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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(-)-citrinin
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Accession:CHEBI:48707 term browser browse the term
Definition:A citrinin that has formula C13H14O5.
Synonyms:exact_synonym: (3R,4S)-8-hydroxy-3,4,5-trimethyl-6-oxo-4,6-dihydro-3H-isochromene-7-carboxylic acid
 related_synonym: (3R,4S)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid;   (3R-trans)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid;   Formula=C13H14O5;   InChI=1S/C13H14O5/c1-5-7(3)18-4-8-9(5)6(2)11(14)10(12(8)15)13(16)17/h4-5,7,15H,1-3H3,(H,16,17)/t5-,7-/m1/s1;   InChIKey=CQIUKKVOEOPUDV-IYSWYEEDSA-N;   SMILES=C[C@H]1OC=C2C(O)=C(C(O)=O)C(=O)C(C)=C2[C@@H]1C
 xref: Beilstein:5282243;   Beilstein:88597;   CAS:518-75-2;   KEGG:C16765;   KNApSAcK:C00029979
 xref_mesh: MESH:D002953
 cyclic_relationship: is_enantiomer_of CHEBI:48712


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(-)-citrinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO [ochratoxin A co-treated with Citrinin] results in increased expression of ACTA2 mRNA; [ochratoxin A co-treated with Citrinin] results in increased expression of ACTA2 protein CTD PMID:29673704 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Citrinin results in increased expression of ATF3 mRNA CTD PMID:21844328 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Citrinin results in increased expression of ATF4 mRNA CTD PMID:21844328 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atg5 autophagy related 5 increases expression ISO Citrinin results in increased expression of ATG5 mRNA CTD PMID:22771370 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Bag3 BAG cochaperone 3 increases expression
multiple interactions
ISO Citrinin results in increased expression of BAG3 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of BAG3 mRNA; [Citrinin co-treated with ochratoxin A] results in increased expression of BAG3 mRNA
CTD PMID:30428381 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
multiple interactions
ISO Citrinin results in increased expression of BAK1 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of BAK1 mRNA
CTD PMID:30428381 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
affects expression
ISO Citrinin results in increased expression of BAX protein
Citrinin affects the expression of BAX protein
CTD PMID:21622943 PMID:22771370 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
affects expression
ISO Citrinin results in decreased expression of BCL2 protein
Citrinin affects the expression of BCL2 protein
CTD PMID:21622943 PMID:22771370 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l12 BCL2 like 12 increases expression
multiple interactions
ISO Citrinin results in increased expression of BCL2L12 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of BCL2L12 mRNA
CTD PMID:30428381 NCBI chr 1:100,984,550...100,993,269
Ensembl chr 1:100,984,550...100,993,269
JBrowse link
G Becn1 beclin 1 increases expression ISO Citrinin results in increased expression of BECN1 mRNA CTD PMID:22771370 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp2 caspase 2 decreases expression
multiple interactions
ISO Citrinin results in decreased expression of CASP2 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CASP2 mRNA
CTD PMID:30428381 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression
ISO
EXP
Citrinin results in increased activity of CASP3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Citrinin results in increased activity of CASP3 protein]; Citrinin inhibits the reaction [ochratoxin A results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Citrinin results in increased activity of CASP3 protein]
[Citrinin results in increased activity of CASP3 protein] which results in increased activity of PAK2 protein; Citrinin results in increased activity of CASP3 protein
Citrinin results in increased expression of CASP3 protein modified form
CTD PMID:18767140 PMID:19361540 PMID:21622943 PMID:22564900 PMID:29673704 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity
increases expression
ISO
EXP
Citrinin results in increased activity of CASP9 protein
Citrinin results in increased expression of CASP9 protein modified form
CTD PMID:21622943 PMID:22564900 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases activity ISO Citrinin results in increased activity of CAT protein CTD PMID:21622943 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccna2 cyclin A2 increases expression EXP Citrinin results in increased expression of CCNA2 mRNA CTD PMID:23856526 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 increases expression
decreases expression
multiple interactions
EXP
ISO
Citrinin results in increased expression of CCNB1 mRNA
