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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nonanedioic acid
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Accession:CHEBI:48131 term browser browse the term
Definition:An alpha,omega-dicarboxylic acid that is heptane substituted at positions 1 and 7 by carboxy groups.
Synonyms:related_synonym: 1,7-Heptanedicarboxylic acid;   1,7-dicarboxyheptane;   1,9-nonanedioic acid;   Azelainsaeure;   Azelex;   Finacea;   Formula=C9H16O4;   InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13);   InChIKey=BDJRBEYXGGNYIS-UHFFFAOYSA-N;   Nonandisaeure;   SMILES=OC(=O)CCCCCCCC(O)=O;   Skinoren;   acide azelaique;   acidum azelaicum;   anchoic acid;   azelaic acid;   lepargylic acid;   n-nonanedioic acid
 alt_id: CHEBI:2949;   CHEBI:40912
 xref: Beilstein:1101094;   CAS:123-99-9;   DrugBank:DB00548;   Drug_Central:270;   Gmelin:261342;   HMDB:HMDB0000784;   KEGG:C08261;   KEGG:D03034;   LIPID_MAPS_instance:LMFA01170054
 xref_mesh: MESH:C010038
 xref: MetaCyc:CPD0-1265;   PDBeChem:AZ1;   PMID:22770225;   PMID:24280644;   PMID:28600633;   Reaxys:1101094;   Wikipedia:Azelaic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:132955;   is_conjugate_acid_of CHEBI:78208


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nonanedioic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd68 Cd68 molecule decreases expression ISO azelaic acid results in decreased expression of CD68 mRNA CTD PMID:19880116 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Dct dopachrome tautomerase decreases expression
multiple interactions
ISO azelaic acid results in decreased expression of DCT protein
[Taurine co-treated with azelaic acid] results in decreased expression of DCT protein
CTD PMID:20804622 NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494
JBrowse link
G Gna15 G protein subunit alpha 15 increases response to substance
multiple interactions
ISO GNA15 protein results in increased susceptibility to azelaic acid
[GNA15 protein results in increased susceptibility to azelaic acid] which results in increased activity of OLFR544 protein
CTD PMID:15598656 NCBI chr 7:11,054,249...11,075,152
Ensembl chr 7:11,054,333...11,077,251
JBrowse link
G Gnal G protein subunit alpha L increases response to substance
multiple interactions
ISO GNAL protein results in increased susceptibility to azelaic acid
[GNAL protein results in increased susceptibility to azelaic acid] which results in increased activity of OLFR544 protein; Egtazic Acid inhibits the reaction [[GNAL protein results in increased susceptibility to azelaic acid] which results in increased activity of OLFR544 protein]; Egtazic Acid inhibits the reaction [GNAL protein results in increased susceptibility to azelaic acid]
CTD PMID:15598656 NCBI chr18:62,805,406...62,946,133
Ensembl chr18:62,805,410...62,944,630
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 decreases expression ISO azelaic acid results in decreased expression of IGFBP3 protein CTD PMID:19880116 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Taurine co-treated with azelaic acid] results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:20804622 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Taurine co-treated with azelaic acid] results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:20804622 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression
multiple interactions
ISO azelaic acid results in decreased expression of MITF protein
[Taurine co-treated with azelaic acid] results in decreased expression of MITF protein
CTD PMID:20804622 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Plat plasminogen activator, tissue type decreases expression
multiple interactions
ISO azelaic acid results in decreased expression of PLAT mRNA
azelaic acid results in decreased expression of and results in decreased secretion of PLAT protein
CTD PMID:8635147 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
decreases expression
ISO azelaic acid results in decreased expression of and results in decreased secretion of PLAU protein
azelaic acid results in decreased expression of PLAU mRNA
CTD PMID:8635147 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
increases expression
ISO azelaic acid results in increased activity of PPARG protein
azelaic acid results in increased expression of PPARG mRNA
CTD PMID:20545756 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
increases expression
ISO azelaic acid results in increased expression of and results in increased secretion of SERPINE1 protein
azelaic acid results in increased expression of SERPINE1 mRNA
CTD PMID:8635147 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Tyr tyrosinase decreases expression
multiple interactions
ISO azelaic acid results in decreased expression of TYR protein
[Taurine co-treated with azelaic acid] results in decreased activity of TYR protein; [Taurine co-treated with azelaic acid] results in decreased expression of TYR protein
CTD PMID:20804622 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression
multiple interactions
ISO azelaic acid results in decreased expression of TYRP1 protein
[Taurine co-treated with azelaic acid] results in decreased expression of TYRP1 protein
CTD PMID:20804622 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          antibacterial agent 13021
            nonanedioic acid 14
              1-O-hexadecyl-2-(8-carboxyoctanoyl)-sn-glycero-3-phosphocholine 0
              1-azelaoyl-sn-glycero-3-phosphocholine 0
              1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine 0
              2-azelaoyl-sn-glycero-3-phosphocholine 0
              nonanedioic acid monoglycoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      dicarboxylic acids and O-substituted derivatives 10272
                                        dicarboxylic acid 10265
                                          alpha,omega-dicarboxylic acid 2774
                                            nonanedioic acid 14
                                              1-O-hexadecyl-2-(8-carboxyoctanoyl)-sn-glycero-3-phosphocholine 0
                                              1-azelaoyl-sn-glycero-3-phosphocholine 0
                                              1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine 0
                                              2-azelaoyl-sn-glycero-3-phosphocholine 0
                                              nonanedioic acid monoglycoside 0
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