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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetracenomycin
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Accession:CHEBI:48132 term browser browse the term
Definition:A polyketide based on a tetracene ring structure.
Synonyms:related_synonym: tetracenomycins


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minocycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
decreases secretion
EXP
ISO
Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of and results in increased localization of AIFM1 protein]
Minocycline inhibits the reaction [Kainic Acid results in increased localization of AIFM1 protein]
Minocycline results in decreased secretion of AIFM1 protein
CTD PMID:12930891, PMID:16469440 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO
EXP
Minocycline inhibits the reaction [APP gene mutant form results in increased phosphorylation of EIF2S1 protein]
Minocycline inhibits the reaction [APP protein alternative form results in increased activity of CASP12 protein]; Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2AK2 protein]; Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2S1 protein]
CTD PMID:17406652 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions EXP Minocycline inhibits the reaction [Paclitaxel results in increased expression of ATF3 protein] CTD PMID:21050491 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of ATF6 protein] CTD PMID:22245251 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein] CTD PMID:23562983 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in decreased expression of ATP5H protein] CTD PMID:21561882 NCBI chr10:103,967,340...103,972,552
Ensembl chr10:103,967,312...103,972,668
JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO Minocycline inhibits the reaction [Copper results in increased expression of BACE1 mRNA] CTD PMID:18583042 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP [Minocycline results in increased expression of BCL2 protein] which binds to BAK1 protein CTD PMID:15004018 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
EXP [Minocycline results in increased expression of BCL2 protein] which binds to BAX protein; Minocycline inhibits the reaction [Sodium Azide affects the localization of BAX protein]
Minocycline results in decreased expression of BAX protein
CTD PMID:15004018, PMID:15172883 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO
EXP
[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2 protein] results in increased expression of BCL2 mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of BCL2 protein
Minocycline results in increased expression of BCL2 mRNA; Minocycline results in increased expression of BCL2 protein
[Minocycline results in increased expression of BCL2 protein] which binds to BAK1 protein; [Minocycline results in increased expression of BCL2 protein] which binds to BAX protein; [Minocycline results in increased expression of BCL2 protein] which binds to BID protein; Sodium Azide inhibits the reaction [Minocycline results in increased expression of BCL2 protein]
CTD PMID:15004018, PMID:19807907, PMID:20606027, PMID:20711699 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO
EXP
Minocycline results in decreased activity of and results in decreased cleavage of BID protein
[Minocycline results in increased expression of BCL2 protein] which binds to BID protein; Minocycline inhibits the reaction [HTT protein mutant form results in increased cleavage of and results in increased activity of BID protein]
CTD PMID:12930891, PMID:15004018 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp1 caspase 1 multiple interactions
decreases expression
decreases activity
EXP
ISO
Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP1 protein]
Minocycline results in decreased expression of CASP1 mRNA; Minocycline results in decreased expression of CASP1 protein
Minocycline results in decreased activity of CASP1 protein
CTD PMID:12930891, PMID:14998631 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp12 caspase 12 multiple interactions
decreases expression
EXP Minocycline inhibits the reaction [APP protein alternative form results in increased activity of CASP12 protein]; Minocycline results in decreased degradation of [Paraquat results in increased expression of CASP12 protein]
Minocycline results in decreased expression of CASP12 mRNA; Minocycline results in decreased expression of CASP12 protein
CTD PMID:14998631, PMID:17406652, PMID:22245251 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 decreases activity
decreases expression
multiple interactions
ISO
EXP
Minocycline results in decreased activity of CASP3 protein
Minocycline results in decreased expression of CASP3 mRNA
Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Sodium Azide results in increased activity of CASP3 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP3 protein
Minocycline inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]; Minocycline results in decreased activity of and results in decreased cleavage of CASP3 protein
CTD PMID:12930891, PMID:14588118, PMID:14998631, PMID:15004018, PMID:15304547, PMID:15564845, PMID:16469440, PMID:17872917, PMID:20711699, PMID:22245251 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 decreases expression
multiple interactions
EXP Minocycline results in decreased expression of CASP7 mRNA
Minocycline results in decreased expression of and results in decreased activity of CASP7 protein
CTD PMID:14998631 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
decreases expression
EXP Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP8 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP8 protein
Minocycline results in decreased expression of CASP8 mRNA
CTD PMID:12930891, PMID:14998631 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 decreases activity
decreases expression
multiple interactions
ISO
EXP
Minocycline results in decreased activity of CASP9 protein
Minocycline results in decreased expression of CASP9 mRNA
Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP9 protein]; Minocycline results in decreased expression of and results in decreased activity of CASP9 protein
CTD PMID:12930891, PMID:14998631 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO Minocycline results in decreased expression of CCL2 protein
Minocycline inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]
CTD PMID:20116850, PMID:24530660 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Minocycline results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Minocycline results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Minocycline results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Minocycline results in increased expression of CDKN1B mRNA; Minocycline results in increased expression of CDKN1B protein CTD PMID:21719015 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cldn5 claudin 5 increases expression EXP minocycline increases expression of claudin-5 protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein] CTD PMID:23562983 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
decreases secretion
ISO
EXP
Minocycline inhibits the reaction [Kainic Acid results in increased localization of CYCS protein]
Minocycline results in decreased secretion of CYCS protein
Minocycline inhibits the reaction [Cocaine results in increased secretion of CYCS protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of CYCS protein]
CTD PMID:12930891, PMID:14998631, PMID:15172883, PMID:16469440, PMID:21424555 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of DDIT3 protein] CTD PMID:22245251 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein decreases secretion
multiple interactions
ISO
EXP
Minocycline results in decreased secretion of DIABLO protein
Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of DIABLO protein]; Minocycline results in decreased secretion of and results in decreased expression of DIABLO protein
CTD PMID:12930891, PMID:14998631 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein] CTD PMID:23562983 NCBI chr 6:108,936,534...108,961,322
Ensembl chr 6:108,936,664...108,959,803
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 multiple interactions
increases expression
ISO [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein CTD PMID:24292262 NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 multiple interactions EXP Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2AK2 protein] CTD PMID:17406652 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation EXP Minocycline results in increased phosphorylation of EIF2AK3 protein CTD PMID:22245251 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
ISO
EXP
Minocycline inhibits the reaction [APP gene mutant form results in increased phosphorylation of EIF2S1 protein]
Minocycline results in increased phosphorylation of EIF2S1 protein
Minocycline inhibits the reaction [APP protein alternative form results in increased phosphorylation of EIF2S1 protein]
CTD PMID:17406652, PMID:22245251 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Eno1 enolase 1 multiple interactions ISO Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ENO1 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein] CTD PMID:23562983 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases phosphorylation EXP Minocycline results in increased phosphorylation of ERN1 protein CTD PMID:22245251 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions ISO Minocycline inhibits the reaction [FMR1 gene mutant form results in increased expression of and results in increased activity of MMP9 protein] CTD PMID:18835858 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Gjc2 gap junction protein, gamma 2 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of GJC2 protein modified form] CTD PMID:21561882 NCBI chr10:45,526,740...45,535,520
Ensembl chr10:45,526,745...45,534,570
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIA1 mRNA] CTD PMID:19660546 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2A mRNA] CTD PMID:19660546 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C multiple interactions EXP Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2C mRNA] CTD PMID:19660546 NCBI chr10:103,798,290...103,816,923
Ensembl chr10:103,798,291...103,816,287
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP minocycline increases expression of glutathione S-transferase pi protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases degradation
ISO [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein; Minocycline inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; Minocycline promotes the reaction [HIF1A protein binds to VHL protein]
Minocycline results in increased degradation of HIF1A protein
CTD PMID:24292262 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hp haptoglobin increases expression EXP minocycline increases expression of zonulin protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of HSPA5 protein] CTD PMID:22245251 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of HSPD1 protein] CTD PMID:21561882 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Htt huntingtin multiple interactions EXP Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP1 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP3 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP8 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased activity of CASP9 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased cleavage of and results in increased activity of BID protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of and results in increased localization of AIFM1 protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of CYCS protein]; Minocycline inhibits the reaction [HTT protein mutant form results in increased secretion of DIABLO protein] CTD PMID:12930891 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression EXP Minocycline results in decreased expression of ICAM1 protein CTD PMID:15172883 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG mRNA]
