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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:protophilic solvent
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Accession:CHEBI:48359 term browser browse the term
Definition:Solvent that is capable of acting as a hydron (proton) acceptor.
Synonyms:related_synonym: HBA solvent;   hydrogen bond acceptor solvent


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amlodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases expression EXP Amlodipine results in increased expression of REN protein CTD PMID:10218729 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
cilazapril monohydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases expression EXP Cilazapril results in decreased expression of AGT protein CTD PMID:2419701 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G REN renin increases activity EXP Cilazapril results in increased activity of REN protein CTD PMID:2419701 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
eplerenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor multiple interactions EXP Eplerenone binds to and results in decreased activity of AR protein CTD PMID:23242577 NCBI chr24:34,713,390...34,731,461
NCBI chr  X:51,969,785...52,167,450
Ensembl chr  X:51,969,785...52,151,912 		JBrowse link
felodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Felodipine results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
vincristine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases export
affects response to substance
multiple interactions		 EXP ABCB1 protein results in increased export of Vincristine
ABCB1 protein affects the susceptibility to Vincristine
valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]		 CTD PMID:24975508 PMID:28093773 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 decreases response to substance EXP ABCC1 protein results in decreased susceptibility to Vincristine CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331 		JBrowse link
yohimbine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions EXP Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 494
    role 501
      chemical role 420
        acceptor 323
          Bronsted base 322
            protophilic solvent 8
              amphiprotic solvent + 8
paths to the root