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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine
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Accession:CHEBI:48339 term browser browse the term
Definition:A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Synonyms:related_synonym: Formula=C26H28Cl2N4O4;   InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3;   InChIKey=XMAYWYJOQHXEEK-UHFFFAOYSA-N;   SMILES=CC(=O)N1CCN(CC1)c1ccc(OCC2COC(Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1
 xref: Beilstein:634785;   DrugBank:DB01026;   LINCS:LSM-5148



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ketoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression EXP Ketoconazole results in decreased expression of A2M mRNA CTD PMID:18289764 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Aadat aminoadipate aminotransferase affects expression EXP Ketoconazole affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
JBrowse link
G Aamp angio-associated, migratory cell protein increases expression ISO Ketoconazole results in increased expression of AAMP mRNA CTD PMID:36621641 NCBI chr 9:75,863,382...75,869,188
Ensembl chr 9:75,863,389...75,868,547
JBrowse link
G Aatf apoptosis antagonizing transcription factor decreases expression EXP Ketoconazole results in decreased expression of AATF mRNA CTD PMID:25787151 NCBI chr10:69,299,029...69,392,207
Ensembl chr10:69,299,037...69,392,201
JBrowse link
G Abat 4-aminobutyrate aminotransferase increases expression EXP Ketoconazole results in increased expression of ABAT mRNA CTD PMID:37077353 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
decreases expression
EXP Ketoconazole inhibits the reaction [Clofibrate results in increased expression of ABCA1 mRNA]
Ketoconazole results in decreased expression of ABCA1 mRNA
CTD PMID:14690017 PMID:37077353 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abca3 ATP binding cassette subfamily A member 3 decreases expression EXP Ketoconazole results in decreased expression of ABCA3 mRNA CTD PMID:37077353 NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO [Ketoconazole results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Ketoconazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] CTD PMID:20147439 PMID:20829430 PMID:23956101 PMID:24014644 PMID:28437613 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
decreases activity
decreases expression
affects expression
ISO
EXP
ABCB1 protein results in increased transport of Ketoconazole
[Ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of Digoxin; Ketoconazole binds to and results in decreased activity of ABCB1 protein; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Glucosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Lactosylceramides]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Ketoconazole inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; Ketoconazole inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Ethanol results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Hydrogen Peroxide affects the expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCB1 mRNA]
Ketoconazole results in decreased expression of ABCB1 mRNA
Ketoconazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 protein]
Ketoconazole affects the expression of ABCB1 mRNA
Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCB1A mRNA]
Ketoconazole results in decreased expression of ABCB1A mRNA
CTD PMID:10350002 PMID:12235267 PMID:14662772 PMID:15969931 PMID:16819505 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity
multiple interactions
ISO
EXP
Ketoconazole results in decreased activity of ABCB4 protein
[Chenodeoxycholic Acid co-treated with Ketoconazole] results in increased expression of ABCB4 mRNA
CTD PMID:28437613 PMID:30985903 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO Ketoconazole inhibits the reaction [titanium dioxide results in increased expression of ABCC1 mRNA] CTD PMID:33766574 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases activity
multiple interactions
ISO
EXP
Ketoconazole results in decreased activity of ABCC2 protein
Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCC2 mRNA]
CTD PMID:19070657 PMID:19766108 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 increases expression EXP Ketoconazole results in increased expression of ABCD2 mRNA CTD PMID:36653537 NCBI chr 7:122,263,034...122,311,642
Ensembl chr 7:122,263,032...122,311,642
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression
EXP Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCG2 mRNA]
Ketoconazole results in increased expression of ABCG2 mRNA
CTD PMID:32185415 PMID:37077353 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Abracl ABRA C-terminal like decreases expression ISO Ketoconazole results in decreased expression of ABRACL mRNA CTD PMID:36621641 NCBI chr 1:12,654,951...12,665,143
Ensembl chr 1:12,654,838...12,665,207
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases expression EXP Ketoconazole results in increased expression of ACAA1 mRNA CTD PMID:37077353 NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 increases expression EXP Ketoconazole results in increased expression of ACAA2 mRNA CTD PMID:37077353 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain increases expression EXP Ketoconazole results in increased expression of ACADL mRNA CTD PMID:37077353 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain increases expression EXP Ketoconazole results in increased expression of ACADM mRNA CTD PMID:37077353 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acads acyl-CoA dehydrogenase short chain increases expression EXP Ketoconazole results in increased expression of ACADS mRNA CTD PMID:37077353 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
JBrowse link
G Ace2 angiotensin converting enzyme 2 increases expression ISO Ketoconazole results in increased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acot8 acyl-CoA thioesterase 8 increases expression EXP Ketoconazole results in increased expression of ACOT8 mRNA CTD PMID:37077353 NCBI chr 3:153,531,192...153,542,851
Ensembl chr 3:153,531,193...153,542,851
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression EXP Ketoconazole results in decreased expression of ACSL4 mRNA CTD PMID:37077353 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 increases expression EXP Ketoconazole results in increased expression of ACSL5 mRNA CTD PMID:37077353 NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 decreases expression EXP Ketoconazole results in decreased expression of ACSM1 mRNA CTD PMID:28263823 NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 affects expression EXP Ketoconazole affects the expression of ADAM9 mRNA CTD PMID:25787151 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917
JBrowse link
G Adcy6 adenylate cyclase 6 decreases expression EXP Ketoconazole results in decreased expression of ADCY6 mRNA CTD PMID:37077353 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide decreases expression EXP Ketoconazole results in decreased expression of ADH1 mRNA CTD PMID:36653537 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Adi1 acireductone dioxygenase 1 decreases expression ISO Ketoconazole results in decreased expression of ADI1 mRNA CTD PMID:36621641 NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression EXP Ketoconazole results in increased expression of ADIPOQ mRNA CTD PMID:36653537 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP Ketoconazole results in increased expression of ADIPOR2 mRNA CTD PMID:37077353 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
JBrowse link
G Adora1 adenosine A1 receptor increases expression EXP Ketoconazole results in increased expression of ADORA1 mRNA CTD PMID:37077353 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression EXP Ketoconazole results in increased expression of ADRB2 mRNA CTD PMID:37077353 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Aebp2 AE binding protein 2 decreases expression ISO Ketoconazole results in decreased expression of AEBP2 mRNA CTD PMID:36621641 NCBI chr 4:173,527,881...173,566,033
Ensembl chr 4:173,528,344...173,593,100
JBrowse link
G Agps alkylglycerone phosphate synthase increases expression ISO Ketoconazole results in increased expression of AGPS mRNA CTD PMID:36621641 NCBI chr 3:60,747,323...60,845,831
Ensembl chr 3:60,747,323...60,845,830
JBrowse link
G Agrp agouti related neuropeptide decreases expression EXP Ketoconazole results in decreased expression of AGRP mRNA CTD PMID:37077353 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
JBrowse link
G Agt angiotensinogen increases expression EXP Ketoconazole results in increased expression of AGT mRNA CTD PMID:37077353 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
increases expression
ISO
EXP
AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 protein]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]
Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of AHR protein]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AHR protein]
[Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; Ketoconazole results in increased activity of and results in increased localization of AHR protein
Ketoconazole results in increased expression of AHR mRNA
CTD PMID:17505019 PMID:17923278 PMID:21753779 PMID:25000292 PMID:31168027 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions
increases expression
EXP [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of AHRR mRNA
Ketoconazole results in increased expression of AHRR mRNA
CTD PMID:31168027 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673
JBrowse link
G Ahsg alpha-2-HS-glycoprotein increases expression EXP Ketoconazole results in increased expression of AHSG mRNA CTD PMID:36653537 NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999
JBrowse link
G Akap12 A-kinase anchoring protein 12 decreases expression ISO Ketoconazole results in decreased expression of AKAP12 mRNA CTD PMID:36621641 NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 increases expression EXP Ketoconazole results in increased expression of AKR1B7 mRNA CTD PMID:36653537 NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502
JBrowse link
G Akr1c15 aldo-keto reductase family 1, member C15 increases expression EXP Ketoconazole results in increased expression of AKR1C15 mRNA CTD PMID:36653537 NCBI chr17:66,181,493...66,208,090
Ensembl chr17:66,181,493...66,208,061
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression EXP Ketoconazole results in increased expression of ALAS1 mRNA CTD PMID:36653537 NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Alb albumin affects expression EXP Ketoconazole affects the expression of ALB mRNA CTD PMID:36653537 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects expression EXP Ketoconazole affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 affects expression EXP Ketoconazole affects the expression of ALDH1A4 mRNA CTD PMID:18355885 NCBI chr 1:218,201,443...218,241,410
Ensembl chr 1:218,201,472...218,248,906
JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 decreases expression ISO Ketoconazole results in decreased expression of ALDH7A1 mRNA CTD PMID:36621641 NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
JBrowse link
G Alkbh7 alkB homolog 7 decreases expression EXP Ketoconazole results in decreased expression of ALKBH7 mRNA CTD PMID:36653537 NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases expression
ISO Ketoconazole inhibits the reaction [Calcifediol results in increased expression of ALPL mRNA]
Ketoconazole results in increased expression of ALPL protein
CTD PMID:21542014 PMID:31099283 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Amdhd1 amidohydrolase domain containing 1 decreases expression ISO Ketoconazole results in decreased expression of AMDHD1 mRNA CTD PMID:31099283 NCBI chr 7:28,043,923...28,059,156
Ensembl chr 7:28,043,716...28,059,156
JBrowse link
G Amh anti-Mullerian hormone increases expression ISO Ketoconazole results in increased expression of AMH protein CTD PMID:16684832 NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282
JBrowse link
G Ang angiogenin increases expression ISO Ketoconazole results in increased expression of ANG mRNA CTD PMID:36621641 NCBI chr15:24,312,711...24,323,361 JBrowse link
G Anxa1 annexin A1 decreases expression EXP Ketoconazole results in decreased expression of ANXA1 mRNA CTD PMID:25787151 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Aox1 aldehyde oxidase 1 decreases expression EXP Ketoconazole results in decreased expression of AOX1 mRNA CTD PMID:36653537 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Ketoconazole results in decreased expression of AP1S1 mRNA CTD PMID:17175557 NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
JBrowse link
G Ap3m1 adaptor related protein complex 3 subunit mu 1 decreases expression ISO Ketoconazole results in decreased expression of AP3M1 mRNA CTD PMID:36621641 NCBI chr15:3,246,616...3,264,846
Ensembl chr15:3,246,926...3,264,844
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression EXP Ketoconazole results in decreased expression of APAF1 mRNA CTD PMID:37077353 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Apoa1 apolipoprotein A1 increases expression EXP Ketoconazole results in increased expression of APOA1 mRNA CTD PMID:36653537 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP Ketoconazole affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Apoe apolipoprotein E increases expression EXP Ketoconazole results in increased expression of APOE mRNA CTD PMID:37077353 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Ar androgen receptor multiple interactions
decreases activity
increases activity
decreases expression
ISO
EXP
[Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of AR protein; Ketoconazole inhibits the reaction [Metribolone results in increased activity of AR protein]; Ketoconazole inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]
Ketoconazole results in decreased activity of AR protein
Ketoconazole results in increased activity of AR protein
Ketoconazole results in decreased expression of AR protein
Ketoconazole inhibits the reaction [Phenytoin results in increased expression of AR protein]
CTD PMID:11118046 PMID:18324785 PMID:19226368 PMID:19587329 PMID:24323034 More... NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arg1 arginase 1 increases expression EXP Ketoconazole results in increased expression of ARG1 mRNA CTD PMID:37077353 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Asb17 ankyrin repeat and SOCS box-containing 17 increases expression ISO Ketoconazole results in increased expression of ASB17 mRNA CTD PMID:31099283 NCBI chr 2:242,775,887...242,786,950
Ensembl chr 2:242,775,994...242,786,903
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Ketoconazole results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Ass1 argininosuccinate synthase 1 increases expression EXP Ketoconazole results in increased expression of ASS1 mRNA CTD PMID:36653537 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Atad2 ATPase family, AAA domain containing 2 increases expression ISO Ketoconazole results in increased expression of ATAD2 mRNA CTD PMID:36621641 NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738
JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein] CTD PMID:12164941 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
JBrowse link
G Atp5mc2 ATP synthase membrane subunit c locus 2 increases expression ISO Ketoconazole results in increased expression of ATP5MC2 mRNA CTD PMID:36621641 NCBI chr 7:133,791,341...133,799,713
Ensembl chr 7:133,791,342...133,799,733
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP increases expression EXP Ketoconazole results in increased expression of ATP5PO mRNA CTD PMID:37077353 NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592
JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D increases expression EXP Ketoconazole results in increased expression of ATP6V1D mRNA CTD PMID:37077353 NCBI chr 6:97,656,725...97,672,295
Ensembl chr 6:97,656,576...97,672,303
JBrowse link
G Avp arginine vasopressin increases expression EXP Ketoconazole results in increased expression of AVP mRNA CTD PMID:37077353 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bace1 beta-secretase 1 decreases expression EXP Ketoconazole results in decreased expression of BACE1 mRNA CTD PMID:37077353 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression EXP Ketoconazole results in increased expression of BAD mRNA CTD PMID:25787151 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; Ketoconazole inhibits the reaction [Calcifediol results in decreased expression of BAX mRNA] CTD PMID:21542014 PMID:31629065 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; Ketoconazole inhibits the reaction [Calcifediol results in increased expression of BCL2 mRNA] CTD PMID:21542014 PMID:31629065 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO Ketoconazole results in increased expression of BCL2L11 mRNA CTD PMID:25808816 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Becn1 beclin 1 increases expression EXP Ketoconazole results in increased expression of BECN1 mRNA CTD PMID:37077353 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase affects expression EXP Ketoconazole affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G Bicc1 BicC family RNA binding protein 1 decreases expression ISO Ketoconazole results in decreased expression of BICC1 mRNA CTD PMID:31099283 NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO Ketoconazole results in increased expression of BID mRNA CTD PMID:25808816 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Bin1 bridging integrator 1 increases expression EXP Ketoconazole results in increased expression of BIN1 mRNA CTD PMID:37077353 NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression EXP Ketoconazole results in increased expression of BIRC5 mRNA CTD PMID:37077353 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO Ketoconazole inhibits the reaction [menatetrenone promotes the reaction [Phosphates results in increased expression of BMP2 mRNA]]; Ketoconazole inhibits the reaction [Phosphates promotes the reaction [menatetrenone results in increased expression of BMP2 mRNA]] CTD PMID:31843813 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression EXP Ketoconazole results in decreased expression of BMP4 mRNA CTD PMID:36653537 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO Ketoconazole results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Bnc1 basonuclin zinc finger protein 1 decreases expression EXP Ketoconazole results in decreased expression of BNC1 mRNA CTD PMID:36653537 NCBI chr 1:135,917,676...135,943,333
Ensembl chr 1:135,917,687...135,943,333
JBrowse link
G Bnip1 BCL2 interacting protein 1 increases expression ISO Ketoconazole results in increased expression of BNIP1 mRNA CTD PMID:25808816 NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157
JBrowse link
G Bnip2 BCL2 interacting protein 2 increases expression EXP Ketoconazole results in increased expression of BNIP2 mRNA CTD PMID:25808816 NCBI chr 8:70,640,436...70,661,782
Ensembl chr 8:70,640,445...70,675,590
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Ketoconazole results in increased expression of BNIP3 mRNA CTD PMID:25808816 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Bnip3l BCL2 interacting protein 3 like decreases expression ISO Ketoconazole results in decreased expression of BNIP3L mRNA CTD PMID:36621641 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G C10h5orf15 similar to human chromosome 5 open reading frame 15 increases expression ISO Ketoconazole results in increased expression of C5ORF15 mRNA CTD PMID:36621641 NCBI chr10:36,563,989...36,576,593
Ensembl chr10:36,563,958...36,576,590
JBrowse link
G C1galt1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 decreases expression ISO Ketoconazole results in decreased expression of C1GALT1 mRNA CTD PMID:36621641 NCBI chr 4:35,930,981...35,966,100
Ensembl chr 4:35,928,104...35,961,831
JBrowse link
G C1galt1c1 C1GALT1-specific chaperone 1 decreases expression ISO Ketoconazole results in decreased expression of C1GALT1C1 mRNA CTD PMID:36621641 NCBI chr  X:117,378,123...117,382,620
Ensembl chr  X:117,375,525...117,382,787
JBrowse link
G C3 complement C3 increases expression EXP Ketoconazole results in increased expression of C3 mRNA CTD PMID:37077353 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C5h1orf174 similar to human chromosome 1 open reading frame 174 increases expression ISO Ketoconazole results in increased expression of C1ORF174 mRNA CTD PMID:36621641 NCBI chr 5:164,515,578...164,520,022
Ensembl chr 5:164,515,559...164,520,021
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H decreases expression EXP Ketoconazole results in decreased expression of CACNA1H mRNA CTD PMID:37077353 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I decreases expression EXP Ketoconazole results in decreased expression of CACNA1I mRNA CTD PMID:37077353 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
JBrowse link
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 increases expression EXP Ketoconazole results in increased expression of CACNA2D3 mRNA CTD PMID:37077353 NCBI chr16:4,098,439...4,912,498
Ensembl chr16:4,098,445...4,912,351
JBrowse link
G Cacna2d4 calcium voltage-gated channel auxiliary subunit alpha2delta 4 increases expression EXP Ketoconazole results in increased expression of CACNA2D4 mRNA CTD PMID:37077353 NCBI chr 4:152,408,588...152,521,478
Ensembl chr 4:152,408,657...152,521,268
JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 decreases expression EXP Ketoconazole results in decreased expression of CACNB1 mRNA CTD PMID:37077353 NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694
JBrowse link
G Cacng3 calcium voltage-gated channel auxiliary subunit gamma 3 increases expression EXP Ketoconazole results in increased expression of CACNG3 mRNA CTD PMID:37077353 NCBI chr 1:177,201,361...177,297,019
Ensembl chr 1:177,201,288...177,297,024
JBrowse link
G Cacng4 calcium voltage-gated channel auxiliary subunit gamma 4 decreases expression EXP Ketoconazole results in decreased expression of CACNG4 mRNA CTD PMID:37077353 NCBI chr10:92,683,778...92,745,842
Ensembl chr10:92,683,761...92,746,126
JBrowse link
G Calb1 calbindin 1 decreases expression ISO Ketoconazole results in decreased expression of CALB1 mRNA CTD PMID:31099283 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431
JBrowse link
G Calb2 calbindin 2 decreases expression EXP Ketoconazole results in decreased expression of CALB2 mRNA CTD PMID:36653537 NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438
JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 increases expression EXP Ketoconazole results in increased expression of CAP1 mRNA CTD PMID:36653537 NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769
JBrowse link
G Car2 carbonic anhydrase 2 increases expression EXP Ketoconazole results in increased expression of CA2 mRNA; Ketoconazole results in increased expression of CAR2 mRNA CTD PMID:37077353 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Carmil1 capping protein regulator and myosin 1 linker 1 decreases expression ISO Ketoconazole results in decreased expression of CARMIL1 mRNA CTD PMID:36621641 NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326
JBrowse link
G Casp12 caspase 12 increases expression ISO Ketoconazole results in increased expression of CASP12 mRNA CTD PMID:25808816 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Ketoconazole results in increased activity of CASP3 protein
Ketoconazole inhibits the reaction [Galactosamine results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Ketoconazole results in increased activity of CASP3 protein]
CTD PMID:17936189 PMID:19631732 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 decreases expression
increases expression
EXP Ketoconazole results in decreased expression of CASP6 mRNA
