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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:21871475 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:21871475 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions |
EXP |
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein] |
CTD |
PMID:21871475 |
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NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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G |
Pdgfrb |
platelet derived growth factor receptor beta |
multiple interactions |
EXP |
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein] |
CTD |
PMID:21871475 |
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NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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G |
Plcg1 |
phospholipase C, gamma 1 |
multiple interactions |
EXP |
ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein] |
CTD |
PMID:21871475 |
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NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
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G |
Sphk1 |
sphingosine kinase 1 |
decreases expression decreases activity |
ISO |
ampelopsin results in decreased expression of SPHK1 protein ampelopsin results in decreased activity of SPHK1 protein |
CTD |
PMID:22251058 |
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NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
taxifolin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] |
CTD |
PMID:34217736 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions decreases activity |
ISO |
taxifolin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione] taxifolin results in decreased activity of ABCC1 protein |
CTD |
PMID:15041478 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Rotenone results in decreased activity of ACHE protein] |
CTD |
PMID:35187747 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Adipor2 |
adiponectin receptor 2 |
multiple interactions |
ISO |
taxifolin binds to and results in increased activity of ADIPOR2 protein |
CTD |
PMID:23691032 |
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NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
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G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
taxifolin binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
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NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Agt |
angiotensinogen |
decreases expression |
ISO |
taxifolin results in decreased expression of AGT protein modified form |
CTD |
PMID:24269735 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA]; AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA] |
CTD |
PMID:29584932 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein]; taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]] |
CTD |
PMID:32828744 PMID:35465754 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Apoa1 |
apolipoprotein A1 |
increases expression |
ISO |
taxifolin results in increased expression of APOA1 protein |
CTD |
PMID:11108730 |
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NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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G |
Apob |
apolipoprotein B |
decreases secretion decreases expression |
ISO |
taxifolin results in decreased secretion of APOB protein taxifolin results in decreased expression of APOB protein |
CTD |
PMID:11108730 PMID:15380446 |
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NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of BAX protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of BAX protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of BAX protein]] |
CTD |
PMID:35465754 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of BCL2 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]] |
CTD |
PMID:32525071 PMID:35465754 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Becn1 |
beclin 1 |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]] |
CTD |
PMID:35465754 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Casp3 |
caspase 3 |
decreases activity multiple interactions |
EXP |
taxifolin results in decreased activity of CASP3 protein Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein]; taxifolin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]] |
CTD |
PMID:24269735 PMID:32828744 PMID:35465754 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
decreases activity |
EXP |
taxifolin results in decreased activity of CASP9 protein |
CTD |
PMID:24269735 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]]; taxifolin analog inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; taxifolin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CAT mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT mRNA]; taxifolin inhibits the reaction [Rotenone results in decreased activity of CAT protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]] |
CTD |
PMID:30372826 PMID:32525071 PMID:33741339 PMID:35187747 PMID:35465754 PMID:36198370 More...
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccna1 |
cyclin A1 |
decreases expression |
ISO |
taxifolin results in decreased expression of CCNA1 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
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G |
Cdc25a |
cell division cycle 25A |
decreases expression |
ISO |
taxifolin results in decreased expression of CDC25A mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions |
EXP |
taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA] |
CTD |
PMID:30372826 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Cycs |
cytochrome c, somatic |
affects localization |
EXP |
taxifolin affects the localization of CYCS protein |
CTD |
PMID:24269735 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CYP11A1 protein] |
CTD |
PMID:32525071 PMID:36198370 |
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NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression multiple interactions |
ISO |
taxifolin results in increased expression of CYP1A1 mRNA; taxifolin results in increased expression of CYP1A1 protein AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:22422552 PMID:29584932 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases expression |
ISO |
taxifolin results in decreased expression of CYP2E1 mRNA |
CTD |
PMID:17541156 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Dcc |
DCC netrin 1 receptor |
increases expression |
ISO |
taxifolin results in increased expression of DCC mRNA |
CTD |
PMID:17541156 |
|
NCBI chr18:64,868,987...65,972,783
Ensembl chr18:64,873,898...65,972,740
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G |
Egf |
epidermal growth factor |
decreases expression |
ISO |
taxifolin results in decreased expression of EGF mRNA |
CTD |
PMID:17541156 |
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NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Fgf18 |
fibroblast growth factor 18 |
decreases expression |
ISO |
taxifolin results in decreased expression of FGF18 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818
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G |
Fgf3 |
fibroblast growth factor 3 |
decreases expression |
ISO |
taxifolin results in decreased expression of FGF3 mRNA |
CTD |
PMID:17541156 |
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NCBI chr 1:200,001,162...200,005,539
Ensembl chr 1:200,001,261...200,005,187
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein] |
CTD |
PMID:32828744 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]] |
CTD |
PMID:35465754 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]] |
CTD |
PMID:35465754 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gas6 |
growth arrest specific 6 |
increases expression |
ISO |
taxifolin results in increased expression of GAS6 mRNA |
CTD |
PMID:17541156 |
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NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
taxifolin results in increased expression of GDF15 mRNA |
CTD |
PMID:17541156 |
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NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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G |
Glul |
glutamate-ammonia ligase |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Rotenone results in decreased activity of GLUL protein] |
CTD |
PMID:35187747 |
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NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein] |
CTD |
PMID:32828744 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 protein] |
CTD |
PMID:32525071 |
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NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]] |
CTD |
PMID:35465754 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
ISO |
taxifolin results in increased expression of GSTM1 mRNA |
CTD |
PMID:17541156 |
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NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions decreases expression |
ISO EXP |
taxifolin results in increased expression of HMOX1 protein Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]] Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of HMOX1 protein] |
CTD |
PMID:16799064 PMID:31152760 PMID:35465754 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hsd17b1 |
hydroxysteroid (17-beta) dehydrogenase 1 |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]] |
CTD |
PMID:35465754 |
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NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
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G |
Hsd17b3 |
hydroxysteroid (17-beta) dehydrogenase 3 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD17B3 protein] |
CTD |
PMID:32525071 PMID:36198370 |
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NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]] |
CTD |
PMID:35465754 PMID:36198370 |
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NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein] |
CTD |
PMID:12044887 PMID:19103272 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein] taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of IFNG protein] |
CTD |
PMID:12044887 PMID:19103272 PMID:31152760 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ikbkg |
