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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:enamine
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Accession:CHEBI:47989 term browser browse the term
Definition:An amine RNR'R'' where R has a double bond adjacent to the amine nitrogen.
Synonyms:related_synonym: Formula=C2NR5;   SMILES=[*]\\C([*])=C(\\[*])N([*])[*];   enamines


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diaziquone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO diaziquone results in increased expression of CDKN1A mRNA
[NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; Acetylcysteine inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]; Dicumarol inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]
CTD PMID:8943236, PMID:9343371 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO diaziquone results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases activity
multiple interactions
increases metabolic processing
ISO [Dicumarol results in decreased activity of NQO1 protein] which results in decreased activity of diaziquone
[NQO1 protein results in increased metabolism of diaziquone] which results in increased abundance of Hydrogen Peroxide; [NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; NQO1 protein results in increased reduction of and results in increased activity of diaziquone
CTD PMID:2113030, PMID:9343371 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
neticonazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO neticonazole affects the localization of and results in increased activity of NR1I3 protein CTD PMID:30247703 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
nintedanib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tuba1a tubulin, alpha 1A decreases expression ISO nintedanib results in decreased expression of TUBA1A mRNA CTD PMID:27015953 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
JBrowse link
SL-327 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression
ISO SL 327 promotes the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein]
SL 327 results in increased expression of AHR protein
CTD PMID:15572374 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bdnf brain-derived neurotrophic factor increases response to substance
multiple interactions
ISO BDNF gene mutant form results in increased susceptibility to SL 327
SL 327 inhibits the reaction [Dronabinol results in increased expression of BDNF mRNA]
CTD PMID:12657697, PMID:16945347 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
decreases secretion
EXP SL 327 results in decreased expression of CCL2 mRNA
SL 327 results in decreased secretion of CCL2 protein
CTD PMID:20050970 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein] CTD PMID:16339038 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO SL 327 inhibits the reaction [Chenodeoxycholic Acid results in increased expression of EGR1 mRNA]; SL 327 inhibits the reaction [Chenodeoxycholic Acid results in increased expression of EGR1 protein]; SL 327 inhibits the reaction [Deoxycholic Acid results in increased expression of EGR1 mRNA]; SL 327 inhibits the reaction [Deoxycholic Acid results in increased expression of EGR1 protein]; SL 327 inhibits the reaction [Dronabinol results in increased expression of EGR1 mRNA]; SL 327 inhibits the reaction [Dronabinol results in increased expression of EGR1 protein] CTD PMID:11553284, PMID:12657697, PMID:19931294 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO SL 327 inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of ELK1 protein]; SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of ELK1 protein] CTD PMID:11553284, PMID:12871586 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [Cocaine results in increased activity of FOS protein]; SL 327 inhibits the reaction [Cocaine results in increased expression of FOS mRNA]; SL 327 inhibits the reaction [Cocaine results in increased expression of FOS protein]; SL 327 inhibits the reaction [Dronabinol results in increased expression of FOS protein]
SL 327 inhibits the reaction [Amphetamine results in increased expression of FOS mRNA]; SL 327 inhibits the reaction [Naloxone results in increased expression of FOS protein]
CTD PMID:11553284, PMID:12657697, PMID:15056714, PMID:15447667, PMID:16263220, PMID:17549049, PMID:18479823 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form] CTD PMID:15056714, PMID:16263220 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit multiple interactions ISO SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSL2 protein] CTD PMID:15056714 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]] CTD PMID:25550330 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]] CTD PMID:25550330 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein] CTD PMID:16473939 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP SL 327 results in decreased expression of IL1B CTD PMID:20050970 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO SL 327 inhibits the reaction [Cocaine results in increased expression of JUNB protein] CTD PMID:16263220 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Kl Klotho multiple interactions ISO SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]] CTD PMID:25550330 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
SL 327 inhibits the reaction [[benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOSL2 protein]; SL 327 inhibits the reaction [Chenodeoxycholic Acid results in increased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SL 327 inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; SL 327 inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK1 protein]
SL 327 results in decreased phosphorylation of MAPK1 protein
SL 327 inhibits the reaction [HU 211 results in increased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK1 protein]; SL 327 results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
CTD PMID:12657697, PMID:12871586, PMID:15056714, PMID:16473939, PMID:17596448, PMID:17623046, PMID:19402951, PMID:19931294, PMID:20050970, PMID:20081235, PMID:25550330 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO
EXP