Ketoconazole results in increased expression of CASP6 mRNA
CTD PMID:25787151 PMID:25808816 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp7 caspase 7 increases expression EXP Ketoconazole results in increased expression of CASP7 mRNA CTD PMID:25808816 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8ap2 caspase 8 associated protein 2 affects expression ISO Ketoconazole affects the expression of CASP8AP2 mRNA CTD PMID:36621641 NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275
JBrowse link
G Casp9 caspase 9 increases expression ISO Ketoconazole results in increased expression of CASP9 mRNA CTD PMID:25808816 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases expression EXP Ketoconazole results in decreased expression of CAT mRNA CTD PMID:25787151 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav1 caveolin 1 increases expression ISO Ketoconazole results in increased expression of CAV1 mRNA CTD PMID:36621641 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cbx7 chromobox 7 increases expression EXP Ketoconazole results in increased expression of CBX7 mRNA CTD PMID:37077353 NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973
JBrowse link
G Ccdc8 coiled-coil domain containing 8 increases expression EXP Ketoconazole results in increased expression of CCDC8 mRNA CTD PMID:36653537 NCBI chr 1:77,679,521...77,682,849
Ensembl chr 1:77,679,218...77,683,090
JBrowse link
G Cck cholecystokinin increases expression EXP Ketoconazole results in increased expression of CCK mRNA CTD PMID:37077353 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO
EXP
Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]
Ketoconazole results in increased expression of CCL2 mRNA
CTD PMID:16784723 PMID:37077353 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl27 C-C motif chemokine ligand 27 multiple interactions ISO Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]] CTD PMID:16784723 NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression
ISO
EXP
Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
Ketoconazole results in increased expression of CCL5 mRNA
CTD PMID:16784723 PMID:23688403 PMID:37077353 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression
affects expression
ISO
EXP
Ketoconazole results in increased expression of CCN1 mRNA
Ketoconazole affects the expression of CCN1 mRNA
CTD PMID:36621641 PMID:36653537 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccng1 cyclin G1 increases expression EXP Ketoconazole results in increased expression of CCNG1 mRNA CTD PMID:18289764 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Cd200 Cd200 molecule increases expression ISO Ketoconazole results in increased expression of CD200 mRNA CTD PMID:36621641 NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648
JBrowse link
G Cd247 Cd247 molecule multiple interactions ISO Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr13:78,043,302...78,118,437
Ensembl chr13:78,043,307...78,122,263
JBrowse link
G Cd274 CD274 molecule decreases expression EXP Ketoconazole results in decreased expression of CD274 mRNA CTD PMID:37077353 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cd28 Cd28 molecule multiple interactions ISO Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cd3d CD3 delta subunit of T-cell receptor complex multiple interactions ISO Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809
JBrowse link
G Cd3e CD3 epsilon subunit of T-cell receptor complex multiple interactions ISO Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 8:45,303,848...45,315,005
Ensembl chr 8:45,303,852...45,315,022
JBrowse link
G Cd3g CD3 gamma subunit of T-cell receptor complex multiple interactions ISO Ketoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 8:45,280,797...45,287,271
Ensembl chr 8:45,281,204...45,287,147
JBrowse link
G Cd47 Cd47 molecule increases expression ISO Ketoconazole results in increased expression of CD47 mRNA CTD PMID:36621641 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
JBrowse link
G Cdc42ep2 CDC42 effector protein 2 decreases expression EXP Ketoconazole results in decreased expression of CDC42EP2 mRNA CTD PMID:36653537 NCBI chr 1:203,202,000...203,210,891
Ensembl chr 1:203,201,873...203,210,897
JBrowse link
G Cdc42ep3 CDC42 effector protein 3 increases expression EXP Ketoconazole results in increased expression of CDC42EP3 mRNA CTD PMID:28263823 NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression EXP Ketoconazole results in decreased expression of CDK2 mRNA CTD PMID:37077353 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression EXP Ketoconazole results in decreased expression of CDK6 mRNA CTD PMID:37077353 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO
EXP
Ketoconazole results in increased expression of CDKN1A mRNA CTD PMID:16483768 PMID:25808816 PMID:37077353 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP Ketoconazole results in increased expression of CDKN1B mRNA CTD PMID:25808816 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression EXP Ketoconazole affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression EXP Ketoconazole results in increased expression of CEBPA mRNA CTD PMID:37077353 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cenpu centromere protein U decreases expression ISO Ketoconazole results in decreased expression of CENPU mRNA CTD PMID:36621641 NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823
JBrowse link
G Cep15 centrosomal protein 15 increases expression ISO Ketoconazole results in increased expression of CEP15 mRNA CTD PMID:36621641 NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838
JBrowse link
G Cep19 centrosomal protein 19 increases expression ISO Ketoconazole results in increased expression of CEP19 mRNA CTD PMID:36621641 NCBI chr11:68,677,869...68,687,117
Ensembl chr11:68,677,871...68,687,022
JBrowse link
G Ces2h carboxylesterase 2H affects expression EXP Ketoconazole affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cfb complement factor B increases expression EXP Ketoconazole results in increased expression of CFB mRNA CTD PMID:36653537 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide decreases expression ISO Ketoconazole results in decreased expression of CGA mRNA CTD PMID:25808816 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
JBrowse link
G Chrac1 chromatin accessibility complex subunit 1 increases expression ISO Ketoconazole results in increased expression of CHRAC1 mRNA CTD PMID:36621641 NCBI chr 7:105,013,047...105,016,435
Ensembl chr 7:105,013,015...105,017,136
JBrowse link
G Cibar1 CBY1 interacting BAR domain containing 1 decreases expression ISO Ketoconazole results in decreased expression of CIBAR1 mRNA CTD PMID:36621641 NCBI chr 5:25,613,993...25,632,440
Ensembl chr 5:25,614,033...25,632,489
JBrowse link
G Cidea cell death-inducing DFFA-like effector a increases expression EXP Ketoconazole results in increased expression of CIDEA mRNA CTD PMID:36653537 PMID:37077353 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
JBrowse link
G Ckap2l cytoskeleton associated protein 2-like decreases expression ISO Ketoconazole results in decreased expression of CKAP2L mRNA CTD PMID:36621641 NCBI chr 3:116,497,186...116,524,302
Ensembl chr 3:116,498,022...116,524,366
JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 increases expression ISO Ketoconazole results in increased expression of CLCF1 mRNA CTD PMID:31099283 NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605
JBrowse link
G Clec4e C-type lectin domain family 4, member E increases expression ISO Ketoconazole results in increased expression of CLEC4E mRNA CTD PMID:31099283 NCBI chr 4:156,606,927...156,612,911
Ensembl chr 4:156,607,614...156,612,767
JBrowse link
G Clmn calmin multiple interactions ISO Ketoconazole promotes the reaction [Calcitriol results in increased expression of CLMN mRNA] CTD PMID:26485663 NCBI chr 6:123,707,710...123,807,283
Ensembl chr 6:123,713,507...123,807,272
JBrowse link
G Cln5 CLN5, intracellular trafficking protein affects expression ISO Ketoconazole affects the expression of CLN5 mRNA CTD PMID:36621641 NCBI chr15:79,893,573...79,903,438
Ensembl chr15:79,893,548...79,903,438
JBrowse link
G Clu clusterin affects expression
decreases expression
EXP Ketoconazole affects the expression of CLU mRNA
Ketoconazole results in decreased expression of CLU mRNA
CTD PMID:17558187 PMID:18289764 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 affects expression EXP Ketoconazole affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 8:114,422,934...114,441,034
Ensembl chr 8:114,422,921...114,441,033
JBrowse link
G Cmtm7 CKLF-like MARVEL transmembrane domain containing 7 increases expression ISO Ketoconazole results in increased expression of CMTM7 mRNA CTD PMID:36621641 NCBI chr 8:114,448,037...114,474,958
Ensembl chr 8:114,448,042...114,474,621
JBrowse link
G Cnr2 cannabinoid receptor 2 decreases expression EXP Ketoconazole results in decreased expression of CNR2 mRNA CTD PMID:36653537 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Ketoconazole results in decreased expression of COL1A1 mRNA CTD PMID:37077353 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Commd2 COMM domain containing 2 decreases expression ISO Ketoconazole results in decreased expression of COMMD2 mRNA CTD PMID:36621641 NCBI chr 2:141,848,661...141,852,907
Ensembl chr 2:141,848,680...141,852,888
JBrowse link
G Cop1 COP1, E3 ubiquitin ligase decreases expression ISO Ketoconazole results in decreased expression of COP1 mRNA CTD PMID:36621641 NCBI chr13:71,467,164...71,561,826
Ensembl chr13:71,429,961...71,538,890
JBrowse link
G Copz1 COPI coat complex subunit zeta 1 decreases expression ISO Ketoconazole results in decreased expression of COPZ1 mRNA CTD PMID:36621641 NCBI chr 7:134,409,523...134,435,661
Ensembl chr 7:134,409,799...134,435,662
JBrowse link
G Cox18 cytochrome c oxidase assembly factor COX18 affects expression ISO Ketoconazole affects the expression of COX18 mRNA CTD PMID:36621641 NCBI chr14:17,864,581...17,877,483
Ensembl chr14:17,865,857...17,877,480
JBrowse link
G Cpn2 carboxypeptidase N subunit 2 decreases expression ISO Ketoconazole results in decreased expression of CPN2 mRNA CTD PMID:31099283 NCBI chr11:70,486,054...70,495,937
Ensembl chr11:70,486,057...70,496,472
JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 affects expression EXP Ketoconazole affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr10:3,701,522...3,821,050
Ensembl chr10:3,701,459...3,821,054
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression EXP Ketoconazole results in decreased expression of CPT1B mRNA CTD PMID:37077353 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression EXP Ketoconazole results in increased expression of CPT2 mRNA CTD PMID:37077353 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
JBrowse link
G Cr2 complement C3d receptor 2 increases expression EXP Ketoconazole results in increased expression of CR2 mRNA CTD PMID:37077353 NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases expression
ISO
EXP
Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]
Ketoconazole inhibits the reaction [Arachidonic Acid results in increased phosphorylation of CREB1 protein]; Ketoconazole inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]
Ketoconazole results in decreased expression of CREB1 mRNA
CTD PMID:12164941 PMID:17680988 PMID:37077353 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crem cAMP responsive element modulator affects expression
decreases expression
EXP Ketoconazole affects the expression of CREM mRNA
Ketoconazole results in decreased expression of CREM mRNA
CTD PMID:18355885 PMID:36653537 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 decreases expression EXP Ketoconazole results in decreased expression of CRHR2 mRNA CTD PMID:37077353 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
JBrowse link
G Crls1 cardiolipin synthase 1 increases expression EXP Ketoconazole results in increased expression of CRLS1 mRNA CTD PMID:36653537 NCBI chr 3:120,119,822...120,138,674
Ensembl chr 3:120,119,852...120,138,655
JBrowse link
G Crym crystallin, mu decreases expression EXP Ketoconazole results in decreased expression of CRYM mRNA CTD PMID:36653537 NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression EXP Ketoconazole results in decreased expression of CTNNB1 mRNA CTD PMID:37077353 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsl cathepsin L decreases expression ISO Ketoconazole results in decreased expression of CTSL mRNA CTD PMID:36621641 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Ctss cathepsin S affects expression EXP Ketoconazole affects the expression of CTSS mRNA CTD PMID:18289764 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Ketoconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; Ketoconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 protein] CTD PMID:24471457 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 increases expression EXP Ketoconazole results in increased expression of CXCL14 mRNA CTD PMID:37077353 NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839
JBrowse link
G Cyba cytochrome b-245 alpha chain increases expression EXP Ketoconazole results in increased expression of CYBA mRNA CTD PMID:37077353 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cycs cytochrome c, somatic decreases expression
increases expression
EXP Ketoconazole results in decreased expression of CYCS mRNA
Ketoconazole results in increased expression of CYCS mRNA
CTD PMID:25787151 PMID:37077353 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyct cytochrome c, testis increases expression EXP Ketoconazole results in increased expression of CYCT mRNA CTD PMID:25787151 NCBI chr 3:61,290,090...61,297,158
Ensembl chr 3:60,913,562...61,297,158
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression EXP Ketoconazole results in increased expression of CYP11A1 mRNA CTD PMID:26610754 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions
decreases activity
ISO Ketoconazole binds to and results in decreased activity of CYP11B1 protein
Ketoconazole results in decreased activity of CYP11B1 protein
CTD PMID:15743198 PMID:31982514 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases activity
increases expression
multiple interactions
ISO Ketoconazole results in decreased activity of CYP11B2 protein
Ketoconazole results in increased expression of CYP11B2 mRNA
Ketoconazole binds to and results in decreased activity of CYP11B2 protein; Ketoconazole promotes the reaction [Colforsin results in increased expression of CYP11B2 mRNA]
CTD PMID:15743198 PMID:16935330 PMID:31982514 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity
multiple interactions
decreases expression
ISO
EXP
Ketoconazole results in decreased activity of CYP17A1 protein
Ketoconazole inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]
Ketoconazole results in decreased expression of CYP17A1 mRNA
CTD PMID:11118046 PMID:15743198 PMID:15771425 PMID:15934942 PMID:16935330 More... NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity
decreases activity
multiple interactions
decreases expression
ISO
EXP
Ketoconazole results in increased activity of CYP19A1 protein
Ketoconazole results in decreased activity of CYP19A1 protein
[Ketoconazole results in increased activity of CYP19A1 protein] which results in increased chemical synthesis of Estrone; [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased metabolism of Androstenedione
Ketoconazole results in decreased expression of CYP19A1 mRNA
CTD PMID:20087668 PMID:27159630 PMID:31330226 PMID:36374910 PMID:36653537 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
multiple interactions
decreases activity
increases expression
ISO
EXP
Ketoconazole results in increased activity of CYP1A1 protein
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of CYP1A1 mRNA; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Ketoconazole results in decreased activity of CYP1A1 protein
[Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Ketoconazole results in increased activity of and results in increased localization of AHR protein] which results in increased expression of CYP1A1 protein; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of CYP1A1 mRNA]; Ketoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 protein
Ketoconazole results in increased expression of CYP1A1 mRNA; Ketoconazole results in increased expression of CYP1A1 protein
Ketoconazole binds to and results in decreased activity of and results in increased expression of CYP1A1 protein; Ketoconazole results in increased expression of and results in increased activity of CYP1A1 protein
CTD PMID:14709627 PMID:17283379 PMID:18420780 PMID:18493746 PMID:19070657 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases expression
ISO
EXP
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines]
Ketoconazole inhibits the reaction [CYP1A2 protein results in increased oxidation of Uroporphyrinogens]
Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin]
Ketoconazole results in decreased activity of CYP1A2 protein
Ketoconazole results in increased expression of CYP1A2 mRNA; Ketoconazole results in increased expression of CYP1A2 protein
CTD PMID:1567206 PMID:9305587 PMID:12814958 PMID:15618748 PMID:15879494 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Ketoconazole results in decreased activity of CYP1B1 protein CTD PMID:14709627 PMID:18420780 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions
decreases activity
EXP
ISO
[Ketoconazole co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA; Ketoconazole inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein]
Ketoconazole results in decreased activity of CYP24A1 protein
[Ketoconazole results in decreased metabolism of alfacalcidol] which results in decreased expression of CYP24A1 mRNA; [Ketoconazole results in decreased metabolism of Calcitriol] which results in increased expression of CYP24A1 mRNA; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]
CTD PMID:16483768 PMID:16824767 PMID:18840526 PMID:20206692 PMID:26485663 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases response to substance
multiple interactions
decreases activity
increases expression
ISO
EXP
Ketoconazole results in decreased susceptibility to CYP26A1 protein
[[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-hydroxyretinoic acid; [[Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-hydroxyretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased chemical synthesis of 4-oxoretinoic acid; [Ketoconazole results in decreased activity of CYP26A1 protein] which results in decreased metabolism of Tretinoin; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-hydroxyretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased chemical synthesis of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of 4-oxoretinoic acid]; Ketoconazole inhibits the reaction [CYP26A1 mRNA results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNF protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNFSF10 protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of and results in decreased susceptibility to Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 protein results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26A1 results in increased metabolism of Tretinoin]
Ketoconazole results in decreased activity of CYP26A1; Ketoconazole results in decreased activity of CYP26A1 protein
Ketoconazole results in increased expression of CYP26A1 mRNA
CTD PMID:12091498 PMID:14532297 PMID:15703382 PMID:18059332 PMID:21906690 More... NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 multiple interactions
decreases activity
ISO Ketoconazole inhibits the reaction [CYP26B1 protein results in increased metabolism of Tretinoin]; Ketoconazole inhibits the reaction [CYP26B1 results in increased metabolism of Tretinoin]
Ketoconazole results in decreased activity of CYP26B1
CTD PMID:14532297 PMID:21906690 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
JBrowse link
G Cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 multiple interactions ISO Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of alitretinoin]; Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of Tretinoin] CTD PMID:21906690 NCBI chr 1:235,458,961...235,468,433
Ensembl chr 1:235,459,356...235,466,842
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 decreases activity EXP Ketoconazole results in decreased activity of CYP27B1 protein CTD PMID:16483768 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects expression
increases expression
decreases activity
EXP Ketoconazole affects the expression of CYP2A1 mRNA
Ketoconazole results in increased expression of CYP2A1 protein
Ketoconazole results in decreased activity of CYP2A1 protein
CTD PMID:7986207 PMID:15879494 PMID:18355885 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 multiple interactions EXP Ketoconazole inhibits the reaction [CYP2A2 protein results in increased metabolism of 7-benzyloxyquinoline] CTD PMID:19858067 NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 decreases activity ISO Ketoconazole results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Ketoconazole inhibits the reaction [CYP2B1 protein results in increased metabolism of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19858067 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 affects expression EXP Ketoconazole affects the expression of CYP2B15 mRNA CTD PMID:18355885 NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
multiple interactions
increases expression
ISO Ketoconazole results in decreased activity of CYP2B6 protein
Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP2B6 mRNA]
Ketoconazole results in increased expression of CYP2B10 mRNA
Ketoconazole results in decreased activity of CYP2B10 protein
CTD PMID:14709627 PMID:16608920 PMID:17438109 PMID:17966066 PMID:18420780 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions
decreases activity
affects binding
decreases expression
EXP
ISO
Ketoconazole inhibits the reaction [CYP2C11 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
Ketoconazole results in decreased activity of CYP2C11 protein
Ketoconazole binds to CYP2C9 protein; Ketoconazole binds to CYP2C9 protein alternative form
Ketoconazole results in decreased activity of CYP2C9 protein
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP2C9 mRNA]
Ketoconazole results in decreased expression of CYP2C9 mRNA
CTD PMID:14709627 PMID:15618748 PMID:15879494 PMID:16081671 PMID:16608920 More... NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
decreases activity
EXP
ISO
Ketoconazole inhibits the reaction [CYP2C6V1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]
Ketoconazole results in decreased activity of CYP2C6V1 protein
Ketoconazole results in decreased activity of CYP2C19 protein
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
Ketoconazole results in decreased activity of CYP2C29 protein
CTD PMID:12814958 PMID:14709627 PMID:15618748 PMID:15879494 PMID:18420780 More... NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity
multiple interactions
ISO Ketoconazole results in decreased activity of CYP2C8 protein
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
CTD PMID:14709627 PMID:15601807 PMID:24120545
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 multiple interactions EXP Ketoconazole inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin] CTD PMID:19858067 NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases activity
decreases expression
ISO Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758]
Ketoconazole results in decreased activity of CYP2D6 protein
Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan]; Ketoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 mRNA]; Ketoconazole inhibits the reaction [Nicotine results in increased expression of CYP2D22 protein]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein]; Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]; Ketoconazole promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 protein]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 mRNA]; Nicotine inhibits the reaction [Ketoconazole results in decreased expression of CYP2D22 protein]
