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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:estazolam
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Accession:CHEBI:4858 term browser browse the term
Definition:A triazolo[4,3-a][1,4]benzodiazepine having a phenyl group at position 6 and a chloro substituent at position 8. A short-acting benzodiazepine with general properties similar to diazepam, it is given by mouth as a hypnotic in the short-term management of insomnia.
Synonyms:exact_synonym: 8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
 related_synonym: 8-chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine;   Formula=C16H11ClN4;   InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2;   InChIKey=CDCHDCWJMGXXRH-UHFFFAOYSA-N;   SMILES=Clc1ccc-2c(c1)C(=NCc1nncn-21)c1ccccc1;   estazolamum
 alt_id: CHEBI:149847
 xref: Beilstein:1220868;   CAS:29975-16-4;   DrugBank:DB01215;   Drug_Central:1056;   KEGG:D00311
 xref_mesh: MESH:D004949
 xref: PMID:7154007;   Patent:DE1955349;   Patent:DE2012190;   Patent:DE2114441;   Patent:US3701782;   Wikipedia:Estazolam


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estazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Estazolam results in decreased activity of AKR1C2 protein CTD PMID:11995921 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Estazolam results in decreased activity of AKR1C3 protein CTD PMID:11995921 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases hydroxylation ISO CYP3A4 protein results in increased hydroxylation of Estazolam CTD PMID:16012077 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Estazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Estazolam inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        biophysical role 12688
          membrane transport modulator 12487
            GABA modulator 4662
              estazolam 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic molecule 19497
                              organic cyclic compound 19321
                                organic heterocyclic compound 18512
                                  heteroarene 16520
                                    monocyclic heteroarene 13364
                                      azole 12538
                                        triazoles 3652
                                          estazolam 5
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