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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:serine proteinase inhibitor
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Accession:CHEBI:48353 term browser browse the term
Definition:An exogenous or endogenous compound which inhibits serine endopeptidases.
Synonyms:related_synonym: serine proteinase inhibitors

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N-tosyl-L-phenylalanyl chloromethyl ketone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of ABCA1 mRNA] CTD PMID:12010990 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
affects localization		 ISO Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone affects the localization of AIFM1 protein] CTD PMID:19679660 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein] CTD PMID:17136479 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases activity EXP Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of ALDH2 protein CTD PMID:11142365 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO
EXP		 Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]] CTD PMID:10567916 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased expression of APOE mRNA]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased expression of CETP mRNA]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased secretion of APOE protein]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased secretion of CETP protein] CTD PMID:22056562 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased expression of APOE mRNA]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased secretion of APOE protein] CTD PMID:22056562 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases cleavage
multiple interactions		 ISO Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of BCL2 protein
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of BCL2 protein]		 CTD PMID:19679660 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
multiple interactions		 ISO Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC2 protein
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC2 protein]		 CTD PMID:19679660 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC3 protein] CTD PMID:19679660 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP3 protein
Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of and results in increased activity of CASP3 protein; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP3 protein]		 CTD PMID:12821135, PMID:19679660 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of and results in increased activity of CASP7 protein; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP7 protein] CTD PMID:12821135 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:19679660 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 ISO
EXP		 Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of CCL2 mRNA]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of CCL2 mRNA		 CTD PMID:12016129, PMID:12846738, PMID:15139008, PMID:16600694, PMID:18706406 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in increased expression of CDKN1A protein CTD PMID:12821135 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA] CTD PMID:17952619 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein] CTD PMID:17030184 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Ctsd cathepsin D increases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in increased expression of CTSD protein CTD PMID:10772776 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLC mRNA CTD PMID:22851183 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLM mRNA CTD PMID:22851183 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Hax1 HCLS1 associated protein X-1 multiple interactions
decreases response to substance
decreases expression		 ISO Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 protein]
HAX1 results in decreased susceptibility to Tosylphenylalanyl Chloromethyl Ketone
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 mRNA; Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 protein		 CTD PMID:19679660 NCBI chr 2:189,330,900...189,333,305
Ensembl chr 2:189,330,902...189,333,322 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP
ISO		 Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [resveratrol results in increased expression of HMOX1 mRNA]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [resveratrol results in increased expression of HMOX1 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [resveratrol results in increased expression of HMOX1 protein]		 CTD PMID:15588712, PMID:15965080 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of ICAM1 mRNA CTD PMID:11735124 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein promotes the reaction [RELA protein results in increased phosphorylation of IKBKG protein]] CTD PMID:17136479 NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of CXCL8 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of IL6 mRNA] CTD PMID:12016129 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein promotes the reaction [RELA protein results in increased phosphorylation of IKBKG protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of PDPK1 protein]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]		 CTD PMID:12010990, PMID:17136479 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of IL6 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased expression of IL6 mRNA]		 CTD PMID:10616907, PMID:10814840, PMID:12016129, PMID:15601679, PMID:17952619, PMID:18706406 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of ITGAM protein] CTD PMID:10739673 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity ISO Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of MMP9 protein CTD PMID:22033475 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to Tosylphenylalanyl Chloromethyl Ketone CTD PMID:22851183 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP		 Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [platycodin D results in increased activity of [NFKB1 protein binds to RELA protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased localization of [RELA protein co-treated with NFKB1 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of NFKB1 protein]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]]		 CTD PMID:10416616, PMID:10616907, PMID:11094054, PMID:12016129, PMID:16631160, PMID:17952619 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation
decreases degradation		 ISO
EXP		 [Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of RELA protein] inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of RELA protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased degradation of NFKBIA protein]
Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIA protein