Ketoconazole results in decreased activity of CYP2D22 protein; Ketoconazole results in decreased activity of CYP2D6 protein
Ketoconazole results in decreased expression of CYP2D22 mRNA; Ketoconazole results in decreased expression of CYP2D22 protein
CTD PMID:15618748 PMID:16595712 PMID:18420780 PMID:19230594 PMID:19594327 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Ketoconazole results in decreased activity of CYP2E1 protein CTD PMID:15618748 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Ketoconazole results in decreased activity of CYP2J2 protein CTD PMID:12851038 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases metabolic processing
increases expression
increases response to substance
decreases expression
EXP
ISO
Ketoconazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline]; Ketoconazole inhibits the reaction [Phenytoin results in increased expression of CYP3A2 protein]
Ketoconazole results in decreased activity of CYP3A2 protein; Ketoconazole results in decreased activity of CYP3A4 protein
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Midazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Testosterone; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Triazolam; Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole affects the reaction [CYP3A4 polymorphism affects the metabolism of cabozantinib]; Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of acalabrutinib]; Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of vandetanib]; Ketoconazole binds to and results in decreased activity of CYP3A4 protein; Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with NADP] results in decreased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Testosterone] which results in increased chemical synthesis of Hydroxytestosterones]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Corticosterone results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Endosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Mefloquine]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]; Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased abundance of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of mono-N-demethyladinazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased susceptibility to Docetaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased abundance of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 11,12-epoxy-5,8,14-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 3'-p-hydroxypaclitaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of clozapine N-oxide]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of norclozapine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased degradation of Ticlopidine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased glutathionylation of dauricine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Carbofuran]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Metoprolol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of mono-N-desethylamiodarone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of nefazodone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of 8-epidiosbulbin E acetate]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of and results in decreased abundance of Quetiapine Fumarate]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Arachidonic Acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufalin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufogenin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cabozantinib]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of carbosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cinobufagin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of eldecalcitol]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Felodipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Terfenadine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Triazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 2-oxo-clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of dimemorfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Paclitaxel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Clopidogrel]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Endosulfan]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Ticlopidine]; Ketoconazole inhibits the reaction [erdafitinib results in decreased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]; Ketoconazole inhibits the reaction [U 0126 affects the activity of CYP3A4 protein]; Ketoconazole results in increased expression of and results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased metabolism of Ketoconazole
Ketoconazole results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased susceptibility to Ketoconazole
Ketoconazole results in decreased expression of CYP3A4 mRNA; Ketoconazole results in decreased expression of CYP3A4 protein
CTD PMID:9600717 PMID:10952769 PMID:10997946 PMID:11377097 PMID:11502731 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
affects expression
decreases activity
EXP [Strychnine co-treated with Ketoconazole] results in decreased expression of CYP3A23-3A1 protein; Ketoconazole inhibits the reaction [CYP3A23-3A1 protein results in increased metabolism of 7-benzyloxyquinoline]; Ketoconazole inhibits the reaction [Genistein results in increased expression of CYP3A23-3A1 mRNA]
Ketoconazole affects the expression of CYP3A23-3A1 mRNA
Ketoconazole results in decreased activity of CYP3A23-3A1 protein
CTD PMID:12814958 PMID:15879494 PMID:18355885 PMID:19858067 PMID:32185415 More... NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
decreases activity
affects response to substance
ISO CYP3A5 gene polymorphism affects the reaction [Ketoconazole results in decreased metabolism of Tacrolimus]; Ketoconazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Budesonide results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [erdafitinib results in decreased activity of CYP3A5 protein]; Ketoconazole inhibits the reaction [flunisolide results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Fluticasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Triamcinolone Acetonide results in increased expression of CYP3A5 mRNA]
Ketoconazole results in decreased activity of CYP3A5 protein
CYP3A5 gene polymorphism affects the susceptibility to Ketoconazole
CTD PMID:15557344 PMID:15731592 PMID:19384264 PMID:24555085 PMID:26302866 More... NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 increases expression EXP Ketoconazole results in increased expression of CYP4B1 mRNA CTD PMID:37077353 NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases activity ISO Ketoconazole results in decreased activity of CYP4F12 protein CTD PMID:14709627 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
JBrowse link
G Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 affects expression EXP Ketoconazole affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity
increases expression
increases activity
multiple interactions
decreases response to substance
ISO
EXP
Ketoconazole results in decreased activity of CYP51A1 protein
Ketoconazole results in increased expression of CYP51 mRNA; Ketoconazole results in increased expression of CYP51 protein
Ketoconazole results in increased activity of CYP51 protein
CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased metabolism of and results in increased abundance of Lanosterol]
[Ketoconazole results in increased activity of CYP51 protein] which results in increased abundance of Lanosterol
CYP51A1 gene results in decreased susceptibility to Ketoconazole
CTD PMID:12617470 PMID:16989930 PMID:17966066 PMID:18694951 PMID:28263823 More... NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
increases expression
EXP
ISO
[Chenodeoxycholic Acid co-treated with Ketoconazole] results in decreased expression of CYP7A1 mRNA
Ketoconazole results in increased expression of CYP7A1 mRNA
CTD PMID:30985903 PMID:31099283 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 affects expression EXP Ketoconazole affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr13:84,609,838...84,667,025
Ensembl chr13:84,610,248...84,669,726
JBrowse link
G Dcakd dephospho-CoA kinase domain containing increases expression EXP Ketoconazole results in increased expression of DCAKD mRNA CTD PMID:36653537 NCBI chr10:87,957,738...87,989,002
Ensembl chr10:87,957,740...87,980,054
JBrowse link
G Ddb1 damage-specific DNA binding protein 1 increases expression ISO Ketoconazole results in increased expression of DDB1 mRNA CTD PMID:36621641 NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
affects expression
ISO Ketoconazole results in increased expression of DDIT3 mRNA
EIF2S1 protein mutant form inhibits the reaction [Ketoconazole results in increased expression of DDIT3 mRNA]
Ketoconazole affects the expression of DDIT3 mRNA
CTD PMID:16330322 PMID:31099283 PMID:36621641 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Depp1 DEPP autophagy regulator 1 decreases expression
increases expression
ISO Ketoconazole results in decreased expression of DEPP1 mRNA
Ketoconazole results in increased expression of DEPP1 mRNA
CTD PMID:15342952 PMID:17175557 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
JBrowse link
G Desi2 desumoylating isopeptidase 2 decreases expression ISO Ketoconazole results in decreased expression of DESI2 mRNA CTD PMID:36621641 NCBI chr13:89,961,767...90,011,255
Ensembl chr13:89,961,934...90,016,416
JBrowse link
G Dgka diacylglycerol kinase, alpha decreases expression EXP Ketoconazole results in decreased expression of DGKA mRNA CTD PMID:37077353 NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases expression EXP
ISO
Ketoconazole results in increased expression of DHCR7 mRNA CTD PMID:28263823 PMID:36621641 PMID:36653537 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 increases expression EXP Ketoconazole results in increased expression of DHRS3 mRNA CTD PMID:37077353 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
JBrowse link
G Dhx9 DExH-box helicase 9 increases expression ISO Ketoconazole results in increased expression of DHX9 mRNA CTD PMID:36621641 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase decreases expression EXP Ketoconazole results in decreased expression of DLAT mRNA CTD PMID:37077353 NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein decreases expression EXP Ketoconazole results in decreased expression of DLC1 mRNA CTD PMID:36653537 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439
JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 decreases expression EXP Ketoconazole results in decreased expression of DLK1 mRNA CTD PMID:37077353 NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522
JBrowse link
G Dmc1 DNA meiotic recombinase 1 increases expression ISO Ketoconazole results in increased expression of DMC1 mRNA CTD PMID:16574651 NCBI chr 7:111,124,888...111,167,465
Ensembl chr 7:111,124,888...111,167,952
JBrowse link
G Dmxl1 Dmx-like 1 decreases expression ISO Ketoconazole results in decreased expression of DMXL1 mRNA CTD PMID:36621641 NCBI chr18:42,993,292...43,163,457
Ensembl chr18:42,993,340...43,163,456
JBrowse link
G Dnase1l1 deoxyribonuclease 1-like 1 decreases expression EXP Ketoconazole results in decreased expression of DNASE1L1 mRNA CTD PMID:36653537 NCBI chr  X:152,056,942...152,065,518
Ensembl chr  X:152,056,942...152,065,518
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha increases expression
decreases expression
EXP Ketoconazole results in increased expression of DNMT3A mRNA
Ketoconazole results in decreased expression of DNMT3A mRNA
CTD PMID:37077353 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression EXP Ketoconazole results in decreased expression of DNMT3B mRNA CTD PMID:37077353 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Dock1 dedicator of cyto-kinesis 1 decreases expression EXP Ketoconazole results in decreased expression of DOCK1 mRNA CTD PMID:36653537 NCBI chr 1:189,467,143...189,983,777
Ensembl chr 1:189,467,143...189,983,768
JBrowse link
G Dock6 dedicator of cytokinesis 6 increases expression EXP Ketoconazole results in increased expression of DOCK6 mRNA CTD PMID:36653537 NCBI chr 8:20,342,430...20,394,660
Ensembl chr 8:20,342,089...20,394,552
JBrowse link
G Dok7 docking protein 7 decreases expression ISO Ketoconazole results in decreased expression of DOK7 mRNA CTD PMID:36621641 NCBI chr14:75,665,444...75,699,413
Ensembl chr14:75,666,744...75,699,386
JBrowse link
G Dpcd deleted in primary ciliary dyskinesia increases expression ISO Ketoconazole results in increased expression of DPCD mRNA CTD PMID:36621641 NCBI chr 1:244,408,766...244,426,891
Ensembl chr 1:244,408,785...244,426,888
JBrowse link
G Drd4 dopamine receptor D4 decreases expression
multiple interactions
ISO Ketoconazole results in decreased expression of DRD4 mRNA
Ketoconazole inhibits the reaction [FSHB protein results in increased expression of DRD4 mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of DRD4 mRNA]
CTD PMID:19587329 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Drosha drosha ribonuclease III decreases expression EXP Ketoconazole results in decreased expression of DROSHA mRNA CTD PMID:36653537 NCBI chr 2:61,864,886...61,976,688
Ensembl chr 2:61,864,970...61,976,688
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression EXP Ketoconazole results in increased expression of DUSP1 mRNA CTD PMID:25787151 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Ednrb endothelin receptor type B increases expression EXP Ketoconazole results in increased expression of EDNRB mRNA CTD PMID:36653537 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Egf epidermal growth factor increases uptake
multiple interactions
ISO Ketoconazole results in increased uptake of EGF protein
Ketoconazole inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein]
CTD PMID:23125191 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
ISO
EXP
Ketoconazole inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein]
Ketoconazole results in decreased expression of EGFR mRNA
CTD PMID:23125191 PMID:37077353 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 increases expression EXP Ketoconazole results in increased expression of EGLN1 mRNA CTD PMID:37077353 NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression EXP Ketoconazole results in increased expression of EGLN3 mRNA CTD PMID:37077353 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
JBrowse link
G Eif1ad eukaryotic translation initiation factor 1A domain containing increases expression ISO Ketoconazole results in increased expression of EIF1AD mRNA CTD PMID:36621641 NCBI chr 1:202,674,362...202,679,662
Ensembl chr 1:202,674,185...202,679,658
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Ketoconazole inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2AK3 protein] CTD PMID:16330322 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO EIF2S1 protein mutant form inhibits the reaction [Ketoconazole results in increased expression of DDIT3 mRNA]; EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of IDI1 mRNA]; EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of MSMO1 mRNA] CTD PMID:16330322 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif3e eukaryotic translation initiation factor 3 subunit E decreases expression ISO Ketoconazole results in decreased expression of EIF3E mRNA CTD PMID:36621641 NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096
JBrowse link
G Eif3m eukaryotic translation initiation factor 3, subunit M increases expression ISO Ketoconazole results in increased expression of EIF3M mRNA CTD PMID:36621641 NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B affects expression EXP Ketoconazole affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr 7:133,206,637...133,228,436 JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases expression EXP Ketoconazole results in increased expression of EIF4EBP1 mRNA CTD PMID:37077353 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Elac1 elaC ribonuclease Z 1 increases expression EXP Ketoconazole results in increased expression of ELAC1 mRNA CTD PMID:36653537 NCBI chr18:67,321,231...67,341,358
Ensembl chr18:67,323,583...67,340,936
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 decreases expression ISO Ketoconazole results in decreased expression of ELOVL5 mRNA CTD PMID:36621641 NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 decreases expression EXP Ketoconazole results in decreased expression of ELOVL6 mRNA CTD PMID:37077353 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 decreases expression ISO Ketoconazole results in decreased expression of ENPP3 mRNA CTD PMID:31099283 NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041
JBrowse link
G Epas1 endothelial PAS domain protein 1 increases expression EXP
ISO
Ketoconazole results in increased expression of EPAS1 mRNA CTD PMID:36621641 PMID:37077353 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Epb41l3 erythrocyte membrane protein band 4.1-like 3 decreases expression EXP Ketoconazole results in decreased expression of EPB41L3 mRNA CTD PMID:36653537 NCBI chr 9:109,056,178...109,260,607
Ensembl chr 9:109,016,113...109,260,607
JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression
increases expression
EXP Ketoconazole affects the expression of EPHX1 mRNA
Ketoconazole results in increased expression of EPHX1 mRNA
CTD PMID:18355885 PMID:37077353 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Epo erythropoietin multiple interactions ISO Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of EPO mRNA]]; Ketoconazole inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] CTD PMID:21566342 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Eppin epididymal peptidase inhibitor multiple interactions
decreases expression
ISO Ketoconazole inhibits the reaction [FSHB protein results in increased expression of EPPIN mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of EPPIN mRNA] CTD PMID:19587329 NCBI chr 3:153,312,396...153,319,310
Ensembl chr 3:153,312,396...153,319,310
JBrowse link
G Eral1 Era-like 12S mitochondrial rRNA chaperone 1 decreases expression EXP Ketoconazole results in decreased expression of ERAL1 mRNA CTD PMID:36653537 NCBI chr10:62,961,725...62,968,747
Ensembl chr10:62,961,730...62,968,994
JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 decreases expression ISO Ketoconazole results in decreased expression of ERC1 mRNA CTD PMID:36621641 NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639
JBrowse link
G Ereg epiregulin increases expression ISO Ketoconazole results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha decreases expression EXP Ketoconazole results in decreased expression of ERO1A mRNA CTD PMID:37077353 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression EXP Ketoconazole affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 decreases expression ISO Ketoconazole results in decreased expression of ESCO2 mRNA CTD PMID:36621641 NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306
JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP Ketoconazole results in decreased expression of ESR1 mRNA CTD PMID:37077353 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esrra estrogen related receptor, alpha increases expression EXP Ketoconazole results in increased expression of ESRRA mRNA CTD PMID:37077353 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor decreases expression EXP Ketoconazole results in decreased expression of ETS1 mRNA CTD PMID:37077353 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
JBrowse link
G Exoc6b exocyst complex component 6B increases expression ISO Ketoconazole results in increased expression of EXOC6B mRNA CTD PMID:36621641 NCBI chr 4:117,094,741...117,550,221
Ensembl chr 4:117,094,741...117,550,180
JBrowse link
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit increases expression EXP Ketoconazole results in increased expression of EZH1 mRNA CTD PMID:37077353 NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit decreases expression EXP Ketoconazole results in decreased expression of EZH2 mRNA CTD PMID:37077353 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Ketoconazole results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO
EXP
Ketoconazole results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 PMID:36653537 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression EXP Ketoconazole results in increased expression of FABP3 mRNA CTD PMID:37077353 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression EXP Ketoconazole results in increased expression of FABP4 mRNA CTD PMID:37077353 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression EXP
ISO
Ketoconazole results in increased expression of FABP5 mRNA CTD PMID:31099283 PMID:37077353 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
JBrowse link
G Faf1 Fas associated factor 1 increases expression ISO
EXP
Ketoconazole results in increased expression of FAF1 mRNA CTD PMID:25808816 NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977
JBrowse link
G Fam20c FAM20C, golgi associated secretory pathway kinase increases expression EXP Ketoconazole results in increased expression of FAM20C mRNA CTD PMID:37077353 NCBI chr12:15,826,864...15,885,423
Ensembl chr12:15,826,871...15,884,543
JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions
ISO
EXP
Ketoconazole results in increased expression of FAS mRNA
Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of FAS protein]]
CTD PMID:15703382 PMID:25808816 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fbxl14 F-box and leucine-rich repeat protein 14 decreases expression EXP Ketoconazole results in decreased expression of FBXL14 mRNA CTD PMID:36653537 NCBI chr 4:152,662,542...152,666,360
Ensembl chr 4:152,662,542...152,666,360
JBrowse link
G Fbxl15 F-box and leucine-rich repeat protein 15 decreases expression ISO Ketoconazole results in decreased expression of FBXL15 mRNA CTD PMID:36621641 NCBI chr 1:245,189,732...245,191,973
Ensembl chr 1:245,189,736...245,192,007
JBrowse link
G Fbxo21 F-box protein 21 increases expression ISO Ketoconazole results in increased expression of FBXO21 mRNA CTD PMID:36621641 NCBI chr12:38,570,878...38,605,133
Ensembl chr12:38,571,023...38,605,133
JBrowse link
G Fbxw2 F-box and WD repeat domain containing 2 increases expression ISO Ketoconazole results in increased expression of FBXW2 mRNA CTD PMID:31099283 NCBI chr 3:18,088,859...18,114,387
Ensembl chr 3:18,088,865...18,114,381
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP Ketoconazole results in increased expression of FDFT1 mRNA CTD PMID:28263823 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression EXP Ketoconazole results in increased expression of FDPS mRNA CTD PMID:37077353 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Fdx1 ferredoxin 1 decreases expression EXP Ketoconazole results in decreased expression of FDX1 mRNA CTD PMID:36653537 NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414
JBrowse link
G Fezf1 Fez family zinc finger 1 decreases expression EXP Ketoconazole results in decreased expression of FEZF1 mRNA CTD PMID:37077353 NCBI chr 4:51,762,751...51,766,078
Ensembl chr 4:51,762,751...51,766,078
JBrowse link
G Fgfbp3 fibroblast growth factor binding protein 3 increases expression EXP Ketoconazole results in increased expression of FGFBP3 mRNA CTD PMID:28263823 NCBI chr 1:234,644,023...234,646,028
Ensembl chr 1:234,644,019...234,646,547
JBrowse link
G Flad1 flavin adenine dinucleotide synthetase 1 decreases expression ISO Ketoconazole results in decreased expression of FLAD1 mRNA CTD PMID:36621641 NCBI chr 2:174,819,451...174,828,921
Ensembl chr 2:174,819,453...174,828,977
JBrowse link
