|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] |
CTD |
PMID:16757516 |
|
NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
|
|
G |
Adam9 |
ADAM metallopeptidase domain 9 |
multiple interactions |
ISO |
ebselen inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein] |
CTD |
PMID:17018608 |
|
NCBI chr16:71,810,377...71,887,926
Ensembl chr16:71,810,377...71,887,926
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|
G |
Afp |
alpha-fetoprotein |
multiple interactions |
EXP |
ebselen inhibits the reaction [Aflatoxin B1 results in increased expression of AFP mRNA] |
CTD |
PMID:11133813 |
|
NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
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|
G |
Alad |
aminolevulinate dehydratase |
multiple interactions decreases activity |
EXP ISO |
Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein] ebselen inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein] |
CTD |
PMID:14630126 PMID:17624921 PMID:23933410 |
|
NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
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|
G |
Alox5 |
arachidonate 5-lipoxygenase |
decreases activity |
ISO |
ebselen results in decreased activity of ALOX5 protein |
CTD |
PMID:7590103 |
|
NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
ebselen inhibits the reaction [sodium arsenite results in increased expression of BAX protein] |
CTD |
PMID:30558456 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP |
ebselen inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein] |
CTD |
PMID:30558456 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO EXP |
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP3 protein] ebselen results in increased activity of CASP3 protein ebselen inhibits the reaction [Methylmercury Compounds results in increased activity of CASP3 protein]; ebselen inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein] |
CTD |
PMID:21300091 PMID:23649643 PMID:25068500 PMID:30558456 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO EXP |
ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP9 protein] ebselen inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein] |
CTD |
PMID:18629305 PMID:23649643 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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|
G |
Cat |
catalase |
increases activity multiple interactions |
EXP |
ebselen results in increased activity of CAT protein ebselen inhibits the reaction [sodium arsenite results in decreased activity of CAT protein] |
CTD |
PMID:27282967 PMID:30558456 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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|
G |
Cox4i1 |
cytochrome c oxidase subunit 4i1 |
increases expression |
ISO |
ebselen results in increased expression of COX4I1 protein |
CTD |
PMID:27385396 |
|
NCBI chr19:54,245,958...54,252,198
Ensembl chr19:54,245,950...54,252,225
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|
G |
Cs |
citrate synthase |
multiple interactions |
ISO |
ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein] |
CTD |
PMID:27385396 |
|
NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA] |
CTD |
PMID:11903743 |
|
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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|
G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
increases phosphorylation |
EXP |
ebselen results in increased phosphorylation of EIF2S1 protein |
CTD |
PMID:27282967 |
|
NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
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|
G |
Ephx2 |
epoxide hydrolase 2 |
multiple interactions |
ISO |
ebselen binds to and results in decreased activity of EPHX2 protein |
CTD |
PMID:23219563 |
|
NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
|
|
G |
Fmr1 |
FMRP translational regulator 1 |
multiple interactions |
ISO |
ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein] |
CTD |
PMID:27385396 |
|
NCBI chr X:154,684,924...154,722,369
Ensembl chr X:154,684,935...154,722,314
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein] |
CTD |
PMID:14572605 |
|
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
|
|
G |
Gck |
glucokinase |
multiple interactions |
ISO |
[ebselen co-treated with Glucose] results in increased activity of GCK protein |
CTD |
PMID:23795780 |
|
NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
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|
G |
Gfap |
glial fibrillary acidic protein |
increases phosphorylation |
EXP |
ebselen results in increased phosphorylation of GFAP protein |
CTD |
PMID:27282967 |
|
NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
|
|
G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions |
EXP |
ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]; ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 protein] |
CTD |
PMID:12958040 |
|
NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
|
|
G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
ISO |
ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]] ebselen inhibits the reaction [Methylmercury Compounds results in decreased activity of GPX1 protein] |
CTD |
PMID:23795780 PMID:28383113 |
|
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
|
|
G |
Gsr |
glutathione-disulfide reductase |
increases activity multiple interactions |
EXP |
ebselen results in increased activity of GSR protein ebselen inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] |
CTD |
PMID:27282967 PMID:30558456 |
|
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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|
G |
Gsta1 |
glutathione S-transferase alpha 1 |
multiple interactions |
EXP |
ebselen binds to and results in decreased activity of [GSTA1 protein binds to GSTA3 protein] |
CTD |
PMID:8147899 |
|
NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
|
|
G |
Gsta3 |
glutathione S-transferase alpha 3 |
multiple interactions |
EXP |
ebselen binds to and results in decreased activity of [GSTA1 protein binds to GSTA3 protein]; ebselen binds to and results in decreased activity of GSTA3 protein |
CTD |
PMID:8147899 |
|
NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
|
|
G |
Gstm1 |
glutathione S-transferase mu 1 |
multiple interactions |
EXP |
ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein] |
CTD |
PMID:8147899 |
|
NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
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|
G |
Gstm2 |
glutathione S-transferase mu 2 |
multiple interactions |
EXP |
ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein] |
CTD |
PMID:8147899 |
