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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:beta-adrenergic drug
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Accession:CHEBI:48540 term browser browse the term
Definition:Any of the drugs that act on beta-adrenergic receptors.
Synonyms:related_synonym: beta-adrenergic drugs


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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases export
EXP [Epinephrine co-treated with [verlukast results in decreased activity of ABCC1 protein]] results in increased abundance of Glutathione Disulfide; [verlukast results in decreased activity of ABCC1 protein] which promotes the reaction and affects the abundance of Epinephrine metabolite
ABCC1 protein results in increased export of Epinephrine metabolite
CTD PMID:19053318 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Aco2 aconitase 2 increases expression EXP Epinephrine results in increased expression of ACO2 protein CTD PMID:19464573 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Actn1 actinin, alpha 1 increases expression EXP Epinephrine results in increased expression of ACTN1 protein CTD PMID:19464573 NCBI chr 6:103,376,557...103,470,497
Ensembl chr 6:103,375,799...103,470,555
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions
increases activity
affects binding
EXP
ISO
[Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium; Epinephrine binds to and results in increased activity of ADRA1A protein
Epinephrine results in increased activity of ADRA1A protein
[Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1A protein; Epinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]
Epinephrine binds to ADRA1A protein
CTD PMID:8183249, PMID:15306222, PMID:15672411, PMID:20030735 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions
increases activity
ISO [Epinephrine binds to and results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1B protein; Epinephrine inhibits the reaction [ADRA1B protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium] CTD PMID:15306222, PMID:20030735 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding
increases activity
multiple interactions
ISO Epinephrine binds to ADRA1D protein
Epinephrine results in increased activity of ADRA1D protein
[Epinephrine binds to and results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; Carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1D protein; Epinephrine inhibits the reaction [ADRA1D protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]
CTD PMID:8183249, PMID:15306222, PMID:20030735 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Adra2a adrenoceptor alpha 2A increases activity
multiple interactions
EXP
ISO
Epinephrine results in increased activity of ADRA2A protein
Epinephrine promotes the reaction [GNB2 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNB4 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG12 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG2 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG3 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG4 protein binds to ADRA2A protein]
[Epinephrine binds to and results in increased activity of ADRA2A protein] which results in increased abundance of Calcium; ADRA2A promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2A protein; Epinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]
CTD PMID:17341653, PMID:17680988, PMID:20030735, PMID:30737458 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO [Epinephrine binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium; ADRA2B promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2B protein; Epinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan] CTD PMID:17680988, PMID:20030735 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987
JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions ISO [Epinephrine binds to and results in increased activity of ADRA2C protein] which results in increased abundance of Calcium; ADRA2C promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2C protein; Epinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan] CTD PMID:17680988, PMID:20030735 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions ISO
EXP
[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased activity of Epinephrine
Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]
[Epinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP; Epinephrine binds to and results in increased activity of ADRB1 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]
CTD PMID:8096834, PMID:12010770, PMID:14730417 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
affects response to substance
increases activity
ISO
EXP
[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; carvedilol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Epinephrine binds to and results in increased activity of ADRB2 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Epinephrine promotes the reaction [GRK2 protein results in increased phosphorylation of ADRB2 protein]; Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein]; Epinephrine results in increased phosphorylation of and results in increased localization of ADRB2 protein; ICI 118551 inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]
[Epinephrine results in increased activity of ADRB2 protein] which results in increased secretion of Histamine
ADRB2 affects the susceptibility to Epinephrine
CTD PMID:1389726, PMID:11164953, PMID:12920204, PMID:14722251, PMID:14730417, PMID:16026475, PMID:16225854 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions EXP
ISO
Epinephrine binds to and results in increased activity of ADRB3 protein
[Epinephrine binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Epinephrine binds to and results in increased activity of ADRB3 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB3 protein]
CTD PMID:1682311, PMID:7815362, PMID:14730417 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Ak2 adenylate kinase 2 decreases expression
multiple interactions
EXP Epinephrine results in decreased expression of AK2 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of AK2 protein
CTD PMID:19464573 NCBI chr 5:147,185,474...147,204,050
Ensembl chr 5:147,185,474...147,204,050
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [Epinephrine co-treated with INS protein] results in increased phosphorylation of AKT1 protein CTD PMID:32305330 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aoc1 amine oxidase, copper containing 1 multiple interactions
increases activity
EXP Cycloheximide inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]; Timolol inhibits the reaction [Epinephrine results in increased activity of AOC1 protein] CTD PMID:2860926 NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584
JBrowse link
G Aqp7 aquaporin 7 affects localization
multiple interactions
increases expression
ISO Epinephrine affects the localization of AQP7 protein
INS1 inhibits the reaction [Epinephrine results in increased expression of AQP7 mRNA]
CTD PMID:10777495 NCBI chr 5:57,358,297...57,372,332
Ensembl chr 5:57,358,327...57,372,239
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression EXP Epinephrine results in increased expression of ATP5F1A protein CTD PMID:19464573 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Bmp2 bone morphogenetic protein 2 decreases expression ISO Epinephrine results in decreased expression of BMP2 mRNA; Epinephrine results in decreased expression of BMP2 protein CTD PMID:31520687 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G C1qbp complement C1q binding protein multiple interactions
increases expression
EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of C1QBP protein
Epinephrine results in increased expression of C1QBP protein
CTD PMID:19464573 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Calca calcitonin-related polypeptide alpha increases abundance EXP CALCA protein results in increased abundance of Epinephrine CTD PMID:8058111 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Caly calcyon neuron-specific vesicular protein decreases secretion ISO CALY protein results in decreased secretion of Epinephrine CTD PMID:30753204 NCBI chr 1:212,537,851...212,549,040
Ensembl chr 1:212,537,848...212,549,477
JBrowse link
G Car2 carbonic anhydrase 2 increases expression ISO Epinephrine results in increased expression of CA2 mRNA CTD PMID:12729923 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
Atenolol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]; carvedilol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]
Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein]
CTD PMID:10728402, PMID:19135123 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases response to substance ISO CAT results in decreased susceptibility to Epinephrine CTD PMID:25172298 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 mRNA]; Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 protein]; Propranolol inhibits the reaction [Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 protein]]
Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Epinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Epinephrine inhibits the reaction [Thioglycolates results in increased secretion of CCL3 protein]
CTD PMID:9863660, PMID:12538206 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; 2-methoxyidazoxan inhibits the reaction [Epinephrine results in increased expression of CCND1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]
Epinephrine results in increased expression of CCND1 mRNA; Epinephrine results in increased expression of CCND1 protein
ADRA2A promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased expression of CCND1 protein]
CTD PMID:17680988, PMID:26964897 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO Epinephrine results in decreased expression of CEBPB protein CTD PMID:31520687 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine] CTD PMID:17498763 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Comt catechol-O-methyltransferase increases methylation
multiple interactions
ISO
EXP
COMT protein results in increased methylation of Epinephrine
[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]
[tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine
CTD PMID:8821542, PMID:10064789, PMID:11160877, PMID:11248589 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
ISO
EXP
ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; Dietary Fats promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; Epinephrine promotes the reaction [Dietary Fats results in increased phosphorylation of CREB1 protein]; Ketoconazole inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]
CTD PMID:17680988, PMID:22496244 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases abundance
EXP corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein affects the abundance of Epinephrine]
CRH results in increased abundance of Epinephrine
CTD PMID:1320258 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Csk C-terminal Src kinase multiple interactions ISO CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]; Isoproterenol inhibits the reaction [CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]] CTD PMID:1699227 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303
JBrowse link
G Ctnnb1 catenin beta 1 increases phosphorylation
multiple interactions
EXP Epinephrine results in increased phosphorylation of CTNNB1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]
CTD PMID:26964897 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsk cathepsin K increases expression ISO Epinephrine results in increased expression of CTSK mRNA CTD PMID:12729923 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression
EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of CYCS protein
Epinephrine results in increased expression of CYCS protein
CTD PMID:19464573 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Dbh dopamine beta-hydroxylase affects abundance ISO DBH gene polymorphism affects the abundance of Epinephrine CTD PMID:16163519 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Des desmin multiple interactions
decreases expression
EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DES protein
Epinephrine results in decreased expression of DES protein
CTD PMID:19464573 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DLAT protein CTD PMID:19464573 NCBI chr 8:55,062,549...55,087,832
Ensembl chr 8:55,062,551...55,087,832
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein CTD PMID:19464573 NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057
JBrowse link
G Epha4 Eph receptor A4 increases phosphorylation ISO Epinephrine results in increased phosphorylation of EPHA4 protein CTD PMID:22273509 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
JBrowse link
G Etfb electron transfer flavoprotein subunit beta multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ETFB protein CTD PMID:19464573 NCBI chr 1:98,472,776...98,486,940
Ensembl chr 1:98,472,745...98,486,976
JBrowse link
G Fabp3 fatty acid binding protein 3 affects expression
multiple interactions
EXP Epinephrine affects the expression of FABP3 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of FABP3 protein
CTD PMID:19464573 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO Atenolol inhibits the reaction [Epinephrine results in increased expression of FAS protein]; carvedilol inhibits the reaction [Epinephrine results in increased expression of FAS protein] CTD PMID:10728402 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO Atenolol inhibits the reaction [Epinephrine results in increased expression of FASLG protein]; carvedilol inhibits the reaction [Epinephrine results in increased expression of FASLG protein] CTD PMID:10728402 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fh fumarate hydratase increases expression EXP Epinephrine results in increased expression of FH protein CTD PMID:19464573 NCBI chr13:93,651,486...93,677,371
Ensembl chr13:93,651,484...93,677,377
JBrowse link
G Foxo1 forkhead box O1 decreases expression ISO Epinephrine results in decreased expression of FOXO1 protein CTD PMID:31520687 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Gnb2 G protein subunit beta 2 multiple interactions ISO Epinephrine promotes the reaction [GNB2 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr12:22,229,079...22,234,096
Ensembl chr12:22,229,079...22,234,096
JBrowse link
G Gnb4 G protein subunit beta 4 multiple interactions ISO Epinephrine promotes the reaction [GNB4 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr 2:118,978,965...119,007,877
Ensembl chr 2:118,978,973...119,007,835
JBrowse link
G Gng12 G protein subunit gamma 12 multiple interactions ISO Epinephrine promotes the reaction [GNG12 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr 4:97,634,925...97,763,478
Ensembl chr 4:97,657,671...97,760,102
JBrowse link
G Gng2 G protein subunit gamma 2 multiple interactions ISO Epinephrine promotes the reaction [GNG2 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr15:4,748,242...4,853,555
Ensembl chr15:4,850,122...4,853,555
JBrowse link
G Gng3 G protein subunit gamma 3 multiple interactions ISO Epinephrine promotes the reaction [GNG3 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr 1:225,033,921...225,035,687
Ensembl chr 1:225,033,921...225,035,687
JBrowse link
G Gng4 G protein subunit gamma 4 multiple interactions ISO Epinephrine promotes the reaction [GNG4 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr17:90,266,571...90,316,278
Ensembl chr17:90,266,794...90,315,492
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions ISO Epinephrine promotes the reaction [GRK2 protein results in increased phosphorylation of ADRB2 protein] CTD PMID:14722251 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 multiple interactions ISO Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein] CTD PMID:14722251 NCBI chr 1:282,265,371...282,467,842
Ensembl chr 1:282,265,370...282,462,605
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH protein CTD PMID:19464573 NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions
affects localization
EXP Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein]
Epinephrine affects the localization of HSF1 protein
CTD PMID:19135123 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSP90AB1 protein CTD PMID:19464573 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein CTD PMID:19464573 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Epinephrine results in increased expression of HSPA8 protein CTD PMID:19464573 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPA9 protein CTD PMID:19464573 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspb6 heat shock protein family B (small) member 6 decreases expression
multiple interactions
EXP Epinephrine results in decreased expression of HSPB6 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPB6 protein
CTD PMID:19464573 NCBI chr 1:89,008,117...89,010,256
Ensembl chr 1:89,008,117...89,010,256
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression
multiple interactions
EXP Epinephrine results in decreased expression of IDH2 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein
CTD PMID:19464573 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Epinephrine promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein] CTD PMID:10588509 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:10588509 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
EXP
ISO
Epinephrine results in decreased expression of IL6 mRNA
Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:10588509, PMID:12423672 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions
decreases expression
ISO [Epinephrine co-treated with INS protein] results in increased phosphorylation of AKT1 protein; Butoxamine inhibits the reaction [Epinephrine results in decreased expression of INS protein]; Pentolinium Tartrate inhibits the reaction [Epinephrine results in decreased secretion of INS protein]; Propranolol inhibits the reaction [Epinephrine results in decreased expression of INS protein] CTD PMID:1218171, PMID:6018752, PMID:6314140, PMID:32305330 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine] CTD PMID:16214444 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itgav integrin subunit alpha V increases expression ISO Epinephrine results in increased expression of ITGAV mRNA CTD PMID:12729923 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb1 integrin subunit beta 1 increases response to substance EXP ITGB1 results in increased susceptibility to Epinephrine CTD PMID:14984413 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions
increases expression
affects localization
increases activity
ISO
EXP
Theophylline inhibits the reaction [Epinephrine results in increased activity of LIPE protein]
Epinephrine results in increased expression of LIPE mRNA
Epinephrine affects the localization of LIPE protein