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Rotenone results in increased expression of IKBKG mRNA] |
CTD |
PMID:35187747 |
|
NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
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G |
Il18 |
interleukin 18 |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]] |
CTD |
PMID:35465754 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL1B protein]; taxifolin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA] |
CTD |
PMID:32828744 PMID:35187747 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein] |
CTD |
PMID:32828744 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Insl3 |
insulin-like 3 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSL3 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSL3 protein] |
CTD |
PMID:32525071 PMID:36198370 |
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NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
taxifolin results in decreased expression of JUN mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]] |
CTD |
PMID:35465754 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:12044887 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]] |
CTD |
PMID:35465754 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; taxifolin inhibits the reaction [Rotenone results in increased activity of MPO protein] |
CTD |
PMID:33741339 PMID:35187747 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]]; taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]] |
CTD |
PMID:35465754 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Mttp |
microsomal triglyceride transfer protein |
decreases activity |
ISO |
taxifolin results in decreased activity of MTTP protein |
CTD |
PMID:15380446 |
|
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression multiple interactions decreases expression |
ISO EXP |
taxifolin results in increased expression of NFE2L2 protein Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]] taxifolin results in decreased expression of NFE2L2 protein Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of NFE2L2 protein] |
CTD |
PMID:16799064 PMID:31152760 PMID:35465754 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Rotenone results in increased expression of NFKB1 mRNA] |
CTD |
PMID:35187747 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]] |
CTD |
PMID:35465754 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases activity increases expression |
ISO |
taxifolin results in increased activity of NQO1 protein taxifolin results in increased expression of NQO1 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
[taxifolin co-treated with [Iron-Dextran Complex results in increased abundance of Iron]] results in increased expression of PCNA protein |
CTD |
PMID:32828744 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pdgfb |
platelet derived growth factor subunit B |
decreases expression |
ISO |
taxifolin results in decreased expression of PDGFB mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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G |
Pik3ca |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
multiple interactions |
EXP |
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of PIK3CA protein] |
CTD |
PMID:32828744 |
|
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
increases phosphorylation |
ISO |
taxifolin results in increased phosphorylation of PPARA protein |
CTD |
PMID:23691032 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of PPARGC1A protein] |
CTD |
PMID:32525071 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
decreases phosphorylation |
ISO |
taxifolin results in decreased phosphorylation of PRKAA1 protein |
CTD |
PMID:23691032 |
|
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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G |
Prkaa2 |
protein kinase AMP-activated catalytic subunit alpha 2 |
decreases phosphorylation |
ISO |
taxifolin results in decreased phosphorylation of PRKAA2 protein |
CTD |
PMID:23691032 |
|
NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
taxifolin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] |
CTD |
PMID:21341175 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rasa1 |
RAS p21 protein activator 1 |
decreases expression |
ISO |
taxifolin results in decreased expression of RASA1 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854
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G |
Scarb1 |
scavenger receptor class B, member 1 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SCARB1 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SCARB1 protein] |
CTD |
PMID:36198370 |
|
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
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G |
Sirt1 |
sirtuin 1 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SIRT1 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein] |
CTD |
PMID:32525071 PMID:36198370 |
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NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 protein] |
CTD |
PMID:32525071 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD2 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA] |
CTD |
PMID:32525071 PMID:36198370 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sox9 |
SRY-box transcription factor 9 |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOX9 mRNA] |
CTD |
PMID:32525071 |
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NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein] |
CTD |
PMID:12044887 |
|
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]] |
CTD |
PMID:35465754 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Th |
tyrosine hydroxylase |
multiple interactions |
EXP |
taxifolin inhibits the reaction [Rotenone results in decreased activity of TH protein] |
CTD |
PMID:35187747 |
|
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein] taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein] |
CTD |
PMID:31152760 PMID:32828744 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Traf3 |
Tnf receptor-associated factor 3 |
increases expression |
ISO |
taxifolin results in increased expression of TRAF3 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481
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G |
Txnrd1 |
thioredoxin reductase 1 |
increases expression decreases activity |
ISO EXP |
taxifolin results in increased expression of TXNRD1 mRNA taxifolin results in decreased activity of TXNRD1 protein modified form |
CTD |
PMID:16618767 PMID:17541156 |
|
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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G |
Ucp1 |
uncoupling protein 1 |
multiple interactions |
EXP |
taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA] |
CTD |
PMID:30372826 |
|
NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression multiple interactions |
ISO |
taxifolin results in increased expression of UGT1A1 mRNA AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA] |
CTD |
PMID:29584932 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
ISO EXP |
taxifolin inhibits the reaction [XDH protein results in increased chemical synthesis of Superoxides] taxifolin inhibits the reaction [Rotenone results in increased activity of XDH protein] |
CTD |
PMID:19555678 PMID:35187747 |
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NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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G |
Xpa |
XPA, DNA damage recognition and repair factor |
increases expression |
ISO |
taxifolin results in increased expression of XPA mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726
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G |
Xrcc4 |
X-ray repair cross complementing 4 |
increases expression |
ISO |
taxifolin results in increased expression of XRCC4 mRNA |
CTD |
PMID:17541156 |
|
NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808
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G |
Afp |
alpha-fetoprotein |
affects binding |
EXP |
3-hydroxyflavanone binds to AFP protein |
CTD |
PMID:23013281 PMID:25349334 |
|
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Shbg |
sex hormone binding globulin |
affects binding |
ISO |
3-hydroxyflavanone binds to SHBG protein |
CTD |
PMID:25349334 |
|
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
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G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
multiple interactions |
ISO |
[astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA |
CTD |
PMID:29471006 |
|
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:29471006 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein] |
CTD |
PMID:29471006 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] |
CTD |
PMID:29471006 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] |
CTD |
PMID:29471006 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein] |
CTD |
PMID:29471006 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein] |
CTD |
PMID:29471006 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] |
CTD |
PMID:29471006 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions |
ISO |
astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA] |
CTD |
PMID:29471006 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein] |
CTD |
PMID:29471006 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein] |
CTD |
PMID:29471006 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:29471006 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:29471006 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein] astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein] |
CTD |
PMID:29471006 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:29471006 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] |
CTD |
PMID:29471006 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA] |
CTD |
PMID:29471006 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] |
CTD |
PMID:29471006 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein] |
CTD |
PMID:29471006 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein] |
CTD |
PMID:29471006 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA] astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein] |
CTD |
PMID:29471006 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein] |
