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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:radical scavenger
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Accession:CHEBI:48578 term browser browse the term
Definition:A role played by a substance that can react readily with, and thereby eliminate, radicals.
Synonyms:related_synonym: free radical scavengers;   free-radical scavenger



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allopurinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLN phospholamban affects expression EXP Allopurinol affects the expression of PLN mRNA; Allopurinol affects the expression of PLN protein; Allopurinol affects the expression of PLN protein modified form CTD PMID:17071724 NCBI chr 1:58,579,095...58,590,541
Ensembl chr 1:58,579,145...58,590,535
JBrowse link
G SLC8A1 solute carrier family 8 member A1 affects expression EXP Allopurinol affects the expression of SLC8A1 mRNA; Allopurinol affects the expression of SLC8A1 protein CTD PMID:17071724 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700
JBrowse link
diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C18 cytochrome P450 2C21 increases hydroxylation EXP CYP2C19 protein results in increased hydroxylation of Diclofenac CTD PMID:15677349 NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587
JBrowse link
G CYP2C41 cytochrome P450 2C41 affects metabolic processing EXP CYP2C9 protein affects the metabolism of Diclofenac CTD PMID:15801540
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Diclofenac results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
edaravone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SELP selectin P decreases expression EXP Edaravone results in decreased expression of SELP protein CTD PMID:16041266 NCBI chr 7:28,956,428...28,997,266
Ensembl chr 7:28,958,486...28,996,313
JBrowse link
flufenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE6 copine 6 decreases activity EXP Flufenamic Acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
ibuprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Ibuprofen results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP Ibuprofen results in increased expression of PTGS2 protein CTD PMID:16105799 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
luteolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL17 C-C motif chemokine ligand 17 multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of CCL17 promoter CTD PMID:33763461 NCBI chr 2:59,001,463...59,014,347
Ensembl chr 2:59,001,464...59,005,230
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of CCL2 promoter CTD PMID:33763461 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G IL13 interleukin 13 multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA] CTD PMID:33763461 NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388
JBrowse link
G IL31 interleukin 31 multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA] CTD PMID:33763461 NCBI chr26:7,173,151...7,175,195
Ensembl chr26:7,172,451...7,175,195
JBrowse link
G IL31RA interleukin 31 receptor A multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of IL31RA promoter CTD PMID:33763461 NCBI chr 2:43,113,194...43,198,200
Ensembl chr 2:43,144,071...43,193,293
JBrowse link
G IL4 interleukin 4 multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA] CTD PMID:33763461 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534
JBrowse link
G TSLP thymic stromal lymphopoietin multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of TSLP promoter CTD PMID:33763461 NCBI chr 3:1,502,469...1,507,696
Ensembl chr 3:1,503,188...1,507,696
JBrowse link
N-acetyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
JBrowse link
nitric oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 increases activity EXP Nitric Oxide deficiency results in increased activity of KNG1 protein modified form CTD PMID:10805402 NCBI chr34:19,288,629...19,318,096
Ensembl chr34:19,287,109...19,318,081
JBrowse link
G WT1 WT1 transcription factor multiple interactions EXP [Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA CTD PMID:21443142 NCBI chr18:35,099,660...35,148,767
Ensembl chr18:35,103,934...35,148,000
JBrowse link
quercetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] CTD PMID:15266218 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G CPNE6 copine 6 decreases activity EXP Quercetin results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
G HSP70 heat shock protein 70 decreases expression EXP Quercetin results in decreased expression of HSP70 protein CTD PMID:17009600 NCBI chr12:1,285,282...1,287,670 JBrowse link
taurocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B2 solute carrier organic anion transporter family member 1B2 increases transport EXP SLCO1B3 protein results in increased transport of Taurocholic Acid CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