CTD PMID:7155675, PMID:10777495, PMID:11160373 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity
affects activity
ISO
EXP
ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; Epinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]
Epinephrine deficiency results in increased activity of MAPK1 protein
Epinephrine affects the activity of MAPK1 protein
CTD PMID:11093795, PMID:15292328, PMID:17680988, PMID:22496244 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
increases activity
affects activity
ISO
EXP
ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]
Epinephrine deficiency results in increased activity of MAPK3 protein
Epinephrine affects the activity of MAPK3 protein
CTD PMID:11093795, PMID:15292328, PMID:17680988, PMID:22496244 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Meis1 Meis homeobox 1 decreases expression ISO Epinephrine results in decreased expression of MEIS1 protein CTD PMID:31520687 NCBI chr14:103,182,178...103,321,809
Ensembl chr14:103,181,281...103,321,270
JBrowse link
G Myl2 myosin light chain 2 multiple interactions
affects expression
EXP [Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein
Epinephrine affects the expression of MYL2 protein
CTD PMID:19464573 NCBI chr12:39,951,863...39,959,065
Ensembl chr12:39,951,987...39,958,239
JBrowse link
G Nefh neurofilament heavy affects expression EXP Epinephrine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:19135123 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO
EXP
Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Epinephrine results in increased expression of NOS2 mRNA
CTD PMID:16925470, PMID:19439816 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ntf3 neurotrophin 3 increases expression EXP Epinephrine results in increased expression of NTF3 mRNA; Epinephrine results in increased expression of NTF3 protein CTD PMID:19854260 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G P2rx7 purinergic receptor P2X 7 decreases activity ISO Epinephrine results in decreased activity of P2RX7 protein CTD PMID:15459114 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G P2ry12 purinergic receptor P2Y12 multiple interactions ISO Epinephrine inhibits the reaction [P2RY12 gene mutant form results in decreased susceptibility to Adenosine Diphosphate] CTD PMID:11413167 NCBI chr 2:149,440,807...149,482,592
Ensembl chr 2:149,441,598...149,444,548
JBrowse link
G Phb prohibitin multiple interactions
increases expression
EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB protein
Epinephrine results in increased expression of PHB protein
CTD PMID:19464573 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP Epinephrine results in increased expression of PHGDH mRNA CTD PMID:12423672 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM protein CTD PMID:19464573 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Epinephrine results in increased expression of PPARGC1A mRNA CTD PMID:22496244 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha decreases expression
multiple interactions
EXP Epinephrine results in decreased expression of PPP2R1A protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PPP2R1A protein
CTD PMID:19464573 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions
decreases expression
EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PRDX6 protein
Epinephrine results in decreased expression of PRDX6 protein
CTD PMID:19464573 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
JBrowse link
G Prkce protein kinase C, epsilon affects response to substance ISO
EXP
PRKCE protein affects the susceptibility to Epinephrine CTD PMID:11454025 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Epinephrine results in decreased expression of PTGS2 mRNA; Epinephrine results in decreased expression of PTGS2 protein CTD PMID:31520687 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:19135123 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin multiple interactions
increases activity
ISO ICI 118551 inhibits the reaction [Epinephrine results in increased activity of REN protein] CTD PMID:6314140, PMID:8592096 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Sct secretin multiple interactions EXP Epinephrine inhibits the reaction [SCT protein results in increased abundance of Cyclic AMP] CTD PMID:6312992 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Epinephrine results in increased expression of SERPINE1 mRNA CTD PMID:15850565 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
increases uptake
EXP
ISO
[Corticosterone results in decreased activity of SLC22A3 protein] inhibits the reaction [Epinephrine results in increased abundance of Epinephrine metabolite]; [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased abundance of Epinephrine
SLC22A3 protein results in increased uptake of Epinephrine
CTD PMID:19053318, PMID:20858707 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc29a4 solute carrier family 29 member 4 increases uptake ISO SLC29A4 protein results in increased uptake of Epinephrine CTD PMID:20858707 NCBI chr12:13,914,114...13,924,511
Ensembl chr12:13,914,114...13,924,531
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
affects binding
increases expression
increases activity
ISO
EXP
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]; Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]; Vitamin E inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]
Epinephrine binds to SOD1 protein mutant form
[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 protein
Epinephrine results in increased expression of SOD1 protein
Epinephrine results in increased expression of SOD1 mRNA; Epinephrine results in increased expression of SOD1 protein
CTD PMID:11163531, PMID:19464573, PMID:23612299 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
increases activity
ISO
EXP
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]; Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]; Vitamin E inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of SOD2 protein
Epinephrine results in increased expression of SOD2 protein
Epinephrine results in increased expression of SOD2 mRNA; Epinephrine results in increased expression of SOD2 protein
CTD PMID:11163531, PMID:19464573 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta increases expression EXP Epinephrine results in increased expression of SUCLG2 protein CTD PMID:19464573 NCBI chr 4:127,552,100...127,824,970
Ensembl chr 4:127,552,101...127,824,970
JBrowse link
G Th tyrosine hydroxylase increases chemical synthesis
multiple interactions
ISO
EXP
TH protein results in increased chemical synthesis of Epinephrine
[Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine
CTD PMID:9822156, PMID:19067675 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions
decreases expression
ISO Propranolol inhibits the reaction [Epinephrine results in decreased expression of THY1] CTD PMID:7558147 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
decreases secretion
ISO
EXP
Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Epinephrine results in decreased expression of TNF mRNA
Epinephrine results in decreased secretion of TNF protein
CTD PMID:10588509, PMID:12423672 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression
multiple interactions
EXP Epinephrine results in increased expression of VDAC1 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of VDAC1 protein
CTD PMID:19464573 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Wnt4 Wnt family member 4 decreases expression ISO Epinephrine results in decreased expression of WNT4 mRNA; Epinephrine results in decreased expression of WNT4 protein CTD PMID:31520687 NCBI chr 5:155,649,238...155,668,065
Ensembl chr 5:155,649,217...155,672,579
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of AK2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DES protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DLAT protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ETFB protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of FABP3 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSP90AB1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPA9 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPB6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PPP2R1A protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PRDX6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of SOD2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of C1QBP protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of CYCS protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of VDAC1 protein; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein] CTD PMID:19135123, PMID:19464573 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
(S)-timolol (anhydrous) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Timolol binds to and results in decreased activity of ADRB1 protein; Timolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP] CTD PMID:11436944, PMID:15060759 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [Timolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; Timolol binds to and results in decreased activity of ADRB2 protein CTD PMID:11436944, PMID:17925438 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Aoc1 amine oxidase, copper containing 1 multiple interactions EXP Timolol inhibits the reaction [Epinephrine results in increased activity of AOC1 protein] CTD PMID:2860926 NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects response to substance ISO CYP2D6 gene SNP affects the susceptibility to Timolol CTD PMID:19284319, PMID:20925579 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]
CTD PMID:11914123, PMID:18977218 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]
CTD PMID:11914123, PMID:18977218 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Rgs3 regulator of G-protein signaling 3 multiple interactions ISO RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS3 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18977218 NCBI chr 5:78,429,017...78,567,281
Ensembl chr 5:78,428,669...78,567,288
JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions ISO RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS4 protein affects the reaction [[Timolol co-treated with Phenylephrine] results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18977218 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor increases expression EXP platelet-activating factor increases expression of Tnf protein in portal stenosis rat plasma RGD PMID:10452877 RGD:38508900 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
acebutolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions
increases activity
ISO [Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP; CGP 20712A inhibits the reaction [[Acebutolol co-treated with ADRB1] results in increased abundance of Cyclic AMP]; CGP 20712A inhibits the reaction [Acebutolol results in increased activity of ADRB1 protein] CTD PMID:12761341 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [Acebutolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Acebutolol results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein CTD PMID:17925438 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Acebutolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Ren renin decreases activity ISO
EXP
Acebutolol results in decreased activity of REN protein CTD PMID:6110712, PMID:6118215 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
albuterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO
EXP
Albuterol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Albuterol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein] CTD PMID:8096834, PMID:14730417 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 decreases response to substance
increases activity
multiple interactions
increases phosphorylation
decreases expression
ISO
EXP
ADRB2 gene polymorphism results in decreased susceptibility to Albuterol
Albuterol results in increased activity of ADRB2 protein
[Albuterol binds to and results in increased activity of ADRB2 protein] which results in decreased abundance of Potassium; [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Albuterol binds to and results in increased activity of ADRB2 protein; Albuterol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Atenolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]
Albuterol results in increased phosphorylation of ADRB2 protein
Albuterol results in decreased expression of ADRB2 protein
[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Hydroxyindoleacetic Acid; Albuterol binds to and results in increased activity of ADRB2 protein
CTD PMID:2463453, PMID:8102213, PMID:8937731, PMID:10516654, PMID:10952688, PMID:12920204, PMID:14722251, PMID:14730417, PMID:15467267, PMID:15687340, PMID:16980553, PMID:19120125, PMID:19363516 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO [Albuterol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Albuterol binds to and results in increased activity of ADRB3 protein; Albuterol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Albuterol results in increased expression of BAX CTD PMID:11802967 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Albuterol results in decreased expression of BCL2 CTD PMID:11802967 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol] CTD PMID:19462961 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein] CTD PMID:12818968 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO [Beclomethasone co-treated with Albuterol] results in decreased secretion of CCL5 protein CTD PMID:15679717 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]] CTD PMID:18076728 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO Albuterol results in increased expression of CDK2 protein CTD PMID:18362475 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO Albuterol results in increased expression of CDK4 protein CTD PMID:18362475 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Ckm creatine kinase, M-type increases secretion ISO Albuterol results in increased secretion of CKM protein CTD PMID:8970440 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [Beclomethasone co-treated with Albuterol] results in decreased secretion of CSF2 protein CTD PMID:15679717 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO Albuterol results in increased expression of CYP17A1 CTD PMID:17822730 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO [Cyproterone co-treated with Albuterol] results in decreased expression of CYP19A1 CTD PMID:17822730 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO [Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Albuterol promotes the reaction [Beclomethasone results in decreased activity of FGF2 protein] CTD PMID:18076728 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein] CTD PMID:18076728 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Albuterol results in increased activity of G6PD protein CTD PMID:1978808 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Il10 interleukin 10 decreases expression EXP Albuterol results in decreased expression of IL10 mRNA CTD PMID:16908771 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Albuterol promotes the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:11112151 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]] CTD PMID:18076728 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions ISO 1-Methyl-3-isobutylxanthine promotes the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]]; Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]; ICI 118551 inhibits the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]] CTD PMID:16238794 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO
EXP
Albuterol results in increased expression of IL6 protein
Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
[Albuterol co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Dexamethasone co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Theophylline co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Albuterol promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Albuterol promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD PMID:18362475, PMID:20388727, PMID:20519841 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 increases expression ISO Albuterol results in increased expression of INS; Albuterol results in increased expression of INS protein CTD PMID:8098220, PMID:9088585 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Ldlr low density lipoprotein receptor affects response to substance ISO LDLR gene SNP affects the susceptibility to Albuterol CTD PMID:15453913 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein
Albuterol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:16980553, PMID:20519841 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein
Albuterol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:16980553, PMID:20519841 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol; Ascorbic Acid inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; CAT protein inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Sodium Azide inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Sodium Cyanide inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol] CTD PMID:19462961 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Albuterol results in increased expression of NFKBIA protein CTD PMID:18362475 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:20519841 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO [Beclomethasone co-treated with Albuterol] affects the localization of NR3C1 protein CTD PMID:15679717 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Pde4a phosphodiesterase 4A multiple interactions ISO [Albuterol co-treated with Rolipram] results in increased expression of PDE4A mRNA CTD PMID:10763856 NCBI chr 8:22,189,533...22,234,036
Ensembl chr 8:22,189,600...22,233,748
JBrowse link
G Pde4b phosphodiesterase 4B multiple interactions ISO [Albuterol co-treated with Rolipram] results in increased expression of PDE4B mRNA CTD PMID:10763856 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Albuterol results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Albuterol results in increased expression of PPARGC1A mRNA CTD PMID:17446185 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ptafr platelet-activating factor receptor increases expression ISO Albuterol results in increased expression of PTAFR protein CTD PMID:18362475 NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Albuterol promotes the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:11112151 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression
multiple interactions
increases expression
ISO Albuterol results in decreased expression of RB1 protein
ICI 118551 inhibits the reaction [Albuterol results in decreased expression of RB1 protein]
Albuterol results in increased expression of RB1 protein
