensembl chr13:32,315,086...32,400,268
JBrowse link
G C1QA complement C1q A chain decreases expression ISO Thioctic Acid results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,635,077...22,639,678
JBrowse link
G C4B complement C4B (Chido/Rodgers blood group) decreases expression ISO Thioctic Acid results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr 6:32,014,795...32,035,418
Ensembl chr 6:32,014,795...32,035,418
JBrowse link
G CALB2 calbindin 2 multiple interactions ISO Thioctic Acid affects the reaction [Propylthiouracil results in increased expression of CALB2 mRNA] CTD PMID:31068541 NCBI chr16:71,358,723...71,390,433
Ensembl chr16:71,358,713...71,390,436
JBrowse link
G CALM1 calmodulin 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of CALM1 mRNA] CTD PMID:26165643 NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268
JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of CAMK2A protein] CTD PMID:37739047 NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
increases activity
ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
Thioctic Acid results in increased expression of CASP3 protein modified form
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP3 protein]
Thioctic Acid results in increased activity of CASP3 protein
[Ryanodine co-treated with Thioctic Acid] results in decreased activity of CASP3 protein; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP3 protein modified form]; Thioctic Acid inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein]; Thioctic Acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in increased expression of CASP3 mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]
CTD PMID:15909127 PMID:17079870 PMID:19951573 PMID:21062633 PMID:21763304 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP8 caspase 8 multiple interactions ISO
EXP
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of CASP8 mRNA
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP8 protein]
CTD PMID:23830814 PMID:27544635 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
JBrowse link
G CASP9 caspase 9 increases activity
multiple interactions
EXP
ISO
Thioctic Acid results in increased activity of CASP9 protein
Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased activity of CASP9 protein]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CASP9 mRNA; Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of CASP9 protein modified form]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]
CTD PMID:16990509 PMID:19951573 PMID:23830814 PMID:27544635 PMID:30605698 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions
increases expression
increases activity
ISO
EXP
Thioctic Acid inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA]; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of CAT mRNA]
Thioctic Acid results in increased expression of CAT mRNA
[Paraquat co-treated with Thioctic Acid] results in increased expression of CAT mRNA
Thioctic Acid results in increased activity of CAT protein
[acetovanillone results in increased susceptibility to Thioctic Acid] inhibits the reaction [Mitogens results in decreased activity of CAT protein]; Succimer promotes the reaction [Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Thioctic Acid inhibits the reaction [Valproic Acid results in decreased activity of CAT protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]]; Thioctic Acid promotes the reaction [Succimer inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]]
CTD PMID:15998567 PMID:19368863 PMID:19699728 PMID:19715735 PMID:21763304 More... NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of CCL2 mRNA] CTD PMID:22488045 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
JBrowse link
G CCND1 cyclin D1 multiple interactions EXP Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of CCND1 protein] CTD PMID:21600978 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CD36 CD36 molecule (CD36 blood group) multiple interactions EXP Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD36 mRNA]] CTD PMID:21315065 NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CD86 CD86 molecule increases expression EXP Thioctic Acid results in increased expression of CD86 protein CTD PMID:19033392 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
JBrowse link
G CD8A CD8 subunit alpha multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA CTD PMID:23830814 NCBI chr 2:86,784,605...86,808,396
Ensembl chr 2:86,784,610...86,808,396
JBrowse link
G CDX4 caudal type homeobox 4 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of CDX4 mRNA] CTD PMID:23608068 NCBI chr  X:73,447,053...73,455,171
Ensembl chr  X:73,447,053...73,455,171
JBrowse link
G CHAT choline O-acetyltransferase multiple interactions ISO [Thioctic Acid co-treated with Pilocarpine] results in increased activity of CHAT protein CTD PMID:19669875 NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942
JBrowse link
G CNTF ciliary neurotrophic factor multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of CNTF protein]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone results in decreased activity of CNTF protein] CTD PMID:19635391 NCBI chr11:58,622,665...58,625,733
Ensembl chr11:58,622,665...58,625,733
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of COL1A1 mRNA; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of COL1A1 mRNA]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL1A1 mRNA]
CTD PMID:21251946 PMID:23830814 PMID:34252510 PMID:35187969 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G COL3A1 collagen type III alpha 1 chain multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in increased expression of COL3A1 mRNA] CTD PMID:34252510 NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746
JBrowse link
G COX4I1 cytochrome c oxidase subunit 4I1 multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in decreased expression of COX4I1 mRNA] CTD PMID:34252510 NCBI chr16:85,799,695...85,807,068
Ensembl chr16:85,798,633...85,807,068
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] CTD PMID:22464149 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of CREB1 protein] CTD PMID:32061141 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CRP C-reactive protein multiple interactions ISO Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein]]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of CRP protein] CTD PMID:26276312 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
JBrowse link
G CRYAA crystallin alpha A multiple interactions ISO Thioctic Acid inhibits the reaction [naphthalene results in increased cleavage of CRYAA protein] CTD PMID:20597648 NCBI chr21:43,169,008...43,172,810
Ensembl chr21:43,169,008...43,172,805
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of CTNNB1 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of CTNNB1 protein] CTD PMID:34133789 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CTSD cathepsin D multiple interactions ISO Thioctic Acid inhibits the reaction [Doxorubicin results in decreased activity of CTSD protein] CTD PMID:12841641 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573
JBrowse link
G CTSS cathepsin S decreases expression ISO Thioctic Acid results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 1:150,730,188...150,765,778
Ensembl chr 1:150,730,079...150,765,957
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Thioctic Acid inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of CXCL8 mRNA] CTD PMID:30758914 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G CYBA cytochrome b-245 alpha chain multiple interactions ISO Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of CYBA mRNA] CTD PMID:35187969 NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB] CTD PMID:26518973 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461
JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO Thioctic Acid inhibits the reaction [Streptozocin affects the localization of CYCS protein] CTD PMID:19951573 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO [CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]] CTD PMID:21932800 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions ISO
EXP
[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