G Fn1 fibronectin 1 decreases expression EXP Ketoconazole results in decreased expression of FN1 mRNA CTD PMID:37077353 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Ketoconazole results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit decreases expression
increases expression
EXP
ISO
Ketoconazole results in decreased expression of FOSL1 mRNA
Ketoconazole results in increased expression of FOSL1 mRNA
CTD PMID:25787151 PMID:31099283 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Foxa2 forkhead box A2 increases expression EXP Ketoconazole results in increased expression of FOXA2 mRNA CTD PMID:37077353 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
JBrowse link
G Foxl2 forkhead box L2 increases expression ISO Ketoconazole results in increased expression of FOXL2 mRNA CTD PMID:36621641 NCBI chr 8:99,512,971...99,514,500
Ensembl chr 8:99,513,303...99,514,427
JBrowse link
G Foxp2 forkhead box P2 increases expression EXP Ketoconazole results in increased expression of FOXP2 mRNA CTD PMID:36653537 NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683
JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression ISO Ketoconazole results in decreased expression of FSCN1 mRNA CTD PMID:36621641 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Ketoconazole inhibits the reaction [FSHB protein results in increased expression of DRD4 mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of EPPIN mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of GPD1 mRNA]; Ketoconazole inhibits the reaction [FSHB protein results in increased expression of RHOX5 mRNA] CTD PMID:19587329 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Fyco1 FYVE and coiled-coil domain autophagy adaptor 1 increases expression
decreases expression
ISO
EXP
Ketoconazole results in increased expression of FYCO1 mRNA
Ketoconazole results in decreased expression of FYCO1 mRNA
CTD PMID:36621641 PMID:36653537 NCBI chr 8:123,412,105...123,479,315
Ensembl chr 8:123,412,112...123,479,021
JBrowse link
G G0s2 G0/G1switch 2 decreases expression ISO Ketoconazole results in decreased expression of G0S2 mRNA CTD PMID:36621641 NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 affects expression EXP Ketoconazole affects the expression of G6PC1 mRNA CTD PMID:18289764 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO Ketoconazole results in increased expression of G6PD mRNA CTD PMID:25399406 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gabarapl2 GABA type A receptor associated protein like 2 increases expression EXP Ketoconazole results in increased expression of GABARAPL2 mRNA CTD PMID:37077353 NCBI chr19:39,910,572...39,921,408
Ensembl chr19:39,910,534...39,924,628
Ensembl chr 8:39,910,534...39,924,628
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 increases expression EXP Ketoconazole results in increased expression of GABBR1 mRNA CTD PMID:37077353 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 increases expression EXP Ketoconazole results in increased expression of GABBR2 mRNA CTD PMID:37077353 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression EXP Ketoconazole results in increased expression of GABRA4 mRNA CTD PMID:37077353 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 decreases expression EXP Ketoconazole results in decreased expression of GABRA5 mRNA CTD PMID:37077353 NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta increases expression EXP Ketoconazole results in increased expression of GABRD mRNA CTD PMID:37077353 NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411
JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon decreases expression EXP Ketoconazole results in decreased expression of GABRE mRNA CTD PMID:37077353 NCBI chr  X:150,060,035...150,078,773
Ensembl chr  X:150,060,040...150,078,693
JBrowse link
G Gabrq gamma-aminobutyric acid type A receptor subunit theta decreases expression EXP Ketoconazole results in decreased expression of GABRQ mRNA CTD PMID:37077353 NCBI chr  X:150,696,161...150,712,948
Ensembl chr  X:150,696,427...150,709,919
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases expression ISO Ketoconazole results in decreased expression of GAD1 mRNA CTD PMID:31099283 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Ketoconazole results in increased expression of GADD45A mRNA CTD PMID:16483768 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression EXP Ketoconazole results in increased expression of GAPDH mRNA CTD PMID:37077353 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gata3 GATA binding protein 3 increases expression EXP Ketoconazole results in increased expression of GATA3 mRNA CTD PMID:37077353 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Gck glucokinase decreases expression EXP Ketoconazole results in decreased expression of GCK mRNA CTD PMID:37077353 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gckr glucokinase regulator affects expression EXP Ketoconazole affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
JBrowse link
G Gdi2 GDP dissociation inhibitor 2 increases expression ISO Ketoconazole results in increased expression of GDI2 mRNA CTD PMID:36621641 NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Ketoconazole results in increased expression of GDPD3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
JBrowse link
G Gfus GDP-L-fucose synthase increases expression ISO Ketoconazole results in increased expression of GFUS mRNA CTD PMID:36621641 NCBI chr 7:107,612,087...107,617,005
Ensembl chr 7:107,612,094...107,616,948
JBrowse link
G Ghr growth hormone receptor decreases expression EXP Ketoconazole results in decreased expression of GHR mRNA CTD PMID:37077353 NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression ISO Ketoconazole results in decreased expression of GJB1 mRNA CTD PMID:31099283 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression EXP Ketoconazole results in increased expression of GJB2 mRNA CTD PMID:36653537 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177
JBrowse link
G Gls2 glutaminase 2 affects expression EXP Ketoconazole affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr 7:617,252...633,424
Ensembl chr 7:617,288...633,426
JBrowse link
G Gnai1 G protein subunit alpha i1 increases expression EXP Ketoconazole results in increased expression of GNAI1 mRNA CTD PMID:37077353 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
JBrowse link
G Gng11 G protein subunit gamma 11 decreases expression ISO Ketoconazole results in decreased expression of GNG11 mRNA CTD PMID:36621641 NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442
JBrowse link
G Gnl3 G protein nucleolar 3 decreases expression ISO Ketoconazole results in decreased expression of GNL3 mRNA CTD PMID:36621641 NCBI chr16:6,207,402...6,213,491
Ensembl chr16:6,207,402...6,213,392
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 affects secretion EXP Ketoconazole affects the secretion of GNRH1 protein CTD PMID:37077353 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581
JBrowse link
G Golga3 golgin A3 decreases expression ISO Ketoconazole results in decreased expression of GOLGA3 mRNA CTD PMID:36621641 NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509
JBrowse link
G Golm1 golgi membrane protein 1 decreases expression ISO Ketoconazole results in decreased expression of GOLM1 mRNA CTD PMID:36621641 NCBI chr17:4,995,925...5,044,329
Ensembl chr17:4,996,104...5,034,057
JBrowse link
G Golph3l golgi phosphoprotein 3-like decreases expression ISO Ketoconazole results in decreased expression of GOLPH3L mRNA CTD PMID:36621641 NCBI chr 2:183,151,941...183,183,094
Ensembl chr 2:183,153,301...183,183,083
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO Ketoconazole results in increased expression of GOT1 protein CTD PMID:31099283 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 affects expression EXP Ketoconazole affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression EXP Ketoconazole results in decreased expression of GPAM mRNA CTD PMID:37077353 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Gpatch2 G patch domain containing 2 increases expression ISO Ketoconazole results in increased expression of GPATCH2 mRNA CTD PMID:36621641 NCBI chr13:98,784,993...98,925,696
Ensembl chr13:98,784,969...98,925,661
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 multiple interactions
decreases expression
increases expression
ISO
EXP
Ketoconazole inhibits the reaction [FSHB protein results in increased expression of GPD1 mRNA]; Metribolone inhibits the reaction [Ketoconazole results in decreased expression of GPD1 mRNA]
Ketoconazole results in increased expression of GPD1 mRNA
CTD PMID:19587329 PMID:37077353 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
JBrowse link
G Gpr12 G protein-coupled receptor 12 increases expression EXP Ketoconazole results in increased expression of GPR12 mRNA CTD PMID:37077353 NCBI chr12:8,522,709...8,525,875
Ensembl chr12:8,522,953...8,527,973
JBrowse link
G Gpr17 G protein-coupled receptor 17 decreases expression
increases expression
EXP Ketoconazole results in decreased expression of GPR17 mRNA
Ketoconazole results in increased expression of GPR17 mRNA
CTD PMID:37077353 NCBI chr18:23,576,232...23,583,153
Ensembl chr18:23,577,242...23,582,966
JBrowse link
G Gpr37 G protein-coupled receptor 37 increases expression EXP Ketoconazole results in increased expression of GPR37 mRNA CTD PMID:37077353 NCBI chr 4:54,138,860...54,160,927
Ensembl chr 4:54,138,870...54,161,001
JBrowse link
G Gpr6 G protein-coupled receptor 6 decreases expression ISO Ketoconazole results in decreased expression of GPR6 mRNA CTD PMID:31099283 NCBI chr20:44,489,853...44,492,624
Ensembl chr20:44,489,853...44,492,624
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression
EXP
ISO
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
Ketoconazole inhibits the reaction [columbin results in increased activity of GPT protein]; Ketoconazole promotes the reaction [gelsemine results in increased expression of GPT protein]
Ketoconazole results in increased expression of GPT protein
CTD PMID:31099283 PMID:31168027 PMID:32162908 PMID:34627953 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression EXP Ketoconazole results in increased expression of GPX4 mRNA CTD PMID:17679765 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression EXP Ketoconazole affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 increases expression ISO Ketoconazole results in increased expression of GREB1 mRNA CTD PMID:35307500 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G Grid2ip Grid2 interacting protein increases expression EXP Ketoconazole results in increased expression of GRID2IP mRNA CTD PMID:37077353 NCBI chr12:11,166,567...11,203,765
Ensembl chr12:11,167,874...11,203,676
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 decreases expression EXP Ketoconazole results in decreased expression of GRIK2 mRNA CTD PMID:37077353 NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375
JBrowse link
G Grina glutamate ionotropic receptor NMDA type subunit associated protein 1 increases expression ISO Ketoconazole results in increased expression of GRINA mRNA CTD PMID:36621641 NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366
JBrowse link
G Grm3 glutamate metabotropic receptor 3 increases expression EXP Ketoconazole results in increased expression of GRM3 mRNA CTD PMID:37077353 NCBI chr 4:24,364,854...24,643,972
Ensembl chr 4:24,365,115...24,609,804
JBrowse link
G Grm4 glutamate metabotropic receptor 4 affects expression EXP Ketoconazole affects the expression of GRM4 mRNA CTD PMID:37077353 NCBI chr20:5,484,172...5,572,821
Ensembl chr20:5,481,124...5,572,821
JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions
EXP Ketoconazole results in increased expression of GSR mRNA
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of GSR mRNA
CTD PMID:31168027 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
decreases expression
ISO
EXP
Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Rifampin results in increased expression of GSTA1 mRNA]
Ketoconazole results in decreased expression of GSTA1 mRNA
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTA1 mRNA]; Ketoconazole inhibits the reaction [Genistein results in increased expression of GSTA1 mRNA]
CTD PMID:16608920 PMID:31168027 PMID:32185415 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression ISO Ketoconazole results in decreased expression of GSTA2 mRNA CTD PMID:16608920 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO Ketoconazole results in increased expression of GSTM1 protein CTD PMID:17966066 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 affects expression EXP Ketoconazole affects the expression of GSTM2 mRNA CTD PMID:18289764 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac] CTD PMID:24246759 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gtpbp8 GTP-binding protein 8 (putative) decreases expression ISO Ketoconazole results in decreased expression of GTPBP8 mRNA CTD PMID:36621641 NCBI chr11:55,945,778...55,955,743
Ensembl chr11:55,945,795...55,955,635
JBrowse link
G Gzf1 GDNF-inducible zinc finger protein 1 increases expression EXP Ketoconazole results in increased expression of GZF1 mRNA CTD PMID:36653537 NCBI chr 3:136,119,004...136,131,223
Ensembl chr 3:136,119,113...136,131,223
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) decreases expression
increases expression
EXP
ISO
Ketoconazole results in decreased expression of H6PD mRNA
Ketoconazole results in increased expression of H6PD mRNA
CTD PMID:36621641 PMID:37077353 NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases expression
decreases expression
EXP
ISO
Ketoconazole results in increased expression of HADHA mRNA
Ketoconazole results in decreased expression of HADHA mRNA
CTD PMID:36621641 PMID:37077353 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression EXP Ketoconazole results in increased expression of HADHB mRNA CTD PMID:37077353 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
JBrowse link
G Hal histidine ammonia lyase affects expression EXP Ketoconazole affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
decreases expression
ISO Ketoconazole inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
Ketoconazole results in decreased expression of HAMP protein
CTD PMID:17966066 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Has2 hyaluronan synthase 2 increases expression ISO Ketoconazole results in increased expression of HAS2 mRNA CTD PMID:36621641 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 decreases expression EXP Ketoconazole results in decreased expression of HAVCR1 mRNA CTD PMID:18289764 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hbb hemoglobin subunit beta decreases expression EXP Ketoconazole results in decreased expression of HBB mRNA; Ketoconazole results in decreased expression of HBB-B1 mRNA CTD PMID:36653537 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
JBrowse link
G Hebp1 heme binding protein 1 increases expression EXP Ketoconazole results in increased expression of HEBP1 mRNA CTD PMID:37077353 NCBI chr 4:167,974,316...168,003,854
Ensembl chr 4:167,974,319...168,003,854
JBrowse link
G Hes6 hes family bHLH transcription factor 6 decreases expression EXP Ketoconazole results in decreased expression of HES6 mRNA CTD PMID:36653537 NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559
JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase increases expression ISO Ketoconazole results in increased expression of HIBADH mRNA CTD PMID:36621641 NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:81,649,175...81,780,617
JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor increases expression ISO Ketoconazole results in increased expression of HIF1AN mRNA CTD PMID:31099283 NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327
JBrowse link
G Hist1h4b histone cluster 1 H4 family member B decreases expression EXP Ketoconazole results in decreased expression of HIST1H4B mRNA CTD PMID:36653537 NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370
JBrowse link
G Hivep1 HIVEP zinc finger 1 increases expression ISO Ketoconazole results in increased expression of HIVEP1 mRNA CTD PMID:36621641 NCBI chr17:22,585,016...22,714,517
Ensembl chr17:22,585,016...22,711,956
JBrowse link
G Hmga2 high mobility group AT-hook 2 increases expression ISO Ketoconazole results in increased expression of HMGA2 mRNA CTD PMID:31099283 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G Hmgb2 high mobility group box 2 affects expression EXP Ketoconazole affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases activity
multiple interactions
decreases activity
decreases expression
increases expression
EXP
ISO
Ketoconazole results in increased activity of HMGCR protein
[Colforsin co-treated with Ketoconazole] results in decreased expression of HMGCR mRNA
Ketoconazole results in decreased activity of HMGCR protein
Ketoconazole results in decreased expression of HMGCR mRNA
Ketoconazole results in increased expression of HMGCR mRNA
CTD PMID:9199277 PMID:12617470 PMID:16935330 PMID:28263823 PMID:37077353 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP
ISO
Ketoconazole results in increased expression of HMGCS1 mRNA CTD PMID:28263823 PMID:31099283 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Ketoconazole results in decreased expression of HMGCS2 mRNA CTD PMID:31099283 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Hmox1 heme oxygenase 1 affects expression
multiple interactions
increases expression
EXP
ISO
Ketoconazole affects the expression of HMOX1 mRNA
Ketoconazole inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 protein; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]
Ketoconazole results in increased expression of HMOX1 mRNA
CTD PMID:12763371 PMID:18289764 PMID:22659318 PMID:31168027 PMID:37077353 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hormad1 HORMA domain containing 1 increases expression EXP Ketoconazole results in increased expression of HORMAD1 mRNA CTD PMID:36653537 NCBI chr 2:183,115,815...183,152,383
Ensembl chr 2:183,116,716...183,152,383
JBrowse link
G Hoxa4 homeo box A4 decreases expression ISO Ketoconazole results in decreased expression of HOXA4 mRNA CTD PMID:31099283 NCBI chr 4:81,289,677...81,291,685
Ensembl chr 4:81,289,682...81,291,685
JBrowse link
G Hpn hepsin increases expression ISO Ketoconazole results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases expression ISO Ketoconazole results in decreased expression of HRAS mRNA CTD PMID:36621641 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Ketoconazole results in decreased activity of HSD11B2 protein CTD PMID:10664531 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 multiple interactions ISO Ketoconazole promotes the reaction [Calcitriol results in increased expression of HSD17B2 mRNA] CTD PMID:12040012 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions
increases expression
ISO Ketoconazole promotes the reaction [Colforsin results in increased expression of HSD17B4 mRNA]
Ketoconazole results in increased expression of HSD17B4 mRNA
CTD PMID:16935330 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression EXP Ketoconazole results in increased expression of HSD17B7 mRNA CTD PMID:28263823 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP Ketoconazole results in decreased expression of HSD3B1 mRNA CTD PMID:17229994 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions
decreases expression
ISO [Colforsin co-treated with Ketoconazole] results in decreased expression of HSD3B2 mRNA
Ketoconazole results in decreased expression of HSD3B2 mRNA
CTD PMID:16935330 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 decreases expression EXP Ketoconazole results in decreased expression of HSPD1 mRNA CTD PMID:25787151 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Hyal2 hyaluronidase 2 increases expression ISO Ketoconazole results in increased expression of HYAL2 mRNA CTD PMID:36621641 NCBI chr 8:108,241,895...108,246,853
Ensembl chr 8:108,243,133...108,246,850
JBrowse link
G Hycc1 hyccin PI4KA lipid kinase complex subunit 1 decreases expression ISO Ketoconazole results in decreased expression of HYCC1 mRNA CTD PMID:36621641 NCBI chr 4:11,132,224...11,239,120
Ensembl chr 4:11,132,385...11,239,113
JBrowse link
G Ibsp integrin-binding sialoprotein multiple interactions ISO Ketoconazole inhibits the reaction [Calcifediol results in increased expression of IBSP mRNA] CTD PMID:21542014 NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693
JBrowse link
G Id4 inhibitor of DNA binding 4 increases expression ISO Ketoconazole results in increased expression of ID4 mRNA CTD PMID:36621641 NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression
multiple interactions
ISO
EXP
Ketoconazole results in increased expression of IDI1 mRNA
EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of IDI1 mRNA]
CTD PMID:16330322 PMID:28263823 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 increases expression EXP Ketoconazole results in increased expression of IFIH1 mRNA CTD PMID:36653537 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Ketoconazole results in increased expression of IGFBP1 mRNA CTD PMID:18289764 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 increases expression EXP Ketoconazole results in increased expression of IGFBP5 mRNA CTD PMID:36653537 PMID:37077353 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 increases expression EXP Ketoconazole results in increased expression of IGFBP6 mRNA CTD PMID:37077353 NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966
JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 increases expression EXP Ketoconazole results in increased expression of IGFBP7 mRNA CTD PMID:37077353 NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314
JBrowse link
G Ighe immunoglobulin heavy constant epsilon multiple interactions ISO Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA] CTD PMID:12230500
G Igkc immunoglobulin kappa constant decreases expression EXP Ketoconazole results in decreased expression of IGKC mRNA CTD PMID:18289764
G Igsf10 immunoglobulin superfamily, member 10 decreases expression EXP Ketoconazole results in decreased expression of IGSF10 mRNA CTD PMID:37077353 NCBI chr 2:143,575,710...143,605,044
Ensembl chr 2:143,576,070...143,604,773
JBrowse link
G Ihh Indian hedgehog signaling molecule increases expression EXP Ketoconazole results in increased expression of IHH mRNA CTD PMID:37077353 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Ketoconazole results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA2 mRNA]; Ketoconazole promotes the reaction [gelsemine results in increased expression of IL1B protein]
Ketoconazole results in increased expression of IL1B mRNA
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]
CTD PMID:17966066 PMID:28138970 PMID:31168027 PMID:32816093 PMID:34627953 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 multiple interactions ISO Ketoconazole promotes the reaction [Calcitriol results in increased expression of IL1RL1 mRNA] CTD PMID:12040012 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Il24 interleukin 24 increases expression ISO Ketoconazole results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il33 interleukin 33 affects expression
increases expression
EXP Ketoconazole affects the expression of IL33 mRNA
Ketoconazole results in increased expression of IL33 mRNA
CTD PMID:18355885 PMID:37077353 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases secretion
decreases expression
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]]; Bucladesine inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL4 protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Ketoconazole inhibits the reaction [IL4 protein results in increased chemical synthesis of Cyclic AMP]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; Ketoconazole inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]; Ketoconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone] CTD PMID:11886533 PMID:12230500 PMID:15284827 PMID:23688403 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions
decreases expression
decreases secretion
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Ketoconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Ketoconazole results in decreased secretion of IL5 protein] CTD PMID:11886533 PMID:15284827 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA1 mRNA]; Ketoconazole inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of SAA2 mRNA]; Ketoconazole inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]
CTD PMID:17966066 PMID:31168027 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ing1 inhibitor of growth family, member 1 decreases expression ISO Ketoconazole results in decreased expression of ING1 mRNA CTD PMID:36621641 NCBI chr16:77,937,276...77,945,320
Ensembl chr16:77,937,279...77,946,264
JBrowse link
G Ing2 inhibitor of growth family, member 2 decreases expression ISO Ketoconazole results in decreased expression of ING2 mRNA CTD PMID:36621641 NCBI chr16:44,573,592...44,584,180
Ensembl chr16:44,575,597...44,583,482
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Ketoconazole results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
JBrowse link
G Inip INTS3 and NABP interacting protein increases expression EXP Ketoconazole results in increased expression of INIP mRNA CTD PMID:36653537 NCBI chr 5:74,648,392...74,662,628
Ensembl chr 5:74,648,392...74,662,628
JBrowse link
G Insig1 insulin induced gene 1 increases expression EXP Ketoconazole results in increased expression of INSIG1 mRNA CTD PMID:37077353 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Insl3 insulin-like 3 decreases expression EXP Ketoconazole results in decreased expression of INSL3 mRNA CTD PMID:36653537 NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560
JBrowse link
G Insr insulin receptor decreases expression EXP Ketoconazole results in decreased expression of INSR mRNA CTD PMID:37077353 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Ipo5 importin 5 decreases expression ISO Ketoconazole results in decreased expression of IPO5 mRNA CTD PMID:36621641 NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126
JBrowse link
G Ipo7 importin 7 increases expression ISO Ketoconazole results in increased expression of IPO7 mRNA CTD PMID:36621641 NCBI chr 1:164,062,702...164,102,938
Ensembl chr 1:164,062,702...164,102,938
JBrowse link
G Irs1 insulin receptor substrate 1 decreases expression EXP Ketoconazole results in decreased expression of IRS1 mRNA CTD PMID:37077353 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression EXP Ketoconazole results in increased expression of ITPR1 mRNA CTD PMID:37077353 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Ivd isovaleryl-CoA dehydrogenase increases expression EXP Ketoconazole results in increased expression of IVD mRNA CTD PMID:37077353 NCBI chr 3:105,851,710...105,872,144
Ensembl chr 3:105,851,683...105,872,575
JBrowse link
G Kcmf1 potassium channel modulatory factor 1 increases expression ISO Ketoconazole results in increased expression of KCMF1 mRNA CTD PMID:36621641 NCBI chr 4:104,888,452...104,950,234
Ensembl chr 4:104,889,847...104,950,234
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 decreases activity ISO Ketoconazole results in decreased activity of KCNA5 protein CTD PMID:9694927 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 increases expression EXP Ketoconazole results in increased expression of KCNE2 mRNA CTD PMID:36653537 NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043
JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 decreases expression EXP Ketoconazole results in decreased expression of KCNH1 mRNA CTD PMID:36653537 NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity
affects localization
decreases activity
multiple interactions
decreases response to substance
ISO Ketoconazole affects the activity of KCNH2 protein mutant form
Ketoconazole affects the localization of KCNH2; Ketoconazole affects the localization of KCNH2 protein mutant form
Ketoconazole results in decreased activity of KCNH2; Ketoconazole results in decreased activity of KCNH2 protein
[Ketoconazole co-treated with desloratadine co-treated with Loratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with desloratadine] results in decreased activity of KCNH2 protein; [Ketoconazole co-treated with Loratadine] results in decreased activity of KCNH2 protein; Ketoconazole binds to and results in decreased activity of KCNH2 protein; Terfenadine promotes the reaction [Ketoconazole results in decreased activity of KCNH2 protein]
KCNH2 protein mutant form results in decreased susceptibility to Ketoconazole
CTD PMID:9694927 PMID:15272206 PMID:16542653 PMID:17965736 PMID:24052561 More... NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 decreases expression EXP Ketoconazole results in decreased expression of KCTD12 mRNA CTD PMID:37077353 NCBI chr15:79,800,078...79,806,017
Ensembl chr15:79,801,191...79,806,282
JBrowse link
G Kctd12b potassium channel tetramerisation domain containing 12b decreases expression EXP Ketoconazole results in decreased expression of KCTD12B mRNA CTD PMID:37077353 NCBI chr  X:17,643,707...17,654,820
Ensembl chr  X:17,643,615...17,654,820
JBrowse link
G Kdm2b lysine demethylase 2B affects expression ISO Ketoconazole affects the expression of KDM2B mRNA CTD PMID:36621641 NCBI chr12:33,566,530...33,701,366
Ensembl chr12:33,574,657...33,701,355
JBrowse link
G Kdm3a lysine demethylase 3A increases expression EXP Ketoconazole results in increased expression of KDM3A mRNA CTD PMID:36653537 NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression EXP Ketoconazole results in increased expression of KEAP1 mRNA CTD PMID:37077353 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Klf11 KLF transcription factor 11 decreases expression EXP Ketoconazole results in decreased expression of KLF11 mRNA CTD PMID:37077353 NCBI chr 6:41,285,699...41,297,548
Ensembl chr 6:41,285,842...41,297,550
JBrowse link
G Klk1 kallikrein 1 increases expression ISO Ketoconazole results in increased expression of KLK1 mRNA CTD PMID:31099283 NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754
JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 multiple interactions ISO [Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of KLK3 protein CTD PMID:24323034 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
JBrowse link
G Klk6 kallikrein related-peptidase 6 multiple interactions
increases expression
ISO
EXP
Ketoconazole promotes the reaction [Calcitriol results in increased expression of KLK6 mRNA]
Ketoconazole results in increased expression of KLK6 mRNA
CTD PMID:26485663 PMID:37077353 NCBI chr 1:94,278,863...94,286,136
Ensembl chr 1:94,280,340...94,286,121
JBrowse link
G Kpna3 karyopherin subunit alpha 3 increases expression ISO Ketoconazole results in increased expression of KPNA3 mRNA CTD PMID:36621641 NCBI chr15:35,536,310...35,610,066
Ensembl chr15:35,536,316...35,610,419
JBrowse link
G Lamb3 laminin subunit beta 3 increases expression EXP Ketoconazole results in increased expression of LAMB3 mRNA CTD PMID:37077353 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
JBrowse link
G Laptm4a lysosomal protein transmembrane 4 alpha increases expression EXP Ketoconazole results in increased expression of LAPTM4A mRNA CTD PMID:37077353 NCBI chr 6:31,719,287...31,737,023
Ensembl chr 6:31,718,976...31,737,020
JBrowse link
G Lcn2 lipocalin 2 decreases expression EXP Ketoconazole results in decreased expression of LCN2 mRNA CTD PMID:18289764 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Ketoconazole inhibits the reaction [LHB protein results in increased abundance of Testosterone] CTD PMID:7589908 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP Ketoconazole results in decreased expression of LHCGR mRNA CTD PMID:36653537 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Lhpp phospholysine phosphohistidine inorganic pyrophosphate phosphatase increases expression EXP Ketoconazole results in increased expression of LHPP mRNA CTD PMID:37077353 NCBI chr 1:187,403,390...187,494,577
Ensembl chr 1:187,403,433...187,494,578
JBrowse link
G Lhx1 LIM homeobox 1 increases expression EXP Ketoconazole results in increased expression of LHX1 mRNA CTD PMID:28263823 NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617
JBrowse link
G Lmnb1 lamin B1 decreases expression ISO Ketoconazole results in decreased expression of LMNB1 mRNA CTD PMID:36621641 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502
JBrowse link
G Lnpk lunapark, ER junction formation factor increases expression ISO Ketoconazole results in increased expression of LNPK mRNA CTD PMID:36621641 NCBI chr 3:59,418,872...59,487,029
Ensembl chr 3:59,424,286...59,486,518
JBrowse link
G Lox lysyl oxidase affects expression EXP Ketoconazole affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Lrrc17 leucine rich repeat containing 17 decreases expression ISO Ketoconazole results in decreased expression of LRRC17 mRNA CTD PMID:36621641 NCBI chr 4:13,501,428...13,531,845
Ensembl chr 4:13,501,436...13,531,845
JBrowse link
G Lrrc28 leucine rich repeat containing 28 decreases expression EXP Ketoconazole results in decreased expression of LRRC28 mRNA CTD PMID:36653537 NCBI chr 1:121,116,833...121,245,805
Ensembl chr 1:121,127,733...121,245,784
JBrowse link
G Lrrc41 leucine rich repeat containing 41 decreases expression ISO Ketoconazole results in decreased expression of LRRC41 mRNA CTD PMID:36621641 NCBI chr 5:129,554,547...129,575,450
Ensembl chr 5:129,554,547...129,575,449
JBrowse link
G Lrrc75a leucine rich repeat containing 75A increases expression EXP Ketoconazole results in increased expression of LRRC75A mRNA CTD PMID:28263823 NCBI chr10:47,298,222...47,343,301
Ensembl chr10:47,297,288...47,343,664
JBrowse link
G Lrrfip2 LRR binding FLII interacting protein 2 decreases expression ISO Ketoconazole results in decreased expression of LRRFIP2 mRNA CTD PMID:36621641 NCBI chr 8:111,091,453...111,193,947
Ensembl chr 8:111,091,503...111,193,255
JBrowse link
G Lsm5 LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated increases expression ISO Ketoconazole results in increased expression of LSM5 mRNA CTD PMID:36621641 NCBI chr 4:85,951,073...85,954,289
Ensembl chr 6:104,652,477...104,654,165
Ensembl chr 4:104,652,477...104,654,165
JBrowse link
G Lss lanosterol synthase increases expression ISO Ketoconazole results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G M6pr mannose-6-phosphate receptor, cation dependent decreases expression ISO Ketoconazole results in decreased expression of M6PR mRNA CTD PMID:36621641 NCBI chr 4:155,501,080...155,510,219
Ensembl chr 4:155,500,921...155,510,216
JBrowse link
G Macroh2a1 macroH2A.1 histone affects expression EXP Ketoconazole affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072
JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 multiple interactions ISO Ketoconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] CTD PMID:12388057 NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703
JBrowse link
G Malsu1 mitochondrial assembly of ribosomal large subunit 1 increases expression ISO Ketoconazole results in increased expression of MALSU1 mRNA CTD PMID:36621641 NCBI chr 4:78,051,090...78,059,913
Ensembl chr 4:78,051,059...78,059,905
JBrowse link
G Manba mannosidase beta affects expression EXP Ketoconazole affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 2:223,910,432...224,002,988
Ensembl chr 2:223,910,432...224,002,983
JBrowse link
G Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 decreases expression ISO Ketoconazole results in decreased expression of MAP4K5 mRNA CTD PMID:36621641 NCBI chr 6:88,284,087...88,377,118
Ensembl chr 6:88,284,094...88,376,799
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression ISO Ketoconazole results in decreased expression of MAPK14 mRNA CTD PMID:36621641 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
increases expression
ISO
EXP
Ketoconazole results in increased phosphorylation of MAPK8 protein
Ketoconazole results in increased expression of MAPK8 mRNA
CTD PMID:19631732 PMID:25787151 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mbnl1 muscleblind-like splicing regulator 1 decreases expression EXP Ketoconazole results in decreased expression of MBNL1 mRNA CTD PMID:37077353 NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368
JBrowse link
G Mc3r melanocortin 3 receptor decreases expression EXP Ketoconazole results in decreased expression of MC3R mRNA CTD PMID:37077353 NCBI chr 3:161,016,347...161,017,444
Ensembl chr 3:161,016,347...161,017,444
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein CTD PMID:31629065 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 increases expression EXP Ketoconazole results in increased expression of MCM7 mRNA CTD PMID:37077353 NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063
JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression EXP Ketoconazole results in increased expression of MDH1 mRNA CTD PMID:37077353 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
JBrowse link
G Me1 malic enzyme 1 increases expression EXP Ketoconazole results in increased expression of ME1 mRNA CTD PMID:37077353 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Ketoconazole results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mfn1 mitofusin 1 increases expression ISO Ketoconazole results in increased expression of MFN1 mRNA CTD PMID:36621641 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
JBrowse link
G Mgll monoglyceride lipase increases expression EXP Ketoconazole results in increased expression of MGLL mRNA CTD PMID:37077353 NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179
JBrowse link
G Mgp matrix Gla protein affects expression EXP Ketoconazole affects the expression of MGP mRNA CTD PMID:18289764 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression EXP Ketoconazole results in increased expression of MGST1 mRNA CTD PMID:37077353 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 increases expression ISO Ketoconazole results in increased expression of MGST2 mRNA CTD PMID:36621641 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
JBrowse link
G Micb MHC class I polypeptide-related sequence B increases expression ISO Ketoconazole results in increased expression of MICB mRNA CTD PMID:32060585 NCBI chr 1:78,495,779...78,513,030
Ensembl chr 1:78,495,779...78,512,827
JBrowse link
G Micu1 mitochondrial calcium uptake 1 increases expression ISO Ketoconazole results in increased expression of MICU1 mRNA CTD PMID:36621641 NCBI chr20:27,668,681...27,816,322
Ensembl chr20:27,668,747...27,814,964
JBrowse link
G Mill1 MHC I like leukocyte 1 increases expression ISO Ketoconazole results in increased expression of MICA mRNA CTD PMID:32060585 NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:78,372,802...78,398,930
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression ISO Ketoconazole results in increased expression of MKI67 mRNA CTD PMID:25808816 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mkrn3 makorin, ring finger protein, 3 decreases expression EXP Ketoconazole results in decreased expression of MKRN3 mRNA CTD PMID:37077353 NCBI chr 1:115,926,774...115,929,288
Ensembl chr 1:115,926,776...115,929,283
JBrowse link
G Mlx MAX dimerization protein MLX affects expression EXP Ketoconazole affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr10:86,019,216...86,024,326
Ensembl chr10:86,019,588...86,032,350
JBrowse link
G Mlycd malonyl-CoA decarboxylase increases expression EXP Ketoconazole results in increased expression of MLYCD mRNA CTD PMID:37077353 NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793
JBrowse link
G Mmab metabolism of cobalamin associated B increases expression ISO Ketoconazole results in increased expression of MMAB mRNA CTD PMID:36621641 NCBI chr12:42,159,109...42,172,518
Ensembl chr12:42,159,089...42,172,490
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression EXP Ketoconazole results in decreased expression of MMP14 mRNA CTD PMID:37077353 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mpzl1 myelin protein zero-like 1 decreases expression ISO Ketoconazole results in decreased expression of MPZL1 mRNA CTD PMID:36621641 NCBI chr13:77,852,467...77,889,305
Ensembl chr13:77,852,467...77,896,616
JBrowse link
G Mrap2 melanocortin 2 receptor accessory protein 2 increases expression EXP Ketoconazole results in increased expression of MRAP2 mRNA CTD PMID:36653537 NCBI chr 8:88,088,293...88,144,636
Ensembl chr 8:88,088,272...88,143,886
JBrowse link
G Mras muscle RAS oncogene homolog increases expression ISO Ketoconazole results in increased expression of MRAS mRNA CTD PMID:36621641 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408
JBrowse link
G mrpl11 mitochondrial ribosomal protein L11 decreases expression ISO Ketoconazole results in decreased expression of MRPL11 mRNA CTD PMID:36621641 NCBI chr 1:202,264,419...202,267,288
Ensembl chr 1:202,264,471...202,267,756
JBrowse link
G Mrpl18 mitochondrial ribosomal protein L18 increases expression ISO Ketoconazole results in increased expression of MRPL18 mRNA CTD PMID:36621641 NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987
JBrowse link
G Mrpl32 mitochondrial ribosomal protein L32 increases expression ISO Ketoconazole results in increased expression of MRPL32 mRNA CTD PMID:36621641 NCBI chr17:50,565,133...50,568,000
Ensembl chr17:50,565,055...50,568,010
JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B affects expression EXP Ketoconazole affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr20:2,838,174...2,844,260
Ensembl chr20:2,838,030...2,844,260
JBrowse link
G Mrps30 mitochondrial ribosomal protein S30 decreases expression ISO Ketoconazole results in decreased expression of MRPS30 mRNA CTD PMID:36621641 NCBI chr 2:50,456,253...50,463,128
Ensembl chr 2:50,456,255...50,463,105
JBrowse link
G Mrps31 mitochondrial ribosomal protein S31 increases expression ISO Ketoconazole results in increased expression of MRPS31 mRNA CTD PMID:36621641 NCBI chr16:69,601,349...69,621,609
Ensembl chr16:69,601,349...69,630,654
JBrowse link
G Mrto4 MRT4 homolog, ribosome maturation factor increases expression EXP Ketoconazole results in increased expression of MRTO4 mRNA CTD PMID:37077353 NCBI chr 5:151,601,780...151,608,533
Ensembl chr 5:151,601,780...151,608,287
JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects expression
multiple interactions
increases expression
EXP
ISO
Ketoconazole affects the expression of MSMO1 mRNA
EIF2S1 protein mutant form promotes the reaction [Ketoconazole results in increased expression of MSMO1 mRNA]
CTD PMID:16330322 PMID:18355885 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
JBrowse link
G Msn moesin increases expression EXP Ketoconazole results in increased expression of MSN mRNA CTD PMID:36653537 NCBI chr  X:60,996,043...61,064,011
Ensembl chr  X:60,995,951...61,065,628
JBrowse link
G Mt1 metallothionein 1 increases expression EXP Ketoconazole results in increased expression of MT1A mRNA CTD PMID:18289764 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
JBrowse link
G Mtch2 mitochondrial carrier 2 increases expression ISO Ketoconazole results in increased expression of MTCH2 mRNA CTD PMID:36621641 NCBI chr 3:76,830,549...76,850,189
Ensembl chr 3:76,830,413...76,850,189
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like decreases expression ISO Ketoconazole results in decreased expression of MTHFD1L mRNA CTD PMID:36621641 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905
JBrowse link
G Mtmr2 myotubularin related protein 2 decreases expression ISO Ketoconazole results in decreased expression of MTMR2 mRNA CTD PMID:36621641 NCBI chr 8:10,617,993...10,670,724
Ensembl chr 8:10,617,993...10,668,172
JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression EXP Ketoconazole results in increased expression of MVD mRNA CTD PMID:37077353 NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression EXP Ketoconazole results in increased expression of MYD88 mRNA CTD PMID:37077353 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Myh14 myosin heavy chain 14 increases expression EXP Ketoconazole results in increased expression of MYH14 mRNA CTD PMID:37077353 NCBI chr 1:95,096,266...95,158,861
Ensembl chr 1:95,096,266...95,158,836
JBrowse link
G Myh7 myosin heavy chain 7 decreases expression EXP Ketoconazole results in decreased expression of MYH7 mRNA CTD PMID:37077353 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Myt1 myelin transcription factor 1 increases expression ISO Ketoconazole results in increased expression of MYT1 mRNA CTD PMID:31099283 NCBI chr 3:168,890,466...168,950,341
Ensembl chr 3:168,886,089...168,950,341
JBrowse link
G Nasp nuclear autoantigenic sperm protein increases expression ISO Ketoconazole results in increased expression of NASP mRNA CTD PMID:36621641 NCBI chr 5:130,057,363...130,083,003
Ensembl chr 5:130,057,363...130,082,928
JBrowse link
G Ncbp2as2 NCBP2 antisense 2 (head to head) increases expression ISO Ketoconazole results in increased expression of NCBP2AS2 mRNA CTD PMID:36621641 NCBI chr11:68,829,950...68,830,715
Ensembl chr11:68,829,983...68,830,708
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression
increases expression
EXP Ketoconazole results in decreased expression of NCF1 mRNA
Ketoconazole results in increased expression of NCF1 mRNA
CTD PMID:25787151 PMID:37077353 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Ketoconazole inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOA1 protein]; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]] CTD PMID:12072427 PMID:16819505 PMID:17438109 PMID:17998298 PMID:23525103 More... NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO Ketoconazole inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOR2 protein] CTD PMID:12072427 PMID:29356861 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319
JBrowse link
G Ncr3lg1 natural killer cell cytotoxicity receptor 3 ligand 1 increases expression ISO Ketoconazole results in increased expression of NCR3LG1 mRNA; Ketoconazole results in increased expression of NCR3LG1 protein CTD PMID:32060585 NCBI chr 1:96,565,664...96,581,825
Ensembl chr 1:96,574,455...96,580,466
JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression EXP Ketoconazole results in increased expression of NDRG1 mRNA CTD PMID:37077353 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 increases expression EXP Ketoconazole results in increased expression of NDUFA5 mRNA CTD PMID:37077353 NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
JBrowse link
G Neil2 nei-like DNA glycosylase 2 increases expression ISO Ketoconazole results in increased expression of NEIL2 mRNA CTD PMID:36621641 NCBI chr15:37,444,676...37,454,863
Ensembl chr15:37,445,381...37,454,863
JBrowse link
G Net1 neuroepithelial cell transforming 1 increases expression ISO Ketoconazole results in increased expression of NET1 mRNA CTD PMID:36621641 NCBI chr17:66,341,251...66,370,445
Ensembl chr17:66,340,728...66,370,441
JBrowse link
G Neto1 neuropilin and tolloid like 1 decreases expression EXP Ketoconazole results in decreased expression of NETO1 mRNA CTD PMID:37077353 NCBI chr18:79,635,633...79,753,913
Ensembl chr18:79,635,633...79,749,030
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
ISO
EXP
[Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]
Ketoconazole results in increased expression of NFE2L2 mRNA; Ketoconazole results in increased expression of NFE2L2 protein
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of NFE2L2 protein
CTD PMID:21753779 PMID:31168027 PMID:37077353 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein] CTD PMID:23688403 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngfr nerve growth factor receptor increases expression EXP Ketoconazole results in increased expression of NGFR mRNA CTD PMID:28263823 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Niban1 niban apoptosis regulator 1 decreases expression EXP Ketoconazole results in decreased expression of NIBAN1 mRNA CTD PMID:36653537 NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729