CTD PMID:16446544, PMID:18362475 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Ren renin increases expression ISO Albuterol results in increased expression of REN protein CTD PMID:2829953 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]] CTD PMID:18076728 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions
ISO
EXP
Albuterol results in decreased secretion of TNF protein
[Albuterol co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; [Dexamethasone co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Albuterol promotes the reaction [Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]
CTD PMID:8937731, PMID:10229875, PMID:20388727, PMID:20519841 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Albuterol results in increased expression of TP53 CTD PMID:11802967 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ucp1 uncoupling protein 1 increases expression ISO Albuterol results in increased expression of UCP1 protein CTD PMID:10465291 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions ISO [Albuterol co-treated with acipimox] results in decreased expression of UCP3 mRNA CTD PMID:12824081 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link
alprenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions
increases phosphorylation
increases activity
ISO [Alprenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Alprenolol binds to and results in decreased activity of ADRB1 protein; Alprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Alprenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Alprenolol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; Alprenolol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; CGP 20712A affects the reaction [Alprenolol results in increased activity of ADRB1 protein]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
[Alprenolol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein; Alprenolol results in increased phosphorylation of ADRB1 protein
CTD PMID:12761341, PMID:14730417, PMID:15060759, PMID:18787115 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [Alprenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Alprenolol co-treated with ADRB2 protein] results in increased expression of GNAS protein; Alprenolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]
Alprenolol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]; Alprenolol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein]
CTD PMID:10455254, PMID:12198331, PMID:14730417, PMID:17925438 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO [Alprenolol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Alprenolol binds to and results in increased activity of ADRB3 protein; Alprenolol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA; [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA; [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA; [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR214 mRNA; Alprenolol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]] CTD PMID:18787115, PMID:24334028 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO Alprenolol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]] CTD PMID:18787115 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
[Alprenolol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein
CTD PMID:18787115 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Gnas GNAS complex locus multiple interactions ISO [Alprenolol co-treated with ADRB2 protein] results in increased expression of GNAS protein CTD PMID:10455254 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions ISO Alprenolol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein] CTD PMID:12198331 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Alprenolol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]] CTD PMID:18787115 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO [Alprenolol co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] CTD PMID:8392199 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]
Erlotinib Hydrochloride inhibits the reaction [Alprenolol results in increased phosphorylation of MAPK1 protein]
CTD PMID:17925438, PMID:18787115 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [Alprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; ARRB1 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Alprenolol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]
Erlotinib Hydrochloride inhibits the reaction [Alprenolol results in increased phosphorylation of MAPK3 protein]
CTD PMID:17925438, PMID:18787115 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mir125a microRNA 125a multiple interactions
increases expression
ISO [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA
Alprenolol results in increased expression of MIR125A mRNA
CTD PMID:24334028 NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911
JBrowse link
G Mir125b1 microRNA 125b-1 multiple interactions
increases expression
ISO [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA
Alprenolol results in increased expression of MIR125B-1 mRNA
CTD PMID:24334028 NCBI chr 8:45,798,260...45,798,346
Ensembl chr 8:45,798,260...45,798,346
JBrowse link
G Mir150 microRNA 150 multiple interactions
increases expression
ISO [Alprenolol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA
Alprenolol results in increased expression of MIR150 mRNA
CTD PMID:24334028 NCBI chr 1:101,115,974...101,116,058
Ensembl chr 1:101,115,974...101,116,058
JBrowse link
G Nppa natriuretic peptide A increases expression ISO Alprenolol results in increased expression of NPPA mRNA CTD PMID:12721106 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO Alprenolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein] CTD PMID:10353628 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Ren renin multiple interactions
decreases expression
ISO Alprenolol inhibits the reaction [Hydralazine results in increased expression of REN protein]
Alprenolol results in decreased expression of REN protein
CTD PMID:923630 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Alprenolol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
arbutamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions EXP arbutamine binds to and results in increased activity of ADRB1 protein CTD PMID:8723169 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
atenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Atenolol inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Atenolol results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Adra2a adrenoceptor alpha 2A affects response to substance ISO ADRA2A gene SNP affects the susceptibility to Atenolol CTD PMID:15614026 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adrb1 adrenoceptor beta 1 decreases activity
multiple interactions
affects binding
affects response to substance
decreases expression
ISO
EXP
Atenolol results in decreased activity of ADRB1 protein
Atenolol binds to and results in decreased activity of ADRB1 protein; Atenolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]
Atenolol binds to ADRB1 protein
[Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; [Atenolol binds to and results in decreased activity of ADRB1 protein] which results in decreased susceptibility to Nicotine; [Atenolol co-treated with ADRB1] results in increased abundance of Cyclic AMP; Atenolol binds to and results in decreased activity of ADRB1 protein; Atenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]; Atenolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Atenolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]
ADRB1 protein polymorphism affects the susceptibility to Atenolol
Atenolol results in decreased expression of ADRB1 mRNA
CTD PMID:1389726, PMID:2462161, PMID:2897299, PMID:8102213, PMID:8386603, PMID:9593075, PMID:10372227, PMID:10894789, PMID:11425575, PMID:11483288, PMID:12022239, PMID:12761341, PMID:14730417, PMID:15060759, PMID:17003101, PMID:17369603, PMID:17628611, PMID:22192668 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression
affects binding
multiple interactions
ISO
EXP
Atenolol results in increased expression of ADRB2 protein
Atenolol binds to ADRB2 protein
Atenolol binds to and results in decreased activity of ADRB2 protein; Atenolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Atenolol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]
[Atenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Atenolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Atenolol binds to and results in decreased activity of ADRB2 protein; Atenolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Atenolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Atenolol inhibits the reaction [Terbutaline binds to and results in increased activity of ADRB2 protein]
CTD PMID:2462161, PMID:6093157, PMID:9593075, PMID:11425575, PMID:11483288, PMID:12920204, PMID:14730417, PMID:17925438 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO Atenolol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Agt angiotensinogen affects response to substance
decreases expression
ISO AGT gene SNP affects the susceptibility to Atenolol
Atenolol results in decreased expression of AGT protein
CTD PMID:14639093, PMID:14700505 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Amy2a3 amylase 2a3 multiple interactions EXP Atenolol inhibits the reaction [Apomorphine results in increased secretion of and results in increased activity of AMY1A protein]; Atenolol inhibits the reaction [Cisplatin results in increased secretion of and results in increased activity of AMY1A protein]; Atenolol inhibits the reaction [Isoproterenol results in increased secretion of and results in increased activity of AMY1A protein]; Atenolol inhibits the reaction [Lithium Chloride results in increased secretion of and results in increased activity of AMY1A protein] CTD PMID:21173550 NCBI chr 2:216,373,674...216,382,260
Ensembl chr 2:216,339,154...216,382,260
JBrowse link
G Apoa1 apolipoprotein A1 decreases expression ISO Atenolol results in decreased expression of APOA1 protein CTD PMID:2193493 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa2 apolipoprotein A2 decreases expression ISO Atenolol results in decreased expression of APOA2 protein CTD PMID:2193493 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Apob apolipoprotein B increases expression ISO Atenolol results in increased expression of APOB; Atenolol results in increased expression of APOB protein CTD PMID:1928808, PMID:2193493 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein] CTD PMID:16671086 NCBI chr 7:141,882,261...141,924,790
Ensembl chr 7:141,882,251...141,924,788
JBrowse link
G B2m beta-2 microglobulin decreases expression ISO Atenolol results in decreased expression of B2M protein CTD PMID:2656332 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Bdkrb2 bradykinin receptor B2 affects response to substance ISO BDKRB2 exon polymorphism affects the susceptibility to Atenolol CTD PMID:12640257 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C increases response to substance ISO CACNA1C gene polymorphism results in increased susceptibility to Atenolol CTD PMID:20031608 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Atenolol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein] CTD PMID:10728402 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions EXP Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Atenolol promotes the reaction [Quercetin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]]; Atenolol promotes the reaction [Thyroxine results in decreased expression of CAT protein]; Quercetin promotes the reaction [Atenolol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]] CTD PMID:2575990, PMID:22391854 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO Atenolol inhibits the reaction [Isoproterenol results in increased expression of CDK1 mRNA] CTD PMID:9593584 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein] CTD PMID:16671086 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Edn1 endothelin 1 affects response to substance ISO EDN1 gene polymorphism affects the susceptibility to Atenolol CTD PMID:15188945 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of EGFR protein] CTD PMID:16671086 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Atenolol inhibits the reaction [Epinephrine results in increased expression of FAS protein] CTD PMID:10728402 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions ISO Atenolol inhibits the reaction [Epinephrine results in increased expression of FASLG protein] CTD PMID:10728402 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B multiple interactions ISO Atenolol promotes the reaction [FKBP1B protein binds to RYR2 protein] CTD PMID:12743001 NCBI chr 6:29,975,863...29,987,252
Ensembl chr 6:29,977,797...29,987,451
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 decreases expression ISO Atenolol results in decreased expression of FKBP5 mRNA CTD PMID:19915711 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Atenolol inhibits the reaction [Dopamine results in increased activity of G6PD protein]; Atenolol inhibits the reaction [Isoproterenol results in increased activity of G6PD protein] CTD PMID:1978808 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP Atenolol results in increased expression of GJA1 protein CTD PMID:16448880 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gja4 gap junction protein, alpha 4 increases expression EXP Atenolol results in increased expression of GJA4 protein CTD PMID:16448880 NCBI chr 5:145,374,688...145,377,221
Ensembl chr 5:145,374,690...145,377,221
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 decreases expression ISO Atenolol results in decreased expression of GRK2 mRNA; Atenolol results in decreased expression of GRK2 protein CTD PMID:9788834 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Atenolol inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:12795776 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 affects response to substance ISO KCNJ2 gene affects the susceptibility to Atenolol CTD PMID:15028050 NCBI chr10:99,429,337...99,442,520
Ensembl chr10:99,437,436...99,439,114
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 affects response to substance ISO KCNQ1 gene affects the susceptibility to Atenolol CTD PMID:15028050 NCBI chr 1:216,293,087...216,630,339
Ensembl chr 1:216,293,087...216,630,339
JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO LIPC gene SNP affects the susceptibility to and affects the metabolism of Atenolol CTD PMID:23536766 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK1 protein] CTD PMID:16671086, PMID:17003101, PMID:17925438 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Atenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Atenolol inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK3 protein] CTD PMID:16671086, PMID:17003101, PMID:17925438 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Atenolol inhibits the reaction [Carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:19439816 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Atenolol results in decreased expression of NPPA protein CTD PMID:12866806 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression
increases expression
EXP
ISO
[Atenolol co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA
Atenolol results in decreased expression of NPPB mRNA
Atenolol results in increased expression of NPPB protein
CTD PMID:15969258, PMID:18192850 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Pla2g4c phospholipase A2 group IVC multiple interactions ISO PLA2G4C gene SNP affects the susceptibility to and affects the metabolism of Atenolol CTD PMID:23536766 NCBI chr 1:75,440,035...75,481,995
Ensembl chr 1:75,428,027...75,620,911
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Atenolol binds to and results in decreased activity of ADRB1 protein] inhibits the reaction [Nicotine results in increased expression of PTGS2 protein] CTD PMID:17003101 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 multiple interactions EXP Atenolol inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein] CTD PMID:17623046 NCBI chr 1:103,197,918...103,258,309
Ensembl chr 1:103,197,915...103,256,823
JBrowse link
G Ren renin multiple interactions
decreases expression
decreases activity
ISO
EXP
[aliskiren co-treated with Atenolol] results in decreased activity of REN protein; [Dexamethasone co-treated with Nifedipine co-treated with Atenolol co-treated with Antihypertensive Agents] results in increased secretion of REN protein
Atenolol results in decreased expression of REN protein
Atenolol inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of REN protein]; Atenolol inhibits the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]
Atenolol results in decreased activity of REN protein
CTD PMID:3142437, PMID:3333524, PMID:9300315, PMID:14639093, PMID:18957387 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Ryr2 ryanodine receptor 2 increases activity
multiple interactions
ISO Atenolol results in increased activity of RYR2 protein
Atenolol promotes the reaction [FKBP1B protein binds to RYR2 protein]
CTD PMID:12743001 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G Slc19a1 solute carrier family 19 member 1 decreases expression ISO Atenolol results in decreased expression of SLC19A1 mRNA CTD PMID:19616087 NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Atenolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc6a8 solute carrier family 6 member 8 decreases expression ISO Atenolol results in decreased expression of SLC6A8 mRNA CTD PMID:19915711 NCBI chr  X:157,129,987...157,139,321
Ensembl chr  X:157,129,987...157,139,291
JBrowse link
G Slco4c1 solute carrier organic anion transporter family, member 4C1 increases expression ISO Atenolol results in increased expression of SLCO4C1 mRNA CTD PMID:19915711 NCBI chr 9:104,301,935...104,350,262
Ensembl chr 9:104,299,277...104,350,308
JBrowse link
G Snrpn small nuclear ribonucleoprotein polypeptide N increases expression ISO Atenolol results in increased expression of SNRPN mRNA CTD PMID:19915711 NCBI chr 1:195,074,328...195,096,460
Ensembl chr 1:195,074,330...195,096,460
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO
EXP
Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]
Atenolol promotes the reaction [Thyroxine results in decreased expression of SOD1 protein]
CTD PMID:2575990, PMID:11163531 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO
EXP
Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]
Atenolol inhibits the reaction [Thyroxine results in increased expression of SOD2 protein]
CTD PMID:2575990, PMID:11163531 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 decreases response to substance ISO TRPA1 gene mutant form results in decreased susceptibility to Atenolol CTD PMID:29627347 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Atenolol results in increased expression of TXN mRNA CTD PMID:19915711 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
bambuterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO bambuterol results in decreased activity of ACHE protein CTD PMID:18582854 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO bambuterol results in decreased activity of BCHE protein CTD PMID:15652380, PMID:18582854, PMID:18977317 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
betaxolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions
affects binding
EXP
ISO
Betaxolol affects the reaction [Cocaine affects the expression of ADRB1 protein]; Betaxolol inhibits the reaction [Cocaine affects the expression of ADRB1 protein]
Betaxolol binds to ADRB1 protein
Betaxolol binds to and results in decreased activity of ADRB1 protein
CTD PMID:10372227, PMID:11436944, PMID:17513029, PMID:18596687 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [Betaxolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; Betaxolol binds to and results in decreased activity of ADRB2 protein CTD PMID:11436944, PMID:17925438 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Betaxolol affects the reaction [Cocaine affects the phosphorylation of CREB1 protein] CTD PMID:18596687 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crh corticotropin releasing hormone multiple interactions EXP Betaxolol affects the reaction [Cocaine affects the expression of CRH mRNA] CTD PMID:18596687 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Nppa natriuretic peptide A decreases expression EXP Betaxolol results in decreased expression of NPPA mRNA; Betaxolol results in decreased expression of NPPA protein CTD PMID:12693380 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B decreases expression EXP Betaxolol results in decreased expression of NPPB mRNA CTD PMID:12693380 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
bevantolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 decreases expression EXP bevantolol results in decreased expression of ADRB1 mRNA CTD PMID:17628611 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
bisoprolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
ISO ABCB1 protein results in increased transport of Bisoprolol
Bisoprolol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of Bisoprolol]
CTD PMID:16671962 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Adrb1 adrenoceptor beta 1 decreases activity
increases expression
multiple interactions
affects binding
ISO
EXP
Bisoprolol results in decreased activity of ADRB1 protein
Bisoprolol results in increased expression of ADRB1 mRNA
[Bisoprolol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; Bisoprolol binds to and results in decreased activity of ADRB1 protein; Bisoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Bisoprolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]
Bisoprolol binds to ADRB1 protein
CTD PMID:1389726, PMID:2897299, PMID:10372227, PMID:11562432, PMID:12535855, PMID:14730417, PMID:15060759, PMID:17200720, PMID:20668454 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases expression
ISO
EXP
[Bisoprolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; [Bisoprolol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; Bisoprolol binds to and results in decreased activity of ADRB2 protein; Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB2 protein]
Bisoprolol results in increased expression of ADRB2 mRNA
CTD PMID:14730417, PMID:17925438, PMID:20668454 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO Bisoprolol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Bisoprolol results in decreased expression of CCL2 protein CTD PMID:19840533 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Gnas GNAS complex locus increases expression EXP Bisoprolol results in increased expression of GNAS mRNA CTD PMID:20668454 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Il10 interleukin 10 increases expression ISO Bisoprolol results in increased expression of IL10 protein CTD PMID:19840533 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Bisoprolol results in decreased expression of IL1B protein CTD PMID:19840533 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression ISO Bisoprolol results in decreased expression of IL6 protein CTD PMID:19840533 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Bisoprolol inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:12795776 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Prkca protein kinase C, alpha decreases expression EXP Bisoprolol results in decreased expression of PRKCA protein CTD PMID:20668454 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcd protein kinase C, delta decreases expression EXP Bisoprolol results in decreased expression of PRKCD protein CTD PMID:20668454 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Bisoprolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Bisoprolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin] CTD PMID:19740083 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Bisoprolol results in decreased expression of TNF protein CTD PMID:19840533 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
bopindolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO bopindolol results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO bopindolol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
carteolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Carteolol binds to and results in decreased activity of ADRB1 protein CTD PMID:11436944 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Carteolol binds to and results in decreased activity of ADRB2 protein CTD PMID:11436944 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
carvedilol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
decreases activity
ISO
EXP
ABCB1 protein results in increased transport of carvedilol
[Cyclosporine results in decreased activity of ABCB1 protein] which results in increased uptake of carvedilol
[carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]] which results in decreased susceptibility to Daunorubicin; [carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Doxorubicin]] which results in decreased susceptibility to Doxorubicin; [carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Paclitaxel]] which results in decreased susceptibility to Paclitaxel; [carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]] which results in decreased susceptibility to Vinblastine; [carvedilol results in decreased activity of ABCB1 protein] which results in increased susceptibility to Doxorubicin; [carvedilol results in decreased activity of ABCB1 protein] which results in increased uptake of fluorexon; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Daunorubicin]; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Doxorubicin]; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Paclitaxel]; carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Vinblastine]; valspodar inhibits the reaction [ABCB1 protein results in increased transport of carvedilol]
CTD PMID:10571255, PMID:11895100, PMID:12708479, PMID:16671962, PMID:17609666 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP
ISO
carvedilol inhibits the reaction [Colchicine results in decreased activity of ACE protein]
carvedilol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ACE mRNA]
CTD PMID:15071347, PMID:18992766 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Carvedilol inhibits the reaction [Ethanol results in increased expression of ACTA2 mRNA]; Carvedilol inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]
carvedilol results in decreased expression of ACTA2 protein
CTD PMID:20403466, PMID:22413959, PMID:30254303 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actn4 actinin alpha 4 decreases expression EXP carvedilol results in decreased expression of ACTN4 protein CTD PMID:20403466 NCBI chr 1:87,078,012...87,147,347
Ensembl chr 1:87,078,020...87,147,333
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO carvedilol results in decreased expression of ADIPOQ protein CTD PMID:19367012 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions
decreases expression
ISO
EXP
Carvedilol binds to and results in decreased activity of ADRA1A protein; Carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]
carvedilol results in decreased expression of ADRA1A mRNA
CTD PMID:15306222, PMID:20668454 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions ISO carvedilol binds to and results in decreased activity of ADRA1B protein; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium] CTD PMID:15306222 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions ISO carvedilol binds to and results in decreased activity of ADRA1D protein; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium] CTD PMID:15306222 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions
affects binding
increases expression
increases phosphorylation
increases activity
affects response to substance
ISO
EXP
[ADRB1 gene co-treated with ADRB2 gene] affects the susceptibility to Carvedilol; [Carvedilol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; [Carvedilol co-treated with ADRB1] results in increased abundance of Cyclic AMP; ADRB1 protein polymorphism affects the reaction [[Carvedilol binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP]; ADRB1 protein polymorphism affects the susceptibility to [Carvedilol co-treated with Angiotensin Receptor Antagonists]; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Carvedilol binds to and results in decreased activity of ADRB1 protein; Carvedilol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Carvedilol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Carvedilol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; Carvedilol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; CGP 20712A inhibits the reaction [[Carvedilol co-treated with ADRB1] results in increased abundance of Cyclic AMP]; CGP 20712A inhibits the reaction [Carvedilol results in increased activity of ADRB1 protein]; Guanine Nucleotides affects the reaction [Carvedilol binds to ADRB1 protein]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
carvedilol binds to ADRB1 protein
carvedilol results in increased expression of ADRB1 mRNA
carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; carvedilol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]
[carvedilol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein; carvedilol results in increased phosphorylation of ADRB1 protein
carvedilol results in increased activity of ADRB1 protein
ADRB1 gene polymorphism affects the susceptibility to carvedilol; ADRB1 protein polymorphism affects the susceptibility to carvedilol
CTD PMID:1378154, PMID:2462161, PMID:7908256, PMID:10372227, PMID:12535855, PMID:12761341, PMID:14502278, PMID:14730417, PMID:15060759, PMID:15306222, PMID:16475467, PMID:17200720, PMID:18075464, PMID:18787115, PMID:20643254, PMID:20668454, PMID:21216836, PMID:21395649, PMID:21516734, PMID:21599570, PMID:22192668 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases phosphorylation
affects binding
increases expression
increases uptake
affects response to substance
ISO
EXP
[ADRB1 gene co-treated with ADRB2 gene] affects the susceptibility to carvedilol; [carvedilol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP; [carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [carvedilol binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; [carvedilol co-treated with ADRB2 protein] results in increased expression of GNAS protein; [carvedilol co-treated with ADRB2 protein] results in increased expression of GRK2 protein; carvedilol binds to and results in decreased activity of ADRB2 protein; carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; carvedilol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; carvedilol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]; Guanine Nucleotides affects the reaction [carvedilol binds to ADRB2 protein]; ICI 118551 inhibits the reaction [[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein]; ICI 118551 inhibits the reaction [[carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein]; ICI 118551 inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]; Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]; Propranolol inhibits the reaction [carvedilol results in increased phosphorylation of ADRB2 protein]
carvedilol results in increased expression of ADRB2 mRNA
carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; carvedilol inhibits the reaction [Dihydroalprenolol binds to ADRB2 protein]
carvedilol inhibits the reaction [ADRB2 results in decreased susceptibility to Histamine]; carvedilol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein]
carvedilol results in increased uptake of ADRB2 protein
ADRB2 gene SNP affects the susceptibility to carvedilol; ADRB2 protein polymorphism affects the susceptibility to carvedilol
CTD PMID:1378154, PMID:2462161, PMID:10372227, PMID:10455254, PMID:12198331, PMID:12535855, PMID:12835612, PMID:14730417, PMID:15306222, PMID:16225854, PMID:17925438, PMID:19034036, PMID:19175363, PMID:19422106, PMID:20352314, PMID:20668454, PMID:21216836, PMID:21395649, PMID:21599570 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
decreases expression
affects response to substance
ISO
EXP
carvedilol inhibits the reaction [cyanopindolol binds to ADRB3 protein]
carvedilol results in decreased expression of ADRB3 mRNA
ADRB3 affects the susceptibility to carvedilol
CTD PMID:11159692, PMID:14730417, PMID:17440824 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Agt angiotensinogen multiple interactions
decreases response to substance
decreases expression
EXP
ISO
[Losartan co-treated with Carvedilol] results in decreased susceptibility to AGT protein modified form; Carvedilol inhibits the reaction [AGT protein affects the localization of RAC1 protein]; Carvedilol inhibits the reaction [AGT protein results in increased abundance of Glycerol]; Carvedilol inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]; Carvedilol inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; Carvedilol inhibits the reaction [Losartan results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [Carvedilol results in decreased susceptibility to AGT protein modified form]
carvedilol results in decreased susceptibility to AGT protein modified form
carvedilol inhibits the reaction [AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]]; carvedilol inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]
carvedilol results in decreased expression of AGT protein
CTD PMID:12004934, PMID:12538430, PMID:15741261, PMID:16794485, PMID:16940222, PMID:19183357, PMID:21047287, PMID:21166975 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP
ISO
carvedilol results in increased phosphorylation of AKT1 protein CTD PMID:27288437 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein decreases expression ISO carvedilol results in decreased expression of APP protein modified form CTD PMID:20579773 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA; [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA; [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA; [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA; [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR214 mRNA; ARRB1 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; carvedilol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; carvedilol promotes the reaction [ARRB1 protein binds to DROSHA protein]; carvedilol promotes the reaction [ARRB1 protein binds to HNRNPA1 protein]; Colforsin inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; GRK5 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; GRK6 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; Metoprolol inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]
ARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125A mRNA]; ARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]; ARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR150 mRNA]; ARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR214 mRNA]; carvedilol promotes the reaction [ARRB1 protein binds to DROSHA protein]; carvedilol promotes the reaction [ARRB1 protein binds to HNRNPA1 protein]
CTD PMID:18787115, PMID:24334028 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions
affects localization
ISO
EXP
ARRB2 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [carvedilol results in increased phosphorylation of MAPK1 protein]; ARRB2 protein promotes the reaction [carvedilol results in increased phosphorylation of MAPK3 protein]; carvedilol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]; ICI 118551 inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]; Propranolol inhibits the reaction [carvedilol promotes the reaction [ADRB2 protein binds to ARRB2 protein]]
ARRB2 promotes the reaction [carvedilol results in increased uptake of Calcium]
carvedilol affects the localization of ARRB2 protein
CTD PMID:17925438, PMID:18787115, PMID:21078978 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions
increases expression
EXP carvedilol inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 mRNA]; carvedilol inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 protein]
carvedilol results in increased expression of ATP2A2 mRNA
CTD PMID:15670758, PMID:16026515, PMID:16162791 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Avp arginine vasopressin decreases expression
multiple interactions
ISO
EXP
carvedilol results in decreased expression of AVP protein
carvedilol inhibits the reaction [AVP protein results in increased import of and results in increased abundance of Calcium]
CTD PMID:12523682, PMID:14711191 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP [[Oxygen deficiency co-treated with Glucose deficiency] results in increased susceptibility to Carvedilol] which results in decreased expression of BAK1 mRNA CTD PMID:29122578 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
EXP
ISO
carvedilol inhibits the reaction [Doxorubicin results in increased expression of BAX mRNA]; carvedilol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; carvedilol inhibits the reaction [Potassium Dichromate results in increased expression of BAX protein]
carvedilol inhibits the reaction [Cisplatin results in increased expression of BAX protein]
carvedilol results in increased expression of BAX protein
carvedilol results in decreased expression of BAX
CTD PMID:12973927, PMID:15380674, PMID:20079142, PMID:24012798, PMID:25245570, PMID:26036690 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
affects expression
EXP carvedilol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]; carvedilol inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; carvedilol inhibits the reaction [Potassium Dichromate results in decreased expression of BCL2 protein]
carvedilol results in increased expression of BCL2 mRNA
carvedilol affects the expression of BCL2 protein