CTD PMID:21932800 PMID:24120545 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions EXP Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 multiple interactions EXP Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions EXP Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 multiple interactions EXP Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO Thioctic Acid affects the reaction [cyanoginosin LR affects the expression of CYP2E1 protein] CTD PMID:32061150 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DAB1 DAB adaptor protein 1 multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of DAB1 mRNA CTD PMID:31068541 NCBI chr 1:56,994,778...58,546,726
Ensembl chr 1:56,994,778...58,546,734
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of DDIT3 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein]
CTD PMID:23892647 PMID:30605698 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DGAT2 diacylglycerol O-acyltransferase 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of DGAT2 mRNA] CTD PMID:22464149 NCBI chr11:75,768,778...75,801,534
Ensembl chr11:75,759,512...75,801,535
JBrowse link
G DIO1 iodothyronine deiodinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of DIO1 mRNA] CTD PMID:27260466 NCBI chr 1:53,894,187...53,911,086
Ensembl chr 1:53,891,239...53,911,086
JBrowse link
G DLD dihydrolipoamide dehydrogenase multiple interactions ISO [5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid] CTD PMID:21551353 NCBI chr 7:107,891,107...107,921,198
Ensembl chr 7:107,891,162...107,931,730
JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of DLG4 protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of DLG4 protein] CTD PMID:34133789 NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,841
JBrowse link
G DNM1L dynamin 1 like decreases expression
multiple interactions
ISO Thioctic Acid results in decreased expression of DNM1L mRNA
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L mRNA]; Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of DNM1L protein]
CTD PMID:37739047 NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650
JBrowse link
G DRD2 dopamine receptor D2 multiple interactions EXP Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]; Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein] CTD PMID:20730801 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2A protein] CTD PMID:23892647 NCBI chr 3:150,546,787...150,586,016
Ensembl chr 3:150,546,678...150,586,016
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of EIF2S1 protein modified form] CTD PMID:30605698 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516
JBrowse link
G FAS Fas cell surface death receptor multiple interactions EXP Thioctic Acid inhibits the reaction [Zinc Oxide analog results in increased expression of FAS protein] CTD PMID:27544635 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G FIS1 fission, mitochondrial 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of FIS1 mRNA] CTD PMID:37739047 NCBI chr 7:101,239,472...101,245,081
Ensembl chr 7:101,239,458...101,252,316
JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA] CTD PMID:23608068 NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145
JBrowse link
G FN1 fibronectin 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Diazinon results in decreased expression of FN1 protein]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA]
CTD PMID:32911022 PMID:35187969 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of FOS mRNA CTD PMID:31068541 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOXO3 forkhead box O3 decreases acetylation
multiple interactions
ISO Thioctic Acid results in decreased acetylation of FOXO3 protein
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein
CTD PMID:22327056 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G FRAS1 Fraser extracellular matrix complex subunit 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FRAS1 mRNA] CTD PMID:23608068 NCBI chr 4:78,057,323...78,544,269
Ensembl chr 4:78,057,323...78,544,269
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of FSHB protein] CTD PMID:20957662 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261
JBrowse link
G FZD2 frizzled class receptor 2 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of FZD2 protein] CTD PMID:34133789 NCBI chr17:44,557,484...44,561,262
Ensembl chr17:44,557,484...44,561,262
JBrowse link
G GAD1 glutamate decarboxylase 1 multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GAD1 mRNA CTD PMID:31068541 NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
multiple interactions
EXP
ISO
Thioctic Acid results in increased expression of GCLC mRNA
Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA]; Thioctic Acid results in increased expression of and results in increased activity of GCLC protein
Thioctic Acid inhibits the reaction [Silicon results in decreased expression of GCLC protein]
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLC protein]
CTD PMID:16249512 PMID:17940886 PMID:26365678 PMID:27298056 PMID:32061141 More... NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit increases expression
multiple interactions
EXP
ISO
Thioctic Acid results in increased expression of GCLM mRNA; Thioctic Acid results in increased expression of GCLM protein
Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM mRNA]; Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM protein]
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM protein]
CTD PMID:16249512 PMID:26365678 PMID:32061141 NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GFAP glial fibrillary acidic protein decreases expression ISO Thioctic Acid results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GGT1 gamma-glutamyltransferase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GGT1 protein] CTD PMID:24704557 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,594,811...24,629,005
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium affects the localization of GJA1 protein]; Thioctic Acid inhibits the reaction [Cadmium results in decreased expression of GJA1 mRNA]
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GJA1 mRNA]
CTD PMID:26165643 PMID:27260466 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GLS glutaminase multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased activity of GLS protein] CTD PMID:32061141 NCBI chr 2:190,880,821...190,965,552
Ensembl chr 2:190,880,821...190,965,552
JBrowse link
G GNRHR gonadotropin releasing hormone receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GNRHR mRNA] CTD PMID:28070105 NCBI chr 4:67,737,118...67,754,388
Ensembl chr 4:67,737,118...67,754,388
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of GPT protein]
Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of GPT protein]
CTD PMID:24704557 PMID:37739047 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GPX1 glutathione peroxidase 1 increases expression
multiple interactions
EXP
ISO
Thioctic Acid results in increased expression of GPX1 mRNA
Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GPX1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GPX1 mRNA]
CTD PMID:23649336 PMID:32061141 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
JBrowse link
G GPX2 glutathione peroxidase 2 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GPX2 mRNA CTD PMID:23830814 NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746
JBrowse link
G GPX3 glutathione peroxidase 3 increases expression
multiple interactions
EXP Thioctic Acid results in increased expression of GPX3 mRNA
[Paraquat co-treated with Thioctic Acid] results in increased expression of GPX3 mRNA
CTD PMID:23649336 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988
JBrowse link
G GPX5 glutathione peroxidase 5 increases expression EXP Thioctic Acid results in increased expression of GPX5 mRNA CTD PMID:23649336 NCBI chr 6:28,525,881...28,534,955
Ensembl chr 6:28,525,881...28,534,955
JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN1 protein] CTD PMID:32061141 NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756
JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of GRIN2A mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GRIN2A protein] CTD PMID:31068541 PMID:32061141 NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928
JBrowse link
G GSK3B glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
ISO Thioctic Acid results in increased phosphorylation of GSK3B protein
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased phosphorylation of GSK3B protein]; Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of GSK3B protein]
Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]
CTD PMID:19879292 PMID:27260466 PMID:34133789 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions
increases expression
ISO
EXP
Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of GSR protein]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GSR protein]
Thioctic Acid inhibits the reaction [cyanoginosin LR results in decreased activity of GSR protein]
Thioctic Acid results in increased expression of GSR mRNA
CTD PMID:19699728 PMID:22623521 PMID:23649336 PMID:27581792 PMID:32061150 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSS glutathione synthetase multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased activity of GSS protein] CTD PMID:32061141 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027
JBrowse link
G GSTM1 glutathione S-transferase mu 1 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA
[Dietary Fats co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNA
CTD PMID:18367378 PMID:23830814 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions
increases expression
ISO [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; Thioctic Acid results in increased expression of and results in increased activity of GSTP1 protein
Thioctic Acid results in increased expression of GSTP1 mRNA
CTD PMID:20237067 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G GUSB glucuronidase beta multiple interactions ISO Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased activity of GUSB protein] CTD PMID:19699728 NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 multiple interactions EXP [Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein CTD PMID:28433809 NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
EXP
ISO
[Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of HMOX1 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of HMOX1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of HMOX1 protein]
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of HMOX1 protein]
Thioctic Acid results in increased expression of HMOX1 mRNA; Thioctic Acid results in increased expression of HMOX1 protein
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA]; Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of HMOX1 mRNA]
CTD PMID:19033392 PMID:21315065 PMID:22488045 PMID:23649336 PMID:23942037 More... NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HS1BP3 HCLS1 binding protein 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of HS1BP3 mRNA] CTD PMID:23608068 NCBI chr 2:20,553,861...20,651,098
Ensembl chr 2:20,560,448...20,651,130
JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A multiple interactions ISO Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA] CTD PMID:28880400 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HSPA5 protein]
Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]
CTD PMID:23892647 PMID:30605698 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA] CTD PMID:28880400 NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874
JBrowse link
G IL10 interleukin 10 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of IL10]; Thioctic Acid promotes the reaction [Carrageenan results in increased expression of IL10 mRNA] CTD PMID:19735303 PMID:26518973 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1A interleukin 1 alpha multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of IL1A mRNA CTD PMID:31068541 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO
EXP
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL1B mRNA; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL1B]
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]
CTD PMID:23830814 PMID:24975507 PMID:26518973 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased secretion of IL2 protein] CTD PMID:21195065 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL22RA2 interleukin 22 receptor subunit alpha 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of IL22RA2 mRNA] CTD PMID:23608068 NCBI chr 6:137,143,820...137,173,644
Ensembl chr 6:137,143,820...137,173,648
JBrowse link
G IL4 interleukin 4 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of IL4 mRNA CTD PMID:23830814 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 multiple interactions ISO
EXP
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of IL6 mRNA]
[Thioctic Acid binds to Gold] which results in increased expression of IL6 protein
acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IL6]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]]
CTD PMID:22488045 PMID:26518973 PMID:28433809 PMID:29233029 PMID:29760339 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS insulin multiple interactions EXP Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; Thioctic Acid inhibits the reaction [Mitogens results in increased secretion of INS1 protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased secretion of INS1 protein]] CTD PMID:21461750 PMID:29760339 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209
JBrowse link
G IRF1 interferon regulatory factor 1 multiple interactions EXP Thioctic Acid results in increased sumoylation of and results in decreased activity of IRF1 protein CTD PMID:24975507 NCBI chr 5:132,481,609...132,490,773
Ensembl chr 5:132,440,440...132,508,719
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
increases activity
ISO [Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]
Thioctic Acid results in increased expression of JUN protein
Thioctic Acid results in increased activity of JUN protein
CTD PMID:20237067 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G KEAP1 kelch like ECH associated protein 1 increases expression
multiple interactions
EXP
ISO
Thioctic Acid results in increased expression of KEAP1 protein
Thioctic Acid inhibits the reaction [Silicon results in increased expression of KEAP1 protein]
CTD PMID:19033392 PMID:34252510 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G LDHC lactate dehydrogenase C multiple interactions ISO Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of LDHC protein]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in decreased expression of LDHC protein] CTD PMID:21195065 PMID:27581792 NCBI chr11:18,412,318...18,452,063
Ensembl chr11:18,412,318...18,452,063
JBrowse link
G LEP leptin decreases secretion
decreases expression
ISO Thioctic Acid results in decreased secretion of LEP protein
Thioctic Acid results in decreased expression of LEP mRNA; Thioctic Acid results in decreased expression of LEP protein
CTD PMID:21351249 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions ISO Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of LHB protein]; Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LHB mRNA] CTD PMID:20957662 PMID:28070105 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091
JBrowse link
G LIPE lipase E, hormone sensitive type multiple interactions
increases phosphorylation
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Thioctic Acid results in increased phosphorylation of LIPE protein] CTD PMID:22941773 NCBI chr19:42,401,514...42,427,388
Ensembl chr19:42,401,514...42,427,388
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 affects activity
multiple interactions
ISO Thioctic Acid affects the activity of MAPK1 protein
Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK1 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK1 protein]
CTD PMID:15909127 PMID:21251946 PMID:32061141 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK14 mRNA CTD PMID:23830814 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK3 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased phosphorylation of MAPK3 protein]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK3 protein] CTD PMID:21251946 PMID:23830814 PMID:32061141 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK8 mRNA CTD PMID:23830814 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPT microtubule associated protein tau multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased phosphorylation of MAPT protein] CTD PMID:34133789 NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334
JBrowse link
G MFF mitochondrial fission factor multiple interactions
decreases expression
ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFF mRNA]
Thioctic Acid results in decreased expression of MFF mRNA
CTD PMID:37739047 NCBI chr 2:227,325,251...227,357,836