JBrowse link
G Niban2 niban apoptosis regulator 2 decreases expression ISO Ketoconazole results in decreased expression of NIBAN2 mRNA CTD PMID:36621641 NCBI chr 3:16,174,674...16,224,293
Ensembl chr 3:16,174,659...16,224,293
JBrowse link
G Ninj1 ninjurin 1 increases expression ISO Ketoconazole results in increased expression of NINJ1 mRNA CTD PMID:36621641 NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Ketoconazole results in increased expression of NLRP3 mRNA CTD PMID:28138970 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression EXP Ketoconazole results in decreased expression of NOS3 mRNA CTD PMID:37077353 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Npm2 nucleophosmin/nucleoplasmin 2 increases expression EXP Ketoconazole results in increased expression of NPM2 mRNA CTD PMID:36653537 NCBI chr15:45,722,282...45,729,336
Ensembl chr15:45,722,400...45,729,726
JBrowse link
G Npr3 natriuretic peptide receptor 3 decreases expression EXP Ketoconazole results in decreased expression of NPR3 mRNA CTD PMID:37077353 NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
JBrowse link
G Npw neuropeptide W decreases expression EXP Ketoconazole results in decreased expression of NPW mRNA CTD PMID:37077353 NCBI chr10:13,680,275...13,681,618
Ensembl chr10:13,680,321...13,681,586
JBrowse link
G Npy2r neuropeptide Y receptor Y2 decreases expression EXP Ketoconazole results in decreased expression of NPY2R mRNA CTD PMID:37077353 NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO
EXP
Ketoconazole results in increased expression of NQO1 mRNA; Ketoconazole results in increased expression of NQO1 protein
AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Ketoconazole results in increased expression of NQO1 protein]; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of NQO1 mRNA]
[Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of NQO1 mRNA
CTD PMID:17923278 PMID:21753779 PMID:31168027 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Ketoconazole results in increased expression of NR0B2 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression EXP Ketoconazole results in increased expression of NR1D1 mRNA CTD PMID:37077353 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions
increases expression
ISO
EXP
Ketoconazole inhibits the reaction [T0901317 results in increased activity of NR1H2 protein]
Ketoconazole results in increased expression of NR1H2 mRNA
CTD PMID:16819505 PMID:37077353 NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions EXP
ISO
Ketoconazole inhibits the reaction [Clofibrate results in increased expression of NR1H3 mRNA]
Ketoconazole inhibits the reaction [T0901317 results in increased activity of NR1H3 protein]
CTD PMID:14690017 PMID:16819505 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Ketoconazole inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:16819505 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
decreases expression
decreases response to substance
ISO [Ketoconazole co-treated with Rifampin] results in increased activity of NR1I2 protein; Ketoconazole binds to and results in decreased activity of NR1I2 protein; Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NCOR2 protein binds to NR1I2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOA1 protein]; Ketoconazole inhibits the reaction [NR1I2 protein binds to NCOR2 protein]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [piperine results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of ABCB1 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [NR1I2 protein promotes the reaction [Rifampin results in increased expression of CYP3A4 protein]]; Ketoconazole inhibits the reaction [NR1I2 protein results in decreased uptake of and results in decreased metabolism of Glucose]; Ketoconazole inhibits the reaction [Paclitaxel promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Paclitaxel results in increased activity of NR1I2 protein]; Ketoconazole inhibits the reaction [piperine promotes the reaction [NCOA1 protein binds to NR1I2 protein]]; Ketoconazole inhibits the reaction [Rifampin binds to and results in increased activity of NR1I2 protein]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Ketoconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]
Ketoconazole results in increased activity of NR1I2 protein
Ketoconazole results in decreased expression of NR1I2 mRNA; Ketoconazole results in decreased expression of NR1I2 protein
Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein]
NR1I2 protein mutant form results in decreased susceptibility to Ketoconazole
CTD PMID:12072427 PMID:16608920 PMID:16819505 PMID:17438109 PMID:17998298 More... NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases activity
decreases expression
ISO [Ketoconazole co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; Ketoconazole binds to and results in decreased activity of NR1I3 protein alternative form; Ketoconazole inhibits the reaction [Dexamethasone results in increased expression of NR1I3 mRNA]; Ketoconazole inhibits the reaction [Phenobarbital results in increased activity of NR1I3 protein]
Ketoconazole results in decreased activity of NR1I3 protein
Ketoconazole results in decreased expression of NR1I3 mRNA
Ketoconazole inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein]
CTD PMID:16608920 PMID:16819505 PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 increases expression ISO Ketoconazole results in increased expression of NR2F1 mRNA CTD PMID:36621641 NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding
decreases activity
multiple interactions
ISO Ketoconazole binds to NR3C1 protein
Ketoconazole results in decreased activity of NR3C1 protein
Ketoconazole inhibits the reaction [Dexamethasone binds to and results in increased activity of NR3C1 protein]
CTD PMID:15755314 PMID:16608920 PMID:25000292 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 decreases expression EXP Ketoconazole results in decreased expression of NR5A1 mRNA CTD PMID:37077353 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328
JBrowse link
G Nrep neuronal regeneration related protein affects expression EXP Ketoconazole affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591
JBrowse link
G Nrip3 nuclear receptor interacting protein 3 increases expression EXP Ketoconazole results in increased expression of NRIP3 mRNA CTD PMID:36653537 NCBI chr 1:163,789,738...163,815,036
Ensembl chr 1:163,789,738...163,815,600
JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like increases expression EXP Ketoconazole results in increased expression of NSDHL mRNA CTD PMID:28263823 NCBI chr  X:150,775,034...150,807,161
Ensembl chr  X:150,775,080...150,807,142
JBrowse link
G Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor increases expression EXP Ketoconazole results in increased expression of NSMF mRNA CTD PMID:37077353 NCBI chr 3:7,861,846...7,870,615
Ensembl chr 3:7,861,872...7,870,614
JBrowse link
G Ntng1 netrin G1 decreases expression ISO Ketoconazole results in decreased expression of NTNG1 mRNA CTD PMID:31099283 NCBI chr 2:197,462,785...197,827,681
Ensembl chr 2:197,463,945...197,826,997
JBrowse link
G Nub1 negative regulator of ubiquitin-like proteins 1 increases expression ISO Ketoconazole results in increased expression of NUB1 mRNA CTD PMID:36621641 NCBI chr 4:10,442,917...10,473,689
Ensembl chr 4:10,442,917...10,473,694
JBrowse link
G Nudt4 nudix hydrolase 4 increases expression ISO Ketoconazole results in increased expression of NUDT4 mRNA CTD PMID:36621641 NCBI chr 7:30,188,100...30,204,615
Ensembl chr 7:30,188,100...30,204,615
JBrowse link
G Nup214 nucleoporin 214 decreases expression EXP Ketoconazole results in decreased expression of NUP214 mRNA CTD PMID:36653537 NCBI chr 3:15,255,111...15,340,568
Ensembl chr 3:15,255,119...15,340,568
JBrowse link
G Nup62 nucleoporin 62 decreases expression EXP Ketoconazole results in decreased expression of NUP62 mRNA CTD PMID:36653537 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Ketoconazole results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
JBrowse link
G Oaf out at first homolog affects expression EXP Ketoconazole affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
JBrowse link
G Ociad1 OCIA domain containing 1 increases expression ISO Ketoconazole results in increased expression of OCIAD1 mRNA CTD PMID:36621641 NCBI chr14:34,897,851...34,915,291
Ensembl chr14:34,897,847...34,915,286
JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Ketoconazole results in increased expression of ODC1 mRNA CTD PMID:37077353 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Osbpl8 oxysterol binding protein-like 8 increases expression ISO Ketoconazole results in increased expression of OSBPL8 mRNA CTD PMID:36621641 NCBI chr 7:46,596,944...46,749,888
Ensembl chr 7:46,596,983...46,749,888
JBrowse link
G Ovol1 ovo like transcriptional repressor 1 increases expression ISO Ketoconazole results in increased expression of OVOL1 mRNA; Ketoconazole results in increased expression of OVOL1 protein CTD PMID:26873447 NCBI chr 1:202,855,261...202,868,858
Ensembl chr 1:202,855,265...202,866,831
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide increases expression EXP Ketoconazole results in increased expression of OXT mRNA CTD PMID:37077353 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
JBrowse link
G Pacs1 phosphofurin acidic cluster sorting protein 1 decreases expression EXP Ketoconazole results in decreased expression of PACS1 mRNA CTD PMID:37077353 NCBI chr 1:202,437,503...202,569,473
Ensembl chr 1:202,437,505...202,569,473
JBrowse link
G Palld palladin, cytoskeletal associated protein decreases expression ISO Ketoconazole results in decreased expression of PALLD mRNA CTD PMID:31099283 NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337
JBrowse link
G Papolg poly(A) polymerase gamma increases expression ISO Ketoconazole results in increased expression of PAPOLG mRNA CTD PMID:36621641 NCBI chr14:97,827,712...97,861,024
Ensembl chr14:97,827,712...97,861,024
JBrowse link
G Parg poly (ADP-ribose) glycohydrolase increases expression ISO Ketoconazole results in increased expression of PARG mRNA CTD PMID:36621641 NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO Ketoconazole results in increased expression of PARP1 mRNA CTD PMID:36621641 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pc pyruvate carboxylase affects expression
increases expression
EXP Ketoconazole affects the expression of PC mRNA
Ketoconazole results in increased expression of PC mRNA
CTD PMID:18355885 PMID:37077353 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pcbd1 pterin-4 alpha-carbinolamine dehydratase 1 increases expression ISO Ketoconazole results in increased expression of PCBD1 mRNA CTD PMID:36621641 NCBI chr20:29,037,545...29,044,322
Ensembl chr20:28,953,864...29,044,292
Ensembl chr20:28,953,864...29,044,292
JBrowse link
G Pcdh9 protocadherin 9 increases expression ISO Ketoconazole results in increased expression of PCDH9 mRNA CTD PMID:36621641 NCBI chr15:69,340,108...70,237,531
Ensembl chr15:69,340,645...70,237,538
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP Ketoconazole results in increased expression of PCNA mRNA CTD PMID:37077353 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pcnp PEST proteolytic signal containing nuclear protein decreases expression ISO Ketoconazole results in decreased expression of PCNP mRNA CTD PMID:36621641 NCBI chr11:44,592,766...44,607,372
Ensembl chr11:44,592,742...44,607,348
JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 increases expression ISO Ketoconazole results in increased expression of PCSK5 mRNA CTD PMID:36621641 NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression EXP Ketoconazole results in increased expression of PCSK9 mRNA CTD PMID:28263823 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
JBrowse link
G Pctp phosphatidylcholine transfer protein increases expression EXP Ketoconazole results in increased expression of PCTP mRNA CTD PMID:37077353 NCBI chr10:74,808,887...74,856,260
Ensembl chr10:74,808,887...74,849,867
JBrowse link
G Pde3b phosphodiesterase 3B decreases expression EXP Ketoconazole results in decreased expression of PDE3B mRNA CTD PMID:37077353 NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334
JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta increases expression EXP Ketoconazole results in increased expression of PDHB mRNA CTD PMID:37077353 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500
JBrowse link
G Pdlim5 PDZ and LIM domain 5 increases expression ISO Ketoconazole results in increased expression of PDLIM5 mRNA CTD PMID:36621641 NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275
JBrowse link
G Pdyn prodynorphin decreases expression EXP Ketoconazole results in decreased expression of PDYN mRNA CTD PMID:37077353 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 increases expression EXP Ketoconazole results in increased expression of PEA15 mRNA CTD PMID:37077353 NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase affects expression EXP Ketoconazole affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 9:73,897,877...73,926,511
Ensembl chr 9:73,897,880...73,926,511
JBrowse link
G Pepd peptidase D increases expression EXP Ketoconazole results in increased expression of PEPD mRNA CTD PMID:37077353 NCBI chr 1:87,536,650...87,681,233
Ensembl chr 1:87,536,609...87,681,231
JBrowse link
G Per3 period circadian regulator 3 decreases expression EXP Ketoconazole results in decreased expression of PER3 mRNA CTD PMID:37077353 NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607
JBrowse link
G Perp p53 apoptosis effector related to PMP22 decreases expression ISO Ketoconazole results in decreased expression of PERP mRNA CTD PMID:36621641 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511
JBrowse link
G Pf4 platelet factor 4 increases expression EXP Ketoconazole results in increased expression of PF4 mRNA CTD PMID:37077353 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Pgf placental growth factor increases expression EXP Ketoconazole results in increased expression of PGF mRNA CTD PMID:37077353 NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
JBrowse link
G Pgr progesterone receptor increases expression ISO Ketoconazole results in increased expression of PGR mRNA CTD PMID:35307500 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Phf6 PHD finger protein 6 increases expression ISO Ketoconazole results in increased expression of PHF6 mRNA CTD PMID:36621641 NCBI chr  X:132,656,658...132,699,720
Ensembl chr  X:132,656,672...132,699,127
JBrowse link
G Phf7 PHD finger protein 7 increases expression ISO Ketoconazole results in increased expression of PHF7 mRNA CTD PMID:36621641 NCBI chr16:6,433,535...6,446,314
Ensembl chr16:6,433,537...6,446,911
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase decreases expression ISO Ketoconazole results in decreased expression of PIM1 mRNA CTD PMID:36621641 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174
JBrowse link
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha increases expression ISO Ketoconazole results in increased expression of PIP5K1A mRNA CTD PMID:36621641 NCBI chr 2:182,628,299...182,671,584
Ensembl chr 2:182,628,300...182,671,598
JBrowse link
G Pkp2 plakophilin 2 increases expression ISO Ketoconazole results in increased expression of PKP2 mRNA CTD PMID:36621641 NCBI chr11:84,661,783...84,727,730
Ensembl chr11:84,661,783...84,727,730
JBrowse link
G Pla2g3 phospholipase A2, group III increases expression EXP Ketoconazole results in increased expression of PLA2G3 mRNA CTD PMID:37077353 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913
JBrowse link
G Pla2g7 phospholipase A2 group VII decreases expression EXP Ketoconazole results in decreased expression of PLA2G7 mRNA CTD PMID:36653537 NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
JBrowse link
G Plaat3 phospholipase A and acyltransferase 3 increases expression ISO Ketoconazole results in increased expression of PLAAT3 mRNA CTD PMID:36621641 NCBI chr 1:204,782,608...204,816,397
Ensembl chr 1:204,782,729...204,817,667
JBrowse link
G Plag1 PLAG1 zinc finger decreases expression EXP Ketoconazole results in decreased expression of PLAG1 mRNA CTD PMID:36653537 NCBI chr 5:16,902,057...16,956,727
Ensembl chr 5:16,905,394...16,913,647
JBrowse link
G Plcxd2 phosphatidylinositol-specific phospholipase C, X domain containing 2 increases expression EXP Ketoconazole results in increased expression of PLCXD2 mRNA CTD PMID:36653537 NCBI chr11:54,800,977...54,853,348
Ensembl chr11:54,789,477...54,853,344
JBrowse link
G Plekha4 pleckstrin homology domain containing A4 increases expression EXP Ketoconazole results in increased expression of PLEKHA4 mRNA CTD PMID:28263823 NCBI chr 1:96,005,824...96,028,826
Ensembl chr 1:96,006,000...96,028,826
JBrowse link
G Plin4 perilipin 4 increases expression EXP Ketoconazole results in increased expression of PLIN4 mRNA CTD PMID:37077353 NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056
JBrowse link
G Plscr4 phospholipid scramblase 4 decreases expression ISO Ketoconazole results in decreased expression of PLSCR4 mRNA CTD PMID:36621641 NCBI chr 8:92,987,290...93,026,056
Ensembl chr 8:92,987,381...93,026,049
JBrowse link
G Pmm1 phosphomannomutase 1 increases expression EXP Ketoconazole results in increased expression of PMM1 mRNA CTD PMID:37077353 NCBI chr 7:113,466,632...113,477,004
Ensembl chr 7:113,466,632...113,477,022
JBrowse link
G Pmvk phosphomevalonate kinase increases expression EXP Ketoconazole results in increased expression of PMVK mRNA CTD PMID:28263823 PMID:37077353 NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases expression EXP Ketoconazole results in decreased expression of PNPLA6 mRNA CTD PMID:37077353 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734
JBrowse link
G Polr1d RNA polymerase I and III subunit D decreases expression ISO Ketoconazole results in decreased expression of POLR1D mRNA CTD PMID:36621641 NCBI chr12:7,970,592...8,004,157
Ensembl chr12:7,970,595...8,005,624
JBrowse link
G Pomc proopiomelanocortin decreases expression ISO Ketoconazole results in decreased expression of POMC protein modified form CTD PMID:25808816 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Pon2 paraoxonase 2 increases expression ISO Ketoconazole results in increased expression of PON2 mRNA CTD PMID:36621641 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
JBrowse link
G Por cytochrome p450 oxidoreductase affects expression
multiple interactions
increases expression
decreases expression
EXP
ISO
Ketoconazole affects the expression of POR mRNA
Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]
Ketoconazole results in increased expression of POR protein
Ketoconazole results in decreased expression of POR mRNA
CTD PMID:17966066 PMID:18355885 PMID:24120545 PMID:36653537 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Pou2f1 POU class 2 homeobox 1 decreases expression EXP Ketoconazole results in decreased expression of POU2F1 mRNA CTD PMID:37077353 NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Ketoconazole results in decreased expression of POU5F1 mRNA CTD PMID:16574651 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Ketoconazole inhibits the reaction [Clofibrate results in increased expression of PPARA mRNA] CTD PMID:14690017 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression EXP Ketoconazole results in increased expression of PPARD mRNA CTD PMID:37077353 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression EXP Ketoconazole results in decreased expression of PPARGC1A mRNA CTD PMID:37077353 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ppargc1b PPARG coactivator 1 beta decreases expression EXP Ketoconazole results in decreased expression of PPARGC1B mRNA CTD PMID:37077353 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta decreases expression EXP Ketoconazole results in decreased expression of PPP2CB mRNA CTD PMID:25787151 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta increases expression EXP Ketoconazole results in increased expression of PPP2R2B mRNA CTD PMID:37077353 NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025
JBrowse link
G Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha decreases expression ISO Ketoconazole results in decreased expression of PPP2R3A mRNA CTD PMID:36621641 NCBI chr 8:101,703,512...101,841,530
Ensembl chr 8:101,704,778...101,841,502
JBrowse link
G Pqbp1 polyglutamine binding protein 1 decreases expression ISO Ketoconazole results in decreased expression of PQBP1 mRNA CTD PMID:36621641 NCBI chr  X:14,603,516...14,608,091
Ensembl chr  X:14,603,539...14,608,087
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression EXP Ketoconazole results in decreased expression of PRC1 mRNA CTD PMID:37077353 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
JBrowse link
G Prcc proline rich mitotic checkpoint control factor increases expression ISO Ketoconazole results in increased expression of PRCC mRNA CTD PMID:36621641 NCBI chr 2:173,326,261...173,351,799
Ensembl chr 2:173,326,259...173,351,825
JBrowse link
G Prdm1 PR/SET domain 1 decreases expression EXP Ketoconazole results in decreased expression of PRDM1 mRNA CTD PMID:37077353 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
JBrowse link
G Prdx3 peroxiredoxin 3 decreases expression EXP Ketoconazole results in decreased expression of PRDX3 mRNA CTD PMID:25787151 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta decreases expression ISO Ketoconazole results in decreased expression of PRKAR1B mRNA CTD PMID:36621641 NCBI chr12:15,492,233...15,624,942
Ensembl chr12:15,511,801...15,624,942
JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 increases expression EXP Ketoconazole results in increased expression of PRKG2 mRNA CTD PMID:37077353 NCBI chr14:10,559,882...10,668,479
Ensembl chr14:10,559,882...10,666,888
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions
increases expression
increases response to substance
EXP 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ketoconazole results in increased expression of PRKN protein]; tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA]; tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN protein]
Ketoconazole results in increased expression of PRKN mRNA; Ketoconazole results in increased expression of PRKN protein
PRKN protein results in increased susceptibility to Ketoconazole
CTD PMID:25787151 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Prl prolactin decreases expression EXP Ketoconazole results in decreased expression of PRL mRNA CTD PMID:25808816 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Psmb8 proteasome 20S subunit beta 8 decreases expression ISO Ketoconazole results in decreased expression of PSMB8 mRNA CTD PMID:36621641 NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283
JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 decreases expression ISO Ketoconazole results in decreased expression of PSMC2 mRNA CTD PMID:36621641 NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185
JBrowse link
G Psmd13 proteasome 26S subunit, non-ATPase 13 decreases expression ISO Ketoconazole results in decreased expression of PSMD13 mRNA CTD PMID:36621641 NCBI chr 1:195,964,617...195,976,895
Ensembl chr 1:195,964,138...195,976,905
JBrowse link
G Psmd5 proteasome 26S subunit, non-ATPase 5 increases expression ISO Ketoconazole results in increased expression of PSMD5 mRNA CTD PMID:36621641 NCBI chr 3:18,133,715...18,151,000
Ensembl chr 3:18,133,717...18,151,029
JBrowse link
G Psmg3 proteasome assembly chaperone 3 increases expression ISO Ketoconazole results in increased expression of PSMG3 mRNA CTD PMID:36621641 NCBI chr12:14,809,440...14,812,357
Ensembl chr12:14,809,450...14,812,342
JBrowse link
G Psmg4 proteasome assembly chaperone 4 increases expression ISO Ketoconazole results in increased expression of PSMG4 mRNA CTD PMID:36621641 NCBI chr17:30,710,682...30,718,035
