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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:polar solvent
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Accession:CHEBI:48354 term browser browse the term
Definition:A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds.
Synonyms:related_synonym: polar solvents



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acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein] CTD PMID:20665602 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
G PLA2G1B phospholipase A2 group IB multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
acrolein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GOT1 glutamic-oxaloacetic transaminase 1 affects metabolic processing
decreases activity
affects folding
EXP Acrolein affects the metabolism of GOT1 protein
Acrolein results in decreased activity of GOT1 protein
Acrolein affects the folding of GOT1 protein
CTD PMID:12365456 NCBI chr14:110,608,422...110,635,825
Ensembl chr14:110,608,430...110,635,874
JBrowse link
alachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C49 cytochrome P450 2C49 decreases response to substance EXP CYP2C49 protein results in decreased susceptibility to alachlor CTD PMID:16315095 NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455
JBrowse link
aldosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions
increases secretion
EXP 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer inhibits the reaction [AGT protein results in increased secretion of Aldosterone]; Enkephalin, D-Penicillamine (2,5)- inhibits the reaction [AGT protein results in increased secretion of Aldosterone] CTD PMID:22100847 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP Aldosterone results in increased expression of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,508...104,384,547
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression EXP Aldosterone results in increased expression of GCLC protein CTD PMID:24512358 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP Aldosterone results in increased expression of HMOX1 protein CTD PMID:24512358
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; acetovanillone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Aldosterone results in increased expression of and results in increased activity of NFE2L2 protein; diphenyleneiodonium inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Eplerenone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Ro 32-0432 inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; tempol inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; W 7 inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
JBrowse link
G SOD1 superoxide dismutase 1 increases expression EXP Aldosterone results in increased expression of SOD1 protein CTD PMID:24512358 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP Aldosterone results in increased expression of TXNRD1 protein CTD PMID:24512358 NCBI chr 5:80,170,334...80,213,889
Ensembl chr 5:80,172,260...80,236,219
JBrowse link
arecoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FN1 fibronectin 1 multiple interactions
increases expression
EXP pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of FN1 protein] CTD PMID:26908192 NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,014
JBrowse link
G SERPINE1 serpin family E member 1 increases expression
multiple interactions
EXP Arecoline results in increased expression of SERPINE1 protein
pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of SERPINE1 protein]
CTD PMID:26908192 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
increases expression
EXP Arecoline results in increased secretion of and results in increased activity of TGFB1 protein; pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of TGFB1 mRNA] CTD PMID:26908192 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046
JBrowse link
aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions
increases hydrolysis
EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 increases activity EXP benazepril results in increased activity of KNG1 protein modified form CTD PMID:7890486 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958
JBrowse link
clofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO1 aconitase 1 increases expression EXP Clofibrate results in increased expression of ACO1 mRNA CTD PMID:17363680 NCBI chr10:33,937,833...34,001,895
Ensembl chr10:33,937,833...34,001,900
JBrowse link
G ACOX1 acyl-CoA oxidase 1 increases expression EXP Clofibrate results in increased expression of ACOX1 mRNA CTD PMID:16896063 PMID:17437637 NCBI chr12:5,450,913...5,479,550
Ensembl chr12:5,439,361...5,479,546
JBrowse link
G AGT angiotensinogen multiple interactions EXP Clofibrate inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein] CTD PMID:17105827 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
JBrowse link
G ALB albumin decreases expression EXP Clofibrate results in decreased expression of ALB mRNA CTD PMID:16896063 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Clofibrate results in increased expression of BAX mRNA CTD PMID:17437637 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP Clofibrate results in decreased expression of BCL2L1 mRNA CTD PMID:17437637 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694
JBrowse link
G CAT catalase increases expression EXP Clofibrate results in increased expression of CAT mRNA CTD PMID:17437637 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression EXP Clofibrate results in increased expression of CPT1A mRNA CTD PMID:16896063 PMID:17363680 NCBI chr 2:4,250,642...4,293,914
