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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aminopiperidine
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Accession:CHEBI:48588 term browser browse the term
Synonyms:related_synonym: aminopiperidines


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linagliptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO Linagliptin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] CTD PMID:32567747 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Linagliptin inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA] CTD PMID:32567747 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases activity EXP Linagliptin results in decreased activity of DPP4 protein CTD PMID:22125632 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in decreased expression of HMOX1 protein]]; Linagliptin inhibits the reaction [letrozole results in decreased expression of HMOX1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in decreased expression of HMOX1 protein]] CTD PMID:28619389 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Linagliptin inhibits the reaction [Cisplatin results in increased expression of HSPA5 mRNA] CTD PMID:32567747 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il10 interleukin 10 multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in increased expression of IL10 protein]]; Linagliptin inhibits the reaction [letrozole results in increased expression of IL10 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in increased expression of IL10 protein]] CTD PMID:28619389 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO Linagliptin inhibits the reaction [Cuprizone results in increased expression of JAK2 protein modified form] CTD PMID:29864483 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in increased expression of LHB protein]]; Linagliptin inhibits the reaction [letrozole results in increased expression of LHB protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in increased expression of LHB protein]] CTD PMID:28619389 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mbp myelin basic protein multiple interactions ISO Linagliptin inhibits the reaction [Cuprizone results in decreased expression of MBP mRNA] CTD PMID:29864483 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]]; Linagliptin inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in decreased expression of NFE2L2 protein]] CTD PMID:28619389 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Olig2 oligodendrocyte transcription factor 2 multiple interactions ISO Linagliptin inhibits the reaction [Cuprizone results in decreased expression of OLIG2 mRNA] CTD PMID:29864483 NCBI chr11:31,389,514...31,392,890
Ensembl chr11:31,389,514...31,392,890
JBrowse link
G Plp1 proteolipid protein 1 multiple interactions ISO Linagliptin inhibits the reaction [Cuprizone results in decreased expression of PLP1 mRNA] CTD PMID:29864483 NCBI chr  X:107,494,326...107,511,355
Ensembl chr  X:107,496,072...107,511,348
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO Linagliptin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A protein] CTD PMID:32567747 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [Letrozole affects the localization of RELA protein]]; Linagliptin inhibits the reaction [Letrozole affects the localization of RELA protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [Letrozole affects the localization of RELA protein]]
Linagliptin inhibits the reaction [Cuprizone results in increased expression of RELA protein]
CTD PMID:28619389 PMID:29864483 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Linagliptin inhibits the reaction [Cuprizone results in decreased expression of SIRT1 mRNA] CTD PMID:29864483 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Linagliptin inhibits the reaction [Cuprizone results in increased expression of STAT3 protein modified form] CTD PMID:29864483 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in increased expression of TGFB1 protein]]; Linagliptin inhibits the reaction [letrozole results in increased expression of TGFB1 protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in increased expression of TGFB1 protein]] CTD PMID:28619389 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
indole-3-carbinol promotes the reaction [Linagliptin inhibits the reaction [letrozole results in increased expression of TNF protein]]; Linagliptin inhibits the reaction [letrozole results in increased expression of TNF protein]; Linagliptin promotes the reaction [indole-3-carbinol inhibits the reaction [letrozole results in increased expression of TNF protein]]
Linagliptin inhibits the reaction [Cuprizone results in increased expression of TNF protein]
