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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyclosiloxane
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Accession:CHEBI:48144 term browser browse the term
Definition:Compounds having rings of alternating silicon and oxygen atoms.
Synonyms:related_synonym: Zyklosiloxan;   Zyklosiloxane;   cyclosiloxanes



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octamethylcyclotetrasiloxane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase decreases expression ISO octamethylcyclotetrasiloxane results in decreased expression of ATM mRNA CTD PMID:27601420 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atr ATR serine/threonine kinase decreases expression ISO octamethylcyclotetrasiloxane results in decreased expression of ATR mRNA CTD PMID:27601420 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
affects expression
ISO octamethylcyclotetrasiloxane results in decreased expression of BRCA1 protein
octamethylcyclotetrasiloxane affects the expression of BRCA1 mRNA
CTD PMID:27601420 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brca2 BRCA2, DNA repair associated decreases expression ISO octamethylcyclotetrasiloxane results in decreased expression of BRCA2 mRNA CTD PMID:27601420 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO octamethylcyclotetrasiloxane results in decreased expression of CHEK1 mRNA CTD PMID:27601420 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO octamethylcyclotetrasiloxane results in decreased expression of CHEK2 mRNA CTD PMID:27601420 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP octamethylcyclotetrasiloxane results in increased expression of CYP2B1 protein CTD PMID:15849718 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP octamethylcyclotetrasiloxane results in increased expression of CYP2B2 protein CTD PMID:15849718 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression EXP octamethylcyclotetrasiloxane results in increased expression of CYP3A2 protein CTD PMID:15849718 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP octamethylcyclotetrasiloxane results in increased expression of CYP3A23-3A1 protein CTD PMID:15849718 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO octamethylcyclotetrasiloxane binds to and results in increased activity of ESR1 protein CTD PMID:17175556 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity ISO octamethylcyclotetrasiloxane results in increased activity of GPT protein CTD PMID:9924013 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO octamethylcyclotetrasiloxane results in increased activity of NR1I2 protein CTD PMID:25680588 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO octamethylcyclotetrasiloxane results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19659
    chemical entity 19658
      atom 19658
        metalloid atom 13579
          silicon atom 5568
            silicon molecular entity 5564
              cyclosiloxane 14
                2,2-dimethylcyclotrisiloxane 0
                2-methylcyclotrisiloxane 0
                cyclotetrasiloxane + 14
                cyclotrisiloxane + 0
                octamethylcyclotetrasiloxane 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  group 19661
                    polyatomic entity 19617
                      molecule 19525
                        cyclic compound 19383
                          heterocyclic compound 18682
                            cyclosiloxane 14
                              2,2-dimethylcyclotrisiloxane 0
                              2-methylcyclotrisiloxane 0
                              cyclotetrasiloxane + 14
                              cyclotrisiloxane + 0
                              octamethylcyclotetrasiloxane 14
paths to the root