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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrazinecarboxylic acid
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Accession:CHEBI:48345 term browser browse the term
Synonyms:related_synonym: pyrazinecarboxylic acids


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5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO acipimox results in increased expression of ACADM mRNA CTD PMID:25352640 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma increases expression ISO acipimox results in increased expression of ATP5F1C mRNA CTD PMID:25352640 NCBI chr17:72,209,321...72,231,562
Ensembl chr17:72,209,373...72,394,271
JBrowse link
G Cd36 CD36 molecule increases expression ISO acipimox results in increased expression of CD36 mRNA CTD PMID:25352640 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cs citrate synthase increases expression ISO acipimox results in increased expression of CS mRNA CTD PMID:25352640 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO acipimox results in increased expression of CYCS mRNA CTD PMID:25352640 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G D2hgdh D-2-hydroxyglutarate dehydrogenase decreases expression ISO acipimox results in decreased expression of D2HGDH mRNA CTD PMID:25352640 NCBI chr 9:100,956,570...100,974,393
Ensembl chr 9:100,956,477...100,974,551
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase increases expression ISO acipimox results in increased expression of DLST mRNA CTD PMID:25352640 NCBI chr 6:108,936,534...108,961,322
Ensembl chr 6:108,936,664...108,959,803
JBrowse link
G Foxo1 forkhead box O1 increases expression ISO acipimox results in increased expression of FOXO1 mRNA CTD PMID:25352640 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Ghrh growth hormone releasing hormone affects response to substance ISO acipimox affects the susceptibility to GHRH protein CTD PMID:8923850 NCBI chr 3:153,449,124...153,468,794
Ensembl chr 3:153,449,125...153,468,794
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO acipimox results in increased expression of HSPD1 protein CTD PMID:25352640 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha increases expression ISO acipimox results in increased expression of IDH3A mRNA CTD PMID:25352640 NCBI chr 8:59,164,601...59,183,899
Ensembl chr 8:59,164,572...59,183,908
JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta decreases expression ISO acipimox results in decreased expression of IDH3B mRNA CTD PMID:25352640 NCBI chr 3:122,808,564...122,813,638
Ensembl chr 3:122,808,564...122,813,583
JBrowse link
G Ins2 insulin 2 decreases expression ISO acipimox results in decreased expression of INS protein CTD PMID:8923850 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G L2hgdh L-2-hydroxyglutarate dehydrogenase decreases expression ISO acipimox results in decreased expression of L2HGDH mRNA CTD PMID:25352640 NCBI chr 6:92,016,560...92,057,643
Ensembl chr 6:92,016,622...92,057,816
JBrowse link
G Ldhb lactate dehydrogenase B increases expression ISO acipimox results in increased expression of LDHB mRNA CTD PMID:25352640 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Mfn2 mitofusin 2 increases expression ISO acipimox results in increased expression of MFN2 mRNA CTD PMID:25352640 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO acipimox results in increased expression of COX1 mRNA; acipimox results in increased expression of COX1 protein CTD PMID:25352640 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II increases expression ISO acipimox results in increased expression of COX2 mRNA CTD PMID:25352640 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mt-nd6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 decreases expression ISO acipimox results in decreased expression of ND6 mRNA CTD PMID:25352640 NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061
JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 decreases expression ISO acipimox results in decreased expression of NDUFA1 mRNA CTD PMID:25352640 NCBI chr  X:123,803,109...123,806,760
Ensembl chr  X:124,513,269...124,516,705
Ensembl chr  X:124,513,269...124,516,705
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 increases expression ISO acipimox results in increased expression of NDUFA2 mRNA CTD PMID:25352640 NCBI chr18:29,585,671...29,587,760
Ensembl chr18:29,585,671...29,587,760
JBrowse link
G Ndufb1 NADH:ubiquinone oxidoreductase subunit B1 decreases expression ISO acipimox results in decreased expression of NDUFB1 mRNA CTD PMID:25352640 NCBI chr 6:125,861,219...125,870,231 JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 decreases expression ISO acipimox results in decreased expression of NDUFV1 mRNA CTD PMID:25352640 NCBI chr 1:219,254,293...219,259,328
