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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:piperidinecarboxylate ester
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Accession:CHEBI:48630 term browser browse the term
Synonyms:related_synonym: piperidinecarboxylate esters



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pethidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D affects binding
increases hydrolysis
ISO Meperidine binds to CES1 protein
CES1 protein results in increased hydrolysis of Meperidine
CTD PMID:10381793 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Ces2h carboxylesterase 2H affects binding ISO Meperidine binds to CES2 protein CTD PMID:10381793 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
remifentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CASP3 protein modified form]]; MIR205 mRNA inhibits the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]; Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CASP3 protein modified form] CTD PMID:34078833 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
increases phosphorylation
EXP Ketamine inhibits the reaction [remifentanil results in increased phosphorylation of GRIN2B protein] CTD PMID:20042082 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO remifentanil affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Mir205 microRNA 205 multiple interactions EXP [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PINK1 protein]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CASP3 protein modified form]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MIR205 mRNA]]; [Antagomirs results in decreased expression of MIR205 mRNA] which results in increased susceptibility to Remifentanil; MIR205 mRNA inhibits the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of MIR205 mRNA]; Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MIR205 mRNA] CTD PMID:34078833 NCBI chr13:105,035,878...105,035,985
Ensembl chr13:105,035,878...105,035,985
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions EXP [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PINK1 protein]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in decreased expression of PINK1 protein]; Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PINK1 protein] CTD PMID:34078833 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions
affects localization
EXP Lidocaine inhibits the reaction [remifentanil affects the localization of PRKCG protein] CTD PMID:19955894 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    chemical entity 20058
      group 19984
        inorganic group 19469
          oxo group 18877
            organic oxo compound 18877
              carbonyl compound 18877
                carboxylic ester 15944
                  piperidinecarboxylate ester 8
                    (1R)-1,3-diphenylpropyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate 0
                    (1R)-1-cyclohexyl-3-phenylpropyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate 0
                    N-(tert-butoxycarbonyl)piperidin-2-one 0
                    anileridine 0
                    dimepiperate 0
                    diphenoxylate + 0
                    methyl 3-hydroxypiperidine-1-carboxylate 0
                    methyl 4-hydroxypiperidine-2-carboxylate 0
                    methyl 4-hydroxypiperidine-3-carboxylate 0
                    methyl 5-hydroxypiperidine-2-carboxylate 0
                    pethidine 2
                    remifentanil + 6
                    tert-butyl 4-(\{[4-(but-2-yn-1-ylamino)phenyl]sulfonyl\}methyl)-4-[(hydroxyamino)carbonyl]piperidine-1-carboxylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      carboxylic ester 15944
                                        piperidinecarboxylate ester 8
                                          (1R)-1,3-diphenylpropyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate 0
                                          (1R)-1-cyclohexyl-3-phenylpropyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate 0
                                          N-(tert-butoxycarbonyl)piperidin-2-one 0
                                          anileridine 0
                                          dimepiperate 0
                                          diphenoxylate + 0
                                          methyl 3-hydroxypiperidine-1-carboxylate 0
                                          methyl 4-hydroxypiperidine-2-carboxylate 0
                                          methyl 4-hydroxypiperidine-3-carboxylate 0
                                          methyl 5-hydroxypiperidine-2-carboxylate 0
                                          pethidine 2
                                          remifentanil + 6
                                          tert-butyl 4-(\{[4-(but-2-yn-1-ylamino)phenyl]sulfonyl\}methyl)-4-[(hydroxyamino)carbonyl]piperidine-1-carboxylate 0
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