CTD PMID:15380674, PMID:16780994, PMID:16909474, PMID:22000973, PMID:25245570, PMID:26036690 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP carvedilol results in increased expression of BCL2L1 protein CTD PMID:20079142 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Becn1 beclin 1 increases expression EXP carvedilol results in increased expression of BECN1 protein CTD PMID:20079142 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP capsazepine inhibits the reaction [carvedilol results in increased secretion of [CALCA protein co-treated with CALCB protein]]; carvedilol results in increased secretion of [CALCA protein co-treated with CALCB protein] CTD PMID:14764656 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Calcb calcitonin-related polypeptide, beta multiple interactions EXP capsazepine inhibits the reaction [carvedilol results in increased secretion of [CALCA protein co-treated with CALCB protein]]; carvedilol results in increased secretion of [CALCA protein co-treated with CALCB protein] CTD PMID:14764656 NCBI chr 1:184,271,116...184,276,480
Ensembl chr 1:184,271,590...184,276,475
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Carvedilol inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Carvedilol inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Carvedilol inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Carvedilol inhibits the reaction [Potassium Dichromate results in increased cleavage of CASP3 protein]
carvedilol inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]
carvedilol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]
CTD PMID:10728402, PMID:15380674, PMID:21044617, PMID:24012798, PMID:25245570, PMID:26036690 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
increases activity
EXP Carvedilol inhibits the reaction [Arginine results in decreased activity of CAT protein]; Carvedilol inhibits the reaction [Chlorpromazine results in decreased expression of CAT protein]; Carvedilol inhibits the reaction [Haloperidol results in decreased expression of CAT protein]; Carvedilol inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]
carvedilol results in increased activity of CAT protein
CTD PMID:12010767, PMID:16909474, PMID:25245570, PMID:32569593 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in decreased expression of CDH1 protein] CTD PMID:30254303 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cfl1 cofilin 1 decreases expression EXP carvedilol results in decreased expression of CFL1 protein CTD PMID:20403466 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
EXP carvedilol inhibits the reaction [[Sodium, Dietary co-treated with Dietary Fats] results in increased expression of COL1A1 mRNA]; carvedilol inhibits the reaction [Ethanol results in increased expression of COL1A1 mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]
carvedilol decreases expression of collagen I mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats
Carvedilol results in decreased expression of COL1A1 mRNA; Carvedilol results in decreased expression of COL1A1 protein
CTD PMID:10722803, PMID:11181017, PMID:11682445, PMID:19575289, PMID:21216836, PMID:22413959, PMID:11682445 RGD:30296650 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions
decreases expression
EXP carvedilol inhibits the reaction [[Sodium, Dietary co-treated with Dietary Fats] results in increased expression of COL3A1 mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]
carvedilol decreases expression of collagen III mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats
carvedilol results in decreased expression of COL3A1 protein
CTD PMID:10722803, PMID:11181017, PMID:11682445, PMID:11682445 RGD:30296650 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Crp C-reactive protein decreases expression
multiple interactions
ISO
EXP
carvedilol results in decreased expression of CRP protein
Carvedilol inhibits the reaction [Arginine results in increased expression of CRP protein]
CTD PMID:15047035, PMID:32569593 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO carvedilol inhibits the reaction [CSF2 results in increased expression of IL10 mRNA]; carvedilol inhibits the reaction [CSF2 results in increased expression of IL10 protein] CTD PMID:12722941 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cycs cytochrome c, somatic increases expression EXP carvedilol results in increased expression of CYCS protein CTD PMID:18971572 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing EXP CYP2C11 protein results in increased metabolism of carvedilol CTD PMID:29415952 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 increases metabolic processing EXP CYP2D2 protein results in increased metabolism of carvedilol CTD PMID:29415952 NCBI chr 7:123,651,827...123,655,896
Ensembl chr 7:123,651,827...123,655,896
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects glucuronidation
affects metabolic processing
affects response to substance
ISO CYP2D6 gene polymorphism affects the glucuronidation of carvedilol
CYP2D6 gene polymorphism affects the metabolism of carvedilol; CYP2D6 protein polymorphism affects the metabolism of carvedilol
CYP2D6 gene polymorphism affects the susceptibility to carvedilol
CTD PMID:15001973, PMID:16595916, PMID:16849011, PMID:17329852, PMID:20643254, PMID:20686235, PMID:21599570 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing EXP CYP3A2 protein results in increased metabolism of carvedilol CTD PMID:29415952 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases metabolic processing EXP CYP3A23-3A1 protein results in increased metabolism of Carvedilol CTD PMID:29415952 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 decreases expression ISO carvedilol results in decreased expression of DDIT4 mRNA CTD PMID:27288437 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Drosha drosha ribonuclease III multiple interactions ISO carvedilol promotes the reaction [ARRB1 protein binds to DROSHA protein] CTD PMID:24334028 NCBI chr 2:62,887,267...63,000,307
Ensembl chr 2:62,887,267...62,999,572
JBrowse link
G Edn1 endothelin 1 decreases secretion
decreases expression
multiple interactions
ISO
EXP
carvedilol results in decreased secretion of EDN1 protein
carvedilol results in decreased expression of EDN1 mRNA
carvedilol inhibits the reaction [EDN1 protein results in increased import of and results in increased abundance of Calcium]
carvedilol results in decreased expression of EDN1 mRNA; carvedilol results in decreased expression of EDN1 protein
carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]; carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 protein]
CTD PMID:9500873, PMID:11078433, PMID:14711191, PMID:16428915, PMID:18971572 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation
ISO AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
[carvedilol results in increased phosphorylation of ADRB1 protein] which results in increased phosphorylation of EGFR protein
CTD PMID:18787115 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP [irbesartan co-treated with carvedilol] results in decreased expression of F3 mRNA; [irbesartan co-treated with carvedilol] results in decreased expression of F3 protein CTD PMID:21229253 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO carvedilol inhibits the reaction [Epinephrine results in increased expression of FAS protein] CTD PMID:10728402 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions ISO carvedilol inhibits the reaction [Epinephrine results in increased expression of FASLG protein] CTD PMID:10728402 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP carvedilol inhibits the reaction [Ethanol results in increased expression of FASN mRNA] CTD PMID:22413959 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B multiple interactions ISO carvedilol promotes the reaction [FKBP1B protein binds to RYR2 protein] CTD PMID:12743001 NCBI chr 6:29,975,863...29,987,252
Ensembl chr 6:29,977,797...29,987,451
JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression
EXP carvedilol inhibits the reaction [[Sodium, Dietary co-treated with Dietary Fats] results in increased expression of FN1 mRNA]; carvedilol inhibits the reaction [Streptozocin results in increased expression of FN1 protein]
carvedilol decreases expression of fibronectin mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats
carvedilol results in decreased expression of FN1 protein
CTD PMID:11181017, PMID:11682445, PMID:12140129, PMID:11682445 RGD:30296650 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gap43 growth associated protein 43 decreases expression EXP carvedilol results in decreased expression of GAP43 mRNA; carvedilol results in decreased expression of GAP43 protein CTD PMID:20359859 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gata4 GATA binding protein 4 decreases phosphorylation EXP carvedilol results in decreased phosphorylation of GATA4 protein CTD PMID:21472269 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression
affects localization
decreases phosphorylation
increases phosphorylation
decreases degradation
ISO
EXP
carvedilol results in increased expression of GJA1 mRNA; carvedilol results in increased expression of GJA1 protein
carvedilol affects the localization of GJA1 protein
carvedilol results in decreased phosphorylation of GJA1 protein
carvedilol results in increased phosphorylation of GJA1 protein
carvedilol results in decreased degradation of GJA1 protein
CTD PMID:16448880, PMID:16563290, PMID:17445419, PMID:18971572, PMID:19478468 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gja4 gap junction protein, alpha 4 increases expression EXP carvedilol results in increased expression of GJA4 protein CTD PMID:16448880 NCBI chr 5:145,374,688...145,377,221
Ensembl chr 5:145,374,690...145,377,221
JBrowse link
G Gnas GNAS complex locus multiple interactions
increases expression
ISO
EXP
[carvedilol co-treated with ADRB2 protein] results in increased expression of GNAS protein
carvedilol results in increased expression of GNAS mRNA
CTD PMID:10455254, PMID:20668454 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gpnmb glycoprotein nmb decreases expression EXP carvedilol results in decreased expression of GPNMB protein CTD PMID:20403466 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:30254303 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions
decreases expression
increases expression
ISO [carvedilol co-treated with ADRB2 protein] results in increased expression of GRK2 protein
carvedilol results in decreased expression of GRK2 protein
carvedilol results in increased expression of GRK2 protein
carvedilol inhibits the reaction [ADRB2 results in increased expression of GRK2 protein]
CTD PMID:9788834, PMID:10455254, PMID:12198331 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 multiple interactions ISO GRK5 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]
GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125A mRNA]; GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]; GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR150 mRNA]; GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR214 mRNA]
CTD PMID:24334028 NCBI chr 1:282,265,371...282,467,842
Ensembl chr 1:282,265,370...282,462,605
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 multiple interactions ISO GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR125A mRNA]; GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR125B-1 mRNA]; GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR150 mRNA]; GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR214 mRNA]
GRK6 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]
CTD PMID:24334028 NCBI chr17:9,705,917...9,721,921
Ensembl chr17:9,703,453...9,721,574
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO HBEGF protein inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [carvedilol promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]] CTD PMID:18787115 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO carvedilol results in increased expression of HMOX1 mRNA CTD PMID:11688356, PMID:12227681 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 multiple interactions ISO carvedilol promotes the reaction [ARRB1 protein binds to HNRNPA1 protein] CTD PMID:24334028 NCBI chr 7:144,865,302...144,871,592
Ensembl chr 7:144,865,608...144,871,585
JBrowse link
G Hpca hippocalcin affects localization EXP carvedilol affects the localization of HPCA protein CTD PMID:21078978 NCBI chr 5:147,295,124...147,305,757
Ensembl chr 5:147,294,820...147,303,346
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression EXP carvedilol results in increased expression of HSPH1 protein CTD PMID:20403466 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Ifng interferon gamma multiple interactions ISO carvedilol inhibits the reaction [Hemagglutinins results in increased expression of IFNG protein] CTD PMID:15229385 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP carvedilol inhibits the reaction [Doxorubicin results in increased expression of IKBKB protein] CTD PMID:26036690 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO
EXP
carvedilol inhibits the reaction [CSF2 results in increased expression of IL10 mRNA]; carvedilol inhibits the reaction [CSF2 results in increased expression of IL10 protein]
carvedilol results in increased expression of IL10 mRNA; carvedilol results in increased expression of IL10 protein
CTD PMID:12722941, PMID:16310260, PMID:18971572, PMID:20017808 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12a interleukin 12A multiple interactions ISO carvedilol promotes the reaction [Hemagglutinins results in increased expression of [IL12A protein binds to IL12B protein]]; carvedilol promotes the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:15229385 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO carvedilol promotes the reaction [Hemagglutinins results in increased expression of [IL12A protein binds to IL12B protein]]; carvedilol promotes the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:15229385 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
ISO
EXP
carvedilol results in decreased expression of IL1B mRNA
carvedilol results in decreased expression of IL1B mRNA; carvedilol results in decreased expression of IL1B protein
Carvedilol inhibits the reaction [Arginine results in increased expression of IL1B protein]; Carvedilol inhibits the reaction [Norepinephrine results in increased expression of IL1B mRNA]
carvedilol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD PMID:10722803, PMID:14684360, PMID:15921778, PMID:16310260, PMID:20017808, PMID:32569593 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression EXP carvedilol results in increased expression of IL1RN protein CTD PMID:20017808 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
EXP carvedilol results in decreased expression of IL6 mRNA; carvedilol results in decreased expression of IL6 protein
carvedilol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]
CTD PMID:10722803, PMID:11406463, PMID:16310260 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 decreases expression ISO carvedilol results in decreased expression of INS protein alternative form CTD PMID:16598518 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Jph2 junctophilin 2 increases expression ISO carvedilol results in increased expression of JPH2 protein CTD PMID:22375019 NCBI chr 3:159,709,998...159,776,536
Ensembl chr 3:159,712,325...159,775,643
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 multiple interactions EXP carvedilol binds to and results in decreased activity of KCNA5 protein CTD PMID:22146582 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
affects activity
ISO carvedilol results in decreased activity of KCNH2 protein
carvedilol affects the activity of KCNH2 protein
CTD PMID:11164846, PMID:16314852, PMID:22020101 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 decreases activity ISO carvedilol results in decreased activity of KCNJ11 protein CTD PMID:16325804 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 multiple interactions ISO carvedilol binds to and results in decreased activity of KCNJ4 protein; Phosphatidylinositol Phosphates inhibits the reaction [carvedilol binds to and results in decreased activity of KCNJ4 protein] CTD PMID:21663737 NCBI chr 7:120,717,378...120,744,602
Ensembl chr 7:120,717,375...120,744,602
JBrowse link
G Kcnk3 potassium two pore domain channel subfamily K member 3 decreases activity ISO carvedilol results in decreased activity of KCNK3 protein CTD PMID:21410455 NCBI chr 6:27,154,274...27,190,209
Ensembl chr 6:27,151,612...27,190,132
JBrowse link
G Klf13 Kruppel-like factor 13 multiple interactions EXP [[Oxygen deficiency co-treated with Glucose deficiency] results in increased susceptibility to Carvedilol] which results in decreased expression of KLF13 mRNA CTD PMID:29122578 NCBI chr 1:124,772,596...124,803,363
Ensembl chr 1:124,772,596...124,803,363
JBrowse link
G Lox lysyl oxidase decreases expression EXP carvedilol results in decreased expression of LOX mRNA CTD PMID:21216836 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
[Doxorubicin co-treated with carvedilol] results in increased phosphorylation of MAPK1 protein; carvedilol inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK1 protein]
Erlotinib Hydrochloride inhibits the reaction [carvedilol results in increased phosphorylation of MAPK1 protein]
[Carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Carvedilol results in increased phosphorylation of MAPK1 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ICI 118551 inhibits the reaction [[Carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]
CTD PMID:11054474, PMID:15306222, PMID:16213474, PMID:17925438, PMID:18787115 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP carvedilol inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK14 protein] CTD PMID:16213474 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
[Doxorubicin co-treated with carvedilol] results in increased phosphorylation of MAPK3 protein; carvedilol inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK3 protein]
carvedilol results in increased phosphorylation of MAPK3 protein
Erlotinib Hydrochloride inhibits the reaction [carvedilol results in increased phosphorylation of MAPK3 protein]
[Carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB1 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Carvedilol results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; HBEGF protein inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ICI 118551 inhibits the reaction [[Carvedilol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]
CTD PMID:11054474, PMID:15306222, PMID:16213474, PMID:17925438, PMID:18787115 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mfge8 milk fat globule EGF and factor V/VIII domain containing decreases expression EXP carvedilol results in decreased expression of MFGE8 protein CTD PMID:20403466 NCBI chr 1:140,845,478...140,860,882
Ensembl chr 1:140,845,465...140,860,894
