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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triclocarban
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Accession:CHEBI:48347 term browser browse the term
Definition:A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.
Synonyms:related_synonym: 1-(3',4'-dichlorophenyl)-3-(4'-chlorophenyl)urea;   3,4,4'-trichloro carbanilide;   3,4,4'-trichlorocarbanilide;   3,4,4'-trichlorodiphenylurea;   Cutisan;   Formula=C13H9Cl3N2O;   InChI=1S/C13H9Cl3N2O/c14-8-1-3-9(4-2-8)17-13(19)18-10-5-6-11(15)12(16)7-10/h1-7H,(H2,17,18,19);   InChIKey=ICUTUKXCWQYESQ-UHFFFAOYSA-N;   N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea;   Nobacter;   SMILES=Clc1ccc(NC(=O)Nc2ccc(Cl)c(Cl)c2)cc1;   Solubacter;   TCC;   triclocarbanum
 xref: Beilstein:2814890;   CAS:101-20-2;   DrugBank:DB11155;   Drug_Central:3630;   KEGG:D06223
 xref_mesh: MESH:C009540
 xref: PMID:18048496;   PMID:24461429;   PMID:24464075;   PMID:24562054;   PMID:30033524;   Patent:GB769273;   Patent:US2818390;   Reaxys:2814890;   Wikipedia:Triclocarban


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triclocarban term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases expression EXP triclocarban results in increased expression of ACACA mRNA CTD PMID:31576746 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression
ISO
EXP
AHR mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA]
triclocarban results in increased expression of AHR mRNA; triclocarban results in increased expression of AHR protein
CTD PMID:23524099 PMID:31576746 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ar androgen receptor multiple interactions ISO triclocarban analog promotes the reaction [Testosterone results in increased activity of AR protein]; triclocarban promotes the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; triclocarban promotes the reaction [Testosterone results in increased activity of AR protein]; triclocarban promotes the reaction [Trenbolone Acetate results in increased activity of AR protein] CTD PMID:18795164 PMID:20821581 PMID:20943248 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO triclocarban results in increased expression of ATF4 protein CTD PMID:30592132 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO triclocarban results in increased expression of ATF6 mRNA; triclocarban results in increased expression of ATF6 protein CTD PMID:30592132 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Cers2 ceramide synthase 2 increases expression EXP triclocarban results in increased expression of CERS2 mRNA CTD PMID:31576746 NCBI chr 2:182,890,527...182,898,805
Ensembl chr 2:182,890,493...182,933,314
JBrowse link
G Cers6 ceramide synthase 6 increases expression EXP triclocarban results in increased expression of CERS6 mRNA CTD PMID:31576746 NCBI chr 3:53,630,636...53,879,692
Ensembl chr 3:53,630,959...53,876,848
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO
EXP
[bisphenol A co-treated with triclocarban] results in increased expression of CYP1A1 mRNA; [butylparaben co-treated with triclocarban] results in increased expression of CYP1A1 mRNA; [Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA; [Genistein co-treated with triclocarban] results in increased expression of CYP1A1 mRNA; AHR mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA]; ESR1 mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA]; triclocarban inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; triclocarban inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
triclocarban results in increased expression of CYP1A1 mRNA
CTD PMID:23524099 PMID:31576746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO
EXP
ESR1 protein affects the reaction [triclocarban results in increased expression of CYP1B1 mRNA]; triclocarban promotes the reaction [bisphenol A results in increased expression of CYP1B1 mRNA]; triclocarban promotes the reaction [Genistein results in increased expression of CYP1B1 mRNA] CTD PMID:22761658 PMID:23524099 PMID:31576746 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 protein]
triclocarban results in increased expression of CYP2B10 mRNA; triclocarban results in increased expression of CYP2B10 protein
CTD PMID:22761658 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO ESR1 protein affects the reaction [triclocarban results in increased expression of CYP2B6 mRNA] CTD PMID:22761658 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO triclocarban results in increased expression of EIF2AK3 protein modified form CTD PMID:30592132 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases expression ISO triclocarban results in increased expression of EIF2S1 protein modified form CTD PMID:30592132 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO ESR1 mutant form inhibits the reaction [[Estradiol co-treated with triclocarban] results in increased expression of CYP1A1 mRNA]; ESR1 protein affects the reaction [triclocarban results in increased expression of CYP1B1 mRNA]; ESR1 protein affects the reaction [triclocarban results in increased expression of CYP2B6 mRNA]; triclocarban analog promotes the reaction [Estradiol results in increased activity of ESR1 protein]; triclocarban promotes the reaction [Estradiol results in increased activity of ESR1 protein]
