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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tubercidin
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Accession:CHEBI:48267 term browser browse the term
Definition:An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus.
Synonyms:related_synonym: 7-Deazaadenosine;   7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;   Formula=C11H14N4O4;   InChI=1S/C11H14N4O4/c12-9-5-1-2-15(10(5)14-4-13-9)11-8(18)7(17)6(3-16)19-11/h1-2,4,6-8,11,16-18H,3H2,(H2,12,13,14)/t6-,7-,8-,11-/m1/s1;   InChIKey=HDZZVAMISRMYHH-KCGFPETGSA-N;   SMILES=[C@@H]1([C@@H]([C@H](O)[C@H](O1)CO)O)N2C=3N=CN=C(C3C=C2)N;   Sparsomycin A
 alt_id: CHEBI:45836
 xref: Beilstein:38498;   CAS:69-33-0;   DrugBank:DB03172;   MetaCyc:CPD-13054;   PDBeChem:TBN;   Patent:US4316957



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5-iodotubercidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases phosphorylation EXP 5-iodotubercidin results in decreased phosphorylation of CDKN1B protein CTD PMID:26953159 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Clk1 CDC-like kinase 1 decreases activity ISO 5-iodotubercidin results in decreased activity of CLK1 protein CTD PMID:26953159 NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000
JBrowse link
G Clk2 CDC-like kinase 2 decreases activity ISO 5-iodotubercidin results in decreased activity of CLK2 protein CTD PMID:26953159 NCBI chr 2:174,570,614...174,582,645 JBrowse link
G Clk3 CDC-like kinase 3 decreases activity ISO 5-iodotubercidin results in decreased activity of CLK3 protein CTD PMID:26953159 NCBI chr 8:58,152,155...58,167,196
Ensembl chr 8:58,152,155...58,168,181
JBrowse link
G Clk4 CDC-like kinase 4 decreases activity ISO 5-iodotubercidin results in decreased activity of CLK4 protein CTD PMID:26953159 NCBI chr10:35,523,382...35,541,387
Ensembl chr10:35,524,755...35,541,352
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases activity ISO 5-iodotubercidin results in decreased activity of DYRK1A protein CTD PMID:26953159 NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420
JBrowse link
G Dyrk1b dual specificity tyrosine phosphorylation regulated kinase 1B decreases activity ISO 5-iodotubercidin results in decreased activity of DYRK1B protein CTD PMID:26953159 NCBI chr 1:83,479,139...83,497,011
Ensembl chr 1:83,479,147...83,487,169
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 decreases activity ISO 5-iodotubercidin results in decreased activity of DYRK2 protein CTD PMID:26953159 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106
JBrowse link
G Dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 decreases activity ISO 5-iodotubercidin results in decreased activity of DYRK3 protein CTD PMID:26953159 NCBI chr13:42,594,120...42,604,898
Ensembl chr13:42,594,121...42,604,778
JBrowse link
G Dyrk4 dual specificity tyrosine phosphorylation regulated kinase 4 decreases activity ISO 5-iodotubercidin results in decreased activity of DYRK4 protein CTD PMID:26953159 NCBI chr 4:159,715,658...159,757,660
Ensembl chr 4:159,715,417...159,757,627
JBrowse link
G Ins2 insulin 2 increases secretion
affects secretion
ISO 5-iodotubercidin results in increased secretion of INS protein
5-iodotubercidin affects the secretion of INS protein
CTD PMID:26953159 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO 5-iodotubercidin results in increased expression of MMP3 mRNA CTD PMID:26953159 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Nefm neurofilament medium chain increases expression ISO 5-iodotubercidin results in increased expression of NEFM mRNA CTD PMID:26953159 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Olfm4 olfactomedin 4 decreases expression ISO 5-iodotubercidin results in decreased expression of OLFM4 mRNA CTD PMID:26953159 NCBI chr15:55,385,100...55,429,687
Ensembl chr15:55,407,148...55,429,681
JBrowse link
G Reg3b regenerating family member 3 beta decreases expression ISO 5-iodotubercidin results in decreased expression of REG3A mRNA CTD PMID:26953159 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases expression ISO 5-iodotubercidin results in increased expression of SLC2A2 mRNA CTD PMID:26953159 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        biochemical role 19390
          antimetabolite 8526
            tubercidin 16
              (Rp)-7-bromo-7-deaza-cAMPS 0
              (Rp)-7-deaza-cAMPS 0
              (Rp)-8-bromo-7-deaza-cAMPS 0
              (Sp)-7-bromo-7-deaza-cAMPS 0
              (Sp)-8-bromo-7-deaza-cAMPS 0
              5-iodotubercidin 16
              7-deaza-8-chloro-cAMP 0
              7-deaza-cAMP 0
              7-deaza-cGMP 0
              TuMP 0
              sangivamycic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            heteroorganic entity 19301
                              organochalcogen compound 19073
                                organooxygen compound 19024
                                  carbohydrates and carbohydrate derivatives 12345
                                    carbohydrate 12345
                                      carbohydrate derivative 11951
                                        glycosyl compound 10983
                                          N-glycosyl compound 5520
                                            nucleoside 5381
                                              ribonucleoside 678
                                                tubercidin 16
                                                  (Rp)-7-bromo-7-deaza-cAMPS 0
                                                  (Rp)-7-deaza-cAMPS 0
                                                  (Rp)-8-bromo-7-deaza-cAMPS 0
                                                  (Sp)-7-bromo-7-deaza-cAMPS 0
                                                  (Sp)-8-bromo-7-deaza-cAMPS 0
                                                  5-iodotubercidin 16
                                                  7-deaza-8-chloro-cAMP 0
                                                  7-deaza-cAMP 0
                                                  7-deaza-cGMP 0
                                                  TuMP 0
                                                  sangivamycic acid 0
paths to the root