JBrowse link
G Mir125a microRNA 125a multiple interactions
increases expression
ISO [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR125A mRNA
ARRB1 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR125A mRNA]; GRK5 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR125A mRNA]; GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR125A mRNA]
carvedilol results in increased expression of MIR125A mRNA
CTD PMID:24334028 NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911
JBrowse link
G Mir125b1 microRNA 125b-1 multiple interactions
increases expression
ISO ARRB1 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]; GRK5 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]; GRK6 gene mutant form inhibits the reaction [carvedilol results in increased expression of MIR125B-1 mRNA]
[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR125B-1 mRNA
CTD PMID:24334028 NCBI chr 8:45,798,260...45,798,346
Ensembl chr 8:45,798,260...45,798,346
JBrowse link
G Mir125b2 microRNA 125b-2 increases expression ISO Carvedilol results in increased expression of MIR125B2 mRNA CTD PMID:29122578 NCBI chr11:16,097,346...16,097,433 JBrowse link
G Mir150 microRNA 150 multiple interactions
increases expression
ISO [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR150 mRNA
ARRB1 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR150 mRNA]; GRK5 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR150 mRNA]; GRK6 gene mutant form inhibits the reaction [Carvedilol results in increased expression of MIR150 mRNA]
CTD PMID:24334028 NCBI chr 1:101,115,974...101,116,058
Ensembl chr 1:101,115,974...101,116,058
JBrowse link
G Mir190 microRNA 190 multiple interactions ISO [carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA; Colforsin inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; GRK5 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; GRK6 mutant form inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA]; Metoprolol inhibits the reaction [[carvedilol co-treated with ARRB1 protein] results in increased expression of MIR190A mRNA] CTD PMID:24334028 NCBI chr 8:73,030,047...73,030,131
Ensembl chr 8:73,030,047...73,030,131
JBrowse link
G Mir200a microRNA 200a multiple interactions EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in decreased expression of MIR200A mRNA] CTD PMID:30254303 NCBI chr 5:173,489,366...173,489,454 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression
EXP
ISO
carvedilol inhibits the reaction [Doxorubicin results in increased expression of MMP2 mRNA]
carvedilol results in decreased activity of MMP2 protein
carvedilol inhibits the reaction [TNF protein results in increased expression of MMP2 protein]
carvedilol results in decreased expression of MMP2
CTD PMID:16213474, PMID:16310260, PMID:17964422, PMID:20452391 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp8 matrix metallopeptidase 8 decreases expression ISO carvedilol results in decreased expression of MMP8 mRNA CTD PMID:15921778 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
JBrowse link
G Mmp9 matrix metallopeptidase 9 affects activity
decreases expression
decreases activity
multiple interactions
ISO
EXP
carvedilol affects the activity of MMP9 protein
carvedilol results in decreased expression of MMP9 mRNA
carvedilol results in decreased activity of MMP9 protein
carvedilol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
carvedilol inhibits the reaction [Doxorubicin results in increased expression of MMP9 mRNA]
CTD PMID:16213474, PMID:16310260, PMID:16574429, PMID:17964422, PMID:18971572 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
carvedilol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of MPO protein]
Carvedilol inhibits the reaction [Arginine results in increased expression of MPO protein]
carvedilol inhibits the reaction [Calcimycin results in increased secretion of MPO protein]; carvedilol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein]; carvedilol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MPO protein]
CTD PMID:16601795, PMID:17159805, PMID:18987595, PMID:32569593 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Msn moesin decreases expression EXP carvedilol results in decreased expression of MSN protein CTD PMID:20403466 NCBI chr  X:65,226,834...65,294,192
Ensembl chr  X:65,226,748...65,295,810
JBrowse link
G Mstn myostatin decreases expression EXP carvedilol results in decreased expression of MSTN mRNA; carvedilol results in decreased expression of MSTN protein CTD PMID:16968467 NCBI chr 9:53,310,977...53,315,804
Ensembl chr 9:53,309,598...53,315,915
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
affects expression
EXP carvedilol results in decreased expression of MYC protein
carvedilol affects the expression of MYC protein
CTD PMID:21472269, PMID:22000973 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myl12a myosin light chain 12A decreases expression EXP carvedilol results in decreased expression of MYL12A protein CTD PMID:20403466 NCBI chr 9:119,325,282...119,333,012
Ensembl chr 9:119,325,283...119,332,967
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 increases phosphorylation EXP carvedilol results in increased phosphorylation of NFATC4 protein CTD PMID:21472269 NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Atenolol inhibits the reaction [carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; carvedilol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; carvedilol inhibits the reaction [Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; carvedilol promotes the reaction [wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Prazosin inhibits the reaction [carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
carvedilol inhibits the reaction [Potassium Dichromate results in increased expression of NOS2 protein]
CTD PMID:17159805, PMID:19439816, PMID:25245570 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
increases phosphorylation
decreases expression
EXP carvedilol results in increased expression of NOS3 mRNA; carvedilol results in increased expression of NOS3 protein
carvedilol results in increased phosphorylation of NOS3 protein
carvedilol results in decreased expression of NOS3 mRNA
CTD PMID:16741616, PMID:17559835, PMID:18971572 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP carvedilol inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] CTD PMID:16213474 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin increases expression EXP Carvedilol results in increased expression of NPHS1 CTD PMID:20452391 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nppa natriuretic peptide A decreases expression
increases expression
decreases degradation
multiple interactions
ISO
EXP
carvedilol results in decreased expression of NPPA protein
carvedilol results in increased expression of NPPA mRNA; carvedilol results in increased expression of NPPA protein
carvedilol results in decreased expression of NPPA mRNA
carvedilol results in decreased degradation of NPPA protein
carvedilol inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; carvedilol promotes the reaction [NPPA protein results in increased abundance of Cyclic GMP]
CTD PMID:1378157, PMID:9421401, PMID:10722803, PMID:11206715, PMID:21216836 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression
increases expression
ISO
EXP
[carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein
carvedilol inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]
carvedilol results in decreased expression of NPPB protein
carvedilol results in decreased expression of NPPB mRNA; carvedilol results in decreased expression of NPPB protein
carvedilol results in increased expression of NPPB mRNA
CTD PMID:11206715, PMID:19367012, PMID:19650993, PMID:19692266, PMID:20413026, PMID:21055277, PMID:21378469, PMID:26036690 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Npr3 natriuretic peptide receptor 3 decreases expression EXP carvedilol results in decreased expression of NPR3 mRNA CTD PMID:9421401, PMID:11206715 NCBI chr 2:61,883,946...61,950,291
Ensembl chr 2:61,888,950...61,949,926
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions EXP carvedilol inhibits the reaction [Doxorubicin results in increased expression of OLR1 mRNA]; carvedilol inhibits the reaction [Doxorubicin results in increased expression of OLR1 protein]; carvedilol inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 mRNA]; carvedilol inhibits the reaction [Hydrogen Peroxide results in increased expression of OLR1 protein] CTD PMID:16055083 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO carvedilol results in decreased susceptibility to [PDGFB protein binds to PDGFB protein] CTD PMID:11904532 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pgd phosphogluconate dehydrogenase multiple interactions EXP carvedilol inhibits the reaction [Norepinephrine results in increased activity of PGD mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased activity of PGD protein] CTD PMID:1378361 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP carvedilol inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] CTD PMID:22413959 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP carvedilol results in increased expression of PPARGC1A mRNA CTD PMID:18971572 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prkca protein kinase C, alpha decreases expression EXP carvedilol results in decreased expression of PRKCA protein CTD PMID:20668454 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcd protein kinase C, delta decreases expression EXP carvedilol results in decreased expression of PRKCD protein CTD PMID:20668454 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkce protein kinase C, epsilon increases activity EXP carvedilol results in increased activity of PRKCE protein CTD PMID:16782078 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Ptafr platelet-activating factor receptor multiple interactions EXP Carvedilol inhibits the reaction [Arginine results in increased expression of PTAFR mRNA] CTD PMID:32569593 NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression EXP carvedilol results in decreased expression of PTGS1 mRNA CTD PMID:16741616 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP carvedilol inhibits the reaction [AGT protein affects the localization of RAC1 protein] CTD PMID:16940222 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Reg3b regenerating family member 3 beta multiple interactions EXP Carvedilol inhibits the reaction [Arginine results in increased expression of REG3B mRNA] CTD PMID:32569593 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Carvedilol inhibits the reaction [Arginine results in increased expression of RELA protein]; Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of RELA protein]; Carvedilol inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; Carvedilol inhibits the reaction [Potassium Dichromate affects the localization of RELA protein] CTD PMID:25245570, PMID:26036690, PMID:30254303, PMID:32569593 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin decreases expression ISO carvedilol results in decreased expression of REN protein CTD PMID:2454358 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Ryr2 ryanodine receptor 2 affects activity
increases expression
multiple interactions
increases activity
ISO
EXP
carvedilol affects the activity of RYR2 protein; carvedilol analog affects the activity of RYR2 protein
carvedilol results in increased expression of RYR2 protein
[Huang Qi co-treated with carvedilol] results in increased expression of RYR2 mRNA
carvedilol promotes the reaction [Perindopril results in increased expression of RYR2 protein]; Perindopril promotes the reaction [carvedilol results in increased expression of RYR2 protein]
carvedilol results in increased expression of RYR2 mRNA
carvedilol results in increased activity of RYR2 protein
carvedilol inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein]; carvedilol promotes the reaction [FKBP1B protein binds to RYR2 protein]
CTD PMID:12743001, PMID:19620082, PMID:21743453, PMID:21924056 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G S100a10 S100 calcium binding protein A10 decreases expression EXP carvedilol results in decreased expression of S100A10 protein CTD PMID:20403466 NCBI chr 2:193,892,589...193,901,236
Ensembl chr 2:193,892,589...193,901,236
JBrowse link
G S100a11 S100 calcium binding protein A11 decreases expression EXP carvedilol results in decreased expression of S100A11 protein CTD PMID:20403466 NCBI chr 2:193,863,185...193,868,646
Ensembl chr 2:193,866,951...193,868,502
JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression EXP carvedilol results in decreased expression of S100A6 protein CTD PMID:20403466 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions EXP carvedilol inhibits the reaction [Norepinephrine results in increased expression of SERPINH1 mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased expression of SERPINH1 protein] CTD PMID:10722803 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO carvedilol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Carvedilol inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Carvedilol inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Carvedilol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin] CTD PMID:19740083, PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO carvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; carvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] CTD PMID:21641380, PMID:21697722 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO carvedilol inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Smad7 SMAD family member 7 multiple interactions EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein] CTD PMID:30254303 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP carvedilol inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein] CTD PMID:26036690 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression EXP
ISO
carvedilol results in increased expression of SOX2 mRNA CTD PMID:27288437 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP carvedilol inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA] CTD PMID:22413959 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions EXP Carvedilol inhibits the reaction [Arginine results in increased expression of STAT1 protein] CTD PMID:32569593 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Terf2 telomeric repeat binding factor 2 affects expression EXP carvedilol affects the expression of TERF2 protein CTD PMID:22000973 NCBI chr19:39,271,992...39,301,506
Ensembl chr19:39,272,499...39,300,893
JBrowse link
G Tfpi tissue factor pathway inhibitor multiple interactions EXP [irbesartan co-treated with carvedilol] results in decreased expression of TFPI mRNA; [irbesartan co-treated with carvedilol] results in decreased expression of TFPI protein CTD PMID:21229253 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
decreases expression
multiple interactions
ISO
EXP
carvedilol results in decreased expression of TGFB1 mRNA
carvedilol decreases expression of TGFbeta mRNA in kidney of high fat high sodium diet fed SHRSP/A3N rats
carvedilol results in decreased expression of TGFB1 mRNA; carvedilol results in decreased expression of TGFB1 protein
Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TGFB1 mRNA]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]; Carvedilol inhibits the reaction [Sodium, Dietary results in increased expression of TGFB1 mRNA]
CTD PMID:11682445, PMID:11688356, PMID:12227681, PMID:15921778, PMID:16310260, PMID:19692266, PMID:22413959, PMID:30254303, PMID:11682445 RGD:30296650 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Th tyrosine hydroxylase multiple interactions
decreases expression
EXP carvedilol inhibits the reaction [Ethanol results in increased expression of TH protein]
carvedilol results in decreased expression of TH mRNA; carvedilol results in decreased expression of TH protein
CTD PMID:20359859, PMID:22413959 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression
EXP carvedilol inhibits the reaction [Ethanol results in increased expression of TIMP1 mRNA]; carvedilol inhibits the reaction [Ethanol results in increased expression of TIMP1 protein]
carvedilol results in decreased expression of TIMP1 mRNA
CTD PMID:21216836, PMID:22413959 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; carvedilol inhibits the reaction [TNF protein results in increased expression of MMP2 protein]; carvedilol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
carvedilol results in decreased expression of TNF mRNA; carvedilol results in decreased expression of TNF protein
Carvedilol inhibits the reaction [Arginine results in increased expression of TNF protein]; Carvedilol inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TNF protein]; Carvedilol inhibits the reaction [Potassium Dichromate results in increased expression of TNF protein]
CTD PMID:15229385, PMID:16310260, PMID:17964422, PMID:20017808, PMID:22413959, PMID:25245570, PMID:26036690, PMID:32569593 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 affects expression
multiple interactions
EXP carvedilol affects the expression of TP53 protein
carvedilol inhibits the reaction [Potassium Dichromate results in increased expression of TP53 protein]
CTD PMID:22000973, PMID:25245570 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txn1 thioredoxin 1 increases expression EXP carvedilol results in increased expression of TXN1 protein CTD PMID:20403466 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
affects metabolic processing
affects glucuronidation
ISO UGT1A1 protein results in increased glucuronidation of carvedilol
UGT1A1 gene polymorphism affects the metabolism of carvedilol
UGT1A1 gene polymorphism affects the glucuronidation of carvedilol
CTD PMID:14744946, PMID:16849011 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation
affects glucuronidation
affects metabolic processing
ISO UGT2B7 protein results in increased glucuronidation of carvedilol
UGT2B7 gene polymorphism affects the glucuronidation of carvedilol
UGT2B7 gene polymorphism affects the metabolism of carvedilol
CTD PMID:14744946, PMID:16849011, PMID:17329852 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Vim vimentin multiple interactions EXP Carvedilol inhibits the reaction [Carbon Tetrachloride results in increased expression of VIM protein]; Carvedilol inhibits the reaction [Streptozocin results in increased expression of VIM protein] CTD PMID:12140129, PMID:30254303 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
CGP 12177 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions
affects binding
increases activity
ISO
EXP