Citrinin results in decreased expression of CCNB1 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CCNB1 mRNA
CTD PMID:23856526 PMID:30428381 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions
decreases expression
EXP
ISO
Citrinin results in increased expression of CCNE1 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CCNE1 mRNA
Citrinin results in decreased expression of CCNE1 mRNA
CTD PMID:23856526 PMID:30428381 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CCNG1 mRNA; [Citrinin co-treated with ochratoxin A] results in decreased expression of CCNG1 protein CTD PMID:30428381 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Cdc23 cell division cycle 23 decreases expression
multiple interactions
ISO Citrinin results in decreased expression of CDC23 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CDC23 mRNA
CTD PMID:30428381 NCBI chr18:27,430,924...27,452,569
Ensembl chr18:27,430,905...27,452,420
JBrowse link
G Cdc25a cell division cycle 25A multiple interactions
decreases expression
increases expression
ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CDC25A mRNA
Citrinin results in decreased expression of CDC25A mRNA
Citrinin results in increased expression of CDC25A mRNA
CTD PMID:30428381 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions
decreases expression
ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CDC25C mRNA
Citrinin results in decreased expression of CDC25C mRNA
CTD PMID:30428381 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdc26 cell division cycle 26 multiple interactions
decreases expression
ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CDC26 mRNA
Citrinin results in decreased expression of CDC26 mRNA
CTD PMID:30428381 NCBI chr 5:78,252,168...78,267,137
Ensembl chr 5:78,253,397...78,267,063
JBrowse link
G Cdc34 cell division cycle 34, ubiqiutin conjugating enzyme multiple interactions
decreases expression
ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CDC34 mRNA
Citrinin results in decreased expression of CDC34 mRNA
CTD PMID:30428381 NCBI chr 7:12,899,957...12,905,339
Ensembl chr 7:12,899,958...12,905,339
JBrowse link
G Cdc6 cell division cycle 6 multiple interactions
decreases expression
ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CDC6 mRNA
Citrinin results in decreased expression of CDC6 mRNA
CTD PMID:30428381 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdc7 cell division cycle 7 decreases expression
multiple interactions
ISO Citrinin results in decreased expression of CDC7 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CDC7 mRNA
CTD PMID:30428381 NCBI chr14:3,826,658...3,846,891
Ensembl chr14:3,826,659...3,846,891
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CDH1 mRNA; [ochratoxin A co-treated with Citrinin] results in decreased expression of CDH1 protein CTD PMID:29673704 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions
ISO Citrinin results in decreased expression of CDK1 protein modified form
[Citrinin co-treated with ochratoxin A] results in decreased expression of CDK1 mRNA
CTD PMID:20929984 PMID:30428381 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk10 cyclin-dependent kinase 10 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of CDK10 mRNA CTD PMID:30428381 NCBI chr19:56,024,903...56,032,610
Ensembl chr19:56,024,903...56,032,605
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Citrinin results in increased expression of CDKN1A protein CTD PMID:20929984 PMID:21622943 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression
multiple interactions
ISO Citrinin results in decreased expression of CDKN1B mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CDKN1B mRNA; [Citrinin co-treated with ochratoxin A] results in increased expression of CDKN1B mRNA
CTD PMID:30428381 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of COL3A1 mRNA; [Citrinin co-treated with ochratoxin A] results in increased expression of and results in increased secretion of COL3A1 protein CTD PMID:29673704 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Citrinin affects the localization of CYCS protein CTD PMID:21622943 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Citrinin results in decreased expression of CYP11A1 protein CTD PMID:22564900 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Citrinin results in increased expression of DDIT3 mRNA CTD PMID:21844328 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G E2f1 E2F transcription factor 1 increases expression EXP Citrinin results in increased expression of E2F1 mRNA CTD PMID:23856526 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
ISO Citrinin results in increased expression of EGR1 mRNA; Citrinin results in increased expression of EGR1 protein
U 0126 inhibits the reaction [Citrinin results in increased expression of EGR1 protein]
