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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrazinecarboxylic acid
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Accession:CHEBI:48345 term browser browse the term
Synonyms:related_synonym: pyrazinecarboxylic acids



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5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO acipimox results in increased expression of ACADM mRNA CTD PMID:25352640 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma increases expression ISO acipimox results in increased expression of ATP5F1C mRNA CTD PMID:25352640 NCBI chr17:68,423,927...68,446,169 JBrowse link
G Cd36 CD36 molecule increases expression ISO acipimox results in increased expression of CD36 mRNA CTD PMID:25352640 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cs citrate synthase increases expression ISO acipimox results in increased expression of CS mRNA CTD PMID:25352640 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO acipimox results in increased expression of CYCS mRNA CTD PMID:25352640 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G D2hgdh D-2-hydroxyglutarate dehydrogenase decreases expression ISO acipimox results in decreased expression of D2HGDH mRNA CTD PMID:25352640 NCBI chr 9:94,350,555...94,368,384
Ensembl chr 9:94,350,576...94,368,382
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase increases expression ISO acipimox results in increased expression of DLST mRNA CTD PMID:25352640 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
JBrowse link
G Foxo1 forkhead box O1 increases expression ISO acipimox results in increased expression of FOXO1 mRNA CTD PMID:25352640 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Ghrh growth hormone releasing hormone affects response to substance ISO acipimox affects the susceptibility to GHRH protein CTD PMID:8923850 NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO acipimox results in increased expression of HSPD1 protein CTD PMID:25352640 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha increases expression ISO acipimox results in increased expression of IDH3A mRNA CTD PMID:25352640 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084
JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta decreases expression ISO acipimox results in decreased expression of IDH3B mRNA CTD PMID:25352640 NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982
JBrowse link
G Ins2 insulin 2 decreases expression ISO acipimox results in decreased expression of INS protein CTD PMID:8923850 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G L2hgdh L-2-hydroxyglutarate dehydrogenase decreases expression ISO acipimox results in decreased expression of L2HGDH mRNA CTD PMID:25352640 NCBI chr 6:88,164,429...88,205,585
Ensembl chr 6:88,164,440...88,205,578
JBrowse link
G Ldhb lactate dehydrogenase B increases expression ISO acipimox results in increased expression of LDHB mRNA CTD PMID:25352640 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
JBrowse link
G Mfn2 mitofusin 2 increases expression ISO acipimox results in increased expression of MFN2 mRNA CTD PMID:25352640 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO acipimox results in increased expression of COX1 mRNA; acipimox results in increased expression of COX1 protein CTD PMID:25352640 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II increases expression ISO acipimox results in increased expression of COX2 mRNA CTD PMID:25352640 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mt-nd6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 decreases expression ISO acipimox results in decreased expression of ND6 mRNA CTD PMID:25352640 NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061
JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 decreases expression ISO acipimox results in decreased expression of NDUFA1 mRNA CTD PMID:25352640 NCBI chr  X:116,424,223...116,427,875
Ensembl chr  X:116,424,223...116,428,633
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 increases expression ISO acipimox results in increased expression of NDUFA2 mRNA CTD PMID:25352640 NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076
JBrowse link
G Ndufb1 NADH:ubiquinone oxidoreductase subunit B1 decreases expression ISO acipimox results in decreased expression of NDUFB1 mRNA CTD PMID:25352640 NCBI chr 6:121,115,649...121,124,056 JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 decreases expression ISO acipimox results in decreased expression of NDUFV1 mRNA CTD PMID:25352640 NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466
JBrowse link
G Ogdh oxoglutarate dehydrogenase decreases expression ISO acipimox results in decreased expression of OGDH mRNA CTD PMID:25352640 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO acipimox results in decreased expression of PDK1 mRNA CTD PMID:25352640 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 increases expression ISO acipimox results in increased expression of PDP2 mRNA CTD PMID:25352640 NCBI chr19:386,408...394,068
Ensembl chr19:386,406...394,074
JBrowse link
G Pdpr pyruvate dehydrogenase phosphatase regulatory subunit increases expression ISO acipimox results in increased expression of PDPR mRNA CTD PMID:25352640 NCBI chr19:39,065,226...39,109,695
Ensembl chr19:39,065,157...39,109,688
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO acipimox results in increased expression of PPARA mRNA CTD PMID:25352640 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO acipimox results in increased expression of PPARGC1A mRNA CTD PMID:25352640 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Slc16a3 solute carrier family 16 member 3 increases expression ISO acipimox results in increased expression of SLC16A3 mRNA CTD PMID:25352640 NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO acipimox results in increased expression of SOD2 mRNA CTD PMID:25352640 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sod3 superoxide dismutase 3 increases expression ISO acipimox results in increased expression of SOD3 mRNA CTD PMID:25352640 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta decreases expression ISO acipimox results in decreased expression of SUCLG2 mRNA CTD PMID:25352640 NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO acipimox results in increased expression of TFAM mRNA CTD PMID:25352640 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Tnnt1 troponin T1, slow skeletal type increases expression ISO acipimox results in increased expression of TNNT1 mRNA CTD PMID:25352640 NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721
JBrowse link
G Ucp2 uncoupling protein 2 increases expression ISO acipimox results in increased expression of UCP2 mRNA CTD PMID:25352640 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Ucp3 uncoupling protein 3 decreases expression
multiple interactions
ISO acipimox results in decreased expression of UCP3 mRNA
[Albuterol co-treated with acipimox] results in decreased expression of UCP3 mRNA
CTD PMID:12824081 PMID:25352640 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein increases expression ISO acipimox results in increased expression of UQCRH mRNA CTD PMID:25352640 NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242
JBrowse link
pyrazine-2-carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acmsd aminocarboxymuconate semialdehyde decarboxylase decreases activity EXP pyrazinoic acid metabolite results in decreased activity of ACMSD protein CTD PMID:12224625 NCBI chr13:39,200,486...39,244,337
Ensembl chr13:39,200,314...39,245,209
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions EXP
ISO
pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:14747372 PMID:21074513 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO pyrazinoic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] CTD PMID:12472777 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      chemical role 19320
        donor 18633
          Bronsted acid 18516
            oxoacid 18472
              carbon oxoacid 18351
                carboxylic acid 18346
                  pyrazinecarboxylic acid 41
                    3-(\{cis-4-[(2-\{[2-(acetylamino)ethyl]disulfanyl\}ethyl)carbamoyl]cyclohexyl\}carbamoyl)pyrazine-2-carboxylic acid 0
                    5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid 38
                    6-methyl-1-oxido-pyrazin-1-ium-2-carboxylic acid 0
                    pyrazine-2-carboxylic acid 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        pyrazinecarboxylic acid 41
                                          3-(\{cis-4-[(2-\{[2-(acetylamino)ethyl]disulfanyl\}ethyl)carbamoyl]cyclohexyl\}carbamoyl)pyrazine-2-carboxylic acid 0
                                          5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid 38
                                          6-methyl-1-oxido-pyrazin-1-ium-2-carboxylic acid 0
                                          pyrazine-2-carboxylic acid 3
paths to the root