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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-nitroanisole
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Accession:CHEBI:48722 term browser browse the term
Definition:A member of the class of 2-nitroanisoles that is anisole in which one of the hydrogens ortho to the methoxy group is replaced by a nitro group.
Synonyms:exact_synonym: 1-methoxy-2-nitrobenzene
 related_synonym: 1-Nitro-2-methoxybenzene;   Formula=C7H7NO3;   InChI=1S/C7H7NO3/c1-11-7-5-3-2-4-6(7)8(9)10/h2-5H,1H3;   InChIKey=CFBYEGUGFPZCNF-UHFFFAOYSA-N;   SMILES=COc1ccccc1[N+]([O-])=O;   o-Nitroanisole;   o-Nitrophenyl methyl ether;   o-methoxynitrobenzene
 xref: Beilstein:1868032;   CAS:91-23-6;   KEGG:C19270
 xref_mesh: MESH:C005328
 xref: PMID:16601807;   PMID:21187827;   PMID:21217841;   PMID:21946300;   Patent:CN101643419;   Reaxys:1868032


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2-nitroanisole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases oxidation
increases expression
ISO
EXP
CYP1A1 protein results in increased metabolism of 2-nitroanisole
CYP1A1 protein results in increased oxidation of 2-nitroanisole
2-nitroanisole results in increased expression of CYP1A1
CTD PMID:11409192, PMID:15144223, PMID:17159769, PMID:21218109 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP 2-nitroanisole results in increased expression of CYP1A2; 2-nitroanisole results in increased expression of CYP1A2 protein CTD PMID:11409192, PMID:16601807 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases oxidation EXP CYP2B2 protein results in increased oxidation of 2-nitroanisole CTD PMID:21218109 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases oxidation
increases metabolic processing
ISO CYP2B6 protein results in increased oxidation of 2-nitroanisole
CYP2B6 protein results in increased metabolism of 2-nitroanisole
CTD PMID:15144223, PMID:17159769, PMID:21218109 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases oxidation EXP
ISO
CYP2C6V1 protein results in increased oxidation of 2-nitroanisole
CYP2C19 protein results in increased oxidation of 2-nitroanisole
CTD PMID:21218109 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 increases oxidation EXP CYP2D2 protein results in increased oxidation of 2-nitroanisole CTD PMID:21218109 NCBI chr 7:123,651,827...123,655,896
Ensembl chr 7:123,651,827...123,655,896
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
increases oxidation
ISO
EXP
CYP2E1 protein results in increased metabolism of 2-nitroanisole
CYP2E1 protein results in increased oxidation of 2-nitroanisole
CTD PMID:15144223, PMID:17159769, PMID:21218109 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G H2ax H2A.X variant histone increases expression EXP 2-nitroanisole results in increased expression of H2AX protein CTD PMID:26338220 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP 2-nitroanisole results in increased expression of NQO1 CTD PMID:11409192 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Xdh xanthine dehydrogenase increases reduction ISO XDH protein results in increased reduction of 2-nitroanisole CTD PMID:14729594 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

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  CHEBI ontology 19816
    role 19764
      biological role 19764
        aetiopathogenetic role 18960
          carcinogenic agent 18331
            2-nitroanisole 10
Path 2
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  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                carbocyclic compound 18222
                                  benzenoid aromatic compound 17254
                                    benzenes 17010
                                      methoxybenzenes 1835
                                        monomethoxybenzene 1741
                                          anisole 10
                                            nitroanisoles 10
                                              mononitroanisoles 10
                                                2-nitroanisoles 10
                                                  2-nitroanisole 10
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