Ensembl chr 2:4,233,099...4,293,911
JBrowse link
G CTSB cathepsin B increases expression EXP Clofibrate results in increased expression of CTSB mRNA CTD PMID:16896063 NCBI chr14:15,014,139...15,035,081
Ensembl chr14:15,011,711...15,033,877
JBrowse link
G DIO2 iodothyronine deiodinase 2 decreases expression EXP Clofibrate results in decreased expression of DIO2 mRNA CTD PMID:16896063 NCBI chr 7:103,096,414...103,110,749
Ensembl chr 7:103,096,433...103,323,258
JBrowse link
G EDN1 endothelin 1 decreases expression
multiple interactions
EXP Clofibrate results in decreased expression of EDN1 protein
Clofibrate inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]; Clofibrate inhibits the reaction [KNG1 protein modified form results in increased expression of EDN1 protein]; Clofibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EDN1 protein]; Nitric Oxide deficiency inhibits the reaction [Clofibrate results in decreased expression of EDN1 protein]
CTD PMID:17105827 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G FABP1 fatty acid binding protein 1 increases expression EXP Clofibrate results in increased expression of FABP1 mRNA CTD PMID:17363680 NCBI chr 3:57,850,511...57,854,966
Ensembl chr 3:57,850,499...57,854,956
JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression EXP Clofibrate results in decreased expression of GPX1 mRNA CTD PMID:17437637 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression EXP Clofibrate results in increased expression of HMGCS2 mRNA CTD PMID:17363680 NCBI chr 4:101,420,941...101,440,302
Ensembl chr 4:101,420,872...101,438,126
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Clofibrate results in increased expression of JUN mRNA CTD PMID:17437637 NCBI chr 6:153,686,425...153,687,635
Ensembl chr 6:153,685,682...153,687,636
JBrowse link
G KNG1 kininogen 1 multiple interactions EXP Clofibrate inhibits the reaction [KNG1 protein modified form results in increased expression of EDN1 protein] CTD PMID:17105827 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression EXP Clofibrate results in increased expression of MYC mRNA CTD PMID:17437637 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078
JBrowse link
G NOS3 nitric oxide synthase 3 increases expression
multiple interactions
EXP Clofibrate results in increased expression of NOS3 protein
calphostin C inhibits the reaction [Clofibrate results in increased expression of NOS3 protein]
CTD PMID:17105827 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha increases expression
multiple interactions
EXP Clofibrate results in increased expression of PPARA; Clofibrate results in increased expression of PPARA protein
calphostin C inhibits the reaction [Clofibrate results in increased expression of PPARA protein]; calphostin C inhibits the reaction [Clofibrate results in increased expression of PPARA]; Tetradecanoylphorbol Acetate inhibits the reaction [Clofibrate results in increased expression of PPARA]
CTD PMID:17105827 PMID:20568414 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239
JBrowse link
G SCD stearoyl-CoA desaturase increases expression EXP Clofibrate results in increased expression of SCD mRNA CTD PMID:17363680 NCBI chr14:111,461,560...111,478,033
Ensembl chr14:111,461,569...111,478,020
JBrowse link
G SLC5A5 solute carrier family 5 member 5 increases expression EXP Clofibrate results in increased expression of SLC5A5 mRNA CTD PMID:16896063 NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,155...59,885,266
JBrowse link
G SOD1 superoxide dismutase 1 increases expression EXP Clofibrate results in increased expression of SOD1 mRNA CTD PMID:17437637 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
JBrowse link
G THRA thyroid hormone receptor alpha decreases expression EXP Clofibrate results in decreased expression of THRA mRNA CTD PMID:16896063 NCBI chr12:22,270,506...22,296,684
Ensembl chr12:22,270,062...22,296,618
JBrowse link
G TNF tumor necrosis factor decreases expression EXP Clofibrate results in decreased expression of TNF mRNA CTD PMID:17437637 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
G TPO thyroid peroxidase increases expression EXP Clofibrate results in increased expression of TPO mRNA CTD PMID:16896063 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208
JBrowse link
G TSHR thyroid stimulating hormone receptor increases expression EXP Clofibrate results in increased expression of TSHR mRNA CTD PMID:16896063 NCBI chr 7:103,768,260...103,925,777
Ensembl chr 7:103,768,296...103,925,922
JBrowse link
G TTR transthyretin decreases expression EXP Clofibrate results in decreased expression of TTR mRNA CTD PMID:16896063 NCBI chr 6:115,496,338...115,503,974
Ensembl chr 6:115,496,326...115,503,977
JBrowse link
cocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases expression
multiple interactions
EXP Cocaine results in increased expression of EDN1 protein
1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]; Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]
CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
diethyl maleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRDX2 peroxiredoxin 2 decreases activity EXP diethyl maleate results in decreased activity of PRDX2 protein CTD PMID:19208552 NCBI chr 2:66,207,829...66,211,474
Ensembl chr 2:66,207,828...66,212,009
JBrowse link
diprotium oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP1 aquaporin 1 (Colton blood group) increases transport
multiple interactions
EXP AQP1 protein results in increased transport of Water
Mercuric Chloride inhibits the reaction [AQP1 protein results in increased transport of Water]