[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP; [CGP 12177 binds to and results in decreased activity of ADRB1 protein] which results in decreased abundance of Cyclic AMP; [CGP 12177 co-treated with ADRB1] results in increased abundance of Cyclic AMP; Alprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]; Bisoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Bisoprolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Bupranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Carvedilol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; CGP 12177 binds to and results in decreased activity of ADRB1 protein; CGP 12177 inhibits the reaction [cyanopindolol binds to ADRB1 protein]; CGP 12177 inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; CGP 20712A inhibits the reaction [[CGP 12177 co-treated with ADRB1] results in increased abundance of Cyclic AMP]; CGP 20712A inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]; Metoprolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Nadolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Nebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Oxprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Pindolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [CGP 12177 results in increased activity of ADRB1 protein]; Sotalol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]; Timolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP]
Atenolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; carvedilol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; CGP 20712A inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Labetalol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Nebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Pindolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Propranolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]
CTD PMID:2462161, PMID:9593075, PMID:10217540, PMID:12535855, PMID:12761341, PMID:14730417, PMID:15060759, PMID:17628611, PMID:21870877 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
affects binding
ISO
EXP
[CGP 12177 binds to and results in decreased activity of ADRB2 protein] which results in decreased abundance of Cyclic AMP; carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; CGP 12177 binds to and results in decreased activity of ADRB2 protein; CGP 12177 inhibits the reaction [cyanopindolol binds to ADRB2 protein]; N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide inhibits the reaction [CGP 12177 binds to ADRB2 protein]
Atenolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; carvedilol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; ICI 118551 inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Labetalol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Pindolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]; Propranolol inhibits the reaction [CGP 12177 binds to ADRB2 protein]
CTD PMID:2462161, PMID:9593075, PMID:12535855, PMID:14730417, PMID:17628611, PMID:21870877 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
affects binding
increases activity
affects response to substance
ISO
EXP
[CGP 12177 binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; CGP 12177 binds to and results in increased activity of ADRB3 protein; CGP 12177 inhibits the reaction [cyanopindolol binds to ADRB3 protein]; N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide inhibits the reaction [CGP 12177 binds to ADRB3 protein]
CGP 12177 results in increased activity of ADRB3 protein
ADRB3 affects the susceptibility to CGP 12177
3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [CGP 12177 results in increased activity of ADRB3 protein]; CGP 12177 binds to and results in increased activity of ADRB3 protein
CTD PMID:7815362, PMID:8569714, PMID:10217540, PMID:10952688, PMID:11159692, PMID:11753577, PMID:14730417, PMID:15563584, PMID:21870877 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [CGP 12177 results in increased activity of CFTR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CGP 12177 results in increased activity of CFTR protein]; Pertussis Toxin inhibits the reaction [CGP 12177 results in increased activity of CFTR protein]; U 0126 inhibits the reaction [CGP 12177 results in increased activity of CFTR protein]; wortmannin inhibits the reaction [CGP 12177 results in increased activity of CFTR protein] CTD PMID:15563584 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP GH1 protein promotes the reaction [CGP 12177 results in increased metabolism of Lipids] CTD PMID:14981226 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Lpl lipoprotein lipase increases expression EXP CGP 12177 results in increased expression of LPL mRNA CTD PMID:9032464 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity ISO CGP 12177 results in increased activity of MAPK1 protein CTD PMID:15563584 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity ISO CGP 12177 results in increased activity of MAPK3 protein CTD PMID:15563584 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Usf1 upstream transcription factor 1 multiple interactions ISO USF1 gene polymorphism promotes the reaction [CGP 12177 results in increased metabolism of Lipids]; USF1 protein affects the reaction [CGP 12177 results in increased metabolism of Lipids] CTD PMID:15985485 NCBI chr13:89,797,750...89,805,561
Ensembl chr13:89,797,800...89,805,558
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO CGP 12177 results in increased expression of VEGFA mRNA CTD PMID:10788502 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
clenbuterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO Clenbuterol results in increased expression of ACADM mRNA CTD PMID:17446185 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO
EXP
[Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose; ICI 118551 inhibits the reaction [[Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose] CTD PMID:16007677, PMID:18552870 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions EXP Clenbuterol binds to and results in increased activity of ADRB3 protein CTD PMID:7815362 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT1 protein] CTD PMID:16339297 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein] CTD PMID:16339297 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Akt3 AKT serine/threonine kinase 3 multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein] CTD PMID:16339297 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]] CTD PMID:15710352 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]] CTD PMID:15710352 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Esrra estrogen related receptor, alpha increases expression ISO Clenbuterol results in increased expression of ESRRA mRNA CTD PMID:17446185 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP Clenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]; Clenbuterol inhibits the reaction [Reserpine results in increased expression of GAD1 mRNA]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]] CTD PMID:8774452 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Il10 interleukin 10 multiple interactions
affects expression
ISO
EXP
Clenbuterol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL10 protein]
Clenbuterol affects the expression of IL10 protein
CTD PMID:15021963, PMID:15502056 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il18 interleukin 18 increases expression ISO Clenbuterol results in increased expression of IL18 mRNA; Clenbuterol results in increased expression of IL18 protein CTD PMID:15178407 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:15021963 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:15021963 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Clenbuterol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] CTD PMID:15502056 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases stability
increases activity
ISO Alprenolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]; Metoprolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]; Propranolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]
Clenbuterol results in increased stability of ODC1 protein
CTD PMID:10353628 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO Clenbuterol results in increased expression of PDK4 mRNA CTD PMID:17446185 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions
ISO
EXP
Clenbuterol results in increased expression of PPARGC1A mRNA
Propranolol inhibits the reaction [Clenbuterol results in increased expression of PPARGC1A mRNA]
CTD PMID:17446185 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein] CTD PMID:16339297 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Clenbuterol affects the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:15710352 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Clenbuterol results in increased expression of TFAM mRNA CTD PMID:17446185 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:15021963, PMID:15710352 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ucp1 uncoupling protein 1 increases expression ISO Clenbuterol results in increased expression of UCP1 protein CTD PMID:10465291 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
clorprenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO clorprenaline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
diazoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases localization
multiple interactions
EXP Diazoxide results in decreased localization of AIFM1 protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased localization of AIFM1 protein]
CTD PMID:21256120 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased phosphorylation of AKT1 protein] CTD PMID:21256120 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Diazoxide inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:20650802 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Diazoxide inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:20650802 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
ISO 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased expression of BCL2L1 mRNA alternative form]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased expression of BCL2L1 protein alternative form]
Diazoxide results in increased expression of BCL2L1 mRNA alternative form; Diazoxide results in increased expression of BCL2L1 protein alternative form
CTD PMID:15326191 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
EXP 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased activity of CASP3 protein] CTD PMID:21256120 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Diazoxide inhibits the reaction [CTNNB1 protein results in increased activity of CCND1 promoter]
Diazoxide results in decreased expression of CCND1 mRNA
CTD PMID:19052819 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO Diazoxide inhibits the reaction [CTNNB1 protein results in increased activity of CCND1 promoter]
Diazoxide results in decreased expression of CTNNB1 protein
CTD PMID:19052819 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cycs cytochrome c, somatic decreases secretion
multiple interactions
EXP Diazoxide results in decreased secretion of CYCS protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased secretion of CYCS protein]
CTD PMID:21256120 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]; Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]; HMOX1 protein affects the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]; zinc protoporphyrin inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Gcg glucagon multiple interactions ISO Diazoxide inhibits the reaction [gatifloxacin results in increased secretion of GCG protein] CTD PMID:23200776 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions ISO [Potassium Chloride co-treated with Diazoxide] inhibits the reaction [[GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein]] CTD PMID:10464266 NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Diazoxide inhibits the reaction [Oxygen deficiency results in decreased expression of HMOX1 mRNA]; Diazoxide inhibits the reaction [Oxygen deficiency results in decreased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Iapp islet amyloid polypeptide multiple interactions EXP Diazoxide inhibits the reaction [Glucose results in increased expression of IAPP mRNA] CTD PMID:9142872 NCBI chr 4:176,509,863...176,517,903
Ensembl chr 4:176,510,696...176,516,083
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Diazoxide results in decreased secretion of IL10 protein CTD PMID:16612254 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il6 interleukin 6 decreases secretion ISO Diazoxide results in decreased secretion of IL6 protein CTD PMID:16612254 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 decreases expression ISO Diazoxide results in decreased expression of KCNJ11 mRNA CTD PMID:23200776 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Lep leptin multiple interactions
decreases secretion
EXP Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]
Diazoxide results in decreased secretion of LEP protein
CTD PMID:10780946 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions ISO Diazoxide inhibits the reaction [Glucose results in increased secretion of NAMPT protein] CTD PMID:23536823 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases activity
ISO 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased activity of NFKB1 protein] CTD PMID:15326191 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]]; Diazoxide inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased activity of NOS2 protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]]; Diazoxide inhibits the reaction [Rotenone results in increased activity of NOS2 protein]; Diazoxide inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]
CTD PMID:15795934, PMID:15927086, PMID:16257489 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions EXP Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of PDX1 mRNA] CTD PMID:11527545 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions EXP Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of SLC2A2 mRNA] CTD PMID:11527545 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions
ISO
EXP
Diazoxide results in decreased secretion of TNF protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of TNF protein]]; Diazoxide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]; Diazoxide inhibits the reaction [Rotenone results in increased expression of TNF protein]
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased secretion of TNF protein]]; Diazoxide inhibits the reaction [Rotenone results in increased secretion of TNF protein]
CTD PMID:16257489, PMID:16612254, PMID:18700057, PMID:19012619 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Diazoxide results in decreased expression of TP53 mRNA CTD PMID:16426753 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
dobutamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Dobutamine results in decreased activity of ABCB11 protein CTD PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Adcy6 adenylate cyclase 6 affects response to substance ISO ADCY6 protein affects the susceptibility to Dobutamine CTD PMID:12393090 NCBI chr 7:140,270,678...140,291,722
Ensembl chr 7:140,270,692...140,291,620
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO Dobutamine binds to and results in increased activity of ADRA2A protein CTD PMID:16024912 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adrb1 adrenoceptor beta 1 affects response to substance
multiple interactions
ISO
EXP
ADRB1 gene affects the susceptibility to Dobutamine; ADRB1 gene polymorphism affects the susceptibility to Dobutamine; ADRB1 protein polymorphism affects the susceptibility to Dobutamine
[Dobutamine co-treated with ICI 118551] results in decreased expression of ADRB1 mRNA; [Dobutamine co-treated with ICI 118551] results in decreased expression of ADRB1 protein; Dobutamine binds to and results in increased activity of ADRB1 protein; Dobutamine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Oxygen deficiency results in increased susceptibility to [Dobutamine binds to and results in increased activity of ADRB1 protein]
ADRB1 gene polymorphism affects the susceptibility to [Dobutamine co-treated with Metoprolol]; AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Dobutamine binds to and results in increased activity of ADRB1 protein; Dobutamine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
CTD PMID:8096834, PMID:10192281, PMID:11753577, PMID:14502278, PMID:15564877, PMID:16024912, PMID:18787115, PMID:19719783, PMID:20821015, PMID:21311897 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 affects response to substance ISO ADRB2 gene polymorphism affects the susceptibility to Dobutamine CTD PMID:17094270 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions EXP [Dobutamine co-treated with ICI 118551] results in increased expression of ADRB3 mRNA; [Dobutamine co-treated with ICI 118551] results in increased expression of ADRB3 protein CTD PMID:19719783 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Ahsg alpha-2-HS-glycoprotein affects response to substance ISO AHSG protein affects the susceptibility to Dobutamine CTD PMID:16177000 NCBI chr11:81,711,269...81,717,594 JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects response to substance
multiple interactions
ISO
EXP
AKT1 protein affects the susceptibility to Dobutamine
Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT1 protein]
CTD PMID:16094411, PMID:16339297 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein] CTD PMID:16339297 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Akt3 AKT serine/threonine kinase 3 multiple interactions EXP Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein] CTD PMID:16339297 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]] CTD PMID:18787115 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]] CTD PMID:18787115 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Dobutamine results in increased expression of BAX protein CTD PMID:15052282 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Dobutamine results in decreased expression of BCL2 protein CTD PMID:15052282 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bnip1 BCL2 interacting protein 1 increases expression ISO Dobutamine results in increased expression of BNIP1 protein CTD PMID:15052282 NCBI chr10:16,677,077...16,689,321
Ensembl chr10:16,677,077...16,689,321
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:12818967 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein] CTD PMID:12818968 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Clu clusterin increases expression ISO Dobutamine results in increased expression of CLU protein CTD PMID:15052282 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Comt catechol-O-methyltransferase increases methylation
increases expression
ISO
EXP
COMT protein results in increased methylation of Dobutamine
Dobutamine results in increased expression of COMT mRNA
