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G |
A2m |
alpha-2-macroglobulin |
decreases expression |
EXP |
Ketoconazole results in decreased expression of A2M mRNA |
CTD |
PMID:18289764 |
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NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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G |
Aadat |
aminoadipate aminotransferase |
affects expression |
EXP |
Ketoconazole affects the expression of AADAT mRNA |
CTD |
PMID:18355885 |
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NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
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G |
Aatf |
apoptosis antagonizing transcription factor |
decreases expression |
EXP |
Ketoconazole results in decreased expression of AATF mRNA |
CTD |
PMID:25787151 |
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NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [Clofibrate results in increased expression of ABCA1 mRNA] |
CTD |
PMID:14690017 |
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NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases activity |
ISO |
[Ketoconazole results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Ketoconazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] |
CTD |
PMID:20147439 PMID:20829430 PMID:23956101 PMID:24014644 PMID:28437613 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport multiple interactions affects expression decreases expression decreases activity |
ISO EXP |
ABCB1 protein results in increased transport of Ketoconazole Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCB1A mRNA] Ketoconazole affects the expression of ABCB1 mRNA Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 protein] Ketoconazole results in decreased expression of ABCB1 mRNA Ketoconazole results in decreased activity of ABCB1 protein [Ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; Ketoconazole binds to and results in decreased activity of ABCB1 protein; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Glucosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Lactosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCB1 mRNA] |
CTD |
PMID:10350002 PMID:12235267 PMID:14662772 PMID:15969931 PMID:16819505 PMID:17365992 PMID:18355885 PMID:19070657 PMID:20624464 PMID:21459122 PMID:23707768 PMID:23976943 PMID:25542144 PMID:25844889 PMID:32185415 PMID:33766574 More...
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases activity multiple interactions |
ISO EXP |
Ketoconazole results in decreased activity of ABCB4 protein [Chenodeoxycholic Acid co-treated with Ketoconazole] results in increased expression of ABCB4 mRNA |
CTD |
PMID:28437613 PMID:30985903 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCC1 mRNA] |
CTD |
PMID:33766574 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
decreases activity multiple interactions |
ISO EXP |
Ketoconazole results in decreased activity of ABCC2 protein Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCC2 mRNA] |
CTD |
PMID:19070657 PMID:19766108 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCG2 mRNA] |
CTD |
PMID:32185415 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Ace2 |
angiotensin I converting enzyme 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of ACE2 mRNA |
CTD |
PMID:32808185 |
|
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Acsm1 |
acyl-CoA synthetase medium-chain family member 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ACSM1 mRNA |
CTD |
PMID:28263823 |
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NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495
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G |
Adam9 |
ADAM metallopeptidase domain 9 |
affects expression |
EXP |
Ketoconazole affects the expression of ADAM9 mRNA |
CTD |
PMID:25787151 |
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NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions increases expression increases activity |
ISO EXP |
AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 protein]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein] Ketoconazole results in increased expression of AHR mRNA Ketoconazole results in increased activity of AHR protein [Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; Ketoconazole results in increased activity of and results in increased localization of AHR protein Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein] |
CTD |
PMID:17505019 PMID:17923278 PMID:21753779 PMID:25000292 PMID:31168027 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Ahrr |
aryl-hydrocarbon receptor repressor |
multiple interactions increases expression |
EXP |
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of AHRR mRNA Ketoconazole results in increased expression of AHRR mRNA |
CTD |
PMID:31168027 |
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NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
affects expression |
EXP |
Ketoconazole affects the expression of ALDH1A1 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldh1a7 |
aldehyde dehydrogenase family 1, subfamily A7 |
affects expression |
EXP |
Ketoconazole affects the expression of ALDH1A4 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 1:218,201,443...218,241,410
Ensembl chr 1:218,201,472...218,248,906
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of ALPL mRNA] |
CTD |
PMID:21542014 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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G |
Amh |
anti-Mullerian hormone |
increases expression |
ISO |
Ketoconazole results in increased expression of AMH protein |
CTD |
PMID:16684832 |
|
NCBI chr 7:8,906,776...8,909,184
Ensembl chr 7:8,906,836...8,909,282
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G |
Anxa1 |
annexin A1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of ANXA1 mRNA |
CTD |
PMID:25787151 |
|
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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G |
Ap1s1 |
adaptor related protein complex 1 subunit sigma 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of AP1S1 mRNA |
CTD |
PMID:17175557 |
|
NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
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G |
Apoa4 |
apolipoprotein A4 |
affects expression |
EXP |
Ketoconazole affects the expression of APOA4 mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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G |
Ar |
androgen receptor |
multiple interactions decreases expression increases activity decreases activity |
ISO EXP |
[Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of AR protein; Ketoconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; Ketoconazole inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AR protein] Ketoconazole results in decreased expression of AR protein Ketoconazole results in increased activity of AR protein Ketoconazole results in decreased activity of AR protein |
CTD |
PMID:11118046 PMID:18324785 PMID:19226368 PMID:19587329 PMID:24323034 PMID:26867867 PMID:29162470 More...
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO |
Ketoconazole results in increased expression of ASNS mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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G |
Atf1 |
activating transcription factor 1 |
multiple interactions |
ISO |
Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein] |
CTD |
PMID:12164941 |
|
NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression |
EXP |
Ketoconazole results in increased expression of BAD mRNA |
CTD |
PMID:25787151 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; Ketoconazole inhibits the reaction [Calcifediol results in decreased expression of BAX mRNA] |
CTD |
PMID:21542014 PMID:31629065 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; Ketoconazole inhibits the reaction [Calcifediol results in increased expression of BCL2 mRNA] |
CTD |
PMID:21542014 PMID:31629065 |
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NCBI chr13:22,689,783...22,853,920
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G |
Bcl2l11 |
Bcl2-like 11 |
increases expression |
ISO |
Ketoconazole results in increased expression of BCL2L11 mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Bhmt |
betaine-homocysteine S-methyltransferase |
affects expression |
EXP |
Ketoconazole affects the expression of BHMT mRNA |
CTD |
PMID:18355885 |
|
NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
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G |
Bid |
BH3 interacting domain death agonist |
increases expression |
ISO |
Ketoconazole results in increased expression of BID mRNA |
CTD |
PMID:25808816 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Bmp2 |
bone morphogenetic protein 2 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]] |
CTD |
PMID:31843813 |
|
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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G |
Bmp6 |
bone morphogenetic protein 6 |
increases expression |
ISO |
Ketoconazole results in increased expression of BMP6 mRNA |
CTD |
PMID:32816093 |
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NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
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G |
Bnip1 |
BCL2 interacting protein 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of BNIP1 mRNA |
CTD |
PMID:25808816 |
|
NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157
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G |
Bnip2 |
BCL2 interacting protein 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of BNIP2 mRNA |
CTD |
PMID:25808816 |
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NCBI chr 8:70,640,436...70,661,782
Ensembl chr 8:70,640,445...70,675,590
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G |
Bnip3 |
BCL2 interacting protein 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of BNIP3 mRNA |
CTD |
PMID:25808816 |
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NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Casp12 |
caspase 12 |
increases expression |
ISO |
Ketoconazole results in increased expression of CASP12 mRNA |
CTD |
PMID:25808816 |
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NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
Ketoconazole results in increased activity of CASP3 protein Ketoconazole inhibits the reaction [Galactosamine results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Ketoconazole results in increased activity of CASP3 protein] |
CTD |
PMID:17936189 PMID:19631732 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp6 |
caspase 6 |
decreases expression increases expression |
EXP |
Ketoconazole results in decreased expression of CASP6 mRNA Ketoconazole results in increased expression of CASP6 mRNA |
CTD |
PMID:25787151 PMID:25808816 |
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NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G |
Casp7 |
caspase 7 |
increases expression |
EXP |
Ketoconazole results in increased expression of CASP7 mRNA |
CTD |
PMID:25808816 |
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NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp9 |
caspase 9 |
increases expression |
ISO |
Ketoconazole results in increased expression of CASP9 mRNA |
CTD |
PMID:25808816 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CAT mRNA |
CTD |
PMID:25787151 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] |
CTD |
PMID:16784723 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl27 |
C-C motif chemokine ligand 27 |
multiple interactions |
ISO |
Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]] |
CTD |
PMID:16784723 |
|
NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]] |
CTD |
PMID:16784723 PMID:23688403 |
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NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
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G |
