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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cinacalcet
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Accession:CHEBI:48390 term browser browse the term
Definition:A secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group.
Synonyms:exact_synonym: N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
 related_synonym: (R)-alpha-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine;   CNC;   Formula=C22H22F3N;   InChI=1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1;   InChIKey=VDHAWDNDOKGFTD-MRXNPFEDSA-N;   Mimpara;   N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine;   SMILES=C[C@@H](NCCCc1cccc(c1)C(F)(F)F)c1cccc2ccccc12
 xref: CAS:226256-56-0;   DrugBank:DB01012;   Drug_Central:647;   KEGG:D03504;   LINCS:LSM-5815
 xref_mesh: MESH:D000069449
 xref: PMID:16680561;   PMID:17652181;   Patent:US2007060645;   Patent:US6011068;   Patent:US6211244;   Reaxys:10191346;   Wikipedia:Cinacalcet


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cinacalcet term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Cinacalcet results in decreased activity of CYP2D6 protein CTD PMID:16680561 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Cinacalcet results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Pth parathyroid hormone decreases expression
decreases secretion
multiple interactions
ISO Cinacalcet results in decreased expression of PTH protein
Cinacalcet results in decreased secretion of PTH protein
[Cinacalcet co-treated with Vitamin D] results in decreased expression of PTH protein
CTD PMID:17060004, PMID:18256372, PMID:21541686, PMID:22118402 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            calcimimetic 3
              cinacalcet 3
                cinacalcet carbamate 0
                cinacalcet hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17968
                                  halohydrocarbon 13938
                                    haloalkane 11658
                                      fluoroalkane 7109
                                        fluoromethanes 6329
                                          tetrafluoromethane 6329
                                            trifluoromethyl group 6329
                                              (trifluoromethyl)benzenes 6329
                                                cinacalcet 3
                                                  cinacalcet carbamate 0
                                                  cinacalcet hydrochloride 0
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