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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:HC toxin
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Accession:CHEBI:48028 term browser browse the term
Definition:A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues.
Synonyms:related_synonym: Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine);   Cyclo(aoe-pro-ala-ala);   Formula=C21H32N4O6;   InChI=1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)/t12-,13+,14-,15+,17?/m0/s1;   InChIKey=GNYCTMYOHGBSBI-KVUCBBCISA-N;   SMILES=[H][C@]12CCCN1C(=O)[C@H](CCCCCC(=O)C1CO1)NC(=O)[C@@H](C)NC(=O)[C@H](C)NC2=O
 xref: Beilstein:4729824;   CAS:83209-65-8;   KEGG:C15676
 xref_mesh: MESH:C037654
 xref: PMID:10671527;   PMID:12297630;   PMID:15283467;   PMID:16839576;   PMID:18074352;   PMID:18230731;   PMID:18262346;   PMID:19737099;   PMID:3918884;   PMID:9917303;   Patent:EP2194061;   Reaxys:4729824



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HC toxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gldc glycine decarboxylase increases expression ISO HC toxin results in increased expression of GLDC mRNA CTD PMID:33770205 NCBI chr 1:227,883,247...227,962,119
Ensembl chr 1:227,883,249...227,962,097
JBrowse link
G Gpr183 G protein-coupled receptor 183 decreases expression ISO HC toxin results in decreased expression of GPR183 mRNA CTD PMID:33770205 NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO HC toxin results in increased expression of IDI1 mRNA CTD PMID:33770205 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Klhl42 kelch-like family, member 42 decreases expression ISO HC toxin results in decreased expression of KLHL42 mRNA CTD PMID:33770205 NCBI chr 4:179,999,655...180,027,283
Ensembl chr 4:180,004,580...180,027,283
JBrowse link
G Mepce methylphosphate capping enzyme decreases expression ISO HC toxin results in decreased expression of MEPCE mRNA CTD PMID:33770205 NCBI chr12:18,911,796...18,916,515
Ensembl chr12:18,911,796...18,916,514
JBrowse link
G Nrros negative regulator of reactive oxygen species decreases expression ISO HC toxin results in decreased expression of NRROS mRNA CTD PMID:33770205 NCBI chr11:68,628,641...68,646,152
Ensembl chr11:68,628,712...68,646,142
JBrowse link
G Ppil1 peptidylprolyl isomerase like 1 decreases expression ISO HC toxin results in decreased expression of PPIL1 mRNA CTD PMID:33770205 NCBI chr20:7,302,292...7,322,349
Ensembl chr20:7,302,621...7,322,354
JBrowse link
G Srgap3 SLIT-ROBO Rho GTPase activating protein 3 increases expression ISO HC toxin results in increased expression of SRGAP3 mRNA CTD PMID:33770205 NCBI chr 4:145,839,369...146,070,556
Ensembl chr 4:145,840,078...146,070,575
JBrowse link
G Tmcc2 transmembrane and coiled-coil domain family 2 increases expression ISO HC toxin results in increased expression of TMCC2 mRNA CTD PMID:33770205 NCBI chr13:43,794,029...43,831,716
Ensembl chr13:43,794,029...43,831,716
JBrowse link
G Tubb2a tubulin, beta 2A class IIa increases expression ISO HC toxin results in increased expression of TUBB2A mRNA CTD PMID:33770205 NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase increases expression ISO HC toxin results in increased expression of YES1 mRNA CTD PMID:33770205 NCBI chr 9:113,200,256...113,275,942
Ensembl chr 9:113,200,256...113,299,837
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          metabolite 19631
            HC toxin 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        carboacyl group 17730
                                          univalent carboacyl group 17710
                                            carbamoyl group 17550
                                              carboxamide 17570
                                                peptide 9504
                                                  cyclic peptide 8818
                                                    homodetic cyclic peptide 8385
                                                      HC toxin 11
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