Ensembl chr 2:227,325,151...227,357,833
JBrowse link
G MFN2 mitofusin 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of MFN2 mRNA] CTD PMID:37739047 NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211
JBrowse link
G MIR21 microRNA 21 multiple interactions ISO Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA]]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of MIR21 mRNA] CTD PMID:26276312 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337
JBrowse link
G MIR210 microRNA 210 multiple interactions ISO [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of MIR210 mRNA]] CTD PMID:26276312 NCBI chr11:568,089...568,198
Ensembl chr11:568,089...568,198
JBrowse link
G MMP12 matrix metallopeptidase 12 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA CTD PMID:23830814 NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982
JBrowse link
G MMP13 matrix metallopeptidase 13 multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA]
CTD PMID:24975507 PMID:29233029 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of MMP2 mRNA CTD PMID:23830814 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP3 matrix metallopeptidase 3 multiple interactions EXP Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein] CTD PMID:24975507 NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
JBrowse link
G MSR1 macrophage scavenger receptor 1 multiple interactions EXP Thioctic Acid inhibits the reaction [arsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA]] CTD PMID:21315065 NCBI chr 8:16,107,881...16,192,651
Ensembl chr 8:16,107,878...16,567,490
JBrowse link
G MT1X metallothionein 1X multiple interactions ISO [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MT1 mRNA CTD PMID:18367378 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G MVD mevalonate diphosphate decarboxylase multiple interactions ISO [Dietary Fats co-treated with Thioctic Acid] results in decreased expression of MVD mRNA CTD PMID:18367378 NCBI chr16:88,651,940...88,663,091
Ensembl chr16:88,651,935...88,663,161
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Thioctic Acid inhibits the reaction [Zinc deficiency results in decreased expression of MYC protein] CTD PMID:21600978 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of NCF1] CTD PMID:26518973 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization
increases expression
increases activity
decreases expression
EXP
ISO
[Paraquat co-treated with Thioctic Acid] results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid inhibits the reaction [Acrolein results in decreased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Polychlorinated Biphenyls analog results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which affects the localization of NFE2L2 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NFE2L2 mRNA]; Thioctic Acid promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thioctic Acid results in increased expression of and affects the localization of NFE2L2 protein
Thioctic Acid affects the localization of NFE2L2 protein
Thioctic Acid results in increased expression of NFE2L2 mRNA; Thioctic Acid results in increased expression of NFE2L2 protein
Thioctic Acid results in increased activity of NFE2L2 protein
[Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]
Thioctic Acid results in decreased expression of NFE2L2 mRNA; Thioctic Acid results in decreased expression of NFE2L2 protein
[Thioctic Acid co-treated with cyanoginosin LR] results in increased expression of NFE2L2 protein; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of NFE2L2 protein]
CTD PMID:17197552 PMID:18258206 PMID:20237067 PMID:22488045 PMID:23649336 More... NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP
ISO
Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein]
[Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNA
CTD PMID:21600978 PMID:31068541 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in decreased expression of NFKBIA protein] CTD PMID:34133789 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
JBrowse link
G NGFR nerve growth factor receptor multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TNFRSF10B mRNA] CTD PMID:23608068 NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of NOS2]; Thioctic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]
CTD PMID:15453632 PMID:21763304 PMID:29233029 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA] CTD PMID:27260466 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G NOX1 NADPH oxidase 1 multiple interactions ISO acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]] CTD PMID:29760339 NCBI chr  X:100,843,324...100,874,359
Ensembl chr  X:100,843,324...100,874,359
JBrowse link
G NOX4 NADPH oxidase 4 multiple interactions ISO acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA]
CTD PMID:29760339 PMID:35187969 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
multiple interactions
EXP
ISO
Thioctic Acid results in increased activity of NQO1 protein
Thioctic Acid results in increased expression of NQO1 mRNA; Thioctic Acid results in increased expression of NQO1 protein
[Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; [Paraquat co-treated with Thioctic Acid] results in increased expression of NQO1 protein; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Thioctic Acid results in increased expression of NQO1 protein]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 mRNA]; Thioctic Acid promotes the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NQO1 protein]
[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of NQO1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of NQO1 mRNA]
CTD PMID:12180195 PMID:17940886 PMID:19033392 PMID:23649336 PMID:23830814 More... NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of OPA1 mRNA] CTD PMID:37739047 NCBI chr 3:193,593,208...193,697,811
Ensembl chr 3:193,593,144...193,697,811
JBrowse link
G OTX2 orthodenticle homeobox 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of OTX2 mRNA] CTD PMID:31068541 NCBI chr14:56,799,905...56,810,479
Ensembl chr14:56,799,905...56,816,693
JBrowse link
G PAH phenylalanine hydroxylase decreases expression ISO Thioctic Acid results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
JBrowse link
G PCDHB6 protocadherin beta 6 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of PCDHB6 mRNA] CTD PMID:23608068 NCBI chr 5:141,150,057...141,153,287
Ensembl chr 5:141,150,057...141,153,287
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of PCNA protein] CTD PMID:21251946 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PINK1 PTEN induced kinase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PINK1 mRNA] CTD PMID:37739047 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511
JBrowse link
G PLAAT3 phospholipase A and acyltransferase 3 decreases activity
decreases expression
ISO Thioctic Acid results in decreased activity of PLAAT3 protein
Thioctic Acid results in decreased expression of PLAAT3 mRNA
CTD PMID:22941773 NCBI chr11:63,574,462...63,616,927
Ensembl chr11:63,573,195...63,616,883
JBrowse link
G PLIN1 perilipin 1 increases phosphorylation ISO Thioctic Acid results in increased phosphorylation of PLIN1 protein CTD PMID:22941773 NCBI chr15:89,664,367...89,679,367
Ensembl chr15:89,664,367...89,679,427
JBrowse link
G POR cytochrome p450 oxidoreductase multiple interactions
decreases activity
ISO
EXP
[CYP1A1 protein co-treated with CYP1A2 protein] affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]; [Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; CYP1A1 protein affects the reaction [[Thioctic Acid results in decreased activity of POR protein] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]]
Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
CTD PMID:16391466 PMID:21932800 PMID:24120545 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA] CTD PMID:22464149 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO [Thioctic Acid co-treated with Dietary Fats] results in increased expression of PPARG mRNA CTD PMID:22464149 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions
decreases expression
increases expression
EXP
ISO
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein
Thioctic Acid results in decreased expression of PPARGC1A protein
[Thioctic Acid co-treated with Silicon] results in increased expression of PPARGC1A protein; Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of PPARGC1A mRNA]
Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]
Thioctic Acid results in increased expression of PPARGC1A protein
CTD PMID:20414966 PMID:22464149 PMID:34252510 PMID:37739047 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PPARGC1B PPARG coactivator 1 beta multiple interactions
decreases acetylation
ISO [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1B mRNA]
Thioctic Acid results in decreased acetylation of PPARGC1B protein
CTD PMID:22327056 PMID:22464149 NCBI chr 5:149,730,310...149,857,959
Ensembl chr 5:149,730,298...149,855,022
JBrowse link
G PRDX3 peroxiredoxin 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRDX3 mRNA] CTD PMID:37739047 NCBI chr10:119,167,720...119,178,812
Ensembl chr10:119,167,720...119,178,812
JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO [Thioctic Acid co-treated with Silicon] results in increased expression of PRKAA2 mRNA CTD PMID:34252510 NCBI chr 1:56,645,314...56,715,335
Ensembl chr 1:56,645,314...56,715,335
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PRKN mRNA] CTD PMID:37739047 NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775
JBrowse link
G PSEN1 presenilin 1 multiple interactions ISO Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of PSEN1 protein] CTD PMID:34133789 NCBI chr14:73,136,417...73,223,691
Ensembl chr14:73,136,418...73,223,691
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Cyclosporine co-treated with Thioctic Acid] promotes the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]]; Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Carrageenan results in increased expression of PTGS2 mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 mRNA]] CTD PMID:19735303 PMID:23830814 PMID:26276312 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation
ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of RELA protein]
Thioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of RELA protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA mRNA]
Thioctic Acid results in decreased phosphorylation of RELA protein
CTD PMID:22488045 PMID:29233029 PMID:34133789 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RELN reelin multiple interactions ISO [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of RELN mRNA CTD PMID:31068541 NCBI chr 7:103,471,789...103,989,658
Ensembl chr 7:103,471,381...103,989,658
JBrowse link
G S100B S100 calcium binding protein B multiple interactions ISO [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein] CTD PMID:23880158 NCBI chr21:46,598,604...46,605,082
Ensembl chr21:46,598,604...46,605,208
JBrowse link
G SEMA5A semaphorin 5A multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of SEMA5A mRNA] CTD PMID:23608068 NCBI chr 5:9,035,033...9,546,075
Ensembl chr 5:9,035,033...9,546,075
JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in increased expression of SERPINE1 protein] CTD PMID:34252510 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SERPINH1 serpin family H member 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of SERPINH1 mRNA] CTD PMID:24704557 NCBI chr11:75,562,253...75,572,783
Ensembl chr11:75,562,056...75,572,783
JBrowse link
G SFTPA1 surfactant protein A1 multiple interactions ISO Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPA1 mRNA] CTD PMID:25215149 NCBI chr10:79,610,939...79,615,455
Ensembl chr10:79,610,939...79,615,455
JBrowse link
G SFTPB surfactant protein B multiple interactions ISO Thioctic Acid affects the reaction [Paraquat affects the expression of SFTPB mRNA] CTD PMID:25215149 NCBI chr 2:85,657,307...85,668,741
Ensembl chr 2:85,657,314...85,668,741
JBrowse link
G SIRT1 sirtuin 1 increases expression
multiple interactions
ISO Thioctic Acid results in increased expression of SIRT1 protein
Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT1 mRNA]
Thioctic Acid results in increased expression of SIRT1 mRNA
[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA]
CTD PMID:22327056 PMID:37739047 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SIRT3 sirtuin 3 multiple interactions
increases expression
ISO [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 mRNA]
Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT3 mRNA]
Thioctic Acid results in increased expression of SIRT3 protein
CTD PMID:22327056 PMID:37739047 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931
JBrowse link
G SLC12A2 solute carrier family 12 member 2 multiple interactions
affects activity
ISO [Furosemide results in decreased activity of SLC12A2 protein] affects the reaction [Thioctic Acid inhibits the reaction [Ammonia results in increased secretion of S100B protein]]; [Furosemide results in decreased activity of SLC12A2 protein] promotes the reaction [Thioctic Acid results in decreased activity of Ammonia]
Thioctic Acid affects the activity of SLC12A2 protein
CTD PMID:23880158 NCBI chr 5:128,083,766...128,189,677
Ensembl chr 5:128,083,766...128,189,677
JBrowse link
G SLC1A1 solute carrier family 1 member 1 multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A1 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC1A1 mRNA] CTD PMID:32061141 NCBI chr 9:4,490,468...4,587,469
Ensembl chr 9:4,490,468...4,587,469
JBrowse link
G SLC38A2 solute carrier family 38 member 2 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of SLC38A2 mRNA] CTD PMID:23892647 NCBI chr12:46,358,188...46,372,773
Ensembl chr12:46,358,188...46,372,773
JBrowse link
G SLC5A6 solute carrier family 5 member 6 increases transport
multiple interactions
EXP
ISO
SLC5A6 results in increased transport of Thioctic Acid
Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Biotin]; Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
Sodium affects the reaction [SLC5A6 results in increased transport of Thioctic Acid]
CTD PMID:9516450 PMID:10329687 NCBI chr 2:27,199,587...27,212,787
Ensembl chr 2:27,199,587...27,212,958
JBrowse link
G SLC7A11 solute carrier family 7 member 11 multiple interactions ISO Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of SLC7A11 protein]; Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of SLC7A11 mRNA] CTD PMID:32061141 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SMAD2 SMAD family member 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD2 protein] CTD PMID:35187969 NCBI chr18:47,808,957...47,930,872
Ensembl chr18:47,808,957...47,931,146
JBrowse link
G SMAD3 SMAD family member 3 multiple interactions ISO Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] CTD PMID:35187969 NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173
JBrowse link
G SNCA synuclein alpha multiple interactions EXP [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Thioctic Acid inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:20414966 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein]; Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of SOD1] CTD PMID:15804455 PMID:26518973 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
increases activity
ISO Thioctic Acid inhibits the reaction [sodium arsenite results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein]
[Thioctic Acid co-treated with Dietary Fats] results in decreased expression of SOD2 mRNA; Thioctic Acid inhibits the reaction [Silicon results in decreased activity of SOD2 protein]; Thioctic Acid inhibits the reaction [Silicon results in decreased expression of SOD2 mRNA]
Thioctic Acid results in increased activity of SOD2 protein
CTD PMID:15804455 PMID:19951573 PMID:22327056 PMID:27260466 PMID:34252510 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SP1 Sp1 transcription factor multiple interactions ISO Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein CTD PMID:21351249 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:22464149 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions ISO Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of STAR mRNA] CTD PMID:28070105 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP Thioctic Acid affects the reaction [Zinc deficiency affects the phosphorylation of STAT1 protein]; Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT1 protein] CTD PMID:19635391 PMID:28086195 NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]; Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of STAT3 protein] CTD PMID:19635391 PMID:28086195 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
JBrowse link
