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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:frenolicin B
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Accession:CHEBI:48201 term browser browse the term
Definition:A benzoisochromanequinone that has formula C18H16O6.
Synonyms:exact_synonym: (3aR,5R,11bR)-7-hydroxy-5-propyl-3,3a,5,11b-tetrahydro-2H-furo[3,2-b]naphtho[2,3-d]pyran-2,6,11-trione
 related_synonym: Formula=C18H16O6;   InChI=1S/C18H16O6/c1-2-4-10-14-15(18-11(23-10)7-12(20)24-18)16(21)8-5-3-6-9(19)13(8)17(14)22/h3,5-6,10-11,18-19H,2,4,7H2,1H3/t10-,11-,18+/m1/s1;   InChIKey=AVCPRTNVVRPELB-YRUZYCQGSA-N;   SMILES=[H][C@@]12CC(=O)O[C@]1([H])C1=C([C@@H](CCC)O2)C(=O)c2c(O)cccc2C1=O
 xref: Beilstein:6436493;   CAS:68930-68-7
 xref_mesh: MESH:C018066



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frenolicin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO frenolicin B binds to and results in decreased activity of AKT1 protein CTD PMID:19309081 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions
ISO frenolicin B results in decreased phosphorylation of EIF4EBP1 protein
Acetylcysteine inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]; GLRX3 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]; PRDX1 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]
CTD PMID:30661989 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Glrx3 glutaredoxin 3 multiple interactions ISO [frenolicin B results in decreased activity of GLRX3 protein] which results in decreased abundance of Glutathione; [frenolicin B results in decreased activity of GLRX3 protein] which results in increased abundance of Hydrogen Peroxide; [frenolicin B results in decreased activity of GLRX3 protein] which results in increased abundance of Reactive Oxygen Species; frenolicin B binds to and results in decreased activity of GLRX3 protein; GLRX3 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:30661989 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [frenolicin B results in increased cleavage of PARP1 protein] CTD PMID:30661989 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO [frenolicin B results in decreased activity of PRDX1 protein] which results in decreased abundance of Glutathione; [frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Hydrogen Peroxide; [frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Reactive Oxygen Species; Acetylcysteine inhibits the reaction [[frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Reactive Oxygen Species]; frenolicin B binds to and results in decreased activity of PRDX1 protein; PRDX1 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:30661989 NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO frenolicin B results in decreased phosphorylation of RPS6KB1 protein CTD PMID:30661989 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          metabolite 19631
            frenolicin B 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      ketone 17115
                                        cyclic ketone 15670
                                          quinone 8521
                                            p-quinones 8427
                                              frenolicin B 6
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