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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine
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Accession:CHEBI:48339 term browser browse the term
Definition:A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Synonyms:related_synonym: Formula=C26H28Cl2N4O4;   InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3;   InChIKey=XMAYWYJOQHXEEK-UHFFFAOYSA-N;   SMILES=CC(=O)N1CCN(CC1)c1ccc(OCC2COC(Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1
 xref: Beilstein:634785;   DrugBank:DB01026;   LINCS:LSM-5148

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ketoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression EXP Ketoconazole results in decreased expression of A2M mRNA CTD PMID:18289764 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
Ensembl chr 4:154,309,426...154,359,137 		JBrowse link
G Aadat aminoadipate aminotransferase affects expression EXP Ketoconazole affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702 		JBrowse link
G Aatf apoptosis antagonizing transcription factor decreases expression EXP Ketoconazole results in decreased expression of AATF mRNA CTD PMID:25787151 NCBI chr10:71,744,648...71,837,851
Ensembl chr10:71,744,659...71,837,851 		JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions EXP Ketoconazole inhibits the reaction [Clofibrate results in increased expression of ABCA1 mRNA] CTD PMID:14690017 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO [Ketoconazole results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Ketoconazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] CTD PMID:20147439 PMID:20829430 PMID:23956101 PMID:24014644 PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
affects expression
decreases expression
decreases activity		 ISO
EXP		 ABCB1 protein results in increased transport of Ketoconazole
Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCB1A mRNA]
Ketoconazole affects the expression of ABCB1 mRNA
Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 protein]
Ketoconazole results in decreased expression of ABCB1 mRNA
Ketoconazole results in decreased activity of ABCB1 protein
[Ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; Ketoconazole binds to and results in decreased activity of ABCB1 protein; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Glucosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Lactosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCB1 mRNA]		 CTD PMID:10350002 PMID:12235267 PMID:14662772 PMID:15969931 PMID:16819505 PMID:17365992 PMID:18355885 PMID:19070657 PMID:20624464 PMID:21459122 PMID:23707768 PMID:23976943 PMID:25542144 PMID:25844889 PMID:32185415 PMID:33766574 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity
multiple interactions		 ISO
EXP		 Ketoconazole results in decreased activity of ABCB4 protein
[Chenodeoxycholic Acid co-treated with Ketoconazole] results in increased expression of ABCB4 mRNA		 CTD PMID:28437613 PMID:30985903 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCC1 mRNA] CTD PMID:33766574 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
multiple interactions		 ISO
EXP		 Ketoconazole results in decreased activity of ABCC2 protein
Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCC2 mRNA]		 CTD PMID:19070657 PMID:19766108 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCG2 mRNA] CTD PMID:32185415 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases expression ISO Ketoconazole results in increased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016 		JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 decreases expression EXP Ketoconazole results in decreased expression of ACSM1 mRNA CTD PMID:28263823 NCBI chr 1:189,359,374...189,395,277
Ensembl chr 1:189,289,957...189,395,276 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 affects expression EXP Ketoconazole affects the expression of ADAM9 mRNA CTD PMID:25787151 NCBI chr16:71,810,377...71,887,926
Ensembl chr16:71,810,377...71,887,926 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression
increases activity		 ISO
EXP		 AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 protein]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]
Ketoconazole results in increased expression of AHR mRNA
Ketoconazole results in increased activity of AHR protein
[Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; Ketoconazole results in increased activity of and results in increased localization of AHR protein
Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein]		 CTD PMID:17505019 PMID:17923278 PMID:21753779 PMID:25000292 PMID:31168027 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions
increases expression		 EXP [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of AHRR mRNA
Ketoconazole results in increased expression of AHRR mRNA		 CTD PMID:31168027 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects expression EXP Ketoconazole affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 affects expression EXP Ketoconazole affects the expression of ALDH1A4 mRNA CTD PMID:18355885 NCBI chr 1:240,584,233...240,601,843
Ensembl chr 1:240,562,423...240,601,744 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO Ketoconazole inhibits the reaction [Calcifediol results in increased expression of ALPL mRNA] CTD PMID:21542014 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537 		JBrowse link
G Amh anti-Mullerian hormone increases expression ISO Ketoconazole results in increased expression of AMH protein CTD PMID:16684832 NCBI chr 7:11,775,155...11,777,503
Ensembl chr 7:11,775,155...11,777,503 		JBrowse link
G Anxa1 annexin A1 decreases expression EXP Ketoconazole results in decreased expression of ANXA1 mRNA CTD PMID:25787151 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012 		JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Ketoconazole results in decreased expression of AP1S1 mRNA CTD PMID:17175557 NCBI chr12:22,665,128...22,676,079
Ensembl chr12:22,665,112...22,676,075 		JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP Ketoconazole affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376 		JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
increases activity
decreases activity		 ISO
EXP		 [Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of AR protein; Ketoconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; Ketoconazole inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AR protein]
Ketoconazole results in decreased expression of AR protein
Ketoconazole results in increased activity of AR protein
Ketoconazole results in decreased activity of AR protein		 CTD PMID:11118046 PMID:18324785 PMID:19226368 PMID:19587329 PMID:24323034 PMID:26867867 PMID:29162470 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Ketoconazole results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163 		JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein] CTD PMID:12164941 NCBI chr 7:141,882,261...141,924,790
Ensembl chr 7:141,882,251...141,924,788 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression EXP Ketoconazole results in increased expression of BAD mRNA CTD PMID:25787151 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; Ketoconazole inhibits the reaction [Calcifediol results in decreased expression of BAX mRNA] CTD PMID:21542014 PMID:31629065 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; Ketoconazole inhibits the reaction [Calcifediol results in increased expression of BCL2 mRNA] CTD PMID:21542014 PMID:31629065 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l11 BCL2 like 11 increases expression ISO Ketoconazole results in increased expression of BCL2L11 mRNA CTD PMID:25808816 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase affects expression EXP Ketoconazole affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO Ketoconazole results in increased expression of BID mRNA CTD PMID:25808816 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO Ketoconazole inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]] CTD PMID:31843813 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318 		JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO Ketoconazole results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820 		JBrowse link
G Bnip1 BCL2 interacting protein 1 increases expression ISO Ketoconazole results in increased expression of BNIP1 mRNA CTD PMID:25808816 NCBI chr10:16,677,077...16,689,321
Ensembl chr10:16,677,077...16,689,321 		JBrowse link
G Bnip2 BCL2 interacting protein 2 increases expression EXP Ketoconazole results in increased expression of BNIP2 mRNA CTD PMID:25808816 NCBI chr 8:76,400,333...76,426,307