G STK11 serine/threonine kinase 11 multiple interactions ISO [Thioctic Acid co-treated with Silicon] results in increased expression of STK11 mRNA CTD PMID:34252510 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431
JBrowse link
G SUMO1 small ubiquitin like modifier 1 increases expression EXP Thioctic Acid results in increased expression of SUMO1 protein CTD PMID:24975507 NCBI chr 2:202,206,171...202,238,597
Ensembl chr 2:202,206,182...202,238,599
JBrowse link
G TFAM transcription factor A, mitochondrial multiple interactions ISO Thioctic Acid inhibits the reaction [Silicon results in decreased expression of TFAM mRNA] CTD PMID:34252510 NCBI chr10:58,385,410...58,399,220
Ensembl chr10:58,385,345...58,399,220
JBrowse link
G TGFA transforming growth factor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFA mRNA] CTD PMID:29233029 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]; Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Thioctic Acid inhibits the reaction [Silicon results in increased expression of TGFB1 protein]
CTD PMID:15309289 PMID:21251946 PMID:24704557 PMID:26276312 PMID:29760339 More... NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TGFB1I1 transforming growth factor beta 1 induced transcript 1 multiple interactions ISO Thioctic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of TGFB1I1 mRNA] CTD PMID:23608068 NCBI chr16:31,472,152...31,477,960
Ensembl chr16:31,471,585...31,477,960
JBrowse link
G TGFB2 transforming growth factor beta 2 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TGFB2 mRNA; [Thioctic Acid co-treated with Propylthiouracil] results in increased expression of TGFB2 mRNA CTD PMID:23830814 PMID:31068541 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G THRA thyroid hormone receptor alpha multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in increased expression of THRA mRNA] CTD PMID:27260466 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] affects the expression of TNF mRNA; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]]; Cyclosporine inhibits the reaction [Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]]; Thioctic Acid affects the reaction [Paraquat affects the expression of TNF protein]; Thioctic Acid inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]]
Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]
CTD PMID:15309289 PMID:23830814 PMID:25215149 PMID:26276312 PMID:29233029 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF10C TNF receptor superfamily member 10c multiple interactions ISO Thioctic Acid inhibits the reaction [[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of TNFRSF10B mRNA] CTD PMID:23830814 NCBI chr 8:23,102,921...23,117,445
Ensembl chr 8:23,102,921...23,117,445
JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in decreased expression of TNFSF10 mRNA CTD PMID:23830814 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
JBrowse link
G TNNI3 troponin I3, cardiac type multiple interactions ISO Thioctic Acid inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] CTD PMID:21034734 NCBI chr19:55,151,767...55,157,732
Ensembl chr19:55,151,767...55,157,773
JBrowse link
G TP53 tumor protein p53 multiple interactions ISO Thioctic Acid inhibits the reaction [Methotrexate results in increased expression of TP53 protein] CTD PMID:19900424 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRIB3 tribbles pseudokinase 3 multiple interactions ISO Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of TRIB3 mRNA]; Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of TRIB3 mRNA] CTD PMID:23608068 PMID:23892647 NCBI chr20:380,760...397,559
Ensembl chr20:362,835...397,559
JBrowse link
G TXN thioredoxin multiple interactions ISO [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of TXN1 mRNA; Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA] CTD PMID:23830814 PMID:31068541 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases reduction
multiple interactions
EXP
ISO
TXNRD1 protein results in increased reduction of Thioctic Acid
Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]
CTD PMID:20810785 PMID:21172426 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G UCP2 uncoupling protein 2 multiple interactions ISO Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA] CTD PMID:22327056 PMID:22464149 NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,672...73,982,843
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions
increases expression
ISO Cyclosporine inhibits the reaction [Thioctic Acid results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Cyclosporine results in increased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased expression of VEGFA mRNA]
Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of VEGFA mRNA]
CTD PMID:11596663 PMID:22488045 PMID:26276312 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G WNT5A Wnt family member 5A multiple interactions ISO Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of WNT5A protein] CTD PMID:37739047 NCBI chr 3:55,465,715...55,505,263
Ensembl chr 3:55,465,715...55,490,539
JBrowse link
G XDH xanthine dehydrogenase multiple interactions ISO Thioctic Acid inhibits the reaction [Valproic Acid results in increased activity of XDH protein] CTD PMID:32662911 NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    chemical entity 26019
      molecular entity 25997
        polyatomic entity 25882
          molecule 25273
            cyclic compound 24280
              heterocyclic compound 22322
                heterocyclic fatty acid 226
                  (2E,11Z)-5-[5-(Methylthio)-4-penten-2-ynyl]-2-furanacrolein 0
                  (2E,11Z)-Wyerone acid 0
                  (2S)-1-hydroxy-3-\{[9-(3-methyl-5-pentylfuran-2-yl)nonanoyl]oxy\}propan-2-yl 13-(3,4-dimethyl-5-pentylfuran-2-yl)tridecanoate 0
                  (2S)-2-\{[11-(3,4-dimethyl-5-pentylfuran-2-yl)undecanoyl]oxy\}-3-hydroxypropyl 13-(3-methyl-5-pentylfuran-2-yl)tridecanoate 0
                  (2S,3R,4S)-4-[(2S,7S,8R,9S)-2-[(5S)-5-ethyl-5-[(3S,5R)-5-[(3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2-oxanyl]-3-methyl-2-oxolanyl]-2-oxolanyl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoic acid 0
                  (5R,7S,8S)-Communiol A 0
                  (5R,7S,8S)-Communiol B 0
                  (E)-4-[(1R,5R,6R)-3-[(1E,3E)-hepta-1,3-dienyl]-5-hydroxy-4-(hydroxymethyl)-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methylbut-2-enoic acid 0
                  (E)-4-[(1R,5R,6R)-3-heptyl-5-hydroxy-4-(hydroxymethyl)-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methylbut-2-enoic acid 0
                  (E)-4-[(1R,5R,6R)-4-(acetyloxymethyl)-3-[(E)-hept-1-enyl]-5-hydroxy-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methylbut-2-enoic acid 0
                  (E)-4-[(1R,5R,6R)-5-hydroxy-4-(hydroxymethyl)-2-oxo-3-[(E)-5-oxohept-1-enyl]-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methylbut-2-enoic acid 0
                  (E)-4-[(1S,2S,6S)-3-[(E)-hept-1-enyl]-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methylbut-2-enoic acid 0
                  (E)-4-[(1S,2S,6S)-4-[chloro(methoxy)methyl]-2-hydroxy-3-(2-hydroxyheptyl)-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methylbut-2-enoic acid 0
                  (E)-4-[(1aR,7aR,7bR)-3-[(E)-hept-1-enyl]-6,6-dimethyl-2-oxo-7a,7b-dihydro-4H-oxireno[2,3-h][1,3]benzodioxin-1a-yl]-2-methylbut-2-enoic acid 0
                  (R)-lipoic acid + 216
                  (S)-lipoic acid + 0
                  1-(5-(1,2-dihydroxypropyl)-furan-2-yl)-pentan-1-one 0
                  1-(5-(1-hydroxypentyl)furan-2-yl)propane-1,2-diol 0
                  1-(5-(1-methoxypent-4-en-1-yl)furan-2-yl)propane-1,2-diol 0
                  1-(5-(1-methoxypentyl)furan-2-yl)propane-1,2-diol 0
                  1-(5-(2-hydroxybutyl)furan-2-yl)-3-methoxybutan-2-OL 0
                  1-(5-(2-hydroxypropanoyl)-furan-2-yl)-pentan-3-one 0
                  10-(3,4-dimethyl-5-pentylfuran-2-yl)-decanoic acid 0
                  2-(5-((2Z,5Z,8Z,11Z)-tetradeca-2,5,8,11-tetraen-1-yl)furan-2-yl)-ethanoic acid 0
                  2-(5-((3Z,13Z)-eicosa-3,13-dien-1-yl)furan-2-yl)-ethanoic acid 0
                  2-(5-hexadecylfuran-2-yl)-acetic acid 0
                  2-Butyl-5-[2-(4-hydroxy-3-methoxyphenyl)ethyl]furan 0
                  2-Demethylmonensin A 0
                  2-Demethylmonensin B 0
                  2-Hexyl-5-[2-(4-hydroxy-3-methoxyphenyl)ethyl]furan 0
