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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tranexamic acid
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Accession:CHEBI:48669 term browser browse the term
Definition:A monocarboxylic acid that has formula C8H15NO2.
Synonyms:related_synonym: Cyklokapron;   Formula=C8H15NO2;   InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-;   InChIKey=GYDJEQRTZSCIOI-LJGSYFOKSA-N;   SMILES=NC[C@H]1CC[C@@H](CC1)C(O)=O;   TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID;   Tranexamsaeure;   Tranhexamic acid;   acide tranexamique;   acido tranexamico;   acidum tranexamicum;   tranexmic acid;   trans-4-(aminomethyl)cyclohexanecarboxylic acid;   trans-Amcha;   trans-Tranexamic acid
 alt_id: CHEBI:32252;   CHEBI:40715;   CHEBI:48421
 xref: Beilstein:2207452;   CAS:1197-18-8;   DrugBank:DB00302;   Drug_Central:2713;   KEGG:D01136
 xref_mesh: MESH:D014148
 xref: PDBeChem:AMH;   Patent:NL6503605;   Patent:US3499925;   Wikipedia:Tranexamic_Acid

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tranexamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Tranexamic Acid inhibits the reaction [Rotenone results in increased expression of BAX protein] CTD PMID:19539006 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Tranexamic Acid inhibits the reaction [Rotenone results in decreased expression of BCL2 protein] CTD PMID:19539006 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:19539006 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein] CTD PMID:19539006 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA] CTD PMID:24633426 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Krt19 keratin 19 multiple interactions ISO Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of KRT19 protein] CTD PMID:24633426 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] CTD PMID:19539006 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA] CTD PMID:24633426 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TIMP1 mRNA] CTD PMID:24633426 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      application 19494
        pharmaceutical 19364
          drug 19364
            hematologic agent 4387
              tranexamic acid 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      carboxylic acid 18142
                                        monocarboxylic acid 17513
                                          cyclohexanecarboxylic acid 9
                                            tranexamic acid 9
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