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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dopaminergic agent
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Accession:CHEBI:48560 term browser browse the term
Definition:A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
Synonyms:related_synonym: dopamine agent;   dopamine agents;   dopamine drug;   dopamine drugs;   dopaminergic agents



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chlorpromazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAO D-amino acid oxidase decreases activity EXP Chlorpromazine results in decreased activity of DAO protein CTD PMID:18615285 NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,929,215...41,950,633
JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases oxidation EXP FMO1 protein results in increased oxidation of Chlorpromazine CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,812,103...63,895,077
JBrowse link
cocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases expression
multiple interactions
EXP Cocaine results in increased expression of EDN1 protein
1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]; Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]
CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
haloperidol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 multiple interactions EXP Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein] CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
mesulergine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR2C 5-hydroxytryptamine receptor 2C affects binding
multiple interactions
EXP mesulergine binds to HTR2C protein
8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [mesulergine binds to HTR2C protein]
CTD PMID:11927170 NCBI chr  X:94,053,415...94,313,352
Ensembl chr  X:94,053,456...94,313,356
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 932
    role 871
      biological role 871
        pharmacological role 392
          neurotransmitter agent 152
            dopaminergic agent 4
              (S)-amphetamine + 0
              7alpha-hydroxypregnenolone 0
              L-dopa + 0
              amantadine 0
              amantadine sulfate 0
              amphetamine + 0
              auraptene 0
              benserazide 0
              benserazide hydrochloride 0
              carbidopa 0
              carbidopa (anhydrous) + 0
              dopamine + 0
              dopamine agonist + 1
              dopamine uptake inhibitor + 1
              dopaminergic antagonist + 3
              memantine 0
              memantine hydrochloride 0
              phentermine + 0
              selegiline hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 932
    role 871
      application 704
        pharmaceutical 646
          drug 646
            neurotransmitter agent 152
              dopaminergic agent 4
                (S)-amphetamine + 0
                7alpha-hydroxypregnenolone 0
                L-dopa + 0
                amantadine 0
                amantadine sulfate 0
                amphetamine + 0
                auraptene 0
                benserazide 0
                benserazide hydrochloride 0
                carbidopa 0
                carbidopa (anhydrous) + 0
                dopamine + 0
                dopamine agonist + 1
                dopamine uptake inhibitor + 1
                dopaminergic antagonist + 3
                memantine 0
                memantine hydrochloride 0
                phentermine + 0
                selegiline hydrochloride 0
paths to the root