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G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
Brefeldin A inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:15525798 |
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NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation |
EXP |
Brefeldin A inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein] Brefeldin A results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:15525798 PMID:24090963 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Atf4 |
activating transcription factor 4 |
increases expression |
ISO |
Brefeldin A results in increased expression of ATF4 protein |
CTD |
PMID:24865413 PMID:27358234 |
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NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions |
ISO |
Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of ATF6 protein] |
CTD |
PMID:20493918 |
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NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
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G |
Atp7a |
ATPase copper transporting alpha |
multiple interactions |
ISO |
Brefeldin A inhibits the reaction [ATP7A protein affects the localization of Doxorubicin] |
CTD |
PMID:17510416 |
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NCBI chr X:77,076,085...77,193,644
Ensembl chr X:77,076,106...77,193,644
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G |
Atp7b |
ATPase copper transporting beta |
multiple interactions |
ISO |
Brefeldin A inhibits the reaction [Copper affects the localization of ATP7B protein] |
CTD |
PMID:10982773 |
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NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286
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G |
Casp12 |
caspase 12 |
increases activity multiple interactions |
ISO |
Brefeldin A results in increased activity of CASP12 protein Apigenin inhibits the reaction [Brefeldin A results in increased activity of CASP12 protein] |
CTD |
PMID:20493918 |
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NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
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G |
Casp2 |
caspase 2 |
multiple interactions |
ISO |
Bortezomib promotes the reaction [Brefeldin A results in increased cleavage of and results in increased activity of CASP2 protein]; Brefeldin A promotes the reaction [Bortezomib results in increased cleavage of and results in increased activity of CASP2 protein]; Brefeldin A results in increased cleavage of and results in increased activity of CASP2 protein |
CTD |
PMID:18723477 |
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NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
Brefeldin A results in increased activity of CASP3 protein Apigenin inhibits the reaction [Brefeldin A results in increased activity of CASP3 protein] |
CTD |
PMID:20150630 PMID:20493918 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Cftr |
CF transmembrane conductance regulator |
decreases activity multiple interactions |
ISO |
Brefeldin A results in decreased activity of CFTR protein Brefeldin A inhibits the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium results in increased activity of CFTR protein mutant form]; Brefeldin A inhibits the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Brefeldin A inhibits the reaction [miglustat results in increased activity of CFTR protein mutant form] |
CTD |
PMID:15371258 PMID:18230692 |
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NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions |
ISO |
Brefeldin A inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Brefeldin A inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] |
CTD |
PMID:18346843 |
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NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
Brefeldin A inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:22167199 |
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NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions |
ISO |
Brefeldin A results in increased expression of DDIT3 mRNA; Brefeldin A results in increased expression of DDIT3 protein Acetylcysteine inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Apigenin inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein] |
CTD |
PMID:19428936 PMID:20493918 PMID:20626587 PMID:24865413 PMID:27358234 |
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NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
increases expression |
ISO |
Brefeldin A results in increased expression of EIF2AK3 protein |
CTD |
PMID:24865413 |
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NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions increases phosphorylation |
ISO |
Apigenin inhibits the reaction [Brefeldin A results in increased phosphorylation of ERN1 protein] |
CTD |
PMID:20493918 |
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NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
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G |
Fhl1 |
four and a half LIM domains 1 |
multiple interactions |
EXP |
Brefeldin A inhibits the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA] |
CTD |
PMID:17161435 |
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NCBI chr X:159,112,516...159,172,528
Ensembl chr X:159,112,880...159,172,524
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G |
Hsp90b1 |
heat shock protein 90 beta family member 1 |
multiple interactions increases expression |
ISO |
Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSP90B1 protein] |
CTD |
PMID:20493918 |
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NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Glutathione inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein] Brefeldin A results in increased expression of HSPA5 mRNA; Brefeldin A results in increased expression of HSPA5 protein bortezomib inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein] |
CTD |
PMID:12147617 PMID:18723477 PMID:19428936 PMID:20493918 PMID:20626587 PMID:27358234 |
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NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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G |
Il6 |
interleukin 6 |
decreases secretion multiple interactions |
ISO |
Brefeldin A results in decreased secretion of IL6 protein Brefeldin A inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] |
CTD |
PMID:11216681 PMID:22102721 PMID:24849676 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation multiple interactions |
EXP |
Brefeldin A results in decreased phosphorylation of MAPK1 protein Brefeldin A inhibits the reaction [Levodopa results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24090963 PMID:25044243 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation multiple interactions |
EXP |
Brefeldin A results in decreased phosphorylation of MAPK3 protein Brefeldin A inhibits the reaction [Levodopa results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24090963 PMID:25044243 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Nfe2l1 |
nuclear factor, erythroid 2-like 1 |
multiple interactions |
ISO |
Brefeldin A affects the reaction [sodium arsenite affects the localization of NFE2L1 protein] |
CTD |
PMID:20805060 |
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NCBI chr10:84,686,762...84,699,313
Ensembl chr10:84,682,460...84,698,886
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
multiple interactions |
ISO |
Brefeldin A inhibits the reaction [sodium arsenite results in increased activity of NFE2L2 protein] |
CTD |
PMID:20805060 |
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NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
decreases expression |
ISO |
Brefeldin A results in decreased expression of NR1I2 mRNA |
CTD |
PMID:25616597 |
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NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of PARP1 protein] |
CTD |
PMID:20493918 |
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NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Scnn1b |
sodium channel epithelial 1 subunit beta |
multiple interactions |
EXP |
Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1B protein]] |
CTD |
PMID:12608646 |
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NCBI chr 1:191,829,547...191,883,991
Ensembl chr 1:191,829,555...191,884,298
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G |
Scnn1g |
sodium channel epithelial 1 subunit gamma |
multiple interactions |
EXP |
Brefeldin A inhibits the reaction [Terbutaline inhibits the reaction [Oxygen deficiency results in decreased expression of SCNN1G protein]] |
CTD |
PMID:12608646 |
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NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
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G |
Tnf |
tumor necrosis factor |
decreases secretion |
ISO |
Brefeldin A results in decreased secretion of TNF protein |
CTD |
PMID:22102721 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tnfrsf10b |
TNF receptor superfamily member 10b |
multiple interactions |
ISO |
Brefeldin A inhibits the reaction [Bortezomib results in increased localization of TNFRSF10A protein] |
CTD |
PMID:17326159 |
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NCBI chr15:51,433,853...51,464,215
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
Brefeldin A affects the reaction [Bortezomib results in increased susceptibility to and results in increased activity of TNFSF10 protein] |
CTD |
PMID:17326159 |
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NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
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G |
Tp53bp1 |
tumor protein p53 binding protein 1 |
increases expression |
ISO |
Brefeldin A results in increased expression of TP53BP1 protein |
CTD |
PMID:27358234 |
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NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790
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G |
Vegfa |
vascular endothelial growth factor A |
decreases secretion multiple interactions increases expression |
ISO |
Brefeldin A results in decreased secretion of VEGFA protein Brefeldin A inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein] Brefeldin A results in increased expression of VEGFA mRNA |
CTD |
PMID:12147617 PMID:20850416 |
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NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Xbp1 |
X-box binding protein 1 |
multiple interactions increases expression increases activity |
ISO |
bortezomib inhibits the reaction [Brefeldin A results in increased activity of XBP1 protein] Brefeldin A results in increased expression of XBP1 protein |
CTD |
PMID:18723477 PMID:27358234 |
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NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
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