CTD |
PMID:29471006 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
eriocitrin results in increased expression of BAX protein |
CTD |
PMID:34724282 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
eriocitrin results in decreased expression of BCL2 protein |
CTD |
PMID:34724282 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp7 |
caspase 7 |
increases expression |
ISO |
eriocitrin results in increased expression of CASP7 protein |
CTD |
PMID:34724282 |
|
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp9 |
caspase 9 |
increases expression |
ISO |
eriocitrin results in increased expression of CASP9 protein |
CTD |
PMID:34724282 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
eriocitrin results in decreased expression of CCND1 protein |
CTD |
PMID:34724282 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Jak2 |
Janus kinase 2 |
decreases phosphorylation |
ISO |
eriocitrin results in decreased phosphorylation of JAK2 protein |
CTD |
PMID:34724282 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions increases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [eriocitrin results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:34724282 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Pcna |
proliferating cell nuclear antigen |
decreases expression |
ISO |
eriocitrin results in decreased expression of PCNA protein |
CTD |
PMID:34724282 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
decreases phosphorylation |
ISO |
eriocitrin results in decreased phosphorylation of SRC protein |
CTD |
PMID:34724282 |
|
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G |
Stat3 |
signal transducer and activator of transcription 3 |
decreases phosphorylation |
ISO |
eriocitrin results in decreased phosphorylation of STAT3 protein |
CTD |
PMID:34724282 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
[ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]] |
CTD |
PMID:20438634 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity |
ISO |
eriodictyol results in decreased activity of ABCC1 protein |
CTD |
PMID:15670588 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Bcl2a1 |
BCL2-related protein A1 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
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G |
Cat |
catalase |
multiple interactions |
EXP |
eriodictyol inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein] |
CTD |
PMID:28978146 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA] |
CTD |
PMID:19426678 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G |
Cycs |
cytochrome c, somatic |
increases expression |
ISO |
eriodictyol results in increased expression of CYCS protein |
CTD |
PMID:37020356 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
eriodictyol inhibits the reaction [Arsenic Trioxide results in increased expression of GPT protein] |
CTD |
PMID:28978146 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx4 |
glutathione peroxidase 4 |
decreases expression |
ISO |
eriodictyol results in decreased expression of GPX4 protein |
CTD |
PMID:37020356 |
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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|
G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases activity |
ISO |
eriodictyol results in decreased activity of GSTP1 protein |
CTD |
PMID:15041478 |
|
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Hmox1 |
heme oxygenase 1 |
increases expression decreases expression multiple interactions |
ISO EXP |
eriodictyol results in increased expression of HMOX1 protein eriodictyol results in decreased expression of HMOX1 protein bardoxolone methyl inhibits the reaction [eriodictyol results in decreased expression of HMOX1 protein] eriodictyol results in increased expression of HMOX1 mRNA; eriodictyol results in increased expression of HMOX1 protein eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein] |
CTD |
PMID:16799064 PMID:28978146 PMID:37020356 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [IFNG protein results in increased abundance of Nitrites] |
CTD |
PMID:23942037 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] |
CTD |
PMID:21544733 PMID:31860763 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA] |
CTD |
PMID:20438634 PMID:21544733 PMID:31860763 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Irf3 |
interferon regulatory factor 3 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA] |
CTD |
PMID:19426678 |
|
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
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|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:21544733 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein] |
CTD |
PMID:31860763 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression decreases expression decreases phosphorylation multiple interactions |
ISO EXP |
eriodictyol results in increased expression of NFE2L2 protein eriodictyol results in decreased expression of NFE2L2 protein eriodictyol results in decreased phosphorylation of NFE2L2 protein bardoxolone methyl inhibits the reaction [eriodictyol results in decreased phosphorylation of NFE2L2 protein] eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein] eriodictyol results in increased expression of NFE2L2 mRNA; eriodictyol results in increased expression of NFE2L2 protein |
CTD |
PMID:16799064 PMID:28978146 PMID:37020356 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] |
CTD |
PMID:20438634 PMID:21544733 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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|
G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein] |
CTD |
PMID:31860763 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
decreases expression multiple interactions |
ISO |
eriodictyol results in decreased expression of NQO1 protein bardoxolone methyl inhibits the reaction [eriodictyol results in decreased expression of NQO1 protein] |
CTD |
PMID:37020356 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:31860763 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein] |
CTD |
PMID:20438634 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Slc7a11 |
solute carrier family 7 member 11 |
decreases expression |
ISO |
eriodictyol results in decreased expression of SLC7A11 protein |
CTD |
PMID:37020356 |
|
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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|
G |
Tbk1 |
TANK-binding kinase 1 |
decreases activity |
ISO |
eriodictyol results in decreased activity of TBK1 protein |
CTD |
PMID:19426678 |
|
NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases activity |
ISO |
eriodictyol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] eriodictyol results in decreased activity of TNF protein |
CTD |
PMID:11123379 PMID:20438634 PMID:21544733 PMID:31860763 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfaip3 |
TNF alpha induced protein 3 |
multiple interactions |
ISO |
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
[ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA] |
CTD |
PMID:20438634 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; hesperetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] |
CTD |
PMID:16156793 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]; hesperetin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]; hesperetin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] |
CTD |
PMID:16156793 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein] |
CTD |
PMID:16156793 |
|
NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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|
G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
[hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]] |
CTD |
PMID:27818223 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
decreases expression |
ISO |
hesperetin results in decreased expression of ADIPOQ mRNA |
CTD |
PMID:25345581 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Ager |
advanced glycosylation end product-specific receptor |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of AGER protein] |
CTD |
PMID:33522063 |
|
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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G |
Ahr |
aryl hydrocarbon receptor |
increases activity multiple interactions |
ISO |
hesperetin results in increased activity of AHR protein [2-hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR protein] |
CTD |
PMID:17869316 PMID:21720915 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
hesperetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:19222219 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alb |
albumin |
multiple interactions |
EXP |
hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of ALB protein] |
CTD |
PMID:34922902 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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|
G |
Aldh4a1 |
aldehyde dehydrogenase 4 family, member A1 |
affects binding |
ISO |
hesperetin binds to ALDH4A1 protein |
CTD |
PMID:37487865 |
|
NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345
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|
G |
Apex1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
affects binding |
ISO |
hesperetin binds to APEX1 protein |
CTD |
PMID:37487865 |
|
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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G |
Atg5 |
autophagy related 5 |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Doxorubicin results in decreased expression of ATG5 mRNA] |
CTD |
PMID:34933056 |
|
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Bax |
BCL2 associated X, apoptosis regulator |
affects expression multiple interactions increases expression |
ISO EXP |
hesperetin affects the expression of BAX protein [Cisplatin co-treated with hesperetin] results in decreased expression of BAX protein hesperetin promotes the reaction [Cisplatin results in increased expression of BAX protein] hesperetin analog results in increased expression of BAX protein; hesperetin results in increased expression of BAX mRNA; hesperetin results in increased expression of BAX protein hesperetin analog results in increased expression of BAX mRNA |
CTD |
PMID:15975156 PMID:20564462 PMID:22142698 PMID:25345581 PMID:31153982 PMID:37487865 More...