Ccng1 |
cyclin G1 |
increases expression |
EXP |
Ketoconazole results in increased expression of CCNG1 mRNA |
CTD |
PMID:18289764 |
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NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
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G |
Cd247 |
Cd247 molecule |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] |
CTD |
PMID:24792400 |
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NCBI chr13:78,043,302...78,118,437
Ensembl chr13:78,043,307...78,122,263
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G |
Cd28 |
Cd28 molecule |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] |
CTD |
PMID:24792400 |
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NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
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G |
Cd3d |
CD3 delta subunit of T-cell receptor complex |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] |
CTD |
PMID:24792400 |
|
NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809
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G |
Cd3e |
CD3 epsilon subunit of T-cell receptor complex |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] |
CTD |
PMID:24792400 |
|
NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022
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G |
Cd3g |
CD3 gamma subunit of T-cell receptor complex |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] |
CTD |
PMID:24792400 |
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NCBI chr 8:45,280,797...45,287,271
Ensembl chr 8:45,281,204...45,287,147
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G |
Cdc42ep3 |
CDC42 effector protein 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of CDC42EP3 mRNA |
CTD |
PMID:28263823 |
|
NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO EXP |
Ketoconazole results in increased expression of CDKN1A mRNA |
CTD |
PMID:16483768 PMID:25808816 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
EXP |
Ketoconazole results in increased expression of CDKN1B mRNA |
CTD |
PMID:25808816 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cdkn2c |
cyclin-dependent kinase inhibitor 2C |
affects expression |
EXP |
Ketoconazole affects the expression of CDKN2C mRNA |
CTD |
PMID:18355885 |
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NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
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G |
Ces2h |
carboxylesterase 2H |
affects expression |
EXP |
Ketoconazole affects the expression of CES2 mRNA |
CTD |
PMID:18355885 |
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NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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G |
Cga |
glycoprotein hormones, alpha polypeptide |
decreases expression |
ISO |
Ketoconazole results in decreased expression of CGA mRNA |
CTD |
PMID:25808816 |
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NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
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G |
Clmn |
calmin |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of CLMN mRNA] |
CTD |
PMID:26485663 |
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NCBI chr 6:123,707,710...123,807,283
Ensembl chr 6:123,713,507...123,807,272
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G |
Clu |
clusterin |
affects expression decreases expression |
EXP |
Ketoconazole affects the expression of CLU mRNA Ketoconazole results in decreased expression of CLU mRNA |
CTD |
PMID:17558187 PMID:18289764 |
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NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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G |
Cmtm6 |
CKLF-like MARVEL transmembrane domain containing 6 |
affects expression |
EXP |
Ketoconazole affects the expression of CMTM6 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 8:114,422,681...114,441,034
Ensembl chr 8:114,422,921...114,441,033
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G |
Cpped1 |
calcineurin-like phosphoesterase domain containing 1 |
affects expression |
EXP |
Ketoconazole affects the expression of CPPED1 mRNA |
CTD |
PMID:18355885 |
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NCBI chr10:3,701,522...3,821,050
Ensembl chr10:3,701,459...3,821,054
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO EXP |
Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein] Ketoconazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of CREB1 protein]; Ketoconazole inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:12164941 PMID:17680988 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Crem |
cAMP responsive element modulator |
affects expression |
EXP |
Ketoconazole affects the expression of CREM mRNA |
CTD |
PMID:18355885 |
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NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
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G |
Ctss |
cathepsin S |
affects expression |
EXP |
Ketoconazole affects the expression of CTSS mRNA |
CTD |
PMID:18289764 |
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NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; Ketoconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 protein] |
CTD |
PMID:24471457 |
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NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cycs |
cytochrome c, somatic |
decreases expression |
EXP |
Ketoconazole results in decreased expression of CYCS mRNA |
CTD |
PMID:25787151 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
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G |
Cyct |
cytochrome c, testis |
increases expression |
EXP |
Ketoconazole results in increased expression of CYCT mRNA |
CTD |
PMID:25787151 |
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NCBI chr 3:61,290,090...61,297,158
Ensembl chr 3:60,913,562...61,297,158
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of CYP11A1 mRNA |
CTD |
PMID:26610754 |
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NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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G |
Cyp11b2 |
cytochrome P450, family 11, subfamily b, polypeptide 2 |
multiple interactions decreases activity |
ISO |
Ketoconazole binds to and results in decreased activity of CYP11B1 protein Ketoconazole results in decreased activity of CYP11B1 protein |
CTD |
PMID:15743198 PMID:31982514 |
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NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
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G |
Cyp11b3 |
cytochrome P450, family 11, subfamily b, polypeptide 3 |
decreases activity multiple interactions increases expression |
ISO |
Ketoconazole results in decreased activity of CYP11B2 protein Ketoconazole binds to and results in decreased activity of CYP11B2 protein; Ketoconazole promotes the reaction [Colforsin results in increased expression of CYP11B2 mRNA] Ketoconazole results in increased expression of CYP11B2 mRNA |
CTD |
PMID:15743198 PMID:16935330 PMID:31982514 |
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NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases activity decreases expression multiple interactions |
ISO EXP |
Ketoconazole results in decreased activity of CYP17A1 protein Ketoconazole results in decreased expression of CYP17A1 mRNA Ketoconazole inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] |
CTD |
PMID:11118046 PMID:15743198 PMID:15771425 PMID:15934942 PMID:16935330 PMID:25993309 PMID:31330226 PMID:31982514 More...
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NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
increases activity multiple interactions decreases activity |
ISO |
Ketoconazole results in increased activity of CYP19A1 protein [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased chemical synthesis of Estrone; [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased metabolism of Androstenedione Ketoconazole results in decreased activity of CYP19A1 protein |
CTD |
PMID:20087668 PMID:27159630 PMID:31330226 |
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NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases activity increases expression multiple interactions decreases activity |
ISO EXP |
Ketoconazole results in increased activity of CYP1A1 protein Ketoconazole results in increased expression of CYP1A1 mRNA Ketoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 protein Ketoconazole results in increased expression of CYP1A1 mRNA; Ketoconazole results in increased expression of CYP1A1 protein Ketoconazole results in decreased activity of CYP1A1 protein [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of CYP1A1 mRNA]; Ketoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 protein [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of CYP1A1 mRNA; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] |
CTD |
PMID:14709627 PMID:17283379 PMID:18420780 PMID:18493746 PMID:19070657 PMID:21753779 PMID:25000292 PMID:26886340 PMID:31168027 PMID:34181028 More...
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions increases expression decreases activity |
ISO EXP |
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines] Ketoconazole results in increased expression of CYP1A2 mRNA; Ketoconazole results in increased expression of CYP1A2 protein Ketoconazole results in decreased activity of CYP1A2 protein Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin] Ketoconazole inhibits the reaction [CYP1A2 protein results in increased oxidation of Uroporphyrinogens] |
CTD |
PMID:1567206 PMID:9305587 PMID:12814958 PMID:15618748 PMID:15879494 PMID:15916432 PMID:18420780 PMID:19858067 PMID:24120545 PMID:25000292 More...
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of CYP1B1 protein |
CTD |
PMID:14709627 PMID:18420780 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp24a1 |
cytochrome P450, family 24, subfamily a, polypeptide 1 |
multiple interactions decreases activity |
EXP ISO |
[Ketoconazole co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA; Ketoconazole inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein] Ketoconazole inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] [Ketoconazole results in decreased metabolism of alfacalcidol] which results in decreased expression of CYP24A1 mRNA; [Ketoconazole results in decreased metabolism of Calcitriol] which results in increased expression of CYP24A1 mRNA; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] Ketoconazole results in decreased activity of CYP24A1 protein |
CTD |
PMID:16483768 PMID:16824767 PMID:18840526 PMID:20206692 PMID:26485663 |
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NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
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G |
Cyp26a1 |
cytochrome P450, family 26, subfamily a, polypeptide 1 |
decreases response to substance increases expression decreases activity multiple interactions |
ISO EXP |
Ketoconazole results in decreased susceptibility to CYP26A1 protein Ketoconazole results in increased expression of CYP26A1 mRNA Ketoconazole results in decreased activity of CYP26A1; Ketoconazole results in decreased activity of CYP26A1 protein [[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-hydroxyretinoic acid; [[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-hydroxyretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-hydroxyretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNF protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNFSF10 protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of and results in decreased susceptibility to Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 results in increased metabolism of Tretinoin] |
CTD |
PMID:12091498 PMID:14532297 PMID:15703382 PMID:18059332 PMID:21906690 PMID:25492813 PMID:28263823 More...
