CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: polar solvent
Accession: CHEBI:48354
browse the term
Definition: A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds.
Synonyms: related_synonym: polar solvents
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P2RY2
purinergic receptor P2Y2
multiple interactions
EXP
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP]
CTD
PMID:10604969
NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059
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CPNE6
copine 6
increases reduction
EXP
DHRS4 protein results in increased reduction of 9-cis-retinal
CTD
PMID:17827741
NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
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KCNJ3
potassium inwardly rectifying channel subfamily J member 3
multiple interactions
EXP
Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]
CTD
PMID:10666054
NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766
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KCNJ6
potassium inwardly rectifying channel subfamily J member 6
multiple interactions
EXP
Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]
CTD
PMID:10666054
NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478
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MAPK14
mitogen-activated protein kinase 14
multiple interactions
EXP
Acetylcholine results in increased phosphorylation of and results in increased activity of MAPK14 protein
CTD
PMID:9688607
NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603
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PTGS1
prostaglandin-endoperoxide synthase 1
decreases activity
EXP
Aspirin results in decreased activity of PTGS1 protein alternative form
CTD
PMID:12242329
NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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AGT
angiotensinogen
increases abundance
EXP
AGT results in increased abundance of Aldosterone
CTD
PMID:2831029
NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
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POMC
proopiomelanocortin
increases abundance
EXP
POMC protein results in increased abundance of Aldosterone
CTD
PMID:2831029
NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
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REN
renin
increases expression
EXP
Amlodipine results in increased expression of REN protein
CTD
PMID:10218729
NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
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ACHE
acetylcholinesterase
multiple interactions
EXP
[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein]
CTD
PMID:16915560
NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
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SCT
secretin
multiple interactions
EXP
Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates]
CTD
PMID:3562434
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DES
desmin
decreases expression
EXP
benazepril results in decreased expression of DES mRNA
CTD
PMID:20137276
NCBI chr37:25,933,525...25,939,910
Ensembl chr37:25,933,455...25,940,985
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ABCC1
ATP binding cassette subfamily C member 1
affects export
EXP
ABCC1 protein affects the export of calcein AM
CTD
PMID:12516967
NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
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AGT
angiotensinogen
decreases expression
EXP
Cilazapril results in decreased expression of AGT protein
CTD
PMID:2419701
NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
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REN
renin
increases activity
EXP
Cilazapril results in increased activity of REN protein
CTD
PMID:2419701
NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
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ACAA2
acetyl-CoA acyltransferase 2
increases expression
EXP
Clofibrate results in increased expression of ACAA2 mRNA
CTD
PMID:19952500
NCBI chr 7:79,028,636...79,057,720
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ACADVL
acyl-CoA dehydrogenase very long chain
increases expression
EXP
Clofibrate results in increased expression of ACADVL protein
CTD
PMID:19952500
NCBI chr 5:32,189,191...32,194,255
Ensembl chr 5:32,186,502...32,327,990
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AGXT
alanine--glyoxylate and serine--pyruvate aminotransferase
decreases expression
EXP
Clofibrate results in decreased expression of AGXT protein
CTD
PMID:19952500
NCBI chr25:50,968,291...50,976,089
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AHCY
adenosylhomocysteinase
decreases expression
EXP
Clofibrate results in decreased expression of AHCY protein
CTD
PMID:19952500
NCBI chr24:23,410,553...23,423,494
Ensembl chr24:23,411,140...23,419,767
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ASL
argininosuccinate lyase
increases expression
EXP
Clofibrate results in increased expression of ASL protein
CTD
PMID:19952500
NCBI chr 6:768,522...779,144
Ensembl chr 6:730,358...779,424
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ASS1
argininosuccinate synthase 1
decreases expression
EXP
Clofibrate results in decreased expression of ASS1 protein
CTD
PMID:19952500
