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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:beta-adrenergic drug
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Accession:CHEBI:48540 term browser browse the term
Definition:Any of the drugs that act on beta-adrenergic receptors.
Synonyms:related_synonym: beta-adrenergic drugs


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carvedilol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH5 cadherin 5 decreases expression
increases expression		 EXP Carvedilol results in decreased expression of CDH5 mRNA
Carvedilol results in increased expression of CDH5 protein		 CTD PMID:16824628 NCBI chr 6:27,108,560...27,142,145
Ensembl chr 6:27,108,597...27,142,177 		JBrowse link
G CTNNB1 catenin beta 1 decreases expression
increases expression		 EXP Carvedilol results in decreased expression of CTNNB1 mRNA
Carvedilol results in increased expression of CTNNB1 protein		 CTD PMID:16824628 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311 		JBrowse link
G EDN1 endothelin 1 decreases expression
multiple interactions		 EXP Carvedilol results in decreased expression of EDN1 protein
Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein]		 CTD PMID:18840580 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G JUP junction plakoglobin increases expression
decreases expression		 EXP Carvedilol results in increased expression of JUP protein
Carvedilol results in decreased expression of JUP mRNA		 CTD PMID:16824628 NCBI chr12:20,902,395...20,931,208
Ensembl chr12:20,901,396...20,931,210 		JBrowse link
dobutamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HK2 hexokinase 2 decreases expression EXP Dobutamine results in decreased expression of HK2 protein CTD PMID:19944370 NCBI chr 3:68,155,656...68,231,187
Ensembl chr 3:68,153,835...68,231,615 		JBrowse link
G NOS2 nitric oxide synthase 2 affects response to substance EXP NOS2 protein affects the susceptibility to Dobutamine CTD PMID:20141602 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G PYGM glycogen phosphorylase, muscle associated decreases expression EXP Dobutamine results in decreased expression of PYGM protein CTD PMID:19944370 NCBI chr 2:7,409,330...7,421,256
Ensembl chr 2:7,409,116...7,421,254 		JBrowse link
icatibant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 decreases activity EXP icatibant results in decreased activity of KNG1 protein modified form CTD PMID:7890486 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5164
    role 5131
      biological role 5131
        pharmacological role 645
          neurotransmitter agent 205
            adrenergic agent 28
              beta-adrenergic drug 8
                beta-adrenergic agonist + 3
                beta-adrenergic antagonist + 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 5164
    role 5131
      application 908
        pharmaceutical 742
          drug 742
            neurotransmitter agent 205
              adrenergic agent 28
                beta-adrenergic drug 8
                  beta-adrenergic agonist + 3
                  beta-adrenergic antagonist + 5
paths to the root