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|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
affects expression multiple interactions decreases expression |
ISO EXP |
hesperetin affects the expression of BCL2 protein hesperetin promotes the reaction [Cisplatin results in increased expression of BCL2 protein] hesperetin analog results in decreased expression of BCL2 protein; hesperetin results in decreased expression of BCL2 protein hesperetin analog results in decreased expression of BCL2 mRNA |
CTD |
PMID:15975156 PMID:20564462 PMID:22142698 PMID:31153982 PMID:37487865 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Becn1 |
beclin 1 |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Doxorubicin results in decreased expression of BECN1 mRNA] |
CTD |
PMID:34933056 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Casp3 |
caspase 3 |
affects cleavage increases cleavage multiple interactions increases expression increases activity |
ISO EXP |
hesperetin affects the cleavage of CASP3 protein hesperetin results in increased cleavage of CASP3 protein Acetylcysteine inhibits the reaction [hesperetin results in increased cleavage of CASP3 protein]; hesperetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] hesperetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein] hesperetin metabolite results in increased expression of CASP3 protein modified form; hesperetin results in increased expression of CASP3 protein modified form hesperetin analog results in increased activity of CASP3 protein hesperetin analog results in increased expression of CASP3 mRNA |
CTD |
PMID:15975156 PMID:19222219 PMID:20564462 PMID:22142698 PMID:31153982 PMID:37487865 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cat |
catalase |
increases activity multiple interactions decreases activity |
ISO EXP |
hesperetin results in increased activity of CAT protein hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein] hesperetin analog results in decreased activity of CAT protein; hesperetin results in decreased activity of CAT protein hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; hesperetin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein] |
CTD |
PMID:19023542 PMID:19222219 PMID:19497424 PMID:21134734 PMID:22142698 PMID:26546711 PMID:34922902 More...
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|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] |
CTD |
PMID:24707119 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein] |
CTD |
PMID:24707119 |
|
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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G |
Ccnd1 |
cyclin D1 |
decreases expression multiple interactions |
ISO EXP |
hesperetin results in decreased expression of CCND1 hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of CCND1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein] |
CTD |
PMID:17927510 PMID:27818223 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccs |
copper chaperone for superoxide dismutase |
affects binding |
ISO |
hesperetin binds to CCS protein |
CTD |
PMID:37487865 |
|
NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
hesperetin results in decreased expression of CDK2 |
CTD |
PMID:17927510 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
multiple interactions decreases expression |
ISO |
hesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein] hesperetin results in decreased expression of CDK4 |
CTD |
PMID:17927510 |
|
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
ISO |
hesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein] hesperetin results in increased expression of CDKN1A; hesperetin results in increased expression of CDKN1A mRNA |
CTD |
PMID:17927510 PMID:25345581 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
ISO |
hesperetin results in increased expression of CDKN1B |
CTD |
PMID:17927510 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression |
ISO |
hesperetin results in decreased expression of CEBPA protein |
CTD |
PMID:25345581 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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|
G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
EXP |
[hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] |
CTD |
PMID:27818223 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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|
G |
Csf3 |
colony stimulating factor 3 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 protein] |
CTD |
PMID:24707119 |
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NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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G |
Cyb5a |
cytochrome b5 type A |
multiple interactions |
EXP |
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYB5A protein] |
CTD |
PMID:19497424 |
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NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
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G |
Cycs |
cytochrome c, somatic |
increases expression |
ISO |
hesperetin analog results in increased expression of CYCS protein; hesperetin results in increased expression of CYCS protein |
CTD |
PMID:22142698 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
decreases activity |
ISO |
hesperetin results in decreased activity of CYP19A1 protein |
CTD |
PMID:10403137 |
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NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions decreases activity |
ISO |
[2-hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein] hesperetin results in decreased activity of CYP1A1 protein hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein] |
CTD |
PMID:10781868 PMID:21720915 PMID:26546711 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
hesperetin results in decreased activity of CYP1A2 protein |
CTD |
PMID:29753067 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
hesperetin results in decreased activity of CYP1B1 protein |
CTD |
PMID:10781868 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
ISO |
hesperetin results in decreased activity of CYP2C19 protein |
CTD |
PMID:29753067 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein] |
CTD |
PMID:19497424 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Dazl |
deleted in azoospermia-like |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Doxorubicin results in decreased expression of DAZL mRNA] |
CTD |
PMID:34933056 |
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NCBI chr 9:10,695,593...10,712,330
Ensembl chr 9:10,695,592...10,712,323
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions |
ISO |
hesperetin results in increased expression of DDIT3 protein Acetylcysteine inhibits the reaction [hesperetin results in increased expression of DDIT3 protein] |
CTD |
PMID:37487865 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Dnm1l |
dynamin 1-like |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Doxorubicin results in increased expression of DNM1L mRNA]; hesperetin inhibits the reaction [Doxorubicin results in increased expression of DNM1L protein] |
CTD |
PMID:34933056 |
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NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Fabp4 |
fatty acid binding protein 4 |
decreases expression |
ISO |
hesperetin results in decreased expression of FABP4 mRNA |
CTD |
PMID:25345581 |
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NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein] |
CTD |
PMID:21134734 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gpx4 |
glutathione peroxidase 4 |
affects binding |
ISO |
hesperetin binds to GPX4 protein |
CTD |
PMID:37487865 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
EXP |
hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of GSK3B protein] |
CTD |
PMID:34922902 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP ISO |
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of GSR protein]; hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein] hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein] |
CTD |
PMID:21134734 PMID:26546711 PMID:35567572 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO |
hesperetin results in increased expression of HMOX1 protein [Cisplatin co-treated with hesperetin] results in increased expression of HMOX1 protein hesperetin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; hesperetin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein] |
CTD |
PMID:15316927 PMID:31153982 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions |
ISO |
hesperetin results in increased expression of HSPA5 protein Acetylcysteine inhibits the reaction [hesperetin results in increased expression of HSPA5 protein] |
CTD |
PMID:37487865 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein] |
CTD |
PMID:33522063 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein] |
CTD |
PMID:24707119 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein] |
CTD |
PMID:24707119 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions affects expression |
ISO EXP |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]] hesperetin affects the expression of IL1B protein |
CTD |
PMID:24707119 PMID:24871567 PMID:28428136 PMID:32762101 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions affects expression |
ISO EXP |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of IL6 protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 protein]; hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein] hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]] hesperetin affects the expression of IL6 protein |
CTD |
PMID:24707119 PMID:24871567 PMID:28428136 PMID:32762101 PMID:33522063 PMID:34922902 PMID:35567572 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Jak1 |
Janus kinase 1 |
multiple interactions |
ISO |
hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK1 protein] |
CTD |
PMID:28428136 |
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NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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G |
Jak2 |
Janus kinase 2 |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of JAK2 protein] |