NCBI chr 9:53,425,228...53,478,007
Ensembl chr 9:53,425,448...53,477,904
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CPS1
carbamoyl-phosphate synthase 1
increases expression
EXP
Clofibrate results in increased expression of CPS1 protein
CTD
PMID:19952500
NCBI chr37:18,308,164...18,428,487
Ensembl chr37:18,143,986...18,427,697
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CPT2
carnitine palmitoyltransferase 2
increases expression
EXP
Clofibrate results in increased expression of CPT2 mRNA
CTD
PMID:19952500
NCBI chr 5:55,718,209...55,786,175
Ensembl chr 5:55,718,510...55,744,809
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CYP1A2
cytochrome P450 family 1 subfamily A member 2
decreases expression
EXP
Clofibrate results in decreased expression of CYP1A2 mRNA
CTD
PMID:19952500
NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135
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CYP2A13
cytochrome P450 family 2 subfamily A polypeptide 13
decreases expression
EXP
Clofibrate results in decreased expression of CYP2A13 mRNA
CTD
PMID:19952500
NCBI chr 1:112,932,246...112,938,248
Ensembl chr 1:112,931,985...112,938,350
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CYP2B6
cytochrome P450 2B11
decreases expression
EXP
Clofibrate results in decreased expression of CYP2B6 mRNA
CTD
PMID:19952500
NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293
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CYP2C18
cytochrome P450 2C21
decreases expression
EXP
Clofibrate results in decreased expression of CYP2C18 mRNA
CTD
PMID:19952500
NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587
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CYP2E1
cytochrome P450 family 2 subfamily E member 1
increases expression
EXP
Clofibrate results in increased expression of CYP2E1 protein
CTD
PMID:19952500
NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754
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CYP3A12
cytochrome P-450 3A12
decreases expression
EXP
Clofibrate results in decreased expression of CYP3A12 mRNA
CTD
PMID:19952500
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CYP3A26
cytochrome P450 3A26
decreases expression
EXP
Clofibrate results in decreased expression of CYP3A26 mRNA
CTD
PMID:19952500
NCBI chr 6:9,777,663...9,815,345
Ensembl chr 6:9,777,659...9,869,352
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CYP4A37
cytochrome P450 4A37
increases expression
EXP
Clofibrate results in increased expression of CYP4A11 mRNA
CTD
PMID:19952500
NCBI chr15:13,604,130...13,623,797
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DLST
dihydrolipoamide S-succinyltransferase
increases expression
EXP
Clofibrate results in increased expression of DLST protein
CTD
PMID:19952500
NCBI chr 8:48,003,730...48,025,001
Ensembl chr 8:48,002,211...48,024,999
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ECHS1
enoyl-CoA hydratase, short chain 1
increases expression
EXP
Clofibrate results in increased expression of ECHS1 protein
CTD
PMID:19952500
NCBI chr28:40,939,856...40,947,694
Ensembl chr28:40,939,961...40,946,167
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GDI1
GDP dissociation inhibitor 1
increases expression
EXP
Clofibrate results in increased expression of GDI1 protein
CTD
PMID:19952500
NCBI chr X:122,141,633...122,146,724
Ensembl chr X:122,141,566...122,146,824
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GSTA4
glutathione S-transferase alpha 4
decreases expression
EXP
Clofibrate results in decreased expression of GSTA4 mRNA
CTD
PMID:19952500
NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200
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GSTK1
glutathione S-transferase kappa 1
decreases expression
EXP
Clofibrate results in decreased expression of GSTK1 mRNA
CTD
PMID:19952500
NCBI chr16:6,411,678...6,416,135
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GSTO1
glutathione S-transferase omega 1
decreases expression
EXP
Clofibrate results in decreased expression of GSTO1 mRNA
CTD
PMID:19952500
NCBI chr28:16,569,421...16,579,239
Ensembl chr28:16,569,066...16,619,880
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HADH
hydroxyacyl-CoA dehydrogenase
increases expression
EXP
Clofibrate results in increased expression of HADH mRNA
CTD
PMID:19952500
NCBI chr32:28,460,445...28,506,141
Ensembl chr32:28,460,193...28,531,280
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HSPD1
heat shock protein family D (Hsp60) member 1
increases expression
EXP
Clofibrate results in increased expression of HSPD1 protein
CTD
PMID:19952500
NCBI chr37:7,010,421...7,025,912
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KRT1
keratin 1
increases expression
EXP
Clofibrate results in increased expression of KRT1 protein
CTD
PMID:19952500
NCBI chr27:2,422,150...2,427,160
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KRT18
keratin 18
decreases expression
EXP
Clofibrate results in decreased expression of KRT18 protein
CTD
PMID:19952500
NCBI chr27:2,189,269...2,193,368
Ensembl chr27:2,189,269...2,193,368
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LOC474938
glutathione S-transferase A2
decreases expression
EXP
