|
G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of ABCA1 mRNA] |
CTD |
PMID:12010990 |
|
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
|
|
G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions affects localization |
ISO |
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone affects the localization of AIFM1 protein] |
CTD |
PMID:19679660 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:17136479 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Aldh2 |
aldehyde dehydrogenase 2 family member |
decreases activity |
EXP |
Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of ALDH2 protein |
CTD |
PMID:11142365 |
|
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
|
|
G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
ISO EXP |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tunicamycin inhibits the reaction [Tretinoin results in increased activity of ALPL protein]] |
CTD |
PMID:10567916 |
|
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
|
|
G |
Apoa1 |
apolipoprotein A1 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [bisphenol A results in decreased expression of APOA1 mRNA]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased expression of APOE mRNA]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased expression of CETP mRNA]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased secretion of APOE protein]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased secretion of CETP protein] |
CTD |
PMID:22056562 PMID:31842455 |
|
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
|
|
G |
Apoe |
apolipoprotein E |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased expression of APOE mRNA]; Tosylphenylalanyl Chloromethyl Ketone promotes the reaction [APOA1 protein results in increased secretion of APOE protein] |
CTD |
PMID:22056562 |
|
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
increases cleavage multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of BCL2 protein Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of BCL2 protein] |
CTD |
PMID:19679660 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases expression multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC2 protein Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC2 protein] |
CTD |
PMID:19679660 |
|
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
|
|
G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions decreases expression |
ISO |
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of BIRC3 protein] |
CTD |
PMID:19679660 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
|
|
G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP3 protein Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of and results in increased activity of CASP3 protein; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP3 protein] |
CTD |
PMID:12821135 PMID:19679660 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of and results in increased activity of CASP7 protein; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP7 protein] |
CTD |
PMID:12821135 |
|
NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of and results in increased activity of CASP9 protein |
CTD |
PMID:19679660 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions decreases expression |
ISO EXP |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of CCL2 mRNA] Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of CCL2 mRNA Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] |
CTD |
PMID:12016129 PMID:12846738 PMID:15139008 PMID:16600694 PMID:18706406 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased expression of CDKN1A protein |
CTD |
PMID:12821135 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
EXP |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA] |
CTD |
PMID:17952619 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
|
|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein] |
CTD |
PMID:17030184 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
|
|
G |
Ctsd |
cathepsin D |
increases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased expression of CTSD protein |
CTD |
PMID:10772776 |
|
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLC mRNA |
CTD |
PMID:22851183 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased expression of GCLM mRNA |
CTD |
PMID:22851183 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
|
|
G |
Hax1 |
HCLS1 associated protein X-1 |
multiple interactions decreases response to substance decreases expression |
ISO |
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 protein] HAX1 results in decreased susceptibility to Tosylphenylalanyl Chloromethyl Ketone Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 mRNA; Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of HAX1 protein |
CTD |
PMID:19679660 |
|
NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [resveratrol results in increased expression of HMOX1 mRNA] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [resveratrol results in increased expression of HMOX1 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [resveratrol results in increased expression of HMOX1 protein] |
CTD |
PMID:15588712 PMID:15965080 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
decreases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of ICAM1 mRNA |
CTD |
PMID:11735124 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Ikbkg |
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein promotes the reaction [RELA protein results in increased phosphorylation of IKBKG protein]] |
CTD |
PMID:17136479 |
|
NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
|
|
G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of CXCL8 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of IL6 mRNA] |
CTD |
PMID:12016129 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
|
|
G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] |
CTD |
PMID:7476933 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein promotes the reaction [RELA protein results in increased phosphorylation of IKBKG protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of PDPK1 protein] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA] |
CTD |
PMID:12010990 PMID:17136479 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of IL6 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased expression of IL6 mRNA] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]] |
CTD |
PMID:10616907 PMID:10814840 PMID:12016129 PMID:15601679 PMID:17952619 PMID:18706406 More...