CTD PMID:19361540 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Citrinin results in increased expression of FOS mRNA; Citrinin results in increased expression of FOS protein
U 0126 inhibits the reaction [Citrinin results in increased expression of FOS protein]
CTD PMID:19361540 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression
multiple interactions
ISO Citrinin results in increased expression of GADD45B mRNA
U 0126 inhibits the reaction [Citrinin results in increased expression of GADD45B mRNA]
CTD PMID:19361540 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Hgf hepatocyte growth factor increases expression EXP Citrinin results in increased expression of HGF mRNA CTD PMID:23856526 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Citrinin results in increased expression of HMOX1 CTD PMID:26260164 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP Citrinin results in decreased expression of HSD3B1 protein CTD PMID:22564900
G Ifng interferon gamma decreases expression
increases expression
decreases secretion
ISO Citrinin results in decreased expression of IFNG mRNA
Citrinin results in increased expression of IFNG protein
Citrinin results in decreased secretion of IFNG protein
CTD PMID:12112629 PMID:22771370 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Citrinin inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]; Citrinin inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; Citrinin inhibits the reaction [Poly I-C results in increased expression of IL10 mRNA]; Citrinin inhibits the reaction [Poly I-C results in increased expression of IL10 protein]; Citrinin inhibits the reaction [Zymosan results in increased expression of IL10 mRNA]; Citrinin inhibits the reaction [Zymosan results in increased expression of IL10 protein] CTD PMID:22771370 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO Citrinin inhibits the reaction [Poly I-C results in increased expression of IL1B mRNA]; Citrinin inhibits the reaction [Zymosan results in increased expression of IL1B mRNA]
Citrinin results in decreased expression of IL1B mRNA
CTD PMID:22771370 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Citrinin results in increased expression of JUN mRNA; Citrinin results in increased expression of JUN protein CTD PMID:19361540 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Citrinin results in increased expression of JUNB mRNA CTD PMID:19361540 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Citrinin results in increased expression of LCN2 mRNA CTD PMID:23856526 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
Citrinin results in increased phosphorylation of MAPK1 protein
Citrinin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK1 protein]; ochratoxin A promotes the reaction [Citrinin results in increased phosphorylation of MAPK1 protein]
CTD PMID:19361540 PMID:23856526 PMID:29673704 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO
EXP
Citrinin results in increased phosphorylation of MAPK3 protein
Citrinin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK3 protein]; ochratoxin A promotes the reaction [Citrinin results in increased phosphorylation of MAPK3 protein]
CTD PMID:19361540 PMID:23856526 PMID:29673704 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Citrinin results in increased phosphorylation of MAPK8 protein CTD PMID:19361540 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Citrinin results in increased phosphorylation of MAPK9 protein CTD PMID:19361540 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mir1 microRNA 1 decreases expression
multiple interactions
ISO Citrinin results in decreased expression of MIR1 mRNA
[Citrinin co-treated with ochratoxin A] results in increased expression of MIR1 mRNA
CTD PMID:30428381 NCBI chr18:2,054,933...2,055,019 JBrowse link
G Mir107 microRNA 107 decreases expression ISO Citrinin results in decreased expression of MIR107 mRNA CTD PMID:30428381 NCBI chr 1:253,128,250...253,128,336
Ensembl chr 1:253,128,250...253,128,336
JBrowse link
G Mir122 microRNA 122 multiple interactions
increases expression
ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR122 mRNA
Citrinin results in increased expression of MIR122 mRNA
CTD PMID:30428381 NCBI chr18:60,755,285...60,755,369 JBrowse link
G Mir132 microRNA 132 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR132 mRNA CTD PMID:30428381 NCBI chr10:62,014,995...62,015,095
Ensembl chr10:62,014,995...62,015,095
JBrowse link
G Mir139 microRNA 139 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR139 mRNA CTD PMID:30428381 NCBI chr 1:166,589,545...166,589,612
Ensembl chr 1:166,589,545...166,589,612
JBrowse link
G Mir142 microRNA 142 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR142 mRNA CTD PMID:30428381 NCBI chr10:75,050,839...75,050,925
Ensembl chr10:75,050,832...75,050,942
JBrowse link
G Mir144 microRNA 144 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR144 mRNA CTD PMID:30428381 NCBI chr10:65,291,365...65,291,447
