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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:protophilic solvent
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Accession:CHEBI:48359 term browser browse the term
Definition:Solvent that is capable of acting as a hydron (proton) acceptor.
Synonyms:related_synonym: HBA solvent;   hydrogen bond acceptor solvent


show annotations for term's descendants           Sort by:
arecoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FN1 fibronectin 1 multiple interactions
increases expression		 EXP pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of FN1 protein] CTD PMID:26908192 NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,014 		JBrowse link
G SERPINE1 serpin family E member 1 increases expression
multiple interactions		 EXP Arecoline results in increased expression of SERPINE1 protein
pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of SERPINE1 protein]		 CTD PMID:26908192 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
increases expression		 EXP Arecoline results in increased secretion of and results in increased activity of TGFB1 protein; pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of TGFB1 mRNA] CTD PMID:26908192 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046 		JBrowse link
aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions
increases hydrolysis		 EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510 		JBrowse link
cocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases expression
multiple interactions		 EXP Cocaine results in increased expression of EDN1 protein
1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]; Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]		 CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
diprotium oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP1 aquaporin 1 (Colton blood group) increases transport
multiple interactions		 EXP AQP1 protein results in increased transport of Water
Mercuric Chloride inhibits the reaction [AQP1 protein results in increased transport of Water]		 CTD PMID:16534851 NCBI chr18:42,063,482...42,076,741
Ensembl chr18:42,063,485...42,076,746 		JBrowse link
enalaprilat dihydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases activity EXP Enalaprilat results in decreased activity of AGT protein modified form CTD PMID:7890486 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G KNG1 kininogen 1 increases activity EXP Enalaprilat results in increased activity of KNG1 protein modified form CTD PMID:7890486 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958 		JBrowse link
eplerenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Eplerenone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
KT 5823 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL4A2 collagen type IV alpha 2 chain multiple interactions
decreases expression		 EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A2 protein]
KT 5823 results in decreased expression of COL4A2 protein		 CTD PMID:21307347 NCBI chr11:76,996,885...77,161,617
Ensembl chr11:76,997,516...77,161,614 		JBrowse link
G COL4A3 collagen type IV alpha 3 chain decreases expression
multiple interactions		 EXP KT 5823 results in decreased expression of COL4A3 mRNA
KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A3 mRNA]		 CTD PMID:21307347 NCBI chr15:128,611,640...128,763,331
Ensembl chr15:128,611,866...128,763,122 		JBrowse link
G ITGAV integrin subunit alpha V multiple interactions EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]] CTD PMID:21307347 NCBI chr15:91,604,666...91,711,843
Ensembl chr15:91,604,676...91,711,851 		JBrowse link
G ITGB3 integrin subunit beta 3 multiple interactions EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]] CTD PMID:21307347 NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,514...16,752,292 		JBrowse link
nifedipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A29 cytochrome P450 family 3 subfamily A member 29 multiple interactions
increases oxidation		 EXP Ketoconazole inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine]; Troleandomycin inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine] CTD PMID:20863320 NCBI chr 3:6,738,502...6,778,121
Ensembl chr 3:6,738,486...6,778,944 		JBrowse link
tacrolimus hydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity EXP Tacrolimus results in increased activity of CASP3 protein CTD PMID:14675044 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
water term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP1 aquaporin 1 (Colton blood group) increases transport
multiple interactions		 EXP AQP1 protein results in increased transport of Water
Mercuric Chloride inhibits the reaction [AQP1 protein results in increased transport of Water]		 CTD PMID:16534851 NCBI chr18:42,063,482...42,076,741
Ensembl chr18:42,063,485...42,076,746 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5164
    role 5131
      chemical role 870
        acceptor 312
          Bronsted base 311
            protophilic solvent 15
              amphiprotic solvent + 15
paths to the root