|
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of ITGAM protein] |
CTD |
PMID:10739673 |
|
NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
decreases activity |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of MMP9 protein |
CTD |
PMID:22033475 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects response to substance |
ISO |
NFE2L2 protein affects the susceptibility to Tosylphenylalanyl Chloromethyl Ketone |
CTD |
PMID:22851183 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO EXP |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [platycodin D results in increased activity of [NFKB1 protein binds to RELA protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased localization of [RELA protein co-treated with NFKB1 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of NFKB1 protein] |
CTD |
PMID:10416616 PMID:10616907 PMID:11094054 PMID:12016129 PMID:16631160 PMID:17952619 More...
|
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions decreases degradation decreases phosphorylation |
ISO EXP |
[Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of RELA protein] inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of RELA protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein] Tosylphenylalanyl Chloromethyl Ketone results in decreased degradation of NFKBIA protein Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIA protein Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased degradation of NFKBIA protein] |
CTD |
PMID:9580637 PMID:10381628 PMID:10921504 PMID:12574206 PMID:15687330 PMID:16288038 PMID:17952619 PMID:18449507 PMID:18666753 More...
|
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nfkbib |
NFKB inhibitor beta |
multiple interactions decreases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIB protein]; Cysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIB protein] |
CTD |
PMID:10381628 |
|
NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] |
CTD |
PMID:15601679 PMID:18449507 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in increased expression of NQO1 mRNA |
CTD |
PMID:22851183 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
G |
Nrg1 |
neuregulin 1 |
multiple interactions |
EXP |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [NRG1 protein results in increased transport of Glucose] |
CTD |
PMID:14711829 |
|
NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of PARP1 protein] |
CTD |
PMID:19679660 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Pde5a |
phosphodiesterase 5A |
decreases expression |
EXP |
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of PDE5A mRNA |
CTD |
PMID:12466227 |
|
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
|
|
G |
Pdpk1 |
3-phosphoinositide dependent protein kinase-1 |
multiple interactions decreases activity |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of PDPK1 protein] Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of PDPK1 protein |
CTD |
PMID:17136479 |
|
NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
|
|
G |
Plau |
plasminogen activator, urokinase |
decreases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of PLAU protein |
CTD |
PMID:10467400 |
|
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA] |
CTD |
PMID:9580637 PMID:17944529 PMID:18449507 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions affects activity decreases activity |
ISO EXP |
[Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of RELA protein] inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of RELA protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein promotes the reaction [RELA protein results in increased phosphorylation of IKBKG protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [platycodin D results in increased activity of [NFKB1 protein binds to RELA protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased transport of RELA protein] Tosylphenylalanyl Chloromethyl Ketone affects the activity of RELA protein Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased localization of [RELA protein co-treated with NFKB1 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of RELA protein] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:10416616 PMID:10467400 PMID:10616907 PMID:10640779 PMID:11094054 PMID:12016129 PMID:15687330 PMID:16288038 PMID:16631160 PMID:17136479 PMID:17952619 PMID:18706406 More...
|
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Scarb1 |
scavenger receptor class B, member 1 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCARB1 mRNA] |
CTD |
PMID:12010990 |
|
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
|
|
G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 protein] |
CTD |
PMID:7476933 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein] |
CTD |
PMID:10616907 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
G |
Sts |
steroid sulfatase |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tretinoin results in increased activity of STS protein] |
CTD |
PMID:16178010 |
|
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
|
|
G |
Tcf4 |
transcription factor 4 |
multiple interactions |
ISO |
Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]] |
CTD |
PMID:17030184 |
|
NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
[Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of RELA protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:16288038 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of RELA protein] inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased activity of RELA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of SOD2 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased transport of RELA protein] Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of NFKB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of RELA protein] |
CTD |
PMID:7476933 PMID:9580637 PMID:10416616 PMID:10616907 PMID:10640779 PMID:12574206 PMID:15601679 PMID:15687330 PMID:18706406 More...