Clofibrate results in decreased expression of GSTA3 mRNA; Clofibrate results in decreased expression of GSTA3 protein
CTD
PMID:19952500
NCBI chr12:20,349,133...20,365,023
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MGST1
microsomal glutathione S-transferase 1
increases expression
EXP
Clofibrate results in increased expression of MGST1 mRNA
CTD
PMID:19952500
NCBI chr27:30,370,588...30,391,898
Ensembl chr27:30,370,594...30,391,778
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PC
pyruvate carboxylase
increases expression
EXP
Clofibrate results in increased expression of PC protein
CTD
PMID:19952500
NCBI chr18:50,406,994...50,507,677
Ensembl chr18:50,412,272...50,507,669
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PCK2
phosphoenolpyruvate carboxykinase 2, mitochondrial
increases expression
EXP
Clofibrate results in increased expression of PCK2 protein
CTD
PMID:19952500
NCBI chr 8:4,099,016...4,107,870
Ensembl chr 8:4,098,671...4,107,865
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PRDX6
peroxiredoxin 6
decreases expression
EXP
Clofibrate results in decreased expression of PRDX6 protein
CTD
PMID:19952500
NCBI chr 7:25,663,238...25,675,855
Ensembl chr 7:25,663,579...25,675,754
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SELENBP1
selenium binding protein 1
decreases expression
EXP
Clofibrate results in decreased expression of SELENBP1 protein
CTD
PMID:19952500
NCBI chr17:60,410,727...60,418,770
Ensembl chr17:60,410,734...60,418,704
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SHMT1
serine hydroxymethyltransferase 1
decreases expression
EXP
Clofibrate results in decreased expression of SHMT1 protein
CTD
PMID:19952500
NCBI chr 5:41,221,531...41,248,653
Ensembl chr 5:41,221,562...41,253,166
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UGP2
UDP-glucose pyrophosphorylase 2
decreases expression
EXP
Clofibrate results in decreased expression of UGP2 protein
CTD
PMID:19952500
NCBI chr10:63,532,366...63,598,362
Ensembl chr10:63,533,171...63,597,452
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UQCRC1
ubiquinol-cytochrome c reductase core protein 1
increases expression
EXP
Clofibrate results in increased expression of UQCRC1 protein
CTD
PMID:19952500
NCBI chr20:40,507,767...40,515,854
Ensembl chr20:40,506,907...40,520,110
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UROC1
urocanate hydratase 1
decreases expression
EXP
Clofibrate results in decreased expression of UROC1 protein
CTD
PMID:19952500
NCBI chr20:676,624...717,109
Ensembl chr20:678,073...717,141
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CYP2C18
cytochrome P450 2C21
increases hydroxylation
EXP
CYP2C19 protein results in increased hydroxylation of Diclofenac
CTD
PMID:15677349
NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587
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CYP2C41
cytochrome P450 2C41
affects metabolic processing
EXP
CYP2C9 protein affects the metabolism of Diclofenac
CTD
PMID:15801540
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PTGS1
prostaglandin-endoperoxide synthase 1
decreases activity
EXP
Diclofenac results in decreased activity of PTGS1 protein alternative form
CTD
PMID:12242329
NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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AR
androgen receptor
multiple interactions
EXP
Eplerenone binds to and results in decreased activity of AR protein
CTD
PMID:23242577
NCBI chr24:34,713,390...34,731,461 NCBI chr X:51,969,785...52,167,450
Ensembl chr X:51,969,785...52,151,912
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NR1I2
nuclear receptor subfamily 1 group I member 2
increases activity
EXP
Felodipine results in increased activity of NR1I2 protein
CTD
PMID:27732639
NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
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HEXB
hexosaminidase subunit beta
multiple interactions
EXP
Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein]
CTD
PMID:21671308
NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
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PTGS1
prostaglandin-endoperoxide synthase 1
decreases activity
EXP
Indomethacin results in decreased activity of PTGS1 protein alternative form
CTD
PMID:12242329
NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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CASP3
caspase 3
increases activity
EXP
Loratadine results in increased activity of CASP3 protein
CTD
PMID:20570632
NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
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CLDN4
claudin 4
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]
CTD
PMID:23816505
NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
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MAPK1
mitogen-activated protein kinase 1
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]
CTD
PMID:23816505
NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
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MAPK3
mitogen-activated protein kinase 3
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]
CTD
PMID:23816505
NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
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MAPK8
mitogen-activated protein kinase 8
