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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Estragole
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Accession:CHEBI:4867 term browser browse the term
Definition:An olefinic compound that has formula C10H12O.
Synonyms:related_synonym: 1-Allyl-4-methoxybenzene;   1-Methoxy-4-(2-propen-1-yl)benzene;   1-Methoxy-4-(2-propenyl)-Benzene;   1-Methoxy-4-(2-propenyl)benzene, 9CI;   1-Methoxy-4-prop-2-enylbenzene;   1-methoxy-4-(prop-2-en-1-yl)benzene;   3-(p-Methoxyphenyl)propene;   4-Allylanisole;   4-Allylmethoxybenzene;   4-Methoxyallylbenzene;   BENZENE,1-ALLYL,4-METHOXY METHYLCHAVICOL;   Benzene, 1-methoxy, 4-prop-2-enyl;   Chavicol methyl ether;   Chavicyl methyl ether;   Esdragol;   Esdragole;   Esdragon;   Estragol;   Estragol (methylchavicol);   FEMA 2411;   Formula=C10H12O;   InChI=1S/C10H12O/c1-3-4-9-5-7-10(11-2)8-6-9/h3,5-8H,1,4H2,2H3;   InChIKey=ZFMSMUAANRJZFM-UHFFFAOYSA-N;   Isoanethole;   Isoanthethole;   Methyl chavicole;   Methyl chavicole (estragole);   Methyl-Chavicol;   Methylchavicol;   O-Methyl-Chavicol;   P-Allylmethoxybenzene;   P-Allylphenyl methyl ether;   P-Methoxyallylbenzene;   Para-allylanisole (estragole);   SMILES=COc1ccc(CC=C)cc1;   Tarragon;   Terragon;   p-Allyl-Anisole;   p-Allylanisole
 xref: BPDB:1391;   CAS:140-67-0;   HMDB:HMDB0034121;   KEGG:C10452;   KNApSAcK:C00002740
 xref_mesh: MESH:C007633
 xref: PMID:10552889;   PMID:10995274;   PMID:11161012;   PMID:11884690;   PMID:12575134;   PMID:12617576;   PMID:15922374;   PMID:16826298;   PMID:18095647;   PMID:18266152;   PMID:18618386;   PMID:19167006;   PMID:19913108;   PMID:20552457;   PMID:21291237;   PMID:21469658;   PMID:21834250;   PMID:21922923;   PMID:21969960;   PMID:23010670;   PMID:23020916;   PMID:24421258


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Estragole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO estragole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:29191726 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Casp3 caspase 3 increases expression EXP estragole results in increased expression of CASP3 protein modified form CTD PMID:29054680 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccna2 cyclin A2 increases expression EXP estragole results in increased expression of CCNA2 mRNA CTD PMID:29054680 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 increases expression
multiple interactions
EXP
ISO
estragole results in increased expression of CCNB1 mRNA
flumequine promotes the reaction [estragole results in increased expression of CCNB1 mRNA]
CTD PMID:29054680, PMID:31029721 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 increases expression EXP estragole results in increased expression of CCND1 protein CTD PMID:29054680 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions
EXP
ISO
estragole results in increased expression of CCNE1 mRNA
[flumequine co-treated with estragole] results in increased expression of CCNE1 mRNA
CTD PMID:29054680, PMID:31029721 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Chek1 checkpoint kinase 1 increases expression EXP estragole results in increased expression of CHEK1 protein CTD PMID:29054680 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO estragole inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:29191726 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation
multiple interactions
increases expression
ISO CYP1A2 protein results in increased hydroxylation of estragole
[flumequine co-treated with estragole] results in increased expression of CYP1A2 mRNA
estragole results in increased expression of CYP1A2 mRNA
CTD PMID:19920071, PMID:31029721 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases hydroxylation ISO CYP2E1 protein results in increased hydroxylation of estragole CTD PMID:19920071 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation EXP estragole results in increased phosphorylation of GSK3B protein CTD PMID:29054680 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G H2ax H2A.X variant histone increases expression EXP estragole results in increased expression of H2AX protein modified form CTD PMID:29054680 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK1 protein CTD PMID:29054680 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK3 protein CTD PMID:29054680 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK8 protein CTD PMID:29054680 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK9 protein CTD PMID:29054680 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP estragole results in increased expression of PCNA protein CTD PMID:22576464, PMID:29054680 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha increases phosphorylation EXP estragole results in increased phosphorylation of PPP2CA protein CTD PMID:29054680 NCBI chr10:37,534,449...37,554,861
Ensembl chr10:37,535,871...37,554,664
JBrowse link
G Rad51 RAD51 recombinase increases expression EXP estragole results in increased expression of RAD51 protein CTD PMID:29054680 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation EXP estragole results in increased phosphorylation of SRC protein CTD PMID:29054680 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [flumequine co-treated with estragole] results in increased expression of TNF mRNA CTD PMID:31029721 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases phosphorylation EXP estragole results in increased phosphorylation of TP53 protein CTD PMID:29054680 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [flumequine co-treated with estragole] results in decreased expression of UGT1A1 mRNA CTD PMID:31029721 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      atom 19782
        nonmetal atom 19657
          carbon atom 19561
            organic molecular entity 19561
              olefinic compound 14455
                Estragole 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            olefinic compound 14455
                              Estragole 23
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.