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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cinacalcet
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Accession:CHEBI:48390 term browser browse the term
Definition:A secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group.
Synonyms:exact_synonym: N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
 related_synonym: (R)-alpha-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine;   CNC;   Formula=C22H22F3N;   InChI=1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1;   InChIKey=VDHAWDNDOKGFTD-MRXNPFEDSA-N;   Mimpara;   N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine;   SMILES=C[C@@H](NCCCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12
 xref: CAS:226256-56-0;   DrugBank:DB01012;   Drug_Central:647;   KEGG:D03504;   LINCS:LSM-5815
 xref_mesh: MESH:D000069449
 xref: PMID:16680561;   PMID:17652181;   Patent:US2007060645;   Patent:US6011068;   Patent:US6211244;   Reaxys:10191346;   Wikipedia:Cinacalcet


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cinacalcet term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Cinacalcet results in decreased activity of CYP2D6 protein CTD PMID:16680561 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Cinacalcet results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Pth parathyroid hormone decreases expression
decreases secretion
multiple interactions
ISO Cinacalcet results in decreased expression of PTH protein
Cinacalcet results in decreased secretion of PTH protein
[Cinacalcet co-treated with Vitamin D] results in decreased expression of PTH protein
CTD PMID:17060004 PMID:18256372 PMID:21541686 PMID:22118402 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        pharmaceutical 19319
          drug 19319
            calcimimetic 3
              cinacalcet 3
                cinacalcet carbamate 0
                cinacalcet hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            organic hydride 18354
                              organic fundamental parent 18354
                                hydrocarbon 18065
                                  halohydrocarbon 14053
                                    haloalkane 11708
                                      fluoroalkane 7215
                                        fluoromethanes 6410
                                          tetrafluoromethane 6410
                                            trifluoromethyl group 6410
                                              (trifluoromethyl)benzenes 6410
                                                cinacalcet 3
                                                  cinacalcet carbamate 0
                                                  cinacalcet hydrochloride 0
paths to the root