CTD PMID:11160877, PMID:12423672 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Dobutamine results in increased expression of CPT1A mRNA; Dobutamine results in increased expression of CPT1A protein CTD PMID:8479178 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Crem cAMP responsive element modulator affects response to substance ISO CREM protein affects the susceptibility to Dobutamine CTD PMID:12475904 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Ctf1 cardiotrophin 1 affects response to substance ISO CTF1 protein affects the susceptibility to Dobutamine CTD PMID:17150369 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA] CTD PMID:11605937 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Dbh dopamine beta-hydroxylase affects response to substance ISO DBH protein affects the susceptibility to Dobutamine CTD PMID:10338466 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Dmd dystrophin increases response to substance ISO DMD gene mutant form results in increased susceptibility to Dobutamine CTD PMID:17440445 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Egfr epidermal growth factor receptor decreases response to substance
multiple interactions
ISO EGFR gene mutant form results in decreased susceptibility to Dobutamine
AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
CTD PMID:18599591, PMID:18787115 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Dobutamine binds to and results in increased activity of ESR1 protein CTD PMID:24928891 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Dobutamine results in increased expression of F3 protein CTD PMID:16286589 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fgf2 fibroblast growth factor 2 affects response to substance ISO FGF2 protein affects the susceptibility to Dobutamine CTD PMID:10491406, PMID:14583313 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]; Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]] CTD PMID:15179140 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Dobutamine results in increased activity of G6PD protein CTD PMID:1978808 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP GH1 protein promotes the reaction [Dobutamine results in increased metabolism of Lipids] CTD PMID:14981226 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gk glycerol kinase increases activity EXP Dobutamine results in increased activity of GK protein CTD PMID:12736183 NCBI chr  X:54,227,291...54,303,897
Ensembl chr  X:54,227,397...54,303,864
JBrowse link
G Gnas GNAS complex locus increases response to substance ISO GNAS gene SNP results in increased susceptibility to Dobutamine CTD PMID:19542315 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects response to substance ISO GSK3B gene mutant form affects the susceptibility to Dobutamine CTD PMID:17901358 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]] CTD PMID:18787115 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP esmolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 protein]; Metoprolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 mRNA]; Metoprolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased expression of HMOX1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased expression of HMOX1 protein]
Dobutamine results in increased expression of HMOX1 mRNA; Dobutamine results in increased expression of HMOX1 protein
CTD PMID:15179140, PMID:16627864 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Igf1 insulin-like growth factor 1 increases response to substance EXP IGF1 protein results in increased susceptibility to Dobutamine CTD PMID:17184500 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Dobutamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL10 protein]
Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]
CTD PMID:11605937, PMID:15502056 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Dobutamine results in increased expression of IL1B mRNA CTD PMID:9387890 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
decreases expression
multiple interactions
ISO
EXP
Dobutamine results in increased expression of IL6 protein
Dobutamine results in decreased expression of IL6 mRNA
Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:11605937, PMID:12423672, PMID:16286589 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb1 integrin subunit beta 1 affects response to substance ISO ITGB1 protein affects the susceptibility to Dobutamine CTD PMID:11884376 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]; Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]] CTD PMID:15179140 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]; Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]] CTD PMID:15179140 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Dobutamine results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions
affects response to substance
ISO KCNJ11 protein affects the reaction [[Manganese co-treated with Dobutamine] results in increased abundance of Calcium]
KCNJ11 protein affects the susceptibility to Dobutamine
CTD PMID:17189350 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Klk1 kallikrein 1 affects response to substance ISO KLK1 protein affects the susceptibility to Dobutamine CTD PMID:12411458 NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
JBrowse link
G Lep leptin decreases secretion
decreases expression
ISO Dobutamine results in decreased secretion of LEP protein
Dobutamine results in decreased expression of LEP mRNA; Dobutamine results in decreased expression of LEP protein
CTD PMID:9002984, PMID:11022189 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor affects response to substance ISO LEPR protein affects the susceptibility to Dobutamine CTD PMID:20175764 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
[Dobutamine co-treated with ICI 118551] results in increased activity of MAPK1 protein
AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]
Dobutamine results in increased phosphorylation of MAPK1 protein
CTD PMID:16760913, PMID:18787115, PMID:19719783 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
[Dobutamine co-treated with ICI 118551] results in increased activity of MAPK3 protein
AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]
Dobutamine results in increased phosphorylation of MAPK3 protein
CTD PMID:16760913, PMID:18787115, PMID:19719783 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP [Dobutamine co-treated with ICI 118551] results in increased activity of MAPK9 protein CTD PMID:19719783 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mb myoglobin affects response to substance ISO MB protein affects the susceptibility to Dobutamine CTD PMID:10468637 NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Dobutamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] CTD PMID:15502056 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos1 nitric oxide synthase 1 affects response to substance ISO NOS1 protein affects the susceptibility to Dobutamine CTD PMID:16344403 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 affects response to substance ISO NOS2 protein affects the susceptibility to Dobutamine CTD PMID:9396439, PMID:11489778 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO Dobutamine results in increased activity of NR1H4 protein CTD PMID:22414727 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP Dobutamine results in increased expression of PHGDH mRNA CTD PMID:12423672 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Pln phospholamban affects response to substance ISO PLN protein affects the susceptibility to Dobutamine CTD PMID:14991071 NCBI chr20:34,633,157...34,642,904
Ensembl chr20:34,633,157...34,642,904
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha affects response to substance ISO PPP2CA protein affects the susceptibility to Dobutamine CTD PMID:15247211 NCBI chr10:37,534,449...37,554,861
Ensembl chr10:37,535,871...37,554,664
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein] CTD PMID:16339297 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Prkce protein kinase C, epsilon affects response to substance ISO PRKCE protein affects the susceptibility to Dobutamine CTD PMID:15242976 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Prop1 PROP paired-like homeobox 1 decreases response to substance ISO PROP1 gene mutant form results in decreased susceptibility to Dobutamine CTD PMID:19414510 NCBI chr10:36,449,920...36,452,381
Ensembl chr10:36,449,920...36,452,378
JBrowse link
G Ren renin multiple interactions
increases expression
increases secretion
increases activity
ISO Cycloheximide inhibits the reaction [Dobutamine results in increased secretion of REN protein]; Dactinomycin inhibits the reaction [Dobutamine results in increased secretion of REN protein]
Dobutamine results in increased expression of REN mRNA
Dobutamine results in increased activity of REN protein
CTD PMID:9203624, PMID:9209250 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G S100a1 S100 calcium binding protein A1 increases response to substance ISO S100A1 gene mutant form results in increased susceptibility to Dobutamine CTD PMID:18645228 NCBI chr 2:189,900,505...189,905,348
Ensembl chr 2:189,900,667...189,903,219
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma increases expression EXP Dobutamine results in increased expression of SCNN1G mRNA CTD PMID:16638327 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
JBrowse link
G Sgcd sarcoglycan, delta affects response to substance ISO SGCD affects the susceptibility to Dobutamine CTD PMID:20675662 NCBI chr10:32,062,946...32,471,454
Ensembl chr10:32,062,946...32,471,454
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases degradation EXP Dobutamine deficiency results in increased degradation of SPTAN1 protein CTD PMID:15849228 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions ISO Dobutamine promotes the reaction [TAC1 protein binds to and results in increased activity of TACR1 protein] CTD PMID:8994422 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions ISO Dobutamine promotes the reaction [TAC1 protein binds to and results in increased activity of TACR1 protein] CTD PMID:8994422 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP Dobutamine results in increased expression of TGFB1 mRNA CTD PMID:16760913 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Dobutamine results in increased expression of TGFB2 mRNA CTD PMID:16760913 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tnf tumor necrosis factor decreases expression
decreases secretion
EXP Dobutamine results in decreased expression of TNF mRNA
Dobutamine results in decreased secretion of TNF protein
CTD PMID:12423672 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Usf1 upstream transcription factor 1 multiple interactions ISO USF1 gene polymorphism promotes the reaction [Dobutamine results in increased metabolism of Lipids]; USF1 protein affects the reaction [Dobutamine results in increased metabolism of Lipids] CTD PMID:15985485 NCBI chr13:89,797,750...89,805,561
Ensembl chr13:89,797,800...89,805,558
JBrowse link
G Vegfa vascular endothelial growth factor A affects response to substance ISO VEGFA protein affects the susceptibility to Dobutamine CTD PMID:11599061, PMID:14583313, PMID:19237429 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
dopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A3galt2 alpha 1,3-galactosyltransferase 2 increases expression EXP Dopamine results in increased expression of A3GALT2 mRNA CTD PMID:21983523 NCBI chr 5:146,933,592...146,945,882
Ensembl chr 5:146,933,592...146,945,880
JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase decreases expression EXP Dopamine results in decreased expression of ABL2 mRNA CTD PMID:21983523 NCBI chr13:74,154,533...74,333,244
Ensembl chr13:74,154,835...74,333,244
JBrowse link
G Actb actin, beta affects expression ISO Dopamine affects the expression of ACTB protein CTD PMID:24675778 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Actbl2 actin, beta-like 2 decreases expression ISO Dopamine results in decreased expression of ACTBL2 protein CTD PMID:24675778 NCBI chr 2:42,829,413...42,832,160
Ensembl chr 2:42,829,413...42,832,160
JBrowse link
G Actg1 actin, gamma 1 increases expression EXP Dopamine results in increased expression of ACTG1 mRNA CTD PMID:21983523 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 increases expression EXP Dopamine results in increased expression of ADAM9 mRNA CTD PMID:21983523 NCBI chr16:71,810,377...71,887,926
Ensembl chr16:71,810,377...71,887,926
JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 increases expression EXP Dopamine results in increased expression of ADAMTS4 mRNA CTD PMID:21983523 NCBI chr13:89,622,996...89,632,485
Ensembl chr13:89,622,632...89,634,419
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions EXP [N(6)-cyclohexyladenosine binds to and results in increased activity of ADORA1 protein] promotes the reaction [Methamphetamine results in increased secretion of Dopamine] CTD PMID:11043458 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adra2a adrenoceptor alpha 2A affects binding ISO Dopamine binds to ADRA2A protein CTD PMID:10336518 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2c adrenoceptor alpha 2C affects binding ISO Dopamine binds to ADRA2C protein CTD PMID:10336518 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions EXP [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine] CTD PMID:10894789 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Agt angiotensinogen multiple interactions ISO Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]]; Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]; Raclopride inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]] CTD PMID:11549694 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [[CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline] inhibits the reaction [Cocaine results in increased abundance of and results in increased secretion of Dopamine]; ALDH2 protein affects the reaction [Cocaine results in increased abundance of Dopamine] CTD PMID:20729865 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression ISO Dopamine results in increased expression of ALDOA protein CTD PMID:24675778 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Anxa3 annexin A3 increases expression ISO Dopamine results in increased expression of ANXA3 protein CTD PMID:24675778 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Arg1 arginase 1 decreases expression EXP Dopamine results in decreased expression of ARG1 mRNA; Dopamine results in decreased expression of ARG1 protein CTD PMID:25818600 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 decreases expression EXP Dopamine results in decreased expression of ATP2B2 mRNA CTD PMID:21983523 NCBI chr 4:145,704,779...145,948,997
Ensembl chr 4:145,703,046...146,016,325
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d increases expression ISO Dopamine results in increased expression of ATP5PD protein CTD PMID:24675778 NCBI chr10:103,967,340...103,972,552
Ensembl chr10:103,967,312...103,972,668
JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 increases expression EXP Dopamine results in increased expression of B4GALT1 mRNA CTD PMID:21983523 NCBI chr 5:57,121,768...57,168,610
Ensembl chr 5:57,121,769...57,168,610
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO Dopamine results in decreased expression of BAX protein CTD PMID:19410601 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO [Dopamine results in increased expression of HIF1A protein] which results in increased expression of BBC3 mRNA; [Dopamine results in increased expression of HIF1A protein] which results in increased expression of BBC3 protein CTD PMID:19410601 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Dopamine results in decreased expression of BCL2 protein
polydatin inhibits the reaction [Dopamine results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [Dopamine results in decreased expression of BCL2 protein]
CTD PMID:17603292, PMID:28980048 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor increases abundance ISO BDNF gene mutant form results in increased abundance of Dopamine CTD PMID:11421589 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO [Dopamine results in increased expression of HIF1A protein] which results in increased expression of BNIP3 mRNA; [Dopamine results in increased expression of HIF1A protein] which results in increased expression of BNIP3 protein CTD PMID:19410601 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G C1qbp complement C1q binding protein increases expression ISO Dopamine results in increased expression of C1QBP protein CTD PMID:24675778 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Calu calumenin increases expression EXP Dopamine results in increased expression of CALU mRNA CTD PMID:21983523 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Caly calcyon neuron-specific vesicular protein decreases secretion ISO CALY protein results in decreased secretion of Dopamine CTD PMID:30753204 NCBI chr 1:212,537,851...212,549,040
Ensembl chr 1:212,537,848...212,549,477
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP [Ionomycin co-treated with CAMK2A protein] inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]] CTD PMID:19217379 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
ISO
EXP
[Dopamine co-treated with Zinc deficiency] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Dopamine results in increased activity of and results in increased cleavage of CASP3 protein]; Dopamine results in increased activity of and results in increased cleavage of CASP3 protein; Dopamine results in increased cleavage of and results in increased activity of CASP3 protein; PRKN protein inhibits the reaction [Dopamine results in increased cleavage of CASP3 protein]; resveratrol inhibits the reaction [Dopamine results in increased cleavage of and results in increased activity of CASP3 protein]
Dopamine results in increased activity of CASP3 protein
SH-6 compound promotes the reaction [Dopamine results in increased activity of CASP3 protein]; SH-6 compound promotes the reaction [tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]]; tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]
CTD PMID:15198987, PMID:17136323, PMID:17603292, PMID:18194434, PMID:19410601, PMID:22987761, PMID:23377617 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [Dopamine results in increased activity of and results in increased cleavage of CASP7 protein]; Dopamine results in increased activity of and results in increased cleavage of CASP7 protein
Dopamine results in increased activity of CASP7 protein
CTD PMID:17136323, PMID:19410601 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cat catalase multiple interactions
increases expression
ISO
EXP
CAT protein inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased abundance of Dopamine]
Dopamine results in increased expression of CAT mRNA
[Dopamine co-treated with Dicumarol] results in increased expression of CAT mRNA
CTD PMID:11299314, PMID:11435997 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbx7