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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrroloindole
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Accession:CHEBI:48133 term browser browse the term
Synonyms:related_synonym: pyrroloindoles


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SB 206553 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP SB 206553 inhibits the reaction [Fluoxetine results in increased expression of FOS protein] CTD PMID:16521035 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions EXP [volinanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [SB 206553 results in increased susceptibility to Methamphetamine] CTD PMID:11751031 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B multiple interactions EXP SB 206553 binds to and results in decreased activity of HTR2B protein CTD PMID:16521035 NCBI chr 9:93,112,781...93,130,135
Ensembl chr 9:93,112,805...93,125,014
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases expression
multiple interactions
ISO
EXP
SB 206553 results in increased expression of HTR2C protein
SB 206553 binds to and results in decreased activity of HTR2C protein
CTD PMID:16521035, PMID:18083778 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO SB 206553 inhibits the reaction [Isoproterenol results in increased expression of IL1B] CTD PMID:15302781 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO SB 206553 inhibits the reaction [Isoproterenol results in increased expression of IL6] CTD PMID:15302781 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO SB 206553 inhibits the reaction [Isoproterenol results in increased expression of TNF] CTD PMID:15302781 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
Sporidesmin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 affects localization ISO sporidesmin affects the localization of CTNNB1 protein CTD PMID:28193462 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects expression ISO sporidesmin affects the expression of CYP1A2 mRNA CTD PMID:28193462 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions
increases expression
ISO MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
sporidesmin results in increased expression of CYP2C18 mRNA; sporidesmin results in increased expression of CYP2C18 protein
CTD PMID:28193462 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects expression
multiple interactions
ISO sporidesmin affects the expression of CYP2C8 mRNA
MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA]
CTD PMID:28193462 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 decreases expression ISO sporidesmin results in decreased expression of DKK3 mRNA CTD PMID:28193462 NCBI chr 1:176,940,424...176,983,076
Ensembl chr 1:176,940,693...176,983,045
JBrowse link
G Mir132 microRNA 132 increases expression ISO sporidesmin results in increased expression of MIR132 mRNA CTD PMID:28193462 NCBI chr10:62,014,995...62,015,095
Ensembl chr10:62,014,995...62,015,095
JBrowse link
G Mir138-2 microRNA 138-2 increases expression ISO sporidesmin results in increased expression of MIR138-2 mRNA alternative form CTD PMID:28193462 NCBI chr19:11,149,748...11,149,829
Ensembl chr19:11,149,748...11,149,829
JBrowse link
G Mir139 microRNA 139 increases expression ISO sporidesmin results in increased expression of MIR139 mRNA CTD PMID:28193462 NCBI chr 1:166,589,545...166,589,612
Ensembl chr 1:166,589,545...166,589,612
JBrowse link
G Mir150 microRNA 150 increases expression ISO sporidesmin results in increased expression of MIR150 mRNA CTD PMID:28193462 NCBI chr 1:101,115,974...101,116,058
Ensembl chr 1:101,115,974...101,116,058
JBrowse link
G Mir184 microRNA 184 increases expression ISO sporidesmin results in increased expression of MIR184 mRNA CTD PMID:28193462 NCBI chr 8:97,175,657...97,175,733
Ensembl chr 8:97,175,657...97,175,733
JBrowse link
G Mir21 microRNA 21 increases expression
multiple interactions
ISO sporidesmin results in increased expression of MIR21 mRNA
MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA]; MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
CTD PMID:28193462 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir290 microRNA 290 increases expression ISO sporidesmin results in increased expression of MIR371A mRNA CTD PMID:28193462 NCBI chr 1:64,538,705...64,538,785
Ensembl chr 1:64,538,705...64,538,785
JBrowse link
G Mir295-1 microRNA 295-1 increases expression ISO sporidesmin results in increased expression of MIR372 mRNA CTD PMID:28193462 NCBI chr 1:64,536,623...64,536,703
Ensembl chr 1:64,536,623...64,536,703
JBrowse link
G Mir31 microRNA 31 multiple interactions
increases expression
ISO MIR31 mRNA affects the reaction [sporidesmin affects the expression of WIF1 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in decreased expression of SFRP1 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
sporidesmin results in increased expression of MIR31 mRNA