CTD PMID:16534851 NCBI chr18:42,063,482...42,076,741
Ensembl chr18:42,063,485...42,076,746
JBrowse link
enalaprilat dihydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases activity EXP Enalaprilat results in decreased activity of AGT protein modified form CTD PMID:7890486 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
JBrowse link
G KNG1 kininogen 1 increases activity EXP Enalaprilat results in increased activity of KNG1 protein modified form CTD PMID:7890486 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958
JBrowse link
eplerenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Eplerenone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
JBrowse link
ethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACADL acyl-CoA dehydrogenase long chain increases expression EXP Ethanol results in increased expression of ACADL mRNA CTD PMID:28069986 NCBI chr15:112,935,631...112,969,381
Ensembl chr15:112,933,506...112,969,577
JBrowse link
G ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif 8 increases expression EXP Ethanol results in increased expression of ADAMTS8 mRNA CTD PMID:28069986 NCBI chr 9:57,090,313...57,113,077
Ensembl chr 9:57,090,617...57,110,414
JBrowse link
G AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 decreases expression EXP Ethanol results in decreased expression of AGPAT1 mRNA CTD PMID:28069986 NCBI chr 7:24,205,930...24,208,430
Ensembl chr 7:24,204,905...24,213,193
JBrowse link
G AGPS alkylglycerone phosphate synthase decreases expression EXP Ethanol results in decreased expression of AGPS mRNA CTD PMID:28069986 NCBI chr15:83,146,063...83,285,905
Ensembl chr15:83,146,002...83,391,984
JBrowse link
G ALDH9A1 aldehyde dehydrogenase 9 family member A1 increases expression EXP Ethanol results in increased expression of ALDH9A1 mRNA CTD PMID:28069986 NCBI chr 4:85,029,914...85,057,650 JBrowse link
G ALOX5 arachidonate 5-lipoxygenase increases expression EXP Ethanol results in increased expression of ALOX5 mRNA CTD PMID:28069986 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,016...90,907,094
JBrowse link
G ANXA8 annexin A8 increases expression EXP Ethanol results in increased expression of ANXA8 mRNA CTD PMID:28069986 NCBI chr14:88,319,209...88,340,716 JBrowse link
G APP amyloid beta precursor protein increases expression EXP Ethanol results in increased expression of APP mRNA CTD PMID:28069986 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,435,094...189,716,056
JBrowse link
G ARSK arylsulfatase family member K increases expression EXP Ethanol results in increased expression of ARSK mRNA CTD PMID:28069986 NCBI chr 2:102,164,089...102,210,293
Ensembl chr 2:102,164,222...102,212,780
JBrowse link
G ATP6V0D2 ATPase H+ transporting V0 subunit d2 increases expression EXP Ethanol results in increased expression of ATP6V0D2 mRNA CTD PMID:28069986 NCBI chr 4:50,694,188...50,749,373
Ensembl chr 4:50,694,189...50,749,378
JBrowse link
G C5H12orf57 chromosome 5 C12orf57 homolog increases expression EXP Ethanol results in increased expression of C12ORF57 mRNA CTD PMID:28069986 NCBI chr 5:63,779,510...63,781,307
Ensembl chr 5:63,779,513...63,781,517
JBrowse link
G CBS cystathionine beta-synthase multiple interactions EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of CBS protein CTD PMID:16792574 NCBI chr13:206,205,942...206,231,363
Ensembl chr13:206,205,946...206,230,248
JBrowse link
G CCNB1IP1 cyclin B1 interacting protein 1 decreases expression EXP Ethanol results in decreased expression of CCNB1IP1 mRNA CTD PMID:28069986 NCBI chr 7:78,553,680...78,576,057
Ensembl chr 7:78,564,122...78,575,462
JBrowse link
G CD109 CD109 molecule increases expression EXP Ethanol results in increased expression of CD109 mRNA CTD PMID:28069986 NCBI chr 1:92,081,675...92,241,079
Ensembl chr 1:92,054,821...92,286,730
JBrowse link
G CD47 CD47 molecule increases expression EXP Ethanol results in increased expression of CD47 mRNA CTD PMID:28069986 NCBI chr13:151,427,933...151,488,064
Ensembl chr13:151,429,288...151,488,544
JBrowse link
G CLDN4 claudin 4 decreases expression EXP Ethanol results in decreased expression of CLDN4 mRNA CTD PMID:28069986 NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925
JBrowse link
G CLU clusterin increases expression EXP Ethanol results in increased expression of CLU mRNA CTD PMID:28069986 NCBI chr14:11,336,585...11,352,569
Ensembl chr14:11,336,595...11,349,764
JBrowse link
G CTH cystathionine gamma-lyase increases activity
multiple interactions
EXP Ethanol results in increased activity of CTH protein
[Ethanol co-treated with Folic Acid deficiency] results in increased activity of CTH protein
CTD PMID:16792574 NCBI chr 6:142,454,922...142,486,352
Ensembl chr 6:142,454,914...142,486,367
JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 increases expression EXP Ethanol results in increased expression of CYP51 mRNA CTD PMID:28069986 NCBI chr 9:72,057,506...72,079,587
Ensembl chr 9:72,057,511...72,079,444
JBrowse link
G EEF2 eukaryotic translation elongation factor 2 decreases expression EXP Ethanol results in decreased expression of EEF2 mRNA CTD PMID:28069986 NCBI chr 2:74,746,541...74,756,687
Ensembl chr 2:74,747,080...74,756,680
JBrowse link
G EIF3L eukaryotic translation initiation factor 3 subunit L decreases expression EXP Ethanol results in decreased expression of EIF3L mRNA CTD PMID:28069986 NCBI chr 5:9,970,013...9,996,086
Ensembl chr 5:9,968,428...10,000,092
JBrowse link
G FBLN2 fibulin 2 increases expression EXP Ethanol results in increased expression of FBLN2 mRNA CTD PMID:28069986 NCBI chr13:70,757,255...70,830,430
Ensembl chr13:70,757,265...70,830,388
