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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:HC toxin
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Accession:CHEBI:48028 term browser browse the term
Definition:A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues.
Synonyms:related_synonym: Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine);   Cyclo(aoe-pro-ala-ala);   Formula=C21H32N4O6;   InChI=1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)/t12-,13+,14-,15+,17?/m0/s1;   InChIKey=GNYCTMYOHGBSBI-KVUCBBCISA-N;   SMILES=[H][C@]12CCCN1C(=O)[C@H](CCCCCC(=O)C1CO1)NC(=O)[C@@H](C)NC(=O)[C@H](C)NC2=O
 xref: Beilstein:4729824;   CAS:83209-65-8;   KEGG:C15676
 xref_mesh: MESH:C037654
 xref: PMID:10671527;   PMID:12297630;   PMID:15283467;   PMID:16839576;   PMID:18074352;   PMID:18230731;   PMID:18262346;   PMID:19737099;   PMID:3918884;   PMID:9917303;   Patent:EP2194061;   Reaxys:4729824


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HC toxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gldc glycine decarboxylase increases expression ISO HC toxin results in increased expression of GLDC mRNA CTD PMID:33770205 NCBI chr 1:248,295,140...248,377,122
Ensembl chr 1:248,297,331...248,377,093
JBrowse link
G Gpr183 G protein-coupled receptor 183 decreases expression ISO HC toxin results in decreased expression of GPR183 mRNA CTD PMID:33770205 NCBI chr15:108,364,701...108,376,221
Ensembl chr15:108,364,701...108,376,221
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO HC toxin results in increased expression of IDI1 mRNA CTD PMID:33770205 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Klhl42 kelch-like family, member 42 decreases expression ISO HC toxin results in decreased expression of KLHL42 mRNA CTD PMID:33770205 NCBI chr 4:181,481,147...181,502,916
Ensembl chr 4:181,481,147...181,502,916
JBrowse link
G Mepce methylphosphate capping enzyme decreases expression ISO HC toxin results in decreased expression of MEPCE mRNA CTD PMID:33770205 NCBI chr12:21,721,246...21,725,965
Ensembl chr12:21,721,837...21,725,435
Ensembl chr12:21,721,837...21,725,435
JBrowse link
G Nrros negative regulator of reactive oxygen species decreases expression ISO HC toxin results in decreased expression of NRROS mRNA CTD PMID:33770205 NCBI chr11:71,872,728...71,889,897
Ensembl chr11:71,872,830...71,889,887
JBrowse link
G Ppil1 peptidylprolyl isomerase like 1 decreases expression ISO HC toxin results in decreased expression of PPIL1 mRNA CTD PMID:33770205 NCBI chr20:6,515,638...6,864,571
Ensembl chr20:6,515,638...6,864,571
JBrowse link
G Srgap3 SLIT-ROBO Rho GTPase activating protein 3 increases expression ISO HC toxin results in increased expression of SRGAP3 mRNA CTD PMID:33770205 NCBI chr 4:144,638,782...144,869,961
Ensembl chr 4:144,638,335...144,869,919
JBrowse link
G Tmcc2 transmembrane and coiled-coil domain family 2 increases expression ISO HC toxin results in increased expression of TMCC2 mRNA CTD PMID:33770205 NCBI chr13:49,132,685...49,169,771
Ensembl chr13:49,132,667...49,169,918
JBrowse link
G Tubb2a tubulin, beta 2A class IIa increases expression ISO HC toxin results in increased expression of TUBB2A mRNA CTD PMID:33770205 NCBI chr17:31,493,145...31,496,827
Ensembl chr17:31,493,107...31,498,651
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase increases expression ISO HC toxin results in increased expression of YES1 mRNA CTD PMID:33770205 NCBI chr 9:121,802,471...121,918,906
Ensembl chr 9:121,802,673...121,902,678
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      biological role 19732
        biochemical role 19333
          metabolite 19312
            HC toxin 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon atom 19586
                          organic molecular entity 19586
                            organic group 18631
                              organic divalent group 18622
                                organodiyl group 18622
                                  carbonyl group 18537
                                    carbonyl compound 18537
                                      carboxylic acid 18215
                                        carboacyl group 17441
                                          univalent carboacyl group 17441
                                            carbamoyl group 17248
                                              carboxamide 17248
                                                peptide 9456
                                                  cyclic peptide 8778
                                                    homodetic cyclic peptide 8370
                                                      HC toxin 11
paths to the root