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NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
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G |
Cyp26b1 |
cytochrome P450, family 26, subfamily b, polypeptide 1 |
multiple interactions decreases activity |
ISO |
Ketoconazole inhibits the reaction [CYP26B1 protein results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26B1 results in increased metabolism of Tretinoin] Ketoconazole results in decreased activity of CYP26B1 |
CTD |
PMID:14532297 PMID:21906690 |
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NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
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G |
Cyp26c1 |
cytochrome P450, family 26, subfamily C, polypeptide 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of alitretinoin]; Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of Tretinoin] |
CTD |
PMID:21906690 |
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NCBI chr 1:235,458,961...235,468,433
Ensembl chr 1:235,459,356...235,466,842
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G |
Cyp27b1 |
cytochrome P450, family 27, subfamily b, polypeptide 1 |
decreases activity |
EXP |
Ketoconazole results in decreased activity of CYP27B1 protein |
CTD |
PMID:16483768 |
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NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
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G |
Cyp2a1 |
cytochrome P450, family 2, subfamily a, polypeptide 1 |
affects expression decreases activity increases expression |
EXP |
Ketoconazole affects the expression of CYP2A1 mRNA Ketoconazole results in decreased activity of CYP2A1 protein Ketoconazole results in increased expression of CYP2A1 protein |
CTD |
PMID:7986207 PMID:15879494 PMID:18355885 |
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NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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G |
Cyp2a2 |
cytochrome P450, family 2, subfamily a, polypeptide 2 |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline] |
CTD |
PMID:19858067 |
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NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487
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G |
Cyp2a3 |
cytochrome P450, family 2, subfamily a, polypeptide 3 |
increases expression |
ISO |
Ketoconazole results in increased expression of CYP2A5 mRNA; Ketoconazole results in increased expression of CYP2A5 protein |
CTD |
PMID:17966066 |
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NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
multiple interactions increases expression decreases activity |
EXP ISO |
Ketoconazole inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin] Ketoconazole results in increased expression of CYP2B10 mRNA Ketoconazole results in decreased activity of CYP2B10 protein |
CTD |
PMID:17966066 PMID:18420780 PMID:19858067 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b15 |
cytochrome P450, family 2, subfamily b, polypeptide 15 |
affects expression |
EXP |
Ketoconazole affects the expression of CYP2B15 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
decreases activity multiple interactions |
ISO |
Ketoconazole results in decreased activity of CYP2B6 protein Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA] |
CTD |
PMID:14709627 PMID:16608920 PMID:17438109 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
multiple interactions decreases activity |
EXP |
Ketoconazole inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin] Ketoconazole results in decreased activity of CYP2C11 protein |
CTD |
PMID:15879494 PMID:19858067 |
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NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
multiple interactions decreases activity |
EXP ISO |
Ketoconazole inhibits the reaction [CYP2C6V1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin] Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] Ketoconazole results in decreased activity of CYP2C19 protein Ketoconazole results in decreased activity of CYP2C6V1 protein |
CTD |
PMID:12814958 PMID:14709627 PMID:15618748 PMID:15879494 PMID:19858067 PMID:24120545 More...
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity multiple interactions |
ISO |
Ketoconazole results in decreased activity of CYP2C8 protein Ketoconazole results in decreased activity of CYP2C29 protein Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:14709627 PMID:15601807 PMID:18420780 PMID:24120545 |
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G |
Cyp2d2 |
cytochrome P450, family 2, subfamily d, polypeptide 2 |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin] |
CTD |
PMID:19858067 |
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NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions decreases expression decreases activity |
ISO |
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758] Ketoconazole results in decreased expression of CYP2D22 mRNA; Ketoconazole results in decreased expression of CYP2D22 protein Ketoconazole results in decreased activity of CYP2D22 protein; Ketoconazole results in decreased activity of CYP2D6 protein Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan]; Ketoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 mRNA]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 protein]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein]; Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]; Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 protein] |
CTD |
PMID:15618748 PMID:16595712 PMID:18420780 PMID:19230594 PMID:19594327 PMID:22334051 PMID:24120545 More...
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of CYP2E1 protein |
CTD |
PMID:15618748 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp2j4 |
cytochrome P450, family 2, subfamily j, polypeptide 4 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of CYP2J2 protein |
CTD |
PMID:12851038 |
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NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions decreases expression increases response to substance decreases activity increases expression increases metabolic processing |
EXP ISO |
Ketoconazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of CYP3A2 protein] Ketoconazole results in decreased expression of CYP3A4 protein CYP3A4 protein results in increased susceptibility to Ketoconazole Ketoconazole results in decreased activity of CYP3A2 protein; Ketoconazole results in decreased activity of CYP3A4 protein Ketoconazole results in increased expression of CYP3A4 mRNA CYP3A4 protein results in increased metabolism of Ketoconazole [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Testosterone; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Triazolam; Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole affects the reaction [CYP3A4 polymorphism affects the metabolism of cabozantinib]; Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of acalabrutinib]; Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of vandetanib]; Ketoconazole binds to and results in decreased activity of CYP3A4 protein; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of Hydroxytestosterones]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Corticosterone results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Endosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Mefloquine]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased abundance of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of mono-N-demethyladinazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased susceptibility to Docetaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased abundance of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 11,12-epoxy-5,8,14-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 3'-p-hydroxypaclitaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of clozapine N-oxide]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of norclozapine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Ticlopidine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased glutathionylation of dauricine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Metoprolol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of mono-N-desethylamiodarone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of nefazodone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of 8-epidiosbulbin E acetate]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of and results in decreased abundance of Quetiapine Fumarate]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Arachidonic Acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufalin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufogenin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cabozantinib]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of carbosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cinobufagin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of eldecalcitol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Felodipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Terfenadine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Triazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 2-oxo-clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of dimemorfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Paclitaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Endosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Ticlopidine]; Ketoconazole inhibits the reaction [erdafitinib results in decreased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [U 0126 affects the activity of CYP3A4 protein]; Ketoconazole results in increased expression of and results in decreased activity of CYP3A4 protein |
CTD |
PMID:9600717 PMID:10952769 PMID:10997946 PMID:11377097 PMID:11502731 PMID:12072427 PMID:12237780 PMID:12569440 PMID:12675279 PMID:12695342 PMID:12814958 PMID:15005856 PMID:15135088 PMID:15279827 PMID:15306208 PMID:15328084 PMID:15466163 PMID:15557344 PMID:15560889 PMID:15618748 PMID:15731592 PMID:15764719 PMID:15784650 PMID:15860655 PMID:15869686 PMID:15879494 PMID:15896247 PMID:15969931 PMID:16012074 PMID:16146350 PMID:16204965 PMID:16207822 PMID:16390352 PMID:16608920 PMID:16819505 PMID:16855053 PMID:17438109 PMID:17702393 PMID:17998298 PMID:18799805 PMID:18809730 PMID:18846481 PMID:19226368 PMID:19230594 PMID:19299527 PMID:19328226 PMID:19358519 PMID:19593786 PMID:19812348 PMID:19858067 PMID:20233841 PMID:20307514 PMID:20507880 PMID:20863320 PMID:21336516 PMID:21349323 PMID:21402137 PMID:21566342 PMID:21915887 PMID:22178124 PMID:22447115 PMID:22651985 PMID:22785256 PMID:23146034 PMID:23274770 PMID:23707768 PMID:23850985 PMID:23876819 PMID:24120545 PMID:24246759 PMID:24799337 PMID:24819614 PMID:25343516 PMID:25542144 PMID:26038696 PMID:26286065 PMID:26718876 PMID:27485346 PMID:27871908 PMID:28119166 PMID:28238727 PMID:28887089 PMID:29782822 PMID:30087611 PMID:31102695 PMID:31293154 PMID:31629065 PMID:31870919 PMID:33253783 PMID:33775687 PMID:34153224 PMID:34189909 PMID:34648813 More...
