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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:vinorelbine
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Accession:CHEBI:480999 term browser browse the term
Definition:A vinca alkaloid with a norvinblastine skeleton.
Synonyms:exact_synonym: methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-acetoxy-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
 related_synonym: Formula=C45H54N4O8;   InChI=1S/C45H54N4O8/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3/t28-,37-,38+,39+,42+,43+,44-,45+/m0/s1;   InChIKey=GBABOYUKABKIAF-IELIFDKJSA-N;   Nor-5'-anhydrovinblastine;   SMILES=CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC;   vinorelbina;   vinorelbinum
 xref: Beilstein:9035861;   CAS:71486-22-1;   DrugBank:DB00361;   Drug_Central:2827;   KEGG:D08680
 xref_mesh: MESH:C030852
 xref: Patent:JP8031096;   Patent:US4307100


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vinorelbine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [pifithrin co-treated with vinorelbine] results in increased cleavage of and results in increased activity of CASP3 protein
[Cisplatin co-treated with vinorelbine] results in increased activity of CASP3 protein
CTD PMID:18516295, PMID:21544650 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of CASP7 mRNA CTD PMID:21544650 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cd40lg CD40 ligand multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of CD40LG mRNA CTD PMID:21544650 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO vinorelbine results in decreased expression of CDKN2A protein CTD PMID:17904787 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions
increases expression
ISO [vinorelbine co-treated with Cisplatin] results in increased expression of EPCAM protein
vinorelbine results in increased expression of EPCAM protein
CTD PMID:12695858 NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in increased expression of FAS protein CTD PMID:21544650 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of FASL mRNA CTD PMID:21544650 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of IL10 mRNA CTD PMID:21544650 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il7 interleukin 7 multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in increased expression of IL7 protein CTD PMID:21544650 NCBI chr 2:96,427,884...96,474,979
Ensembl chr 2:96,439,286...96,474,977
JBrowse link
G Krt18 keratin 18 increases expression
increases metabolic processing
ISO vinorelbine results in increased expression of KRT18 protein
vinorelbine results in increased metabolism of KRT18 protein
CTD PMID:16685278 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Lhx4 LIM homeobox 4 multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of LHX4 mRNA CTD PMID:21544650 NCBI chr13:73,348,874...73,400,416
Ensembl chr13:73,348,842...73,400,416
JBrowse link
G Npm1 nucleophosmin 1 decreases response to substance ISO NPM1 protein results in decreased susceptibility to vinorelbine CTD PMID:24736981 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO vinorelbine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Pak5 p21 (RAC1) activated kinase 5 multiple interactions ISO [Cisplatin co-treated with Vinorelbine] results in decreased expression of PAK5 mRNA CTD PMID:21544650 NCBI chr 3:129,042,232...129,357,512
Ensembl chr 3:129,042,742...129,357,491
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa decreases expression ISO vinorelbine results in decreased expression of PROC protein CTD PMID:10475134 NCBI chr18:24,918,402...24,928,822
Ensembl chr18:24,918,398...24,929,091
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO vinorelbine results in decreased expression of PTGS2 protein CTD PMID:17904787 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rbm17 RNA binding motif protein 17 decreases response to substance ISO RBM17 protein results in decreased susceptibility to vinorelbine CTD PMID:16061639 NCBI chr17:70,586,345...70,603,289
Ensembl chr17:70,586,394...70,603,267
JBrowse link
G Slc29a1 solute carrier family 29 member 1 affects response to substance ISO SLC29A1 protein affects the susceptibility to vinorelbine CTD PMID:18452103 NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO Vinorelbine results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of TNF mRNA CTD PMID:21544650 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of TRAF1 mRNA CTD PMID:21544650 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        fuel 10797
          methanol 3062
            methyl ester 3051
              vinorelbine 21
                vinflunine 0
                vinorelbine D-tartrate 0
                vinorelbine L-tartrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        monocarboxylic acid 17406
                                          acetic acid 10697
                                            acetate ester 3452
                                              vinorelbine 21
                                                vinflunine 0
                                                vinorelbine D-tartrate 0
                                                vinorelbine L-tartrate 0
paths to the root

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