JBrowse link

Term paths to the root
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  CHEBI ontology 494
    role 501
      chemical role 420
        antioxidant 43
          radical scavenger 24
            (+)-gallocatechin + 0
            (-)-gallocatechin + 0
            (2S)-5,7,3',5'-tetrahydroxyflavanone-7-O-beta-D-glucopyranoside 0
            (E)-5-hydroxy-6-(3-methylbut-2-enyl)-2-(pent-1-enyl)benzofuran-4-carbaldehyde 0
            1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose 0
            10H-phenothiazine + 0
            10H-phenoxazine 0
            2',6'-dihydroxy-4'-methoxydihydrochalcone 0
            2-O-caffeoyl maslinic acid 0
            2-naphthol + 0
            4-(2-iodacetamido)-TEMPO 0
            4-acetamido-TEMPO 0
            4-amino-TEMPO + 0
            4-carboxy-TEMPO 0
            4-hydroxy-TEMPO + 0
            4-hydroxy-TEMPO benzoate 0
            4-maleimido-TEMPO 0
            4-methoxy-TEMPO 0
            4-oxo-TEMPO 0
            5,6,7,4'-tetrahydroxyflavonol-3-O-rutinoside 0
            6,6'-bieckol 0
            7,8-diacetoxy-4-methylcoumarin 0
            8-lavandulylkaempferol 0
            Echinacea extract 0
            N,N-dimethylethanolamine + 0
            N-acetyl-L-cysteine + 5
            PROXYL + 0
            S-allylsulfenic acid 0
            TEMPO + 0
            Trolox 0
            XJB-5-131 0
            albibrissinoside A 0
            allopurinol + 2
            alpha-(4-hydroxyphenyl)-N-tert-butylnitrone 0
            alpha-benzoyloxypaeoniflorin 0
            ansaetherone 0
            anthrone + 0
            ardisiphenol A 0
            ardisiphenol B 0
            ardisiphenol C 0
            astilbin 0
            baicalein + 0
            baicalein(1-) 0
            bellidin + 0
            bendazac 0
            benthophoenin 0
            benzastatin C 0
            caffeoylglycolic acid methyl ester 0
            calabricoside A 0
            calabricoside B 0
            camellianoside 0
            carboxy-PTIO 0
            chaetopyranin 0
            crassifogenin C 0
            cratoxylumxanthone D 0
            cudranian 1 0
            cudranian 2 0
            cupressuflavone 0
            curcumin + 0
            curtisian A 0
            curtisian B 0
            curtisian C 0
            curtisian D 0
            cyathusal A 0
            cyathusal B 0
            cyathusal C 0
            daedalin A 0
            dendrocandin C 0
            dendrocandin D 0
            dendrocandin E 0
            dieckol 0
            dimethyl sulfoxide + 0
            diphenylamine + 3
            ebselen 0
            eckstolonol 0
            edaravone 1
            eriodictyol 7-O-beta-D-glucopyranoside 0
            erylatissin A 0
            erylatissin B 0
            erylatissin C 0
            eugenol + 0
            ferrostatin-1 + 0
            flavaspidic acid PB 0
            formobactin 0
            ginsenoside Rb1 0
            gliclazide 0
            hydroxysafflor yellow A 0
            hydroxyurea 0
            ibuprofen + 2
            isonymphaeol B 0
            isoorientin + 0
            isotetrahydroauroglaucin 0
            kaempferol 7-O-beta-D-glucopyranoside 0
            kaempferol-3-rutinoside 0
            ladanein 0
            liproxstatin-1 0
            lobarin 0
            luteolin + 7
            madhucoside A 0
            madhucoside B 0
            maritimetin 0
            matteucinol + 0
            melatonin + 0
            methyl brevifolincarboxylate 0
            nigerloxin 0
            nitric oxide 2
            nymphaeol A 0
            nymphaeol B 0
            nymphaeol C 0
            oleuropein + 0
            oriciacridone C 0
            oriciacridone F 0
            orobol + 0
            ovothiol A 0
            ovothiol B 0
            ovothiol C 0
            paxanthonin + 0
            penicitrinol B 0
            pennicitrinone C 0
            potassium 2-(4-carboxylatophenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide 0
            potassium iodide 0
            pramipexole 0
            propofol + 0
            pterostilbene 0
            pyridoxatin 0
            pyrrolidine dithiocarbamate 0
            quercetin + 3
            quercetin 3,4'-di-O-beta-D-glucoside 0
            salumycin 0
            sigmoidin A 0
            sigmoidin B 0
            silychristin 0
            sugiol + 0
            surugapyrrole A 0
            surugapyrrole B 0
            tanariflavanone C 0
            tanariflavanone D 0
            taurine + 1
            trans-resveratrol + 0
            tricin 7-O-beta-D-glucoside 0
            xyloketal B 0
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