                  2-Hydroxy-3-(10-methyl-2,7-dioxooxecan-5-yl)sulfanylpropanoic acid 0
                  2-carboxyethyl-5-furanpentanoic acid 0
                  2-cyano-N-(2,4-dichlorophenyl)-3-[5-(2-methylcyclopropyl)-2-furanyl]-2-propenamide 0
                  2-hydroxy-1-(5-(1-hydroxypentyl)-furan-2-yl)-propan-1-one 0
                  26-deoxymonensin A 0
                  3,4-Dimethyl-5-pentyl-2-furanheptanoic acid 0
                  3,4-Dimethyl-5-pentyl-2-furanpentanoic acid 0
                  3,4-Dimethyl-5-pentyl-2-furanpropanoic acid 0
                  3,4-dimethyl-5-carboxybutyl-2-furanpentanoic acid 0
                  3,4-dimethyl-5-carboxyethyl-2-furanacrylic acid 0
                  3,4-dimethyl-5-carboxyethyl-2-furanbutanoic acid 0
                  3,4-dimethyl-5-carboxyethyl-2-furanhexanoic acid 0
                  3,4-dimethyl-5-carboxyethyl-2-furanpentanoic acid 0
                  3,4-dimethyl-5-carboxyethyl-2-furanpropanoic acid 0
                  3,4-dimethyl-5-carboxyethylene-2-furanpentanoic acid 0
                  3,4-dimethyl-5-carboxymethyl-2-furanpropanoic acid 0
                  3,4-dimethyl-5-carboxypropyl-2-furanpentanoic acid 0
                  3,4-dimethyl-5-propyl-2-furanoctanoic acid; 0
                  3-(3-methylfuran-2,5-diyl)-dipropionic acid 0
                  3-Carboxy-4-methyl-5-pentyl-2-furanpropanoic acid 0
                  3-Methyl-5-pentyl-2-furanpentanoic acid 0
                  3-Methyl-5-propyl-2-furanheptanoic acid 0
                  3-Methyl-5-propyl-2-furannonanoic acid 0
                  3-carboxy-4-methyl-5-(1-hydroxypropyl)-2-furanpropionic acid 0
                  3-carboxy-4-methyl-5-(4-hydroxypentyl)-2-furanpropanoic acid 0
                  3-carboxy-4-methyl-5-(4-oxopentyl)-2-furanpropanoic acid 0
                  3-carboxy-4-methyl-5-propylene-2-furanpropanoic acid 0
                  3-methyl-5-carboxypropyl-2-furanpropanoic acid 0
                  4'-oxomacrophorin D 0
                  4-(4-ethyl-1-piperazinyl)-4-oxo-2-butenoic acid 0
                  4-methyl-5-carboxyethyl-2-furanacrylic acid 0
                  4-methyl-5-carboxyethyl-2-furanpentanoic acid 0
                  5-((E)-hept-4-en-2-yne-1-one-1-yl)-2-furanacrylic acid 0
                  5-Butyl-2-furanoctanoic acid 0
                  5-Hexyl-2-furanhexanoic acid 0
                  5-Pentyl-2-furanheptanoic acid 0
                  5-Pentyl-2-furanoctanoic acid 0
                  7-(3-methyl-5-pentylfuran-2-yl)-heptanoic acid 0
                  8-(5-hexylfuran-2-yl)octanoic acid 0
                  9-(3,4-dimethyl-5-butylfuran-2-yl)-nonanoic acid 0
                  9-(3,4-dimethyl-5-pentylfuran-2-yl)-nonanoic acid 0
                  9-(3-Methyl-5-pentyl-2-furyl)nonanoic acid 0
                  Ambuic acid 0
                  Armillariol C 0
                  Arvoredol 0
                  Aspergifuranone 0
                  Bisnorbiotin 0
                  Communiol A 0
                  Communiol B 0
                  DG(11D3/13D5/0:0) 0
                  DG(11D5/11M5/0:0) 0
                  DG(13D5/11M5/0:0) 0
                  DG(13M5/13D5/0:0) 0
                  DG(9D3/9D3/0:0) 0
                  Demethyl-harzianic acid 0
                  Dihydrowyerol 0
                  Dihydrowyerone 0
                  Dihydrowyerone acid 0
                  Dioscoretine 0
                  Ficifuranone A 0
                  Flavodonfuran 0
                  GW 0791 0
                  Harzianic acid 0
                  Homoharzianic acid 0
                  Irpexlacte D 0
                  Isoharzianic acid 0
                  Kijimicin 0
                  Laidlomycin 0
                  Mumiamicin 0
                  Myxofacycline A 0
                  Myxofacycline B 0
                  Myxofacycline D 0
                  Myxofacycline G 0
                  Neoenterocin A 0
                  Neoenterocin B 0
                  Neotetrafibricin A 0
                  Oxazoltetraene acid 0
                  Oxazoltriene acid 0
                  Pestalic acid B 0
                  Pestalic acid E 0
                  Phellilin C 0
                  Pteridic acid C 0
                  Pteridic acid D 0
                  Tricycloalternarene A 0
                  Tricycloalternarene L 0
                  Trihazone F 0
                  Varicidin A 0
                  Varicidin B 0
                  Wyerol 0
                  Wyerone 0
                  Wyerone acid 0
                  Wyerone epoxide 0
                  Wyeronic acid 0
                  Zopfiellamide A 0
                  Zopfiellamide B 0
                  epoxy fatty acid + 18
                  lipoic acid + 217
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic group 23608
                              organic divalent group 23569
                                organodiyl group 23569
                                  carbonyl group 23563
                                    carbonyl compound 23563
                                      carboxylic acid 22717
                                        monocarboxylic acid 21715
                                          fatty acid 18995
                                            cyclic fatty acid 550
                                              heterocyclic fatty acid 226
                                                (2E,11Z)-5-[5-(Methylthio)-4-penten-2-ynyl]-2-furanacrolein 0
                                                (2E,11Z)-Wyerone acid 0
                                                (2S)-1-hydroxy-3-\{[9-(3-methyl-5-pentylfuran-2-yl)nonanoyl]oxy\}propan-2-yl 13-(3,4-dimethyl-5-pentylfuran-2-yl)tridecanoate 0
                                                (2S)-2-\{[11-(3,4-dimethyl-5-pentylfuran-2-yl)undecanoyl]oxy\}-3-hydroxypropyl 13-(3-methyl-5-pentylfuran-2-yl)tridecanoate 0
                                                (2S,3R,4S)-4-[(2S,7S,8R,9S)-2-[(5S)-5-ethyl-5-[(3S,5R)-5-[(3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2-oxanyl]-3-methyl-2-oxolanyl]-2-oxolanyl]-7-hydroxy-2,8-dimethyl-1,10-dioxaspiro[4.5]decan-9-yl]-3-methoxy-2-methylpentanoic acid 0
                                                (5R,7S,8S)-Communiol A 0
                                                (5R,7S,8S)-Communiol B 0
                                                (E)-4-[(1R,5R,6R)-3-[(1E,3E)-hepta-1,3-dienyl]-5-hydroxy-4-(hydroxymethyl)-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methylbut-2-enoic acid 0
                                                (E)-4-[(1R,5R,6R)-3-heptyl-5-hydroxy-4-(hydroxymethyl)-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methylbut-2-enoic acid 0
                                                (E)-4-[(1R,5R,6R)-4-(acetyloxymethyl)-3-[(E)-hept-1-enyl]-5-hydroxy-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methylbut-2-enoic acid 0
                                                (E)-4-[(1R,5R,6R)-5-hydroxy-4-(hydroxymethyl)-2-oxo-3-[(E)-5-oxohept-1-enyl]-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methylbut-2-enoic acid 0
                                                (E)-4-[(1S,2S,6S)-3-[(E)-hept-1-enyl]-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methylbut-2-enoic acid 0
                                                (E)-4-[(1S,2S,6S)-4-[chloro(methoxy)methyl]-2-hydroxy-3-(2-hydroxyheptyl)-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methylbut-2-enoic acid 0
                                                (E)-4-[(1aR,7aR,7bR)-3-[(E)-hept-1-enyl]-6,6-dimethyl-2-oxo-7a,7b-dihydro-4H-oxireno[2,3-h][1,3]benzodioxin-1a-yl]-2-methylbut-2-enoic acid 0
                                                (R)-lipoic acid + 216
                                                (S)-lipoic acid + 0
                                                1-(5-(1,2-dihydroxypropyl)-furan-2-yl)-pentan-1-one 0
                                                1-(5-(1-hydroxypentyl)furan-2-yl)propane-1,2-diol 0
                                                1-(5-(1-methoxypent-4-en-1-yl)furan-2-yl)propane-1,2-diol 0
                                                1-(5-(1-methoxypentyl)furan-2-yl)propane-1,2-diol 0
                                                1-(5-(2-hydroxybutyl)furan-2-yl)-3-methoxybutan-2-OL 0
                                                1-(5-(2-hydroxypropanoyl)-furan-2-yl)-pentan-3-one 0