CTD |
PMID:33522063 |
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NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
affects binding |
ISO |
hesperetin binds to KEAP1 protein |
CTD |
PMID:37487865 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Lpl |
lipoprotein lipase |
decreases expression |
ISO |
hesperetin results in decreased expression of LPL mRNA |
CTD |
PMID:25345581 |
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NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:31153982 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:31153982 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP ISO |
hesperetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] [Cisplatin co-treated with hesperetin] results in decreased phosphorylation of MAPK8 protein hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:19222219 PMID:31153982 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mir150 |
microRNA 150 |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Doxorubicin results in decreased expression of MIR150 mRNA] |
CTD |
PMID:34933056 |
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NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108
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G |
Mir181b2 |
microRNA 181b-2 |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Doxorubicin results in decreased expression of MIR181B2 mRNA] |
CTD |
PMID:34933056 |
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NCBI chr 3:22,616,948...22,617,035
Ensembl chr 3:22,616,948...22,617,035
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G |
Mir410 |
microRNA 410 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of MIR410 mRNA]; MIR410 mRNA affects the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]] |
CTD |
PMID:32762101 |
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NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO EXP |
hesperetin inhibits the reaction [Cisplatin results in increased expression of MPO protein] hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] |
CTD |
PMID:31153982 PMID:33522063 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Doxorubicin results in increased expression of MTOR mRNA]; hesperetin inhibits the reaction [Doxorubicin results in increased expression of MTOR protein] |
CTD |
PMID:34933056 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
EXP |
hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of MYC protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of MYC protein] |
CTD |
PMID:27818223 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression |
ISO |
hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased expression of NFE2L2 protein]; hesperetin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein] [Cisplatin co-treated with hesperetin] results in increased expression of NFE2L2 protein hesperetin results in increased expression of NFE2L2 protein |
CTD |
PMID:26546711 PMID:31153982 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
Hemin promotes the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 protein] |
CTD |
PMID:12512693 PMID:15316927 PMID:35567572 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nox4 |
NADPH oxidase 4 |
decreases expression multiple interactions |
ISO |
hesperetin results in decreased expression of NOX4 protein hesperetin inhibits the reaction [Cisplatin results in increased expression of NOX4 protein] |
CTD |
PMID:31153982 |
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NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases expression |
EXP ISO |
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of NQO1 protein] hesperetin inhibits the reaction [Cisplatin results in decreased expression of NQO1 protein] [Cisplatin co-treated with hesperetin] results in increased expression of NQO1 protein hesperetin results in increased expression of NQO1 protein |
CTD |
PMID:19497424 PMID:31153982 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nqo2 |
N-ribosyldihydronicotinamide:quinone dehydrogenase 2 |
affects binding |
ISO |
hesperetin binds to NQO2 protein |
CTD |
PMID:37487865 |
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NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity |
ISO |
hesperetin results in increased activity of NR1I2 protein |
CTD |
PMID:25455453 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
ISO EXP |
hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of PCNA protein] hesperetin inhibits the reaction [Doxorubicin results in decreased expression of PCNA mRNA] |
CTD |
PMID:26546711 PMID:34933056 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pdcd6ip |
programmed cell death 6 interacting protein |
decreases expression multiple interactions |
ISO |
hesperetin results in decreased expression of PDCD6IP protein Acetylcysteine inhibits the reaction [hesperetin results in decreased expression of PDCD6IP protein] |
CTD |
PMID:37487865 |
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NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773
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G |
Por |
cytochrome p450 oxidoreductase |
multiple interactions |
EXP |
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein] |
CTD |
PMID:19497424 |
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NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases expression multiple interactions |
ISO |
hesperetin results in decreased expression of PPARG mRNA; hesperetin results in decreased expression of PPARG protein [hesperetin analog co-treated with PPARG protein] affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG protein] |
CTD |
PMID:25345581 PMID:28428136 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Pten |
phosphatase and tensin homolog |
multiple interactions |
EXP |
hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]] |
CTD |
PMID:27818223 |
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NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions affects activity |
ISO EXP |
hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein] hesperetin affects the activity of PTGS2 protein |
CTD |
PMID:15240993 PMID:16101151 PMID:35567572 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of RELA protein] |
CTD |
PMID:26546711 PMID:35567572 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Retn |
resistin |
decreases expression |
ISO |
hesperetin results in decreased expression of RETN mRNA |
CTD |
PMID:25345581 |
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NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
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G |
Shbg |
sex hormone binding globulin |
affects binding |
ISO |
hesperetin binds to SHBG protein |
CTD |
PMID:25349334 |
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NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
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G |
Sirt3 |
sirtuin 3 |
affects binding |
ISO |
hesperetin binds to SIRT3 protein |
CTD |
PMID:37487865 |
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NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
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G |
Sirt6 |
sirtuin 6 |
multiple interactions increases expression |
ISO |
[Cisplatin co-treated with hesperetin] results in increased expression of SIRT6 protein hesperetin results in increased expression of SIRT6 protein |
CTD |
PMID:31153982 |
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NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
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G |
Slc16a1 |
solute carrier family 16 member 1 |
multiple interactions |
EXP |
[hesperetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate |
CTD |
PMID:17108059 |
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NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
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G |
Socs3 |
suppressor of cytokine signaling 3 |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SOCS3 protein] |
CTD |
PMID:33522063 |
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NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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G |
Sod1 |
superoxide dismutase 1 |
increases expression |
ISO |
hesperetin results in increased expression of SOD1 protein |
CTD |
PMID:19023542 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
increases expression |
ISO |
hesperetin results in increased expression of SOD2 protein |
CTD |
PMID:19023542 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sox18 |
SRY-box transcription factor 18 |
multiple interactions |
ISO |
hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]; MIR410 mRNA affects the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]] |
CTD |
PMID:32762101 |
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NCBI chr 3:168,785,488...168,787,290
Ensembl chr 3:168,785,490...168,787,290
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT1 protein] |
CTD |
PMID:28428136 |
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NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP |
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:33522063 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
[hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of MYC protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]] |
CTD |
PMID:27818223 PMID:34922902 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions affects expression decreases expression |
ISO EXP |
[hesperetin analog co-treated with PPARG protein] affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; hesperetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]] hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of TNF protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF protein]; hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein] hesperetin affects the expression of TNF protein hesperetin results in decreased expression of TNF mRNA |
CTD |