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
multiple interactions decreases activity affects expression |
EXP |
Ketoconazole inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline]; Ketoconazole inhibits the reaction [Genistein results in increased expression of CYP3A23-3A1 mRNA] Ketoconazole results in decreased activity of CYP3A23-3A1 protein Ketoconazole affects the expression of CYP3A23-3A1 mRNA |
CTD |
PMID:12814958 PMID:15879494 PMID:18355885 PMID:19858067 PMID:32185415 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
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Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions affects response to substance decreases activity |
ISO |
CYP3A5 gene polymorphism affects the reaction [Ketoconazole results in decreased metabolism of Tacrolimus]; Ketoconazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Budesonide results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [erdafitinib results in decreased activity of CYP3A5 protein]; Ketoconazole inhibits the reaction [flunisolide results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Fluticasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Triamcinolone Acetonide results in increased expression of CYP3A5 mRNA] CYP3A5 gene polymorphism affects the susceptibility to Ketoconazole Ketoconazole results in decreased activity of CYP3A5 protein |
CTD |
PMID:15557344 PMID:15731592 PMID:19384264 PMID:24555085 PMID:26302866 PMID:31102695 PMID:34189909 More...
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NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Cyp4f1 |
cytochrome P450, family 4, subfamily f, polypeptide 1 |
decreases activity affects expression |
ISO EXP |
Ketoconazole results in decreased activity of CYP4F12 protein Ketoconazole affects the expression of CYP4F2 mRNA |
CTD |
PMID:14709627 PMID:18355885 |
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NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
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Cyp51 |
cytochrome P450, family 51 |
decreases activity increases expression decreases response to substance multiple interactions increases activity |
ISO EXP |
Ketoconazole results in decreased activity of CYP51A1 protein Ketoconazole results in increased expression of CYP51 mRNA CYP51A1 gene results in decreased susceptibility to Ketoconazole [Ketoconazole results in increased activity of CYP51 protein] which results in increased abundance of Lanosterol CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of Lanosterol] Ketoconazole results in increased expression of CYP51 mRNA; Ketoconazole results in increased expression of CYP51 protein |
CTD |
PMID:12617470 PMID:16989930 PMID:17966066 PMID:18694951 PMID:28263823 PMID:29337257 More...
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NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
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Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
multiple interactions |
EXP |
[Chenodeoxycholic Acid co-treated with Ketoconazole] results in decreased expression of CYP7A1 mRNA |
CTD |
PMID:30985903 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Dcaf8 |
DDB1 and CUL4 associated factor 8 |
affects expression |
EXP |
Ketoconazole affects the expression of DCAF8 mRNA |
CTD |
PMID:18355885 |
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NCBI chr13:84,609,838...84,667,025
Ensembl chr13:84,610,248...84,669,726
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions |
ISO |
Ketoconazole results in increased expression of DDIT3 mRNA EIF2S1 protein mutant form inhibits the reaction [Ketoconazole results in increased expression of DDIT3 mRNA] |
CTD |
PMID:16330322 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Depp1 |
DEPP1, autophagy regulator |
decreases expression increases expression |
ISO |
Ketoconazole results in decreased expression of DEPP1 mRNA Ketoconazole results in increased expression of DEPP1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
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Dhcr7 |
7-dehydrocholesterol reductase |
increases expression |
EXP |
Ketoconazole results in increased expression of DHCR7 mRNA |
CTD |
PMID:28263823 |
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NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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G |
Dmc1 |
DNA meiotic recombinase 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of DMC1 mRNA |
CTD |
PMID:16574651 |
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NCBI chr 7:111,124,888...111,167,465
Ensembl chr 7:111,124,888...111,167,952
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Drd4 |
dopamine receptor D4 |
decreases expression multiple interactions |
ISO |
Ketoconazole results in decreased expression of DRD4 mRNA Ketoconazole inhibits the reaction [FSHB protein results in increased expression of DRD4 mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of DRD4 mRNA] |
CTD |
PMID:19587329 |
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NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
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G |
Dusp1 |
dual specificity phosphatase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of DUSP1 mRNA |
CTD |
PMID:25787151 |
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NCBI chr10:16,680,489...16,683,276
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Egf |
epidermal growth factor |
increases uptake multiple interactions |
ISO |
Ketoconazole results in increased uptake of EGF protein Ketoconazole inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein] |
CTD |
PMID:23125191 |
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NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
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Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein] |
CTD |
PMID:23125191 |
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NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:16330322 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions |
ISO |
EIF2S1 protein mutant form inhibits the reaction [Ketoconazole results in increased expression of DDIT3 mRNA]; EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of IDI1 mRNA]; EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of MSMO1 mRNA] |
CTD |
PMID:16330322 |
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NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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Eif4b |
eukaryotic translation initiation factor 4B |
affects expression |
EXP |
Ketoconazole affects the expression of EIF4B mRNA |
CTD |
PMID:18355885 |
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NCBI chr 7:133,206,637...133,228,436
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G |
Ephx1 |
epoxide hydrolase 1 |
affects expression |
EXP |
Ketoconazole affects the expression of EPHX1 mRNA |
CTD |
PMID:18355885 |
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NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
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G |
Epo |
erythropoietin |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]; Ketoconazole inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] |
CTD |
PMID:21566342 |
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NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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G |
Eppin |
epididymal peptidase inhibitor |
multiple interactions decreases expression |
ISO |
Ketoconazole inhibits the reaction [FSHB protein results in increased expression of EPPIN mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of EPPIN mRNA] |
CTD |
PMID:19587329 |
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NCBI chr 3:153,312,396...153,319,310
Ensembl chr 3:153,312,396...153,319,310
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Ereg |
epiregulin |
increases expression |
ISO |
Ketoconazole results in increased expression of EREG mRNA |
CTD |
PMID:32816093 |
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NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
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G |
Erp29 |
endoplasmic reticulum protein 29 |
affects expression |
EXP |
Ketoconazole affects the expression of ERP29 mRNA |
CTD |
PMID:18355885 |
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NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
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F3 |
coagulation factor III, tissue factor |
increases expression |
ISO |
Ketoconazole results in increased expression of F3 protein |
CTD |
PMID:25569083 |
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NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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G |
Fabp1 |
fatty acid binding protein 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of FABP1 mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 |
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NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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G |
Faf1 |
Fas associated factor 1 |
increases expression |
ISO EXP |
Ketoconazole results in increased expression of FAF1 mRNA |
CTD |
PMID:25808816 |
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NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977
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Fas |
Fas cell surface death receptor |
increases expression multiple interactions |
ISO EXP |
Ketoconazole results in increased expression of FAS mRNA Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]] |
CTD |
PMID:15703382 PMID:25808816 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fdft1 |
farnesyl diphosphate farnesyl transferase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of FDFT1 mRNA |
CTD |
PMID:28263823 |
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NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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G |
Fgfbp3 |
fibroblast growth factor binding protein 3 |
increases expression |
EXP |
Ketoconazole results in increased expression of FGFBP3 mRNA |
CTD |
PMID:28263823 |
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NCBI chr 1:234,644,023...234,646,028
Ensembl chr 1:234,644,019...234,646,547
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Fndc4 |
fibronectin type III domain containing 4 |
increases expression |
ISO |
Ketoconazole results in increased expression of FNDC4 mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 |
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NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
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Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
decreases expression |
EXP |
Ketoconazole results in decreased expression of FOSL1 mRNA |
CTD |
PMID:25787151 |
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NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [FSHB protein results in increased expression of DRD4 mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of EPPIN mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of GPD1 mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of RHOX5 mRNA] |
CTD |
PMID:19587329 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
affects expression |
EXP |
Ketoconazole affects the expression of G6PC1 mRNA |
CTD |
PMID:18289764 |
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NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases expression |
ISO |
Ketoconazole results in increased expression of G6PD mRNA |
CTD |
PMID:25399406 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
EXP |
Ketoconazole results in increased expression of GADD45A mRNA |
CTD |
PMID:16483768 |
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NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gckr |
glucokinase regulator |
affects expression |
EXP |
Ketoconazole affects the expression of GCKR mRNA |
CTD |
PMID:18355885 |
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NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
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G |
Gdpd3 |
glycerophosphodiester phosphodiesterase domain containing 3 |
increases expression |
ISO |
Ketoconazole results in increased expression of GDPD3 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
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G |
Gls2 |
glutaminase 2 |
affects expression |
EXP |
Ketoconazole affects the expression of GLS2 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 7:617,252...633,424
Ensembl chr 7:617,288...633,426
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G |
Got2 |
glutamic-oxaloacetic transaminase 2 |