Ensembl chr17:30,710,682...30,718,082
JBrowse link
G Pten phosphatase and tensin homolog decreases expression EXP Ketoconazole results in decreased expression of PTEN mRNA CTD PMID:37077353 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgds prostaglandin D2 synthase decreases expression
increases expression
ISO
EXP
Ketoconazole results in decreased expression of PTGDS mRNA
Ketoconazole results in increased expression of PTGDS mRNA
CTD PMID:31099283 PMID:36653537 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions
increases response to substance
ISO PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
PTGER2 protein results in increased susceptibility to Ketoconazole
CTD PMID:16784723 NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions
increases response to substance
increases expression
ISO
EXP
PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
PTGER3 protein results in increased susceptibility to Ketoconazole
Ketoconazole results in increased expression of PTGER3 mRNA
CTD PMID:16784723 PMID:37077353 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]]; Bucladesine inhibits the reaction [Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [ATF1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone promotes the reaction [CREB1 protein modified form binds to PTGS2 promoter]]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 mRNA]; Ketoconazole inhibits the reaction [Dinoprostone results in increased expression of PTGS2 protein]
Ketoconazole results in increased expression of PTGS2 mRNA
CTD PMID:12164941 PMID:32816093 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pth parathyroid hormone multiple interactions EXP Ketoconazole inhibits the reaction [25-hydroxyvitamin D results in decreased expression of PTH mRNA] CTD PMID:18304585 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
JBrowse link
G Ptpn14 protein tyrosine phosphatase, non-receptor type 14 increases expression ISO Ketoconazole results in increased expression of PTPN14 mRNA CTD PMID:36621641 NCBI chr13:101,268,258...101,420,508
Ensembl chr13:101,268,416...101,414,088
JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F decreases expression EXP Ketoconazole results in decreased expression of PTPRF mRNA CTD PMID:37077353 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023
JBrowse link
G Ptx3 pentraxin 3 affects expression EXP Ketoconazole affects the expression of PTX3 mRNA CTD PMID:36653537 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
JBrowse link
G Pygl glycogen phosphorylase L increases expression EXP Ketoconazole results in increased expression of PYGL mRNA CTD PMID:37077353 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
JBrowse link
G Qsox1 quiescin sulfhydryl oxidase 1 decreases expression ISO Ketoconazole results in decreased expression of QSOX1 mRNA CTD PMID:36621641 NCBI chr13:67,949,780...67,987,434
Ensembl chr13:67,949,780...67,987,459
JBrowse link
G Rab3b RAB3B, member RAS oncogene family increases expression ISO Ketoconazole results in increased expression of RAB3B mRNA CTD PMID:36621641 NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401
JBrowse link
G Rab9a RAB9A, member RAS oncogene family increases expression ISO Ketoconazole results in increased expression of RAB9A mRNA CTD PMID:36621641 NCBI chr  X:27,955,552...28,009,870
Ensembl chr  X:27,952,204...28,001,622
JBrowse link
G Ralgdsl1 ral guanine nucleotide dissociation stimulator like 1 decreases expression EXP Ketoconazole results in decreased expression of RGL1 mRNA CTD PMID:37077353 NCBI chr13:64,634,489...64,904,170
Ensembl chr13:64,635,246...64,904,191
JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 decreases expression EXP Ketoconazole results in decreased expression of RAPGEF1 mRNA CTD PMID:37077353 NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO Ketoconazole results in decreased expression of RAPGEF4 mRNA CTD PMID:31099283 NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
JBrowse link
G Rarb retinoic acid receptor, beta increases expression
decreases expression
EXP Ketoconazole results in increased expression of RARB mRNA
Ketoconazole results in decreased expression of RARB mRNA
CTD PMID:28263823 PMID:37077353 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rarres2 retinoic acid receptor responder 2 increases expression EXP Ketoconazole results in increased expression of RARRES2 mRNA CTD PMID:37077353 NCBI chr 4:77,522,549...77,525,733
Ensembl chr 4:77,522,535...77,525,556
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression EXP Ketoconazole affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
JBrowse link
G Rbm26 RNA binding motif protein 26 decreases expression ISO Ketoconazole results in decreased expression of RBM26 mRNA CTD PMID:36621641 NCBI chr15:81,884,783...81,964,245
Ensembl chr15:81,887,219...81,964,118
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein] CTD PMID:31168027 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin decreases expression ISO Ketoconazole results in decreased expression of REN protein CTD PMID:2632720 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Rft1 RFT1 homolog decreases expression ISO Ketoconazole results in decreased expression of RFT1 mRNA CTD PMID:36621641 NCBI chr16:5,827,063...5,861,120
Ensembl chr16:5,827,088...5,861,120
JBrowse link
G Rgs16 regulator of G-protein signaling 16 decreases expression ISO Ketoconazole results in decreased expression of RGS16 mRNA CTD PMID:31099283 NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857
JBrowse link
G Rhno1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 increases expression ISO Ketoconazole results in increased expression of RHNO1 mRNA CTD PMID:36621641 NCBI chr 4:161,634,047...161,639,437
Ensembl chr 4:161,634,048...161,639,371
JBrowse link
G Rhob ras homolog family member B increases expression EXP Ketoconazole results in increased expression of RHOB mRNA CTD PMID:37077353 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Rilpl1 Rab interacting lysosomal protein-like 1 decreases expression ISO Ketoconazole results in decreased expression of RILPL1 mRNA CTD PMID:36621641 NCBI chr12:32,071,870...32,109,687
Ensembl chr12:32,071,693...32,109,938
JBrowse link
G Rnase4 ribonuclease A family member 4 decreases expression EXP Ketoconazole results in decreased expression of RNASE4 mRNA CTD PMID:36653537 NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117
JBrowse link
G Rnf115 ring finger protein 115 increases expression ISO Ketoconazole results in increased expression of RNF115 mRNA CTD PMID:36621641 NCBI chr 2:184,262,087...184,329,839
Ensembl chr 2:184,262,371...184,329,823
JBrowse link
G Rnf41 ring finger protein 41 increases expression EXP Ketoconazole results in increased expression of RNF41 mRNA CTD PMID:25787151 NCBI chr 7:838,160...876,869
Ensembl chr 7:838,203...865,511
JBrowse link
G Rnf8 ring finger protein 8 decreases expression ISO Ketoconazole results in decreased expression of RNF8 mRNA CTD PMID:36621641 NCBI chr20:7,682,258...7,710,448
Ensembl chr20:7,682,322...7,708,491
JBrowse link
G Rpp25 ribonuclease P and MRP subunit p25 increases expression ISO Ketoconazole results in increased expression of RPP25 mRNA CTD PMID:31099283 NCBI chr 8:57,907,352...57,908,732
Ensembl chr 8:57,907,352...57,908,732
JBrowse link
G Rps25 ribosomal protein s25 increases expression ISO Ketoconazole results in increased expression of RPS25 mRNA CTD PMID:36621641 NCBI chr 8:44,733,623...44,735,999
Ensembl chr 8:44,733,029...44,737,271
JBrowse link
G Rpsa ribosomal protein SA increases expression EXP Ketoconazole results in increased expression of RPSA mRNA CTD PMID:37077353 NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 increases expression ISO Ketoconazole results in increased expression of RRM2 mRNA CTD PMID:36621641 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Rsf1 remodeling and spacing factor 1 increases expression ISO Ketoconazole results in increased expression of RSF1 mRNA CTD PMID:36621641 NCBI chr 1:151,892,055...152,015,089
Ensembl chr 1:151,892,434...152,009,051
JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression EXP Ketoconazole results in decreased expression of RT1-BB mRNA CTD PMID:36653537 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression EXP Ketoconazole affects the expression of RT1-S3 mRNA CTD PMID:18355885 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions
decreases expression
ISO
EXP
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of RUNX2 mRNA]
Ketoconazole results in decreased expression of RUNX2 mRNA
CTD PMID:21542014 PMID:37077353 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Rxra retinoid X receptor alpha decreases expression EXP Ketoconazole results in decreased expression of RXRA mRNA CTD PMID:37077353 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Rxrg retinoid X receptor gamma decreases expression EXP Ketoconazole results in decreased expression of RXRG mRNA CTD PMID:37077353 NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167
JBrowse link
G Samd8 sterile alpha motif domain containing 8 increases expression ISO Ketoconazole results in increased expression of SAMD8 mRNA CTD PMID:36621641 NCBI chr15:2,512,104...2,562,368
Ensembl chr15:2,512,105...2,515,379
Ensembl chr15:2,512,105...2,515,379
JBrowse link
G Sbno1 strawberry notch homolog 1 increases expression EXP Ketoconazole results in increased expression of SBNO1 mRNA CTD PMID:36653537 NCBI chr12:32,175,176...32,234,200
Ensembl chr12:32,185,485...32,230,158
JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP Ketoconazole results in increased expression of SC5D mRNA CTD PMID:28263823 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
increases expression
EXP
ISO
Ketoconazole results in decreased expression of SCARB1 mRNA
Ketoconazole results in increased expression of SCARB1 mRNA
CTD PMID:36621641 PMID:37077353 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Scarb2 scavenger receptor class B, member 2 decreases expression ISO Ketoconazole results in decreased expression of SCARB2 mRNA CTD PMID:36621641 NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813
JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP
ISO
Ketoconazole results in increased expression of SCD mRNA; Ketoconazole results in increased expression of SCD1 mRNA
Ketoconazole results in increased expression of SCD mRNA; Ketoconazole results in increased expression of SCD protein
CTD PMID:28263823 PMID:36621641 PMID:37077353 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Scgb1c1 secretoglobin, family 1C, member 1 increases expression EXP Ketoconazole results in increased expression of SCGB1C1 mRNA CTD PMID:36653537 NCBI chr 1:195,922,660...195,925,022
Ensembl chr 1:195,923,803...195,925,022
JBrowse link
G Scp2 sterol carrier protein 2 increases expression EXP Ketoconazole results in increased expression of SCP2 mRNA CTD PMID:37077353 NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287
JBrowse link
G Sdc1 syndecan 1 increases expression EXP
ISO
Ketoconazole results in increased expression of SDC1 mRNA CTD PMID:36621641 PMID:37077353 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264
JBrowse link
G Sdc4 syndecan 4 increases expression EXP Ketoconazole results in increased expression of SDC4 mRNA CTD PMID:36653537 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
JBrowse link
G Secisbp2 SECIS binding protein 2 decreases expression ISO Ketoconazole results in decreased expression of SECISBP2 mRNA CTD PMID:36621641 NCBI chr17:13,538,513...13,569,573
Ensembl chr17:13,538,513...13,569,523
JBrowse link
G Sema3a semaphorin 3A decreases expression EXP Ketoconazole results in decreased expression of SEMA3A mRNA CTD PMID:37077353 NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432
JBrowse link
G Sema3b semaphorin 3B multiple interactions ISO Ketoconazole promotes the reaction [Calcitriol results in increased expression of SEMA3B mRNA] CTD PMID:12040012 NCBI chr 8:108,271,663...108,280,326
Ensembl chr 8:108,271,666...108,282,919
JBrowse link
G Sema3d semaphorin 3D affects expression ISO Ketoconazole affects the expression of SEMA3D mRNA CTD PMID:36621641 NCBI chr 4:22,316,769...22,505,930
Ensembl chr 4:22,316,779...22,505,930
JBrowse link
G Sema3e semaphorin 3E increases expression ISO Ketoconazole results in increased expression of SEMA3E mRNA CTD PMID:31099283 NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229
JBrowse link
G Sema7a semaphorin 7A (John Milton Hagen blood group) increases expression EXP Ketoconazole results in increased expression of SEMA7A mRNA CTD PMID:37077353 NCBI chr 8:58,348,448...58,370,536
Ensembl chr 8:58,348,448...58,370,536
JBrowse link
G Serpina1 serpin family A member 1 increases expression EXP Ketoconazole results in increased expression of SERPINA1 mRNA CTD PMID:36653537 PMID:37077353 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression ISO Ketoconazole results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
JBrowse link
G Serpinb1a serpin family B member 1A multiple interactions ISO Ketoconazole promotes the reaction [Calcitriol results in increased expression of SERPINB1 mRNA] CTD PMID:26485663 NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102
JBrowse link
G Serpinb3 serpin family B member 3 multiple interactions ISO Ketoconazole promotes the reaction [Calcitriol results in decreased expression of SERPINB3 mRNA] CTD PMID:12040012 NCBI chr13:23,274,120...23,280,660
Ensembl chr13:23,274,484...23,313,682
JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions ISO Ketoconazole inhibits the reaction [Tunicamycin results in decreased glycosylation of SERPINH1 protein] CTD PMID:16330322 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801
JBrowse link
G Sestd1 SEC14 and spectrin domain containing 1 increases expression ISO Ketoconazole results in increased expression of SESTD1 mRNA CTD PMID:36621641 NCBI chr 3:62,123,590...62,220,759
Ensembl chr 3:62,129,887...62,220,546
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression EXP Ketoconazole results in increased expression of SGK1 mRNA CTD PMID:36653537 PMID:37077353 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Sh3d19 SH3 domain containing 19 increases expression ISO Ketoconazole results in increased expression of SH3D19 mRNA CTD PMID:36621641 NCBI chr 2:171,356,244...171,516,042
Ensembl chr 2:171,356,251...171,515,561
JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 affects expression EXP Ketoconazole affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr 1:136,124,500...136,255,669
Ensembl chr 1:136,124,499...136,255,584
JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 decreases expression ISO Ketoconazole results in decreased expression of SH3RF1 mRNA CTD PMID:36621641 NCBI chr16:28,735,522...28,901,261
Ensembl chr16:28,735,440...28,901,644
JBrowse link
G Shq1 SHQ1, H/ACA ribonucleoprotein assembly factor increases expression EXP Ketoconazole results in increased expression of SHQ1 mRNA CTD PMID:36653537 NCBI chr 4:133,213,357...133,305,586
Ensembl chr 4:133,213,361...133,305,586
JBrowse link
G Shroom2 shroom family member 2 increases expression EXP Ketoconazole results in increased expression of SHROOM2 mRNA CTD PMID:36653537 NCBI chr  X:21,812,469...21,983,724
Ensembl chr  X:21,812,469...21,984,153
JBrowse link
G Sirt1 sirtuin 1 decreases expression EXP Ketoconazole results in decreased expression of SIRT1 mRNA CTD PMID:37077353 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sirt2 sirtuin 2 decreases expression EXP Ketoconazole results in decreased expression of SIRT2 mRNA CTD PMID:37077353 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 increases expression ISO Ketoconazole results in increased expression of SKAP2 mRNA CTD PMID:36621641 NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions EXP [Chenodeoxycholic Acid co-treated with Ketoconazole] results in decreased expression of SLC10A1 mRNA CTD PMID:30985903 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc17a7 solute carrier family 17 member 7 increases expression EXP Ketoconazole results in increased expression of SLC17A7 mRNA CTD PMID:37077353 NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO Ketoconazole inhibits the reaction [Maneb results in decreased expression of SLC18A2 protein]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of SLC18A2 protein] CTD PMID:22334051 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Slc25a1 solute carrier family 25 member 1 increases expression EXP Ketoconazole results in increased expression of SLC25A1 mRNA CTD PMID:37077353 NCBI chr11:83,055,764...83,058,781
Ensembl chr11:83,055,748...83,058,781
JBrowse link
G Slc25a20 solute carrier family 25 member 20 increases expression EXP Ketoconazole results in increased expression of SLC25A20 mRNA CTD PMID:37077353 NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
JBrowse link
G Slc25a36 solute carrier family 25 member 36 increases expression ISO Ketoconazole results in increased expression of SLC25A36 mRNA CTD PMID:31099283 NCBI chr 8:97,659,848...97,693,735
Ensembl chr 8:97,662,127...97,693,703
JBrowse link
G Slc25a53 solute carrier family 25, member 53 decreases expression ISO Ketoconazole results in decreased expression of SLC25A53 mRNA CTD PMID:36621641 NCBI chr  X:100,306,917...100,319,662
Ensembl chr  X:100,306,915...100,319,863
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression EXP Ketoconazole results in increased expression of SLC2A1 mRNA CTD PMID:37077353 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Ketoconazole results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slc38a3 solute carrier family 38, member 3 decreases expression EXP Ketoconazole results in decreased expression of SLC38A3 mRNA CTD PMID:37077353 NCBI chr 8:108,323,889...108,339,959
Ensembl chr 8:108,323,894...108,339,988
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Ketoconazole inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Ketoconazole inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Slc6a6 solute carrier family 6 member 6 affects expression EXP Ketoconazole affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Ketoconazole results in increased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression EXP Ketoconazole affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slit2 slit guidance ligand 2 increases expression ISO Ketoconazole results in increased expression of SLIT2 mRNA CTD PMID:36621641 NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression
increases expression
ISO
EXP
Ketoconazole results in decreased expression of SLPI mRNA
Ketoconazole results in increased expression of SLPI mRNA
CTD PMID:32816093 PMID:36653537 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 decreases expression ISO Ketoconazole results in decreased expression of SMARCC1 mRNA CTD PMID:36621641 NCBI chr 8:110,111,097...110,214,734
Ensembl chr 8:110,111,122...110,214,720
JBrowse link
G Smim15 small integral membrane protein 15 increases expression ISO Ketoconazole results in increased expression of SMIM15 mRNA CTD PMID:36621641 NCBI chr 2:39,528,256...39,533,416
Ensembl chr 2:39,527,425...39,534,237
JBrowse link
G Smim19 small integral membrane protein 19 decreases expression ISO Ketoconazole results in decreased expression of SMIM19 mRNA CTD PMID:36621641 NCBI chr16:69,551,507...69,564,323
Ensembl chr16:69,553,916...69,567,245
JBrowse link
G Smug1 single-strand-selective monofunctional uracil-DNA glycosylase 1 decreases expression ISO Ketoconazole results in decreased expression of SMUG1 mRNA CTD PMID:36621641 NCBI chr 7:134,288,565...134,302,179
Ensembl chr 7:134,287,675...134,297,226
JBrowse link
G Sncg synuclein, gamma increases expression EXP Ketoconazole results in increased expression of SNCG mRNA CTD PMID:37077353 NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368
JBrowse link
G Snx1 sorting nexin 1 increases expression EXP Ketoconazole results in increased expression of SNX1 mRNA CTD PMID:37077353 NCBI chr 8:66,630,086...66,670,418
Ensembl chr 8:66,630,086...66,670,360
JBrowse link
G Snx18 sorting nexin 18 increases expression ISO Ketoconazole results in increased expression of SNX18 mRNA CTD PMID:36621641 NCBI chr 2:45,232,325...45,258,345
Ensembl chr 2:45,232,325...45,258,345
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Ketoconazole results in increased expression of SOD1 mRNA CTD PMID:37077353 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression EXP Ketoconazole results in increased expression of SOX9 mRNA CTD PMID:36653537 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Sp1 Sp1 transcription factor decreases expression EXP Ketoconazole results in decreased expression of SP1 mRNA CTD PMID:37077353 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sphk1 sphingosine kinase 1 increases expression EXP Ketoconazole results in increased expression of SPHK1 mRNA CTD PMID:25787151 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Spon2 spondin 2 decreases expression EXP Ketoconazole results in decreased expression of SPON2 mRNA CTD PMID:36653537 NCBI chr14:77,505,695...77,518,001
Ensembl chr14:77,511,901...77,517,996
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Ketoconazole results in increased expression of SPP1 mRNA CTD PMID:37077353 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases expression ISO Ketoconazole results in increased expression of SPTAN1 mRNA CTD PMID:36621641 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
JBrowse link
G Sptssa serine palmitoyltransferase, small subunit A decreases expression ISO Ketoconazole results in decreased expression of SPTSSA mRNA CTD PMID:36621641 NCBI chr 6:72,144,714...72,156,130
Ensembl chr 6:72,144,714...72,156,214
JBrowse link
G Sqle squalene epoxidase increases expression EXP Ketoconazole results in increased expression of SQLE mRNA CTD PMID:28263823 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression EXP Ketoconazole results in increased expression of SREBF2 mRNA CTD PMID:28263823 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
G Srp54a signal recognition particle 54A increases expression ISO Ketoconazole results in increased expression of SRP54 mRNA CTD PMID:36621641 NCBI chr 6:72,587,584...72,626,878
Ensembl chr 6:72,587,605...72,625,189
JBrowse link
G Srxn1 sulfiredoxin 1 decreases expression EXP Ketoconazole results in decreased expression of SRXN1 mRNA CTD PMID:36653537 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G St13 ST13, Hsp70 interacting protein affects expression EXP Ketoconazole affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr 7:112,891,007...112,925,727
Ensembl chr 7:112,844,375...112,925,945
JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO Ketoconazole results in increased expression of STAR mRNA CTD PMID:10960482 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 increases expression EXP Ketoconazole results in increased expression of STARD4 mRNA CTD PMID:28263823 NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024
JBrowse link
G Stard5 StAR-related lipid transfer domain containing 5 decreases expression EXP Ketoconazole results in decreased expression of STARD5 mRNA CTD PMID:36653537 NCBI chr 1:137,606,151...137,616,017
Ensembl chr 1:137,606,177...137,616,469
JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression
multiple interactions
EXP
ISO
Ketoconazole results in increased expression of STAT1 mRNA
Ketoconazole inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]
CTD PMID:24471457 PMID:25787151 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression EXP Ketoconazole results in decreased expression of STAT3 mRNA CTD PMID:37077353 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases expression EXP Ketoconazole results in decreased expression of STAT5B mRNA CTD PMID:37077353 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Stbd1 starch binding domain 1 affects expression EXP Ketoconazole affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr14:15,470,452...15,473,857