PMID:11123379 PMID:16934226 PMID:24871567 PMID:25345581 PMID:26546711 PMID:28428136 PMID:32762101 PMID:33522063 PMID:34922902 PMID:35567572 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [hesperetin results in increased expression of TP53 protein]; hesperetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of TP53 protein] |
CTD |
PMID:15795422 PMID:37487865 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Uqcrfs1 |
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 |
affects binding |
ISO |
hesperetin binds to UQCRFS1 protein |
CTD |
PMID:37487865 |
|
NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479
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G |
Utrn |
utrophin |
increases expression |
ISO |
hesperetin results in increased expression of UTRN mRNA |
CTD |
PMID:22028826 |
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NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313
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G |
Ache |
acetylcholinesterase |
multiple interactions |
EXP |
[2,2-bis(4-glycidyloxyphenyl)propane co-treated with Hesperidin] inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein]; Hesperidin inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein] |
CTD |
PMID:32627286 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Afp |
alpha-fetoprotein |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] |
CTD |
PMID:28935427 PMID:30779474 |
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NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of AKT1 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in decreased activity of AKT1 protein] |
CTD |
PMID:30779474 PMID:35413380 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Akt2 |
AKT serine/threonine kinase 2 |
multiple interactions increases expression |
EXP |
Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of AKT2 mRNA] Hesperidin results in increased expression of AKT2 mRNA |
CTD |
PMID:36966900 |
|
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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G |
Alb |
albumin |
multiple interactions increases expression |
ISO |
[Hesperidin co-treated with Doxorubicin] results in increased expression of ALB protein Hesperidin results in increased expression of ALB protein |
CTD |
PMID:29481770 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions decreases expression |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of ATF6 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of ATF6 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of ATF6 mRNA] Hesperidin results in decreased expression of ATF6 mRNA |
CTD |
PMID:34748272 PMID:35413380 PMID:36966900 |
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NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
EXP ISO |
[Hesperidin co-treated with Chlorpyrifos] results in increased expression of BAX mRNA; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of BAX mRNA] Doxorubicin promotes the reaction [Hesperidin results in increased expression of BAX mRNA] |
CTD |
PMID:24954035 PMID:29481770 PMID:32050098 PMID:33908150 PMID:34748272 PMID:35413380 PMID:35921949 PMID:36966900 More...
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
EXP ISO |
[Hesperidin co-treated with Chlorpyrifos] results in decreased expression of BCL2 mRNA; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in decreased expression of BCL2 mRNA] Hesperidin results in decreased expression of BCL2 mRNA Doxorubicin promotes the reaction [Hesperidin results in decreased expression of BCL2 mRNA] |
CTD |
PMID:22093918 PMID:24954035 PMID:29481770 PMID:30623541 PMID:32050098 PMID:33908150 PMID:34748272 PMID:35413380 PMID:35921949 PMID:36966900 More...
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Becn1 |
beclin 1 |
multiple interactions decreases expression |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of BECN1 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of BECN1 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of BECN1 protein] Hesperidin results in decreased expression of BECN1 protein |
CTD |
PMID:33908150 PMID:34748272 PMID:35413380 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bmp2 |
bone morphogenetic protein 2 |
increases expression |
EXP |
Hesperidin results in increased expression of BMP2 mRNA |
CTD |
PMID:21820093 |
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NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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G |
Casp3 |
caspase 3 |
multiple interactions decreases expression increases activity increases expression |
EXP ISO |
[Hesperidin co-treated with Chlorpyrifos] results in increased expression of CASP3 mRNA; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of CASP3 mRNA]; Hesperidin promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein] Hesperidin results in decreased expression of CASP3 protein [Hesperidin co-treated with Doxorubicin] results in increased activity of CASP3 protein; Doxorubicin promotes the reaction [Hesperidin results in increased expression of CASP3 mRNA] Hesperidin results in increased activity of CASP3 protein |
CTD |
PMID:22093918 PMID:29481770 PMID:30066062 PMID:30623541 PMID:30779474 PMID:33908150 PMID:34748272 PMID:35413380 PMID:35921949 PMID:36966900 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 protein] |
CTD |
PMID:22093918 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions decreases activity increases activity |
EXP ISO |
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [abamectin results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Finasteride results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in decreased activity of CAT protein] Hesperidin results in decreased activity of CAT protein Hesperidin results in increased activity of CAT protein Hesperidin inhibits the reaction [Doxorubicin results in increased activity of CAT protein] |
CTD |
PMID:22093918 PMID:29481770 PMID:30066062 PMID:30098279 PMID:30623541 PMID:30779474 PMID:31095933 PMID:32050098 PMID:33003968 PMID:33908150 PMID:34748272 PMID:35413380 PMID:36966900 More...
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of CCL3 protein]; Hesperidin inhibits the reaction [Ethanol results in increased expression of CCL3 protein] |
CTD |
PMID:30368987 PMID:30811821 |
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NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression |
ISO |
BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CCND1 mRNA]; BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CCND1 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CCND1 mRNA]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CCND1 protein] Hesperidin results in decreased expression of CCND1 mRNA; Hesperidin results in decreased expression of CCND1 protein |
CTD |
PMID:34984768 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of CDK2 protein] |
CTD |
PMID:30779474 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
multiple interactions decreases expression |
ISO |
BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK4 mRNA]; BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK4 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK4 mRNA]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK4 protein] Hesperidin results in decreased expression of CDK4 mRNA; Hesperidin results in decreased expression of CDK4 protein |
CTD |
PMID:34984768 |
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NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdk6 |
cyclin-dependent kinase 6 |
decreases expression multiple interactions |
ISO |
Hesperidin results in decreased expression of CDK6 mRNA; Hesperidin results in decreased expression of CDK6 protein BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK6 mRNA]; BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK6 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK6 mRNA]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK6 protein] |
CTD |
PMID:34984768 |
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NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
ISO |
BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1A mRNA]; BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1A protein] Hesperidin results in increased expression of CDKN1A mRNA; Hesperidin results in increased expression of CDKN1A protein |
CTD |
PMID:34984768 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
multiple interactions increases expression |
ISO |
BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1B mRNA]; BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1B protein] Hesperidin results in increased expression of CDKN1B mRNA; Hesperidin results in increased expression of CDKN1B protein |
CTD |
PMID:34984768 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein] |
CTD |
PMID:17400256 |
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NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions increases expression |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of EIF2AK3 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of EIF2AK3 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of EIF2AK3 mRNA] Hesperidin results in increased expression of EIF2AK3 mRNA |
CTD |
PMID:34748272 PMID:35413380 PMID:36966900 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of ERN1 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of ERN1 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of ERN1 mRNA] |
CTD |
PMID:34748272 PMID:35413380 PMID:36966900 |
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NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Fabp9 |
fatty acid binding protein 9 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of FABP9 protein] |
CTD |
PMID:32050098 |
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NCBI chr 2:91,591,842...91,595,873
Ensembl chr 2:91,592,298...91,595,873
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G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein] |
CTD |
PMID:16427799 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
G6pc3 |
glucose 6 phosphatase catalytic subunit 3 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Streptozocin results in decreased activity of G6PC3 protein] |
CTD |
PMID:31345080 |
