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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzoisochromanequinone
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Accession:CHEBI:48129 term browser browse the term
Definition:A class of Streptomyces aromatic polyketide antibiotics.
Synonyms:related_synonym: benzoisochromanequinones


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frenolicin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO frenolicin B binds to and results in decreased activity of AKT1 protein CTD PMID:19309081 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions		 ISO frenolicin B results in decreased phosphorylation of EIF4EBP1 protein
Acetylcysteine inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]; GLRX3 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]; PRDX1 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein]		 CTD PMID:30661989 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Glrx3 glutaredoxin 3 multiple interactions ISO [frenolicin B results in decreased activity of GLRX3 protein] which results in decreased abundance of Glutathione; [frenolicin B results in decreased activity of GLRX3 protein] which results in increased abundance of Hydrogen Peroxide; [frenolicin B results in decreased activity of GLRX3 protein] which results in increased abundance of Reactive Oxygen Species; frenolicin B binds to and results in decreased activity of GLRX3 protein; GLRX3 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:30661989 NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO Acetylcysteine inhibits the reaction [frenolicin B results in increased cleavage of PARP1 protein] CTD PMID:30661989 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO [frenolicin B results in decreased activity of PRDX1 protein] which results in decreased abundance of Glutathione; [frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Hydrogen Peroxide; [frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Reactive Oxygen Species; Acetylcysteine inhibits the reaction [[frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Reactive Oxygen Species]; frenolicin B binds to and results in decreased activity of PRDX1 protein; PRDX1 protein inhibits the reaction [frenolicin B results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:30661989 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO frenolicin B results in decreased phosphorylation of RPS6KB1 protein CTD PMID:30661989 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
Kalafungin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO kalafungin binds to and results in decreased activity of AKT1 protein CTD PMID:19309081 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
Medermycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO medermycin binds to and results in decreased activity of AKT1 protein CTD PMID:19309081 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      biological role 19902
        antimicrobial agent 18269
          heterocyclic antibiotic 3023
            organooxygen heterocyclic antibiotic 103
              benzoisochromanequinone 6
                (2S,10R,3'S,4'S,6'S)-4'-deacetyl-griseusin B 0
                (2S,10R,3'S,4'S,6'S)-4'-deacetyl-griseusin B methyl ester 0
                (2S,9S,10S,3'S,4'S,6'S)-4'-deacetyl-griseusin A 0
                (2S,9S,10S,3'S,4'S,6'S)-griseusin E 0
                1-Hydroxydehydroherbarin 0
                1R, 4′R, 5′R-ulosporin G 0
                1R, 4′S, 5′R -ulosporin G 0
                1R-ulosporin A 0
                1S-ulosporin A 0
                3′-N-methyl-medermycin 0
                4'-dehydro-deacetylgriseusin A 0
                7-desmethylherbarin 0
                8-O-methyl-fusarubin 0
                8-hydroxyherbarin 0
                9-O-methylfusarubin 0
                9-desmethylherbarine 0
                Anhydrofusarubin lactol 0
                Arizonin A1 0
                Arizonin B1 0
                Ascomycone A 0
                Ascomycone B 0
                Astropaquinone B 0
                Astropaquinone C 0
                Biatriosporin K 0
                Dehydroherbarin 0
                Delitzchianone A 0
                Dihydrokalafungin 0
                Eleutherin 0
                Ent-astropaquinone C 0
                Epi-deacetylgriseusin A 0
                Epi-deacetylgriseusin B 0
                Griseusin A 0
                Griseusin D 0
                Herbarin 0
                Kalafungin 1
                Medermycin 1
                Menoxymycin A 0
                Menoxymycin B 0
                Nanaomycin 0
                Nanaomycin C 0
                OM-173alphaA 0
                OM-173betaA 0
                Sch 38519 0
                Thysanone 0
                actinorhodin 0
                auricin 0
                frenolicin B 6
                granaticin 0
                griseusin B 0
                methyl 2-[(1R,3R,4R)-4,9-dihydroxy-5,10-dioxo-1-propyl-3,4-dihydro-1H-benzo[g]isochromen-3-yl]acetate 0
                nanaomycin A 0
                protoaphin aglucone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            heteroorganic entity 19559
                              organochalcogen compound 19317
                                organooxygen compound 19231
                                  carbonyl compound 18945
                                    ketone 17194
                                      cyclic ketone 15710
                                        quinone 8651
                                          benzoisochromanequinone 6
                                            (2S,10R,3'S,4'S,6'S)-4'-deacetyl-griseusin B 0
                                            (2S,10R,3'S,4'S,6'S)-4'-deacetyl-griseusin B methyl ester 0
                                            (2S,9S,10S,3'S,4'S,6'S)-4'-deacetyl-griseusin A 0
                                            (2S,9S,10S,3'S,4'S,6'S)-griseusin E 0
                                            1-Hydroxydehydroherbarin 0
                                            1R, 4′R, 5′R-ulosporin G 0
                                            1R, 4′S, 5′R -ulosporin G 0
                                            1R-ulosporin A 0
                                            1S-ulosporin A 0
                                            3′-N-methyl-medermycin 0
                                            4'-dehydro-deacetylgriseusin A 0
                                            7-desmethylherbarin 0
                                            8-O-methyl-fusarubin 0
                                            8-hydroxyherbarin 0
                                            9-O-methylfusarubin 0
                                            9-desmethylherbarine 0
                                            Anhydrofusarubin lactol 0
                                            Arizonin A1 0
                                            Arizonin B1 0
                                            Ascomycone A 0
                                            Ascomycone B 0
                                            Astropaquinone B 0
                                            Astropaquinone C 0
                                            Biatriosporin K 0
                                            Dehydroherbarin 0
                                            Delitzchianone A 0
                                            Dihydrokalafungin 0
                                            Eleutherin 0
                                            Ent-astropaquinone C 0
                                            Epi-deacetylgriseusin A 0
                                            Epi-deacetylgriseusin B 0
                                            Griseusin A 0
                                            Griseusin D 0
                                            Herbarin 0
                                            Kalafungin 1
                                            Medermycin 1
                                            Menoxymycin A 0
                                            Menoxymycin B 0
                                            Nanaomycin 0
                                            Nanaomycin C 0
                                            OM-173alphaA 0
                                            OM-173betaA 0
                                            Sch 38519 0
                                            Thysanone 0
                                            actinorhodin 0
                                            auricin 0
                                            frenolicin B 6
                                            granaticin 0
                                            griseusin B 0
                                            methyl 2-[(1R,3R,4R)-4,9-dihydroxy-5,10-dioxo-1-propyl-3,4-dihydro-1H-benzo[g]isochromen-3-yl]acetate 0
                                            nanaomycin A 0
                                            protoaphin aglucone 0
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