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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:xaliproden
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Accession:CHEBI:48520 term browser browse the term
Definition:A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine which is substituted on the nitrogen by a 2-(2-naphthyl)ethyl group and at position 4 by a m-trifluoromethylphenyl group.
Synonyms:exact_synonym: 1-[2-(2-naphthyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine
 related_synonym: 1,2,3,6-tetrahydro-1-(2-(2-naphthalenyl)ethyl)-4-(3-(trifluoromethyl)phenyl)-pyridine;   1,2,3,6-tetrahydro-1-(2-(2-naphthyl)ethyl)-4-(alpha,alpha,alpha-trifluoro-m-tolyl)pyridine;   Formula=C24H22F3N;   InChI=1S/C24H22F3N/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18/h1-9,11,16-17H,10,12-15H2;   InChIKey=WJJYZXPHLSLMGE-UHFFFAOYSA-N;   SMILES=FC(F)(F)c1cccc(c1)C1=CCN(CCc2ccc3ccccc3c2)CC1
 xref: Beilstein:8164054;   CAS:135354-02-8;   Drug_Central:4367;   KEGG:D06327;   LINCS:LSM-3966
 xref_mesh: MESH:C462299
 xref: Patent:EP101381;   Patent:US4521428


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xaliproden term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP xaliproden inhibits the reaction [Vincristine results in decreased expression of ACHE protein] CTD PMID:8413926 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO xaliproden results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          neurotransmitter agent 16425
            serotonergic drug 3957
              serotonergic agonist 978
                xaliproden 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            organic hydride 18249
                              organic fundamental parent 18249
                                hydrocarbon 17969
                                  halohydrocarbon 13937
                                    haloalkane 11657
                                      fluoroalkane 7110
                                        fluoromethanes 6330
                                          tetrafluoromethane 6330
                                            trifluoromethyl group 6330
                                              (trifluoromethyl)benzenes 6330
                                                xaliproden 2
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