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]
Tosylphenylalanyl Chloromethyl Ketone results in decreased degradation of NFKBIA protein		 CTD PMID:9580637, PMID:10381628, PMID:10921504, PMID:12574206, PMID:15687330, PMID:16288038, PMID:17952619, PMID:18449507, PMID:18666753 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions
decreases phosphorylation		 ISO Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIB protein]; Cysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIB protein] CTD PMID:10381628 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:15601679, PMID:18449507 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in increased expression of NQO1 mRNA CTD PMID:22851183 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nrg1 neuregulin 1 multiple interactions EXP Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [NRG1 protein results in increased transport of Glucose] CTD PMID:14711829 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of PARP1 protein] CTD PMID:19679660 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pde5a phosphodiesterase 5A decreases expression EXP Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of PDE5A mRNA CTD PMID:12466227 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 multiple interactions
decreases activity		 ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of PDPK1 protein]
Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of PDPK1 protein		 CTD PMID:17136479 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448 		JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of PLAU protein CTD PMID:10467400 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA] CTD PMID:9580637, PMID:17944529, PMID:18449507 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
affects activity		 ISO
EXP		 [Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of RELA protein] inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of RELA protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein promotes the reaction [RELA protein results in increased phosphorylation of IKBKG protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [platycodin D results in increased activity of [NFKB1 protein binds to RELA protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased transport of RELA protein]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased localization of [RELA protein co-treated with NFKB1 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of RELA protein]
Tosylphenylalanyl Chloromethyl Ketone affects the activity of RELA protein		 CTD PMID:10416616, PMID:10467400, PMID:10616907, PMID:10640779, PMID:11094054, PMID:12016129, PMID:15687330, PMID:16288038, PMID:16631160, PMID:17136479, PMID:17952619, PMID:18706406 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCARB1 mRNA] CTD PMID:12010990 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein] CTD PMID:10616907 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Sts steroid sulfatase multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750 		JBrowse link
G Tcf4 transcription factor 4 multiple interactions ISO Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]] CTD PMID:17030184 NCBI chr18:65,285,320...65,507,983
Ensembl chr18:65,155,685...65,507,977 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of RELA protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein] CTD PMID:16288038 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of RELA protein] inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased transport of RELA protein]
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of RELA protein]		 CTD PMID:7476933, PMID:9580637, PMID:10416616, PMID:10616907, PMID:10640779, PMID:12574206, PMID:15601679, PMID:15687330, PMID:18706406 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression
increases response to substance		 ISO Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of and results in increased activity of TP53 protein; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP3 protein]; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP7 protein]
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of TRP53 protein
TP53 protein results in increased susceptibility to Tosylphenylalanyl Chloromethyl Ketone		 CTD PMID:11536013, PMID:12821135 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of VCAM1 mRNA CTD PMID:11735124 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions
increases cleavage		 ISO Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of XIAP protein] CTD PMID:19679660 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000 		JBrowse link
phenylmethanesulfonyl fluoride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase multiple interactions ISO Phenylmethylsulfonyl Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin]; Phenylmethylsulfonyl Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Phenylmethylsulfonyl Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of rifapentine] CTD PMID:21856291 NCBI chr 2:150,146,234...150,157,480
Ensembl chr 2:150,146,234...150,157,480 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Phenylmethylsulfonyl Fluoride binds to and results in decreased activity of ACHE protein CTD PMID:31226285 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity		 ISO Phenylmethylsulfonyl Fluoride inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]; Phenylmethylsulfonyl Fluoride inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate]
Phenylmethylsulfonyl Fluoride results in decreased activity of BCHE protein		 CTD PMID:28299395 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Phenylmethylsulfonyl Fluoride inhibits the reaction [phenylsaligenin cyclic phosphate results in increased activity of CASP3 protein]; Phenylmethylsulfonyl Fluoride inhibits the reaction [tri-o-cresyl phosphate results in increased activity of CASP3 protein] CTD PMID:11032765 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Ces1d carboxylesterase 1D decreases activity ISO Phenylmethylsulfonyl Fluoride results in decreased activity of CES1 protein CTD PMID:11950785 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Phenylmethylsulfonyl Fluoride results in decreased activity of CES2 protein CTD PMID:11950785 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156 		JBrowse link
G Ces3a carboxylesterase 3a decreases activity ISO Phenylmethylsulfonyl Fluoride results in decreased activity of CES3 protein CTD PMID:11950785 NCBI chr19:37,070,705...37,079,411 JBrowse link
G Faah fatty acid amide hydrolase decreases activity ISO
EXP		 Phenylmethylsulfonyl Fluoride results in decreased activity of FAAH protein CTD PMID:16100529 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775 		JBrowse link