                                                10-(3,4-dimethyl-5-pentylfuran-2-yl)-decanoic acid 0
                                                2-(5-((2Z,5Z,8Z,11Z)-tetradeca-2,5,8,11-tetraen-1-yl)furan-2-yl)-ethanoic acid 0
                                                2-(5-((3Z,13Z)-eicosa-3,13-dien-1-yl)furan-2-yl)-ethanoic acid 0
                                                2-(5-hexadecylfuran-2-yl)-acetic acid 0
                                                2-Butyl-5-[2-(4-hydroxy-3-methoxyphenyl)ethyl]furan 0
                                                2-Demethylmonensin A 0
                                                2-Demethylmonensin B 0
                                                2-Hexyl-5-[2-(4-hydroxy-3-methoxyphenyl)ethyl]furan 0
                                                2-Hydroxy-3-(10-methyl-2,7-dioxooxecan-5-yl)sulfanylpropanoic acid 0
                                                2-carboxyethyl-5-furanpentanoic acid 0
                                                2-cyano-N-(2,4-dichlorophenyl)-3-[5-(2-methylcyclopropyl)-2-furanyl]-2-propenamide 0
                                                2-hydroxy-1-(5-(1-hydroxypentyl)-furan-2-yl)-propan-1-one 0
                                                26-deoxymonensin A 0
                                                3,4-Dimethyl-5-pentyl-2-furanheptanoic acid 0
                                                3,4-Dimethyl-5-pentyl-2-furanpentanoic acid 0
                                                3,4-Dimethyl-5-pentyl-2-furanpropanoic acid 0
                                                3,4-dimethyl-5-carboxybutyl-2-furanpentanoic acid 0
                                                3,4-dimethyl-5-carboxyethyl-2-furanacrylic acid 0
                                                3,4-dimethyl-5-carboxyethyl-2-furanbutanoic acid 0
                                                3,4-dimethyl-5-carboxyethyl-2-furanhexanoic acid 0
                                                3,4-dimethyl-5-carboxyethyl-2-furanpentanoic acid 0
                                                3,4-dimethyl-5-carboxyethyl-2-furanpropanoic acid 0
                                                3,4-dimethyl-5-carboxyethylene-2-furanpentanoic acid 0
                                                3,4-dimethyl-5-carboxymethyl-2-furanpropanoic acid 0
                                                3,4-dimethyl-5-carboxypropyl-2-furanpentanoic acid 0
                                                3,4-dimethyl-5-propyl-2-furanoctanoic acid; 0
                                                3-(3-methylfuran-2,5-diyl)-dipropionic acid 0
                                                3-Carboxy-4-methyl-5-pentyl-2-furanpropanoic acid 0
                                                3-Methyl-5-pentyl-2-furanpentanoic acid 0
                                                3-Methyl-5-propyl-2-furanheptanoic acid 0
                                                3-Methyl-5-propyl-2-furannonanoic acid 0
                                                3-carboxy-4-methyl-5-(1-hydroxypropyl)-2-furanpropionic acid 0
                                                3-carboxy-4-methyl-5-(4-hydroxypentyl)-2-furanpropanoic acid 0
                                                3-carboxy-4-methyl-5-(4-oxopentyl)-2-furanpropanoic acid 0
                                                3-carboxy-4-methyl-5-propylene-2-furanpropanoic acid 0
                                                3-methyl-5-carboxypropyl-2-furanpropanoic acid 0
                                                4'-oxomacrophorin D 0
                                                4-(4-ethyl-1-piperazinyl)-4-oxo-2-butenoic acid 0
                                                4-methyl-5-carboxyethyl-2-furanacrylic acid 0
                                                4-methyl-5-carboxyethyl-2-furanpentanoic acid 0
                                                5-((E)-hept-4-en-2-yne-1-one-1-yl)-2-furanacrylic acid 0
                                                5-Butyl-2-furanoctanoic acid 0
                                                5-Hexyl-2-furanhexanoic acid 0
                                                5-Pentyl-2-furanheptanoic acid 0
                                                5-Pentyl-2-furanoctanoic acid 0
                                                7-(3-methyl-5-pentylfuran-2-yl)-heptanoic acid 0
                                                8-(5-hexylfuran-2-yl)octanoic acid 0
                                                9-(3,4-dimethyl-5-butylfuran-2-yl)-nonanoic acid 0
                                                9-(3,4-dimethyl-5-pentylfuran-2-yl)-nonanoic acid 0
                                                9-(3-Methyl-5-pentyl-2-furyl)nonanoic acid 0
                                                Ambuic acid 0
                                                Armillariol C 0
                                                Arvoredol 0
                                                Aspergifuranone 0
                                                Bisnorbiotin 0
                                                Communiol A 0
                                                Communiol B 0
                                                DG(11D3/13D5/0:0) 0
                                                DG(11D5/11M5/0:0) 0
                                                DG(13D5/11M5/0:0) 0
                                                DG(13M5/13D5/0:0) 0
                                                DG(9D3/9D3/0:0) 0
                                                Demethyl-harzianic acid 0
                                                Dihydrowyerol 0
                                                Dihydrowyerone 0
                                                Dihydrowyerone acid 0
                                                Dioscoretine 0
                                                Ficifuranone A 0
                                                Flavodonfuran 0
                                                GW 0791 0
                                                Harzianic acid 0
                                                Homoharzianic acid 0
                                                Irpexlacte D 0
                                                Isoharzianic acid 0
                                                Kijimicin 0
                                                Laidlomycin 0
                                                Mumiamicin 0
                                                Myxofacycline A 0
                                                Myxofacycline B 0
                                                Myxofacycline D 0
                                                Myxofacycline G 0
                                                Neoenterocin A 0
                                                Neoenterocin B 0
                                                Neotetrafibricin A 0
                                                Oxazoltetraene acid 0
                                                Oxazoltriene acid 0
                                                Pestalic acid B 0
                                                Pestalic acid E 0
                                                Phellilin C 0
                                                Pteridic acid C 0
                                                Pteridic acid D 0
                                                Tricycloalternarene A 0
                                                Tricycloalternarene L 0
                                                Trihazone F 0
                                                Varicidin A 0
                                                Varicidin B 0
                                                Wyerol 0
                                                Wyerone 0
                                                Wyerone acid 0
                                                Wyerone epoxide 0
                                                Wyeronic acid 0
                                                Zopfiellamide A 0
                                                Zopfiellamide B 0
                                                epoxy fatty acid + 18
                                                lipoic acid + 217
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