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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:naphthalenecarboxamide
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Accession:CHEBI:48739 term browser browse the term
Definition:Any member of the class of naphthalenes in which the naphthalene ring is directly attached to the carbonyl carbon of a carboxamide group.
Synonyms:related_synonym: naphthalenecarboxamides


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nafadotride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 multiple interactions ISO nafadotride binds to and results in decreased activity of DRD2 protein CTD PMID:10728880 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO nafadotride binds to and results in decreased activity of DRD3 protein; nafadotride inhibits the reaction [7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in increased activity of DRD3 protein] CTD PMID:10683862, PMID:10728880 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP nafadotride results in increased expression of FOS mRNA CTD PMID:9751140, PMID:10432116 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          nitrogen atom 18565
            nitrogen molecular entity 18565
              amide 17412
                aromatic amide 6686
                  arenecarboxamide 6512
                    naphthalenecarboxamide 3
                      1-methoxy-N-[4-(pyridin-4-ylmethyl)phenyl]-2-naphthalenecarboxamide 0
                      2-naphthalenyl-(4-phenyl-1-piperazinyl)methanone 0
                      2-naphthol AS BI-beta-D-glucuronide 0
                      3-[2-(2-furanylmethylamino)-2-oxoethoxy]-N-(2-methoxy-5-methylphenyl)-2-naphthalenecarboxamide 0
                      3-[2-(tert-butylamino)-2-oxoethoxy]-N-(4-chloro-2,5-dimethoxyphenyl)-2-naphthalenecarboxamide 0
                      3-hydroxy-N-[[2-oxo-1-(phenylmethyl)-3-indolylidene]amino]-2-naphthalenecarboxamide 0
                      3-methoxy-N-(5-methyl-2-pyridinyl)-2-naphthalenecarboxamide 0
                      3-methoxy-N-[2-(4-methoxyphenyl)-2-(1-pyrrolidinyl)ethyl]-2-naphthalenecarboxamide 0
                      5-(1,3-benzodioxol-5-ylmethyl)-4-methyl-2-[[1-naphthalenyl(oxo)methyl]amino]-3-thiophenecarboxamide 0
                      6-(7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthalenecarboxamide 0
                      6-[oxo-[4-(phenylmethyl)-1-piperazinyl]methyl]-2-[3-(trifluoromethyl)phenyl]benzo[de]isoquinoline-1,3-dione 0
                      E-3810 free base 0
                      N-(2,2,2-trichloro-1-diethoxyphosphorylethyl)-1-naphthalenecarboxamide 0
                      N-(2-methyl-1,3-dioxo-5-isoindolyl)-1-naphthalenecarboxamide 0
                      N-(2-methyl-5-tetrazolyl)-2-naphthalenecarboxamide 0
                      N-(3-acetylphenyl)-2-naphthalenecarboxamide 0
                      N-(3-bicyclo[2.2.1]heptanylideneamino)-3-hydroxy-2-naphthalenecarboxamide 0
                      N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-naphthalenecarboxamide 0
                      N-(4-ethoxyphenyl)-3-hydroxy-2-naphthalenecarboxamide 0
                      N-(4-hydroxyphenyl)-3-methoxy-2-naphthalenecarboxamide 0
                      N-(6-chloro-1,3-benzothiazol-2-yl)-N-[3-(dimethylamino)propyl]-5,6,7,8-tetrahydronaphthalene-2-carboxamide 0
                      N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]-2-naphthalenecarboxamide 0
                      N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-2-naphthalenecarboxamide 0
                      N-[3-cyano-6-(3-piperidin-1-ylpropanoyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]naphthalene-1-carboxamide 0
                      N-[4-(1-pyrrolidinyl)phenyl]-2-naphthalenecarboxamide 0
                      N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-2-naphthalenecarboxamide 0
                      N-[5-[[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]thio]-1,3,4-thiadiazol-2-yl]-1-naphthalenecarboxamide 0
                      N-[[5-(1,3-benzothiazol-2-yl)-2-methylanilino]-sulfanylidenemethyl]-1-naphthalenecarboxamide 0
                      N-tert-butyl-1,2-dihydroacenaphthylene-5-carboxamide 0
                      [4-[(2-fluorophenyl)methyl]-1-piperazinyl]-(1-naphthalenyl)methanone 0
                      bunaftine 0
                      nafadotride 3