SL 327 inhibits the reaction [[benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOS protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSB protein]; SL 327 inhibits the reaction [[Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein] which results in increased expression of FOSL2 protein]; SL 327 inhibits the reaction [Chenodeoxycholic Acid results in increased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SL 327 inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; SL 327 inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]; SL 327 inhibits the reaction [Pilocarpine results in increased phosphorylation of MAPK3 protein]
SL 327 inhibits the reaction [HU 211 results in increased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]; SL 327 results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
SL 327 results in decreased phosphorylation of MAPK3 protein
CTD PMID:12657697, PMID:12871586, PMID:15056714, PMID:16473939, PMID:17596448, PMID:17623046, PMID:19402951, PMID:19931294, PMID:20050970, PMID:20081235, PMID:25550330 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]] CTD PMID:25550330 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Pdyn prodynorphin multiple interactions EXP SL 327 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA] CTD PMID:16459022 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Penk proenkephalin multiple interactions EXP SL 327 inhibits the reaction [Dextroamphetamine results in increased expression of PENK mRNA] CTD PMID:16459022 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 multiple interactions EXP SL 327 inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein] CTD PMID:17623046 NCBI chr 1:103,197,918...103,258,309
Ensembl chr 1:103,197,915...103,256,823
JBrowse link
G Rnd3 Rho family GTPase 3 multiple interactions ISO SL 327 inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RND3 mRNA] CTD PMID:17196187 NCBI chr 3:36,643,374...36,660,727
Ensembl chr 3:36,642,587...36,660,758
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 multiple interactions ISO SL 327 inhibits the reaction [[benserazide, levodopa drug combination co-treated with Oxidopamine] results in increased phosphorylation of RPS6KA5 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RPS6KA5 protein] CTD PMID:16339038, PMID:17596448 NCBI chr 6:124,557,892...124,735,787
Ensembl chr 6:124,557,913...124,735,778
JBrowse link
U0126 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP U0126 inhibits the reaction [17alpha-ethynylestradiol increases phosphorylation of Prkaa1 in primary hepatocytes] RGD PMID:27090119 RGD:15090804 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        refrigerant 17418
          ammonia 16940
            organic amino compound 16939
              amine 7602
                enamine 29
                  (-)-echitovenine 0
                  (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioic acid 0
                  (Z)-2-aminobutenoic acid 0
                  (Z)-3-amino-2-methylacrylic acid + 0
                  (Z)-3-aminoperacrylic acid 0
                  (Z)-dehydrotyrosine 0
                  1,4-diamino-2,3-dicyano-1,4-bis(phenylthio)butadiene 0
                  2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 0
                  2-amino-4-(3-cyclohexen-1-yl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrochromene-3-carbonitrile 0
                  2-aminoacrylic acid + 0
                  3-methyl-4-[(4'-methyl[2,2'-bipyridin]-4-yl)imino]but-2-en-2-amine 0
                  4-[(5-oxo-2-phenyl-1,3-oxazol-4-ylidene)methylamino]but-2-enoic acid 0
                  4-[1-(benzylamino)ethylidene]-2-(2,4-dibromophenyl)-5-methyl-2,4-dihydropyrazol-3-one 0
                  SL-327 23
                  U0126 + 1
                  bacillaene 0
                  coelimycin P1 0
                  dehydrosecodine 0
                  diaziquone 3
                  flupyradifurone 0
                  hesperadin 0
                  indigoidine 0
                  neticonazole 1
                  nintedanib 1
                  secodine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        amine 7602
                                          enamine 29
                                            (-)-echitovenine 0
                                            (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioic acid 0
                                            (Z)-2-aminobutenoic acid 0
                                            (Z)-3-amino-2-methylacrylic acid + 0
                                            (Z)-3-aminoperacrylic acid 0
                                            (Z)-dehydrotyrosine 0
                                            1,4-diamino-2,3-dicyano-1,4-bis(phenylthio)butadiene 0
                                            2,5-bis(2-hydroxyethylamino)-3,6-diaziridinylbenzoquinone 0
                                            2-amino-4-(3-cyclohexen-1-yl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrochromene-3-carbonitrile 0
                                            2-aminoacrylic acid + 0
                                            3-methyl-4-[(4'-methyl[2,2'-bipyridin]-4-yl)imino]but-2-en-2-amine 0
                                            4-[(5-oxo-2-phenyl-1,3-oxazol-4-ylidene)methylamino]but-2-enoic acid 0
                                            4-[1-(benzylamino)ethylidene]-2-(2,4-dibromophenyl)-5-methyl-2,4-dihydropyrazol-3-one 0
                                            SL-327 23
                                            U0126 + 1
                                            bacillaene 0
                                            coelimycin P1 0
                                            dehydrosecodine 0
                                            diaziquone 3
                                            flupyradifurone 0
                                            hesperadin 0
                                            indigoidine 0
                                            neticonazole 1
                                            nintedanib 1
                                            secodine 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.