Ensembl chr 8:76,400,341...76,426,503 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Ketoconazole results in increased expression of BNIP3 mRNA CTD PMID:25808816 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Casp12 caspase 12 increases expression ISO Ketoconazole results in increased expression of CASP12 mRNA CTD PMID:25808816 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO Ketoconazole results in increased activity of CASP3 protein
Ketoconazole inhibits the reaction [Galactosamine results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Ketoconazole results in increased activity of CASP3 protein]		 CTD PMID:17936189 PMID:19631732 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp6 caspase 6 decreases expression
increases expression		 EXP Ketoconazole results in decreased expression of CASP6 mRNA
Ketoconazole results in increased expression of CASP6 mRNA		 CTD PMID:25787151 PMID:25808816 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967 		JBrowse link
G Casp7 caspase 7 increases expression EXP Ketoconazole results in increased expression of CASP7 mRNA CTD PMID:25808816 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp9 caspase 9 increases expression ISO Ketoconazole results in increased expression of CASP9 mRNA CTD PMID:25808816 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase decreases expression EXP Ketoconazole results in decreased expression of CAT mRNA CTD PMID:25787151 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] CTD PMID:16784723 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl27 C-C motif chemokine ligand 27 multiple interactions ISO Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]] CTD PMID:16784723 NCBI chr 5:58,159,066...58,166,182
Ensembl chr 5:58,159,066...58,163,584 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]] CTD PMID:16784723 PMID:23688403 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Ccng1 cyclin G1 increases expression EXP Ketoconazole results in increased expression of CCNG1 mRNA CTD PMID:18289764 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325 		JBrowse link
G Cd247 Cd247 molecule multiple interactions ISO Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr13:83,996,045...84,071,408
Ensembl chr13:83,996,080...84,071,400 		JBrowse link
G Cd28 Cd28 molecule multiple interactions ISO Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871 		JBrowse link
G Cd3d CD3d molecule multiple interactions ISO Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 8:49,282,502...49,287,095
Ensembl chr 8:49,282,460...49,287,110 		JBrowse link
G Cd3e CD3e molecule multiple interactions ISO Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 8:49,297,604...49,309,370
Ensembl chr 8:49,297,608...49,308,806 		JBrowse link
G Cd3g CD3g molecule multiple interactions ISO Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 8:49,274,553...49,280,943
Ensembl chr 8:49,274,960...49,280,901 		JBrowse link
G Cdc42ep3 CDC42 effector protein 3 increases expression EXP Ketoconazole results in increased expression of CDC42EP3 mRNA CTD PMID:28263823 NCBI chr 6:1,922,500...1,942,972
Ensembl chr 6:1,922,500...1,942,972 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO
EXP		 Ketoconazole results in increased expression of CDKN1A mRNA CTD PMID:16483768 PMID:25808816 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP Ketoconazole results in increased expression of CDKN1B mRNA CTD PMID:25808816 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression EXP Ketoconazole affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886 		JBrowse link
G Ces2h carboxylesterase 2H affects expression EXP Ketoconazole affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156 		JBrowse link
G Cga glycoprotein hormones, alpha polypeptide decreases expression ISO Ketoconazole results in decreased expression of CGA mRNA CTD PMID:25808816 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367 		JBrowse link
G Clmn calmin multiple interactions ISO Ketoconazole promotes the reaction [Calcitriol results in increased expression of CLMN mRNA] CTD PMID:26485663 NCBI chr 6:128,473,592...128,567,267
Ensembl chr 6:128,473,570...128,567,198 		JBrowse link
G Clu clusterin affects expression
decreases expression		 EXP Ketoconazole affects the expression of CLU mRNA
Ketoconazole results in decreased expression of CLU mRNA		 CTD PMID:17558187 PMID:18289764 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857 		JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 affects expression EXP Ketoconazole affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 8:122,789,208...122,807,560
Ensembl chr 8:122,789,453...122,807,560 		JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 affects expression EXP Ketoconazole affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr10:3,655,038...3,774,887
Ensembl chr10:3,655,038...3,774,884 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO
EXP		 Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]
Ketoconazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of CREB1 protein]; Ketoconazole inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]		 CTD PMID:12164941 PMID:17680988 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Crem cAMP responsive element modulator affects expression EXP Ketoconazole affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888 		JBrowse link
G Ctss cathepsin S affects expression EXP Ketoconazole affects the expression of CTSS mRNA CTD PMID:18289764 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Ketoconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; Ketoconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 protein] CTD PMID:24471457 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Cycs cytochrome c, somatic decreases expression EXP Ketoconazole results in decreased expression of CYCS mRNA CTD PMID:25787151 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyct cytochrome c, testis increases expression EXP Ketoconazole results in increased expression of CYCT mRNA CTD PMID:25787151 NCBI chr 3:63,204,779...63,211,847
Ensembl chr 3:62,818,502...63,211,845 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression EXP Ketoconazole results in increased expression of CYP11A1 mRNA CTD PMID:26610754 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases activity
multiple interactions		 ISO Ketoconazole results in decreased activity of CYP11B1 protein
Ketoconazole binds to and results in decreased activity of CYP11B1 protein		 CTD PMID:15743198 PMID:31982514 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases activity
multiple interactions
increases expression		 ISO Ketoconazole results in decreased activity of CYP11B2 protein
Ketoconazole binds to and results in decreased activity of CYP11B2 protein; Ketoconazole promotes the reaction [Colforsin results in increased expression of CYP11B2 mRNA]
Ketoconazole results in increased expression of CYP11B2 mRNA		 CTD PMID:15743198 PMID:16935330 PMID:31982514 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity
decreases expression
multiple interactions		 ISO
EXP		 Ketoconazole results in decreased activity of CYP17A1 protein
Ketoconazole results in decreased expression of CYP17A1 mRNA
Ketoconazole inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]		 CTD PMID:11118046 PMID:15743198 PMID:15771425 PMID:15934942 PMID:16935330 PMID:25993309 PMID:31330226 PMID:31982514 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity
multiple interactions
decreases activity		 ISO Ketoconazole results in increased activity of CYP19A1 protein
[Ketoconazole results in increased activity of CYP19A1 protein] which results in increased chemical synthesis of Estrone; [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased metabolism of Androstenedione
Ketoconazole results in decreased activity of CYP19A1 protein		 CTD PMID:20087668 PMID:27159630 PMID:31330226 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
increases expression
multiple interactions
decreases activity		 ISO
EXP		 Ketoconazole results in increased activity of CYP1A1 protein
Ketoconazole results in increased expression of CYP1A1 mRNA
Ketoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 protein
Ketoconazole results in increased expression of CYP1A1 mRNA; Ketoconazole results in increased expression of CYP1A1 protein
Ketoconazole results in decreased activity of CYP1A1 protein
[Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of CYP1A1 mRNA]; Ketoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 protein
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of CYP1A1 mRNA; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]		 CTD PMID:14709627 PMID:17283379 PMID:18420780 PMID:18493746 PMID:19070657 PMID:21753779 PMID:25000292 PMID:26886340 PMID:31168027 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
decreases activity		 ISO
EXP		 Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines]
