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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrroloindole
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Accession:CHEBI:48133 term browser browse the term
Synonyms:related_synonym: pyrroloindoles


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SB 206553 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP SB 206553 inhibits the reaction [Fluoxetine results in increased expression of FOS protein] CTD PMID:16521035 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions EXP [volinanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [SB 206553 results in increased susceptibility to Methamphetamine] CTD PMID:11751031 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B multiple interactions EXP SB 206553 binds to and results in decreased activity of HTR2B protein CTD PMID:16521035 NCBI chr 9:86,735,793...86,756,640
Ensembl chr 9:86,742,102...86,755,108
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases expression
multiple interactions
ISO
EXP
SB 206553 results in increased expression of HTR2C protein
SB 206553 binds to and results in decreased activity of HTR2C protein
CTD PMID:16521035 PMID:18083778 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO SB 206553 inhibits the reaction [Isoproterenol results in increased expression of IL1B] CTD PMID:15302781 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO SB 206553 inhibits the reaction [Isoproterenol results in increased expression of IL6] CTD PMID:15302781 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO SB 206553 inhibits the reaction [Isoproterenol results in increased expression of TNF] CTD PMID:15302781 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
Sporidesmin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 affects localization ISO sporidesmin affects the localization of CTNNB1 protein CTD PMID:28193462 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects expression ISO sporidesmin affects the expression of CYP1A2 mRNA CTD PMID:28193462 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases expression ISO sporidesmin results in increased expression of CYP2C9 mRNA CTD PMID:28193462 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions
increases expression
ISO MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
sporidesmin results in increased expression of CYP2C18 mRNA; sporidesmin results in increased expression of CYP2C18 protein
CTD PMID:28193462 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects expression
multiple interactions
ISO sporidesmin affects the expression of CYP2C8 mRNA
MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA]
CTD PMID:28193462
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 decreases expression ISO sporidesmin results in decreased expression of DKK3 mRNA CTD PMID:28193462 NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590
JBrowse link
G Mir132 microRNA 132 increases expression ISO sporidesmin results in increased expression of MIR132 mRNA CTD PMID:28193462 NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796
JBrowse link
G Mir138-2 microRNA 138-2 increases expression ISO sporidesmin results in increased expression of MIR138-2 mRNA alternative form CTD PMID:28193462 NCBI chr19:10,674,193...10,674,274
Ensembl chr19:10,674,193...10,674,274
JBrowse link
G Mir139 microRNA 139 increases expression ISO sporidesmin results in increased expression of MIR139 mRNA CTD PMID:28193462 NCBI chr 1:155,878,828...155,878,895
Ensembl chr 1:155,878,825...155,878,902
JBrowse link
G Mir150 microRNA 150 increases expression ISO sporidesmin results in increased expression of MIR150 mRNA CTD PMID:28193462 NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108
JBrowse link
G Mir184 microRNA 184 increases expression ISO sporidesmin results in increased expression of MIR184 mRNA CTD PMID:28193462 NCBI chr 8:90,343,134...90,343,210
Ensembl chr 8:90,343,134...90,343,210
JBrowse link
G Mir21 microRNA 21 increases expression
multiple interactions
ISO sporidesmin results in increased expression of MIR21 mRNA
MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA]; MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
CTD PMID:28193462 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir290 microRNA 290 increases expression ISO sporidesmin results in increased expression of MIR371A mRNA CTD PMID:28193462 NCBI chr 1:65,964,648...65,964,728
Ensembl chr 1:65,964,648...65,964,728
JBrowse link
G Mir295-1 microRNA 295-1 increases expression ISO sporidesmin results in increased expression of MIR372 mRNA CTD PMID:28193462 NCBI chr 1:65,962,566...65,962,646 JBrowse link
G Mir31 microRNA 31 multiple interactions
increases expression
ISO MIR31 mRNA affects the reaction [sporidesmin affects the expression of WIF1 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in decreased expression of SFRP1 mRNA]; MIR31 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]
sporidesmin results in increased expression of MIR31 mRNA
CTD PMID:28193462 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Mir375 microRNA 375 increases expression ISO sporidesmin results in increased expression of MIR375 mRNA CTD PMID:28193462 NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985
JBrowse link
G Mir409 microRNA 409 increases expression ISO sporidesmin results in increased expression of MIR409 mRNA CTD PMID:28193462 NCBI chr 6:128,757,780...128,757,856 JBrowse link
G Mir487b microRNA 487b increases expression ISO sporidesmin results in increased expression of MIR487B mRNA CTD PMID:28193462 NCBI chr 6:128,741,485...128,741,566
Ensembl chr 6:128,741,485...128,741,566
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 decreases expression
multiple interactions
ISO sporidesmin results in decreased expression of SFRP1 mRNA
MIR31 mRNA affects the reaction [sporidesmin results in decreased expression of SFRP1 mRNA]
CTD PMID:28193462 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
JBrowse link
G Wif1 Wnt inhibitory factor 1 multiple interactions
affects expression
ISO MIR31 mRNA affects the reaction [sporidesmin affects the expression of WIF1 mRNA] CTD PMID:28193462 NCBI chr 7:56,548,058...56,618,364
Ensembl chr 7:56,548,053...56,618,360
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      atom 19811
        nonmetal atom 19698
          nitrogen atom 18761
            nitrogen molecular entity 18761
              organonitrogen compound 18533
                organonitrogen heterocyclic compound 17639
                  pyrroloindole 27
                    (3aS,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-ol 0
                    5'-O-[(S)-\{[6-(\{[6-(\{6-[(6-carbamoyl-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl\}carbonyl)-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl]carbonyl\}amino)hexyl]oxy\}(hydroxy)phosphoryl]thymidine 0
                    Auricularine 0
                    Borreverine 0
                    Eseramine 0
                    Hodgkinsine 0
                    LSM-6198 0
                    Me-YTM-T 0
                    N-methylcarbamic acid [(8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] ester 0
                    Psychotridine 0
                    Quadrigemine A 0
                    SB 206553 7
                    Sporidesmin 20
                    Sporidesmin J 0
                    Verticillin G 0
                    YTM-T 0
                    [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate 0
                    chimonanthine + 0
                    cyclic 3-Hydroxymelatonin 0
                    cyclic 6-Hydroxymelatonin 0
                    eseroline + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organic heteropolycyclic compound 18059
                                    organic heterotricyclic compound 14650
                                      pyrroloindole 27
                                        (3aS,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-ol 0
                                        5'-O-[(S)-\{[6-(\{[6-(\{6-[(6-carbamoyl-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl\}carbonyl)-3,6,7,8-tetrahydropyrrolo[3,2-e]indol-2-yl]carbonyl\}amino)hexyl]oxy\}(hydroxy)phosphoryl]thymidine 0
                                        Auricularine 0
                                        Borreverine 0
                                        Eseramine 0
                                        Hodgkinsine 0
                                        LSM-6198 0
                                        Me-YTM-T 0
                                        N-methylcarbamic acid [(8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] ester 0
                                        Psychotridine 0
                                        Quadrigemine A 0
                                        SB 206553 7
                                        Sporidesmin 20
                                        Sporidesmin J 0
                                        Verticillin G 0
                                        YTM-T 0
                                        [(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate 0
                                        chimonanthine + 0
                                        cyclic 3-Hydroxymelatonin 0
                                        cyclic 6-Hydroxymelatonin 0
                                        eseroline + 0
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