G Faahl fatty-acid amide hydrolase-like decreases activity ISO Phenylmethylsulfonyl Fluoride results in decreased activity of FAAH protein CTD PMID:16100529 NCBI chr 5:134,330,204...134,349,400
Ensembl chr 5:134,331,929...134,348,995 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases degradation EXP Phenylmethylsulfonyl Fluoride results in decreased degradation of IGFBP5 protein CTD PMID:8894652 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity ISO Phenylmethylsulfonyl Fluoride results in decreased activity of PNPLA6 protein CTD PMID:19620706 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO Phenylmethylsulfonyl Fluoride promotes the reaction [anandamide binds to and results in increased activity of TRPV1 protein] CTD PMID:11278420 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679 		JBrowse link
rosmarinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions		 EXP rosmarinic acid results in decreased expression of ACTA2 protein
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]		 CTD PMID:28789951 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions
decreases expression		 ISO [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein] CTD PMID:23774263 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO rosmarinic acid inhibits the reaction [Cadmium affects the localization of AIFM1 protein] CTD PMID:23548128 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 rosmarinic acid inhibits the reaction [Cadmium results in increased activity of CASP3 protein]
rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]		 CTD PMID:23548128, PMID:28815802 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression		 ISO rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein]; rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CAT mRNA]
rosmarinic acid results in increased activity of CAT protein
rosmarinic acid results in increased expression of CAT mRNA		 CTD PMID:31610155 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions
decreases expression		 EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]
rosmarinic acid results in decreased expression of CCN2 mRNA		 CTD PMID:28789951 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein] CTD PMID:28789951 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cd68 Cd68 molecule decreases expression EXP rosmarinic acid results in decreased expression of CD68 protein CTD PMID:28789951 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions		 ISO
EXP		 rosmarinic acid results in decreased expression of COL1A1 mRNA
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]		 CTD PMID:27235791, PMID:28789951 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions
decreases expression		 EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]
rosmarinic acid results in decreased expression of COL3A1 mRNA		 CTD PMID:28789951 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217 		JBrowse link
G Crp C-reactive protein affects expression
multiple interactions		 EXP rosmarinic acid affects the expression of CRP protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of CRP protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of CRP protein]		 CTD PMID:28744220 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
decreases expression		 ISO rosmarinic acid inhibits the reaction [Particulate Matter results in increased expression of CXCL1 protein]; rosmarinic acid inhibits the reaction [Vehicle Emissions results in increased expression of CXCL1 protein]
rosmarinic acid results in decreased expression of CXCL1 mRNA		 CTD PMID:12684091, PMID:26804033 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595 		JBrowse link
G Des desmin multiple interactions EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein] CTD PMID:28789951 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO rosmarinic acid results in decreased expression of DNMT1 protein CTD PMID:21078381 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495 		JBrowse link
G Fn1 fibronectin 1 decreases expression ISO rosmarinic acid results in decreased expression of FN1 mRNA CTD PMID:26804033 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP rosmarinic acid results in decreased expression of FOS protein CTD PMID:28789951 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gpt glutamic--pyruvic transaminase decreases activity EXP rosmarinic acid results in decreased activity of GPT protein CTD PMID:25455894 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression		 ISO rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX1 mRNA]
rosmarinic acid results in increased expression of GPX1 mRNA		 CTD PMID:31610155 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression
multiple interactions		 ISO rosmarinic acid results in increased expression of GSTO1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GSTO1 mRNA]		 CTD PMID:31610155 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387 		JBrowse link
G Hmgb1 high mobility group box 1 decreases expression EXP rosmarinic acid results in decreased expression of HMGB1 protein CTD PMID:28789951 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO rosmarinic acid results in increased expression of HMOX1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA]		 CTD PMID:31610155 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO
EXP		 [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]
rosmarinic acid results in decreased expression of IL1B mRNA; rosmarinic acid results in decreased expression of IL1B protein
rosmarinic acid inhibits the reaction [Cadmium results in increased expression of IL1B protein]; rosmarinic acid inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]; rosmarinic acid inhibits the reaction [Vehicle Emissions results in increased expression of IL1B protein]		 CTD PMID:12684091, PMID:23548128, PMID:23774263, PMID:25455894, PMID:28789951 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
affects expression
increases expression		 ISO
EXP		 rosmarinic acid inhibits the reaction [Cadmium results in increased expression of IL6 protein]
rosmarinic acid results in decreased expression of IL6 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of IL6 protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of IL6 protein]
rosmarinic acid results in increased expression of IL6 mRNA
rosmarinic acid results in decreased expression of IL6 mRNA		 CTD PMID:23548128, PMID:26804033, PMID:28744220, PMID:28789951 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of JUN protein CTD PMID:28789951 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Kcnu1 potassium calcium-activated channel subfamily U member 1 decreases activity ISO rosmarinic acid results in decreased activity of KCNU1 protein CTD PMID:30009954 NCBI chr16:70,913,825...70,998,593
Ensembl chr16:70,913,817...70,998,575 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