Ketoconazole results in increased expression of CYP1A2 mRNA; Ketoconazole results in increased expression of CYP1A2 protein
Ketoconazole results in decreased activity of CYP1A2 protein
Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin]
Ketoconazole inhibits the reaction [CYP1A2 protein results in increased oxidation of Uroporphyrinogens]		 CTD PMID:1567206 PMID:9305587 PMID:12814958 PMID:15618748 PMID:15879494 PMID:15916432 PMID:18420780 PMID:19858067 PMID:24120545 PMID:25000292 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Ketoconazole results in decreased activity of CYP1B1 protein CTD PMID:14709627 PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions
decreases activity		 EXP
ISO		 [Ketoconazole co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA; Ketoconazole inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein]
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]
[Ketoconazole results in decreased metabolism of alfacalcidol] which results in decreased expression of CYP24A1 mRNA; [Ketoconazole results in decreased metabolism of Calcitriol] which results in increased expression of CYP24A1 mRNA; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]
Ketoconazole results in decreased activity of CYP24A1 protein		 CTD PMID:16483768 PMID:16824767 PMID:18840526 PMID:20206692 PMID:26485663 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases response to substance
increases expression
decreases activity
multiple interactions		 ISO
EXP		 Ketoconazole results in decreased susceptibility to CYP26A1 protein
Ketoconazole results in increased expression of CYP26A1 mRNA
Ketoconazole results in decreased activity of CYP26A1; Ketoconazole results in decreased activity of CYP26A1 protein
[[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-hydroxyretinoic acid; [[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-hydroxyretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-hydroxyretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNF protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNFSF10 protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of and results in decreased susceptibility to Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 results in increased metabolism of Tretinoin]		 CTD PMID:12091498 PMID:14532297 PMID:15703382 PMID:18059332 PMID:21906690 PMID:25492813 PMID:28263823 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729 		JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 multiple interactions
decreases activity		 ISO Ketoconazole inhibits the reaction [CYP26B1 protein results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26B1 results in increased metabolism of Tretinoin]
Ketoconazole results in decreased activity of CYP26B1		 CTD PMID:14532297 PMID:21906690 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615 		JBrowse link
G Cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 multiple interactions ISO Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of alitretinoin]; Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of Tretinoin] CTD PMID:21906690 NCBI chr 1:256,369,410...256,380,649
Ensembl chr 1:256,370,850...256,378,335 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 decreases activity EXP Ketoconazole results in decreased activity of CYP27B1 protein CTD PMID:16483768 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects expression
decreases activity
increases expression		 EXP Ketoconazole affects the expression of CYP2A1 mRNA
Ketoconazole results in decreased activity of CYP2A1 protein
Ketoconazole results in increased expression of CYP2A1 protein		 CTD PMID:7986207 PMID:15879494 PMID:18355885 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 multiple interactions EXP Ketoconazole inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline] CTD PMID:19858067 NCBI chr 1:83,744,229...83,766,490
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression ISO Ketoconazole results in increased expression of CYP2A5 mRNA; Ketoconazole results in increased expression of CYP2A5 protein CTD PMID:17966066 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
decreases activity		 EXP
ISO		 Ketoconazole inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin]
Ketoconazole results in increased expression of CYP2B10 mRNA
Ketoconazole results in decreased activity of CYP2B10 protein		 CTD PMID:17966066 PMID:18420780 PMID:19858067 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 affects expression EXP Ketoconazole affects the expression of CYP2B15 mRNA CTD PMID:18355885 NCBI chr 1:251,325,923...251,338,404
Ensembl chr 1:251,325,923...251,338,358 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
multiple interactions		 ISO Ketoconazole results in decreased activity of CYP2B6 protein
Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]		 CTD PMID:14709627 PMID:16608920 PMID:17438109 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions
decreases activity		 EXP Ketoconazole inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
Ketoconazole results in decreased activity of CYP2C11 protein		 CTD PMID:15879494 PMID:19858067 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity		 EXP
ISO		 Ketoconazole inhibits the reaction [CYP2C6V1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
Ketoconazole results in decreased activity of CYP2C19 protein
Ketoconazole results in decreased activity of CYP2C6V1 protein		 CTD PMID:12814958 PMID:14709627 PMID:15618748 PMID:15879494 PMID:19858067 PMID:24120545 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity
multiple interactions		 ISO Ketoconazole results in decreased activity of CYP2C8 protein
Ketoconazole results in decreased activity of CYP2C29 protein
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]		 CTD PMID:14709627 PMID:15601807 PMID:18420780 PMID:24120545 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 multiple interactions EXP Ketoconazole inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin] CTD PMID:19858067 NCBI chr 7:123,651,827...123,655,896
Ensembl chr 7:123,651,827...123,655,896 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases expression
decreases activity		 ISO Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758]
Ketoconazole results in decreased expression of CYP2D22 mRNA; Ketoconazole results in decreased expression of CYP2D22 protein
Ketoconazole results in decreased activity of CYP2D22 protein; Ketoconazole results in decreased activity of CYP2D6 protein
Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan]; Ketoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 mRNA]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 protein]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein]; Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]; Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 protein]		 CTD PMID:15618748 PMID:16595712 PMID:18420780 PMID:19230594 PMID:19594327 PMID:22334051 PMID:24120545 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Ketoconazole results in decreased activity of CYP2E1 protein CTD PMID:15618748 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Ketoconazole results in decreased activity of CYP2J2 protein CTD PMID:12851038 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity		 EXP Ketoconazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of CYP3A2 protein]
Ketoconazole results in decreased activity of CYP3A2 protein; Ketoconazole results in decreased activity of CYP3A4 protein		 CTD PMID:12814958 PMID:15879494 PMID:19226368 PMID:19858067 PMID:31870919 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
decreases activity
affects expression		 EXP Ketoconazole inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline]; Ketoconazole inhibits the reaction [Genistein results in increased expression of CYP3A23-3A1 mRNA]
Ketoconazole results in decreased activity of CYP3A23-3A1 protein
Ketoconazole affects the expression of CYP3A23-3A1 mRNA		 CTD PMID:12814958 PMID:15879494 PMID:18355885 PMID:19858067 PMID:32185415 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
affects response to substance
decreases activity		 ISO CYP3A5 gene polymorphism affects the reaction [Ketoconazole results in decreased metabolism of Tacrolimus]; Ketoconazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Budesonide results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [flunisolide results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Fluticasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Triamcinolone Acetonide results in increased expression of CYP3A5 mRNA]
CYP3A5 gene polymorphism affects the susceptibility to Ketoconazole