[Minocycline co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
CTD PMID:19285099, PMID:29594315 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO
EXP
Minocycline promotes the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]
Minocycline results in increased expression of IL10 mRNA
CTD PMID:14588118, PMID:22024136 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects secretion
ISO
EXP
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Minocycline inhibits the reaction [Kainic Acid results in increased secretion of IL1B protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of IL1B protein]; Minocycline inhibits the reaction [manganese chloride results in increased expression of IL1B protein]; Minocycline inhibits the reaction [Toluene results in increased expression of IL1B mRNA]
Minocycline affects the secretion of IL1B protein
CTD PMID:11306611, PMID:16386803, PMID:18836210, PMID:19285099, PMID:22024136, PMID:22952811, PMID:32234516 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Minocycline co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; Minocycline inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of IL6 protein] CTD PMID:19285099, PMID:21719015, PMID:24530660 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Minocycline results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of INA protein] CTD PMID:21561882 NCBI chr 1:266,782,835...266,794,389
Ensembl chr 1:266,781,617...266,794,431
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Minocycline results in decreased phosphorylation of and results in decreased activity of and results in decreased expression of JUN protein CTD PMID:17872917 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G LOC100364500 RT1 class I, locus CE11-like affects expression ISO Minocycline affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases phosphorylation ISO Minocycline results in decreased phosphorylation of MAPK8 protein CTD PMID:17872917 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in increased expression of MAPKAPK5 protein] CTD PMID:21561882 NCBI chr12:40,510,378...40,529,332
Ensembl chr12:40,510,378...40,529,338
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression
multiple interactions
ISO Minocycline results in increased expression of MMP13 mRNA
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP13 mRNA]
CTD PMID:19285099, PMID:20338993 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
decreases activity
ISO
EXP
Minocycline results in decreased expression of MMP2 protein
Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP2 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP2 protein]
Minocycline results in decreased activity of MMP2 protein
CTD PMID:11835378, PMID:14508231, PMID:16846501, PMID:19285099, PMID:24292262 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP3 mRNA] CTD PMID:19285099 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases activity
decreases expression
ISO
EXP
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 protein]; Minocycline inhibits the reaction [FMR1 gene mutant form results in increased expression of and results in increased activity of MMP9 protein]
Minocycline results in decreased activity of MMP9 protein
Minocycline results in decreased expression of MMP9 protein
CTD PMID:16846501, PMID:18835858, PMID:19285099 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Minocycline affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:72,771,992...72,789,861
Ensembl chr13:72,771,984...72,789,841
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]
Minocycline inhibits the reaction [lead acetate results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [manganese chloride results in increased expression of NOS2 protein]
CTD PMID:15485488, PMID:18836210, PMID:19285099, PMID:22952811 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ocln occludin increases expression EXP minocycline increases expression of occludin protein in left corpus callosum of rats with right carotid artery occlusion RGD PMID:29486300 RGD:27095946 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in decreased expression of PAFAH1B2 protein] CTD PMID:21561882 NCBI chr 8:50,256,969...50,310,043
Ensembl chr 8:50,259,248...50,277,797
JBrowse link
G Prdx2 peroxiredoxin 2 multiple interactions ISO Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRDX2 protein] CTD PMID:23562983 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO Minocycline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PRDX3 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein] CTD PMID:23562983 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Minocycline inhibits the reaction [PRKN gene mutant form results in increased susceptibility to Rotenone] CTD PMID:16573651 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Prtn3 proteinase 3 increases expression ISO Minocycline results in increased expression of PRTN3 protein CTD PMID:12900849 NCBI chr 7:12,643,712...12,646,951
Ensembl chr 7:12,643,516...12,646,960
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP Minocycline inhibits the reaction [Morphine results in increased expression of PTGS1 mRNA] CTD PMID:18706994 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects expression ISO Minocycline affects the expression of RELA protein CTD PMID:17898303 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 affects expression ISO Minocycline affects the expression of HLA-F mRNA CTD PMID:25811541 NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Minocycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Minocycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 mRNA] CTD PMID:24292262 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Minocycline inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein] CTD PMID:16839653 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions EXP Minocycline inhibits the reaction [cypermethrin results in decreased expression of SNAP25 protein] CTD PMID:21561882 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein] CTD PMID:23562983 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stmn1 stathmin 1 multiple interactions EXP