CTD PMID:28619389 PMID:29864483 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19781
    chemical entity 19781
      atom 19779
        nonmetal atom 19659
          nitrogen atom 18625
            nitrogen molecular entity 18625
              organonitrogen compound 18367
                organonitrogen heterocyclic compound 17522
                  piperidines 7568
                    aminopiperidine 18
                      (2S,3R)-2-[(3S,6R)-3-amino-6-hydroxy-2-oxopiperidinyl]-3-hydroxybutanoic acid 0
                      (3R,4R)-1-\{6-[3-(methylsulfonyl)phenyl]pyrimidin-4-yl\}-4-(2,4,5-trifluorophenyl)piperidin-3-amine 0
                      (4-amino-2-\{[1-(methylsulfonyl)piperidin-4-yl]amino\}pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone 0
                      (4R,5R)-5-amino-1-[2-(1,3-benzodioxol-5-yl)ethyl]-4-(2,4,5-trifluorophenyl)piperidin-2-one 0
                      2-(\{8-[(3R)-3-aminopiperidin-1-yl]-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl\}methyl)benzonitrile 0
                      2-[(3S)-3-aminopiperidin-1-yl]-1-(2-cyanobenzyl)-5-methyl-4,6-dioxo-3,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-1-ium 0
                      2-[4-(\{2-[(2S,5R)-2-(aminomethyl)-5-ethynylpyrrolidin-1-yl]-2-oxoethyl\}amino)-4-methylpiperidin-1-yl]isonicotinic acid 0
                      4-(\{5-[(2-aminoethyl)amino]-2,4-dinitrophenyl\}amino)-TEMPO 0
                      4-[4-(4-fluorophenyl)-1-piperidin-4-yl-1H-imidazol-5-yl]pyrimidin-2-amine 0
                      4-\{1-methyl-2-piperidin-4-yl-4-[3-(trifluoromethyl)phenyl]-1H-imidazol-5-yl\}-N-[(1S)-1-phenylethyl]pyrimidin-2-amine 0
                      4-\{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino\}-N-ethylpiperidine-1-carboxamide 0
                      4-aminopiperidine-1-carboxylic acid 0
                      6-\{[1-(benzylsulfonyl)piperidin-4-yl]amino\}-3-(carboxymethoxy)thieno[3,2-b][1]benzothiophene-2-carboxylic acid 0
                      AZD3463 0
                      \{[5-(3-\{[1-(benzylsulfonyl)piperidin-4-yl]amino\}phenyl)-4-bromo-2-(2H-tetrazol-5-yl)thiophen-3-yl]oxy\}acetic acid 0
                      crenolanib 0
                      linagliptin 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic molecule 19510
                              organic cyclic compound 19337
                                organic heterocyclic compound 18550
                                  organic heteromonocyclic compound 16990
                                    piperidines 7568
                                      aminopiperidine 18
                                        (2S,3R)-2-[(3S,6R)-3-amino-6-hydroxy-2-oxopiperidinyl]-3-hydroxybutanoic acid 0
                                        (3R,4R)-1-\{6-[3-(methylsulfonyl)phenyl]pyrimidin-4-yl\}-4-(2,4,5-trifluorophenyl)piperidin-3-amine 0
                                        (4-amino-2-\{[1-(methylsulfonyl)piperidin-4-yl]amino\}pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone 0
                                        (4R,5R)-5-amino-1-[2-(1,3-benzodioxol-5-yl)ethyl]-4-(2,4,5-trifluorophenyl)piperidin-2-one 0
                                        2-(\{8-[(3R)-3-aminopiperidin-1-yl]-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl\}methyl)benzonitrile 0
                                        2-[(3S)-3-aminopiperidin-1-yl]-1-(2-cyanobenzyl)-5-methyl-4,6-dioxo-3,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-1-ium 0
                                        2-[4-(\{2-[(2S,5R)-2-(aminomethyl)-5-ethynylpyrrolidin-1-yl]-2-oxoethyl\}amino)-4-methylpiperidin-1-yl]isonicotinic acid 0
                                        4-(\{5-[(2-aminoethyl)amino]-2,4-dinitrophenyl\}amino)-TEMPO 0
                                        4-[4-(4-fluorophenyl)-1-piperidin-4-yl-1H-imidazol-5-yl]pyrimidin-2-amine 0
                                        4-\{1-methyl-2-piperidin-4-yl-4-[3-(trifluoromethyl)phenyl]-1H-imidazol-5-yl\}-N-[(1S)-1-phenylethyl]pyrimidin-2-amine 0
                                        4-\{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino\}-N-ethylpiperidine-1-carboxamide 0
                                        4-aminopiperidine-1-carboxylic acid 0
                                        6-\{[1-(benzylsulfonyl)piperidin-4-yl]amino\}-3-(carboxymethoxy)thieno[3,2-b][1]benzothiophene-2-carboxylic acid 0
                                        AZD3463 0
                                        \{[5-(3-\{[1-(benzylsulfonyl)piperidin-4-yl]amino\}phenyl)-4-bromo-2-(2H-tetrazol-5-yl)thiophen-3-yl]oxy\}acetic acid 0
                                        crenolanib 0
                                        linagliptin 18
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