Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

go back to main search page
Accession:CHEBI:48845 term browser browse the term
Definition:A pyrroloindole that is 1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole substituted by methyl groups at positions 1, 3a and 8 and a hydroxy group at position 5. It is a metabolite of physostigmine and causes neuronal cell death by a mechanism involving loss of cell ATP.
Synonyms:exact_synonym: (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol
 related_synonym: Formula=C13H18N2O;   InChI=1S/C13H18N2O/c1-13-6-7-14(2)12(13)15(3)11-5-4-9(16)8-10(11)13/h4-5,8,12,16H,6-7H2,1-3H3/t12-,13+/m1/s1;   InChIKey=HKGWQUVGHPDEBZ-OLZOCXBDSA-N;   SMILES=CN1CC[C@]2(C)[C@H]1N(C)c1ccc(O)cc21
 xref: Beilstein:85274;   CAS:469-22-7;   LINCS:LSM-36457
 xref_mesh: MESH:C022594
 xref: PMID:2251681;   PMID:22931533;   PMID:6293841;   PMID:7194726;   PMID:7279315;   PMID:8961166;   Reaxys:85274;   Wikipedia:Eseroline

show annotations for term's descendants           Sort by:
eseroline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP eseroline results in decreased activity of ACHE protein CTD PMID:8961166 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        pharmacological role 19090
          analgesic 14629
            opioid analgesic 656
              eseroline 1
                5-O-[8-(cis-2,6-dimethylmorpholino)octylcarbamoyl]eseroline 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  organic heteropolycyclic compound 18298
                                    organic heterotricyclic compound 15598
                                      pyrroloindole 8
                                        eseroline 1
                                          5-O-[8-(cis-2,6-dimethylmorpholino)octylcarbamoyl]eseroline 0
paths to the root