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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:eprosartan
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Accession:CHEBI:4814 term browser browse the term
Definition:A member of the class of imidazoles and thiophenes that is an angiotensin II receptor antagonist used for the treatment of high blood pressure.
Synonyms:exact_synonym: 4-({2-butyl-5-[(1E)-2-carboxy-3-(2-thienyl)prop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid
 related_synonym: (E)-2-butyl-1-(p-carboxybenzyl)-alpha-2-thenylimidazole-5-acrylic acid;   (E)-3-[2-n-butyl-1-{(4-carboxyphenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic acid;   (E)-alpha{[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazole-5-yl]methylene}-2-thiopheneproprionic acid;   Formula=C23H24N2O4S;   InChI=1S/C23H24N2O4S/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-30-20)25(21)15-16-7-9-17(10-8-16)22(26)27/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)(H,28,29)/b18-12+;   InChIKey=OROAFUQRIXKEMV-LDADJPATSA-N;   SMILES=CCCCc1ncc(\\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(cc1)C(O)=O
 xref: Beilstein:4338002;   CAS:133040-01-4;   DrugBank:DB00876;   Drug_Central:1037;   KEGG:C07467;   KEGG:D04040;   Patent:EP403159;   Patent:US5185351;   Reaxys:4338002;   Wikipedia:Eprosartan



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eprosartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain decreases expression EXP eprosartan decreases expression of collagen I-a1 mRNA in high fat high sodium fed SHRSP/A3N rat kidney RGD PMID:11907153 RGD:28912746 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression EXP eprosartan decreases expression of collagen III mRNA in high fat high sodium fed SHRSP/A3N rat kidney RGD PMID:11907153 RGD:28912746 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Fn1 fibronectin 1 decreases expression EXP eprosartan decreases expression of fibronectin mRNA in high fat high sodium fed SHRSP/A3N rat kidney RGD PMID:11907153 RGD:28912746 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Serpine1 serpin family E member 1 decreases expression EXP eprosartan decreases expression of plasminogen activator inhibitor -1 mRNA in high fat high sodium fed SHRSP/A3N rat kidney RGD PMID:11907153 RGD:28912746 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP eprosartan decreases expression of TGFbeta mRNA in high fat high sodium fed SHRSP/A3N rat kidney RGD PMID:11907153 RGD:28912746 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        xenobiotic 18613
          eprosartan 5
            eprosartan methanesulfonate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic molecule 19587
                              organic cyclic compound 19393
                                organic heterocyclic compound 18766
                                  heteroarene 16882
                                    monocyclic heteroarene 14240
                                      azole 13601
                                        diazole 8632
                                          imidazoles 7731
                                            eprosartan 5
                                              eprosartan methanesulfonate 0
paths to the root