Ketoconazole results in decreased activity of CYP3A2 protein; Ketoconazole results in decreased activity of CYP3A5 protein		 CTD PMID:12814958 PMID:15557344 PMID:15731592 PMID:19384264 PMID:24555085 PMID:26302866 PMID:31102695 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases activity ISO Ketoconazole results in decreased activity of CYP4F12 protein CTD PMID:14709627 NCBI chr 7:15,179,472...15,191,113
Ensembl chr 7:15,179,467...15,190,796 		JBrowse link
G Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 affects expression EXP Ketoconazole affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr 7:14,891,062...14,907,250
Ensembl chr 7:14,891,001...14,907,305 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity
increases expression
decreases response to substance
multiple interactions
increases activity		 ISO
EXP		 Ketoconazole results in decreased activity of CYP51A1 protein
Ketoconazole results in increased expression of CYP51 mRNA
CYP51A1 gene results in decreased susceptibility to Ketoconazole
[Ketoconazole results in increased activity of CYP51 protein] which results in increased abundance of Lanosterol
CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of Lanosterol]
Ketoconazole results in increased expression of CYP51 mRNA; Ketoconazole results in increased expression of CYP51 protein		 CTD PMID:12617470 PMID:16989930 PMID:17966066 PMID:18694951 PMID:28263823 PMID:29337257 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP [Chenodeoxycholic Acid co-treated with Ketoconazole] results in decreased expression of CYP7A1 mRNA CTD PMID:30985903 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 affects expression EXP Ketoconazole affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr13:90,532,153...90,587,542
Ensembl chr13:90,532,326...90,591,796 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO Ketoconazole results in increased expression of DDIT3 mRNA
EIF2S1 protein mutant form inhibits the reaction [Ketoconazole results in increased expression of DDIT3 mRNA]		 CTD PMID:16330322 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Depp1 DEPP1, autophagy regulator decreases expression
increases expression		 ISO Ketoconazole results in decreased expression of DEPP1 mRNA
Ketoconazole results in increased expression of DEPP1 mRNA		 CTD PMID:15342952 PMID:17175557 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression EXP Ketoconazole results in increased expression of DHCR7 mRNA CTD PMID:28263823 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904 		JBrowse link
G Dmc1 DNA meiotic recombinase 1 increases expression ISO Ketoconazole results in increased expression of DMC1 mRNA CTD PMID:16574651 NCBI chr 7:120,796,217...120,840,524
Ensembl chr 7:120,796,217...120,839,577 		JBrowse link
G Drd4 dopamine receptor D4 decreases expression
multiple interactions		 ISO Ketoconazole results in decreased expression of DRD4 mRNA
Ketoconazole inhibits the reaction [FSHB protein results in increased expression of DRD4 mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of DRD4 mRNA]		 CTD PMID:19587329 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression EXP Ketoconazole results in increased expression of DUSP1 mRNA CTD PMID:25787151 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418 		JBrowse link
G Egf epidermal growth factor increases uptake
multiple interactions		 ISO Ketoconazole results in increased uptake of EGF protein
Ketoconazole inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein]		 CTD PMID:23125191 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Ketoconazole inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein] CTD PMID:23125191 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Ketoconazole inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2AK3 protein] CTD PMID:16330322 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO EIF2S1 protein mutant form inhibits the reaction [Ketoconazole results in increased expression of DDIT3 mRNA]; EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of IDI1 mRNA]; EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of MSMO1 mRNA] CTD PMID:16330322 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Eif4b eukaryotic translation initiation factor 4B affects expression EXP Ketoconazole affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr 7:143,679,656...143,701,452
Ensembl chr 7:143,679,617...143,701,452 		JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression EXP Ketoconazole affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G Epo erythropoietin multiple interactions ISO Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]; Ketoconazole inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] CTD PMID:21566342 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266 		JBrowse link
G Eppin epididymal peptidase inhibitor multiple interactions
decreases expression		 ISO Ketoconazole inhibits the reaction [FSHB protein results in increased expression of EPPIN mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of EPPIN mRNA] CTD PMID:19587329 NCBI chr 3:161,043,761...161,050,550
Ensembl chr 3:161,041,727...161,050,557 		JBrowse link
G Ereg epiregulin increases expression ISO Ketoconazole results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression EXP Ketoconazole affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Ketoconazole results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Ketoconazole results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954 		JBrowse link
G Faf1 Fas associated factor 1 increases expression ISO
EXP		 Ketoconazole results in increased expression of FAF1 mRNA CTD PMID:25808816 NCBI chr 5:129,370,767...129,738,393
Ensembl chr 5:129,448,879...129,738,252 		JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions		 ISO
EXP		 Ketoconazole results in increased expression of FAS mRNA
Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]]		 CTD PMID:15703382 PMID:25808816 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP Ketoconazole results in increased expression of FDFT1 mRNA CTD PMID:28263823 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302 		JBrowse link
G Fgfbp3 fibroblast growth factor binding protein 3 increases expression EXP Ketoconazole results in increased expression of FGFBP3 mRNA CTD PMID:28263823 NCBI chr 1:255,555,050...255,557,055
Ensembl chr 1:255,555,050...255,557,055 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Ketoconazole results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 6:26,387,284...26,389,524 JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit decreases expression EXP Ketoconazole results in decreased expression of FOSL1 mRNA CTD PMID:25787151 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Ketoconazole inhibits the reaction [FSHB protein results in increased expression of DRD4 mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of EPPIN mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of GPD1 mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of RHOX5 mRNA] CTD PMID:19587329 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 affects expression EXP Ketoconazole affects the expression of G6PC1 mRNA CTD PMID:18289764 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO Ketoconazole results in increased expression of G6PD mRNA CTD PMID:25399406 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Ketoconazole results in increased expression of GADD45A mRNA CTD PMID:16483768 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Gckr glucokinase regulator affects expression EXP Ketoconazole affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 6:26,355,296...26,385,761
Ensembl chr 6:26,355,296...26,385,761 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Ketoconazole results in increased expression of GDPD3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150 		JBrowse link
G Gls2 glutaminase 2 affects expression EXP Ketoconazole affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr 7:2,605,679...2,621,853
Ensembl chr 7:2,605,719...2,621,852 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 affects expression EXP Ketoconazole affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 multiple interactions
decreases expression		 ISO Ketoconazole inhibits the reaction [FSHB protein results in increased expression of GPD1 mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of GPD1 mRNA] CTD PMID:19587329 NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO		 Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
Ketoconazole inhibits the reaction [columbin results in increased activity of GPT protein]		 CTD PMID:31168027 PMID:32162908 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression EXP Ketoconazole results in increased expression of GPX4 mRNA CTD PMID:17679765 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154 		JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression EXP Ketoconazole affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 3:50,937,403...51,054,447
