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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrazinopyridoindole
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Accession:CHEBI:48346 term browser browse the term
Synonyms:related_synonym: pyrazinopyridoindoles



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tadalafil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in increased expression of AIF1 protein] CTD PMID:31323263 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Tadalafil inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]]; Testosterone promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Testosterone promotes the reaction [Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]] CTD PMID:20574430 PMID:32621855 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
Tadalafil inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Tadalafil inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]; Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]]; Testosterone promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Testosterone promotes the reaction [Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]]
CTD PMID:20543097 PMID:20574430 PMID:32621855 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of BDNF protein] CTD PMID:31323263 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]] CTD PMID:32621855 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP Tadalafil inhibits the reaction [Cisplatin results in decreased expression of CAT protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of CAT protein]] CTD PMID:32621855 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased phosphorylation of CREB1 protein] CTD PMID:31323263 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Tadalafil results in increased activity of G6PD protein CTD PMID:24911673 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions ISO Tadalafil inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein] CTD PMID:20543097 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G Gcg glucagon decreases activity EXP Tadalafil results in decreased activity of GCG protein CTD PMID:24911673 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in increased expression of GFAP protein] CTD PMID:31323263 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of GRIA1 protein] CTD PMID:31323263 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of GRIA2 protein] CTD PMID:31323263 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of GRIN2A protein] CTD PMID:31323263 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased phosphorylation of GSK3B protein] CTD PMID:31323263 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA]; Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]] CTD PMID:32621855 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
EXP
ISO
Tadalafil inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]
Tadalafil inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]
Tadalafil results in decreased expression of IL1B mRNA
CTD PMID:16368379 PMID:31323263 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in increased expression of IL6 protein] CTD PMID:31323263 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Tadalafil results in increased phosphorylation of MAPK1 protein
Tadalafil inhibits the reaction [Thioacetamide results in increased phosphorylation of MAPK1 protein]
CTD PMID:18082193 PMID:31323263 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Tadalafil results in increased phosphorylation of MAPK3 protein
Tadalafil inhibits the reaction [Thioacetamide results in increased phosphorylation of MAPK3 protein]
CTD PMID:18082193 PMID:31323263 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Tadalafil promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA] CTD PMID:32621855 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Tadalafil inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]] CTD PMID:32621855 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pde5a phosphodiesterase 5A decreases activity ISO Tadalafil results in decreased activity of PDE5A protein CTD PMID:15934858 PMID:16368379 PMID:17138653 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions ISO [Tadalafil co-treated with Thioacetamide] results in increased expression of PRKG1 protein CTD PMID:31323263 NCBI chr 1:228,409,883...229,638,794 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in increased phosphorylation of RELA protein] CTD PMID:31323263 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Syp synaptophysin multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of SYP protein] CTD PMID:31323263 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
Tadalafil inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Tadalafil inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of TNF protein]]
Tadalafil inhibits the reaction [Thioacetamide results in increased expression of TNF protein]
Tadalafil results in decreased expression of TNF mRNA
CTD PMID:16368379 PMID:31323263 PMID:32621855 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          nitrogen atom 18767
            nitrogen molecular entity 18767
              organonitrogen compound 18544
                organonitrogen heterocyclic compound 17661
                  pyrazinopyridoindole 27
                    tadalafil 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteropolycyclic compound 18043
                                    organic heterotetracyclic compound 9073
                                      pyrazinopyridoindole 27
                                        tadalafil 27
paths to the root