affects expression |
EXP |
Ketoconazole affects the expression of GOT2 mRNA |
CTD |
PMID:18355885 |
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NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
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G |
Gpd1 |
glycerol-3-phosphate dehydrogenase 1 |
multiple interactions decreases expression |
ISO |
Ketoconazole inhibits the reaction [FSHB protein results in increased expression of GPD1 mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of GPD1 mRNA] |
CTD |
PMID:19587329 |
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NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP ISO |
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] Ketoconazole inhibits the reaction [columbin results in increased activity of GPT protein]; Ketoconazole promotes the reaction [gelsemine results in increased expression of GPT protein] |
CTD |
PMID:31168027 PMID:32162908 PMID:34627953 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx4 |
glutathione peroxidase 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of GPX4 mRNA |
CTD |
PMID:17679765 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Grb14 |
growth factor receptor bound protein 14 |
affects expression |
EXP |
Ketoconazole affects the expression of GRB14 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889
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G |
Gsr |
glutathione-disulfide reductase |
increases expression multiple interactions |
EXP |
Ketoconazole results in increased expression of GSR mRNA [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of GSR mRNA |
CTD |
PMID:31168027 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
multiple interactions decreases expression |
ISO EXP |
Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of GSTA1 mRNA] Ketoconazole inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Genistein results in increased expression of GSTA1 mRNA] Ketoconazole results in decreased expression of GSTA1 mRNA |
CTD |
PMID:16608920 PMID:31168027 PMID:32185415 |
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NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of GSTA2 mRNA |
CTD |
PMID:16608920 |
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NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of GSTM1 protein |
CTD |
PMID:17966066 |
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NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstm2 |
glutathione S-transferase mu 2 |
affects expression |
EXP |
Ketoconazole affects the expression of GSTM2 mRNA |
CTD |
PMID:18289764 |
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NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] |
CTD |
PMID:24246759 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Hal |
histidine ammonia lyase |
affects expression |
EXP |
Ketoconazole affects the expression of HAL mRNA |
CTD |
PMID:18355885 |
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NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
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G |
Hamp |
hepcidin antimicrobial peptide |
multiple interactions decreases expression |
ISO |
Ketoconazole inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA] Ketoconazole results in decreased expression of HAMP protein |
CTD |
PMID:17966066 |
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NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of HAVCR1 mRNA |
CTD |
PMID:18289764 |
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NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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G |
Hmgb2 |
high mobility group box 2 |
affects expression |
EXP |
Ketoconazole affects the expression of HMGB2 mRNA |
CTD |
PMID:18355885 |
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NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
increases activity increases expression decreases expression decreases activity multiple interactions |
EXP ISO |
Ketoconazole results in increased activity of HMGCR protein Ketoconazole results in increased expression of HMGCR mRNA Ketoconazole results in decreased expression of HMGCR mRNA Ketoconazole results in decreased activity of HMGCR protein [Colforsin co-treated with Ketoconazole] results in decreased expression of HMGCR mRNA |
CTD |
PMID:9199277 PMID:12617470 PMID:16935330 PMID:28263823 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of HMGCS1 mRNA |
CTD |
PMID:28263823 |
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NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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G |
Hmox1 |
heme oxygenase 1 |
affects expression multiple interactions |
EXP ISO |
Ketoconazole affects the expression of HMOX1 mRNA [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 protein; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA] Ketoconazole inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein] |
CTD |
PMID:12763371 PMID:18289764 PMID:22659318 PMID:31168027 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hpn |
hepsin |
increases expression |
ISO |
Ketoconazole results in increased expression of HPN mRNA |
CTD |
PMID:15342952 |
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NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
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G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of HSD11B2 protein |
CTD |
PMID:10664531 |
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NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
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G |
Hsd17b2 |
hydroxysteroid (17-beta) dehydrogenase 2 |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of HSD17B2 mRNA] |
CTD |
PMID:12040012 |
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NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
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G |
Hsd17b4 |
hydroxysteroid (17-beta) dehydrogenase 4 |
multiple interactions increases expression |
ISO |
Ketoconazole promotes the reaction [Colforsin results in increased expression of HSD17B4 mRNA] Ketoconazole results in increased expression of HSD17B4 mRNA |
CTD |
PMID:16935330 |
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NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
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G |
Hsd17b7 |
hydroxysteroid (17-beta) dehydrogenase 7 |
increases expression |
EXP |
Ketoconazole results in increased expression of HSD17B7 mRNA |
CTD |
PMID:28263823 |
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NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of HSD3B1 mRNA |
CTD |
PMID:17229994 |
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NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Hsd3b2 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 |
multiple interactions decreases expression |
ISO |
[Colforsin co-treated with Ketoconazole] results in decreased expression of HSD3B2 mRNA Ketoconazole results in decreased expression of HSD3B2 mRNA |
CTD |
PMID:16935330 |
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NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
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G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of HSPD1 mRNA |
CTD |
PMID:25787151 |
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NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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G |
Ibsp |
integrin-binding sialoprotein |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of IBSP mRNA] |
CTD |
PMID:21542014 |
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NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693
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G |
Idi1 |
isopentenyl-diphosphate delta isomerase 1 |
increases expression multiple interactions |
ISO EXP |
Ketoconazole results in increased expression of IDI1 mRNA EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of IDI1 mRNA] |
CTD |
PMID:16330322 PMID:28263823 |
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NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of IGFBP1 mRNA |
CTD |
PMID:18289764 |
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NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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G |
Ighe |
immunoglobulin heavy constant epsilon |
multiple interactions |
ISO |
Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA] |
CTD |
PMID:12230500 |
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G |
Igkc |
immunoglobulin kappa constant |
decreases expression |
EXP |
Ketoconazole results in decreased expression of IGKC mRNA |
CTD |
PMID:18289764 |
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G |
Il1a |
interleukin 1 alpha |
increases expression |
ISO |
Ketoconazole results in increased expression of IL1A mRNA |
CTD |
PMID:32816093 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO EXP |
Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA2 mRNA]; Ketoconazole promotes the reaction [gelsemine results in increased expression of IL1B protein] Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein] Ketoconazole results in increased expression of IL1B mRNA |
CTD |
PMID:17966066 PMID:28138970 PMID:31168027 PMID:32816093 PMID:34627953 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rl1 |
interleukin 1 receptor-like 1 |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of IL1RL1 mRNA] |
CTD |
PMID:12040012 |
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NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
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G |
Il24 |
interleukin 24 |
increases expression |
ISO |
Ketoconazole results in increased expression of IL24 mRNA |
CTD |
PMID:32816093 |
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NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
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G |
Il33 |
interleukin 33 |
affects expression |
EXP |
Ketoconazole affects the expression of IL33 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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G |
Il4 |
interleukin 4 |
multiple interactions decreases expression decreases secretion |
ISO |
1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]]; Bucladesine inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Ketoconazole inhibits the reaction [IL4 protein results in increased chemical synthesis of Cyclic AMP]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]; Ketoconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone] |
CTD |
PMID:11886533 PMID:12230500 PMID:15284827 PMID:23688403 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il5 |
interleukin 5 |
multiple interactions decreases secretion decreases expression |
ISO |
1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein] |
CTD |
PMID:11886533 PMID:15284827 |
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NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA2 mRNA]; Ketoconazole inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA] Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein] |
CTD |
PMID:17966066 PMID:31168027 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Inhbe |
inhibin subunit beta E |
increases expression |
ISO |
Ketoconazole results in increased expression of INHBE mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 |
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NCBI chr 7:63,177,558...63,178,983
Ensembl chr 7:63,176,219...63,179,172
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G |
Kcna5 |
potassium voltage-gated channel subfamily A member 5 |
decreases activity |
ISO |
Ketoconazole results in decreased activity of KCNA5 protein |
CTD |
PMID:9694927 |
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NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
affects activity decreases response to substance multiple interactions decreases activity affects localization |
ISO |
Ketoconazole affects the activity of KCNH2 protein mutant form KCNH2 protein mutant form results in decreased susceptibility to Ketoconazole [Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with Loratadine] results in decreased activity of KCNH2 protein; Ketoconazole binds to and results in decreased activity of KCNH2 protein; Terfenadine promotes the reaction [Ketoconazole results in decreased activity of KCNH2 protein] Ketoconazole results in decreased activity of KCNH2; Ketoconazole results in decreased activity of KCNH2 protein Ketoconazole affects the localization of KCNH2; Ketoconazole affects the localization of KCNH2 protein mutant form |
CTD |
PMID:9694927 PMID:15272206 PMID:16542653 PMID:17965736 PMID:24052561 PMID:29143966 More...
