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Accession:CHEBI:48635 term browser browse the term
Definition:A meroterpenoid resulting from the formal condensation of the hydroxy group of fumagillol with the carboxylic acid group of (all-E)-deca-2,4,6,8-tetraenedioic acid. Originally isolated from the fungus Aspergillus fumigatus, it is used for the control of Nosema infection in honey bees.
Synonyms:exact_synonym: (2E,4E,6E,8E)-10-({(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl}oxy)-10-oxodeca-2,4,6,8-tetraenoic acid
 related_synonym: 2,4,6,8-decatetraenedioic acid, 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro(2,5)oct-6-yl ester;   Formula=C26H34O7;   Fugillin;   Fumidil;   InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24-,25+,26+/m1/s1;   InChIKey=NGGMYCMLYOUNGM-CSDLUJIJSA-N;   SMILES=[C@]1([C@]2(O[C@@]2(CC=C(C)C)[H])C)([H])[C@H](OC)[C@@H](CC[C@]13CO3)OC(/C=C/C=C/C=C/C=C/C(=O)O)=O;   fumagilina;   fumagilline;   fumagillinum
 alt_id: CHEBI:48534;   CHEBI:5189
 xref: Beilstein:5360220 "Beilstein";   CAS:23110-15-8 "ChemIDplus";   CAS:23110-15-8 "KEGG COMPOUND";   DrugBank:DB02640;   Drug_Central:3253 "DrugCentral";   KEGG:C09668;   KNApSAcK:C00003133;   LIPID_MAPS_instance:LMPR0103060003 "LIPID MAPS"
 xref_mesh: MESH:C026211
 xref: PMID:14514693 "Europe PMC";   PMID:14809278 "Europe PMC";   PMID:15723631 "Europe PMC";   PMID:23121865 "Europe PMC";   PMID:23488861 "Europe PMC";   PMID:23505365 "Europe PMC";   Patent:US2652356;   Patent:US2803586;   Reaxys:5360220 "Reaxys";   Wikipedia:Fumagillin

show annotations for term's descendants       view all columns           Sort by:
fumagillin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Metap1 methionyl aminopeptidase 1 JBrowse link 2 243,744,620 243,777,673 RGD:6480464
G Metap2 methionyl aminopeptidase 2 JBrowse link 7 34,762,241 34,789,456 RGD:6480464
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:6480464
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma JBrowse link 12 23,789,547 23,817,884 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        antimicrobial agent 17151
          fumagillin 5
            fumagillin-2-yl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      dicarboxylic acids and O-substituted derivatives 10167
                                        dicarboxylic acid 10160
                                          polyunsaturated dicarboxylic acid 50
                                            deca-2,4,6,8-tetraenedioic acid 5
                                              (all-E)-deca-2,4,6,8-tetraenedioic acid 5
                                                fumagillin 5
                                                  fumagillin-2-yl group 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.