Ensembl chr 3:50,937,669...51,054,378 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions		 EXP Ketoconazole results in increased expression of GSR mRNA
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of GSR mRNA		 CTD PMID:31168027 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
decreases expression		 ISO
EXP		 Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of GSTA1 mRNA]
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Genistein results in increased expression of GSTA1 mRNA]
Ketoconazole results in decreased expression of GSTA1 mRNA		 CTD PMID:16608920 PMID:31168027 PMID:32185415 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression ISO Ketoconazole results in decreased expression of GSTA2 mRNA CTD PMID:16608920 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO Ketoconazole results in increased expression of GSTM1 protein CTD PMID:17966066 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 affects expression EXP Ketoconazole affects the expression of GSTM2 mRNA CTD PMID:18289764 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] CTD PMID:24246759 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Hal histidine ammonia lyase affects expression EXP Ketoconazole affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
decreases expression		 ISO Ketoconazole inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
Ketoconazole results in decreased expression of HAMP protein		 CTD PMID:17966066 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 decreases expression EXP Ketoconazole results in decreased expression of HAVCR1 mRNA CTD PMID:18289764 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379 		JBrowse link
G Hmgb2 high mobility group box 2 affects expression EXP Ketoconazole affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases activity
increases expression
decreases expression
decreases activity
multiple interactions		 EXP
ISO		 Ketoconazole results in increased activity of HMGCR protein
Ketoconazole results in increased expression of HMGCR mRNA
Ketoconazole results in decreased expression of HMGCR mRNA
Ketoconazole results in decreased activity of HMGCR protein
[Colforsin co-treated with Ketoconazole] results in decreased expression of HMGCR mRNA		 CTD PMID:9199277 PMID:12617470 PMID:16935330 PMID:28263823 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP Ketoconazole results in increased expression of HMGCS1 mRNA CTD PMID:28263823 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression
multiple interactions		 EXP
ISO		 Ketoconazole affects the expression of HMOX1 mRNA
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 protein; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Ketoconazole inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]		 CTD PMID:12763371 PMID:18289764 PMID:22659318 PMID:31168027 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hpn hepsin increases expression ISO Ketoconazole results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Ketoconazole results in decreased activity of HSD11B2 protein CTD PMID:10664531 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 multiple interactions ISO Ketoconazole promotes the reaction [Calcitriol results in increased expression of HSD17B2 mRNA] CTD PMID:12040012 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions
increases expression		 ISO Ketoconazole promotes the reaction [Colforsin results in increased expression of HSD17B4 mRNA]
Ketoconazole results in increased expression of HSD17B4 mRNA		 CTD PMID:16935330 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression EXP Ketoconazole results in increased expression of HSD17B7 mRNA CTD PMID:28263823 NCBI chr13:88,288,116...88,308,019
Ensembl chr13:88,288,046...88,307,988 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP Ketoconazole results in decreased expression of HSD3B1 mRNA CTD PMID:17229994
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions
decreases expression		 ISO [Colforsin co-treated with Ketoconazole] results in decreased expression of HSD3B2 mRNA
Ketoconazole results in decreased expression of HSD3B2 mRNA		 CTD PMID:16935330 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression EXP Ketoconazole results in decreased expression of HSPD1 mRNA CTD PMID:25787151 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Ibsp integrin-binding sialoprotein multiple interactions ISO Ketoconazole inhibits the reaction [Calcifediol results in increased expression of IBSP mRNA] CTD PMID:21542014 NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression
multiple interactions		 ISO
EXP		 Ketoconazole results in increased expression of IDI1 mRNA
EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of IDI1 mRNA]		 CTD PMID:16330322 PMID:28263823 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Ketoconazole results in increased expression of IGFBP1 mRNA CTD PMID:18289764 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785 		JBrowse link
G Ighe immunoglobulin heavy constant epsilon multiple interactions ISO Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA] CTD PMID:12230500 NCBI chr 6:138,066,728...138,068,606 JBrowse link
G Igkc immunoglobulin kappa constant decreases expression EXP Ketoconazole results in decreased expression of IGKC mRNA CTD PMID:18289764
G Il1a interleukin 1 alpha increases expression ISO Ketoconazole results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO
EXP		 Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA2 mRNA]
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]
Ketoconazole results in increased expression of IL1B mRNA		 CTD PMID:17966066 PMID:28138970 PMID:31168027 PMID:32816093 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 multiple interactions ISO Ketoconazole promotes the reaction [Calcitriol results in increased expression of IL1RL1 mRNA] CTD PMID:12040012 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170 		JBrowse link
G Il24 interleukin 24 increases expression ISO Ketoconazole results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849 		JBrowse link
G Il33 interleukin 33 affects expression EXP Ketoconazole affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029 		JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
decreases secretion		 ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]]; Bucladesine inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Ketoconazole inhibits the reaction [IL4 protein results in increased chemical synthesis of Cyclic AMP]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]; Ketoconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone] CTD PMID:11886533 PMID:12230500 PMID:15284827 PMID:23688403 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il5 interleukin 5 multiple interactions
decreases secretion
decreases expression		 ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein] CTD PMID:11886533 PMID:15284827 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA2 mRNA]; Ketoconazole inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]		 CTD PMID:17966066 PMID:31168027 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Ketoconazole results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169 		JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 decreases activity ISO Ketoconazole results in decreased activity of KCNA5 protein CTD PMID:9694927 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity
decreases response to substance
multiple interactions
decreases activity
affects localization		 ISO Ketoconazole affects the activity of KCNH2 protein mutant form
KCNH2 protein mutant form results in decreased susceptibility to Ketoconazole
[Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with Loratadine] results in decreased activity of KCNH2 protein; Ketoconazole binds to and results in decreased activity of KCNH2 protein; Terfenadine promotes the reaction [Ketoconazole results in decreased activity of KCNH2 protein]
Ketoconazole results in decreased activity of KCNH2; Ketoconazole results in decreased activity of KCNH2 protein
Ketoconazole affects the localization of KCNH2; Ketoconazole affects the localization of KCNH2 protein mutant form		 CTD PMID:9694927 PMID:15272206 PMID:16542653 PMID:17965736 PMID:24052561 PMID:29143966 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Klk6 kallikrein related-peptidase 6 multiple interactions ISO Ketoconazole promotes the reaction [Calcitriol results in increased expression of KLK6 mRNA] CTD PMID:26485663 NCBI chr 1:99,762,195...99,769,486
Ensembl chr 1:99,762,253...99,769,488 		JBrowse link
G Lcn2 lipocalin 2 decreases expression EXP Ketoconazole results in decreased expression of LCN2 mRNA CTD PMID:18289764 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Ketoconazole inhibits the reaction [LHB protein results in increased abundance of Testosterone] CTD PMID:7589908 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724 		JBrowse link
