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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:xaliproden
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Accession:CHEBI:48520 term browser browse the term
Definition:A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine which is substituted on the nitrogen by a 2-(2-naphthyl)ethyl group and at position 4 by a m-trifluoromethylphenyl group.
Synonyms:exact_synonym: 1-[2-(2-naphthyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine
 related_synonym: 1,2,3,6-tetrahydro-1-(2-(2-naphthalenyl)ethyl)-4-(3-(trifluoromethyl)phenyl)-pyridine;   1,2,3,6-tetrahydro-1-(2-(2-naphthyl)ethyl)-4-(alpha,alpha,alpha-trifluoro-m-tolyl)pyridine;   Formula=C24H22F3N;   InChI=1S/C24H22F3N/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18/h1-9,11,16-17H,10,12-15H2;   InChIKey=WJJYZXPHLSLMGE-UHFFFAOYSA-N;   SMILES=FC(F)(F)c1cccc(c1)C1=CCN(CCc2ccc3ccccc3c2)CC1
 xref: Beilstein:8164054;   CAS:135354-02-8;   Drug_Central:4367;   KEGG:D06327;   LINCS:LSM-3966
 xref_mesh: MESH:C462299
 xref: Patent:EP101381;   Patent:US4521428


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xaliproden term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP xaliproden inhibits the reaction [Vincristine results in decreased expression of ACHE protein] CTD PMID:8413926 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO xaliproden results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link

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  CHEBI ontology 19808
    role 19757
      biological role 19757
        pharmacological role 18838
          neurotransmitter agent 16452
            serotonergic drug 3980
              serotonergic agonist 983
                xaliproden 2
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  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    main group molecular entity 19704
                      s-block molecular entity 19489
                        hydrogen molecular entity 19484
                          hydrides 18841
                            organic hydride 18350
                              organic fundamental parent 18350
                                hydrocarbon 18061
                                  halohydrocarbon 14052
                                    haloalkane 11707
                                      fluoroalkane 7214
                                        fluoromethanes 6411
                                          tetrafluoromethane 6411
                                            trifluoromethyl group 6411
                                              (trifluoromethyl)benzenes 6411
                                                xaliproden 2
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