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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Estragole
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Accession:CHEBI:4867 term browser browse the term
Definition:An olefinic compound that has formula C10H12O.
Synonyms:related_synonym: 1-Allyl-4-methoxybenzene;   1-Methoxy-4-(2-propen-1-yl)benzene;   1-Methoxy-4-(2-propenyl)-Benzene;   1-Methoxy-4-(2-propenyl)benzene, 9CI;   1-Methoxy-4-prop-2-enylbenzene;   1-methoxy-4-(prop-2-en-1-yl)benzene;   3-(p-Methoxyphenyl)propene;   4-Allylanisole;   4-Allylmethoxybenzene;   4-Methoxyallylbenzene;   BENZENE,1-ALLYL,4-METHOXY METHYLCHAVICOL;   Benzene, 1-methoxy, 4-prop-2-enyl;   Chavicol methyl ether;   Chavicyl methyl ether;   Esdragol;   Esdragole;   Esdragon;   Estragol;   Estragol (methylchavicol);   FEMA 2411;   Formula=C10H12O;   InChI=1S/C10H12O/c1-3-4-9-5-7-10(11-2)8-6-9/h3,5-8H,1,4H2,2H3;   InChIKey=ZFMSMUAANRJZFM-UHFFFAOYSA-N;   Isoanethole;   Isoanthethole;   Methyl chavicole;   Methyl chavicole (estragole);   Methyl-Chavicol;   Methylchavicol;   O-Methyl-Chavicol;   P-Allylmethoxybenzene;   P-Allylphenyl methyl ether;   P-Methoxyallylbenzene;   Para-allylanisole (estragole);   SMILES=COc1ccc(CC=C)cc1;   Tarragon;   Terragon;   p-Allyl-Anisole;   p-Allylanisole
 xref: BPDB:1391;   CAS:140-67-0;   HMDB:HMDB0034121;   KEGG:C10452;   KNApSAcK:C00002740
 xref_mesh: MESH:C007633
 xref: PMID:10552889;   PMID:10995274;   PMID:11161012;   PMID:11884690;   PMID:12575134;   PMID:12617576;   PMID:15922374;   PMID:16826298;   PMID:18095647;   PMID:18266152;   PMID:18618386;   PMID:19167006;   PMID:19913108;   PMID:20552457;   PMID:21291237;   PMID:21469658;   PMID:21834250;   PMID:21922923;   PMID:21969960;   PMID:23010670;   PMID:23020916;   PMID:24421258



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Estragole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO estragole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:29191726 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Casp3 caspase 3 increases expression EXP estragole results in increased expression of CASP3 protein modified form CTD PMID:29054680 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccna2 cyclin A2 increases expression EXP estragole results in increased expression of CCNA2 mRNA CTD PMID:29054680 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 increases expression
multiple interactions
EXP
ISO
estragole results in increased expression of CCNB1 mRNA
flumequine promotes the reaction [estragole results in increased expression of CCNB1 mRNA]
CTD PMID:29054680 PMID:31029721 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 increases expression EXP estragole results in increased expression of CCND1 protein CTD PMID:29054680 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 increases expression
multiple interactions
EXP
ISO
estragole results in increased expression of CCNE1 mRNA
[flumequine co-treated with estragole] results in increased expression of CCNE1 mRNA
CTD PMID:29054680 PMID:31029721 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Chek1 checkpoint kinase 1 increases expression EXP estragole results in increased expression of CHEK1 protein CTD PMID:29054680 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO estragole inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:29191726 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation
increases response to substance
multiple interactions
increases expression
ISO CYP1A2 protein results in increased hydroxylation of estragole
CYP1A2 protein results in increased susceptibility to estragole
[flumequine co-treated with estragole] results in increased expression of CYP1A2 mRNA
estragole results in increased expression of CYP1A2 mRNA
CTD PMID:19920071 PMID:31029721 PMID:32853702 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases hydroxylation ISO CYP2E1 protein results in increased hydroxylation of estragole CTD PMID:19920071 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation EXP estragole results in increased phosphorylation of GSK3B protein CTD PMID:29054680 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G H2ax H2A.X variant histone increases expression EXP estragole results in increased expression of H2AX protein modified form CTD PMID:29054680 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK1 protein CTD PMID:29054680 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK3 protein CTD PMID:29054680 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK8 protein CTD PMID:29054680 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation EXP estragole results in increased phosphorylation of MAPK9 protein CTD PMID:29054680 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP estragole results in increased expression of PCNA protein CTD PMID:22576464 PMID:29054680 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha increases phosphorylation EXP estragole results in increased phosphorylation of PPP2CA protein CTD PMID:29054680 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
JBrowse link
G Rad51 RAD51 recombinase increases expression EXP estragole results in increased expression of RAD51 protein CTD PMID:29054680 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation EXP estragole results in increased phosphorylation of SRC protein CTD PMID:29054680 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [flumequine co-treated with estragole] results in increased expression of TNF mRNA CTD PMID:31029721 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases phosphorylation EXP estragole results in increased phosphorylation of TP53 protein CTD PMID:29054680 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [flumequine co-treated with estragole] results in decreased expression of UGT1A1 mRNA CTD PMID:31029721 NCBI chr 9:88,801,344...88,808,465 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          carbon atom 19609
            organic molecular entity 19609
              olefinic compound 15714
                Estragole 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            olefinic compound 15714
                              Estragole 23
paths to the root