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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrazinopyridoindole
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Accession:CHEBI:48346 term browser browse the term
Synonyms:related_synonym: pyrazinopyridoindoles


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tadalafil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in increased expression of AIF1 protein] CTD PMID:31323263 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Tadalafil inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]]; Testosterone promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Testosterone promotes the reaction [Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]] CTD PMID:20574430, PMID:32621855 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
Tadalafil inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]
Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Tadalafil inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]; Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]]; Testosterone promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Testosterone promotes the reaction [Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]]
CTD PMID:20543097, PMID:20574430, PMID:32621855 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of BDNF protein] CTD PMID:31323263 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]] CTD PMID:32621855 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions EXP Tadalafil inhibits the reaction [Cisplatin results in decreased expression of CAT protein]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in decreased expression of CAT protein]] CTD PMID:32621855 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased phosphorylation of CREB1 protein] CTD PMID:31323263 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Tadalafil results in increased activity of G6PD protein CTD PMID:24911673 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions ISO Tadalafil inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein] CTD PMID:20543097 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gcg glucagon decreases activity EXP Tadalafil results in decreased activity of GCG protein CTD PMID:24911673 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in increased expression of GFAP protein] CTD PMID:31323263 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of GRIA1 protein] CTD PMID:31323263 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of GRIA2 protein] CTD PMID:31323263 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of GRIN2A protein] CTD PMID:31323263 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased phosphorylation of GSK3B protein] CTD PMID:31323263 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA]; Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [Tadalafil promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]] CTD PMID:32621855 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
EXP
ISO
Tadalafil inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]
Tadalafil inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]
Tadalafil results in decreased expression of IL1B mRNA
CTD PMID:16368379, PMID:31323263 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in increased expression of IL6 protein] CTD PMID:31323263 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Tadalafil results in increased phosphorylation of MAPK1 protein
Tadalafil inhibits the reaction [Thioacetamide results in increased phosphorylation of MAPK1 protein]
CTD PMID:18082193, PMID:31323263 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Tadalafil results in increased phosphorylation of MAPK3 protein
Tadalafil inhibits the reaction [Thioacetamide results in increased phosphorylation of MAPK3 protein]
CTD PMID:18082193, PMID:31323263 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Tadalafil promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA] CTD PMID:32621855 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Tadalafil inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]] CTD PMID:32621855 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pde5a phosphodiesterase 5A decreases activity ISO Tadalafil results in decreased activity of PDE5A protein CTD PMID:15934858, PMID:16368379, PMID:17138653 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions ISO [Tadalafil co-treated with Thioacetamide] results in increased expression of PRKG1 protein CTD PMID:31323263 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in increased phosphorylation of RELA protein] CTD PMID:31323263 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Syp synaptophysin multiple interactions ISO Tadalafil inhibits the reaction [Thioacetamide results in decreased expression of SYP protein] CTD PMID:31323263 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
Tadalafil inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Tadalafil inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]; zinc protoporphyrin inhibits the reaction [Tadalafil inhibits the reaction [Cisplatin results in increased expression of TNF protein]]
Tadalafil inhibits the reaction [Thioacetamide results in increased expression of TNF protein]
Tadalafil results in decreased expression of TNF mRNA
CTD PMID:16368379, PMID:31323263, PMID:32621855 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          nitrogen atom 18565
            nitrogen molecular entity 18565
              organonitrogen compound 18338
                organonitrogen heterocyclic compound 17485
                  pyrazinopyridoindole 27
                    tadalafil 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteropolycyclic compound 17844
                                    organic heterotetracyclic compound 4654
                                      pyrazinopyridoindole 27
                                        tadalafil 27
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.