Ensembl chr10:65,291,365...65,291,447
JBrowse link
G Mir152 microRNA 152 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR152 mRNA CTD PMID:30428381 NCBI chr10:84,719,319...84,719,403
Ensembl chr10:84,719,319...84,719,403
JBrowse link
G Mir184 microRNA 184 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR184 mRNA CTD PMID:30428381 NCBI chr 8:97,175,657...97,175,733
Ensembl chr 8:97,175,657...97,175,733
JBrowse link
G Mir187 microRNA 187 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR187 mRNA CTD PMID:30428381 NCBI chr18:16,390,507...16,390,610
Ensembl chr18:16,390,507...16,390,610
JBrowse link
G Mir190b microRNA 190b multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR190B mRNA CTD PMID:30428381 NCBI chr 2:189,421,137...189,421,214
Ensembl chr 2:189,421,137...189,421,214
JBrowse link
G Mir200b microRNA 200b multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR200B mRNA CTD PMID:30428381 NCBI chr 5:173,490,144...173,490,238
Ensembl chr 5:173,490,144...173,490,238
JBrowse link
G Mir200c microRNA 200c multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR200C mRNA CTD PMID:30428381 NCBI chr 4:157,236,786...157,236,854 JBrowse link
G Mir295-1 microRNA 295-1 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR372 mRNA CTD PMID:30428381 NCBI chr 1:64,536,623...64,536,703
Ensembl chr 1:64,536,623...64,536,703
JBrowse link
G Mir301a microRNA 301a decreases expression ISO Citrinin results in decreased expression of MIR301A mRNA CTD PMID:30428381 NCBI chr10:74,417,746...74,417,845
Ensembl chr10:74,417,746...74,417,845
JBrowse link
G Mir32 microRNA 32 decreases expression ISO Citrinin results in decreased expression of MIR32 mRNA CTD PMID:30428381 NCBI chr 5:73,934,255...73,934,324
Ensembl chr 5:73,934,255...73,934,324
JBrowse link
G Mir34a microRNA 34a decreases expression ISO Citrinin results in decreased expression of MIR34A mRNA CTD PMID:30428381 NCBI chr 5:167,092,491...167,092,592
Ensembl chr 5:167,092,491...167,092,592
JBrowse link
G Mir34b microRNA 34b multiple interactions
decreases expression
ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR34B mRNA
Citrinin results in decreased expression of MIR34B mRNA
CTD PMID:30428381 NCBI chr 8:55,492,542...55,492,625
Ensembl chr 8:55,492,542...55,492,625
JBrowse link
G Mir34c microRNA 34c decreases expression
multiple interactions
ISO Citrinin results in decreased expression of MIR34C mRNA
[Citrinin co-treated with ochratoxin A] results in increased expression of MIR34C mRNA
CTD PMID:30428381 NCBI chr 8:55,492,024...55,492,100
Ensembl chr 8:55,492,024...55,492,100
JBrowse link
G Mir374b microRNA 374b decreases expression ISO Citrinin results in decreased expression of MIR374B mRNA CTD PMID:30428381 NCBI chr  X:74,443,648...74,443,715
Ensembl chr  X:74,443,648...74,443,715
JBrowse link
G Mir449a microRNA 449a multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR449A mRNA CTD PMID:30428381 NCBI chr 2:44,897,601...44,897,691
Ensembl chr 2:44,897,601...44,897,691
JBrowse link
G Mir449c microRNA 449c multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in increased expression of MIR449C mRNA CTD PMID:30428381 NCBI chr 2:44,896,066...44,896,164
Ensembl chr 2:44,896,066...44,896,164
JBrowse link
G Mir92a1 microRNA 92a-1 decreases expression ISO Citrinin results in decreased expression of MIR92A1 mRNA CTD PMID:30428381 NCBI chr15:100,180,586...100,180,663
Ensembl chr15:100,180,586...100,180,663
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression
multiple interactions
ISO Citrinin results in increased expression of MMP3 mRNA
pyrazolanthrone inhibits the reaction [Citrinin results in increased expression of MMP3 mRNA]
CTD PMID:19361540 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 increases activity ISO [Citrinin results in increased activity of CASP3 protein] which results in increased activity of PAK2 protein; Citrinin results in increased activity of PAK2 protein CTD PMID:18767140 NCBI chr11:72,829,407...72,865,815
Ensembl chr11:72,829,238...72,865,902
Ensembl chr11:72,829,238...72,865,902
JBrowse link
G Pdcd4 programmed cell death 4 multiple interactions
decreases expression
ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of PDCD4 mRNA
Citrinin results in decreased expression of PDCD4 mRNA
CTD PMID:30428381 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases activity ISO Citrinin results in decreased activity of PPARG protein CTD PMID:27481073 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Citrinin results in increased expression of PPP1R15A mRNA CTD PMID:21844328 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [ochratoxin A co-treated with Citrinin] results in decreased expression of PTGS2 mRNA; [ochratoxin A co-treated with Citrinin] results in decreased expression of PTGS2 protein CTD PMID:29673704 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions EXP Citrinin inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A] CTD PMID:10336520 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc5a1 solute carrier family 5 member 1 multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of SLC5A1 mRNA CTD PMID:29673704 NCBI chr14:82,910,448...82,975,303
