Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:beta-adrenergic drug
go back to main search page
Accession:CHEBI:48540 term browser browse the term
Definition:Any of the drugs that act on beta-adrenergic receptors.
Synonyms:related_synonym: beta-adrenergic drugs


show annotations for term's descendants           Sort by:
(R)-adrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPPA natriuretic peptide A affects abundance EXP NPPA protein affects the abundance of Epinephrine CTD PMID:2951327 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
atenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin multiple interactions EXP Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] CTD PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
carvedilol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 decreases activity EXP Carvedilol results in decreased activity of CASP3 protein CTD PMID:12875697 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505 		JBrowse link
G FAS Fas cell surface death receptor decreases expression EXP Carvedilol results in decreased expression of FAS CTD PMID:12875697 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321 		JBrowse link
G FASLG Fas ligand decreases expression EXP Carvedilol results in decreased expression of FASLG CTD PMID:12875697 NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224 		JBrowse link
G NT5E 5'-nucleotidase ecto increases activity EXP Carvedilol results in increased activity of NT5E protein CTD PMID:15148268 NCBI chr12:45,491,028...45,520,019
Ensembl chr12:45,491,733...45,518,405 		JBrowse link
G RYR2 ryanodine receptor 2 multiple interactions EXP Carvedilol results in decreased oxidation of and results in increased stability of RYR2 protein CTD PMID:17448375 NCBI chr 4:2,371,868...2,908,132
Ensembl chr 4:2,373,114...2,907,875 		JBrowse link
isoprenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin multiple interactions
increases activity		 EXP Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; xibenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] CTD PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
metoprolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein CTD PMID:18820026 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388 		JBrowse link
G CYP2D15 cytochrome P450 family 2 subfamily D member 15 affects metabolic processing EXP CYP2D15 affects the metabolism of Metoprolol CTD PMID:7786018 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298 		JBrowse link
G EGR1 early growth response 1 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein CTD PMID:18820026 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575 		JBrowse link
G GATA4 GATA binding protein 4 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein CTD PMID:18820026 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989 		JBrowse link
G NAB1 NGFI-A binding protein 1 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein CTD PMID:18820026 NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein CTD PMID:18820026 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700 		JBrowse link
pindolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin multiple interactions EXP Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] CTD PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
propranolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine CTD PMID:2884805 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298 		JBrowse link
G NPPA natriuretic peptide A increases expression EXP Propranolol results in increased expression of NPPA protein CTD PMID:2566282 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
G REN renin multiple interactions
decreases activity		 EXP Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]
Propranolol results in decreased activity of REN protein		 CTD PMID:2566282 PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
G VIP vasoactive intestinal peptide decreases expression EXP Propranolol results in decreased expression of VIP protein CTD PMID:2566282 NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 501
    role 501
      biological role 501
        pharmacological role 166
          neurotransmitter agent 101
            adrenergic agent 27
              beta-adrenergic drug 15
                beta-adrenergic agonist + 2
                beta-adrenergic antagonist + 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 501
    role 501
      application 457
        pharmaceutical 452
          drug 452
            neurotransmitter agent 101
              adrenergic agent 27
                beta-adrenergic drug 15
                  beta-adrenergic agonist + 2
                  beta-adrenergic antagonist + 15
paths to the root