|
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions increases response to substance decreases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of and results in increased activity of TP53 protein; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP3 protein]; TP53 protein promotes the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased activity of CASP7 protein] TP53 protein results in increased susceptibility to Tosylphenylalanyl Chloromethyl Ketone Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of TRP53 protein |
CTD |
PMID:11536013 PMID:12821135 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Vcam1 |
vascular cell adhesion molecule 1 |
decreases expression |
ISO |
Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of VCAM1 mRNA |
CTD |
PMID:11735124 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
|
|
G |
Xiap |
X-linked inhibitor of apoptosis |
multiple interactions increases cleavage |
ISO |
Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of XIAP protein] |
CTD |
PMID:19679660 |
|
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
|
|
|
G |
Aadac |
arylacetamide deacetylase |
multiple interactions |
ISO |
Phenylmethylsulfonyl Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin]; Phenylmethylsulfonyl Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Phenylmethylsulfonyl Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of rifapentine] |
CTD |
PMID:21856291 |
|
NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734
|
|
G |
Ache |
acetylcholinesterase |
multiple interactions |
ISO |
Phenylmethylsulfonyl Fluoride binds to and results in decreased activity of ACHE protein |
CTD |
PMID:31226285 |
|
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
|
|
G |
Bche |
butyrylcholinesterase |
multiple interactions decreases activity |
ISO |
Phenylmethylsulfonyl Fluoride inhibits the reaction [BCHE protein results in increased hydrolysis of acetylthiocholine iodide]; Phenylmethylsulfonyl Fluoride inhibits the reaction [BCHE protein results in increased hydrolysis of phenyl valerate] Phenylmethylsulfonyl Fluoride results in decreased activity of BCHE protein |
CTD |
PMID:28299395 |
|
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
Phenylmethylsulfonyl Fluoride inhibits the reaction [phenylsaligenin cyclic phosphate results in increased activity of CASP3 protein]; Phenylmethylsulfonyl Fluoride inhibits the reaction [tri-o-cresyl phosphate results in increased activity of CASP3 protein] |
CTD |
PMID:11032765 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Ces1d |
carboxylesterase 1D |
decreases activity |
ISO |
Phenylmethylsulfonyl Fluoride results in decreased activity of CES1 protein |
CTD |
PMID:11950785 |
|
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
|
|
G |
Ces2h |
carboxylesterase 2H |
decreases activity |
ISO |
Phenylmethylsulfonyl Fluoride results in decreased activity of CES2 protein |
CTD |
PMID:11950785 |
|
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
|
|
G |
Ces3a |
carboxylesterase 3a |
decreases activity |
ISO |
Phenylmethylsulfonyl Fluoride results in decreased activity of CES3 protein |
CTD |
PMID:11950785 |
|
NCBI chr19:32,992,386...33,000,562
|
|
G |
Faah |
fatty acid amide hydrolase |
decreases activity |
ISO EXP |
Phenylmethylsulfonyl Fluoride results in decreased activity of FAAH protein |
CTD |
PMID:16100529 |
|
NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
|
|
G |
Igfbp5 |
insulin-like growth factor binding protein 5 |
decreases degradation |
EXP |
Phenylmethylsulfonyl Fluoride results in decreased degradation of IGFBP5 protein |
CTD |
PMID:8894652 |
|
NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
|
|
G |
Pnpla6 |
patatin-like phospholipase domain containing 6 |
decreases activity |
ISO |
Phenylmethylsulfonyl Fluoride results in decreased activity of PNPLA6 protein |
CTD |
PMID:19620706 |
|
NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734
|
|
G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
multiple interactions |
ISO |
Phenylmethylsulfonyl Fluoride promotes the reaction [anandamide binds to and results in increased activity of TRPV1 protein] |
CTD |
PMID:11278420 |
|
NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
|
|
|
G |
Acta2 |
actin alpha 2, smooth muscle |
decreases expression multiple interactions |
EXP |
rosmarinic acid results in decreased expression of ACTA2 protein rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] |
CTD |
PMID:28789951 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
|
|
G |
Adam17 |
ADAM metallopeptidase domain 17 |
multiple interactions decreases expression |
ISO |
[rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein] |
CTD |
PMID:23774263 |
|
NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
|
|
G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO |
rosmarinic acid inhibits the reaction [Cadmium affects the localization of AIFM1 protein] |
CTD |
PMID:23548128 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO EXP |
rosmarinic acid inhibits the reaction [Cadmium results in increased activity of CASP3 protein] rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein] |
CTD |
PMID:23548128 PMID:28815802 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cat |
catalase |
multiple interactions increases activity increases expression |
ISO |
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of CAT protein]; rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of CAT mRNA] rosmarinic acid results in increased activity of CAT protein rosmarinic acid results in increased expression of CAT mRNA |
CTD |
PMID:31610155 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Ccn2 |
cellular communication network factor 2 |
multiple interactions decreases expression |
EXP |
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein] rosmarinic acid results in decreased expression of CCN2 mRNA |
CTD |
PMID:28789951 |
|
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
|
|
G |
Ccnd1 |
cyclin D1 |
multiple interactions |
EXP |
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein] |
CTD |
PMID:28789951 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
|
|
G |
Cd68 |
Cd68 molecule |
decreases expression |
EXP |
rosmarinic acid results in decreased expression of CD68 protein |
CTD |
PMID:28789951 |
|
NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
|
|
G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression multiple interactions |
ISO EXP |
rosmarinic acid results in decreased expression of COL1A1 mRNA rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] |
CTD |
PMID:27235791 PMID:28789951 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
|
|
G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions decreases expression |
EXP |
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA] rosmarinic acid results in decreased expression of COL3A1 mRNA |
CTD |
PMID:28789951 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
|
|
G |
Crp |
C-reactive protein |
affects expression multiple interactions |
EXP |
rosmarinic acid affects the expression of CRP protein 2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of CRP protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of CRP protein] |
CTD |
PMID:28744220 |
|
NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
|
|
G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions decreases expression |
ISO |
rosmarinic acid inhibits the reaction [Particulate Matter results in increased expression of CXCL1 protein]; rosmarinic acid inhibits the reaction [Vehicle Emissions results in increased expression of CXCL1 protein] rosmarinic acid results in decreased expression of CXCL1 mRNA |
CTD |
PMID:12684091 PMID:26804033 |
|
NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
|
|
G |
Des |
desmin |
multiple interactions |
EXP |
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein] |
CTD |
PMID:28789951 |
|
NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
|
|
G |
Dnmt1 |
DNA methyltransferase 1 |
decreases expression |
ISO |
rosmarinic acid results in decreased expression of DNMT1 protein |
CTD |
PMID:21078381 |
|
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
|
|
G |
Fn1 |
fibronectin 1 |
decreases expression |
ISO |
rosmarinic acid results in decreased expression of FN1 mRNA |
CTD |
PMID:26804033 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
EXP |
rosmarinic acid results in decreased expression of FOS protein |
CTD |
PMID:28789951 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
decreases activity |
EXP |
rosmarinic acid results in decreased activity of GPT protein |
CTD |
PMID:25455894 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions increases expression |
ISO |
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GPX1 mRNA] rosmarinic acid results in increased expression of GPX1 mRNA |
CTD |
PMID:31610155 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
|
|
G |
Gsto1 |
glutathione S-transferase omega 1 |
increases expression multiple interactions |
ISO |
rosmarinic acid results in increased expression of GSTO1 mRNA rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GSTO1 mRNA] |
CTD |
PMID:31610155 |
|
NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
|
|
G |
Hmgb1 |
high mobility group box 1 |
decreases expression |
EXP |
rosmarinic acid results in decreased expression of HMGB1 protein |
CTD |
PMID:28789951 |
|
NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO |
rosmarinic acid results in increased expression of HMOX1 mRNA rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 mRNA] |
CTD |
PMID:31610155 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions decreases expression |