CTD PMID:28193462 NCBI chr 5:107,206,515...107,206,620 JBrowse link
G Mir375 microRNA 375 increases expression ISO sporidesmin results in increased expression of MIR375 mRNA CTD PMID:28193462 NCBI chr 9:82,161,716...82,161,790
Ensembl chr 9:82,161,716...82,161,790
JBrowse link
G Mir409 microRNA 409 increases expression ISO sporidesmin results in increased expression of MIR409 mRNA CTD PMID:28193462 NCBI chr 6:133,893,419...133,893,495 JBrowse link
G Mir487b microRNA 487b increases expression ISO sporidesmin results in increased expression of MIR487B mRNA CTD PMID:28193462 NCBI chr 6:133,877,124...133,877,205
Ensembl chr 6:133,877,124...133,877,205
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 decreases expression
multiple interactions
ISO sporidesmin results in decreased expression of SFRP1 mRNA
MIR31 mRNA affects the reaction [sporidesmin results in decreased expression of SFRP1 mRNA]
CTD PMID:28193462 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777
JBrowse link
G Wif1 Wnt inhibitory factor 1 multiple interactions
affects expression
ISO MIR31 mRNA affects the reaction [sporidesmin affects the expression of WIF1 mRNA] CTD PMID:28193462 NCBI chr 7:63,094,955...63,165,158
Ensembl chr 7:63,094,911...63,165,159
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19801
    chemical entity 19800
      atom 19797
        nonmetal atom 19672
          nitrogen atom 18563
            nitrogen molecular entity 18563
              organonitrogen compound 18336
                organonitrogen heterocyclic compound 17483
                  pyrroloindole 26
                    (3aS,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-ol 0
                    5'-O-[(S)-\{[6-(\{[6-(\{6-[(6-carbamoyl-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl\}carbonyl)-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl]carbonyl\}amino)hexyl]oxy\}(hydroxy)phosphoryl]thymidine 0
                    Auricularine 0
                    Borreverine 0
                    Eseramine 0
                    Hodgkinsine 0
                    LSM-6198 0
                    Me-YTM-T 0
                    N-methylcarbamic acid [(8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] ester 0
                    Psychotridine 0
                    Quadrigemine A 0
                    SB 206553 7
                    Sporidesmin 19
                    Sporidesmin J 0
                    Verticillin G 0
                    YTM-T 0
                    [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate 0
                    chimonanthine + 0
                    eseroline + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19801
    subatomic particle 19797
      composite particle 19797
        hadron 19797
          baryon 19797
            nucleon 19797
              atomic nucleus 19797
                atom 19797
                  main group element atom 19684
                    p-block element atom 19684
                      carbon group element atom 19583
                        carbon atom 19572
                          organic molecular entity 19572
                            organic molecule 19494
                              organic cyclic compound 19264
                                organic heterocyclic compound 18431
                                  organic heteropolycyclic compound 17843
                                    organic heterotricyclic compound 14588
                                      pyrroloindole 26
                                        (3aS,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-ol 0
                                        5'-O-[(S)-\{[6-(\{[6-(\{6-[(6-carbamoyl-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl\}carbonyl)-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl]carbonyl\}amino)hexyl]oxy\}(hydroxy)phosphoryl]thymidine 0
                                        Auricularine 0
                                        Borreverine 0
                                        Eseramine 0
                                        Hodgkinsine 0
                                        LSM-6198 0
                                        Me-YTM-T 0
                                        N-methylcarbamic acid [(8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] ester 0
                                        Psychotridine 0
                                        Quadrigemine A 0
                                        SB 206553 7
                                        Sporidesmin 19
                                        Sporidesmin J 0
                                        Verticillin G 0
                                        YTM-T 0
                                        [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate 0
                                        chimonanthine + 0
                                        eseroline + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.