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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pyrimidinecarboxamide
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Accession:CHEBI:48438 term browser browse the term
Synonyms:related_synonym: pyrimidinecarboxamides


show annotations for term's descendants           Sort by:
copanlisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO copanlisib results in decreased phosphorylation of AKT1 protein CTD PMID:31445927 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO copanlisib affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO copanlisib results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
ricolinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO ricolinostat promotes the reaction [Bortezomib results in increased cleavage of CASP3 protein] CTD PMID:22262760 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO ricolinostat promotes the reaction [Bortezomib results in increased cleavage of CASP8 protein] CTD PMID:22262760 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [ricolinostat co-treated with Bortezomib] results in increased cleavage of CASP9 protein CTD PMID:22262760 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation		 ISO Bortezomib promotes the reaction [ricolinostat results in increased phosphorylation of EIF2AK3 protein] CTD PMID:22262760 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation		 ISO Bortezomib affects the reaction [ricolinostat results in increased phosphorylation of EIF2S1 protein] CTD PMID:22262760 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
affects phosphorylation		 ISO Bortezomib affects the reaction [ricolinostat affects the phosphorylation of ERN1 protein] CTD PMID:22262760 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Esrra estrogen related receptor, alpha decreases expression ISO ricolinostat results in decreased expression of ESRRA protein CTD PMID:34524571 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Hdac6 histone deacetylase 6 decreases activity ISO ricolinostat results in decreased activity of HDAC6 protein CTD PMID:22262760 PMID:34524571 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO ricolinostat promotes the reaction [Bortezomib results in increased cleavage of PARP1 protein] CTD PMID:22262760 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO [ricolinostat co-treated with Bortezomib] results in increased expression of XBP1 protein alternative form CTD PMID:22262760 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    chemical entity 19919
      atom 19919
        nonmetal atom 19848
          nitrogen atom 19027
            nitrogen molecular entity 19027
              organonitrogen compound 18877
                carboxamide 17577
                  monocarboxylic acid amide 15748
                    pyrimidinecarboxamide 13
                      (4R)-1-benzyl-N-hydroxy-3-[(4-methoxyphenyl)sulfonyl]-6-oxohexahydropyrimidine-4-carboxamide 0
                      5-chloro-2-[(3-methylphenyl)methylsulfonyl]-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)-4-pyrimidinecarboxamide 0
                      5-chloro-2-[(4-methylphenyl)methylsulfonyl]-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)-4-pyrimidinecarboxamide 0
                      5-chloro-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-(phenylmethyl)sulfonyl-4-pyrimidinecarboxamide 0
                      5-chloro-N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-2-[(4-fluorophenyl)methylsulfonyl]-4-pyrimidinecarboxamide 0
                      Echiguanine B 0
                      N,N'-bis(3-methylbenzyl)pyrimidine-4,6-dicarboxamide 0
                      N,N'-bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide 0
                      N,N'-bis(pyridin-3-ylmethyl)pyrimidine-4,6-dicarboxamide 0
                      N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethylhexahydropyrimidine-2-carboxamide 0
                      TAK-580 0
                      ZCAN262 0
                      copanlisib + 3
                      ricolinostat 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            heteroorganic entity 19558
                              organochalcogen compound 19317
                                organooxygen compound 19233
                                  carbon oxoacid 18695
                                    carboxylic acid 18692
                                      carboacyl group 17724
                                        univalent carboacyl group 17724
                                          carbamoyl group 17577
                                            carboxamide 17577
                                              monocarboxylic acid amide 15748
                                                pyrimidinecarboxamide 13
                                                  (4R)-1-benzyl-N-hydroxy-3-[(4-methoxyphenyl)sulfonyl]-6-oxohexahydropyrimidine-4-carboxamide 0
                                                  5-chloro-2-[(3-methylphenyl)methylsulfonyl]-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)-4-pyrimidinecarboxamide 0
                                                  5-chloro-2-[(4-methylphenyl)methylsulfonyl]-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)-4-pyrimidinecarboxamide 0
                                                  5-chloro-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-(phenylmethyl)sulfonyl-4-pyrimidinecarboxamide 0
                                                  5-chloro-N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-2-[(4-fluorophenyl)methylsulfonyl]-4-pyrimidinecarboxamide 0
                                                  Echiguanine B 0
                                                  N,N'-bis(3-methylbenzyl)pyrimidine-4,6-dicarboxamide 0
                                                  N,N'-bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide 0
                                                  N,N'-bis(pyridin-3-ylmethyl)pyrimidine-4,6-dicarboxamide 0
                                                  N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethylhexahydropyrimidine-2-carboxamide 0
                                                  TAK-580 0
                                                  ZCAN262 0
                                                  copanlisib + 3
                                                  ricolinostat 10
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