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Klk6 |
kallikrein related-peptidase 6 |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of KLK6 mRNA] |
CTD |
PMID:26485663 |
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NCBI chr 1:94,278,863...94,286,136
Ensembl chr 1:94,280,340...94,286,121
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G |
Lcn2 |
lipocalin 2 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of LCN2 mRNA |
CTD |
PMID:18289764 |
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NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [LHB protein results in increased abundance of Testosterone] |
CTD |
PMID:7589908 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Lhx1 |
LIM homeobox 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of LHX1 mRNA |
CTD |
PMID:28263823 |
|
NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617
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G |
Lox |
lysyl oxidase |
affects expression |
EXP |
Ketoconazole affects the expression of LOX mRNA |
CTD |
PMID:18355885 |
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NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
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G |
Lrrc75a |
leucine rich repeat containing 75A |
increases expression |
EXP |
Ketoconazole results in increased expression of LRRC75A mRNA |
CTD |
PMID:28263823 |
|
NCBI chr10:47,298,222...47,343,244
Ensembl chr10:47,297,288...47,343,664
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G |
Lss |
lanosterol synthase |
increases expression |
ISO |
Ketoconazole results in increased expression of LSS mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 |
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NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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G |
Macroh2a1 |
macroH2A.1 histone |
affects expression |
EXP |
Ketoconazole affects the expression of MACROH2A1 mRNA |
CTD |
PMID:18355885 |
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NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072
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G |
Madcam1 |
mucosal vascular addressin cell adhesion molecule 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] |
CTD |
PMID:12388057 |
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NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703
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G |
Manba |
mannosidase beta |
affects expression |
EXP |
Ketoconazole affects the expression of MANBA mRNA |
CTD |
PMID:18355885 |
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NCBI chr 2:223,910,432...224,002,988
Ensembl chr 2:223,910,432...224,002,983
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation increases expression |
ISO EXP |
Ketoconazole results in increased phosphorylation of MAPK8 protein Ketoconazole results in increased expression of MAPK8 mRNA |
CTD |
PMID:19631732 PMID:25787151 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
multiple interactions |
ISO |
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein |
CTD |
PMID:31629065 |
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NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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Met |
MET proto-oncogene, receptor tyrosine kinase |
increases expression |
ISO |
Ketoconazole results in increased expression of MET mRNA |
CTD |
PMID:32816093 |
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NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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Mgp |
matrix Gla protein |
affects expression |
EXP |
Ketoconazole affects the expression of MGP mRNA |
CTD |
PMID:18289764 |
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NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
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Micb |
MHC class I polypeptide-related sequence B |
increases expression |
ISO |
Ketoconazole results in increased expression of MICB mRNA |
CTD |
PMID:32060585 |
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NCBI chr 1:78,495,779...78,513,030
Ensembl chr 1:78,495,779...78,512,827
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Mill1 |
MHC I like leukocyte 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of MICA mRNA |
CTD |
PMID:32060585 |
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NCBI chr 1:78,372,138...78,398,932
Ensembl chr 1:78,372,802...78,398,930
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Mki67 |
marker of proliferation Ki-67 |
increases expression |
ISO |
Ketoconazole results in increased expression of MKI67 mRNA |
CTD |
PMID:25808816 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mlx |
MAX dimerization protein MLX |
affects expression |
EXP |
Ketoconazole affects the expression of MLX mRNA |
CTD |
PMID:18355885 |
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NCBI chr10:86,019,216...86,024,326
Ensembl chr10:86,019,588...86,032,350
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Mrps18b |
mitochondrial ribosomal protein S18B |
affects expression |
EXP |
Ketoconazole affects the expression of MRPS18B mRNA |
CTD |
PMID:18355885 |
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NCBI chr20:2,838,174...2,844,260
Ensembl chr20:2,838,030...2,844,260
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G |
Msmo1 |
methylsterol monooxygenase 1 |
affects expression increases expression multiple interactions |
EXP ISO |
Ketoconazole affects the expression of MSMO1 mRNA Ketoconazole results in increased expression of MSMO1 mRNA EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of MSMO1 mRNA] |
CTD |
PMID:16330322 PMID:18355885 |
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NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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G |
Mt1 |
metallothionein 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of MT1A mRNA |
CTD |
PMID:18289764 |
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NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
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Ncf1 |
neutrophil cytosolic factor 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of NCF1 mRNA |
CTD |
PMID:25787151 |
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NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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G |
Ncoa1 |
nuclear receptor coactivator 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOA1 protein]; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]] |
CTD |
PMID:12072427 PMID:16819505 PMID:17438109 PMID:17998298 PMID:23525103 PMID:23707768 More...
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NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
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G |
Ncor2 |
nuclear receptor co-repressor 2 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOR2 protein] |
CTD |
PMID:12072427 PMID:29356861 |
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NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319
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G |
Ncr3lg1 |
natural killer cell cytotoxicity receptor 3 ligand 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of NCR3LG1 mRNA; Ketoconazole results in increased expression of NCR3LG1 protein |
CTD |
PMID:32060585 |
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NCBI chr 1:96,565,664...96,581,825
Ensembl chr 1:96,574,455...96,580,466
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression |
ISO EXP |
[Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]] [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of NFE2L2 protein Ketoconazole results in increased expression of NFE2L2 protein Ketoconazole results in increased expression of NFE2L2 mRNA; Ketoconazole results in increased expression of NFE2L2 protein |
CTD |
PMID:21753779 PMID:31168027 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein] |
CTD |
PMID:23688403 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Ngfr |
nerve growth factor receptor |
increases expression |
EXP |
Ketoconazole results in increased expression of NGFR mRNA |
CTD |
PMID:28263823 |
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NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
increases expression |
ISO |
Ketoconazole results in increased expression of NLRP3 mRNA |
CTD |
PMID:28138970 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO EXP |
Ketoconazole results in increased expression of NQO1 mRNA; Ketoconazole results in increased expression of NQO1 protein [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of NQO1 mRNA AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 protein]; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of NQO1 mRNA] |
CTD |
PMID:17923278 PMID:21753779 PMID:31168027 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
increases expression |
ISO |
Ketoconazole results in increased expression of NR0B2 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Nr1h2 |
nuclear receptor subfamily 1, group H, member 2 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [T0901317 results in increased activity of NR1H2 protein] |
CTD |
PMID:16819505 |
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NCBI chr 1:95,041,967...95,047,377
Ensembl chr 1:95,041,967...95,047,377
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G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
multiple interactions |
EXP ISO |
Ketoconazole inhibits the reaction [Clofibrate results in increased expression of NR1H3 mRNA] Ketoconazole inhibits the reaction [T0901317 results in increased activity of NR1H3 protein] |
CTD |
PMID:14690017 PMID:16819505 |
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NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
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Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] |
CTD |
PMID:16819505 |
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NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions decreases response to substance decreases expression increases activity |
ISO |
[Ketoconazole co-treated with Rifampin] results in increased activity of NR1I2 protein; Ketoconazole binds to and results in decreased activity of NR1I2 protein; Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOA1 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOR2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein results in decreased uptake of and results in decreased metabolism of Glucose]; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased activity of NR1I2 protein]; Ketoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Ketoconazole inhibits the reaction [Rifampin binds to and results in increased activity of NR1I2 protein]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein] NR1I2 protein mutant form results in decreased susceptibility to Ketoconazole Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] Ketoconazole results in decreased expression of NR1I2 mRNA; Ketoconazole results in decreased expression of NR1I2 protein Ketoconazole results in increased activity of NR1I2 protein |
CTD |
PMID:12072427 PMID:16608920 PMID:16819505 PMID:17438109 PMID:17998298 PMID:20869355 PMID:21402137 PMID:23525103 PMID:23707768 PMID:25343516 PMID:25680588 PMID:26616219 PMID:29356861 More...