ISO EXP |
[rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein] rosmarinic acid results in decreased expression of IL1B mRNA; rosmarinic acid results in decreased expression of IL1B protein rosmarinic acid inhibits the reaction [Cadmium results in increased expression of IL1B protein]; rosmarinic acid inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]; rosmarinic acid inhibits the reaction [Vehicle Emissions results in increased expression of IL1B protein] |
CTD |
PMID:12684091 PMID:23548128 PMID:23774263 PMID:25455894 PMID:28789951 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions decreases expression affects expression increases expression |
ISO EXP |
rosmarinic acid inhibits the reaction [Cadmium results in increased expression of IL6 protein] rosmarinic acid results in decreased expression of IL6 protein 2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of IL6 protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of IL6 protein] rosmarinic acid results in increased expression of IL6 mRNA rosmarinic acid results in decreased expression of IL6 mRNA |
CTD |
PMID:23548128 PMID:26804033 PMID:28744220 PMID:28789951 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases phosphorylation |
EXP |
rosmarinic acid results in decreased phosphorylation of JUN protein |
CTD |
PMID:28789951 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
|
|
G |
Kcnu1 |
potassium calcium-activated channel subfamily U member 1 |
decreases activity |
ISO |
rosmarinic acid results in decreased activity of KCNU1 protein |
CTD |
PMID:30009954 |
|
NCBI chr16:66,141,696...66,229,493
Ensembl chr16:66,141,976...66,229,465
|
|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions decreases expression |
ISO |
rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of KEAP1 protein] rosmarinic acid results in decreased expression of KEAP1 protein |
CTD |
PMID:31610155 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
|
|
G |
Maoa |
monoamine oxidase A |
decreases activity |
ISO |
rosmarinic acid results in decreased activity of MAOA protein |
CTD |
PMID:27270453 |
|
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
|
|
G |
Maob |
monoamine oxidase B |
decreases activity |
ISO |
rosmarinic acid results in decreased activity of MAOB protein |
CTD |
PMID:27270453 |
|
NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
|
|
G |
Map3k7 |
mitogen activated protein kinase kinase kinase 7 |
decreases phosphorylation |
EXP |
rosmarinic acid results in decreased phosphorylation of MAP3K7 protein |
CTD |
PMID:28789951 |
|
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation |
EXP |
rosmarinic acid results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:28789951 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation |
EXP |
rosmarinic acid results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:28789951 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
decreases phosphorylation |
EXP |
rosmarinic acid results in decreased phosphorylation of MAPK8 protein |
CTD |
PMID:28789951 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
decreases phosphorylation |
EXP |
rosmarinic acid results in decreased phosphorylation of MAPK9 protein |
CTD |
PMID:28789951 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression |
EXP |
rosmarinic acid results in decreased expression of MMP2 mRNA; rosmarinic acid results in decreased expression of MMP2 protein |
CTD |
PMID:28789951 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression |
EXP |
rosmarinic acid results in decreased expression of MMP9 mRNA; rosmarinic acid results in decreased expression of MMP9 protein |
CTD |
PMID:28789951 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G |
Mpo |
myeloperoxidase |
decreases expression |
EXP |
rosmarinic acid results in decreased expression of MPO protein |
CTD |
PMID:28789951 |
|
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
decreases expression |
EXP |
rosmarinic acid results in decreased expression of MYD88 protein |
CTD |
PMID:28789951 |
|
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression |
ISO |
[lead acetate results in increased abundance of Lead] inhibits the reaction [rosmarinic acid results in increased expression of NFE2L2 protein]; rosmarinic acid affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA] rosmarinic acid results in increased expression of NFE2L2 mRNA; rosmarinic acid results in increased expression of NFE2L2 protein |
CTD |
PMID:31610155 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nos2 |
nitric oxide synthase 2 |
decreases expression multiple interactions |
EXP |
rosmarinic acid results in decreased expression of NOS2 protein rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein] |
CTD |
PMID:25455894 PMID:28815802 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nos3 |