                      naphthalene-2-carboxamide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                monocarboxylic acid amide 14573
                                                  arenecarboxamide 6512
                                                    naphthalenecarboxamide 3
                                                      1-methoxy-N-[4-(pyridin-4-ylmethyl)phenyl]-2-naphthalenecarboxamide 0
                                                      2-naphthalenyl-(4-phenyl-1-piperazinyl)methanone 0
                                                      2-naphthol AS BI-beta-D-glucuronide 0
                                                      3-[2-(2-furanylmethylamino)-2-oxoethoxy]-N-(2-methoxy-5-methylphenyl)-2-naphthalenecarboxamide 0
                                                      3-[2-(tert-butylamino)-2-oxoethoxy]-N-(4-chloro-2,5-dimethoxyphenyl)-2-naphthalenecarboxamide 0
                                                      3-hydroxy-N-[[2-oxo-1-(phenylmethyl)-3-indolylidene]amino]-2-naphthalenecarboxamide 0
                                                      3-methoxy-N-(5-methyl-2-pyridinyl)-2-naphthalenecarboxamide 0
                                                      3-methoxy-N-[2-(4-methoxyphenyl)-2-(1-pyrrolidinyl)ethyl]-2-naphthalenecarboxamide 0
                                                      5-(1,3-benzodioxol-5-ylmethyl)-4-methyl-2-[[1-naphthalenyl(oxo)methyl]amino]-3-thiophenecarboxamide 0
                                                      6-(7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthalenecarboxamide 0
                                                      6-[oxo-[4-(phenylmethyl)-1-piperazinyl]methyl]-2-[3-(trifluoromethyl)phenyl]benzo[de]isoquinoline-1,3-dione 0
                                                      E-3810 free base 0
                                                      N-(2,2,2-trichloro-1-diethoxyphosphorylethyl)-1-naphthalenecarboxamide 0
                                                      N-(2-methyl-1,3-dioxo-5-isoindolyl)-1-naphthalenecarboxamide 0
                                                      N-(2-methyl-5-tetrazolyl)-2-naphthalenecarboxamide 0
                                                      N-(3-acetylphenyl)-2-naphthalenecarboxamide 0
                                                      N-(3-bicyclo[2.2.1]heptanylideneamino)-3-hydroxy-2-naphthalenecarboxamide 0
                                                      N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-naphthalenecarboxamide 0
                                                      N-(4-ethoxyphenyl)-3-hydroxy-2-naphthalenecarboxamide 0
                                                      N-(4-hydroxyphenyl)-3-methoxy-2-naphthalenecarboxamide 0
                                                      N-(6-chloro-1,3-benzothiazol-2-yl)-N-[3-(dimethylamino)propyl]-5,6,7,8-tetrahydronaphthalene-2-carboxamide 0
                                                      N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]-2-naphthalenecarboxamide 0
                                                      N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-2-naphthalenecarboxamide 0
                                                      N-[3-cyano-6-(3-piperidin-1-ylpropanoyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl]naphthalene-1-carboxamide 0
                                                      N-[4-(1-pyrrolidinyl)phenyl]-2-naphthalenecarboxamide 0
                                                      N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-2-naphthalenecarboxamide 0
                                                      N-[5-[[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]thio]-1,3,4-thiadiazol-2-yl]-1-naphthalenecarboxamide 0
                                                      N-[[5-(1,3-benzothiazol-2-yl)-2-methylanilino]-sulfanylidenemethyl]-1-naphthalenecarboxamide 0
                                                      N-tert-butyl-1,2-dihydroacenaphthylene-5-carboxamide 0
                                                      [4-[(2-fluorophenyl)methyl]-1-piperazinyl]-(1-naphthalenyl)methanone 0
                                                      bunaftine 0
                                                      nafadotride 3
                                                      naphthalene-2-carboxamide 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.