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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:estragole
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Accession:CHEBI:4867 term browser browse the term
Definition:A phenylpropanoid that is chavicol in which the hydroxy group is replaced by a methoxy group.
Synonyms:related_synonym: 1-Allyl-4-methoxybenzene;   1-Methoxy-4-(2-propen-1-yl)benzene;   1-Methoxy-4-prop-2-enylbenzene;   1-methoxy-4-(2-propenyl)benzene;   1-methoxy-4-(prop-2-en-1-yl)benzene;   3-(4-methoxyphenyl)-1-propene;   3-(p-Methoxyphenyl)propene;   3-(p-methoxyphenyl)-1-propene;   4-Allylanisole;   4-Allylmethoxybenzene;   4-Methoxyallylbenzene;   Chavicol methyl ether;   Chavicyl methyl ether;   Esdragol;   Esdragole;   Esdragon;   Estragol;   FEMA 2411;   Formula=C10H12O;   InChI=1S/C10H12O/c1-3-4-9-5-7-10(11-2)8-6-9/h3,5-8H,1,4H2,2H3;   InChIKey=ZFMSMUAANRJZFM-UHFFFAOYSA-N;   Isoanethole;   Methyl-Chavicol;   Methylchavicol;   O-Methyl-Chavicol;   O-methylchavicol;   P-Allylmethoxybenzene;   P-Allylphenyl methyl ether;   P-Methoxyallylbenzene;   SMILES=COC1=CC=C(CC=C)C=C1;   p-Allyl-Anisole;   p-Allylanisole
 xref: BPDB:1391;   CAS:140-67-0;   FooDB:FDB012392;   HMDB:HMDB0034121;   KEGG:C10452;   KNApSAcK:C00002740
 xref_mesh: MESH:C007633
 xref: MetaCyc:CPD-6484;   PMID:10552889;   PMID:10995274;   PMID:11161012;   PMID:11884690;   PMID:12575134;   PMID:12617576;   PMID:15922374;   PMID:16826298;   PMID:18095647;   PMID:18266152;   PMID:18618386;   PMID:19167006;   PMID:19913108;   PMID:20552457;   PMID:21291237;   PMID:21469658;   PMID:21834250;   PMID:21922923;   PMID:21969960;   PMID:23010670;   PMID:23020916;   PMID:24421258;   PMID:32185416;   PMID:32750650;   PMID:32853702;   PMID:33681616;   PMID:33963471;   PMID:34015424;   PMID:36627786;   PMID:36797594;   Reaxys:1099454;   Wikipedia:Estragole


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estragole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO estragole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:29191726 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Casp3 caspase 3 increases expression EXP estragole results in increased expression of CASP3 protein modified form CTD PMID:29054680 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccna2 cyclin A2 increases expression EXP estragole results in increased expression of CCNA2 mRNA CTD PMID:29054680 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 increases expression
multiple interactions		 EXP
ISO		 estragole results in increased expression of CCNB1 mRNA
flumequine promotes the reaction [estragole results in increased expression of CCNB1 mRNA]		 CTD PMID:29054680 PMID:31029721 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 increases expression EXP estragole results in increased expression of CCND1 protein CTD PMID:29054680 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions		 EXP
ISO		 estragole results in increased expression of CCNE1 mRNA
[flumequine co-treated with estragole] results in increased expression of CCNE1 mRNA		 CTD PMID:29054680 PMID:31029721 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression EXP estragole results in increased expression of CHEK1 protein CTD PMID:29054680 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO estragole inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:29191726 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation
increases expression
multiple interactions
increases response to substance		 ISO CYP1A2 protein results in increased hydroxylation of estragole
estragole results in increased expression of CYP1A2 mRNA
[flumequine co-treated with estragole] results in increased expression of CYP1A2 mRNA
CYP1A2 protein results in increased susceptibility to estragole		 CTD PMID:19920071 PMID:31029721 PMID:32853702 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases hydroxylation ISO CYP2E1 protein results in increased hydroxylation of estragole CTD PMID:19920071 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation EXP estragole results in increased phosphorylation of GSK3B protein CTD PMID:29054680 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G H2ax H2A.X variant histone increases expression EXP estragole results in increased expression of H2AX protein modified form CTD PMID:29054680 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK1 protein CTD PMID:29054680 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK3 protein CTD PMID:29054680 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK8 protein CTD PMID:29054680 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK9 protein CTD PMID:29054680 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP estragole results in increased expression of PCNA protein CTD PMID:22576464 PMID:29054680 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha increases phosphorylation EXP estragole results in increased phosphorylation of PPP2CA protein CTD PMID:29054680 NCBI chr10:36,856,534...36,878,789
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Rad51 RAD51 recombinase increases expression EXP estragole results in increased expression of RAD51 protein CTD PMID:29054680 NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation EXP estragole results in increased phosphorylation of SRC protein CTD PMID:29054680 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [flumequine co-treated with estragole] results in increased expression of TNF mRNA CTD PMID:31029721 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases phosphorylation EXP estragole results in increased phosphorylation of TP53 protein CTD PMID:29054680 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [flumequine co-treated with estragole] results in decreased expression of UGT1A1 mRNA CTD PMID:31029721 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19870
      biological role 19868
        insect attractant 91
          estragole 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19725
                              organic cyclic compound 19517
                                carbocyclic compound 18622
                                  benzenoid aromatic compound 18093
                                    benzenes 17971
                                      methoxybenzenes 2891
                                        monomethoxybenzene 1868
                                          estragole 23
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