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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzocycloheptapyridine
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Accession:CHEBI:48593 term browser browse the term
Synonyms:related_synonym: benzocycloheptapyridines

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azatadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh1 histamine receptor H 1 multiple interactions ISO azatadine binds to and results in decreased activity of HRH1 protein CTD PMID:2864258 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074 		JBrowse link
desloratadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export ISO ABCB1 protein results in increased export of desloratadine CTD PMID:12584158 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO desloratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril] CTD PMID:22095822 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects chemical synthesis ISO CYP2D6 protein affects the chemical synthesis of desloratadine CTD PMID:15932952 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO desloratadine results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Hrh1 histamine receptor H 1 affects binding ISO desloratadine binds to HRH1 protein CTD PMID:15482930 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO [montelukast co-treated with desloratadine] results in decreased expression of IL5 protein CTD PMID:15061398 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions		 ISO desloratadine results in decreased activity of KCNH2 protein
[desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine] results in decreased activity of KCNH2 protein		 CTD PMID:28551711 PMID:29143966 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO desloratadine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
lonafarnib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [Bortezomib co-treated with lonafarnib] results in decreased expression of AKT1 protein; [Bortezomib co-treated with lonafarnib] results in decreased expression of AKT1 protein modified form CTD PMID:16118318 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; lonafarnib promotes the reaction [Bortezomib results in increased cleavage of BCL2 protein modified form] CTD PMID:15090542 PMID:16118318 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein] CTD PMID:15090542 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO lonafarnib promotes the reaction [Bortezomib results in increased cleavage of BCL2L1 protein] CTD PMID:16118318 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] CTD PMID:15090542 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC3 protein] CTD PMID:15090542 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC5 protein] CTD PMID:15090542 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [lonafarnib co-treated with Bortezomib] results in increased cleavage of CASP3 protein CTD PMID:16118318 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [lonafarnib co-treated with Bortezomib] results in increased cleavage of CASP8 protein CTD PMID:16118318 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage		 ISO [lonafarnib co-treated with Bortezomib] results in increased cleavage of CASP9 protein
lonafarnib results in increased cleavage of CASP9 protein		 CTD PMID:16118318 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:15090542 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of CFLAR protein] CTD PMID:15090542 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions ISO [Bortezomib co-treated with lonafarnib] results in decreased expression of GSK3A protein modified form CTD PMID:16118318 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [Bortezomib co-treated with lonafarnib] results in decreased expression of GSK3B protein modified form CTD PMID:16118318 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased activity of HRAS protein] CTD PMID:15090542 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein] CTD PMID:21430599 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Lmna lamin A/C decreases farnesylation ISO lonafarnib results in decreased farnesylation of LMNA protein CTD PMID:16996129 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of MMP9 protein] CTD PMID:15090542 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO lonafarnib inhibits the reaction [Hydrogen Peroxide results in increased activity of NFKB1 protein]; lonafarnib inhibits the reaction [Okadaic Acid results in increased activity of NFKB1 protein]; lonafarnib inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NFKB1 protein]; lonafarnib inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15090542 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:15090542 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:15090542 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO lonafarnib results in decreased phosphorylation of and results in decreased activity of RB1 protein CTD PMID:12673674 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO lonafarnib inhibits the reaction [Hydrogen Peroxide results in increased activity of RELA protein]; lonafarnib inhibits the reaction [Okadaic Acid results in increased activity of RELA protein]; lonafarnib inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]; lonafarnib inhibits the reaction [TNF protein affects the localization of RELA protein]; lonafarnib inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:15090542 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rheb Ras homolog, mTORC1 binding decreases activity
multiple interactions		 ISO lonafarnib results in decreased activity of RHEB protein
[lonafarnib results in decreased activity of RHEB protein] which results in increased susceptibility to Cisplatin		 CTD PMID:20554106 NCBI chr 4:6,827,429...6,873,384
Ensembl chr 4:6,827,429...6,873,383 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO lonafarnib inhibits the reaction [TNF protein affects the localization of RELA protein]; lonafarnib inhibits the reaction [TNF protein results in increased activity of HRAS protein]; lonafarnib inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; lonafarnib inhibits the reaction [TNF protein results in increased activity of RELA protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of TRAF1 protein]; lonafarnib inhibits the reaction [TNF protein results in increased expression of XIAP protein]; lonafarnib inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]		 CTD PMID:15090542 PMID:21430599 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of TRAF1 protein] CTD PMID:15090542 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO lonafarnib inhibits the reaction [TNF protein results in increased expression of XIAP protein] CTD PMID:15090542 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000 		JBrowse link
Loratadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 ISO Loratadine results in decreased activity of ABCB11 protein
Loratadine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:23956101 PMID:24014644 PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
increases export		 ISO ABCB1A protein affects the susceptibility to Loratadine
ABCB1 protein results in increased export of Loratadine		 CTD PMID:12584158 PMID:15502009 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Loratadine CTD PMID:15502009 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Loratadine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Loratadine CTD PMID:22095822 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO Loratadine inhibits the reaction [ABCC2 protein results in increased export of Fosinopril] CTD PMID:22095822 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity ISO Loratadine analog results in decreased activity of ALOX5 protein CTD PMID:15482930 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303 		JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Loratadine results in decreased expression of AP1S1 mRNA CTD PMID:17567588 NCBI chr12:22,665,128...22,676,079
Ensembl chr12:22,665,112...22,676,075 		JBrowse link
G Ar androgen receptor increases expression ISO Loratadine results in increased expression of AR mRNA CTD PMID:16407038 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Loratadine results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases activity
multiple interactions		 ISO Loratadine results in increased cleavage of CASP3 protein
Loratadine results in increased activity of CASP3 protein
Dasatinib promotes the reaction [Loratadine results in increased activity of CASP3 protein]; midostaurin promotes the reaction [Loratadine results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Loratadine results in increased activity of CASP3 protein]		 CTD PMID:20570632 PMID:22700542 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO Loratadine results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Loratadine results in increased activity of CASP7 protein]		 CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO Loratadine results in increased cleavage of CASP8 protein CTD PMID:20570632 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO Loratadine results in increased cleavage of CASP9 protein CTD PMID:20570632 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Loratadine results in decreased activity of CYP2C8 protein CTD PMID:15601807 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 gene polymorphism affects the metabolism of Loratadine; CYP2D6 protein affects the metabolism of Loratadine CTD PMID:15932952 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO Loratadine analog results in decreased activity of CYP3A4 protein; Loratadine results in decreased activity of CYP3A4 protein CTD PMID:15482930 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Loratadine results in increased expression of ESR1 mRNA CTD PMID:16407038 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Loratadine results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Loratadine results in increased expression of GDPD3 mRNA CTD PMID:15342952 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150 		JBrowse link
G Hpn hepsin increases expression ISO Loratadine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967 		JBrowse link
G Hrh1 histamine receptor H 1 affects binding ISO Loratadine analog binds to HRH1 protein; Loratadine binds to HRH1 protein CTD PMID:15482930 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Loratadine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
affects activity		 ISO Loratadine results in decreased activity of KCNH2 protein
[desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with Loratadine] results in decreased activity of KCNH2 protein; Loratadine binds to and results in decreased activity of KCNH2 protein; Loratadine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Loratadine affects the activity of KCNH2 protein		 CTD PMID:9658196 PMID:10604956 PMID:11705456 PMID:16278312 PMID:21158687 PMID:29143966 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G LOC299277 similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B increases expression ISO Loratadine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 NCBI chr 6:127,871,895...127,888,287
Ensembl chr 6:127,872,666...127,886,540 		JBrowse link
G Lss lanosterol synthase increases expression ISO Loratadine results in increased expression of LSS mRNA CTD PMID:15342952 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Loratadine results in increased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Loratadine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524 		JBrowse link
G Rps6 ribosomal protein S6 decreases expression ISO Loratadine results in decreased expression of RPS6 protein modified form CTD PMID:20570632 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
Ensembl chr 5:105,197,857...105,200,148 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Loratadine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
Ensembl chr 4:155,408,233...155,631,856 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Loratadine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433 		JBrowse link
G Tagln transgelin decreases expression ISO Loratadine results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19770
      atom 19768
        nonmetal atom 19651
          nitrogen atom 18582
            nitrogen molecular entity 18582
              organonitrogen compound 18370
                organonitrogen heterocyclic compound 17526
                  benzocycloheptapyridine 60
                    (11S)-8-chloro-11-[1-(methylsulfonyl)piperidin-4-yl]-6-piperazin-1-yl-11H-benzo[5,6]cyclohepta[1,2-b]pyridine 0
                    4-\{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl\}piperidine-1-carboxamide + 28
                    8-chloro-3-methyl-11-[1-(4-pyridylacetyl)piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 0
                    Loratadine 32
                    azatadine + 1
                    desloratadine 8
                    rupatadine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  organic heteropolycyclic compound 17978
                                    organic heterotricyclic compound 14600
                                      benzocycloheptapyridine 60
                                        (11S)-8-chloro-11-[1-(methylsulfonyl)piperidin-4-yl]-6-piperazin-1-yl-11H-benzo[5,6]cyclohepta[1,2-b]pyridine 0
                                        4-\{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl\}piperidine-1-carboxamide + 28
                                        8-chloro-3-methyl-11-[1-(4-pyridylacetyl)piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 0
                                        Loratadine 32
                                        azatadine + 1
                                        desloratadine 8
                                        rupatadine 0
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