ISO
Minocycline inhibits the reaction [cypermethrin results in decreased expression of STMN1 protein]
Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein]
CTD PMID:21561882, PMID:23562983 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
EXP Minocycline results in increased expression of TGFB1 mRNA
Minocycline inhibits the reaction [Toluene results in decreased expression of TGFB1 mRNA]
CTD PMID:32234516 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2 protein] results in increased expression of BCL2 mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of BCL2 protein; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP protein CTD PMID:20606027 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
Minocycline inhibits the reaction [lead acetate results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [manganese chloride results in increased expression of TNF protein]
Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; Minocycline inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; Minocycline inhibits the reaction [lead acetate results in increased secretion of TNF protein]; Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]
Minocycline results in decreased expression of TNF mRNA
CTD PMID:14588118, PMID:15485488, PMID:18836210, PMID:19285099, PMID:21719015, PMID:22952811, PMID:24530660 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Minocycline results in decreased expression of TP53 protein CTD PMID:15172883 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpo thyroid peroxidase decreases activity EXP Minocycline results in decreased activity of TPO protein CTD PMID:26884060 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link
G Tuba1a tubulin, alpha 1A multiple interactions ISO Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein] CTD PMID:23562983 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Minocycline results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfc vascular endothelial growth factor C multiple interactions ISO Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of VEGFC mRNA] CTD PMID:24292262 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
G Vegfd vascular endothelial growth factor D multiple interactions ISO Minocycline inhibits the reaction [Oxygen deficiency results in increased expression of VEGFD mRNA] CTD PMID:24292262 NCBI chr  X:31,816,480...31,852,239
Ensembl chr  X:31,816,436...31,851,715
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor multiple interactions ISO [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]; [[Minocycline promotes the reaction [HIF1A protein binds to VHL protein]] co-treated with [Minocycline results in increased expression of EGLN1 protein]] results in increased degradation of HIF1A protein; Minocycline promotes the reaction [HIF1A protein binds to VHL protein] CTD PMID:24292262 NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP Minocycline inhibits the reaction [Paraquat results in increased expression of XBP1 protein] CTD PMID:22245251 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression
multiple interactions
EXP
ISO
Minocycline results in increased expression of XIAP protein
[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of XIAP protein
CTD PMID:14998631, PMID:20606027 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          tetracenomycin 91
            8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)tetracenomycin C 0
            8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C 0
            8-demethyl-8-(alpha-L-rhamnosyl)tetracenomycin C 0
            8-demethyltetracenomycin C 0
            aklaviketone 0
            elloramycin A 0
            epsilon-rhodomycinone 0
            minocycline + 91
            premithramycin A2' 0
            premithramycin A3' 0
            tetracenomycin A2 0
            tetracenomycin B1 0
            tetracenomycin B2 0
            tetracenomycin B3 0
            tetracenomycin C + 0
            tetracenomycin D1 0
            tetracenomycin D3 + 0
            tetracenomycin E 0
            tetracenomycin F1 + 0
            tetracenomycin F2 0
            tetracenomycin M 0
            tetracenomycin X 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            heteroorganic entity 19184
                              organochalcogen compound 18894
                                organooxygen compound 18816
                                  polyketide 8621
                                    tetracenomycin 91
                                      8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)tetracenomycin C 0
                                      8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C 0
                                      8-demethyl-8-(alpha-L-rhamnosyl)tetracenomycin C 0
                                      8-demethyltetracenomycin C 0
                                      aklaviketone 0
                                      elloramycin A 0
                                      epsilon-rhodomycinone 0
                                      minocycline + 91
                                      premithramycin A2' 0
                                      premithramycin A3' 0
                                      tetracenomycin A2 0
                                      tetracenomycin B1 0
                                      tetracenomycin B2 0
                                      tetracenomycin B3 0
                                      tetracenomycin C + 0
                                      tetracenomycin D1 0
                                      tetracenomycin D3 + 0
                                      tetracenomycin E 0
                                      tetracenomycin F1 + 0
                                      tetracenomycin F2 0
                                      tetracenomycin M 0
                                      tetracenomycin X 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.