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions decreases activity decreases expression |
ISO |
[Ketoconazole co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; Ketoconazole binds to and results in decreased activity of NR1I3 protein alternative form; Ketoconazole inhibits the reaction [Dexamethasone results in increased expression of NR1I3 mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased activity of NR1I3 protein] Ketoconazole results in decreased activity of NR1I3 protein Ketoconazole inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] Ketoconazole results in decreased expression of NR1I3 mRNA |
CTD |
PMID:16608920 PMID:16819505 PMID:20869355 |
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NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
affects binding multiple interactions decreases activity |
ISO |
Ketoconazole binds to NR3C1 protein Ketoconazole inhibits the reaction [Dexamethasone binds to and results in increased activity of NR3C1 protein] Ketoconazole results in decreased activity of NR3C1 protein |
CTD |
PMID:15755314 PMID:16608920 PMID:25000292 |
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NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nrep |
neuronal regeneration related protein |
affects expression |
EXP |
Ketoconazole affects the expression of NREP mRNA |
CTD |
PMID:18355885 |
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NCBI chr18:25,017,069...25,046,564
Ensembl chr18:25,017,083...25,046,591
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G |
Nsdhl |
NAD(P) dependent steroid dehydrogenase-like |
increases expression |
EXP |
Ketoconazole results in increased expression of NSDHL mRNA |
CTD |
PMID:28263823 |
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NCBI chr X:150,775,034...150,807,161
Ensembl chr X:150,775,080...150,807,142
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Nupr1 |
nuclear protein 1, transcriptional regulator |
increases expression |
ISO |
Ketoconazole results in increased expression of NUPR1 mRNA |
CTD |
PMID:15342952 PMID:17175557 PMID:17567588 |
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NCBI chr 1:181,213,292...181,215,327
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Oaf |
out at first homolog |
affects expression |
EXP |
Ketoconazole affects the expression of OAF mRNA |
CTD |
PMID:18355885 |
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NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
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G |
Ovol1 |
ovo like transcriptional repressor 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of OVOL1 mRNA; Ketoconazole results in increased expression of OVOL1 protein |
CTD |
PMID:26873447 |
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NCBI chr 1:202,855,261...202,868,858
Ensembl chr 1:202,855,265...202,866,831
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Pc |
pyruvate carboxylase |
affects expression |
EXP |
Ketoconazole affects the expression of PC mRNA |
CTD |
PMID:18355885 |
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NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
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G |
Pcsk9 |
proprotein convertase subtilisin/kexin type 9 |
increases expression |
EXP |
Ketoconazole results in increased expression of PCSK9 mRNA |
CTD |
PMID:28263823 |
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NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
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Pecr |
peroxisomal trans-2-enoyl-CoA reductase |
affects expression |
EXP |
Ketoconazole affects the expression of PECR mRNA |
CTD |
PMID:18355885 |
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NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
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G |
Plekha4 |
pleckstrin homology domain containing A4 |
increases expression |
EXP |
Ketoconazole results in increased expression of PLEKHA4 mRNA |
CTD |
PMID:28263823 |
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NCBI chr 1:96,005,824...96,028,826
Ensembl chr 1:96,006,000...96,028,826
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Pmvk |
phosphomevalonate kinase |
increases expression |
EXP |
Ketoconazole results in increased expression of PMVK mRNA |
CTD |
PMID:28263823 |
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NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364
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G |
Pomc |
proopiomelanocortin |
decreases expression |
ISO |
Ketoconazole results in decreased expression of POMC protein modified form |
CTD |
PMID:25808816 |
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NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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Por |
cytochrome p450 oxidoreductase |
affects expression increases expression multiple interactions |
EXP ISO |
Ketoconazole affects the expression of POR mRNA Ketoconazole results in increased expression of POR protein Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] |
CTD |
PMID:17966066 PMID:18355885 PMID:24120545 |
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NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Pou5f1 |
POU class 5 homeobox 1 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of POU5F1 mRNA |
CTD |
PMID:16574651 |
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NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [Clofibrate results in increased expression of PPARA mRNA] |
CTD |
PMID:14690017 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Ppp2cb |
protein phosphatase 2 catalytic subunit beta |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PPP2CB mRNA |
CTD |
PMID:25787151 |
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NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
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Prdx3 |
peroxiredoxin 3 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PRDX3 mRNA |
CTD |
PMID:25787151 |
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NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
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G |
Prkn |
parkin RBR E3 ubiquitin protein ligase |
multiple interactions increases response to substance increases expression |
EXP |
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN protein]; tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA]; tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN protein] PRKN protein results in increased susceptibility to Ketoconazole Ketoconazole results in increased expression of PRKN mRNA; Ketoconazole results in increased expression of PRKN protein |
CTD |
PMID:25787151 |
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NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
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Prl |
prolactin |
decreases expression |
EXP |
Ketoconazole results in decreased expression of PRL mRNA |
CTD |
PMID:25808816 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Ptger2 |
prostaglandin E receptor 2 |
multiple interactions increases response to substance |
ISO |
PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]] PTGER2 protein results in increased susceptibility to Ketoconazole |
CTD |
PMID:16784723 |
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NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
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G |
Ptger3 |
prostaglandin E receptor 3 |
multiple interactions increases response to substance |
ISO |
PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]] PTGER3 protein results in increased susceptibility to Ketoconazole |
CTD |
PMID:16784723 |
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NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO |
Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein] Ketoconazole results in increased expression of PTGS2 mRNA |
CTD |
PMID:12164941 PMID:32816093 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Pth |
parathyroid hormone |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [25-hydroxyvitamin D results in decreased expression of PTH mRNA] |
CTD |
PMID:18304585 |
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NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
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Rarb |
retinoic acid receptor, beta |
increases expression |
EXP |
Ketoconazole results in increased expression of RARB mRNA |
CTD |
PMID:28263823 |
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NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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G |
Rbl2 |
RB transcriptional corepressor like 2 |
affects expression |
EXP |
Ketoconazole affects the expression of RBL2 mRNA |
CTD |
PMID:18355885 |
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NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein] |
CTD |
PMID:31168027 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Ren |
renin |
decreases expression |
ISO |
Ketoconazole results in decreased expression of REN protein |
CTD |
PMID:2632720 |
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NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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G |
Rflna |
refilin A |
increases expression |
EXP |
Ketoconazole results in increased expression of RFLNA mRNA |
CTD |
PMID:28263823 |
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NCBI chr12:31,633,361...31,642,317
Ensembl chr12:31,633,361...31,642,317
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G |
Rnf41 |
ring finger protein 41 |
increases expression |
EXP |
Ketoconazole results in increased expression of RNF41 mRNA |
CTD |
PMID:25787151 |
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NCBI chr 7:838,160...876,869
Ensembl chr 7:838,203...865,511
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G |
RT1-S3 |
RT1 class Ib, locus S3 |
affects expression |
EXP |
Ketoconazole affects the expression of RT1-S3 mRNA |
CTD |
PMID:18355885 |
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NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
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G |
Runx2 |
RUNX family transcription factor 2 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of RUNX2 mRNA] |
CTD |
PMID:21542014 |
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NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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G |
Sc5d |
sterol-C5-desaturase |
increases expression |
EXP |
Ketoconazole results in increased expression of SC5D mRNA |
CTD |
PMID:28263823 |
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NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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G |
Scd |
stearoyl-CoA desaturase |
increases expression |
EXP |
Ketoconazole results in increased expression of SCD1 mRNA |
CTD |
PMID:28263823 |
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NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Sema3b |
semaphorin 3B |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of SEMA3B mRNA] |
CTD |
PMID:12040012 |
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NCBI chr 8:108,271,663...108,280,326
Ensembl chr 8:108,271,666...108,282,919
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G |
Serpina3n |
serine (or cysteine) peptidase inhibitor, clade A, member 3N |
increases expression |
ISO |
Ketoconazole results in increased expression of SERPINA3 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 6:123,323,632...123,331,166
Ensembl chr 6:123,323,629...123,332,433
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G |
Serpinb1a |
serpin family B member 1A |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in increased expression of SERPINB1 mRNA] |
CTD |
PMID:26485663 |
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NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102
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G |
Serpinb3 |
serpin family B member 3 |
multiple interactions |
ISO |
Ketoconazole promotes the reaction [Calcitriol results in decreased expression of SERPINB3 mRNA] |
CTD |
PMID:12040012 |
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NCBI chr13:23,274,120...23,280,082
Ensembl chr13:23,274,484...23,313,682
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G |
Serpinh1 |
serpin family H member 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Tunicamycin results in decreased glycosylation of SERPINH1 protein] |
CTD |
PMID:16330322 |
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NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801