JBrowse link
G FKBP1A FKBP prolyl isomerase 1A decreases expression EXP Ethanol results in decreased expression of FKBP1A mRNA CTD PMID:28069986 NCBI chr17:33,910,047...33,935,212 JBrowse link
G FUCA1 alpha-L-fucosidase 1 increases expression EXP Ethanol results in increased expression of FUCA1 mRNA CTD PMID:28069986 NCBI chr 6:81,638,213...81,655,993
Ensembl chr 6:81,637,994...81,656,068
JBrowse link
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 increases expression EXP Ethanol results in increased expression of GABRB3 mRNA CTD PMID:28069986 NCBI chr 1:140,566,443...140,906,516
Ensembl chr 1:140,566,540...140,905,623
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
increases activity
multiple interactions
EXP Ethanol results in increased expression of GCLC mRNA
Ethanol results in increased activity of GCLC protein
[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GCLC protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GCLC mRNA
CTD PMID:16792574 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530
JBrowse link
G GPX6 glutathione peroxidase 6 increases expression EXP Ethanol results in increased expression of GPX6 mRNA CTD PMID:28069986 NCBI chr 7:22,256,013...22,267,992
Ensembl chr 7:22,256,038...22,267,992
JBrowse link
G GRTP1 growth hormone regulated TBC protein 1 decreases expression EXP Ethanol results in decreased expression of GRTP1 mRNA CTD PMID:28069986 NCBI chr11:78,618,720...78,637,502
Ensembl chr11:78,618,713...78,637,478
JBrowse link
G GSR glutathione-disulfide reductase increases activity
increases expression
multiple interactions
EXP Ethanol results in increased activity of GSR protein
Ethanol results in increased expression of GSR mRNA
[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSR protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSR mRNA
CTD PMID:16792574 NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984
JBrowse link
G GSS glutathione synthetase increases expression
increases activity
multiple interactions
EXP Ethanol results in increased expression of GSS mRNA
Ethanol results in increased activity of GSS protein
[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSS protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSS mRNA
CTD PMID:16792574 NCBI chr17:38,316,199...38,342,253
Ensembl chr17:38,312,720...38,342,298
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 increases expression EXP Ethanol results in increased expression of HSD17B1 mRNA CTD PMID:28069986 NCBI chr12:20,269,468...20,271,349
Ensembl chr12:20,269,056...20,271,548
JBrowse link
G HSD17B14 hydroxysteroid 17-beta dehydrogenase 14 decreases expression EXP Ethanol results in decreased expression of HSD17B14 mRNA CTD PMID:28069986 NCBI chr 6:54,125,229...54,144,143 JBrowse link
G HTRA1 HtrA serine peptidase 1 increases expression EXP Ethanol results in increased expression of HTRA1 mRNA CTD PMID:28069986 NCBI chr14:132,043,044...132,103,590
Ensembl chr14:132,041,934...132,103,595
JBrowse link
G ITIH5 inter-alpha-trypsin inhibitor heavy chain 5 increases expression EXP Ethanol results in increased expression of ITIH5 mRNA CTD PMID:28069986 NCBI chr10:63,688,416...63,764,566
Ensembl chr10:63,688,427...63,767,118
JBrowse link
G KIAA1217 KIAA1217 increases expression EXP Ethanol results in increased expression of KIAA1217 mRNA CTD PMID:28069986 NCBI chr10:50,706,713...51,032,010
Ensembl chr10:50,707,054...51,205,619
JBrowse link
G KRT6A keratin 6A increases expression EXP Ethanol results in increased expression of KRT6A mRNA CTD PMID:28069986 NCBI chr 5:17,830,147...17,851,113
Ensembl chr 5:17,780,928...17,868,402
JBrowse link
G LOC100513346 mitochondrial import inner membrane translocase subunit TIM16 decreases expression EXP Ethanol results in decreased expression of PAM16 mRNA CTD PMID:28069986 NCBI chr 3:37,928,098...38,005,619
Ensembl chr 3:37,928,096...37,985,151
JBrowse link
G LOC100526118 glutathione S-transferase A1-like multiple interactions
increases expression
EXP [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSTA1 mRNA
Ethanol results in increased expression of GSTA1 mRNA
CTD PMID:16792574 NCBI chr 7:46,571,106...46,588,139 JBrowse link
G MAP1S microtubule associated protein 1S decreases expression EXP Ethanol results in decreased expression of MAP1S mRNA CTD PMID:28069986 NCBI chr 2:60,003,116...60,043,133
Ensembl chr 2:59,999,168...60,029,865
JBrowse link
G MIOX myo-inositol oxygenase decreases expression EXP Ethanol results in decreased expression of MIOX mRNA CTD PMID:28069986 NCBI chr 5:249,312...251,547
Ensembl chr 5:248,235...251,553
JBrowse link
G MKNK2 MAPK interacting serine/threonine kinase 2 decreases expression EXP Ethanol results in decreased expression of MKNK2 mRNA CTD PMID:28069986 NCBI chr 2:76,510,302...76,522,885
Ensembl chr 2:76,510,303...76,522,883
JBrowse link
G NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 increases expression EXP Ethanol results in increased expression of NAALAD2 mRNA CTD PMID:28069986 NCBI chr 9:23,106,795...23,161,825
Ensembl chr 9:23,111,059...23,161,832
JBrowse link
G PLEKHO1 pleckstrin homology domain containing O1 increases expression EXP Ethanol results in increased expression of PLEKHO1 mRNA CTD PMID:28069986 NCBI chr 4:98,924,115...98,934,610
Ensembl chr 4:98,923,996...98,934,189
JBrowse link
G PRKD3 protein kinase D3 increases expression EXP Ethanol results in increased expression of PRKD3 mRNA CTD PMID:28069986 NCBI chr 3:102,840,666...102,949,128
Ensembl chr 3:102,842,229...102,941,329
JBrowse link
G PRNP prion protein increases expression EXP Ethanol results in increased expression of PRNP mRNA CTD PMID:28069986 NCBI chr17:13,694,195...13,705,126
