CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: tranexamic acid
Accession: CHEBI:48669
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Definition: A monocarboxylic acid that has formula C8H15NO2.
Synonyms: related_synonym: Cyklokapron; Formula=C8H15NO2; InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-; InChIKey=GYDJEQRTZSCIOI-LJGSYFOKSA-N; SMILES=NC[C@H]1CC[C@@H](CC1)C(O)=O; TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID; Tranexamsaeure; Tranhexamic acid; acide tranexamique; acido tranexamico; acidum tranexamicum; tranexmic acid; trans-4-(aminomethyl)cyclohexanecarboxylic acid; trans-Amcha; trans-Tranexamic acid
alt_id: CHEBI:32252; CHEBI:40715; CHEBI:48421
xref: Beilstein:2207452; CAS:1197-18-8; DrugBank:DB00302; Drug_Central:2713; KEGG:D01136
xref_mesh: MESH:D014148
xref: PDBeChem:AMH; Patent:NL6503605; Patent:US3499925; Wikipedia:Tranexamic_Acid
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
Tranexamic Acid inhibits the reaction [Rotenone results in increased expression of BAX protein]
CTD
PMID:19539006
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
Tranexamic Acid inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]
CTD
PMID:19539006
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Casp3
caspase 3
multiple interactions
ISO
Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of and results in increased activity of CASP3 protein]
CTD
PMID:19539006
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Casp9
caspase 9
multiple interactions
ISO
Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein]
CTD
PMID:19539006
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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Col1a1
collagen type I alpha 1 chain
multiple interactions
ISO
Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA]
CTD
PMID:24633426
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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Krt19
keratin 19
multiple interactions
ISO
Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of KRT19 protein]
CTD
PMID:24633426
NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
Tranexamic Acid inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]
CTD
PMID:19539006
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Tgfb2
transforming growth factor, beta 2
multiple interactions
ISO
Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TGFB2 mRNA]
CTD
PMID:24633426
NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
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Timp1
TIMP metallopeptidase inhibitor 1
multiple interactions
ISO
Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TIMP1 mRNA]
CTD
PMID:24633426
NCBI chr X:1,364,771...1,369,451
Ensembl chr X:1,364,786...1,369,384
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