triclocarban results in decreased expression of ESR1 mRNA; triclocarban results in decreased expression of ESR1 protein
CTD PMID:18795164 PMID:22761658 PMID:23524099 PMID:24740835 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fasn fatty acid synthase increases expression EXP triclocarban results in increased expression of FASN mRNA CTD PMID:31576746 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Ffar2 free fatty acid receptor 2 increases expression EXP triclocarban results in increased expression of FFAR2 mRNA CTD PMID:31576746 NCBI chr 1:86,071,860...86,075,049
Ensembl chr 1:86,072,184...86,075,033
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 increases expression EXP triclocarban results in increased expression of GPER1 mRNA CTD PMID:31576746 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO triclocarban results in increased expression of HSPA5 mRNA; triclocarban results in increased expression of HSPA5 protein CTD PMID:30592132 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il10 interleukin 10 increases response to substance ISO IL10 gene mutant form results in increased susceptibility to triclocarban CTD PMID:31868902 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta increases expression EXP triclocarban results in increased expression of IL1B mRNA CTD PMID:31576746 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO
EXP
triclocarban inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]
triclocarban results in increased expression of IL6 mRNA
CTD PMID:21741984 PMID:31576746 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mir193b microRNA 193b increases expression ISO triclocarban results in increased expression of MIR193B mRNA CTD PMID:24740835 NCBI chr10:1,317,742...1,317,824
Ensembl chr10:1,317,742...1,317,824
JBrowse link
G Mir206 microRNA 206 increases expression ISO triclocarban results in increased expression of MIR206 mRNA CTD PMID:24740835 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332
JBrowse link
G Mir22 microRNA 22 increases expression ISO triclocarban results in increased expression of MIR22 mRNA CTD PMID:24740835 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A1 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A3 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A4 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A6 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A9 mRNA]
NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 protein]
CTD PMID:22761658 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP triclocarban results in increased expression of SCD mRNA CTD PMID:31576746 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Slc5a5 solute carrier family 5 member 5 decreases activity
multiple interactions
EXP
ISO
triclocarban results in decreased activity of SLC5A5 protein
triclocarban inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]
CTD PMID:26827900 PMID:27979590 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 increases expression EXP triclocarban results in increased expression of SPTLC2 mRNA CTD PMID:31576746 NCBI chr 6:106,948,681...107,031,584
Ensembl chr 6:106,950,949...107,031,542
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO triclocarban results in increased expression of TFF1 mRNA; triclocarban results in increased expression of TFF1 protein CTD PMID:24740835 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO triclocarban inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein] CTD PMID:21741984 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tpo thyroid peroxidase decreases activity EXP triclocarban results in decreased activity of TPO protein CTD PMID:26827900 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions
ISO triclocarban results in increased expression of UGT1A1 mRNA
NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A1 mRNA]
CTD PMID:22761658 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A3 mRNA] CTD PMID:22761658 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A4 mRNA] CTD PMID:22761658 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression
multiple interactions
ISO triclocarban results in increased expression of UGT1A6 mRNA
NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A6 mRNA]
CTD PMID:22761658 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases expression
multiple interactions
ISO triclocarban results in increased expression of UGT1A9 mRNA
NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A9 mRNA]
CTD PMID:22761658 NCBI chr 9:88,696,981...88,808,465 JBrowse link

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  CHEBI ontology 19812
    role 19761
      biological role 19761
        antimicrobial agent 17400
          triclocarban 36
Path 2
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                monocarboxylic acid amide 15014
                                                  urea 5112
                                                    ureas 5109
                                                      phenylureas 2043
                                                        1,3-diphenylurea 36
                                                          triclocarban 36
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