Ensembl chr17:13,694,190...13,705,124
JBrowse link
G RPL13A ribosomal protein L13a decreases expression EXP Ethanol results in decreased expression of RPL13A mRNA CTD PMID:28069986 NCBI chr 6:54,551,772...54,568,752
Ensembl chr 6:54,551,533...54,561,489
JBrowse link
G SAFB scaffold attachment factor B increases expression EXP Ethanol results in increased expression of SAFB mRNA CTD PMID:28069986 NCBI chr 2:73,300,624...73,334,494
Ensembl chr 2:73,300,632...73,334,494
JBrowse link
G SLC7A4 solute carrier family 7 member 4 decreases expression EXP Ethanol results in decreased expression of SLC7A4 mRNA CTD PMID:28069986 NCBI chr14:50,631,693...50,638,381
Ensembl chr14:50,633,878...50,637,404
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions
decreases activity
EXP [Ethanol co-treated with Folic Acid deficiency] results in decreased activity of SOD1 protein
Ethanol results in decreased activity of SOD1 protein
CTD PMID:16792574 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
increases activity
EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of SOD2 protein
Ethanol results in increased activity of SOD2 protein
CTD PMID:16792574 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link
G SRGN serglycin increases expression EXP Ethanol results in increased expression of SRGN mRNA CTD PMID:28069986 NCBI chr14:72,183,368...72,199,262
Ensembl chr14:72,183,363...72,199,250
JBrowse link
G STXBP2 syntaxin binding protein 2 decreases expression EXP Ethanol results in decreased expression of STXBP2 mRNA CTD PMID:28069986 NCBI chr 2:71,504,575...71,513,446
Ensembl chr 2:71,504,569...71,513,422
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 increases expression EXP Ethanol results in increased expression of TIMP2 mRNA CTD PMID:28069986 NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,835
JBrowse link
G TMEM98 transmembrane protein 98 increases expression EXP Ethanol results in increased expression of TMEM98 mRNA CTD PMID:28069986 NCBI chr12:42,087,691...42,101,152
Ensembl chr12:42,083,553...42,100,494
JBrowse link
G TNNI3 troponin I3, cardiac type decreases expression EXP Ethanol results in decreased expression of TNNI3 mRNA CTD PMID:28069986 NCBI chr 6:59,366,828...59,377,490
Ensembl chr 6:59,371,080...59,377,734
Ensembl chr 6:59,371,080...59,377,734
JBrowse link
G TRAPPC5 trafficking protein particle complex subunit 5 decreases expression EXP Ethanol results in decreased expression of TRAPPC5 mRNA CTD PMID:28069986 NCBI chr 2:71,470,441...71,472,614
Ensembl chr 2:71,470,445...71,472,549
JBrowse link
G TRPT1 tRNA phosphotransferase 1 decreases expression EXP Ethanol results in decreased expression of TRPT1 mRNA CTD PMID:28069986 NCBI chr 2:7,876,028...7,887,589
Ensembl chr 2:7,883,945...7,888,133
JBrowse link
G WFDC1 WAP four-disulfide core domain 1 increases expression EXP Ethanol results in increased expression of WFDC1 mRNA CTD PMID:28069986 NCBI chr 6:4,333,729...4,365,122
Ensembl chr 6:4,333,731...4,399,237
JBrowse link
G WNT5B Wnt family member 5B increases expression EXP Ethanol results in increased expression of WNT5B mRNA CTD PMID:28069986 NCBI chr 5:68,627,158...68,731,938
Ensembl chr 5:68,627,185...68,732,265
JBrowse link
fenofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 affects localization EXP Fenofibrate affects the localization of ABCA1 protein CTD PMID:16530456 NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492
JBrowse link
G APOA1 apolipoprotein A1 increases secretion
decreases expression
multiple interactions
EXP Fenofibrate results in increased secretion of APOA1 protein
Fenofibrate results in decreased expression of APOA1 mRNA
Fenofibrate inhibits the reaction [APOA1 protein results in increased transport of Cholesterol]; Fenofibrate promotes the reaction [APOA1 protein results in increased transport of Cholesterol]
CTD PMID:16530456 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713
JBrowse link
G SCARB1 scavenger receptor class B member 1 affects localization EXP Fenofibrate affects the localization of SCARB1 protein CTD PMID:16530456 NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,568
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [Fenofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein] CTD PMID:15226458 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link
formic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP4A ATPase H+/K+ transporting subunit alpha decreases expression EXP formic acid results in decreased expression of ATP4A mRNA CTD PMID:16614409 NCBI chr 6:44,984,014...45,057,796
Ensembl chr 6:44,984,233...44,997,552
JBrowse link
indometacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen affects activity EXP Indomethacin affects the activity of AGT protein CTD PMID:21127344 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Indomethacin results in increased expression of DDIT3 mRNA CTD PMID:18799549 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Indomethacin results in increased expression of HSPA5 mRNA CTD PMID:18799549 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
KT 5823 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL4A2 collagen type IV alpha 2 chain multiple interactions
decreases expression
EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A2 protein]
KT 5823 results in decreased expression of COL4A2 protein
CTD PMID:21307347 NCBI chr11:76,996,885...77,161,617
Ensembl chr11:76,997,516...77,161,614
JBrowse link
G COL4A3 collagen type IV alpha 3 chain decreases expression
multiple interactions
EXP KT 5823 results in decreased expression of COL4A3 mRNA
KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A3 mRNA]
CTD PMID:21307347 NCBI chr15:128,611,640...128,763,331
Ensembl chr15:128,611,866...128,763,122
JBrowse link
G ITGAV integrin subunit alpha V multiple interactions EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]] CTD PMID:21307347 NCBI chr15:91,604,666...91,711,843
Ensembl chr15:91,604,676...91,711,851
JBrowse link
G ITGB3 integrin subunit beta 3 multiple interactions EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]] CTD PMID:21307347 NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,514...16,752,292
JBrowse link
malathion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT2 AKT serine/threonine kinase 2 increases expression EXP Malathion results in increased expression of AKT2 mRNA CTD PMID:31535366 NCBI chr 6:48,555,785...48,620,472
Ensembl chr 6:48,555,795...48,587,919
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Malathion results in increased expression of BAX mRNA CTD PMID:31535366 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G CAT catalase decreases expression
multiple interactions
EXP Malathion results in decreased expression of CAT mRNA
Melatonin inhibits the reaction [Malathion results in decreased expression of CAT mRNA]
CTD PMID:31535366 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases expression EXP Malathion results in decreased expression of CYP1A1 mRNA CTD PMID:31535366 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases expression EXP Malathion results in decreased expression of CYP1B1 mRNA CTD PMID:31535366 NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,205,683
JBrowse link
G DUOX2 dual oxidase 2 decreases expression EXP Malathion results in decreased expression of DUOX2 mRNA CTD PMID:31535366 NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406
JBrowse link
G GPX4 glutathione peroxidase 4 increases expression EXP Malathion results in increased expression of GPX4 mRNA CTD PMID:31535366 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931
JBrowse link
G GPX6 glutathione peroxidase 6 increases expression EXP Malathion results in increased expression of GPX6 mRNA CTD PMID:31535366 NCBI chr 7:22,256,013...22,267,992
Ensembl chr 7:22,256,038...22,267,992
JBrowse link
G KDSR 3-ketodihydrosphingosine reductase decreases expression
multiple interactions
EXP Malathion results in decreased expression of BCL2 mRNA
Melatonin inhibits the reaction [Malathion results in decreased expression of BCL2 mRNA]
CTD PMID:31535366 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
JBrowse link
G LOC100526118 glutathione S-transferase A1-like decreases expression EXP Malathion results in decreased expression of GSTA1 mRNA CTD PMID:31535366 NCBI chr 7:46,571,106...46,588,139 JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I affects expression EXP Malathion affects the expression of COX1 mRNA CTD PMID:17454254 NCBI chr MT:6,511...8,055
Ensembl chr MT:6,511...8,055
JBrowse link
G MT-CO3 mitochondrially encoded cytochrome c oxidase III affects expression EXP Malathion affects the expression of COX3 mRNA CTD PMID:17454254 NCBI chr MT:9,800...10,583
Ensembl chr MT:9,800...10,583
JBrowse link
G PLIN2 perilipin 2 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 protein]
Malathion results in decreased expression of PLIN2 mRNA; Malathion results in decreased expression of PLIN2 protein
CTD PMID:31535366 NCBI chr 1:203,683,867...203,709,277
Ensembl chr 1:203,683,862...203,709,273
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG protein]
Malathion results in decreased expression of PPARG mRNA; Malathion results in decreased expression of PPARG protein
CTD PMID:31535366 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944
JBrowse link
G SLC34A2 solute carrier family 34 member 2 increases expression EXP Malathion results in increased expression of SLC34A2 mRNA CTD PMID:31535366 NCBI chr 8:19,481,127...19,507,903
Ensembl chr 8:19,481,198...19,509,666
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Malathion results in increased expression of SOD2 mRNA CTD PMID:31535366 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link
G SORD sorbitol dehydrogenase increases expression EXP Malathion results in increased expression of SORD mRNA CTD PMID:31535366 NCBI chr 1:126,659,198...126,701,084
Ensembl chr 1:126,655,156...126,701,138
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
EXP Malathion results in increased expression of TP53 mRNA
Melatonin inhibits the reaction [Malathion results in increased expression of TP53 mRNA]
CTD PMID:31535366 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
JBrowse link
malonaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions EXP CAT protein inhibits the reaction [4-xylene results in increased secretion of Malondialdehyde]; CAT protein inhibits the reaction [Toluene results in increased secretion of Malondialdehyde] CTD PMID:12781212 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
methoprene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GPD1 glycerol-3-phosphate dehydrogenase 1 increases activity EXP Methoprene results in increased activity of GPD1 protein CTD PMID:15583048 NCBI chr 5:16,008,179...16,021,676
Ensembl chr 5:16,007,448...16,017,825
JBrowse link
methylglyoxal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GOT1 glutamic-oxaloacetic transaminase 1 affects glycation
affects folding
decreases activity
EXP Pyruvaldehyde affects the glycation of GOT1 protein
Pyruvaldehyde affects the folding of GOT1 protein
Pyruvaldehyde results in decreased activity of GOT1 protein
CTD PMID:12559987 NCBI chr14:110,608,422...110,635,825