Ensembl chr14:15,469,582...15,477,443
JBrowse link
G Stc1 stanniocalcin 1 affects expression EXP Ketoconazole affects the expression of STC1 mRNA CTD PMID:36653537 NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
JBrowse link
G Stc2 stanniocalcin 2 decreases expression ISO Ketoconazole results in decreased expression of STC2 mRNA CTD PMID:36621641 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Steap3 STEAP3 metalloreductase decreases expression ISO Ketoconazole results in decreased expression of STEAP3 mRNA CTD PMID:36621641 NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519
JBrowse link
G Stim1 stromal interaction molecule 1 decreases expression EXP Ketoconazole results in decreased expression of STIM1 mRNA CTD PMID:37077353 NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363
JBrowse link
G Stmn1 stathmin 1 affects expression EXP Ketoconazole affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Stmn2 stathmin 2 decreases expression EXP Ketoconazole results in decreased expression of STMN2 mRNA CTD PMID:36653537 NCBI chr 2:93,204,690...93,252,011
Ensembl chr 2:93,204,692...93,252,011
JBrowse link
G Stra8 stimulated by retinoic acid 8 increases expression ISO Ketoconazole results in increased expression of STRA8 mRNA CTD PMID:16461896 NCBI chr 4:63,601,443...63,624,777
Ensembl chr 4:63,601,604...63,624,771
JBrowse link
G Stx2 syntaxin 2 decreases expression ISO Ketoconazole results in decreased expression of STX2 mRNA CTD PMID:36621641 NCBI chr12:27,678,744...27,714,751
Ensembl chr12:27,689,819...27,714,751
JBrowse link
G Stxbp5 syntaxin binding protein 5 decreases expression EXP Ketoconazole results in decreased expression of STXBP5 mRNA CTD PMID:37077353 NCBI chr 1:4,182,489...4,335,290
Ensembl chr 1:4,185,529...4,335,101
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 increases expression ISO Ketoconazole results in increased expression of SULT1E1 mRNA CTD PMID:31099283 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Swi5 SWI5 homologous recombination repair protein increases expression ISO Ketoconazole results in increased expression of SWI5 mRNA CTD PMID:36621641 NCBI chr 3:15,574,687...15,583,760
Ensembl chr 3:15,564,715...15,583,805
JBrowse link
G Sycp3 synaptonemal complex protein 3 increases expression ISO Ketoconazole results in increased expression of SYCP3 mRNA CTD PMID:16574651 PMID:31099283 NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511
JBrowse link
G Syt3 synaptotagmin 3 decreases expression ISO Ketoconazole results in decreased expression of SYT3 mRNA CTD PMID:31099283 NCBI chr 1:94,880,835...94,895,518
Ensembl chr 1:94,881,247...94,895,246
JBrowse link
G Taf5l1 TATA-box binding protein associated factor 5 like 1 affects expression ISO Ketoconazole affects the expression of TAF5L mRNA CTD PMID:36621641 NCBI chr19:51,991,704...52,011,001
Ensembl chr19:51,991,708...52,011,295
JBrowse link
G Taf8 TATA-box binding protein associated factor 8 increases expression ISO Ketoconazole results in increased expression of TAF8 mRNA CTD PMID:36621641 NCBI chr 9:13,491,892...13,511,713
Ensembl chr 9:13,491,937...13,511,717
JBrowse link
G Tagln transgelin decreases expression
increases expression
ISO
EXP
Ketoconazole results in decreased expression of TAGLN mRNA
Ketoconazole results in increased expression of TAGLN mRNA
CTD PMID:17175557 PMID:37077353 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Tat tyrosine aminotransferase decreases expression ISO Ketoconazole results in decreased expression of TAT mRNA CTD PMID:16608920 PMID:25000292 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
JBrowse link
G Tbc1d9 TBC1 domain family member 9 increases expression ISO Ketoconazole results in increased expression of TBC1D9 mRNA CTD PMID:31099283 NCBI chr19:24,842,166...24,951,383
Ensembl chr19:24,842,205...24,943,129
JBrowse link
G Tbcc tubulin folding cofactor C increases expression
decreases expression
EXP
ISO
Ketoconazole results in increased expression of TBCC mRNA
Ketoconazole results in decreased expression of TBCC mRNA
CTD PMID:36621641 PMID:37077353 NCBI chr 9:14,098,855...14,100,043
Ensembl chr 9:14,098,868...14,100,042
JBrowse link
G Tbrg1 transforming growth factor beta regulator 1 increases expression ISO Ketoconazole results in increased expression of TBRG1 mRNA CTD PMID:36621641 NCBI chr 8:37,355,274...37,362,933
Ensembl chr 8:37,354,658...37,362,930
JBrowse link
G Tbxas1 thromboxane A synthase 1 increases expression EXP Ketoconazole results in increased expression of TBXAS1 mRNA CTD PMID:37077353 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
JBrowse link
G Tcf4 transcription factor 4 decreases expression EXP Ketoconazole results in decreased expression of TCF4 mRNA CTD PMID:37077353 NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425
JBrowse link
G Tedc2 tubulin epsilon and delta complex 2 increases expression EXP Ketoconazole results in increased expression of TEDC2 mRNA CTD PMID:36653537 NCBI chr10:13,246,032...13,251,196
Ensembl chr10:13,246,037...13,251,124
JBrowse link
G Tent4b terminal nucleotidyltransferase 4B increases expression EXP Ketoconazole results in increased expression of TENT4B mRNA CTD PMID:36653537 NCBI chr19:18,807,616...18,868,969
Ensembl chr19:18,807,525...18,869,537
JBrowse link
G Tex261 testis expressed 261 affects expression EXP Ketoconazole affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 4:116,253,547...116,260,730
Ensembl chr 4:116,244,600...116,260,253
JBrowse link
G Tfdp2 transcription factor Dp-2 decreases expression ISO Ketoconazole results in decreased expression of TFDP2 mRNA CTD PMID:36621641 NCBI chr 8:96,760,459...96,901,466
Ensembl chr 8:96,760,504...96,896,682
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO Ketoconazole results in increased expression of TFF1 mRNA CTD PMID:35307500 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP Ketoconazole results in decreased expression of TGFB3 mRNA CTD PMID:36653537 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression EXP Ketoconazole results in decreased expression of TGFBR1 mRNA CTD PMID:37077353 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression EXP Ketoconazole results in decreased expression of TGFBR2 mRNA CTD PMID:37077353 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Ketoconazole inhibits the reaction [Maneb results in decreased expression of TH protein]; Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]]; Ketoconazole inhibits the reaction [Paraquat results in decreased expression of TH protein] CTD PMID:19594327 PMID:22334051 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Timm10b translocase of inner mitochondrial membrane 10B affects expression EXP Ketoconazole affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr 1:159,980,525...159,983,371
Ensembl chr 1:159,980,484...159,981,642
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression EXP Ketoconazole results in decreased expression of TIMP1 mRNA CTD PMID:18289764 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 increases expression EXP Ketoconazole results in increased expression of TIMP4 mRNA CTD PMID:37077353 NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558
JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP Ketoconazole results in decreased expression of TJP1 mRNA CTD PMID:37077353 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tkt transketolase increases expression EXP Ketoconazole results in increased expression of TKT mRNA CTD PMID:37077353 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
G Tm7sf3 transmembrane 7 superfamily member 3 decreases expression ISO Ketoconazole results in decreased expression of TM7SF3 mRNA CTD PMID:36621641 NCBI chr 4:179,518,127...179,550,154
Ensembl chr 4:179,518,130...179,550,154
JBrowse link
G Tmem106b transmembrane protein 106B decreases expression ISO Ketoconazole results in decreased expression of TMEM106B mRNA CTD PMID:36621641 NCBI chr 4:41,328,125...41,347,315
Ensembl chr 4:41,327,994...41,345,619
JBrowse link
G Tmem18 transmembrane protein 18 decreases expression ISO Ketoconazole results in decreased expression of TMEM18 mRNA CTD PMID:36621641 NCBI chr 6:47,206,845...47,214,294
Ensembl chr 6:47,206,845...47,214,294
JBrowse link
G Tmem185b transmembrane protein 185B increases expression EXP Ketoconazole results in increased expression of TMEM185B mRNA CTD PMID:36653537 NCBI chr13:30,647,533...30,650,864
Ensembl chr13:30,647,482...30,650,858
JBrowse link
G Tmem47 transmembrane protein 47 increases expression ISO Ketoconazole results in increased expression of TMEM47 mRNA CTD PMID:36621641 NCBI chr  X:45,421,405...45,447,900
Ensembl chr  X:45,421,405...45,447,900
JBrowse link
G Tmem54 transmembrane protein 54 affects expression ISO Ketoconazole affects the expression of TMEM54 mRNA CTD PMID:36621641 NCBI chr 5:141,449,191...141,455,683
Ensembl chr 5:141,449,191...141,455,682
JBrowse link
G Tmsb10 thymosin, beta 10 decreases expression EXP Ketoconazole results in decreased expression of TMSB10 mRNA CTD PMID:18289764 NCBI chr 4:105,009,959...105,011,095
Ensembl chr 4:105,009,212...105,011,028
JBrowse link
G Tmsb4x thymosin beta 4, X-linked decreases expression ISO Ketoconazole results in decreased expression of TMSB4X mRNA CTD PMID:31099283 NCBI chr  X:27,144,666...27,146,667
Ensembl chr  X:27,128,610...27,146,667
JBrowse link
G Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 increases expression ISO Ketoconazole results in increased expression of TMTC3 mRNA CTD PMID:36621641 NCBI chr 7:35,264,886...35,310,010
Ensembl chr 7:35,264,892...35,310,385
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO
EXP
Ketoconazole results in increased expression of TNF mRNA
AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; AHR protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Ketoconazole inhibits the reaction [[Amiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [[desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of TNF mRNA]; Ketoconazole inhibits the reaction [Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Ketoconazole inhibits the reaction [Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNF protein]]; Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Ketoconazole inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; Ketoconazole promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
Ketoconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]
Ketoconazole inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
CTD PMID:11135059 PMID:12388057 PMID:15703382 PMID:16784723 PMID:21753779 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO Ketoconazole results in increased expression of TNFRSF1A mRNA CTD PMID:25808816 PMID:36621641 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO
EXP
Ketoconazole results in increased expression of TNFRSF1B mRNA CTD PMID:25808816 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 decreases expression EXP Ketoconazole results in decreased expression of TNFRSF9 mRNA CTD PMID:36653537 NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO Ketoconazole inhibits the reaction [CYP26A1 protein inhibits the reaction [Tretinoin results in increased activity of TNFSF10 protein]] CTD PMID:15703382 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnpo3 transportin 3 decreases expression EXP Ketoconazole results in decreased expression of TNPO3 mRNA CTD PMID:36653537 NCBI chr 4:58,142,954...58,220,365
Ensembl chr 4:58,143,001...58,220,433
JBrowse link
G Tp63 tumor protein p63 decreases expression ISO Ketoconazole results in decreased expression of TRP63 mRNA CTD PMID:25808816 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
JBrowse link
G Tp73 tumor protein p73 decreases expression EXP Ketoconazole results in decreased expression of TP73 mRNA CTD PMID:25808816 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
JBrowse link
G Tpcn1 two pore segment channel 1 increases expression ISO Ketoconazole results in increased expression of TPCN1 mRNA CTD PMID:31099283 NCBI chr12:35,972,813...36,029,632
Ensembl chr12:35,972,846...36,029,626
JBrowse link
G Tpm2 tropomyosin 2 increases expression EXP Ketoconazole results in increased expression of TPM2 mRNA CTD PMID:37077353 NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992
JBrowse link
G Tpmt thiopurine S-methyltransferase decreases expression ISO Ketoconazole results in decreased expression of TPMT mRNA CTD PMID:36621641 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709
JBrowse link
G Tpsb2 tryptase beta 2 increases expression EXP Ketoconazole results in increased expression of TPSB2 mRNA CTD PMID:36653537 NCBI chr10:14,381,779...14,383,571
Ensembl chr10:14,382,013...14,383,569
JBrowse link
G Tra2b transformer 2 beta decreases expression ISO Ketoconazole results in decreased expression of TRA2B mRNA CTD PMID:36621641 NCBI chr11:78,788,880...78,807,252
Ensembl chr11:78,788,884...78,807,249
JBrowse link
G Traf6 TNF receptor associated factor 6 decreases expression EXP Ketoconazole results in decreased expression of TRAF6 mRNA CTD PMID:37077353 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Trak2 trafficking kinesin protein 2 increases expression EXP Ketoconazole results in increased expression of TRAK2 mRNA CTD PMID:37077353 NCBI chr 9:60,348,531...60,414,036
Ensembl chr 9:60,350,012...60,413,996
JBrowse link
G Trappc4 trafficking protein particle complex subunit 4 decreases expression ISO Ketoconazole results in decreased expression of TRAPPC4 mRNA CTD PMID:36621641 NCBI chr 8:44,729,458...44,733,285
Ensembl chr 8:44,725,331...44,733,491
JBrowse link
G Trerf1 transcriptional regulating factor 1 decreases expression EXP Ketoconazole results in decreased expression of TRERF1 mRNA CTD PMID:37077353 NCBI chr 9:13,631,619...13,858,326
Ensembl chr 9:13,634,126...13,857,029
JBrowse link
G Trim23 tripartite motif-containing 23 affects expression ISO Ketoconazole affects the expression of TRIM23 mRNA CTD PMID:36621641 NCBI chr 2:35,302,405...35,335,746
Ensembl chr 2:35,302,409...35,335,743
JBrowse link
G Tshr thyroid stimulating hormone receptor decreases expression EXP Ketoconazole results in decreased expression of TSHR mRNA CTD PMID:37077353 NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
JBrowse link
G Tspan15 tetraspanin 15 decreases expression ISO Ketoconazole results in decreased expression of TSPAN15 mRNA CTD PMID:36621641 NCBI chr20:30,130,528...30,174,912
Ensembl chr20:30,130,530...30,174,930
JBrowse link
G Tspan8 tetraspanin 8 decreases expression ISO Ketoconazole results in decreased expression of TSPAN8 mRNA CTD PMID:31099283 NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356
JBrowse link
G Ttc39a tetratricopeptide repeat domain 39A increases expression ISO Ketoconazole results in increased expression of TTC39A mRNA CTD PMID:31099283 NCBI chr 5:124,165,102...124,204,740
Ensembl chr 5:124,151,760...124,204,973
JBrowse link
G Ttf2 transcription termination factor 2 affects expression ISO Ketoconazole affects the expression of TTF2 mRNA CTD PMID:36621641 NCBI chr 2:188,366,321...188,397,750
Ensembl chr 2:188,366,331...188,397,689
JBrowse link
G Tut7 terminal uridylyl transferase 7 increases expression ISO Ketoconazole results in increased expression of TUT7 mRNA CTD PMID:36621641 NCBI chr17:4,849,287...4,903,542
Ensembl chr17:4,849,283...4,903,169
JBrowse link
G Txlng taxilin gamma increases expression ISO Ketoconazole results in increased expression of TXLNG mRNA CTD PMID:36621641 NCBI chr  X:31,864,111...31,912,931
Ensembl chr  X:31,864,111...31,912,926
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression EXP Ketoconazole affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807
JBrowse link
G Ube2d2b ubiquitin-conjugating enzyme E2D 2B increases expression ISO Ketoconazole results in increased expression of UBE2D4 mRNA CTD PMID:36621641 NCBI chr14:1,915,999...1,917,473
Ensembl chr14:1,916,845...1,917,416
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression
multiple interactions
decreases activity
decreases expression
EXP
ISO
Ketoconazole affects the expression of UGT1A1 mRNA
[Ketoconazole results in decreased activity of UGT1A1 protein] which results in decreased metabolism of irinotecan
Ketoconazole results in decreased expression of UGT1A1 mRNA
CTD PMID:16608920 PMID:18355885 PMID:22447115 PMID:36893891 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 affects expression EXP Ketoconazole affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 affects expression EXP Ketoconazole affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Usp40 ubiquitin specific peptidase 40 decreases expression ISO Ketoconazole results in decreased expression of USP40 mRNA CTD PMID:36621641 NCBI chr 9:88,607,920...88,678,940
Ensembl chr 9:88,607,930...88,678,914
JBrowse link
G Vamp5 vesicle-associated membrane protein 5 increases expression EXP Ketoconazole results in increased expression of VAMP5 mRNA CTD PMID:37077353 NCBI chr 4:104,423,813...104,435,059
Ensembl chr 4:104,423,820...104,426,212
JBrowse link
G Vamp8 vesicle-associated membrane protein 8 increases expression EXP Ketoconazole results in increased expression of VAMP8 mRNA CTD PMID:37077353 NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897
JBrowse link
G Vcpkmt valosin containing protein lysine methyltransferase increases expression ISO Ketoconazole results in increased expression of VCPKMT mRNA CTD PMID:36621641 NCBI chr 6:88,036,485...88,042,151
Ensembl chr 6:88,036,494...88,042,000
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]; Ketoconazole inhibits the reaction [Vitamin D analog results in increased activity of VDR protein] CTD PMID:16280049 PMID:24792400 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO
EXP
Ketoconazole inhibits the reaction [CYP3A4 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]]; Ketoconazole inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]
Ketoconazole results in decreased expression of VEGFA mRNA
CTD PMID:21566342 PMID:37077353 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vegfb vascular endothelial growth factor B increases expression EXP Ketoconazole results in increased expression of VEGFB mRNA CTD PMID:36653537 NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944
JBrowse link
G Vgll3 vestigial-like family member 3 decreases expression ISO Ketoconazole results in decreased expression of VGLL3 mRNA CTD PMID:36621641 NCBI chr11:3,642,993...3,692,590
Ensembl chr11:3,643,069...3,689,140
JBrowse link
G Vgll4 vestigial-like family member 4 decreases expression ISO Ketoconazole results in decreased expression of VGLL4 mRNA CTD PMID:36621641 NCBI chr 4:147,925,630...148,038,519
Ensembl chr 4:147,927,034...148,038,471
JBrowse link
G Vim vimentin affects expression EXP Ketoconazole affects the expression of VIM mRNA CTD PMID:18289764 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Vldlr very low density lipoprotein receptor decreases expression EXP Ketoconazole results in decreased expression of VLDLR mRNA CTD PMID:37077353 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
JBrowse link
G Vof16 ischemia related factor vof-16 increases expression EXP Ketoconazole results in increased expression of VOF16 mRNA CTD PMID:36653537 NCBI chr 8:41,953,062...41,955,169 JBrowse link
G Wasf3 WASP family member 3 increases expression ISO Ketoconazole results in increased expression of WASF3 mRNA CTD PMID:36621641 NCBI chr12:8,563,805...8,660,799
Ensembl chr12:8,562,062...8,660,751
JBrowse link
G Wdr17 WD repeat domain 17 increases expression ISO Ketoconazole results in increased expression of WDR17 mRNA CTD PMID:31099283 NCBI chr16:37,059,923...37,191,125
Ensembl chr16:37,059,895...37,191,122
JBrowse link
G Wdr26 WD repeat domain 26 increases expression ISO Ketoconazole results in increased expression of WDR26 mRNA CTD PMID:36621641 NCBI chr13:92,930,282...92,972,061
Ensembl chr13:92,930,285...92,977,295
JBrowse link
G Wdr43 WD repeat domain 43 increases expression ISO Ketoconazole results in increased expression of WDR43 mRNA CTD PMID:36621641 NCBI chr 6:23,845,499...23,884,846
Ensembl chr 6:23,845,499...23,884,846
JBrowse link
G Wipf1 WAS/WASL interacting protein family, member 1 decreases expression EXP Ketoconazole results in decreased expression of WIPF1 mRNA CTD PMID:37077353 NCBI chr 3:58,314,521...58,416,668
Ensembl chr 3:58,314,542...58,372,742
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Ketoconazole results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 increases expression ISO Ketoconazole results in increased expression of WWTR1 mRNA CTD PMID:36621641 NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968
JBrowse link
G Xpot exportin for tRNA decreases expression ISO Ketoconazole results in decreased expression of XPOT mRNA CTD PMID:36621641 NCBI chr 7:57,111,536...57,152,013
Ensembl chr 7:57,111,536...57,152,099
JBrowse link
G Xylt1 xylosyltransferase 1 decreases expression EXP Ketoconazole results in decreased expression of XYLT1 mRNA CTD PMID:37077353 NCBI chr 1:171,643,925...171,929,774
Ensembl chr 1:171,643,925...171,926,783
JBrowse link
G Yeats4 YEATS domain containing 4 increases expression ISO Ketoconazole results in increased expression of YEATS4 mRNA CTD PMID:36621641 NCBI chr 7:52,858,313...52,865,454
Ensembl chr 7:52,858,305...52,865,635
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon increases expression EXP Ketoconazole results in increased expression of YWHAE mRNA CTD PMID:37077353 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589
JBrowse link
G Zar1 zygote arrest 1 decreases expression EXP Ketoconazole results in decreased expression of ZAR1 mRNA CTD PMID:36653537 NCBI chr14:35,193,446...35,197,382
Ensembl chr14:35,193,446...35,197,382
JBrowse link
G Zfp451 zinc finger protein 451 increases expression ISO Ketoconazole results in increased expression of ZFP451 mRNA CTD PMID:31099283 NCBI chr 9:35,985,441...36,040,991
Ensembl chr 9:35,985,443...36,040,652
JBrowse link
G Zfp518b zinc finger protein 518B increases expression ISO Ketoconazole results in increased expression of ZNF518B mRNA CTD PMID:36621641 NCBI chr14:72,121,085...72,140,479
Ensembl chr14:72,121,112...72,140,481
JBrowse link
G Zfp703 zinc finger protein 703 decreases expression EXP Ketoconazole results in decreased expression of ZFP703 mRNA CTD PMID:36653537 NCBI chr16:65,076,507...65,080,677
Ensembl chr16:65,076,507...65,080,677
JBrowse link
G Zfp709l1 zinc finger protein 709-like 1 decreases expression EXP Ketoconazole results in decreased expression of ZFP709L1 mRNA CTD PMID:36653537 NCBI chr 7:7,683,807...7,708,257
Ensembl chr 7:7,668,997...7,780,109
JBrowse link
G Zswim6 zinc finger, SWIM-type containing 6 increases expression ISO Ketoconazole results in increased expression of ZSWIM6 mRNA CTD PMID:36621641 NCBI chr 2:39,211,131...39,378,877
Ensembl chr 2:39,212,949...39,378,924
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    chemical entity 19916
      atom 19916
        nonmetal atom 19852
          oxygen atom 19586
            oxygen molecular entity 19586
              organooxygen compound 19217
                ether 17308
                  1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine 844
                    cis-1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine + 844
                    trans-1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                organic heterocyclic compound 18906
                                  heteroarene 17172
                                    monocyclic heteroarene 14893
                                      azole 14396
                                        diazole 10488
                                          imidazoles 9889
                                            1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine 844
                                              cis-1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine + 844
                                              trans-1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine + 0
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