Ensembl chr14:82,909,981...82,975,263
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP Citrinin results in decreased expression of STAR protein CTD PMID:22564900 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in decreased activity of THRB protein CTD PMID:27481073 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO Citrinin results in increased expression of TLR2 mRNA CTD PMID:22771370 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr3 toll-like receptor 3 decreases expression ISO Citrinin results in decreased expression of TLR3 mRNA CTD PMID:22771370 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Citrinin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Citrinin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Citrinin inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Citrinin inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Citrinin promotes the reaction [CPG-oligonucleotide results in increased expression of TNF mRNA]; Citrinin promotes the reaction [CPG-oligonucleotide results in increased expression of TNF protein]
[ochratoxin A co-treated with Citrinin] results in increased expression of TNF mRNA; [ochratoxin A co-treated with Citrinin] results in increased expression of TNF protein; pyrazolanthrone inhibits the reaction [[ochratoxin A co-treated with Citrinin] results in increased expression of TNF mRNA]; U 0126 inhibits the reaction [[ochratoxin A co-treated with Citrinin] results in increased expression of TNF mRNA]
CTD PMID:22771370 PMID:29673704 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip1 TNF alpha induced protein 1 increases expression
multiple interactions
ISO Citrinin results in increased expression of TNFAIP1 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of TNFAIP1 mRNA
CTD PMID:30428381 NCBI chr10:65,791,002...65,805,693
Ensembl chr10:65,791,003...65,805,693
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression
multiple interactions
ISO Citrinin results in increased expression of TNFRSF12A mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of TNFRSF12A mRNA
CTD PMID:30428381 NCBI chr10:12,995,904...12,997,930
Ensembl chr10:12,995,904...12,997,930
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO [Citrinin co-treated with ochratoxin A] results in decreased expression of TNFRSF1A mRNA CTD PMID:30428381 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 multiple interactions
increases expression
ISO [ochratoxin A co-treated with Citrinin] results in increased expression of TNFRSF10D mRNA
Citrinin results in increased expression of TNFRSF10D mRNA
CTD PMID:30428381 NCBI chr 1:216,808,642...216,829,361
Ensembl chr 1:216,808,632...216,828,651
JBrowse link
G Tp53 tumor protein p53 increases expression ISO
EXP
Citrinin results in increased expression of TP53 protein
Citrinin results in increased expression of TP53 protein modified form
Citrinin results in increased expression of TRP53 protein
CTD PMID:20929984 PMID:21622943 PMID:22564900 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vim vimentin multiple interactions ISO [ochratoxin A co-treated with Citrinin] results in decreased expression of VIM mRNA; [ochratoxin A co-treated with Citrinin] results in increased expression of VIM protein CTD PMID:29673704 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        biochemical role 19301
          metabolite 19282
            eukaryotic metabolite 18954
              fungal metabolite 17436
                Penicillium metabolite 1910
                  (-)-citrinin 93
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    main group molecular entity 19653
                      p-block molecular entity 19653
                        carbon group molecular entity 19569
                          organic molecular entity 19559
                            organic molecule 19493
                              organic cyclic compound 19318
                                organic heterocyclic compound 18510
                                  organic heteropolycyclic compound 17973
                                    benzopyran 10275
                                      2-benzopyran 1358
                                        isochromenes 1358
                                          8-hydroxy-3,4,5-trimethyl-6-oxo-4,6-dihydro-3H-isochromene-7-carboxylic acid 93
                                            citrinin 93
                                              (-)-citrinin 93
paths to the root