CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: HC toxin
Accession: CHEBI:48028
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Definition: A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues.
Synonyms: related_synonym: Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine); Cyclo(aoe-pro-ala-ala); Formula=C21H32N4O6; InChI=1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)/t12-,13+,14-,15+,17?/m0/s1; InChIKey=GNYCTMYOHGBSBI-KVUCBBCISA-N; SMILES=[H][C@]12CCCN1C(=O)[C@H](CCCCCC(=O)C1CO1)NC(=O)[C@@H](C)NC(=O)[C@H](C)NC2=O
xref: CAS:83209-65-8; KEGG:C15676
xref_mesh: MESH:C037654
xref: PMID:10671527; PMID:12297630; PMID:15283467; PMID:16839576; PMID:18074352; PMID:18230731; PMID:18262346; PMID:19737099; PMID:3918884; PMID:9917303; Patent:EP2194061; Reaxys:4729824
G
Gldc
glycine decarboxylase
increases expression
ISO
HC toxin results in increased expression of GLDC mRNA
CTD
PMID:33770205
NCBI chr 1:227,883,249...227,962,119
Ensembl chr 1:227,883,249...227,962,097
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Gpr183
G protein-coupled receptor 183
decreases expression
ISO
HC toxin results in decreased expression of GPR183 mRNA
CTD
PMID:33770205
NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559
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Idi1
isopentenyl-diphosphate delta isomerase 1
increases expression
ISO
HC toxin results in increased expression of IDI1 mRNA
CTD
PMID:33770205
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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Klhl42
kelch-like family, member 42
decreases expression
ISO
HC toxin results in decreased expression of KLHL42 mRNA
CTD
PMID:33770205
NCBI chr 4:181,730,343...181,760,899
Ensembl chr 4:180,004,580...180,027,283
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Mepce
methylphosphate capping enzyme
decreases expression
ISO
HC toxin results in decreased expression of MEPCE mRNA
CTD
PMID:33770205
NCBI chr12:18,911,796...18,916,515
Ensembl chr12:18,911,796...18,916,514
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Nrros
negative regulator of reactive oxygen species
decreases expression
ISO
HC toxin results in decreased expression of NRROS mRNA
CTD
PMID:33770205
NCBI chr11:68,628,641...68,646,152
Ensembl chr11:68,628,712...68,646,142
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Ppil1
peptidylprolyl isomerase like 1
decreases expression
ISO
HC toxin results in decreased expression of PPIL1 mRNA
CTD
PMID:33770205
NCBI chr20:7,302,292...7,322,349
Ensembl chr20:7,302,621...7,322,354
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Srgap3
SLIT-ROBO Rho GTPase activating protein 3
increases expression
ISO
HC toxin results in increased expression of SRGAP3 mRNA
CTD
PMID:33770205
NCBI chr 4:145,839,369...146,070,556
Ensembl chr 4:145,840,078...146,070,575
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Tmcc2
transmembrane and coiled-coil domain family 2
increases expression
ISO
HC toxin results in increased expression of TMCC2 mRNA
CTD
PMID:33770205
NCBI chr13:43,794,029...43,831,716
Ensembl chr13:43,794,029...43,831,716
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Tubb2a
tubulin, beta 2A class IIa
increases expression
ISO
HC toxin results in increased expression of TUBB2A mRNA
CTD
PMID:33770205
NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714
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Yes1
YES proto-oncogene 1, Src family tyrosine kinase
increases expression
ISO
HC toxin results in increased expression of YES1 mRNA
CTD
PMID:33770205
NCBI chr 9:113,200,256...113,275,942
Ensembl chr 9:113,200,256...113,299,837
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