Ensembl chr14:110,608,430...110,635,874
JBrowse link
N-acetyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of BAX protein] CTD PMID:19135140 PMID:33905761 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G BMP15 bone morphogenetic protein 15 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of BMP15 mRNA] CTD PMID:26386189 NCBI chr  X:44,613,122...44,620,575
Ensembl chr  X:44,613,122...44,620,575
JBrowse link
G CASP3 caspase 3 multiple interactions EXP [Acetylcysteine co-treated with Zearalenone] results in decreased expression of CASP3 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]] CTD PMID:17383151 PMID:19135140 PMID:29109043 PMID:33905761 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G CASP9 caspase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP9 protein] CTD PMID:19135140 PMID:33905761 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP Acetylcysteine inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA] CTD PMID:19265715 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA]] CTD PMID:29109043 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA] CTD PMID:18086661 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA] CTD PMID:18086661 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions EXP Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]] CTD PMID:29109043 NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSP90B1 mRNA] CTD PMID:18086661 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA] CTD PMID:18086661 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
G KDSR 3-ketodihydrosphingosine reductase multiple interactions EXP [Acetylcysteine co-treated with fumonisin B1 co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]] CTD PMID:19135140 PMID:29109043 PMID:33905761 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:17383151 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:17383151 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of MYC] CTD PMID:12712633 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Acetylcysteine inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
JBrowse link
G PTX3 pentraxin 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of PTX3 mRNA] CTD PMID:26386189 NCBI chr13:97,273,594...97,279,570
Ensembl chr13:97,273,594...97,279,569
JBrowse link
G TNFAIP6 TNF alpha induced protein 6 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of TNFAIP6 mRNA] CTD PMID:26386189 NCBI chr15:862,013...881,352
Ensembl chr15:862,015...881,461
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]]; Acetylcysteine promotes the reaction [deoxynivalenol inhibits the reaction [Zearalenone results in increased expression of TP53 mRNA]] CTD PMID:29109043 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
JBrowse link
G ZP3 zona pellucida glycoprotein 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of ZP3 mRNA] CTD PMID:26386189 NCBI chr 3:9,934,760...9,944,924
Ensembl chr 3:9,934,761...9,944,941
JBrowse link
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 increases expression
multiple interactions
EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKT1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of AKT1 protein]
CTD PMID:16239170
G CLIC5 chloride intracellular channel 5 multiple interactions EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein] CTD PMID:20576581 NCBI chr 7:40,683,044...40,808,017
Ensembl chr 7:40,682,907...40,863,886
JBrowse link
G LRP2 LDL receptor related protein 2 multiple interactions EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of LRP2 protein] CTD PMID:20576581 NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,303...75,716,694
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
increases expression
EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of NOS3 protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NOS3 protein
CTD PMID:16239170 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
nifedipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A29 cytochrome P450 family 3 subfamily A member 29 multiple interactions
increases oxidation
EXP Ketoconazole inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine]; Troleandomycin inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine] CTD PMID:20863320 NCBI chr 3:6,738,502...6,778,121
Ensembl chr 3:6,738,486...6,778,944
JBrowse link
nitroglycerin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKG1 protein kinase cGMP-dependent 1 multiple interactions
increases activity
affects expression
EXP Superoxides affects the reaction [Nitroglycerin results in increased activity of PRKG1 protein]
Nitroglycerin affects the expression of PRKG1 mRNA; Nitroglycerin affects the expression of PRKG1 protein
CTD PMID:18037907 NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,558,533...98,793,010
JBrowse link
O-acetyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A5 solute carrier family 22 member 5 increases uptake EXP SLC22A5 protein results in increased uptake of Acetylcarnitine CTD PMID:16826461 NCBI chr 2:134,660,741...134,847,575
Ensembl chr 2:134,660,808...134,686,219
JBrowse link
phorbol 13-acetate 12-myristate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of CXCL8 protein CTD PMID:15912099 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G EDN1 endothelin 1 multiple interactions
increases expression
EXP Clofibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EDN1 protein] CTD PMID:17105827 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein CTD PMID:11325585 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein CTD PMID:11325585 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation EXP Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein CTD PMID:11325585 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
