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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:vinorelbine
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Accession:CHEBI:480999 term browser browse the term
Definition:A vinca alkaloid with a norvinblastine skeleton.
Synonyms:exact_synonym: methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-acetoxy-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
 related_synonym: Formula=C45H54N4O8;   InChI=1S/C45H54N4O8/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3/t28-,37-,38+,39+,42+,43+,44-,45+/m0/s1;   InChIKey=GBABOYUKABKIAF-IELIFDKJSA-N;   Nor-5'-anhydrovinblastine;   SMILES=CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC;   vinorelbina;   vinorelbinum
 xref: Beilstein:9035861;   CAS:71486-22-1;   DrugBank:DB00361;   Drug_Central:2827;   KEGG:D08680
 xref_mesh: MESH:C030852
 xref: Patent:JP8031096;   Patent:US4307100


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vinorelbine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [pifithrin co-treated with vinorelbine] results in increased cleavage of and results in increased activity of CASP3 protein
[Cisplatin co-treated with vinorelbine] results in increased activity of CASP3 protein
CTD PMID:18516295 PMID:21544650 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of CASP7 mRNA CTD PMID:21544650 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Cd40lg CD40 ligand multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of CD40LG mRNA CTD PMID:21544650 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO vinorelbine results in decreased expression of CDKN2A protein CTD PMID:17904787 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions
increases expression
ISO [vinorelbine co-treated with Cisplatin] results in increased expression of EPCAM protein
vinorelbine results in increased expression of EPCAM protein
CTD PMID:12695858 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in increased expression of FAS protein CTD PMID:21544650 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of FASL mRNA CTD PMID:21544650 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of IL10 mRNA CTD PMID:21544650 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il7 interleukin 7 multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in increased expression of IL7 protein CTD PMID:21544650 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Krt18 keratin 18 increases expression
increases metabolic processing
ISO vinorelbine results in increased expression of KRT18 protein
vinorelbine results in increased metabolism of KRT18 protein
CTD PMID:16685278 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Lhx4 LIM homeobox 4 multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of LHX4 mRNA CTD PMID:21544650 NCBI chr13:67,873,618...67,927,003
Ensembl chr13:67,877,109...67,927,003
JBrowse link
G Npm1 nucleophosmin 1 decreases response to substance ISO NPM1 protein results in decreased susceptibility to vinorelbine CTD PMID:24736981 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO vinorelbine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Pak5 p21 (RAC1) activated kinase 5 multiple interactions ISO [Cisplatin co-treated with Vinorelbine] results in decreased expression of PAK5 mRNA CTD PMID:21544650 NCBI chr 3:123,395,678...123,703,967
Ensembl chr 3:123,396,497...123,703,930
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa decreases expression ISO vinorelbine results in decreased expression of PROC protein CTD PMID:10475134 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO vinorelbine results in decreased expression of PTGS2 protein CTD PMID:17904787 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rbm17 RNA binding motif protein 17 decreases response to substance ISO RBM17 protein results in decreased susceptibility to vinorelbine CTD PMID:16061639 NCBI chr17:66,937,140...66,954,034
Ensembl chr17:66,937,140...66,954,014
JBrowse link
G Slc29a1 solute carrier family 29 member 1 affects response to substance ISO SLC29A1 protein affects the susceptibility to vinorelbine CTD PMID:18452103 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO Vinorelbine results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of TNF mRNA CTD PMID:21544650 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions ISO [Cisplatin co-treated with vinorelbine] results in decreased expression of TRAF1 mRNA CTD PMID:21544650 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        fuel 11017
          methanol 3858
            methyl ester 3830
              vinorelbine 21
                vinflunine 0
                vinorelbine D-tartrate 0
                vinorelbine L-tartrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          acetic acid 10854
                                            acetate ester 3875
                                              vinorelbine 21
                                                vinflunine 0
                                                vinorelbine D-tartrate 0
                                                vinorelbine L-tartrate 0
paths to the root