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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:argatroban
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Accession:CHEBI:48720 term browser browse the term
Definition:An alpha-N-substituted L-arginine that has formula C23H36N6O5S.
Synonyms:alt_id: CHEBI:184;   CHEBI:44028
 xref_mesh: MESH:C031942


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argatroban term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of ACTA2 protein] CTD PMID:22841818 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of ADGRE1 mRNA] CTD PMID:22841818 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of CCL2 mRNA]; argatroban inhibits the reaction [Dietary Fats results in increased expression of CCL2 protein] CTD PMID:22841818 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of CD68 mRNA] CTD PMID:22841818 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of COL1A1 mRNA] CTD PMID:22841818 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO argatroban affects the reaction [Dietary Fats results in increased expression of CXCL2 mRNA] CTD PMID:22841818 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G F2 coagulation factor II multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of F2 protein]
argatroban binds to and results in decreased activity of F2 protein		 CTD PMID:15080313 PMID:16084352 PMID:18449412 PMID:22841818 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of ICAM1 mRNA] CTD PMID:22841818 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO argatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]; argatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Triglycerides] CTD PMID:22841818 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO argatroban inhibits the reaction [Dietary Fats results in increased expression of TIMP1 mRNA] CTD PMID:22841818 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        refrigerant 18162
          ammonia 17654
            organic amino compound 17654
              secondary amino compound 6768
                argatroban 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        amino acid 15541
                                          alpha-amino acid 13675
                                            L-alpha-amino acid 12607
                                              glutamine family amino acid 10311
                                                L-arginine 74
                                                  L-arginine derivative 59
                                                    alpha-N-substituted L-arginine 10
                                                      argatroban 10
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