nitric oxide synthase 3 |
decreases expression |
EXP |
rosmarinic acid results in decreased expression of NOS3 protein |
CTD |
PMID:25455894 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO |
rosmarinic acid results in increased expression of NQO1 mRNA rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of NQO1 mRNA] |
CTD |
PMID:31610155 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
G |
Ogg1 |
8-oxoguanine DNA glycosylase |
increases expression |
EXP |
rosmarinic acid results in increased expression of OGG1 mRNA |
CTD |
PMID:18996367 |
|
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
|
|
G |
Parg |
poly (ADP-ribose) glycohydrolase |
decreases activity |
ISO |
rosmarinic acid results in decreased activity of PARG protein |
CTD |
PMID:19840838 |
|
NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
affects expression multiple interactions |
EXP |
rosmarinic acid affects the expression of PPARG mRNA; rosmarinic acid affects the expression of PPARG protein 2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of PPARG mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of PPARG protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of PPARG mRNA]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of PPARG protein] |
CTD |
PMID:28744220 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G |
Procr |
protein C receptor |
multiple interactions affects localization |
ISO |
[rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [IL1B protein results in increased cleavage of and results in increased secretion of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]; rosmarinic acid inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PROCR protein]; rosmarinic acid results in decreased cleavage of and results in decreased secretion of PROCR protein rosmarinic acid affects the localization of PROCR protein |
CTD |
PMID:23774263 |
|
NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
affects localization decreases phosphorylation affects expression multiple interactions |
EXP |
rosmarinic acid affects the localization of RELA protein rosmarinic acid results in decreased phosphorylation of RELA protein rosmarinic acid affects the expression of RELA mRNA; rosmarinic acid affects the expression of RELA protein 2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of RELA mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of RELA protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of RELA mRNA]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of RELA protein] |
CTD |
PMID:25455894 PMID:28744220 PMID:28789951 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G |
Serpine1 |
serpin family E member 1 |
decreases expression |
ISO |
rosmarinic acid results in decreased expression of SERPINE1 mRNA |
CTD |
PMID:26804033 |
|
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
|
|
G |
Sod1 |
superoxide dismutase 1 |
increases expression multiple interactions |
ISO |
rosmarinic acid results in increased expression of SOD1 mRNA rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD1 mRNA] |
CTD |
PMID:31610155 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
|
|
G |
Sod2 |
superoxide dismutase 2 |
increases expression multiple interactions |
ISO |
rosmarinic acid results in increased expression of SOD2 mRNA rosmarinic acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SOD2 mRNA] |
CTD |
PMID:31610155 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases expression multiple interactions |
EXP |
rosmarinic acid results in decreased expression of TGFB1 protein rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein]; rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] |
CTD |
PMID:28789951 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tlr4 |
toll-like receptor 4 |
decreases expression |
EXP |
rosmarinic acid results in decreased expression of TLR4 protein |
CTD |
PMID:28789951 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions affects expression decreases expression |
ISO EXP |
[rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [rosmarinic acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein] 2-chloro-5-nitrobenzanilide inhibits the reaction [rosmarinic acid affects the expression of TNF protein]; rosmarinic acid inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; T 0070907 inhibits the reaction [rosmarinic acid affects the expression of TNF protein] rosmarinic acid results in decreased expression of TNF mRNA; rosmarinic acid results in decreased expression of TNF protein |
CTD |
PMID:23774263 PMID:25455894 PMID:28744220 PMID:28789951 PMID:28815802 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Vim |
vimentin |
multiple interactions |
EXP |
rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] |
CTD |
PMID:28789951 |
|
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
|
|