G Lhx1 LIM homeobox 1 increases expression EXP Ketoconazole results in increased expression of LHX1 mRNA CTD PMID:28263823 NCBI chr10:71,843,991...71,849,293
Ensembl chr10:71,843,991...71,849,293 		JBrowse link
G LOC299277 similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B increases expression ISO Ketoconazole results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:127,871,895...127,888,287
Ensembl chr 6:127,872,666...127,886,540 		JBrowse link
G Lox lysyl oxidase affects expression EXP Ketoconazole affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819 		JBrowse link
G Lrrc75a leucine rich repeat containing 75A increases expression EXP Ketoconazole results in increased expression of LRRC75A mRNA CTD PMID:28263823 NCBI chr10:48,929,519...48,947,606
Ensembl chr10:48,930,416...48,944,304 		JBrowse link
G Lss lanosterol synthase increases expression ISO Ketoconazole results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497 		JBrowse link
G Macroh2a1 macroH2A.1 histone affects expression EXP Ketoconazole affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr17:9,282,109...9,344,698
Ensembl chr17:9,282,675...9,344,678 		JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 multiple interactions ISO Ketoconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] CTD PMID:12388057 NCBI chr 7:12,918,352...12,922,509
Ensembl chr 7:12,918,710...12,922,112 		JBrowse link
G Manba mannosidase beta affects expression EXP Ketoconazole affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 2:240,668,213...240,760,264
Ensembl chr 2:240,668,195...240,760,261 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
increases expression		 ISO
EXP		 Ketoconazole results in increased phosphorylation of MAPK8 protein
Ketoconazole results in increased expression of MAPK8 mRNA		 CTD PMID:19631732 PMID:25787151 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein CTD PMID:31629065 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Ketoconazole results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665 		JBrowse link
G Mgp matrix Gla protein affects expression EXP Ketoconazole affects the expression of MGP mRNA CTD PMID:18289764 NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225 		JBrowse link
G Micb MHC class I polypeptide-related sequence B increases expression ISO Ketoconazole results in increased expression of MICB mRNA CTD PMID:32060585 NCBI chr 1:79,754,587...79,772,092
Ensembl chr 1:79,754,587...79,772,092 		JBrowse link
G Mill1 MHC I like leukocyte 1 increases expression ISO Ketoconazole results in increased expression of MICA mRNA CTD PMID:32060585 NCBI chr 1:79,631,266...79,657,943
Ensembl chr 1:79,631,668...79,657,941 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression ISO Ketoconazole results in increased expression of MKI67 mRNA CTD PMID:25808816 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Mlx MAX dimerization protein MLX affects expression EXP Ketoconazole affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr10:88,997,011...89,002,154
Ensembl chr10:88,997,399...89,002,152 		JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B affects expression EXP Ketoconazole affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr20:3,344,870...3,350,929
Ensembl chr20:3,344,870...3,350,927 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects expression
increases expression
multiple interactions		 EXP
ISO		 Ketoconazole affects the expression of MSMO1 mRNA
Ketoconazole results in increased expression of MSMO1 mRNA
EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of MSMO1 mRNA]		 CTD PMID:16330322 PMID:18355885 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973 		JBrowse link
G Mt1 metallothionein 1 increases expression EXP Ketoconazole results in increased expression of MT1A mRNA CTD PMID:18289764 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression EXP Ketoconazole results in decreased expression of NCF1 mRNA CTD PMID:25787151 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Ketoconazole inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOA1 protein]; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]] CTD PMID:12072427 PMID:16819505 PMID:17438109 PMID:17998298 PMID:23525103 PMID:23707768 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO Ketoconazole inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOR2 protein] CTD PMID:12072427 PMID:29356861 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701 		JBrowse link
G Ncr3lg1 natural killer cell cytotoxicity receptor 3 ligand 1 increases expression ISO Ketoconazole results in increased expression of NCR3LG1 mRNA; Ketoconazole results in increased expression of NCR3LG1 protein CTD PMID:32060585 NCBI chr 1:102,078,274...102,093,495 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression		 ISO
EXP		 [Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of NFE2L2 protein
Ketoconazole results in increased expression of NFE2L2 protein
Ketoconazole results in increased expression of NFE2L2 mRNA; Ketoconazole results in increased expression of NFE2L2 protein		 CTD PMID:21753779 PMID:31168027 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein] CTD PMID:23688403 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Ngfr nerve growth factor receptor increases expression EXP Ketoconazole results in increased expression of NGFR mRNA CTD PMID:28263823 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Ketoconazole results in increased expression of NLRP3 mRNA CTD PMID:28138970 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO
EXP		 Ketoconazole results in increased expression of NQO1 mRNA; Ketoconazole results in increased expression of NQO1 protein
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of NQO1 mRNA
AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 protein]; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of NQO1 mRNA]		 CTD PMID:17923278 PMID:21753779 PMID:31168027 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Ketoconazole results in increased expression of NR0B2 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO Ketoconazole inhibits the reaction [TO-901317 results in increased activity of NR1H2 protein] CTD PMID:16819505 NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions EXP
ISO		 Ketoconazole inhibits the reaction [Clofibrate results in increased expression of NR1H3 mRNA]
Ketoconazole inhibits the reaction [TO-901317 results in increased activity of NR1H3 protein]		 CTD PMID:14690017 PMID:16819505 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Ketoconazole inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:16819505 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
decreases response to substance
decreases expression
increases activity		 ISO [Ketoconazole co-treated with Rifampin] results in increased activity of NR1I2 protein; Ketoconazole binds to and results in decreased activity of NR1I2 protein; Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOA1 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOR2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein results in decreased uptake of and results in decreased metabolism of Glucose]; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased activity of NR1I2 protein]; Ketoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Ketoconazole inhibits the reaction [Rifampin binds to and results in increased activity of NR1I2 protein]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]
NR1I2 protein mutant form results in decreased susceptibility to Ketoconazole
Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein]
Ketoconazole results in decreased expression of NR1I2 mRNA; Ketoconazole results in decreased expression of NR1I2 protein
Ketoconazole results in increased activity of NR1I2 protein		 CTD PMID:12072427 PMID:16608920 PMID:16819505 PMID:17438109 PMID:17998298 PMID:20869355 PMID:21402137 PMID:23525103 PMID:23707768 PMID:25343516 PMID:25680588 PMID:26616219 PMID:29356861 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases activity
decreases expression		 ISO [Ketoconazole co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; Ketoconazole binds to and results in decreased activity of NR1I3 protein alternative form; Ketoconazole inhibits the reaction [Dexamethasone results in increased expression of NR1I3 mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased activity of NR1I3 protein]
Ketoconazole results in decreased activity of NR1I3 protein
Ketoconazole inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein]
Ketoconazole results in decreased expression of NR1I3 mRNA		 CTD PMID:16608920 PMID:16819505 PMID:20869355 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding
multiple interactions
decreases activity		 ISO Ketoconazole binds to NR3C1 protein
Ketoconazole inhibits the reaction [Dexamethasone binds to and results in increased activity of NR3C1 protein]
Ketoconazole results in decreased activity of NR3C1 protein		 CTD PMID:15755314 PMID:16608920 PMID:25000292 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Nrep neuronal regeneration related protein affects expression EXP Ketoconazole affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445 		JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like increases expression EXP Ketoconazole results in increased expression of NSDHL mRNA CTD PMID:28263823 NCBI chr  X:152,933,118...152,964,399
Ensembl chr  X:152,933,069...152,964,390 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Ketoconazole results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524 		JBrowse link
G Oaf out at first homolog affects expression EXP Ketoconazole affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr 8:47,511,718...47,529,689
Ensembl chr 8:47,511,719...47,529,689 		JBrowse link
G Ovol1 ovo like transcriptional repressor 1 increases expression ISO Ketoconazole results in increased expression of OVOL1 mRNA; Ketoconazole results in increased expression of OVOL1 protein CTD PMID:26873447 NCBI chr 1:220,927,309...220,938,814
Ensembl chr 1:220,925,605...220,938,814 		JBrowse link
G Pc pyruvate carboxylase affects expression EXP Ketoconazole affects the expression of PC mRNA CTD PMID:18355885 NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression EXP Ketoconazole results in increased expression of PCSK9 mRNA CTD PMID:28263823 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726 		JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase affects expression EXP Ketoconazole affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 9:79,601,937...79,630,547
Ensembl chr 9:79,601,901...79,630,536 		JBrowse link
G Plekha4 pleckstrin homology domain containing A4 increases expression EXP Ketoconazole results in increased expression of PLEKHA4 mRNA CTD PMID:28263823 NCBI chr 1:101,517,702...101,540,802
Ensembl chr 1:101,517,714...101,540,802 		JBrowse link
G Pmvk phosphomevalonate kinase increases expression EXP Ketoconazole results in increased expression of PMVK mRNA CTD PMID:28263823 NCBI chr 2:188,784,329...188,793,890
Ensembl chr 2:188,784,222...188,793,895 		JBrowse link
G Pomc proopiomelanocortin decreases expression ISO Ketoconazole results in decreased expression of POMC protein modified form CTD PMID:25808816 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967 		JBrowse link
G Por cytochrome p450 oxidoreductase affects expression
increases expression
multiple interactions		 EXP
ISO		 Ketoconazole affects the expression of POR mRNA
Ketoconazole results in increased expression of POR protein
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]		 CTD PMID:17966066 PMID:18355885 PMID:24120545 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Ketoconazole results in decreased expression of POU5F1 mRNA CTD PMID:16574651 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Ketoconazole inhibits the reaction [Clofibrate results in increased expression of PPARA mRNA] CTD PMID:14690017 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression EXP Ketoconazole results in decreased expression of PPP2CB mRNA CTD PMID:25787151 NCBI chr16:62,273,276...62,294,767
Ensembl chr16:62,273,276...62,294,769 		JBrowse link
G Prdx3 peroxiredoxin 3 decreases expression EXP Ketoconazole results in decreased expression of PRDX3 mRNA CTD PMID:25787151 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions
increases response to substance
increases expression		 EXP 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN protein]; tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA]; tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN protein]
PRKN protein results in increased susceptibility to Ketoconazole
Ketoconazole results in increased expression of PRKN mRNA; Ketoconazole results in increased expression of PRKN protein		 CTD PMID:25787151 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Prl prolactin decreases expression EXP Ketoconazole results in decreased expression of PRL mRNA CTD PMID:25808816 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299 		JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions
increases response to substance		 ISO PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
PTGER2 protein results in increased susceptibility to Ketoconazole		 CTD PMID:16784723 NCBI chr15:19,336,029...19,349,759
Ensembl chr15:19,338,175...19,350,210 		JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions
increases response to substance		 ISO PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
PTGER3 protein results in increased susceptibility to Ketoconazole		 CTD PMID:16784723 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein]
Ketoconazole results in increased expression of PTGS2 mRNA		 CTD PMID:12164941 PMID:32816093 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Pth parathyroid hormone multiple interactions EXP Ketoconazole inhibits the reaction [25-hydroxyvitamin D results in decreased expression of PTH mRNA] CTD PMID:18304585 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761 		JBrowse link
G Rarb retinoic acid receptor, beta increases expression EXP Ketoconazole results in increased expression of RARB mRNA CTD PMID:28263823 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression EXP Ketoconazole affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein] CTD PMID:31168027 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Ren renin decreases expression ISO Ketoconazole results in decreased expression of REN protein CTD PMID:2632720 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151 		JBrowse link
G Rnf41 ring finger protein 41 increases expression EXP Ketoconazole results in increased expression of RNF41 mRNA CTD PMID:25787151 NCBI chr 7:2,827,242...2,854,230
Ensembl chr 7:2,827,247...2,852,681 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression EXP Ketoconazole affects the expression of RT1-S3 mRNA CTD PMID:18355885 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO Ketoconazole inhibits the reaction [Calcifediol results in increased expression of RUNX2 mRNA] CTD PMID:21542014 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092 		JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP Ketoconazole results in increased expression of SC5D mRNA CTD PMID:28263823 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP Ketoconazole results in increased expression of SCD1 mRNA CTD PMID:28263823 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Sema3b semaphorin 3B multiple interactions ISO Ketoconazole promotes the reaction [Calcitriol results in increased expression of SEMA3B mRNA] CTD PMID:12040012 NCBI chr 8:116,353,791...116,362,655
Ensembl chr 8:116,354,073...116,361,343 		JBrowse link
G Serpinb1a serpin family B member 1A multiple interactions ISO Ketoconazole promotes the reaction [Calcitriol results in increased expression of SERPINB1 mRNA] CTD PMID:26485663 NCBI chr17:32,903,089...32,911,498
Ensembl chr17:32,904,119...32,911,495 		JBrowse link
G Serpinb3 serpin family B member 3 multiple interactions ISO Ketoconazole promotes the reaction [Calcitriol results in decreased expression of SERPINB3 mRNA] CTD PMID:12040012 NCBI chr13:27,186,701...27,193,211
Ensembl chr13:27,187,130...27,192,592 		JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions ISO Ketoconazole inhibits the reaction [Tunicamycin results in decreased glycosylation of SERPINH1 protein] CTD PMID:16330322 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317 		JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 affects expression EXP Ketoconazole affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr 1:144,069,641...144,200,402
Ensembl chr 1:144,069,638...144,200,397 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions EXP [Chenodeoxycholic Acid co-treated with Ketoconazole] results in decreased expression of SLC10A1 mRNA CTD PMID:30985903 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO Ketoconazole inhibits the reaction [Maneb results in decreased expression of SLC18A2 protein]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of SLC18A2 protein] CTD PMID:22334051 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Ketoconazole results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
Ensembl chr 4:155,408,233...155,631,856 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Ketoconazole inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Ketoconazole inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799 		JBrowse link
