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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclosiloxane
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Accession:CHEBI:48144 term browser browse the term
Definition:Compounds having rings of alternating silicon and oxygen atoms.
Synonyms:related_synonym: Zyklosiloxan;   Zyklosiloxane;   cyclosiloxanes



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octamethylcyclotetrasiloxane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase decreases expression ISO octamethylcyclotetrasiloxane results in decreased expression of ATM mRNA CTD PMID:27601420 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atr ATR serine/threonine kinase decreases expression ISO octamethylcyclotetrasiloxane results in decreased expression of ATR mRNA CTD PMID:27601420 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
affects expression
ISO octamethylcyclotetrasiloxane results in decreased expression of BRCA1 protein
octamethylcyclotetrasiloxane affects the expression of BRCA1 mRNA
CTD PMID:27601420 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brca2 BRCA2, DNA repair associated decreases expression ISO octamethylcyclotetrasiloxane results in decreased expression of BRCA2 mRNA CTD PMID:27601420 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO octamethylcyclotetrasiloxane results in decreased expression of CHEK1 mRNA CTD PMID:27601420 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO octamethylcyclotetrasiloxane results in decreased expression of CHEK2 mRNA CTD PMID:27601420 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP octamethylcyclotetrasiloxane results in decreased expression of and results in increased activity of CYP1A1 protein CTD PMID:36100151 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP octamethylcyclotetrasiloxane results in decreased expression of and results in increased activity of CYP1A2 protein CTD PMID:36100151 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
multiple interactions
EXP octamethylcyclotetrasiloxane results in increased expression of CYP2B1 protein
octamethylcyclotetrasiloxane results in increased expression of and results in increased activity of CYP2B1 protein
CTD PMID:15849718 PMID:36100151 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression
multiple interactions
EXP octamethylcyclotetrasiloxane results in increased expression of CYP2B2 protein
octamethylcyclotetrasiloxane results in increased expression of and results in increased activity of CYP2B2 protein
CTD PMID:15849718 PMID:36100151 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
EXP octamethylcyclotetrasiloxane results in increased expression of CYP3A2 protein
octamethylcyclotetrasiloxane results in increased expression of and results in increased activity of CYP3A2 protein
CTD PMID:15849718 PMID:36100151 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression
multiple interactions
EXP octamethylcyclotetrasiloxane results in increased expression of CYP3A23-3A1 protein
octamethylcyclotetrasiloxane results in increased expression of and results in increased activity of CYP3A23-3A1 protein
CTD PMID:15849718 PMID:36100151 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO octamethylcyclotetrasiloxane binds to and results in increased activity of ESR1 protein CTD PMID:17175556 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity ISO octamethylcyclotetrasiloxane results in increased activity of GPT protein CTD PMID:9924013 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO octamethylcyclotetrasiloxane results in increased activity of NR1I2 protein CTD PMID:25680588 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO octamethylcyclotetrasiloxane results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      atom 19909
        metalloid atom 14282
          silicon atom 5759
            silicon molecular entity 5755
              cyclosiloxane 16
                2,2-dimethylcyclotrisiloxane 0
                2-methylcyclotrisiloxane 0
                cyclotetrasiloxane + 16
                cyclotrisiloxane + 0
                octamethylcyclotetrasiloxane 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19909
          baryon 19909
            nucleon 19909
              atomic nucleus 19909
                atom 19909
                  group 19868
                    polyatomic entity 19867
                      molecule 19768
                        cyclic compound 19576
                          heterocyclic compound 18901
                            cyclosiloxane 16
                              2,2-dimethylcyclotrisiloxane 0
                              2-methylcyclotrisiloxane 0
                              cyclotetrasiloxane + 16
                              cyclotrisiloxane + 0
                              octamethylcyclotetrasiloxane 16
paths to the root