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G |
Sh3gl3 |
SH3 domain containing GRB2 like 3, endophilin A3 |
affects expression |
EXP |
Ketoconazole affects the expression of SH3GL3 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 1:136,124,502...136,255,669
Ensembl chr 1:136,124,499...136,255,584
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G |
Slc10a1 |
solute carrier family 10 member 1 |
multiple interactions |
EXP |
[Chenodeoxycholic Acid co-treated with Ketoconazole] results in decreased expression of SLC10A1 mRNA |
CTD |
PMID:30985903 |
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NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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G |
Slc18a2 |
solute carrier family 18 member A2 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Maneb results in decreased expression of SLC18A2 protein]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of SLC18A2 protein] |
CTD |
PMID:22334051 |
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NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
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G |
Slc2a3 |
solute carrier family 2 member 3 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of SLC2A3 mRNA |
CTD |
PMID:15342952 PMID:17567588 |
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NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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G |
Slc47a1 |
solute carrier family 47 member 1 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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G |
Slc47a2 |
solute carrier family 47 member 2 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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G |
Slc6a6 |
solute carrier family 6 member 6 |
affects expression |
EXP |
Ketoconazole affects the expression of SLC6A6 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
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G |
Slc7a11 |
solute carrier family 7 member 11 |
increases expression |
ISO |
Ketoconazole results in increased expression of SLC7A11 mRNA |
CTD |
PMID:32816093 |
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NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
affects expression |
EXP |
Ketoconazole affects the expression of SLCO1A4 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G |
Slpi |
secretory leukocyte peptidase inhibitor |
decreases expression |
ISO |
Ketoconazole results in decreased expression of SLPI mRNA |
CTD |
PMID:32816093 |
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NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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G |
Sphk1 |
sphingosine kinase 1 |
increases expression |
EXP |
Ketoconazole results in increased expression of SPHK1 mRNA |
CTD |
PMID:25787151 |
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NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
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G |
Sqle |
squalene epoxidase |
increases expression |
EXP |
Ketoconazole results in increased expression of SQLE mRNA |
CTD |
PMID:28263823 |
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NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
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G |
Srebf2 |
sterol regulatory element binding transcription factor 2 |
increases expression |
EXP |
Ketoconazole results in increased expression of SREBF2 mRNA |
CTD |
PMID:28263823 |
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NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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G |
St13 |
ST13, Hsp70 interacting protein |
affects expression |
EXP |
Ketoconazole affects the expression of ST13 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945
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G |
Star |
steroidogenic acute regulatory protein |
increases expression |
ISO |
Ketoconazole results in increased expression of STAR mRNA |
CTD |
PMID:10960482 |
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NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Stard4 |
StAR-related lipid transfer domain containing 4 |
increases expression |
EXP |
Ketoconazole results in increased expression of STARD4 mRNA |
CTD |
PMID:28263823 |
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NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024
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G |
Stat1 |
signal transducer and activator of transcription 1 |
increases expression multiple interactions |
EXP ISO |
Ketoconazole results in increased expression of STAT1 mRNA Ketoconazole inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein] |
CTD |
PMID:24471457 PMID:25787151 |
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NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Stbd1 |
starch binding domain 1 |
affects expression |
EXP |
Ketoconazole affects the expression of STBD1 mRNA |
CTD |
PMID:18355885 |
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NCBI chr14:15,470,452...15,473,857
Ensembl chr14:15,469,582...15,477,443
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G |
Stmn1 |
stathmin 1 |
affects expression |
EXP |
Ketoconazole affects the expression of STMN1 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
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G |
Stra8 |
stimulated by retinoic acid 8 |
increases expression |
ISO |
Ketoconazole results in increased expression of STRA8 mRNA |
CTD |
PMID:16461896 |
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NCBI chr 4:63,601,443...63,624,777
Ensembl chr 4:63,601,604...63,624,771
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G |
Sycp3 |
synaptonemal complex protein 3 |
increases expression |
ISO |
Ketoconazole results in increased expression of SYCP3 mRNA |
CTD |
PMID:16574651 |
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NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511
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G |
Tagln |
transgelin |
decreases expression |
ISO |
Ketoconazole results in decreased expression of TAGLN mRNA |
CTD |
PMID:17175557 |
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NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
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G |
Tat |
tyrosine aminotransferase |
decreases expression |
ISO |
Ketoconazole results in decreased expression of TAT mRNA |
CTD |
PMID:16608920 PMID:25000292 |
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NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
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G |
Tex261 |
testis expressed 261 |
affects expression |
EXP |
Ketoconazole affects the expression of TEX261 mRNA |
CTD |
PMID:18355885 |
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NCBI chr 4:116,253,547...116,260,730
Ensembl chr 4:116,244,600...116,260,253
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G |
Th |
tyrosine hydroxylase |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Maneb results in decreased expression of TH protein]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of TH protein] |
CTD |
PMID:19594327 PMID:22334051 |
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NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G |
Timm10b |
translocase of inner mitochondrial membrane 10B |
affects expression |
EXP |
Ketoconazole affects the expression of TIMM10B mRNA |
CTD |
PMID:18355885 |
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NCBI chr 1:159,980,525...159,983,371
Ensembl chr 1:159,980,484...159,981,642
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of TIMP1 mRNA |
CTD |
PMID:18289764 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tmsb10 |
thymosin, beta 10 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of TMSB10 mRNA |
CTD |
PMID:18289764 |
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NCBI chr 4:105,009,959...105,011,095
Ensembl chr 4:105,009,212...105,011,028
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G |
Tnf |
tumor necrosis factor |
increases expression multiple interactions |
ISO EXP |
Ketoconazole results in increased expression of TNF mRNA Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] Ketoconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Ketoconazole inhibits the reaction [Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNF protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; Ketoconazole promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]] |
CTD |
PMID:11135059 PMID:12388057 PMID:15703382 PMID:16784723 PMID:21753779 PMID:22785256 PMID:25808816 PMID:31168027 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
increases expression |
ISO |
Ketoconazole results in increased expression of TNFRSF1A mRNA |
CTD |
PMID:25808816 |
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NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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G |
Tnfrsf1b |
TNF receptor superfamily member 1B |
increases expression |
ISO EXP |
Ketoconazole results in increased expression of TNFRSF1B mRNA |
CTD |
PMID:25808816 |
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NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNFSF10 protein]] |
CTD |
PMID:15703382 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G |
Tp63 |
tumor protein p63 |
decreases expression |
ISO |
Ketoconazole results in decreased expression of TRP63 mRNA |
CTD |
PMID:25808816 |
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NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
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G |
Tp73 |
tumor protein p73 |
decreases expression |
EXP |
Ketoconazole results in decreased expression of TP73 mRNA |
CTD |
PMID:25808816 |
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NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
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G |
Tslp |
thymic stromal lymphopoietin |
multiple interactions |
ISO |
4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] |
CTD |
PMID:23688403 |
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NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
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G |
Uba52 |
ubiquitin A-52 residue ribosomal protein fusion product 1 |
affects expression |
EXP |
Ketoconazole affects the expression of UBA52 mRNA |
CTD |
PMID:18355885 |
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NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
affects expression decreases expression decreases activity multiple interactions |
EXP ISO |
Ketoconazole affects the expression of UGT1A1 mRNA Ketoconazole results in decreased expression of UGT1A1 mRNA Ketoconazole results in decreased activity of UGT1A1 protein [Ketoconazole results in decreased activity of UGT1A1 protein] which results in decreased metabolism of irinotecan |
CTD |
PMID:16608920 PMID:18355885 PMID:22447115 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt2a1 |
UDP glucuronosyltransferase family 2 member A1 |
affects expression |
EXP |
Ketoconazole affects the expression of UGT2A1 mRNA |
CTD |
PMID:18355885 |
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NCBI chr14:20,521,018...20,545,060
Ensembl chr14:20,517,951...20,545,531
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G |
Ugt2b17 |
UDP glucuronosyltransferase family 2 member B17 |
affects expression |
EXP |
Ketoconazole affects the expression of UGT2B1 mRNA |
CTD |
PMID:18355885 |
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NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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G |
Vdr |
vitamin D receptor |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]; Ketoconazole inhibits the reaction [Vitamin D analog results in increased activity of VDR protein] |
CTD |
PMID:16280049 PMID:24792400 |
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NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]]; Ketoconazole inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA] |
CTD |
PMID:21566342 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Vim |
vimentin |
affects expression |
EXP |
Ketoconazole affects the expression of VIM mRNA |
CTD |
PMID:18289764 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Wipi1 |
WD repeat domain, phosphoinositide interacting 1 |
increases expression |
ISO |
Ketoconazole results in increased expression of WIPI1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
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