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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:frenolicin B
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Accession:CHEBI:48201 term browser browse the term
Definition:A benzoisochromanequinone that has formula C18H16O6.
Synonyms:exact_synonym: (3aR,5R,11bR)-7-hydroxy-5-propyl-3,3a,5,11b-tetrahydro-2H-furo[3,2-b]naphtho[2,3-d]pyran-2,6,11-trione
 related_synonym: Formula=C18H16O6;   InChI=1S/C18H16O6/c1-2-4-10-14-15(18-11(23-10)7-12(20)24-18)16(21)8-5-3-6-9(19)13(8)17(14)22/h3,5-6,10-11,18-19H,2,4,7H2,1H3/t10-,11-,18+/m1/s1;   InChIKey=AVCPRTNVVRPELB-YRUZYCQGSA-N;   SMILES=[H][C@@]12CC(=O)O[C@]1([H])C1=C([C@@H](CCC)O2)C(=O)c2c(O)cccc2C1=O
 xref: Beilstein:6436493;   CAS:68930-68-7
 xref_mesh: MESH:C018066


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frenolicin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO frenolicin B binds to and results in decreased activity of AKT1 protein CTD PMID:19309081 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions		 ISO frenolicin B results in decreased phosphorylation of EIF4EBP1 protein
Acetylcysteine inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]; GLRX3 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]; PRDX1 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]		 CTD PMID:30661989 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Glrx3 glutaredoxin 3 multiple interactions ISO [frenolicin B results in decreased activity of GLRX3 protein] which results in decreased abundance of Glutathione; [frenolicin B results in decreased activity of GLRX3 protein] which results in increased abundance of Hydrogen Peroxide; [frenolicin B results in decreased activity of GLRX3 protein] which results in increased abundance of Reactive Oxygen Species; frenolicin B binds to and results in decreased activity of GLRX3 protein; GLRX3 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:30661989 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO Acetylcysteine inhibits the reaction [frenolicin B results in increased cleavage of PARP1 protein] CTD PMID:30661989 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO [frenolicin B results in decreased activity of PRDX1 protein] which results in decreased abundance of Glutathione; [frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Hydrogen Peroxide; [frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Reactive Oxygen Species; Acetylcysteine inhibits the reaction [[frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Reactive Oxygen Species]; frenolicin B binds to and results in decreased activity of PRDX1 protein; PRDX1 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:30661989 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO frenolicin B results in decreased phosphorylation of RPS6KB1 protein CTD PMID:30661989 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      biological role 19878
        biochemical role 19586
          metabolite 19573
            frenolicin B 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            heteroorganic entity 19540
                              organochalcogen compound 19301
                                organooxygen compound 19216
                                  carbonyl compound 18947
                                    ketone 17281
                                      cyclic ketone 15929
                                        quinone 9916
                                          p-quinones 8579
                                            frenolicin B 6
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