|
NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
EXP |
ebselen binds to and results in decreased activity of GSTP1 protein |
CTD |
PMID:8147899 |
|
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]] |
CTD |
PMID:19374849 |
|
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
[ebselen affects the abundance of Reactive Oxygen Species] which results in decreased expression of HMOX1 protein; [ebselen affects the abundance of Reactive Oxygen Species] which results in increased activity of HMOX1 protein |
CTD |
PMID:16959961 |
|
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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|
G |
Hpgds |
hematopoietic prostaglandin D synthase |
increases expression |
ISO |
ebselen results in increased expression of HPGDS mRNA |
CTD |
PMID:21669866 |
|
NCBI chr 4:95,945,356...95,970,666
Ensembl chr 4:95,946,025...95,970,666
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|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] |
CTD |
PMID:12794164 |
|
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
ebselen inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] |
CTD |
PMID:30558456 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases activity increases phosphorylation |
ISO EXP |
ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] ebselen results in increased activity of MAPK1 protein ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK1 protein] ebselen analog results in increased phosphorylation of MAPK1 protein; ebselen results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases activity increases phosphorylation |
ISO EXP |
ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] ebselen results in increased activity of MAPK3 protein ebselen analog results in increased phosphorylation of MAPK3 protein; ebselen results in increased phosphorylation of MAPK3 protein ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK3 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases phosphorylation |
EXP |
ebselen results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:27282967 |
|
NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
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|
G |
Mmp13 |
matrix metallopeptidase 13 |
multiple interactions |
EXP |
ebselen inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA] |
CTD |
PMID:11903743 |
|
NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
|
|
G |
Ngf |
nerve growth factor |
multiple interactions |
ISO |
ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:20495008 |
|
NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
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|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases activity |
ISO EXP |
ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] ebselen results in decreased activity of NOS2 protein |
CTD |
PMID:7590103 PMID:12794164 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
decreases activity |
EXP |
ebselen results in decreased activity of NQO1 protein |
CTD |
PMID:7590103 |
|
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
|
|
G |
Pdx1 |
pancreatic and duodenal homeobox 1 |
multiple interactions |
ISO |
[ebselen co-treated with Glucose] results in increased expression of PDX1 protein |
CTD |
PMID:23795780 |
|
NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
|
|
G |
Phospho1 |
phosphoethanolamine/phosphocholine phosphatase 1 |
decreases activity |
ISO |
ebselen results in decreased activity of PHOSPHO1 protein |
CTD |
PMID:17227223 |
|
NCBI chr10:83,635,557...83,643,862
Ensembl chr10:83,636,518...83,643,859
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein] |
CTD |
PMID:14572605 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
|
|
G |
Slc11a2 |
solute carrier family 11 member 2 |
multiple interactions |
ISO |
ebselen inhibits the reaction [SLC11A2 protein results in increased uptake of Iron] |
CTD |
PMID:16984886 |
|
NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
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|
G |
Slc2a2 |
solute carrier family 2 member 2 |
multiple interactions |
ISO |
[ebselen co-treated with Glucose] results in increased expression of SLC2A2 protein |
CTD |
PMID:23795780 |
|
NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
|
|
G |
Smad3 |
SMAD family member 3 |
multiple interactions |
ISO |
ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:21131394 |
|
NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
|
|
G |
Sod1 |
superoxide dismutase 1 |
decreases response to substance multiple interactions |
ISO |
ebselen results in decreased susceptibility to SOD1 protein mutant form ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]] |
CTD |
PMID:16702190 PMID:23795780 |
|
NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
|
|
G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:20495008 |
|
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP ISO |
ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA] ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] |
CTD |
PMID:11903743 PMID:16757516 PMID:21131394 |
|
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
|
|
G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
EXP |
ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] |
CTD |
PMID:11903743 |
|
NCBI chr X:1,364,771...1,369,451
Ensembl chr X:1,364,786...1,369,384
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|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
ebselen inhibits the reaction [sodium arsenite results in increased expression of TNF protein] |
CTD |
PMID:30558456 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
|
|
G |
Txnrd1 |
thioredoxin reductase 1 |
multiple interactions |
ISO |
ebselen results in increased expression of and results in increased activity of TXNRD1 protein |
CTD |
PMID:28383113 |
|
NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
|
|
G |
Ucp2 |
uncoupling protein 2 |
multiple interactions |
ISO |
[ebselen co-treated with Glucose] results in decreased expression of UCP2 protein |
CTD |
PMID:23795780 |
|
NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
|
|
G |
Xbp1 |
X-box binding protein 1 |
increases phosphorylation |
EXP |
ebselen results in increased phosphorylation of XBP1 protein |
CTD |
PMID:27282967 |
|
NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
|
|
G |
Xpa |
XPA, DNA damage recognition and repair factor |
multiple interactions |
ISO |
ebselen inhibits the reaction [Zinc binds to XPA protein] |
CTD |
PMID:15265038 |
|
NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928
|
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