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NCBI chr10:87,146,987...87,151,223
Ensembl chr10:87,146,901...87,151,221
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
decreases activity multiple interactions |
ISO EXP |
Hesperidin results in decreased activity of G6PD protein Hesperidin inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein] |
CTD |
PMID:16427799 PMID:25130191 PMID:31345080 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gck |
glucokinase |
multiple interactions |
ISO |
Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA] |
CTD |
PMID:16427799 |
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NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
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G |
Gpt |
glutamic--pyruvic transaminase |
decreases activity multiple interactions |
ISO EXP |
Hesperidin results in decreased activity of GPT protein Hesperidin inhibits the reaction [Chlorpyrifos results in increased activity of GPT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased activity of GPT protein] [Doxorubicin co-treated with Hesperidin] results in decreased activity of GPT protein |
CTD |
PMID:29481770 PMID:30066062 PMID:30779474 PMID:33908150 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] |
CTD |
PMID:22093918 PMID:30098279 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 protein] |
CTD |
PMID:22093918 PMID:30098279 |
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NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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G |
Hdac1 |
histone deacetylase 1 |
multiple interactions |
ISO |
Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]] |
CTD |
PMID:34800614 |
|
NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
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|
G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
ISO |
Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein] |
CTD |
PMID:16427799 |
|
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of HMOX1 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of HMOX1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HMOX1 protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of HMOX1 mRNA] |
CTD |
PMID:28935427 PMID:32050098 PMID:34748272 PMID:35921949 PMID:36966900 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein] |
CTD |
PMID:32050098 |
|
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of HSPA5 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of HSPA5 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 mRNA] |
CTD |
PMID:34748272 PMID:35413380 PMID:36966900 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
Hesperidin inhibits the reaction [Glucose results in increased expression of ICAM1]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
CTD |
PMID:17400256 PMID:22074828 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein] Hesperidin inhibits the reaction [abamectin results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of IL1B protein] Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] |
CTD |
PMID:17400256 PMID:30066062 PMID:33908150 PMID:34748272 PMID:35413380 PMID:35921949 PMID:36966900 More...
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|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
Hesperidin promotes the reaction [Lipopolysaccharides results in increased expression of IL4 protein] |
CTD |
PMID:17400256 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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|
G |
Il6 |
interleukin 6 |
multiple interactions decreases expression |
ISO EXP |
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] Hesperidin results in decreased expression of IL6 protein [naringin co-treated with Hesperidin] results in decreased expression of IL6 protein; Hesperidin inhibits the reaction [abamectin results in increased expression of IL6 mRNA]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL6 mRNA]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] |
CTD |
PMID:17400256 PMID:21820093 PMID:30066062 PMID:30623541 PMID:34748272 PMID:35921949 More...
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|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Jak2 |
Janus kinase 2 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of JAK2 mRNA] |
CTD |
PMID:34748272 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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|
G |
Lep |
leptin |
decreases expression multiple interactions |
EXP |
Hesperidin results in decreased expression of LEP protein [naringin co-treated with Hesperidin] results in decreased expression of LEP protein |
CTD |
PMID:21820093 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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|
G |
Lepr |
leptin receptor |
multiple interactions |
ISO |
Hesperidin affects the reaction [LEPR protein affects the abundance of Glucose]; Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein]; Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]; Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein]; Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA]; Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] |
CTD |
PMID:16427799 |
|
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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G |
Map1lc3a |
microtubule-associated protein 1 light chain 3 alpha |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3A mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAP1LC3A mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of MAP1LC3A protein] |
CTD |
PMID:34748272 PMID:35413380 PMID:35921949 |
|
NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3B mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAP1LC3B mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of MAP1LC3B protein] |
CTD |
PMID:34748272 PMID:35413380 PMID:35921949 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Map2k5 |
mitogen activated protein kinase kinase 5 |
decreases phosphorylation |
ISO |
Hesperidin results in decreased phosphorylation of MAP2K5 protein |
CTD |
PMID:34984768 |
|
NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of MAPK14 mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of MAPK14 protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAPK14 mRNA] |
CTD |
PMID:33908150 PMID:34748272 PMID:35921949 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk7 |
mitogen-activated protein kinase 7 |
multiple interactions |
ISO |
BIX 02189 promotes the reaction [Hesperidin results in decreased phosphorylation of MAPK7 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased phosphorylation of MAPK7 protein]; Hesperidin results in decreased phosphorylation of and affects the localization of MAPK7 protein |
CTD |
PMID:34984768 |
|
NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:19110045 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:19110045 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mir126b |
microRNA 126b |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MIR126B mRNA] |
CTD |
PMID:32050098 |
|
NCBI chr 3:9,415,087...9,415,159
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|
G |
Mir181a2 |
microRNA 181a-2 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MIR181A2 mRNA] |
CTD |
PMID:32050098 |
|
NCBI chr 3:22,615,845...22,615,961
Ensembl chr 3:22,615,845...22,615,961
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MMP2 mRNA] |
CTD |
PMID:35921949 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases secretion |
ISO EXP |
Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of and results in increased activity of MMP9 protein]; Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of MMP9 mRNA]; Hesperidin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA] Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MMP9 mRNA] Hesperidin results in decreased secretion of MMP9 protein |
CTD |
PMID:19110045 PMID:20138977 PMID:35921949 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mpo |
myeloperoxidase |
multiple interactions decreases activity |
EXP |
Hesperidin inhibits the reaction [Acetic Acid results in increased activity of MPO protein] Hesperidin results in decreased activity of MPO protein |
CTD |
PMID:31095933 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Sodium Fluoride results in decreased expression of MTOR protein] |
CTD |
PMID:35413380 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases expression |
EXP |
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of NFE2L2 mRNA] Hesperidin results in increased expression of NFE2L2 mRNA |
CTD |
PMID:28935427 PMID:32050098 PMID:34748272 PMID:35921949 PMID:36966900 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions increases expression |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of NFKB1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NFKB1 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of NFKB1 mRNA] Hesperidin results in increased expression of NFKB1 mRNA |
CTD |
PMID:22093918 PMID:34748272 PMID:35921949 PMID:36966900 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP ISO |
Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of NOS2 protein] Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:12512693 PMID:22093918 PMID:33908150 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
EXP |
[Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 mRNA; [Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 protein; Hesperidin inhibits the reaction [Ethanol results in increased activity of PARP1 protein] |
CTD |
PMID:30368987 PMID:33908150 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of PCNA protein] |
CTD |
PMID:28935427 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein] |
CTD |
PMID:30779474 |
|
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
EXP ISO |
Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG protein]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein] Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein] |
CTD |