EXP Tetradecanoylphorbol Acetate results in decreased expression of PPARA; Tetradecanoylphorbol Acetate results in decreased expression of PPARA protein
calphostin C promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of PPARA]; Tetradecanoylphorbol Acetate inhibits the reaction [Clofibrate results in increased expression of PPARA]
CTD PMID:17105827 PMID:20568414 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239
JBrowse link
G PRKCB protein kinase C beta decreases phosphorylation EXP Tetradecanoylphorbol Acetate results in decreased phosphorylation of PRKCB protein CTD PMID:15089098 NCBI chr 3:21,995,227...22,383,628
Ensembl chr 3:21,995,231...22,383,264
JBrowse link
G PRKCD protein kinase C delta increases phosphorylation EXP Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCD protein CTD PMID:15089098 NCBI chr13:35,290,835...35,323,245
Ensembl chr13:35,290,610...35,323,356
JBrowse link
G SELE selectin E increases expression EXP Tetradecanoylphorbol Acetate results in increased expression of SELE protein CTD PMID:16797888 NCBI chr 4:81,289,061...81,299,657 JBrowse link
G SELP selectin P increases expression EXP Tetradecanoylphorbol Acetate results in increased expression of SELP protein CTD PMID:16797888 NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,399,955
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 increases expression EXP Tetradecanoylphorbol Acetate results in increased expression of VCAM1 protein CTD PMID:16797888 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222
JBrowse link
salubrinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2A eukaryotic translation initiation factor 2A increases phosphorylation EXP salubrinal results in increased phosphorylation of EIF2A protein CTD PMID:17464326 NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,274
JBrowse link
sulindac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLA2G1B phospholipase A2 group IB multiple interactions EXP Sulindac promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Sulindac promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
JBrowse link
T-2 toxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 increases expression EXP T-2 Toxin results in increased expression of ATF4 protein CTD PMID:34637808 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
EXP 4-phenylbutyric acid inhibits the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form] CTD PMID:34637808 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP T-2 Toxin results in increased expression of DDIT3 protein CTD PMID:34637808 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation EXP T-2 Toxin results in increased phosphorylation of EIF2AK3 protein CTD PMID:34637808 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP T-2 Toxin results in increased phosphorylation of EIF2S1 protein CTD PMID:34637808 NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 decreases expression EXP T-2 Toxin results in decreased expression of HSPA5 protein CTD PMID:34637808 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
tacrolimus hydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity EXP Tacrolimus results in increased activity of CASP3 protein CTD PMID:14675044 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
troleandomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A29 cytochrome P450 family 3 subfamily A member 29 multiple interactions EXP Troleandomycin inhibits the reaction [CYP3A29 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Troleandomycin inhibits the reaction [CYP3A29 protein results in increased hydroxylation of Testosterone]; Troleandomycin inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine] CTD PMID:20863320 NCBI chr 3:6,738,502...6,778,121
Ensembl chr 3:6,738,486...6,778,944
JBrowse link
tylosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP Tylosin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Tylosin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730
JBrowse link
water term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP1 aquaporin 1 (Colton blood group) increases transport
multiple interactions
EXP AQP1 protein results in increased transport of Water
Mercuric Chloride inhibits the reaction [AQP1 protein results in increased transport of Water]
CTD PMID:16534851 NCBI chr18:42,063,482...42,076,741
Ensembl chr18:42,063,485...42,076,746
JBrowse link
wortmannin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein] CTD PMID:16239170
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP Wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions EXP Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of NOS3 protein] CTD PMID:16239170 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
G RPS6 ribosomal protein S6 decreases phosphorylation
multiple interactions
EXP Wortmannin results in decreased phosphorylation of RPS6 protein
Wortmannin promotes the reaction [Ivermectin results in decreased phosphorylation of RPS6 protein]
CTD PMID:31400776 NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Wortmannin inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 1208
    role 1151
      chemical role 770
        solvent 236
          polar solvent 156
            1,1,1-trichloroethane 0
            3-methyl-2-butanol 0
            ethanol + 99
            ionic liquid + 0
            pentan-2-ol + 0
            polar aprotic solvent + 0
            protic solvent + 71
            protophilic solvent + 15
            pyrrolidin-2-one 0
paths to the root