decreases expression		 ISO rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein]
rosmarinic acid results in decreased expression of KEAP1 protein		 CTD PMID:31610155 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO rosmarinic acid results in decreased activity of MAOA protein CTD PMID:27270453 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Maob monoamine oxidase B decreases activity ISO rosmarinic acid results in decreased activity of MAOB protein CTD PMID:27270453 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAP3K7 protein CTD PMID:28789951 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK1 protein CTD PMID:28789951 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK3 protein CTD PMID:28789951 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK8 protein CTD PMID:28789951 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases phosphorylation EXP rosmarinic acid results in decreased phosphorylation of MAPK9 protein CTD PMID:28789951 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP rosmarinic acid results in decreased expression of MMP2 mRNA; rosmarinic acid results in decreased expression of MMP2 protein CTD PMID:28789951 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP rosmarinic acid results in decreased expression of MMP9 mRNA; rosmarinic acid results in decreased expression of MMP9 protein CTD PMID:28789951 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mpo myeloperoxidase decreases expression EXP rosmarinic acid results in decreased expression of MPO protein CTD PMID:28789951 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor decreases expression EXP rosmarinic acid results in decreased expression of MYD88 protein CTD PMID:28789951 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression		 ISO [lead acetate results in increased abundance of Lead] inhibits the reaction [rosmarinic acid results in increased expression of NFE2L2 protein]; rosmarinic acid affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]
rosmarinic acid results in increased expression of NFE2L2 mRNA; rosmarinic acid results in increased expression of NFE2L2 protein		 CTD PMID:31610155 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions		 EXP rosmarinic acid results in decreased expression of NOS2 protein
rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]		 CTD PMID:25455894, PMID:28815802 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression EXP rosmarinic acid results in decreased expression of NOS3 protein CTD PMID:25455894 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO rosmarinic acid results in increased expression of NQO1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of NQO1 mRNA]		 CTD PMID:31610155 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression EXP rosmarinic acid results in increased expression of OGG1 mRNA CTD PMID:18996367 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326 		JBrowse link
G Parg poly (ADP-ribose) glycohydrolase decreases activity ISO rosmarinic acid results in decreased activity of PARG protein CTD PMID:19840838 NCBI chr16:8,350,168...8,457,999
Ensembl chr16:8,350,326...8,457,996 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression
multiple interactions		 EXP rosmarinic acid affects the expression of PPARG mRNA; rosmarinic acid affects the expression of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of PPARG mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of PPARG protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of PPARG mRNA]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of PPARG protein]		 CTD PMID:28744220 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Procr protein C receptor multiple interactions
affects localization		 ISO [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PROCR protein]; rosmarinic acid results in decreased cleavage of and results in decreased secretion of PROCR protein
rosmarinic acid affects the localization of PROCR protein		 CTD PMID:23774263 NCBI chr 3:151,285,321...151,289,581
Ensembl chr 3:151,285,249...151,289,595 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
decreases phosphorylation
affects expression
multiple interactions		 EXP rosmarinic acid affects the localization of RELA protein
rosmarinic acid results in decreased phosphorylation of RELA protein
rosmarinic acid affects the expression of RELA mRNA; rosmarinic acid affects the expression of RELA protein
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of RELA mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of RELA protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of RELA mRNA]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of RELA protein]		 CTD PMID:25455894, PMID:28744220, PMID:28789951 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO rosmarinic acid results in decreased expression of SERPINE1 mRNA CTD PMID:26804033 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions		 ISO rosmarinic acid results in increased expression of SOD1 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD1 mRNA]		 CTD PMID:31610155 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions		 ISO rosmarinic acid results in increased expression of SOD2 mRNA
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD2 mRNA]		 CTD PMID:31610155 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions		 EXP rosmarinic acid results in decreased expression of TGFB1 protein
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]		 CTD PMID:28789951 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression EXP rosmarinic acid results in decreased expression of TLR4 protein CTD PMID:28789951 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
decreases expression		 ISO
EXP		 [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of TNF protein]; rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of TNF protein]
rosmarinic acid results in decreased expression of TNF mRNA; rosmarinic acid results in decreased expression of TNF protein		 CTD PMID:23774263, PMID:25455894, PMID:28744220, PMID:28789951, PMID:28815802 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vim vimentin multiple interactions EXP rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:28789951 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        inhibitor 18238
          enzyme inhibitor 18163
            EC 3.* (hydrolase) inhibitor 17660
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 3219
                protease inhibitor 2045
                  serine proteinase inhibitor 103
                    N-tosyl-L-phenylalanyl chloromethyl ketone 53
                    phenylmethanesulfonyl fluoride 12
                    rosmarinic acid + 53
                    sitagliptin + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.