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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tubercidin
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Accession:CHEBI:48267 term browser browse the term
Definition:An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus.
Synonyms:related_synonym: 7-Deazaadenosine;   7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;   Formula=C11H14N4O4;   InChI=1S/C11H14N4O4/c12-9-5-1-2-15(10(5)14-4-13-9)11-8(18)7(17)6(3-16)19-11/h1-2,4,6-8,11,16-18H,3H2,(H2,12,13,14)/t6-,7-,8-,11-/m1/s1;   InChIKey=HDZZVAMISRMYHH-KCGFPETGSA-N;   SMILES=[C@@H]1([C@@H]([C@H](O)[C@H](O1)CO)O)N2C=3N=CN=C(C3C=C2)N;   Sparsomycin A
 alt_id: CHEBI:45836
 xref: Beilstein:38498;   CAS:69-33-0;   DrugBank:DB03172;   MetaCyc:CPD-13054;   PDBeChem:TBN;   Patent:US4316957


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5-iodotubercidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases phosphorylation EXP 5-iodotubercidin results in decreased phosphorylation of CDKN1B protein CTD PMID:26953159 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Clk1 CDC-like kinase 1 decreases activity ISO 5-iodotubercidin results in decreased activity of CLK1 protein CTD PMID:26953159 NCBI chr 9:65,296,777...65,308,017
Ensembl chr 9:65,296,778...65,307,995
JBrowse link
G Clk2 CDC-like kinase 2 decreases activity ISO 5-iodotubercidin results in decreased activity of CLK2 protein CTD PMID:26953159 NCBI chr 2:188,476,789...188,488,809
Ensembl chr 2:188,476,820...188,496,191
JBrowse link
G Clk3 CDC-like kinase 3 decreases activity ISO 5-iodotubercidin results in decreased activity of CLK3 protein CTD PMID:26953159 NCBI chr 8:62,528,135...62,543,550
Ensembl chr 8:62,528,225...62,542,622
JBrowse link
G Clk4 CDC-like kinase 4 decreases activity ISO 5-iodotubercidin results in decreased activity of CLK4 protein CTD PMID:26953159 NCBI chr10:36,715,565...36,733,473
Ensembl chr10:36,715,565...36,733,133
JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases activity ISO 5-iodotubercidin results in decreased activity of DYRK1A protein CTD PMID:26953159 NCBI chr11:34,858,339...34,958,733
Ensembl chr11:34,865,532...34,956,536
JBrowse link
G Dyrk1b dual specificity tyrosine phosphorylation regulated kinase 1B decreases activity ISO 5-iodotubercidin results in decreased activity of DYRK1B protein CTD PMID:26953159 NCBI chr 1:85,112,819...85,120,840
Ensembl chr 1:85,112,247...85,120,839
JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 decreases activity ISO 5-iodotubercidin results in decreased activity of DYRK2 protein CTD PMID:26953159 NCBI chr 7:61,785,423...61,816,775
Ensembl chr 7:61,786,309...61,798,729
JBrowse link
G Dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 decreases activity ISO 5-iodotubercidin results in decreased activity of DYRK3 protein CTD PMID:26953159 NCBI chr13:47,906,230...47,916,877
Ensembl chr13:47,906,231...47,916,877
JBrowse link
G Dyrk4 dual specificity tyrosine phosphorylation regulated kinase 4 decreases activity ISO 5-iodotubercidin results in decreased activity of DYRK4 protein CTD PMID:26953159 NCBI chr 4:159,426,447...159,467,973
Ensembl chr 4:159,427,340...159,467,955
JBrowse link
G Ins2 insulin 2 increases secretion
affects secretion
ISO 5-iodotubercidin results in increased secretion of INS protein
5-iodotubercidin affects the secretion of INS protein
CTD PMID:26953159 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO 5-iodotubercidin results in increased expression of MMP3 mRNA CTD PMID:26953159 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Nefm neurofilament medium increases expression ISO 5-iodotubercidin results in increased expression of NEFM mRNA CTD PMID:26953159 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
JBrowse link
G Olfm4 olfactomedin 4 decreases expression ISO 5-iodotubercidin results in decreased expression of OLFM4 mRNA CTD PMID:26953159 NCBI chr15:62,384,263...62,429,450
Ensembl chr15:62,406,873...62,429,449
JBrowse link
G Reg3b regenerating family member 3 beta decreases expression ISO 5-iodotubercidin results in decreased expression of REG3A mRNA CTD PMID:26953159 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases expression ISO 5-iodotubercidin results in increased expression of SLC2A2 mRNA CTD PMID:26953159 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          antimetabolite 8484
            tubercidin 16
              (Rp)-7-bromo-7-deaza-cAMPS 0
              (Rp)-7-deaza-cAMPS 0
              (Rp)-8-bromo-7-deaza-cAMPS 0
              (Sp)-7-bromo-7-deaza-cAMPS 0
              (Sp)-8-bromo-7-deaza-cAMPS 0
              5-iodotubercidin 16
              7-deaza-8-chloro-cAMP 0
              7-deaza-cAMP 0
              7-deaza-cGMP 0
              TuMP 0
              sangivamycic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            heteroorganic entity 19147
                              organochalcogen compound 18855
                                organooxygen compound 18777
                                  carbohydrates and carbohydrate derivatives 12178
                                    carbohydrate 12178
                                      carbohydrate derivative 11802
                                        glycosyl compound 10846
                                          N-glycosyl compound 5334
                                            nucleoside 5194
                                              ribonucleoside 690
                                                tubercidin 16
                                                  (Rp)-7-bromo-7-deaza-cAMPS 0
                                                  (Rp)-7-deaza-cAMPS 0
                                                  (Rp)-8-bromo-7-deaza-cAMPS 0
                                                  (Sp)-7-bromo-7-deaza-cAMPS 0
                                                  (Sp)-8-bromo-7-deaza-cAMPS 0
                                                  5-iodotubercidin 16
                                                  7-deaza-8-chloro-cAMP 0
                                                  7-deaza-cAMP 0
                                                  7-deaza-cGMP 0
                                                  TuMP 0
                                                  sangivamycic acid 0
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