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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:eseroline
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Accession:CHEBI:48845 term browser browse the term
Definition:A pyrroloindole that is 1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole substituted by methyl groups at positions 1, 3a and 8 and a hydroxy group at position 5. It is a metabolite of physostigmine and causes neuronal cell death by a mechanism involving loss of cell ATP.
Synonyms:exact_synonym: (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol
 related_synonym: Formula=C13H18N2O;   InChI=1S/C13H18N2O/c1-13-6-7-14(2)12(13)15(3)11-5-4-9(16)8-10(11)13/h4-5,8,12,16H,6-7H2,1-3H3/t12-,13+/m1/s1;   InChIKey=HKGWQUVGHPDEBZ-OLZOCXBDSA-N;   SMILES=CN1CC[C@]2(C)[C@H]1N(C)c1ccc(O)cc21
 xref: Beilstein:85274;   CAS:469-22-7;   LINCS:LSM-36457
 xref_mesh: MESH:C022594
 xref: PMID:2251681;   PMID:22931533;   PMID:6293841;   PMID:7194726;   PMID:7279315;   PMID:8961166;   Reaxys:85274;   Wikipedia:Eseroline


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eseroline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP eseroline results in decreased activity of ACHE protein CTD PMID:8961166 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        pharmacological role 19122
          analgesic 14785
            opioid analgesic 669
              eseroline 1
                5-O-[8-(cis-2,6-dimethylmorpholino)octylcarbamoyl]eseroline 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            organic molecule 19754
                              organic cyclic compound 19544
                                organic heterocyclic compound 18909
                                  organic heteropolycyclic compound 18316
                                    organic heterotricyclic compound 15655
                                      pyrroloindole 8
                                        eseroline 1
                                          5-O-[8-(cis-2,6-dimethylmorpholino)octylcarbamoyl]eseroline 0
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