G Slc6a6 solute carrier family 6 member 6 affects expression EXP Ketoconazole affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 4:123,638,619...123,713,469
Ensembl chr 4:123,642,210...123,713,464 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Ketoconazole results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression EXP Ketoconazole affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO Ketoconazole results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433 		JBrowse link
G Sphk1 sphingosine kinase 1 increases expression EXP Ketoconazole results in increased expression of SPHK1 mRNA CTD PMID:25787151 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393 		JBrowse link
G Sqle squalene epoxidase increases expression EXP Ketoconazole results in increased expression of SQLE mRNA CTD PMID:28263823 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression EXP Ketoconazole results in increased expression of SREBF2 mRNA CTD PMID:28263823 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603 		JBrowse link
G St13 ST13, Hsp70 interacting protein affects expression EXP Ketoconazole affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO Ketoconazole results in increased expression of STAR mRNA CTD PMID:10960482 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 increases expression EXP Ketoconazole results in increased expression of STARD4 mRNA CTD PMID:28263823 NCBI chr18:25,982,210...25,997,555
Ensembl chr18:25,984,638...25,997,555 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression
multiple interactions		 EXP
ISO		 Ketoconazole results in increased expression of STAT1 mRNA
Ketoconazole inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]		 CTD PMID:24471457 PMID:25787151 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Stbd1 starch binding domain 1 affects expression EXP Ketoconazole affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr14:16,976,355...16,979,760
Ensembl chr14:16,976,356...16,979,760 		JBrowse link
G Stmn1 stathmin 1 affects expression EXP Ketoconazole affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806 		JBrowse link
G Stra8 stimulated by retinoic acid 8 increases expression ISO Ketoconazole results in increased expression of STRA8 mRNA CTD PMID:16461896 NCBI chr 4:62,447,724...62,474,802
Ensembl chr 4:62,457,694...62,473,360 		JBrowse link
G Sycp3 synaptonemal complex protein 3 increases expression ISO Ketoconazole results in increased expression of SYCP3 mRNA CTD PMID:16574651 NCBI chr 7:29,029,887...29,044,344
Ensembl chr 7:29,029,263...29,044,251 		JBrowse link
G Tagln transgelin decreases expression ISO Ketoconazole results in decreased expression of TAGLN mRNA CTD PMID:17175557 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357 		JBrowse link
G Tat tyrosine aminotransferase decreases expression ISO Ketoconazole results in decreased expression of TAT mRNA CTD PMID:16608920 PMID:25000292 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229 		JBrowse link
G Tex261 testis expressed 261 affects expression EXP Ketoconazole affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 4:115,446,830...115,454,035
Ensembl chr 4:115,448,708...115,453,659 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Ketoconazole inhibits the reaction [Maneb results in decreased expression of TH protein]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of TH protein] CTD PMID:19594327 PMID:22334051 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Timm10b translocase of inner mitochondrial membrane 10B affects expression EXP Ketoconazole affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr 1:170,471,265...170,474,111
Ensembl chr 1:170,471,238...170,474,113 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression EXP Ketoconazole results in decreased expression of TIMP1 mRNA CTD PMID:18289764 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
G Tmprss2 transmembrane serine protease 2 multiple interactions ISO [Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of TMPRSS2 protein CTD PMID:24323034 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290 		JBrowse link
G Tmsb10 thymosin, beta 10 decreases expression EXP Ketoconazole results in decreased expression of TMSB10 mRNA CTD PMID:18289764 NCBI chr 4:100,882,216...100,883,303
Ensembl chr 4:100,882,216...100,883,275 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO
EXP		 Ketoconazole results in increased expression of TNF mRNA
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
Ketoconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]
AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Ketoconazole inhibits the reaction [Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNF protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; Ketoconazole promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]		 CTD PMID:11135059 PMID:12388057 PMID:15703382 PMID:16784723 PMID:21753779 PMID:22785256 PMID:25808816 PMID:31168027 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO Ketoconazole results in increased expression of TNFRSF1A mRNA CTD PMID:25808816 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO
EXP		 Ketoconazole results in increased expression of TNFRSF1B mRNA CTD PMID:25808816 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNFSF10 protein]] CTD PMID:15703382 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899 		JBrowse link
G Tp63 tumor protein p63 decreases expression ISO Ketoconazole results in decreased expression of TRP63 mRNA CTD PMID:25808816 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501 		JBrowse link
G Tp73 tumor protein p73 decreases expression EXP Ketoconazole results in decreased expression of TP73 mRNA CTD PMID:25808816 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354 		JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361 		JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression EXP Ketoconazole affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr16:20,668,925...20,671,127
Ensembl chr16:20,668,971...20,671,127 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression
decreases expression
decreases activity
multiple interactions		 EXP
ISO		 Ketoconazole affects the expression of UGT1A1 mRNA
Ketoconazole results in decreased expression of UGT1A1 mRNA
Ketoconazole results in decreased activity of UGT1A1 protein
[Ketoconazole results in decreased activity of UGT1A1 protein] which results in decreased metabolism of irinotecan		 CTD PMID:16608920 PMID:18355885 PMID:22447115 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 affects expression EXP Ketoconazole affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr14:22,192,970...22,217,094 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 affects expression EXP Ketoconazole affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444 		JBrowse link
G Vdr vitamin D receptor multiple interactions ISO Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]; Ketoconazole inhibits the reaction [Vitamin D analog results in increased activity of VDR protein] CTD PMID:16280049 PMID:24792400 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]]; Ketoconazole inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA] CTD PMID:21566342 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vim vimentin affects expression EXP Ketoconazole affects the expression of VIM mRNA CTD PMID:18289764 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Ketoconazole results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    chemical entity 19773
      atom 19772
        nonmetal atom 19651
          oxygen atom 19356
            oxygen molecular entity 19356
              organooxygen compound 18886
                ether 16892
                  1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine 291
                    cis-1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine + 291
                    trans-1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic molecule 19502
                              organic cyclic compound 19329
                                organic heterocyclic compound 18544
                                  heteroarene 16521
                                    monocyclic heteroarene 13363
                                      azole 12537
                                        diazole 8255
                                          imidazoles 7687
                                            1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine 291
                                              cis-1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine + 291
                                              trans-1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine + 0
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