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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:vinorelbine
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Accession:CHEBI:480999 term browser browse the term
Definition:A vinca alkaloid with a norvinblastine skeleton.
Synonyms:exact_synonym: methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-acetoxy-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
 related_synonym: Formula=C45H54N4O8;   InChI=1S/C45H54N4O8/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3/t28-,37-,38+,39+,42+,43+,44-,45-/m0/s1;   InChIKey=GBABOYUKABKIAF-IELIFDKJSA-N;   Nor-5'-anhydrovinblastine;   SMILES=CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC;   vinorelbina;   vinorelbinum
 xref: Beilstein:9035861;   CAS:71486-22-1;   DrugBank:DB00361;   Drug_Central:2827;   KEGG:D08680
 xref_mesh: MESH:C030852
 xref: Patent:JP8031096;   Patent:US4307100


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vinorelbine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [pifithrin co-treated with vinorelbine] results in increased cleavage of and results in increased activity of CASP3 protein
[Cisplatin co-treated with vinorelbine] results in increased activity of CASP3 protein		 CTD PMID:18516295 PMID:21544650 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of CASP7 mRNA CTD PMID:21544650 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cd40lg CD40 ligand multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of CD40LG mRNA CTD PMID:21544650 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO vinorelbine results in decreased expression of CDKN2A protein CTD PMID:17904787 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions
increases expression		 ISO [vinorelbine co-treated with Cisplatin] results in increased expression of EPCAM protein
vinorelbine results in increased expression of EPCAM protein		 CTD PMID:12695858 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in increased expression of FAS protein CTD PMID:21544650 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of FASL mRNA CTD PMID:21544650 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of IL10 mRNA CTD PMID:21544650 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il7 interleukin 7 multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in increased expression of IL7 protein CTD PMID:21544650 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075 		JBrowse link
G Krt18 keratin 18 increases expression
increases metabolic processing		 ISO vinorelbine results in increased expression of KRT18 protein
vinorelbine results in increased metabolism of KRT18 protein		 CTD PMID:16685278 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Lhx4 LIM homeobox 4 multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of LHX4 mRNA CTD PMID:21544650 NCBI chr13:67,877,109...67,917,219
Ensembl chr13:67,877,109...67,927,003 		JBrowse link
G Npm1 nucleophosmin 1 decreases response to substance ISO NPM1 protein results in decreased susceptibility to vinorelbine CTD PMID:24736981 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO vinorelbine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pak5 p21 (RAC1) activated kinase 5 multiple interactions ISO [Cisplatin co-treated with Vinorelbine] results in decreased expression of PAK5 mRNA CTD PMID:21544650 NCBI chr 3:123,395,678...123,703,967
Ensembl chr 3:123,396,497...123,703,930 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa decreases expression ISO vinorelbine results in decreased expression of PROC protein CTD PMID:10475134 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO vinorelbine results in decreased expression of PTGS2 protein CTD PMID:17904787 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rbm17 RNA binding motif protein 17 decreases response to substance ISO RBM17 protein results in decreased susceptibility to vinorelbine CTD PMID:16061639 NCBI chr17:66,937,140...66,954,034
Ensembl chr17:66,937,140...66,954,014 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 affects response to substance ISO SLC29A1 protein affects the susceptibility to vinorelbine CTD PMID:18452103 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO Vinorelbine results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of TNF mRNA CTD PMID:21544650 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of TRAF1 mRNA CTD PMID:21544650 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        fuel 11368
          methanol 3969
            methyl ester 3915
              vinorelbine 21
                vinflunine 0
                vinorelbine D-tartrate 0
                vinorelbine L-tartrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbon oxoacid 18681
                                    carboxylic acid 18678
                                      monocarboxylic acid 18024
                                        acetic acid 11092
                                          acetate ester 4057
                                            vinorelbine 21
                                              vinflunine 0
                                              vinorelbine D-tartrate 0
                                              vinorelbine L-tartrate 0
paths to the root