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]
CTD
PMID:23816505
NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
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MAPK9
mitogen-activated protein kinase 9
multiple interactions
EXP
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]
CTD
PMID:23816505
NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
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REN
renin
decreases activity
EXP
Nitroglycerin results in decreased activity of REN protein
CTD
PMID:8640982
NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
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CYP1A2
cytochrome P450 family 1 subfamily A member 2
affects metabolic processing
EXP
CYP1A2 protein affects the metabolism of Phenacetin
CTD
PMID:15801540
NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135
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PTGS1
prostaglandin-endoperoxide synthase 1
decreases activity
EXP
Phenacetin results in decreased activity of PTGS1 protein alternative form
CTD
PMID:12242329
NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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CPNE6
copine 6
increases reduction
EXP
DHRS4 protein results in increased reduction of phenylglyoxylic acid
CTD
PMID:17827741
NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
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INS
insulin
multiple interactions
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein
CTD
PMID:12639917
NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
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MAPK1
mitogen-activated protein kinase 1
multiple interactions
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK1 protein
CTD
PMID:12639917
NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
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MAPK3
mitogen-activated protein kinase 3
multiple interactions
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; [Tetradecanoylphorbol Acetate co-treated with INS protein] results in increased phosphorylation of MAPK3 protein
CTD
PMID:12639917
NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
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SLC6A9
solute carrier family 6 member 9
multiple interactions affects localization
EXP
Tetradecanoylphorbol Acetate promotes the reaction [Monensin affects the localization of SLC6A9 protein] Tetradecanoylphorbol Acetate affects the localization of SLC6A9 protein
CTD
PMID:19473961
NCBI chr15:16,235,342...16,267,161
Ensembl chr15:16,235,482...16,267,933
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SOD1
superoxide dismutase 1
affects response to substance
EXP
SOD1 protein affects the susceptibility to Tetradecanoylphorbol Acetate
CTD
PMID:6333936
NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
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PTGS2
prostaglandin-endoperoxide synthase 2
decreases expression
EXP
Sulindac results in decreased expression of PTGS2 protein
CTD
PMID:12857884
NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
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RELA
RELA proto-oncogene, NF-kB subunit
decreases localization
EXP
Sulindac results in decreased localization of RELA protein
CTD
PMID:12857884
NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875
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NR1I2
nuclear receptor subfamily 1 group I member 2
increases activity
EXP
Troleandomycin results in increased activity of NR1I2 protein
CTD
PMID:27732639
NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
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ACHE
acetylcholinesterase
multiple interactions
EXP
[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein]
CTD
PMID:16915560
NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
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SCT
secretin
multiple interactions
EXP
Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates]
CTD
PMID:3562434
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ABCB1
ATP binding cassette subfamily B member 1
increases export multiple interactions affects response to substance
EXP
ABCB1 protein results in increased export of Vincristine valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]
CTD
PMID:24975508 PMID:28093773
NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
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ABCC1
ATP binding cassette subfamily C member 1
decreases response to substance
EXP
ABCC1 protein results in decreased susceptibility to Vincristine
CTD
PMID:12516967
NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
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PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
multiple interactions
EXP
Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein]
CTD
PMID:15958164
NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
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PRKCZ
protein kinase C zeta
multiple interactions
EXP
Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]
CTD
PMID:15958164
NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
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