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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:imidazoquinazoline
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Accession:CHEBI:47975 term browser browse the term
Synonyms:related_synonym: imidazoquinazolines



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anagrelide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fli1 Fli-1 proto-oncogene, ETS transcription factor multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of FLI1 mRNA] CTD PMID:20586925 NCBI chr 8:30,831,422...30,950,468
Ensembl chr 8:30,832,753...30,950,433
JBrowse link
G Gata1 GATA binding protein 1 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 protein] CTD PMID:20586925 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530
JBrowse link
G Itga2b integrin subunit alpha 2b multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of ITGA2B mRNA] CTD PMID:20586925 NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168
JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of MPL mRNA] CTD PMID:20586925 NCBI chr 5:131,973,897...131,987,472
Ensembl chr 5:131,973,895...131,986,797
JBrowse link
G Nfe2 nuclear factor, erythroid 2 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of NF-E2 mRNA] CTD PMID:20586925 NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108
JBrowse link
G Pdgfb platelet derived growth factor subunit B increases expression ISO anagrelide results in increased expression of PDGFB mRNA CTD PMID:15682418 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO anagrelide results in decreased expression of TGFB1 mRNA CTD PMID:15682418 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thpo thrombopoietin multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of FLI1 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of GATA1 protein]; anagrelide inhibits the reaction [THPO protein results in increased expression of ITGA2B mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of MPL mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of NF-E2 mRNA]; anagrelide inhibits the reaction [THPO protein results in increased expression of ZFPM1 mRNA] CTD PMID:20586925 Ensembl chr11:80,182,820...80,188,167 JBrowse link
G Zfpm1 zinc finger protein, multitype 1 multiple interactions ISO anagrelide inhibits the reaction [THPO protein results in increased expression of ZFPM1 mRNA] CTD PMID:20586925 NCBI chr19:50,334,352...50,391,029
Ensembl chr19:50,334,682...50,390,591
JBrowse link
copanlisib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO copanlisib results in decreased phosphorylation of AKT1 protein CTD PMID:31445927 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO copanlisib affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO copanlisib results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      atom 20054
        nonmetal atom 19945
          nitrogen atom 18932
            nitrogen molecular entity 18932
              organonitrogen compound 18703
                organonitrogen heterocyclic compound 17731
                  imidazoquinazoline 12
                    3-(2-deoxy-5-O-phosphono-beta-D-ribofuranosyl)-3H-imidazo[4,5-g]quinazolin-8-amine 0
                    6-amino-3-(2-deoxy-5-O-phosphono-beta-D-ribofuranosyl)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one 0
                    anagrelide + 9
                    copanlisib + 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                organic heterocyclic compound 18798
                                  organic heteropolycyclic compound 18272
                                    organic heterotricyclic compound 15596
                                      imidazoquinazoline 12
                                        3-(2-deoxy-5-O-phosphono-beta-D-ribofuranosyl)-3H-imidazo[4,5-g]quinazolin-8-amine 0
                                        6-amino-3-(2-deoxy-5-O-phosphono-beta-D-ribofuranosyl)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one 0
                                        anagrelide + 9
                                        copanlisib + 3
paths to the root