Ensembl chr 1:219,254,279...219,259,448
JBrowse link
G Ogdh oxoglutarate dehydrogenase decreases expression ISO acipimox results in decreased expression of OGDH mRNA CTD PMID:25352640 NCBI chr14:86,414,924...86,481,903
Ensembl chr14:86,414,949...86,613,327
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO acipimox results in decreased expression of PDK1 mRNA CTD PMID:25352640 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 increases expression ISO acipimox results in increased expression of PDP2 mRNA CTD PMID:25352640 NCBI chr19:597,427...601,556
Ensembl chr19:597,427...601,469
JBrowse link
G Pdpr pyruvate dehydrogenase phosphatase regulatory subunit increases expression ISO acipimox results in increased expression of PDPR mRNA CTD PMID:25352640 NCBI chr19:43,107,852...43,149,243
Ensembl chr19:43,109,427...43,149,210
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO acipimox results in increased expression of PPARA mRNA CTD PMID:25352640 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO acipimox results in increased expression of PPARGC1A mRNA CTD PMID:25352640 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Slc16a3 solute carrier family 16 member 3 increases expression ISO acipimox results in increased expression of SLC16A3 mRNA CTD PMID:25352640 NCBI chr10:110,138,519...110,148,360
Ensembl chr10:110,138,586...110,148,358
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO acipimox results in increased expression of SOD2 mRNA CTD PMID:25352640 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sod3 superoxide dismutase 3 increases expression ISO acipimox results in increased expression of SOD3 mRNA CTD PMID:25352640 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta decreases expression ISO acipimox results in decreased expression of SUCLG2 mRNA CTD PMID:25352640 NCBI chr 4:127,552,100...127,824,970
Ensembl chr 4:127,552,101...127,824,970
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO acipimox results in increased expression of TFAM mRNA CTD PMID:25352640 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tnnt1 troponin T1, slow skeletal type increases expression ISO acipimox results in increased expression of TNNT1 mRNA CTD PMID:25352640 NCBI chr 1:72,889,270...72,899,629
Ensembl chr 1:72,889,270...72,899,659
JBrowse link
G Ucp2 uncoupling protein 2 increases expression ISO acipimox results in increased expression of UCP2 mRNA CTD PMID:25352640 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Ucp3 uncoupling protein 3 decreases expression
multiple interactions
ISO acipimox results in decreased expression of UCP3 mRNA
[Albuterol co-treated with acipimox] results in decreased expression of UCP3 mRNA
CTD PMID:12824081 PMID:25352640 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein increases expression ISO acipimox results in increased expression of UQCRH mRNA CTD PMID:25352640 NCBI chr 5:134,919,040...134,927,235
Ensembl chr 5:134,919,044...134,927,235
JBrowse link
pyrazine-2-carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acmsd aminocarboxymuconate semialdehyde decarboxylase decreases activity EXP pyrazinoic acid metabolite results in decreased activity of ACMSD protein CTD PMID:12224625 NCBI chr13:44,424,689...44,468,734
Ensembl chr13:44,424,689...44,468,734
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions EXP
ISO
pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:14747372 PMID:21074513 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO pyrazinoic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] CTD PMID:12472777 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      chemical role 19339
        donor 18471
          Bronsted acid 18323
            oxoacid 18273
              carbon oxoacid 18152
                carboxylic acid 18142
                  pyrazinecarboxylic acid 41
                    3-(\{cis-4-[(2-\{[2-(acetylamino)ethyl]disulfanyl\}ethyl)carbamoyl]cyclohexyl\}carbamoyl)pyrazine-2-carboxylic acid 0
                    5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid 38
                    6-methyl-1-oxido-pyrazin-1-ium-2-carboxylic acid 0
                    pyrazine-2-carboxylic acid 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      carboxylic acid 18142
                                        pyrazinecarboxylic acid 41
                                          3-(\{cis-4-[(2-\{[2-(acetylamino)ethyl]disulfanyl\}ethyl)carbamoyl]cyclohexyl\}carbamoyl)pyrazine-2-carboxylic acid 0
                                          5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid 38
                                          6-methyl-1-oxido-pyrazin-1-ium-2-carboxylic acid 0
                                          pyrazine-2-carboxylic acid 3
paths to the root