PMID:16427799 PMID:24954035 PMID:28935427 PMID:30623541 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Dextran Sulfate results in decreased expression of PPARGC1A protein]; Hesperidin inhibits the reaction [Ethanol results in decreased expression of PPARGC1A protein] |
CTD |
PMID:30368987 PMID:30811821 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO EXP |
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein] Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of PTGS2 mRNA] |
CTD |
PMID:16101151 PMID:19110045 PMID:30098279 PMID:33908150 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Isoproterenol results in increased expression of RELA protein] |
CTD |
PMID:30623541 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Sgpp2 |
sphingosine-1-phosphate phosphatase 2 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SGPP2 mRNA] |
CTD |
PMID:30811821 |
|
NCBI chr 9:79,762,658...79,884,665
Ensembl chr 9:79,763,284...79,880,457
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G |
Sirt1 |
sirtuin 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein] |
CTD |
PMID:32050098 |
|
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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G |
Slc1a2 |
solute carrier family 1 member 2 |
multiple interactions |
ISO |
Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein] |
CTD |
PMID:34800614 |
|
NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
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G |
Slc2a2 |
solute carrier family 2 member 2 |
multiple interactions |
ISO |
Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein] |
CTD |
PMID:16427799 |
|
NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions |
ISO |
Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein] |
CTD |
PMID:16427799 |
|
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Sod2 |
superoxide dismutase 2 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 protein] |
CTD |
PMID:32050098 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Sphk1 |
sphingosine kinase 1 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] |
CTD |
PMID:30811821 |
|
NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [abamectin results in increased expression of STAT3 mRNA] |
CTD |
PMID:34748272 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tfeb |
transcription factor EB |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Ethanol results in decreased expression of TFEB mRNA] |
CTD |
PMID:30368987 |
|
NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
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G |
Tnc |
tenascin C |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [Ethanol results in increased expression of TNC protein] |
CTD |
PMID:30368987 |
|
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases expression |
ISO EXP |
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] Hesperidin results in decreased expression of TNF mRNA Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of TNF protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of TNF mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of TNF mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of TNF protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of TNF protein] Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
CTD |
PMID:17400256 PMID:28935427 PMID:30066062 PMID:30623541 PMID:33908150 PMID:34748272 PMID:35413380 PMID:35921949 PMID:36966900 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf25 |
TNF receptor superfamily member 25 |
increases expression |
ISO |
Hesperidin results in increased expression of TNFRSF25 mRNA |
CTD |
PMID:24633329 |
|
NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
Hesperidin inhibits the reaction [sodium arsenite results in increased expression of TP53 protein] |
CTD |
PMID:30066062 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tradd |
TNFRSF1A-associated via death domain |
increases expression |
ISO |
Hesperidin results in increased expression of TRADD mRNA |
CTD |
PMID:24633329 |
|
NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions decreases expression |
ISO |
Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] Hesperidin results in decreased expression of VCAM1 |
CTD |
PMID:17400256 PMID:30991044 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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|
G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
EXP |
[Hesperidin co-treated with Chlorpyrifos] results in increased expression of VEGFA protein |
CTD |
PMID:33908150 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Yy1 |
YY1 transcription factor |
multiple interactions |
ISO |
Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of and affects the localization of YY1 protein] |
CTD |
PMID:34800614 |
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NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein] |
CTD |
PMID:29902531 |
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NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein] |
CTD |
PMID:29902531 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2L1 protein] |
CTD |
PMID:29902531 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein] |
CTD |
PMID:29902531 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein] |
CTD |
PMID:29902531 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein] |
CTD |
PMID:31850465 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
homoeriodictyol results in decreased activity of CYP1A1 protein |
CTD |
PMID:10781868 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
homoeriodictyol results in decreased activity of CYP1B1 protein |
CTD |
PMID:10781868 |
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NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
homoeriodictyol results in increased expression of GCLM mRNA |
CTD |
PMID:29902531 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Ghrl |
ghrelin and obestatin prepropeptide |
multiple interactions |
ISO |
[homoeriodictyol co-treated with Glucose] results in increased secretion of GHRL protein |
CTD |
PMID:28834253 |
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NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:31850465 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] |
CTD |
PMID:31850465 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:31850465 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
homoeriodictyol results in increased expression of and results in increased localization of NFE2L2 protein; homoeriodictyol results in increased stability of and results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein] |
CTD |
PMID:29902531 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:31850465 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] |
CTD |
PMID:31850465 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
ISO |
homoeriodictyol results in increased expression of NQO1 mRNA NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein] |
CTD |
PMID:29902531 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein] |
CTD |
PMID:29902531 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:31850465 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of RELA protein] |
CTD |
PMID:31850465 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:31850465 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
multiple interactions |
ISO |
[astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA |
CTD |
PMID:29471006 |
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NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:29471006 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein] |
CTD |
PMID:29471006 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] |
CTD |
PMID:29471006 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] |
CTD |
PMID:29471006 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein] |
CTD |
PMID:29471006 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein] |
CTD |
PMID:29471006 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA] |
CTD |
PMID:29471006 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions |
ISO |
astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA] |
CTD |
PMID:29471006 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein] |
CTD |
PMID:29471006 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein] |
CTD |
PMID:29471006 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:29471006 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:29471006 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein] astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein] |
CTD |
PMID:29471006 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:29471006 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] |
CTD |
PMID:29471006 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA] |
CTD |
PMID:29471006 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein] |
CTD |
PMID:29471006 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein] |
CTD |
PMID:29471006 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein] |
CTD |
PMID:29471006 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein] astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA] |
CTD |
PMID:29471006 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein] |
CTD |
PMID:29471006 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Bglap |
bone gamma-carboxyglutamate protein |
multiple interactions increases expression |
ISO |
neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of BGLAP mRNA] neoeriocitrin results in increased expression of BGLAP mRNA |
CTD |
PMID:21741227 |
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NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions increases expression |
ISO |
neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of COL1A1 mRNA] neoeriocitrin results in increased expression of COL1A1 mRNA |
CTD |
PMID:21741227 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Runx2 |
RUNX family transcription factor 2 |
increases expression |
ISO |
neoeriocitrin results in increased expression of RUNX2 mRNA |
CTD |
PMID:21741227 |
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NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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